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6. Mitral annulus disjunction in consecutive patients undergoing cardiovascular magnetic resonance: Where is the boundary between normality and disease?

Author

Figliozzi, Stefano, Stankowski, Kamil, Tondi, Lara, Catapano, Federica, Gitto, Mauro, Lisi, Costanza, Bombace, Sara, Olivieri, Marzia, Cannata, Francesco, Fazzari, Fabio, Bragato, Renato Maria, Georgiopoulos, Georgios, Masci, Pier-Giorgio, Monti, Lorenzo, Condorelli, Gianluigi, and Francone, Marco

Published
2024
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8. Cardiac magnetic resonance predictors of left ventricular remodelling following acute ST elevation myocardial infarction: The VavirimS study

Author

Pica, Silvia, Crimi, Gabriele, Castelvecchio, Serenella, Pazzanese, Vittorio, Palmisano, Anna, Lombardi, Massimo, Tondi, Lara, Esposito, Antonio, Ameri, Pietro, Canale, Claudia, Cappelletti, Alberto, Alberti, Luca P., Tavano, Davide, Camporotondo, Rita, Costantino, Ilaria, Campodonico, Jenness, Pontone, Gianluca, Villani, Alessandra, Gallone, Gianluca Pio, Montone, Rocco A., Niccoli, Giampaolo, Gargiulo, Paola, Punzo, Bruna, Vicenzi, Marco, Carugo, Stefano, Menicanti, Lorenzo, Ambrosio, Giuseppe, and Camici, Paolo G.

Published
2023
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11. When Paying Attention Pays Back: Missense Mutation c.1006G>A p. (Val336Ile) in PRKAG2 Gene Causing Left Ventricular Hypertrophy and Conduction Abnormalities in a Caucasian Patient: Case Report and Literature Review.

Author

Micaglio, Emanuele, Tondi, Lara, Benedetti, Sara, Schiavo, Maria Alessandra, Camporeale, Antonia, Disabato, Giandomenico, Attanasio, Andrea, Guida, Gianluigi, Carrafiello, Gianpaolo, Piepoli, Massimo, Spagnolo, Pietro, Pappone, Carlo, and Lombardi, Massimo

Subjects
*CARDIAC magnetic resonance imaging, *LEFT ventricular hypertrophy, *HYPERTROPHIC cardiomyopathy, *LITERATURE reviews, *GENETIC disorders
Abstract

PRKAG2 cardiomyopathy is a rare genetic disorder that manifests early in life with an autosomal dominant inheritance pattern. It harbors left ventricular hypertrophy (LVH), ventricular pre-excitation and progressively worsening conduction system defects. Its estimated prevalence among patients with LVH ranges from 0.23 to about 1%, but it is likely an underdiagnosed condition. We report the association of the PRKAG2 missense variant c.1006G>A p. (Val336Ile) with LVH, conduction abnormalities (short PR interval and incomplete right bundle branch bock) and early-onset arterial hypertension (AH) in a 44-year-old Caucasian patient. While cardiac magnetic resonance (CMR) showed a mild hypertrophic phenotype with maximal wall thickness of 17 mm in absence of tissue alterations, the electric phenotype was relevant including brady–tachy syndrome and recurrent syncope. The same variant has been detected in the patient's sister and daughter, with LVH + early-onset AH and electrocardiographic (ECG) alterations + lipothymic episodes, respectively. Paying close attention to the coexistence of LVH and ECG alterations in the proband has been helpful in directing genetic tests to exclude primary cardiomyopathy. Hence, identifying the genetic basis in the patient allowed for familial screening as well as a proper follow-up and therapeutic management of the affected members. A review of the PRKAG2 cardiomyopathy literature is provided alongside the case report. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Corrigendum to “Cardiac magnetic resonance predictors of left ventricular remodelling following acute ST elevation myocardial infarction: The VavirimS study, Pica, Silvia et al.” [International Journal of Cardiology, Volume 370, 8–17]

