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263 results on '"Tomsic, Matija"'

2. Drug effectiveness of 2nd and 3rd TNF inhibitors in psoriatic arthritis – relationship with the reason for withdrawal from the previous treatment

Author

Ørnbjerg, Lykke Midtbøll, Brahe, Cecilie Heegaard, Linde, Louise, Jacobsson, Lennart, Nissen, Michael J., Kristianslund, Eirik Klami, Santos, Maria José, Nordström, Dan, Rotar, Ziga, Gudbjornsson, Bjorn, Onen, Fatos, Codreanu, Catalin, Lindström, Ulf, Möller, Burkhard, Kvien, Tore K., Barcelos, Anabela, Eklund, Kari K., Tomšič, Matija, Love, Thorvardur Jon, Can, Gercek, Ionescu, Ruxandra, Loft, Anne Gitte, Mann, Herman, Pavelka, Karel, van de Sande, Marleen, van der Horst-Bruinsma, I.E., Suarez, Manuel Pombo, Sánchez-Piedra, Carlos, Macfarlane, Gary J., Iannone, Florenzo, Michelsen, Brigitte, Hyldstrup, Lise Hejl, Krogh, Niels Steen, Østergaard, Mikkel, and Hetland, Merete Lund

Published
2024
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3. Molecular maps of synovial cells in inflammatory arthritis using an optimized synovial tissue dissociation protocol

Author

Edalat, Sam G., Gerber, Reto, Houtman, Miranda, Lückgen, Janine, Teixeira, Rui Lourenço, Palacios Cisneros, Maria del Pilar, Pfanner, Tamara, Kuret, Tadeja, Ižanc, Nadja, Micheroli, Raphael, Polido-Pereira, Joaquim, Saraiva, Fernando, Lingam, Swathi, Burki, Kristina, Burja, Blaž, Pauli, Chantal, Rotar, Žiga, Tomšič, Matija, Čučnik, Saša, Fonseca, João Eurico, Distler, Oliver, Calado, Ângelo, Romão, Vasco C., Ospelt, Caroline, Sodin-Semrl, Snežna, Robinson, Mark D., and Frank Bertoncelj, Mojca

Published
2024
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4. Solvation of Nonionic Poly(Ethylene Oxide) Surfactant Brij 35 in Organic and Aqueous-Organic Solvents

Author

Cerar, Jure, Jamnik, Andrej, Szilágyi, István, and Tomšič, Matija

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Hypothesis: By combining the experimental small- and wide-angle x-ray scattering (SWAXS) method with molecular dynamics simulations and the theoretical 'complemented-system approach' it is possible to obtain detailed information about the intra- and inter-molecular structure and dynamics of the solvation and hydration of the surfactant in organic and mixed solvents, e.g., of the nonionic surfactant Brij 35 (C12E23) in alcohols and aqueous alcohol-rich ternary systems. This first application of the complemented-system approach to the surfactant system will promote the use of this powerful methodology that is based on experimental and calculated SWAXS data in studies of colloidal systems. By applying high-performance computing systems, such an approach is readily available for studies in the colloidal domain. Experiments: SWAXS experiments and MD simulations were performed for binary Brij 35/alcohol and ternary Brij 35/water/alcohol systems with ethanol, n-butanol and n-hexanol as the organic solvent component at 25 {\deg}C. Findings: We confirmed the presence of solvated Brij 35 monomers in the studied organic media, revealed their preferential hydration and discussed their structural and dynamic features at the intra- and inter-molecular levels. Anisotropic effective surfactant molecular conformations were found. The influence of the hydrophobicity of the organic solvent on the hydration phenomena of surfactant molecules was explained., Comment: 31 pages, 6 figures, 1 table

Published
2021
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5. Differences and similarities between the EULAR/ASAS-EULAR and national recommendations for treatment of patients with psoriatic arthritis and axial spondyloarthritis across Europe

Author

Michelsen, Brigitte, Østergaard, Mikkel, Nissen, Michael John, Ciurea, Adrian, Möller, Burkhard, Ørnbjerg, Lykke Midtbøll, Zavada, Jakub, Glintborg, Bente, MacDonald, Alan, Laas, Karin, Nordström, Dan, Gudbjornsson, Bjorn, Iannone, Florenzo, Hellmand, Pasoon, Kvien, Tore Kristian, Rodrigues, Ana Maria, Codreanu, Catalin, Rotar, Ziga, Castrejón Fernández, Isabel, Wallman, Johan Karlsson, Vencovsky, Jiri, Loft, Anne Gitte, Heddle, Maureen, Vorobjov, Sigrid, Hokkanen, Anna-Mari, Gröndal, Gerdur, Sebastiani, Marco, van de Sande, Marleen, Kristianslund, Eirik Klami, Santos, Maria José, Mogosan, Corina, Tomsic, Matija, Díaz-González, Federico, Di Giuseppe, Daniela, and Hetland, Merete Lund

Published
2023
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6. Structural, Rheological and Dynamic Aspects of Hydrogen-Bonding Molecular Liquids: Aqueous Solutions of Hydrotropic tert-Butyl Alcohol

