491 results on '"Tomohiro YAMADA"'
Search Results
2. Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients
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Naoki Segi, Hiroaki Nakashima, Sadayuki Ito, Jun Ouchida, Noriaki Yokogawa, Takeshi Sasagawa, Toru Funayama, Fumihiko Eto, Kota Watanabe, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Yoshinori Terashima, Ryosuke Hirota, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Kenichi Kawaguchi, Yohei Haruta, Ko Hashimoto, Yoshito Onoda, Kazuo Nakanishi, Kosuke Misaki, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Hiroshi Uei, Hirokatsu Sawada, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Nobuyuki Suzuki, Kenji Kato, Koji Akeda, Norihiko Takegami, Yoichi Iizuka, Yasushi Oshima, Hitoshi Tonomura, Katsuhito Kiyasu, Haruki Funao, Toshitaka Yoshii, Masayuki Ishihara, Takashi Kaito, Shoji Seki, Kenichiro Kakutani, Hiroyuki Tominaga, Tetsuro Ohba, Daisuke Sakai, Bungo Otsuki, Masashi Miyazaki, Seiji Okada, Shiro Imagama, and Satoshi Kato
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dysphagia ,cervical spinal cord injury ,elderly patients ,geriatric nutritional risk index ,frailty index ,Surgery ,RD1-811 - Abstract
Introduction: For older adults, dysphagia is a serious problem that can occur after spinal cord injury (SCI), but its risk factors are unclear. This study aimed to identify risk factors for dysphagia in elderly patients (65 years) with cervical SCI. Methods: This multicenter study included 707 patients with cervical SCI (mean age 75.3 years). Univariate and multivariate analyses were conducted for patient characteristics and geriatric nutritional risk index (GNRI). Results: Dysphagia occurred in 69 patients (9.8%). The significant factors were as follows: male sex (odds ratio [OR] 3.43), GNRI
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- 2024
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3. Efficacy and safety of molecularly targeted agents and immune checkpoint inhibitors for unresectable or recurrent/metastatic oral cancer in Japan
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Mitsunobu Otsuru, Nobuhiro Yamakawa, Tadaaki Kirita, Shin-ichi Yamada, Hiroshi Kurita, Takuma Kugimoto, Hiroyuki Harada, Takumi Hasegawa, Masaya Akashi, Akinori Takeshita, Narikazu Uzawa, Masahiro Umeda, Souichi Yanamoto, and Tomohiro Yamada
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Oral cancer ,Immune checkpoint inhibitors (ICIs) ,Progression-free survival (PFS) ,PFS 2 (PFS2) ,Japan ,Dentistry ,RK1-715 - Abstract
Background/purpose: For unresectable recurrent/metastatic head and neck cancer, pembrolizumab alone or pembrolizumab combined with cisplatin and 5-fluorouracil is the first-line therapy, depending on the PD-L1 combined positive score (CPS). However, this is based on clinical studies of head and neck cancer, and few similar studies have been conducted on oral cancer alone. This study aimed to investigate the current status of pharmacotherapy for unresectable, recurrent, or metastatic oral cancer. Materials and methods: Patients with unresectable or recurrent/metastatic oral cancer who received cetuximab, nivolumab, or pembrolizumab as first-line treatment were reviewed. Overall survival (OS), progression-free survival (PFS), PFS 2 (PFS2), overall response rate (ORR), disease control rate (DCR), and immune-related adverse events were obtained from medical records. Results: A total of 155 patients were enrolled from six hospitals. The ORR in the nivolumab, pembrolizumab, and cetuximab groups was 17.2 %, 4.2 %, and 21.6 %, respectively, and the DCR was 37.9 %, 41.7 %, and 58.8 %, respectively. Median OS in nivolumab, pembrolizumab, and cetuximab groups was 10.3, 9.5, and 11.1 months, respectively. No significant differences were observed in survival among the three groups. The small number of cases and the retrospective nature of the study precluded the determination of the more effective first-line treatment among the three drugs. Conclusion: The current statuses of nivolumab, pembrolizumab, and cetuximab in unresectable recurrent metastatic oral cancer was reported.