Author

Pica, Silvia, primary, Crimi, Gabriele, additional, Castelvecchio, Serenella, additional, Pazzanese, Vittorio, additional, Palmisano, Anna, additional, Lombardi, Massimo, additional, Tondi, Lara, additional, Esposito, Antonio, additional, Ameri, Pietro, additional, Canale, Claudia, additional, Cappelletti, Alberto, additional, Alberti, Luca P., additional, Tavano, Davide, additional, Camporotondo, Rita, additional, Costantino, Ilaria, additional, Campodonico, Jenness, additional, Pontone, Gianluca, additional, Villani, Alessandra, additional, Gallone, Gianluca Pio, additional, Montone, Rocco A., additional, Niccoli, Giampaolo, additional, Gargiulo, Paola, additional, Punzo, Bruna, additional, Vicenzi, Marco, additional, Carugo, Stefano, additional, Menicanti, Lorenzo, additional, Ambrosio, Giuseppe, additional, and Camici, Paolo G., additional

Published
2024
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14. Prevalence and Clinical Significance of Mitral Annulus Disjunction in a Large Cohort of Consecutive Patients Undergoing Cardiovascular Magnetic Resonance

Author

Figliozzi, Stefano, primary, Stankowski, Kamil, additional, Lisi, Costanza, additional, Gitto, Mauro, additional, Olivieri, Marzia, additional, Locatelli, Elena, additional, Catapano, Federica, additional, Tondi, Lara, additional, Cannata, Francesco, additional, Fazzari, Fabio, additional, Bragato, Renato M, additional, Georgiopoulos, Georgios, additional, Masci, Pier Giorgio, additional, Monti, Lorenzo, additional, Condorelli, Gianluigi, additional, and Francone, Marco, additional

Published
2024
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15. Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine-learning Analysis Using a Multi-center Registry

Author

Figliozzi, Stefano, primary, Akyea, Ralph Kwame, additional, Lopes, Pedro M, additional, Moura-Ferreira, Sara, additional, Tondi, Lara, additional, Mushtaq, Saima, additional, Censi, Stefano, additional, Pavon, Anna Giulia, additional, Bassi, Ilaria, additional, Galian, Laura, additional, Teske, Arco J, additional, Filomena, Domenico, additional, Torlasco, Camilla, additional, Monney, Pierre, additional, Maestrini, Viviana, additional, Pedrotti, Patrizia, additional, Vandenberk, Bert, additional, Squeri, Angelo, additional, Lombardi, Massimo, additional, Schwitter, Juerg, additional, Aquaro, Giovanni Donato, additional, Chiribiri, Amedeo, additional, Palomares, José F Rodríguez, additional, Monti, Lorenzo, additional, Yilmaz, Ali, additional, Andreini, Daniele, additional, Florian, Anca, additional, Francone, Marco, additional, Pontone, Gianluca, additional, Abecassis, Joao, additional, Leiner, Tim, additional, Badano, Luigi P, additional, Bogaert, Jan, additional, Georgiopoulos, Georgios, additional, and Masci, Pier Giorgio, additional

Published
2024
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16. Left Ventricle Diastolic Vortex Ring Characterization in Ischemic Cardiomyopathy: Insight into Atrio-ventricular Interplay

Author

Riva, Alessandra, primary, Saitta, Simone, additional, Sturla, Francesco, additional, Disabato, Giandomenico, additional, Tondi, Lara, additional, Camporeale, Antonia, additional, Giese, Daniel, additional, Castelvecchio, Serenella, additional, Menicanti, Lorenzo, additional, Redaelli, Alberto, additional, Lombardi, Massimo, additional, and Votta, Emiliano, additional

Published
2024
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20. Kiosk 9R-TA-07 - Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine-learning Analysis Using a Multi-center Registry

Author

Figliozzi, Stefano, Akyea, Ralph Kwame, Lopes, Pedro M, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Galian, Laura, Teske, Arco J, Filomena, Domenico, Torlasco, Camilla, Monney, Pierre, Maestrini, Viviana, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Palomares, José F Rodríguez, Monti, Lorenzo, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Francone, Marco, Pontone, Gianluca, Abecassis, Joao, Leiner, Tim, Badano, Luigi P, Bogaert, Jan, Georgiopoulos, Georgios, and Masci, Pier Giorgio

Published
2024
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21. Kiosk 6R-TA-10 - Prevalence and Clinical Significance of Mitral Annulus Disjunction in a Large Cohort of Consecutive Patients Undergoing Cardiovascular Magnetic Resonance

Author

Figliozzi, Stefano, Stankowski, Kamil, Lisi, Costanza, Gitto, Mauro, Olivieri, Marzia, Locatelli, Elena, Catapano, Federica, Tondi, Lara, Cannata, Francesco, Fazzari, Fabio, Bragato, Renato M, Georgiopoulos, Georgios, Masci, Pier Giorgio, Monti, Lorenzo, Condorelli, Gianluigi, and Francone, Marco