Author

Cerar, Jure, Jamnik, Andrej, Pethes, Ildikó, Temleitner, László, Pusztai, László, and Tomsic, Matija

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Hypothesis: The structural details, viscosity trends and dynamic phenomena in t-butanol/water solutions are closely related on the molecular scales across the entire composition range. Utilizing the experimental small- and wide-angle x-ray scattering (SWAXS) method, molecular dynamics (MD) simulations and the complemented-system approach method developed in our group it is possible to comprehensively describe the structure-viscosity-dynamics relationship in such structurally versatile hydrogen-bonded molecular liquids, as well as in similar, self-assembling systems with pronounced molecular and supramolecular structures at the intra-, inter-, and supra-molecular scales. Experiments: The SWAXS and x-ray diffraction experiments and MD simulations were performed for aqueous t-butanol solutions at 25 {\deg}C. Literature viscosity and self-diffusion data were also used. Findings: The interpretive power of the proposed scheme was demonstrated by the extensive and diverse results obtained for aqueous t-butanol solutions across the whole concentration range. Four composition ranges with qualitatively different structures and viscosity trends were revealed. The experimental and calculated zero-shear viscosities and molecular self-diffusion coefficients were successfully related to the corresponding structural details. The hydrogen bonds, that were, along with hydrophobic effects, recognized as the most important driving force for the formation of t-butanol aggregates, show intriguing lifetime trends and thermodynamic properties of their formation., Comment: Main manuscript file AND Supplemental Information, united in one file

Published
2019
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7. Unexpected composition dependence of the first sharp diffraction peak in an alcohol-aldehyde liquid mixture: n-pentanol and pentanal

Author

Pethes, Ildikó, Temleitner, László, Tomšič, Matija, Jamnik, Andrej, and Pusztai, László

Subjects
Physics - Chemical Physics, Condensed Matter - Soft Condensed Matter
Abstract

The total scattering structure factors of pure liquid n-pentanol, pentanal, and 5 of their mixtures, as determined by high energy synchrotron X-ray diffraction experiments, are presented. For the interpretation of measured data, molecular dynamics computer simulations are performed, utilizing 'all-atom' type force fields. The diffraction signals in general resemble each other over most of the monitored Q range above 1 ${\AA}^{-1}$, but the absolute values of the intensities of the small-angle scattering maximum ('pre-peak', 'first sharp diffraction peak'), around 0.6 ${\AA}^{-1}$, change in an unexpected fashion, non-linearly with the composition. MD simulations are not able to reproduce this low-Q behavior; on the other hand, they do reproduce the experimental diffraction data above 1 ${\AA}^{-1}$ rather accurately. Partial radial distribution functions are calculated based on the atomic coordinates in the simulated configurations. Inspection of the various O-O and O-H partial radial distribution functions clearly shows that both the alcoholic and the aldehydic oxygens form hydrogen bonds with the hydrogen atoms of the alcoholic OH-group., Comment: This is the pre-peer reviewed version of the article, which has been published in final form at Physica Status Solidi B

Published
2018
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8. X-ray diffraction and computer simulation studies of the structure of liquid aliphatic aldehydes: from propanal to nonanal

Author

Pethes, Ildikó, Temleitner, László, Tomšič, Matija, Jamnik, Andrej, and Pusztai, László

Subjects
Physics - Chemical Physics, Condensed Matter - Soft Condensed Matter
Abstract

Synchrotron X-ray diffraction experiments and molecular dynamics simulations have been performed on simple aliphatic aldehydes, from propanal to nonanal. The performance of the OPLS all-atom interaction potential model for aldehydes has been assessed via direct comparison of simulated and experimental total scattering structure factors. In general, MD results reproduce the experimental data at least semi-quantitatively. However, a slight mismatch can be observed between the two datasets in terms of the position of the main diffraction maxima. Partial radial distribution functions have also been calculated from the simulation results. Clear differences could be detected between the various O-H partial radial distribution functions, depending on whether the H atom is attached to the carbon atom that is doubly bonded to the oxygen atom of the aldehyde group or not., Comment: This is the pre-peer reviewed version of the article, which has been published in final form at Physica Status Solidi B

Published
2018
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9. Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration

Author

Ørnbjerg, Lykke M., Linde, Louise, Georgiadis, Stylianos, Rasmussen, Simon H., Lindström, Ulf, Askling, Johan, Michelsen, Brigitte, Giuseppe, Daniela Di, Wallman, Johan K., Pavelka, Karel, Závada, Jakub, Nissen, Michael J., Jones, Gareth T., Relas, Heikki, Pirilä, Laura, Tomšič, Matija, Rotar, Ziga, Geirsson, Arni Jon, Gudbjornsson, Bjorn, Kristianslund, Eirik K., van sder Horst-Bruinsma, Irene, Loft, Anne Gitte, Laas, Karin, Iannone, Florenzo, Corrado, Addolorata, Ciurea, Adrian, Santos, Maria J., Santos, Helena, Codreanu, Catalin, Akkoc, Nurullah, Gunduz, Ozgul S., Glintborg, Bente, Østergaard, Mikkel, and Hetland, Merete Lund

Published
2022
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10. Janus kinase inhibitors and their use in non-infectious orbital inflammatory disorders: new treatment possibilities? A case series.