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- 2024
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4. Implications of the diagnosis of locomotive syndrome stage 3 for long-term care
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Koichiro Ide, Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Mitsuru Hanada, Tomohiro Banno, Hideyuki Arima, Shin Oe, Tomohiro Yamada, Yuh Watanabe, Kenta Kurosu, Hironobu Hoshino, Haruo Niwa, Daisuke Togawa, and Yukihiro Matsuyama
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Locomotive syndrome ,Long-term care ,Motor function ,Musculoskeletal ,Nursing care ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Objectives: Locomotive syndrome stage 3 (LS3), which has been established recently, may imply a greater need for care than LS stage 0 (LS0), LS stage 1 (LS1), and LS stage 2 (LS2). The relationship between LS3 and long-term care in Japan is unclear. Therefore, this study aimed to examine this relationship. Methods: A total of 531 patients (314 women and 217 men; mean age, 75 years) who were not classified as requiring long-term care and underwent musculoskeletal examinations in 2012 were grouped according to their LS stage. Group L comprised patients with LS3 and Group N comprised those with LS0, LS1, and LS2. We compared these groups according to their epidemiology results and long-term care requirements from 2013 to 2018. Results: Fifty-nine patients (11.1%) were diagnosed with LS3. Group L comprised more patients (50.8%) who required long-term care than Group N (17.8%) (P
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- 2024
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5. Acid-Catalyzed Solvolysis of Softwood in Caprylyl Glycol to Produce Lignin Derivatives
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Tomohiro Yamada, Yuki Tobimatsu, Thi Thi Nge, Yusuke Matsumoto, and Tatsuhiko Yamada
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Chemistry ,QD1-999 - Published
- 2024
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6. Reshrinkage of Giant-Cell Tumor of the Bone in the Thoracic Vertebrae after Resumption of Denosumab Treatment: A Case Report
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Keika Nishi, Tomohiko Hasegawa, Yu Yamato, Go Yoshida, Tomohiro Banno, Hideyuki Arima, Shin Oe, Yuh Watanabe, Koichiro Ide, Tomohiro Yamada, Kenta Kurosu, and Yukihiro Matsuyama
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giant-cell tumor of the bone ,denosumab ,vertebral tumor ,ct-guided needle biopsy ,Surgery ,RD1-811 - Published
- 2024
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7. Cost-Effectiveness of Corrective Fusion Surgeries for Adult Spinal Deformities: Does Unexpected Revision Surgery Affect Cost-Effectiveness?
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Hideyuki Arima, Tomohiko Hasegawa, Yu Yamato, Masashi Kato, Go Yoshida, Tomohiro Banno, Shin Oe, Koichiro Ide, Tomohiro Yamada, Keiichi Nakai, Kenta Kurosu, and Yukihiro Matsuyama
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adult spinal deformity ,cost-effectiveness ,quality-adjusted life year ,corrective fusion surgery ,medical expenses ,spinal instrumentation ,revision surgery ,rod fractures ,Surgery ,RD1-811 - Abstract
Introduction: Previous research has demonstrated that mid- to long-term health-related quality of life following corrective fusion surgery for adult spinal deformity (ASD) can be improved by appropriate revision surgery. In this study, we aim to compare the cost-effectiveness of corrective fusion surgery for ASD with and without unexpected revision surgery 5 years postoperatively. Methods: In total, 79 patients with ASD (mean age, 68.7 years) who underwent corrective fusion surgery between 2013 and 2015 were included in this study. Cost-effectiveness was evaluated based on the cost of obtaining 1 quality-adjusted life year (QALY). Patients were divided into two groups according to the presence or absence of unexpected revision surgery following corrective fusion and were subjected for comparison. Results: As per our study findings, 26 (33%) of the 79 ASD patients underwent unexpected revision surgery during the first 5 years following surgery. Although there was no significant difference in terms of inpatient medical costs at the time of initial surgery for 5 years after surgery between the two groups (no-revision group, revision group; inpatient medical costs at the time of initial surgery: USD 69,854 vs. USD 72,685, P=0.344), the total medical expenses up to 5 years after surgery were found to be higher in the revision group (USD 72,704 vs. USD 104,287, P
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- 2024
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8. Comparative analysis of changes in spinal dimensions following different correction methods in adult spinal deformity surgery
