1. The effect of specimen processing time on HER2 expression in gastric cancer and esophagogastric junction cancer: a single-center retrospective observational study
- Author
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Yoshitomo Yanagimoto, Hiroshi Imamura, Shiro Adachi, Kazuki Odagiri, Tomono Kawase, Masafumi Yamashita, Hiroshi Takeyama, Yozo Suzuki, Masakazu Ikenaga, Junzo Shimizu, Naohiro Tomita, and Keizo Dono
- Subjects
HER2 expression ,Gastric cancer ,Esophagogastric junction cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Recent developments in the field of companion diagnosis and molecular-targeting therapeutic agents have helped in developing treatments targeting human epidermal growth factor receptor 2 (HER2) in gastric cancer (GC) and esophagogastric junction cancer (EGJC), and the importance of accurate diagnosis of HER2 expression is increasing. However, the HER2-positivity rate significantly differs among reports in GC and EGJC, and factors that affect HER2-positivity require elucidation. Methods The present study retrospectively examined factors related to HER2-positivity in a single institution, including age, sex, body mass index, the American Society of Anesthesiologists physical status, tumor information, and surgery information, including time to specimen processing. Results Our study included 165 patients tested for HER2 using GC and EGJC surgery specimens among the 1,320 patients who underwent gastrectomy from January 2007 to June 2022. In total, 35 (21.2%) and 130 (78.8%) patients were HER2-positive and -negative, respectively. Multivariate analysis revealed that intestinal type (odds ratio [OR]: 3.41, 95% confidence interval [CI]: 1.44–8.09, p = 0.005), pM1 (OR: 3.99, 95% CI: 1.51–10.55, p = 0.005), and time to specimen processing of
- Published
- 2023
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