Author

Vidic Krhlikar, Nina, Tomsic, Matija, Jaki Mekjavic, Polona, Klobucar, Pia, Bregar, Janez, Surlan Popovic, Katarina, and Valentincic, Natasa

Subjects
*ANTIRHEUMATIC agents, *KINASE inhibitors, *LIVER enzymes, *SCLERITIS, *BARICITINIB
Abstract

We present a patient with isolated autoimmune anterior scleritis and a patient with nonspecific orbital inflammation (NSOI). Both patients were treated with systemic corticosteroids during multiple recurrences, with the addition of various disease-modifying antirheumatic drugs (DMARDs), including biologics, in the case of scleritis, resulting in complications and local adverse events. Both patients were subsequently effectively managed using Janus kinase inhibitors (JAK-i), specifically baricitinib and tofacitinib without relapses of inflammation during the follow-up of more than one year. Only a slight transient increase in liver enzymes was reported in a patient with scleritis and no serious side effects. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Real‐World Six‐ and Twelve‐Month Drug Retention, Remission, and Response Rates of Secukinumab in 2,017 Patients With Psoriatic Arthritis in Thirteen European Countries

Author

Michelsen, Brigitte, Georgiadis, Stylianos, Di Giuseppe, Daniela, Loft, Anne G., Nissen, Michael J., Iannone, Florenzo, Pombo‐Suarez, Manuel, Mann, Herman, Rotar, Ziga, Eklund, Kari K., Kvien, Tore K., Santos, Maria J., Gudbjornsson, Bjorn, Codreanu, Catalin, Yilmaz, Sema, Wallman, Johan K., Brahe, Cecilie H., Möller, Burkhard, Favalli, Ennio G., Sánchez‐Piedra, Carlos, Nekvindova, Lucie, Tomsic, Matija, Trokovic, Nina, Kristianslund, Eirik K., Santos, Helena, Löve, Thorvardur J., Ionescu, Ruxandra, Pehlivan, Yavuz, Jones, Gareth T., van der Horst‐Bruinsma, Irene, Ørnbjerg, Lykke M., Østergaard, Mikkel, and Hetland, Merete L.

Published
2022
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19. The Complemented System Approach: A Novel Method for Calculating the X-ray Scattering from Computer Simulations

Author

Lajovic, Andrej, Tomšič, Matija, and Jamnik, Andrej

Subjects
Condensed Matter - Statistical Mechanics, Physics - Chemical Physics
Abstract

In this paper, we review the main problem concerning the calculation of X-ray scattering of simulated model systems, namely their finite size. A novel method based on the Rayleigh-Debye-Gans approximation was derived, which allows sidestepping this issue by complementing the missing surroundings of each particle with an average image of the system. The method was designed to operate directly on particle configurations without an intermediate step (e.g., calculation of pair distribution functions): in this way, all information contained in the configurations was preserved. A comparison of the results against those of other known methods showed that the new method combined several favourable properties: an arbitrary q-scale, scattering curves free of truncation artifacts and good behaviour down to the theoretical lower limit of the q-scale. A test of computational efficiency was also performed to establish a relative scale between the speeds of all known methods: the reciprocal lattice approach, the brute force method, the Fourier transform approach and the newly presented complemented system approach., Comment: 6 pages, 5 figures. Copyright 2010 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in The Journal of Chemical Physics and may be found at http://link.aip.org/link/?jcp/133/174123

Published
2010
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26. Corrigendum to ‘Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: data from the EuroSpA collaboration’ [Seminars in Arthritis and Rheumatism 56 (2022) 1-13/152081]

Author

Ørnbjerg, Lykke M., Linde, Louise, Georgiadis, Stylianos, Rasmussen, Simon H., Lindström, Ulf, Askling, Johan, Michelsen, Brigitte, Giuseppe, Daniela Di, Wallman, Johan K., Pavelka, Karel, Závada, Jakub, Nissen, Michael J., Jones, Gareth T., Relas, Heikki, Pirilä, Laura, Tomšič, Matija, Rotar, Ziga, Geirsson, Arni Jon, Gudbjornsson, Bjorn, Kristianslund, Eirik K., van der Horst-Bruinsma, Irene, Loft, Anne Gitte, Laas, Karin, Iannone, Florenzo, Corrado, Addolorata, Ciurea, Adrian, Santos, Maria J., Santos, Helena, Codreanu, Catalin, Akkoc, Nurullah, Gunduz, Ozgul S., Glintborg, Bente, Østergaard, Mikkel, and Hetland, Merete Lund

Published
2023
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32. The impact of a csDMARD in combination with a TNF inhibitor on drug retention and clinical remission in axial spondyloarthritis