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Hoai TP Dinh, Hiroki Ushirozako, Tomohiko Hasegawa, Yu Yamato, Go Yoshida, Tomohiro Banno, Hideyuki Arima, Shin Oe, Tomohiro Yamada, Koichiro Ide, Kenta Kurosu, and Yukihiro Matsuyama
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Orthopedic surgery ,RD701-811 - Abstract
Background: Adult spinal deformity (ASD) surgery has gained popularity, with significant improvements in patient-reported outcomes. Posterior lumbar interbody fusion with multiple grade II osteotomies (PLIF + MOs) and lateral lumbar interbody fusion (LLIF) have been utilized to correct ASD; however, no studies have compared these methods with regard to the pre- and postoperative changes in length and volume of the spinal canal. This study aimed to investigate the 3-dimensional changes in the anterior vertical column length (AVCL), spinal canal length (SCL), and spinal canal volume (SCV) in patients with ASD after surgery, employing LLIF and PLIF + MOs. Methods: This retrospective study examined 44 patients with ASD who underwent surgery between 2010 and 2021 using two corrective surgical methods, LLIF and PLIF + MOs. Radiographic parameters and clinical outcomes were assessed, and three-dimensional models were created from computed tomography images to analyze changes in AVCL, SCL, and SCV. Results: We compared the effects of LLIF and PLIF + MOs on spinal canal dimensions during ASD surgery. LLIF demonstrated an increase in lumbar segment (L1-S1) AVCL and whole spine (T1-S1) SCL by 6.5 ± 8.0 mm and 13.8 ± 7.6 mm, respectively, compared with PLIF + MOs. However, PLIF + MOs exhibited a reduction in the lengths of the lumbar segment AVCL. Postoperative differences were significant for AVCL (L1-S1), SCL fusion level, and first-standing lumbar lordosis between the groups ( p < 0.0001, 0.002, and 0.016, respectively). LLIF significantly increased the SCV at the fusion level and whole spine T1-S1 by 14.5% and 10.6%, respectively, outperforming PLIF + MOs. Despite changes in dimensions, the postoperative Oswestry disability index scores showed no significant difference between the two groups. Conclusions: Our study suggests that LLIF can increase spinal canal space, lumbar lordosis, and anterior column length in the lumbar spinal segment. Knowledge of these variations may be critical for enhancing surgical outcomes and preventing neurological complications.
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- 2024
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9. Psychological Factors Can Affect the Clinical Outcome of Chemonucleolysis with Condoliase in Patients with Lumbar Disk Herniation
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Tomohiro Banno, Tomohiko Hasegawa, Yu Yamato, Go Yoshida, Hideyuki Arima, Shin Oe, Koichiro Ide, Tomohiro Yamada, Kenta Kurosu, and Yukihiro Matsuyama
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chemonucleolysis ,condoliase therapy ,lumbar disk herniation ,psychological factors ,Surgery ,RD1-811 - Abstract
Introduction: Condoliase-based chemonucleolysis is a minimally invasive intermediate treatment option between conservative approaches and surgical interventions for lumbar disk herniation (LDH). In this study, the effects of psychological factors on the clinical outcomes of condoliase therapy for LDH were assessed. Methods: This study involved patients with LDH who received condoliase injections over a 1-year follow-up period. Data from the visual analog scale (VAS) scores for leg and back pain, Oswestry Disability Index, and Hospital Anxiety and Depression Scale (HADS), which was utilized for the psychological assessment, were collected. Using magnetic resonance imaging, changes in disk height and degeneration were evaluated. Data were assessed at baseline and 1-month, 3-month, and 1-year follow-ups. Condoliase therapy was considered effective in patients whose VAS score for leg pain improved by 50% at 1 year from baseline and who did not require surgery. The patients were divided into two groups: those who reported effective treatment (Group E) and those who did not (Group I). Between these two groups, comparative analyses were carried out. Results: In this study, a total of 102 patients (70 men; mean age, 43.8±18.2 years) were included. Condoliase therapy was effective in 76 patients (74.5%). Thirty-five patients (34.3%) showed psychological factors (HADS-Anxiety [HADS-A]8 or HADS-Depression [HADS-D]8) preoperatively and had a significantly lower rate of effectiveness than did those without psychological factors. Group I demonstrated significantly higher baseline back pain VAS, HADS, and HADS-D scores when compared with Group E. Logistic regression analysis identified females and the baseline HADS-D score as independent factors that were related to the effectiveness of condoliase therapy. Conclusions: The patients with psychological factors tended to experience residual pain resulting in adverse effects on the clinical outcomes of chemonucleolysis with condoliase.