Published
2024
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22. Kiosk 2R-FC-02 - Unveiling the Distinctive Phenotypes of Arrhythmic Mitral Valve Prolapse by High-density Myocardial Strain Imaging and Late-gadolinium-enhancement Microstructure Analysis

Author

Maio, Silvana Di, Zaidi, Hassan, Vandenberk, Bert, Censi, Stefano, Figliozzi, Stefano, Tondi, Lara, Lombardi, Massimo, Aquaro, Giovanni Donato, Andreini, Daniele, Bauer, Klemens B, Di Maio, Silvana, Squeri, Angelo, Torlasco, Camilla, Galian, Laura, Mushtaq, Saima, Rodríguez Palomares, José F, Marchenko, Oksana, Pontone, Gianluca, Monti, Lorenzo, Giulia Pavon, Anna, Teske, Arco J, Florian, Anca, Agricola, Eustachio, Francone, Marco, Badano, Luigi P, Yilmaz, Ali, Schwitter, Juerg, Georgiopoulos, Georgios, Lamata, Pablo, Grapsa, Julia, Leiner, Tim, Bogaert, Jan, Bishop, Martin, and Giorgio Masci, Pier

Published
2024
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25. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse

Author

Figliozzi, S, Georgiopoulos, G, Lopes, P, Bauer, K, Moura-Ferreira, S, Tondi, L, Mushtaq, S, Censi, S, Pavon, A, Bassi, I, Servato, M, Teske, A, Biondi, F, Filomena, D, Pica, S, Torlasco, C, Muraru, D, Monney, P, Quattrocchi, G, Maestrini, V, Agati, L, Monti, L, Pedrotti, P, Vandenberk, B, Squeri, A, Lombardi, M, Ferreira, A, Schwitter, J, Aquaro, G, Chiribiri, A, Rodríguez Palomares, J, Yilmaz, A, Andreini, D, Florian, A, Leiner, T, Abecasis, J, Badano, L, Bogaert, J, Masci, P, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi, Bogaert, Jan, Masci, Pier-Giorgio, Figliozzi, S, Georgiopoulos, G, Lopes, P, Bauer, K, Moura-Ferreira, S, Tondi, L, Mushtaq, S, Censi, S, Pavon, A, Bassi, I, Servato, M, Teske, A, Biondi, F, Filomena, D, Pica, S, Torlasco, C, Muraru, D, Monney, P, Quattrocchi, G, Maestrini, V, Agati, L, Monti, L, Pedrotti, P, Vandenberk, B, Squeri, A, Lombardi, M, Ferreira, A, Schwitter, J, Aquaro, G, Chiribiri, A, Rodríguez Palomares, J, Yilmaz, A, Andreini, D, Florian, A, Leiner, T, Abecasis, J, Badano, L, Bogaert, J, Masci, P, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi, Bogaert, Jan, and Masci, Pier-Giorgio

Abstract

Background: Patients with mitral valve prolapse (MVP) may develop adverse outcomes even in the absence of mitral regurgitation or left ventricular (LV) dysfunction. Purpose: To investigate the prognostic value of mitral annulus disjunction (MAD) and myocardial fibrosis at late gadolinium enhancement (LGE) cardiac MRI in patients with MVP without moderate-to-severe mitral regurgitation or LV dysfunction. Materials and Methods: In this longitudinal retrospective study, 118 144 cardiac MRI studies were evaluated between October 2007 and June 2020 at 15 European tertiary medical centers. Follow-up was from the date of cardiac MRI examination to June 2020; the minimum and maximum follow-up intervals were 6 months and 156 months, respectively. Patients were excluded if at least one of the following conditions was present: cardiomyopathy, LV ejection fraction less than 40%, ischemic heart disease, congenital heart disease, inflammatory heart disease, moderate or worse mitral regurgitation, participation in competitive sport, or electrocardiogram suggestive of channelopathies. In the remainder, cardiac MRI studies were reanalyzed, and patients were included if they were aged 18 years or older, MVP was diagnosed at cardiac MRI, and clinical information and electrocardiogram monitoring were available within 3 months from cardiac MRI examination. The end point was a composite of adverse outcomes: sustained ventricular tachycardia (VT), sudden cardiac death (SCD), or unexplained syncope. Multivariable Cox regression analysis was performed. Results: A total of 474 patients (mean age, 47 years ± 16 [SD]; 244 women) were included. Over a median follow-up of 3.3 years, 18 patients (4%) reached the study end point. LGE presence (hazard ratio, 4.2 [95% CI: 1.5, 11.9]; P = .006) and extent (hazard ratio, 1.2 per 1% increase [95% CI: 1.1, 1.4]; P = .006), but not MAD presence (P = .89), were associated with clinical outcome. LGE presence had incremental prognostic value over MVP severi