Author

Nissen, Michael, Delcoigne, Bénédicte, Di Giuseppe, Daniela, Jacobsson, Lennart, Hetland, Merete Lund, Ciurea, Adrian, Nekvindova, Lucie, Iannone, Florenzo, Akkoc, Nurullah, Sokka-Isler, Tuulikki, Fagerli, Karen Minde, Santos, Maria Jose, Codreanu, Catalin, Pombo-Suarez, Manuel, Rotar, Ziga, Gudbjornsson, Bjorn, van der Horst-Bruinsma, Irene, Loft, Anne Gitte, Möller, Burkhard, Mann, Herman, Conti, Fabrizio, Yildirim Cetin, Gozde, Relas, Heikki, Michelsen, Brigitte, Avila Ribeiro, Pedro, Ionescu, Ruxandra, Sanchez-Piedra, Carlos, Tomsic, Matija, Geirsson, Árni Jón, Askling, Johan, Glintborg, Bente, Lindström, Ulf, Nissen, Michael, Delcoigne, Bénédicte, Di Giuseppe, Daniela, Jacobsson, Lennart, Hetland, Merete Lund, Ciurea, Adrian, Nekvindova, Lucie, Iannone, Florenzo, Akkoc, Nurullah, Sokka-Isler, Tuulikki, Fagerli, Karen Minde, Santos, Maria Jose, Codreanu, Catalin, Pombo-Suarez, Manuel, Rotar, Ziga, Gudbjornsson, Bjorn, van der Horst-Bruinsma, Irene, Loft, Anne Gitte, Möller, Burkhard, Mann, Herman, Conti, Fabrizio, Yildirim Cetin, Gozde, Relas, Heikki, Michelsen, Brigitte, Avila Ribeiro, Pedro, Ionescu, Ruxandra, Sanchez-Piedra, Carlos, Tomsic, Matija, Geirsson, Árni Jón, Askling, Johan, Glintborg, Bente, and Lindström, Ulf

Abstract

OBJECTIVES: Many axial spondylarthritis (axSpA) patients receive a conventional synthetic DMARD (csDMARD) in combination with a TNF inhibitor (TNFi). However, the value of this co-therapy remains unclear. The objectives were to describe the characteristics of axSpA patients initiating a first TNFi as monotherapy compared with co-therapy with csDMARD, to compare one-year TNFi retention and remission rates, and to explore the impact of peripheral arthritis. METHODS: Data was collected from 13 European registries. One-year outcomes included TNFi retention and hazard ratios (HR) for discontinuation with 95% CIs. Logistic regression was performed with adjusted odds ratios (OR) of achieving remission (Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP < 1.3 and/or BASDAI < 2) and stratified by treatment. Inter-registry heterogeneity was assessed using random-effect meta-analyses, combined results were presented when heterogeneity was not significant. Peripheral arthritis was defined as ≥1 swollen joint at baseline (=TNFi start). RESULTS: Amongst 24 171 axSpA patients, 32% received csDMARD co-therapy (range across countries: 13.5% to 71.2%). The co-therapy group had more baseline peripheral arthritis and higher CRP than the monotherapy group. One-year TNFi-retention rates (95% CI): 79% (78, 79%) for TNFi monotherapy vs 82% (81, 83%) with co-therapy (P < 0.001). Remission was obtained in 20% on monotherapy and 22% on co-therapy (P < 0.001); adjusted OR of 1.16 (1.07, 1.25). Remission rates at 12 months were similar in patients with/without peripheral arthritis. CONCLUSION: This large European study of axial SpA patients showed similar one-year treatment outcomes for TNFi monotherapy and csDMARD co-therapy, although considerable heterogeneity across countries limited the identification of certain subgroups (e.g. peripheral arthritis) that may benefit from co-therapy.

Published
2022

33. European bio-naïve spondyloarthritis patients initiating TNF inhibitor:time trends in baseline characteristics, treatment retention and response

Author

Christiansen, Sara Nysom, Ørnbjerg, Lykke Midtbøll, Rasmussen, Simon Horskjær, Loft, Anne Gitte, Askling, Johan, Iannone, Florenzo, Zavada, Jakub, Michelsen, Brigitte, Nissen, Michael, Onen, Fatos, Santos, Maria Jose, Pombo-Suarez, Manuel, Relas, Heikki, Macfarlane, Gary J., Tomsic, Matija, Codreanu, Catalin, Gudbjornsson, Bjorn, Van der Horst-Bruinsma, Irene, Di Giuseppe, Daniela, Glintborg, Bente, Gremese, Elisa, Pavelka, Karel, Kristianslund, Eirik Klami, Ciurea, Adrian, Akkoc, Nurullah, Barcelos, Anabela, Sánchez-Piedra, Carlos, Peltomaa, Ritva, Jones, Gareth T., Rotar, Ziga, Ionescu, Ruxandra, Grondal, Gerdur, Van de Sande, Marleen G.H., Laas, Karin, Østergaard, Mikkel, Hetland, Merete L., Christiansen, Sara Nysom, Ørnbjerg, Lykke Midtbøll, Rasmussen, Simon Horskjær, Loft, Anne Gitte, Askling, Johan, Iannone, Florenzo, Zavada, Jakub, Michelsen, Brigitte, Nissen, Michael, Onen, Fatos, Santos, Maria Jose, Pombo-Suarez, Manuel, Relas, Heikki, Macfarlane, Gary J., Tomsic, Matija, Codreanu, Catalin, Gudbjornsson, Bjorn, Van der Horst-Bruinsma, Irene, Di Giuseppe, Daniela, Glintborg, Bente, Gremese, Elisa, Pavelka, Karel, Kristianslund, Eirik Klami, Ciurea, Adrian, Akkoc, Nurullah, Barcelos, Anabela, Sánchez-Piedra, Carlos, Peltomaa, Ritva, Jones, Gareth T., Rotar, Ziga, Ionescu, Ruxandra, Grondal, Gerdur, Van de Sande, Marleen G.H., Laas, Karin, Østergaard, Mikkel, and Hetland, Merete L.

