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Abstract Accumulation of β‐amyloid peptide (Aβ) induces neurotoxicity, which is the primary risk factor in the pathogenesis of Alzheimer's disease (AD). The cleavage of amyloid precursor protein (APP) by the β‐ (BACE) and γ‐ (PS1, PS2) secretases is a critical step in the amyloidogenic pathway. The induction of neuronal apoptosis by Aβ involves increased expression of B‐cell lymphoma protein 2 (Bcl‐2)‐associated X (Bax) and decreased Bcl‐2 expression. The seed of Carthamus tinctorius L. (CTS) and the aerial part of Taraxacum coreanum (TC) are traditional herbs used to treat several neurodegenerative diseases. In this study, the neuroprotective effects of co‐treatment with CTS and TC on Aβ‐induced neurotoxicity in SH‐SY5Y neuroblastoma cells and the underlying mechanisms were investigated. CTS, TC, and the co‐treatment (CTS + TC) were added to Aβ25–35‐treated SH‐SY5Y cells. CTS + TC synergistically increased cell viability and inhibited reactive oxygen species production. CTS + TC resulted in significant downregulation of BACE, PS1, PS2, and APP, as well as the 99‐aa C‐terminal domain of APP, compared with either CTS or TC alone. Compared with the single herbs, co‐treatment with CTS and TC markedly decreased the expression of Bax and increased the expression of Bcl‐2, consistent with its anti‐apoptotic effects. These findings suggest that co‐treatment with CTS and TC may be useful for AD prevention.

This study examines how different primary school campus layouts impact the wind environment and classroom ventilation in Xi’an, using simulations for winter and summer conditions. It evaluates four typical floorplans to find the best for outdoor wind quality and classroom ventilation. During winter, the outdoor wind speed at a height of 1.5 m remains below 5 m/s, adhering to the Green Building Evaluation Standard (GB/T50378-2019). Notably, Scenario 1 achieves higher wind speeds due to the canyon effect between buildings, facilitating effective air renewal. The wind speed amplification factors in all scenarios are within the permissible limit of 2, while Scenario 1 demonstrates superior outdoor wind performance. Wind pressure differences on building surfaces remain within the 5 Pa limit, with Scenario 3 exhibiting the lowest difference of 0.74 Pa, contributing to energy-efficient heating. In summer, Scenario 1 uniquely avoids vortex areas and windless zones, ensuring efficient airflow across the campus. Its open floor planning prevents the formation of stagnant air zones, in contrast to Scenarios 2, 3, and 4, which create enclosed or semi-enclosed spaces promoting vortex formation and windless areas. These findings underscore the benefits of Scenario 1’s design in optimizing both winter and summer wind environments for energy efficiency and occupant comfort. This study recommends including adequately sized spaces in zigzag, branched, or enclosed floor plans to provide airflow and prevent high wind speeds. These results are crucial for shaping upcoming architectural plans to improve the environmental quality of school grounds, leading to improved health and comfort for students and teachers.

To achieve high maize (Zea mays L.) yields and quality grain, it is necessary to develop stress-resistant cultivars and related cultivation practices, aiming to maximize efficiency. Thus, our objectives were (i) to investigate the impact of tillage practices and maize hybrids (which have improved over time) on yield and its components, and (ii) to characterize the response pattern of maize hybrid grain nutrient quality components to subsoiling. To achieve this, we conducted field trials with five maize hybrids from different eras under two tillage practices: rotary tillage and subsoiling. We compared grain yield, nutritional quality, and other indicators across different tillage conditions from the 1970s to the 2010s. The main results of this study are as follows: under rotary tillage conditions, the 2010s hybrid (DH618) significantly increased yields (9.37–55.89%) compared to hybrids from the 1970s–2000s. After subsoiling, the physiologically mature grains of all hybrids exhibited minimal changes in crude protein and fat content, while there was a significant reduction in the total soluble sugar content of the grains. After subsoiling, there was a substantial 8.14 to 12.79 percent increase in total starch accumulation in the grain for all hybrids during the period of 47–75 days post-anthesis. Furthermore, during the period of 47–75 days after anthesis, the consumption of grain crude protein significantly contributed to the accumulation of total starch in the grains. Ultimately, subsoiling significantly increased the yield of each hybrid and enhanced the total grain starch content at physiological maturity of all hybrids, with the 2010s hybrid (DH618) performing exceptionally well.

Abstract Inorganic metal halide perovskite CsPbX3 (X = I, Br, and Cl) nanocrystals (NCs) are rapidly developed due to their excellent photophysical properties and potential applications in lighting, lasers, and scintillators. However, the materials for growing perovskite NCs are insoluble or hydrolyzed in most green solvents, limiting their further development. Based on rational chemical analysis, an alkali‐metal–assisted green‐solvent synthesis method for in situ growth of CsPbBr3 NCs within SAPO‐34 zeolite with bright luminescence is developed. Water is the only solvent used in the whole process. Surprisingly, by the synergistic effect of the channel structure of SAPO‐34 and alkali‐metal ions crystallization regulation, the CsPbBr3 NCs embedded in SAPO‐34 assisted by Na+ emit bright blue light under ultraviolet illumination, with a 30 nm blue shift comparing to the CsPbBr3 NCs assisted by K+. Moreover, CsPbBr3 NCs can also be grown in mesoporous SiO2 SBA‐15 and zeolites including ZSM‐5, AlPO‐5, and SOD, indicating that the method is universal for in situ growth of luminescent perovskite NCs in porous materials. This alkali‐metal–assisted green‐solvent synthesis provides a new strategy for developing high‐quantum–yield, tunable‐emission, and stable perovskite luminescent materials.

Dementia, with homocysteine (Hcy) as an important risk factor, is a severe public health problem in the aging society. Betaine serves as a methyl donor and plays an important role in reducing Hcy. However, the effects and mechanisms of betaine on Hcy-induced cognitive impairment remain unclear. Firstly, SD rats were injected with Hcy (400 μg/kg) through vena caudalis, and betaine (2.5 % w/v) was supplemented via drinking water for 14 days. Betaine supplementation could attenuate Hcy-induced cognitive impairment in the Y maze and novel object recognition tests by repairing brain injury. Meanwhile, microglial activation was observed to be inhibited by betaine supplementation using immunofluorescence and sholl analysis. Secondly, HMC3 cells were treated with betaine, which was found to decrease the ROS level, ameliorate cell membrane rupture, reduce the release of LDH, IL-18 and IL-1β, and attenuate the damage of microglia to neurons. Mechanistically, betaine alleviates cognitive impairment by inhibiting microglial pyroptosis via reducing the expressions of NLRP3, ASC, pro-caspase-1, cleaved-caspase-1, GSDMD, GSDMD-N, IL-18 and IL-1β. Betaine treatment can increase SAM/SAH ratio, confirming its enhancement on methylation capacity. Furthermore, betaine treatment was found to enhance N6-methyladenosine (m6A) modification of NLRP3 mRNA, and reduced the NLRP3 mRNA stability through increasing the expression of the m6A reader YTH N6-methyladenosine RNA binding protein 2 (YTHDF2). Finally, silencing YTHDF2 could reverse the inhibitory effect of betaine on pyroptosis. Our data demonstrated that betaine attenuated Hcy-induced cognitive impairment by suppressing microglia pyroptosis via inhibiting the NLRP3/caspase-1/GSDMD pathway in an m6A-YTHDF2-dependent manner.