Published
2023

26. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse

Author

Team Medisch, Circulatory Health, MS Radiologie, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi Paolo, Bogaert, Jan, Masci, Pier-Giorgio, Team Medisch, Circulatory Health, MS Radiologie, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi Paolo, Bogaert, Jan, and Masci, Pier-Giorgio

Published
2023

28. Effect of Migalastat on cArdiac InvOlvement in FabRry DiseAse: MAIORA study.

Author

Camporeale, Antonia, Bandera, Francesco, Pieroni, Maurizio, Pieruzzi, Federico, Spada, Marco, Bersano, Anna, Econimo, Laura, Lanzillo, Chiara, Rubino, Marta, Mignani, Renzo, Motta, Irene, Olivotto, Iacopo, Tanini, Ilaria, Valaperta, Rea, Chow, Kelvin, Baroni, Irene, Boveri, Sara, Graziani, Francesca, Pica, Silvia, and Tondi, Lara

Abstract

Background A small but significant reduction in left ventricular (LV) mass after 18 months of migalastat treatment has been reported in Fabry disease (FD). This study aimed to assess the effect of migalastat on FD cardiac involvement, combining LV morphology and tissue characterisation by cardiac magnetic resonance (CMR) with cardiopulmonary exercise testing (CPET). Methods Sixteen treatment-naïve patients with FD (4 women, 46.4±16.2 years) with cardiac involvement (reduced T1 values on CMR and/or LV hypertrophy) underwent ECG, echocardiogram, troponin T and NTproBNP (N-Terminal prohormone of Brain Natriuretic Peptide) assay, CMR with T1 mapping, and CPET before and after 18 months of migalastat. Results No change in LV mass was detected at 18 months compared to baseline (95.2 g/m² (66.0–184.0) vs 99.0 g/m² (69.0–121.0), p=0.55). Overall, there was an increase in septal T1 of borderline significance (870.0 ms (848–882) vs 860.0 ms (833.0–875.0), p=0.056). Functional capacity showed an increase in oxygen consumption (VO2 ) at anaerobic threshold (15.50 mL/kg/ min (13.70–21.50) vs 14.50 mL/kg/min (11.70–18.95), p=0.02), and a trend towards an increase in percent predicted peak VO2 (72.0 (63.0–80.0) vs 69.0 (53.0– 77.0), p=0.056) was observed. The subset of patients who showed an increase in T1 value and a reduction in LV mass (n=7, 1 female, age 40.5 (28.6–76.0)) was younger and at an earlier disease stage compared to the others, and also exhibited greater improvement in exercise tolerance. Conclusion In treatment-naïve FD patients with cardiac involvement, 18-month treatment with migalastat stabilised LV mass and was associated with a trend towards an improvement in exercise tolerance. A tendency to T1 increase was detected by CMR. The subset of patients who had significant benefits from the treatment showed an earlier cardiac disease compared to the others. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse

Author

Figliozzi, Stefano, primary, Georgiopoulos, Georgios, additional, Lopes, Pedro M., additional, Bauer, Klemens B., additional, Moura-Ferreira, Sara, additional, Tondi, Lara, additional, Mushtaq, Saima, additional, Censi, Stefano, additional, Pavon, Anna Giulia, additional, Bassi, Ilaria, additional, Servato, Maria Luz, additional, Teske, Arco J., additional, Biondi, Federico, additional, Filomena, Domenico, additional, Pica, Silvia, additional, Torlasco, Camilla, additional, Muraru, Denisa, additional, Monney, Pierre, additional, Quattrocchi, Giuseppina, additional, Maestrini, Viviana, additional, Agati, Luciano, additional, Monti, Lorenzo, additional, Pedrotti, Patrizia, additional, Vandenberk, Bert, additional, Squeri, Angelo, additional, Lombardi, Massimo, additional, Ferreira, António M., additional, Schwitter, Juerg, additional, Aquaro, Giovanni Donato, additional, Chiribiri, Amedeo, additional, Rodríguez Palomares, José F., additional, Yilmaz, Ali, additional, Andreini, Daniele, additional, Florian, Anca, additional, Leiner, Tim, additional, Abecasis, João, additional, Badano, Luigi Paolo, additional, Bogaert, Jan, additional, and Masci, Pier-Giorgio, additional