Abstract

OBJECTIVES: To investigate time trends in baseline characteristics and retention, remission and response rates in bio-naïve axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients initiating TNF inhibitor (TNFi) treatment. METHODS: Prospectively collected data on bio-naïve axSpA and PsA patients from routine care in 15 European countries were pooled. Three cohorts were defined according to year of TNFi initiation: A (1999-2008), B (2009-2014) and C (2015-2018). Retention, remission and response rates were assessed at 6, 12 and 24 months. RESULTS: In total, 27 149 axSpA and 17 446 PsA patients were included. Cohort A patients had longer disease duration compared with B and C. In axSpA, cohort A had the largest proportion of male and HLA-B27 positive patients. In PsA, baseline disease activity was highest in cohort A. Retention rates in axSpA/PsA were highest in cohort A and differed only slightly between B and C. For all cohorts, disease activity decreased markedly from 0 to 6 months. In axSpA, disease activity at 24 months was highest in cohort A, where also remission and response rates were lowest. In PsA, remission rates at 6 and 12 months tended to be lowest in cohort A. Response rates were at all time points comparable across cohorts, and less between-cohort disease activity differences were seen at 24 months. CONCLUSION: Our findings indicate that over the past decades, clinicians have implemented more aggressive treatment strategies in spondyloarthritis. This was illustrated by shorter disease duration at treatment initiation, decreased retention rates and higher remission rates during recent years.

Published
2022

34. The impact of a csDMARD in combination with a TNF inhibitor on drug retention and clinical remission in axial spondyloarthritis

Author

Nissen, Michael, primary, Delcoigne, Bénédicte, additional, Di Giuseppe, Daniela, additional, Jacobsson, Lennart, additional, Hetland, Merete Lund, additional, Ciurea, Adrian, additional, Nekvindova, Lucie, additional, Iannone, Florenzo, additional, Akkoc, Nurullah, additional, Sokka-Isler, Tuulikki, additional, Fagerli, Karen Minde, additional, Santos, Maria Jose, additional, Codreanu, Catalin, additional, Pombo-Suarez, Manuel, additional, Rotar, Ziga, additional, Gudbjornsson, Bjorn, additional, van der Horst-Bruinsma, Irene, additional, Loft, Anne Gitte, additional, Möller, Burkhard, additional, Mann, Herman, additional, Conti, Fabrizio, additional, Yildirim Cetin, Gozde, additional, Relas, Heikki, additional, Michelsen, Brigitte, additional, Avila Ribeiro, Pedro, additional, Ionescu, Ruxandra, additional, Sanchez-Piedra, Carlos, additional, Tomsic, Matija, additional, Geirsson, Árni Jón, additional, Askling, Johan, additional, Glintborg, Bente, additional, and Lindström, Ulf, additional

Published
2022
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36. Defining disease activity states and clinically meaningful improvement in primary Sjögrenʼs syndrome with EULAR primary Sjögrenʼs syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)

Author

Seror, Raphaèle, Bootsma, Hendrika, Saraux, Alain, Bowman, Simon J, Theander, Elke, Brun, Johan G, Baron, Gabriel, Le Guern, Véronique, Devauchelle-Pensec, Valérie, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Tzioufas, Athanasios, Gottenberg, Jacques-Eric, Solans Laqué, Roser, Mandl, Thomas, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Priori, Roberta, Bartoloni, Elena, Goeb, Vincent, Praprotnik, Sonja, Sumida, Takayuki, Nishiyama, Sumusu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Meiners, Petra, Brito-Zerón, Pilar, Vitali, Claudio, Mariette, Xavier, Gerli, Roberto, Kallenberg, Cees, Brun, Johan G, De Vita, Salvatore, Devauchelle, Valerie, Gottenberg, Jacques Eric, Demoulins, Frederic, Montecucco, Carlomaurizio, Tomsic, Matija, Casals, Manel Ramos, Scofield, Hal, Valesini, Guido, Devauchelle, Valerie, Saraux, Alain, Dubost, Jean-Jacques, Fauchais, Anne-Laure, Sibilia, Jean, Hayem, Gilles, Hatron, Pierre- Yves, Larroche, Claire, Guern, Veronique Le, Puéchal, Xavier, Morel, Jacques, Pedriger, Aleth, Rist, Stephanie, Sene, Damien, and Vittecoq, Olivier