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- 2024
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10. Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury
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Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Junichi Yamane, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, and Satoshi Kato
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Medicine ,Science - Abstract
Abstract This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1 months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1 year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity. In the Kaplan–Meier analysis, the median survival times were 44.9 and 76.5 months for patients with major nutrition-related risk and matched controls, respectively (p = 0.015). Matched controls had more individuals with a neurological improvement of American Spinal Injury Association Impairment Scale ≥ 1 grade (p = 0.039) and independence in ADL at 1 year post-injury than patients with major nutrition-related risk (p
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- 2024
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11. Development of the Complement C5 Assay by LC–MS/MS in Monkey Serum and Comparison with Enzyme-Linked Immunosorbent Assay
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Kiyomi Kikuchi, Yoko Ida, Tomohiro Yamada, and Yuji Mano
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Chemistry ,QD1-999 - Published
- 2024
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12. Spindle cell lipoma of the floor of mouth
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Yuta Yanai, DDS, PhD, Yasutaka Kubota, DDS, PhD, Tomoko Kitsuki, DDS, PhD, Risa Yanai, DDS, PhD, and Tomohiro Yamada, DDS, PhD
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Spindle cell lipoma ,Oral cavity ,Floor of mouth ,Adipocytic tumor ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
The patient was a man in his 60s with the gradually increasing mass in his mouth. A well-defined, elastic soft mass with a major diameter of 60 mm was found on the right floor of mouth. The magnetic resonance imaging findings showed a well-defined mass with high signal on both T1 and T2-weighted image in the right sublingual space. The mass was slightly heterogeneous inside and had a septum-like appearance. The tumor was resected with care not to damage the capsule. Histopathological findings showed mature adipocytes, spindle-shaped cells, and collagenous components. Spindle cells were CD34-positive. The tumor was diagnosed as spindle cell lipoma. The patient was followed up for 6 months with no recurrence. Spindle cell lipoma is a rare entity and this is the largest case in the oral cavity. Because there are wide variety of adipocytic tumors, the careful examination of their imaging and histopathological findings is essential.
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- 2023
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13. Acid-Catalyzed Solvolysis of Softwood Using Polyethylene Glycol Monomethyl Ether to Produce Functional Lignin Derivatives
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Tomohiro Yamada, Yusuke Matsumoto, Thi Thi Nge, and Tatsuhiko Yamada
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glycol lignin ,acid-catalyzed solvolysis ,polyethylene glycol monomethyl ether ,softwood ,Biotechnology ,TP248.13-248.65 - Abstract
Glycol lignins (GLs) produced through acid-catalyzed solvolysis of softwood meal using glycols, such as polyethylene glycol (PEG), have been used for the development of functional materials. In this study, GLs with various physical and chemical properties were synthesized via solvolysis with monomethyl ethers of polyethylene glycol (MPEG), such as MPEG-n4 and MPEG-n8. The effects of the reaction time and temperature on the yield, molecular weight, and thermal properties of MPEG-lignin were studied. The yield of MPEG-lignin increased with the solvolysis time. Acid-catalyzed solvolysis using MPEG-n4 occurred faster than that using MPEG-n8. Higher reaction temperature resulted in a higher yield of MPEG-lignin with a higher glass transition temperature (Tg) and viscous thermal flow temperature (Tf). The Tg and Tf of MPEG-lignins increased with the solvolysis time. The MPEG-lignins synthesized at higher reaction temperatures showed a relatively strong carbonyl absorbance band in the infrared spectra, which was ascribed to decomposed sugar derivatives.