Published
2023
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34. Comparison of Four‐Dimensional Magnetic Resonance Imaging Analysis of Left Ventricular Fluid Dynamics and Energetics in Ischemic and Restrictive Cardiomyopathies

Author

Riva, Alessandra, primary, Sturla, Francesco, additional, Pica, Silvia, additional, Camporeale, Antonia, additional, Tondi, Lara, additional, Saitta, Simone, additional, Caimi, Alessandro, additional, Giese, Daniel, additional, Palladini, Giovanni, additional, Milani, Paolo, additional, Castelvecchio, Serenella, additional, Menicanti, Lorenzo, additional, Redaelli, Alberto, additional, Lombardi, Massimo, additional, and Votta, Emiliano, additional

Published
2022
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35. 366 The use of dedicated long-axis views focused on the left atrium improves the accuracy of left atrial volumes and function measured by cardiovascular magnetic resonance

Author

Menè, Roberto, primary, Tondi, Lara, additional, Badano, Luigi, additional, Torlasco, Camilla, additional, Florescu, Diana Ruxandra, additional, Volpato, Valentina, additional, Parati, Gianfranco, additional, Giannattasio, Cristina, additional, Lombardi, Massimo, additional, and Muraru, Denisa, additional

Published
2021
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37. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy

Author

Bernardini, Andrea, Camporeale, Antonia, Pieroni, Maurizio, Pieruzzi, Federico, Figliozzi, Stefano, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Carubbi, Francesca, Battaglia, Yuri, Graziani, Francesca, Pica, Silvia, Tondi, Lara, Chow, Kelvin, Boveri, Sara, Olivotto, Iacopo, Lombardi, Massimo, Graziani, Francesca (ORCID:0000-0002-4520-5689), Bernardini, Andrea, Camporeale, Antonia, Pieroni, Maurizio, Pieruzzi, Federico, Figliozzi, Stefano, Lusardi, Paola, Spada, Marco, Mignani, Renzo, Burlina, Alessandro, Carubbi, Francesca, Battaglia, Yuri, Graziani, Francesca, Pica, Silvia, Tondi, Lara, Chow, Kelvin, Boveri, Sara, Olivotto, Iacopo, Lombardi, Massimo, and Graziani, Francesca (ORCID:0000-0002-4520-5689)

Published
2020

39. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy

Author

Bernardini, Andrea, primary, Camporeale, Antonia, additional, Pieroni, Maurizio, additional, Pieruzzi, Federico, additional, Figliozzi, Stefano, additional, Lusardi, Paola, additional, Spada, Marco, additional, Mignani, Renzo, additional, Burlina, Alessandro, additional, Carubbi, Francesca, additional, Battaglia, Yuri, additional, Graziani, Francesca, additional, Pica, Silvia, additional, Tondi, Lara, additional, Chow, Kelvin, additional, Boveri, Sara, additional, Olivotto, Iacopo, additional, and Lombardi, Massimo, additional

Published
2020
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41. Impact of multipoint pacing on projected battery longevity in cardiac resynchronization therapy. An IRON‐MPP study sub‐analysis

Author

Forleo, Giovanni B., primary, Gasperetti, Alessio, additional, Ricciardi, Danilo, additional, Curnis, Antonio, additional, Bertaglia, Emanuele, additional, Calò, Leonardo, additional, Pignalberi, Carlo, additional, Calzolari, Vittorio, additional, Ribatti, Valentina, additional, Lavalle, Carlo, additional, Potenza, Domenico, additional, Tondi, Lara, additional, Natale, Veronica, additional, Notarstefano, Pasquale, additional, Viecca, Maurizio, additional, Morani, Giovanni, additional, Biffi, Mauro, additional, Giammaria, Massimo, additional, Zanon, Francesco, additional, and Santini, Luca, additional