Published
2016
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37. European bio-naïve spondyloarthritis patients initiating TNF inhibitor: time trends in baseline characteristics, treatment retention and response

Author

Christiansen, Sara Nysom, primary, Ørnbjerg, Lykke Midtbøll, additional, Rasmussen, Simon Horskjær, additional, Loft, Anne Gitte, additional, Askling, Johan, additional, Iannone, Florenzo, additional, Zavada, Jakub, additional, Michelsen, Brigitte, additional, Nissen, Michael, additional, Onen, Fatos, additional, Santos, Maria Jose, additional, Pombo-Suarez, Manuel, additional, Relas, Heikki, additional, Macfarlane, Gary J, additional, Tomsic, Matija, additional, Codreanu, Catalin, additional, Gudbjornsson, Bjorn, additional, Van der Horst-Bruinsma, Irene, additional, Di Giuseppe, Daniela, additional, Glintborg, Bente, additional, Gremese, Elisa, additional, Pavelka, Karel, additional, Kristianslund, Eirik Klami, additional, Ciurea, Adrian, additional, Akkoc, Nurullah, additional, Barcelos, Anabela, additional, Sánchez-Piedra, Carlos, additional, Peltomaa, Ritva, additional, Jones, Gareth T, additional, Rotar, Ziga, additional, Ionescu, Ruxandra, additional, Grondal, Gerdur, additional, Van de Sande, Marleen G H, additional, Laas, Karin, additional, Østergaard, Mikkel, additional, and Hetland, Merete L, additional

Published
2021
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39. Validation of EULAR primary Sjögrenʼs syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

Author

Seror, Raphaèle, Theander, Elke, Brun, Johan G, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Bootsma, Hendrika, Tzioufas, Athanasios, Solans-Laqué, Roser, Mandl, Thomas, Gottenberg, Jacques-Eric, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Valesini, Guido, Bartoloni, Elena, Saraux, Alain, Tomsic, Matija, Sumida, Takayuki, Nishiyama, Susumu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Bowman, Simon J, Gerli, Roberto, Kallenberg, Cees, Meiners, Petra, De Vita, Salvatore, Devauchelle, Valerie, Demoulins, Frederic, Montecucco, Carlomaurizio, Praprotnik, Sonja, and Scofield, Hal

Published
2015
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43. Validation of the classification criteria for cryoglobulinaemic vasculitis

Author

Quartuccio, Luca, Isola, Miriam, Corazza, Laura, Ramos-Casals, Manuel, Retamozo, Soledad, Ragab, Gaafar Mohamed, Zoheir, Mostafa Naguib, El-Menyawi, Manal Abdel-Moneim, Salem, Mohamed Nabil, Sansonno, Domenico, Ferraccioli, Gianfranco, Gremese, Elisa, Tzioufas, Athanasios, Voulgarelis, Michael, Vassilopoulos, Dimitris, Scarpato, Salvatore, Pipitone, Nicolò, Salvarani, Carlo, Guillevin, Loic, Terrier, Benjamin, Cacoub, Patrice, Filippini, Davide, Saccardo, Francesco, Gabrielli, Armando, Fraticelli, Paolo, Sebastiani, Marco, Tomsic, Matija, Tavoni, Antonio, Mazzaro, Cesare, Pioltelli, Pietro, Nishimoto, Norihiro, Scaini, Patrizia, Zignego, Anna Linda, Ferri, Clodoveo, Monti, Giuseppe, Pietrogrande, Maurizio, Bombardieri, Stefano, Galli, Massimo, and De Vita, Salvatore

Published
2014
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44. Variations in criteria regulating treatment with reimbursed biologic DMARDs across European countries. Are differences related to countryʼs wealth?

Author

Putrik, Polina, Ramiro, Sofia, Kvien, Tore K, Sokka, Tuulikki, Uhlig, Till, Boonen, Annelies, Collaku, Ledio, Harutyunyan, Ruzanna, Radner, Helga, Soroka, Nikolay, Mielants, Herman, Sokolovic, Sekib, Sapundzhiev, Lyubomir, Mayer, Miroslav, Charalambous, Paraskevi, Vencovsky, Jiri, Hetland, Merete Lund, Peets, Tõnu, Fautrel, Bruno, Letsveridze, Khatuna, Müller-Ladner, Ulf, Sidiropoulos, Prodromos, Péntek, Márta, Gröndal, Gerdur, McGrehan, Fiona, Bruno, Seriolo, Galymzhan, Togizbayev, Andersone, Daina, Butrimiene, Irena, Hirsch, Marco, Misevska-Percinkova, Snezana, Cassar, Karen, Deseatnicova, Elena, Mustur, Dusan, Raciborski, Filip, Tavares, Viviana, Berghea, Florian, Shirinsky, Ivan, Veljkovic, Miodrag, Kovarova, Maria, Tomsic, Matija, Sivera, Francisca, Petersson, Ingemar, Finckh, Axel, Sharipov, Shaydullo, Inanc, Nevsun, Dumenko, Tatyana, Verstappen, Suzanne, and Khudoberdiev, Hojimurad

Published
2014
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45. European bio-naïve spondyloarthritis patients initiating TNF inhibitor: time trends in baseline characteristics, treatment retention and response.