Published
2019
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42. Unveiling the Distinctive Phenotypes of Arrhythmic Mitral Valve Prolapse by High-density Myocardial Strain Imaging and Late-gadolinium-enhancement Microstructure Analysis

Author

Maio, Silvana Di, Zaidi, Hassan, Vandenberk, Bert, Censi, Stefano, Figliozzi, Stefano, Tondi, Lara, Lombardi, Massimo, Aquaro, Giovanni Donato, Andreini, Daniele, Bauer, Klemens B, Di Maio, Silvana, Squeri, Angelo, Torlasco, Camilla, Galian, Laura, Mushtaq, Saima, Rodríguez Palomares, José F, Marchenko, Oksana, Pontone, Gianluca, Monti, Lorenzo, Giulia Pavon, Anna, Teske, Arco J, Florian, Anca, Agricola, Eustachio, Francone, Marco, Badano, Luigi P, Yilmaz, Ali, Schwitter, Juerg, Georgiopoulos, Georgios, Lamata, Pablo, Grapsa, Julia, Leiner, Tim, Bogaert, Jan, Bishop, Martin, and Giorgio Masci, Pier

Published
2024
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45. Real-life indications to ivabradine treatment for heart rate optimization in patients with chronic systolic heart failure

Author

Lara Tondi, Marco Gemma, Giuseppe Pinto, Alberto Margonato, Roberto Spoladore, Massimo Slavich, Claudia Montanaro, Gabriele Fragasso, Anna Salerno, Cosmo Godino, Tondi, Lara, Fragasso, Gabriele, Spoladore, Roberto, Pinto, Giuseppe, Gemma, Marco, Slavich, Massimo, Godino, Cosmo, Salerno, Anna, Montanaro, Claudia, and Margonato, Alberto

Subjects
Male, medicine.medical_specialty, Adrenergic beta-Antagonists, Population, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Internal medicine, Natriuretic Peptide, Brain, Heart rate, medicine, Humans, Ivabradine, Sinus rhythm, 030212 general & internal medicine, education, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, Ejection fraction, business.industry, Cardiovascular Agents, Stroke Volume, General Medicine, Stroke volume, Middle Aged, medicine.disease, Peptide Fragments, Hospitalization, Echocardiography, Heart failure, Chronic Disease, Cardiovascular agent, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Heart Failure, Systolic, medicine.drug
Abstract

Ivabradine is a selective and specific inhibitor of If current. With its pure negative chronotropic action, it is recommended by European Society of Cardiology and American College of Cardiology/American Heart Association guidelines in symptomatic heart failure patients (NYHA ≥ 2) with ejection fraction 35% or less, sinus rhythm and heart rate (HR) at least 70 bpm, despite maximally titrated β-blocker therapy. Data supporting this indication mainly derive from the SHIFT study, in which ivabradine reduced the combined endpoint of mortality and hospitalization, despite the fact that only 26% of patients enrolled were on optimal β-blocker doses. The aim of the present analysis is to establish the real-life eligibility for ivabradine in a population of patients with systolic heart failure, regularly attending a single heart failure clinic and treated according to guideline-directed medical therapy (GDMT). The clinical cards of 308 patients with heart failure with reduced ejection fraction (HFrEF) through a 68-month period of observation were retrospectively analyzed. GDMT, including β-blocker up-titration to maximal tolerated dose, was implemented during consecutive visits at variable intervals. Demographic, clinical and echocardiographic data were collected at each visit, together with 12-leads ECG and N-terminal pro-B-type natriuretic peptide levels. Out of 308 analyzed HFrEF patients, 220 (71%) were on effective β-blocker therapy, up-titrated to effective/maximal tolerated dose (55 ± 28% of maximal dose) (HR 67 ± 10 bpm). Among the remaining 88 patients, 10 (3.2%) were on maximally tolerated β blocker and ivabradine; 21 patients (6.8%), despite being on maximal tolerated β-blocker dose, had still HR ≥70 bpm, ejection fraction 35% or less and were symptomatic NYHA ≥2, being therefore eligible for ivabradine treatment. The remaining 57 (18%) patients were not on β blocker due to either intolerance or major contraindications. Among them, 13 (4%) were taking ivabradine alone. Of the final 44 (14%) patients, 27 (9%) showed an inadequate HR control (74 ± 6 bpm). Of these, only eight (3%) patients resulted to be eligible for ivabradine introduction according to HR and ejection fraction parameters. Overall ivabradine was indicated in 52 patients (16.8%) out of 308 enrolled.In conclusion, in a carefully managed population of patients with moderate and stable HFrEF, in which optimal GDMT is properly attained, indication to ivabradine treatment is around 17%.

Published
2018

46. Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine Learning Analysis Using a Multicenter Cardiac MRI Registry.

Author

Akyea RK, Figliozzi S, Lopes PM, Bauer KB, Moura-Ferreira S, Tondi L, Mushtaq S, Censi S, Pavon AG, Bassi I, Galian-Gay L, Teske AJ, Biondi F, Filomena D, Stylianidis V, Torlasco C, Muraru D, Monney P, Quattrocchi G, Maestrini V, Agati L, Monti L, Pedrotti P, Vandenberk B, Squeri A, Lombardi M, Ferreira AM, Schwitter J, Aquaro GD, Pontone G, Chiribiri A, Rodríguez Palomares JF, Yilmaz A, Andreini D, Florian AR, Francone M, Leiner T, Abecasis J, Badano LP, Bogaert J, Georgiopoulos G, and Masci PG

Subjects
Humans, Female, Male, Middle Aged, Retrospective Studies, Registries, Magnetic Resonance Imaging, Cine methods, Arrhythmias, Cardiac diagnostic imaging, Arrhythmias, Cardiac physiopathology, Adult, Magnetic Resonance Imaging, Mitral Valve Prolapse diagnostic imaging, Unsupervised Machine Learning, Phenotype
Abstract

Purpose To use unsupervised machine learning to identify phenotypic clusters with increased risk of arrhythmic mitral valve prolapse (MVP). Materials and Methods This retrospective study included patients with MVP without hemodynamically significant mitral regurgitation or left ventricular (LV) dysfunction undergoing late gadolinium enhancement (LGE) cardiac MRI between October 2007 and June 2020 in 15 European tertiary centers. The study end point was a composite of sustained ventricular tachycardia, (aborted) sudden cardiac death, or unexplained syncope. Unsupervised data-driven hierarchical k -mean algorithm was utilized to identify phenotypic clusters. The association between clusters and the study end point was assessed by Cox proportional hazards model. Results A total of 474 patients (mean age, 47 years ± 16 [SD]; 244 female, 230 male) with two phenotypic clusters were identified. Patients in cluster 2 (199 of 474, 42%) had more severe mitral valve degeneration (ie, bileaflet MVP and leaflet displacement), left and right heart chamber remodeling, and myocardial fibrosis as assessed with LGE cardiac MRI than those in cluster 1. Demographic and clinical features (ie, symptoms, arrhythmias at Holter monitoring) had negligible contribution in differentiating the two clusters. Compared with cluster 1, the risk of developing the study end point over a median follow-up of 39 months was significantly higher in cluster 2 patients (hazard ratio: 3.79 [95% CI: 1.19, 12.12], P = .02) after adjustment for LGE extent. Conclusion Among patients with MVP without significant mitral regurgitation or LV dysfunction, unsupervised machine learning enabled the identification of two phenotypic clusters with distinct arrhythmic outcomes based primarily on cardiac MRI features. These results encourage the use of in-depth imaging-based phenotyping for implementing arrhythmic risk prediction in MVP. Keywords: MR Imaging, Cardiac, Cardiac MRI, Mitral Valve Prolapse, Cluster Analysis, Ventricular Arrhythmia, Sudden Cardiac Death, Unsupervised Machine Learning Supplemental material is available for this article. © RSNA, 2024.

Published
2024
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47. Left atrial dysfunction predicts left ventricular remodeling in patients with preserved ejection fraction after acute ST-elevation myocardial infarction.

Author

Attanasio A, Tondi L, Castelvecchio S, Pazzanese V, Palmisano A, Esposito A, Ameri P, Canale C, Cappelletti A, Alberti LP, Tavano D, Camporotondo R, Costantino I, Campodonico J, Pontone G, Villani A, Gallone GP, Montone RA, Niccoli G, Gargiulo P, Punzo B, Vicenzi M, Carugo S, Disabato G, Guida G, Camporeale A, Carrafiello G, Spagnolo P, Menicanti L, Ambrosio G, Piepoli M, Lombardi M, and Camici PG

Published
2024
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