Author

Christiansen, Sara Nysom, Ørnbjerg, Lykke Midtbøll, Rasmussen, Simon Horskjær, Loft, Anne Gitte, Askling, Johan, Iannone, Florenzo, Zavada, Jakub, Michelsen, Brigitte, Nissen, Michael, Onen, Fatos, Santos, Maria Jose, Pombo-Suarez, Manuel, Relas, Heikki, Macfarlane, Gary J, Tomsic, Matija, Codreanu, Catalin, Gudbjornsson, Bjorn, Horst-Bruinsma, Irene Van der, Giuseppe, Daniela Di, and Glintborg, Bente

Subjects
PSORIATIC arthritis, STATISTICS, TIME, ANTI-inflammatory agents, SPONDYLOARTHROPATHIES, DESCRIPTIVE statistics, RESEARCH funding, DATA analysis, DISEASE remission, LONGITUDINAL method
Abstract

Objectives To investigate time trends in baseline characteristics and retention, remission and response rates in bio-naïve axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients initiating TNF inhibitor (TNFi) treatment. Methods Prospectively collected data on bio-naïve axSpA and PsA patients from routine care in 15 European countries were pooled. Three cohorts were defined according to year of TNFi initiation: A (1999–2008), B (2009–2014) and C (2015–2018). Retention, remission and response rates were assessed at 6, 12 and 24 months. Results In total, 27 149 axSpA and 17 446 PsA patients were included. Cohort A patients had longer disease duration compared with B and C. In axSpA, cohort A had the largest proportion of male and HLA-B27 positive patients. In PsA, baseline disease activity was highest in cohort A. Retention rates in axSpA/PsA were highest in cohort A and differed only slightly between B and C. For all cohorts, disease activity decreased markedly from 0 to 6 months. In axSpA, disease activity at 24 months was highest in cohort A, where also remission and response rates were lowest. In PsA, remission rates at 6 and 12 months tended to be lowest in cohort A. Response rates were at all time points comparable across cohorts, and less between-cohort disease activity differences were seen at 24 months. Conclusion Our findings indicate that over the past decades, clinicians have implemented more aggressive treatment strategies in spondyloarthritis. This was illustrated by shorter disease duration at treatment initiation, decreased retention rates and higher remission rates during recent years. [ABSTRACT FROM AUTHOR]

Published
2022
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46. DRUG RETENTION RATES AND TREATMENT OUTCOMES IN 1860 AXIAL SPONDYLOARTHRITIS PATIENTS TREATED WITH SECUKINUMAB IN ROUTINE CLINICAL PRACTICE IN 13 EUROPEAN COUNTRIES IN THE EUROSPA RESEARCH COLLABORATION NETWORK

Author

Ionescu, Ruxandra, ÖNEN, FATOŞ, Brahe, cecille, Georgiadis, Stylianos, Van, der Horst-Bruinsma, Jones, Gary, Geirsson, Arni Jon, Osterlund, Jenny, Sebastiani, Marco, Santos, Helena, Tomsic, Matija, Rotar, Ziga, Santos, MJ, Iannone, Fi, Hokkanen, AM, Gudbjornsson, Bjorn, Askling, Johan, Nissen, Micheal, Sexton, Joseph, AKAR, SERVET, Sanchez-Piedra, Carlos, Pavelka, Karel, [Michelsen, Brigitte, Lindstrom, Ulf, Codreanu, Catalin, Ciurea, Adrian, Zavada, Jacub, Loft, Anne Gitte, Pombo-Suarez, Manuel, and Kvien, Tore K

Published
2020

47. European bio-naïve spondyloarthritis patients initiating TNFi: Time trends in baseline characteristics, treatment retention and response

Author

Christiansen, Sara Nysom, Ørnbjerg, Lykke Midtbøll, Horskjær Rasmussen, Simon, Loft, Anne Gitte, Askling, Johan, Iannone, Florenzo, Zavada, Jakub, Michelsen, Brigitte, Nissen, Michael, Onen, Fato, Santos, Maria Jose, Pombo-Suarez, Manuel, Relas, Heikki, Macfarlane, Gary J, Tomsic, Matija, Codreanu, Catalin, Gudbjornsson, Bjorn, Van der Horst-Bruinsma, Irene, Di Giuseppe, Daniela, Glintborg, Bente, Gremese, Elisa, Pavelka, Karel, Kristianslund, Eirik Klami, Ciurea, Adrian, Akkoc, Nurullah, Barcelos, Anabela, Sánchez-Piedra, Carlo, Peltomaa, Ritva, Jones, Gareth T, Rotar, Ziga, Ionescu, Ruxandra, Grondal, Gerdur, Van de Sande, Marleen G H, Laas, Karin, Østergaard, Mikkel, Hetland, Merete L, Gremese, Elisa (ORCID:0000-0002-2248-1058), Christiansen, Sara Nysom, Ørnbjerg, Lykke Midtbøll, Horskjær Rasmussen, Simon, Loft, Anne Gitte, Askling, Johan, Iannone, Florenzo, Zavada, Jakub, Michelsen, Brigitte, Nissen, Michael, Onen, Fato, Santos, Maria Jose, Pombo-Suarez, Manuel, Relas, Heikki, Macfarlane, Gary J, Tomsic, Matija, Codreanu, Catalin, Gudbjornsson, Bjorn, Van der Horst-Bruinsma, Irene, Di Giuseppe, Daniela, Glintborg, Bente, Gremese, Elisa, Pavelka, Karel, Kristianslund, Eirik Klami, Ciurea, Adrian, Akkoc, Nurullah, Barcelos, Anabela, Sánchez-Piedra, Carlo, Peltomaa, Ritva, Jones, Gareth T, Rotar, Ziga, Ionescu, Ruxandra, Grondal, Gerdur, Van de Sande, Marleen G H, Laas, Karin, Østergaard, Mikkel, Hetland, Merete L, and Gremese, Elisa (ORCID:0000-0002-2248-1058)

Abstract

Objectives To investigate time trends in baseline characteristics and retention, remission and response rates in bio-naive axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients initiating TNF inhibitor (TNFi) treatment. Methods Prospectively collected data on bio-naive axSpA and PsA patients from routine care in 15 European countries were pooled. Three cohorts were defined according to year of TNFi initiation: A (1999-2008), B (2009-2014) and C (2015-2018). Retention, remission and response rates were assessed at 6, 12 and 24 months. Results In total, 27 149 axSpA and 17 446 PsA patients were included. Cohort A patients had longer disease duration compared with B and C. In axSpA, cohort A had the largest proportion of male and HLA-B27 positive patients. In PsA, baseline disease activity was highest in cohort A. Retention rates in axSpA/PsA were highest in cohort A and differed only slightly between B and C. For all cohorts, disease activity decreased markedly from 0 to 6 months. In axSpA, disease activity at 24 months was highest in cohort A, where also remission and response rates were lowest. In PsA, remission rates at 6 and 12 months tended to be lowest in cohort A. Response rates were at all time points comparable across cohorts, and less between-cohort disease activity differences were seen at 24 months. Conclusion Our findings indicate that over the past decades, clinicians have implemented more aggressive treatment strategies in spondyloarthritis. This was illustrated by shorter disease duration at treatment initiation, decreased retention rates and higher remission rates during recent years.

Published
2021

48. Structural properties of pure simple alcohols from ethanol, propanol, butanol, pentanol, to hexanol: Comparing Monte Carlo simulations with experimental SAXS data

Author

Tomsic, Matija, Jamnik, Andrej, Fritz-Popovski, Gerhard, Glatter, Otto, and Vlcek, Lukas

Subjects
Alcohols -- Chemical properties, Alcohols -- Structure, Monte Carlo method -- Usage, Intermolecular forces -- Research, Chemicals, plastics and rubber industries
Abstract

The configurational-bias Monte Carlo (MC) simulations and the small-angle X-ray scattering (SAXS) data are used together to analyze the structural properties of various pure simple alcohols, including ethanol, propanol, butanol, pentanol and hexanol. The study provides an insight in the binary and ternary microemulsion systems of the nonionic surfactant, which can be further employed to examine the structure of various alcohol-rich alcohol/water mixtures.

Published
2007

49. Inequities in access to biologic and synthetic DMARDs across 46 European countries

Author

Putrik, Polina, Ramiro, Sofia, Kvien, Tore K, Sokka, Tuulikki, Pavlova, Milena, Uhlig, Till, Boonen, Annelies, Tafaj, Argjent, Harutyunyan, Ruzanna, Radner, Helga, Soroka, Nikolay, Mielants, Herman, Sokolovic, Sekib, Lambova, Sevdalina, Mayer, Miroslav, Charalambous, Paraskevi, Vencovsky, Jiri, Hetland, Merete Lund, Peets, Tõnu, Fautrel, Bruno, Letsveridze, Khatuna, Müller-Ladner, Ulf, Sidiropoulos, Prodromos, Péntek, Márta, Gröndal, Gerdur, FitzGerald, Oliver, Bruno, Seriolo, Togizbayev, Galimzhan, Andersone, Daina, Butrimienė, Irena, Hirsch, Marco, Misevska-Percinkova, Snezana, Cassar, Karen, Deseatnicova, Elena, Mustur, Dusan, Głuszko, Piotr, Tavares, Viviana, Berghea, Florian, Shirinsky, Ivan, Veljkovic, Miodrag, Rovensky, Jozef, Tomsic, Matija, Sivera, Francisca, Petersson, Ingemar F., Axel, Finckh, Shaydullo, Sharipov, Inanc, Nevsun, Dumenko, Tatyana, Verstappen, Suzanne, and Khudoberdiev, Hojimurad

Published
2014
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