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- 2023
14. Change in Line of Sight after Corrective Surgery of Adult Spinal Deformity Patients: A 2-Year Follow-up
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Ken Jeffrey Magcalas, Shin Oe, Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Tomohiro Banno, Hideyuki Arima, Yuki Mihara, Hiroki Ushirozako, Tomohiro Yamada, Koichiro Ide, Yuh Watanabe, and Yukihiro Matsuyama
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line of sight ,adult spinal deformity ,slope of mcgregor’s line ,horizontal gaze ,cranial parameters ,Medicine - Abstract
Study Design Cohort study. Purpose There is currently no published study that focuses on the spinal corrective surgery effects with cranial parameters in adult spinal deformity (ASD) patients. It is an important factor to measure since it plays a critical role in maintaining the line of sight. The objective is to determine the change in cranial parameters using the slope of McGregor’s line (McGS) after ASD surgery after 2 years of follow-up. Overview of Literature A study concluded that cervical spine alignment (C2–C7 lordosis) is strongly affected by thoracic kyphosis (TK). Another study showed that patients with ascending gaze had significantly more thoracolumbar malalignment. Methods This retrospective study includes 295 corrective surgery patients with ASD. Subjects were divided into two groups after propensity age matching analysis: cranial malalignment (McGS 13) and normal cranial alignment (−8≤ McGS ≤13). Lumbar lordosis (LL), pelvic tilt (PT), TK, cervical lordosis (CL), and sagittal vertical axis (SVA) were evaluated between the two groups. Results SVA (95–56 mm) and PT (34°–25°) decreased and LL (19°–41°) increased 2 years after surgery (p
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- 2023
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15. Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament
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Shun Okuwaki, Toru Funayama, Masao Koda, Fumihiko Eto, Akihiro Yamaji, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, and Satoshi Kato
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Medicine ,Science - Abstract
Abstract Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown. We identified OPLL characteristics and determined whether they influence neurological severity and improvement of CSCI in older patients. This multicenter retrospective cohort study identified 1512 patients aged ≥ 65 years diagnosed with CSCI on admission during 2010–2020. We analyzed CSCI etiology in OPLL patients. We performed propensity score-adjusted analyses to compare neurological outcomes between patients with and without OPLL. Cases were matched based on variables influencing neurological prognosis. The primary neurological outcome was rated according to the American Spine Injury Association (ASIA) impairment scale (AIS) and ASIA motor score (AMS). In 332 OPLL patients, the male-to-female ratio was approximately 4:1. Half of all patients displayed low-energy trauma-induced injury and one-third had CSCI without a bony injury. Propensity score matching created 279 pairs. There was no significant difference in the AIS grade and AMS between patients with and without OPLL during hospitalization, 6 months, and 12 months following injury. OPLL patients tended to exhibit worse neurological findings during injury; nevertheless, OPLL was not associated with poor neurological improvement in older CSCI patients.
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- 2023
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16. Revision Surgery for a Rod Fracture with Multirod Constructs Using a Posterior-Only Approach Following Surgery for Adult Spinal Deformity
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Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Tomohiro Banno, Shin Oe, Hideyuki Arima, Yuki Mihara, Hiroki Ushirozako, Tomohiro Yamada, Yuh Watanabe, Koichiro Ide, Keiichi Nakai, Kenta Kurosu, and Yukihiro Matsuyama
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rod fracture ,adult spinal deformity ,multirod constructs ,implant-related complications ,reoperation ,Medicine - Abstract
Study Design Single-center retrospective case series. Purpose We aimed to evaluate the clinical results of revision surgery for a rod fracture using a posterior-only approach and determine the best procedure to prevent refracture in patients with adult spinal deformity (ASD). Overview of Literature ASD affects the thoracolumbar spine and often requires surgical correction. However, surgery for extensive spinal fusion causes rod fracture, a major mechanical complication. Few studies have described the treatment methods for rod fractures. Furthermore, the clinical outcomes of revision surgery for rod fractures in patients with ASD are currently unclear. Methods We retrospectively reviewed the medical records of 404 patients who underwent corrective fusion surgery for ASD with a minimum 2-year follow-up. We studied cases of reoperation for postoperative rod fractures and investigated surgical procedure, intraoperative findings, clinical course, and rod refracture following revision surgery. Results Rod fracture was observed in 88 patients (21.8%). Fifty-three patients (average age, 68.3 years; average blood loss, 502.2 mL [% estimated blood volume=16.4%]; and operation time, 203.3 minutes) who suffered from a rod fracture at an average of 28.3 months after the primary operation underwent reoperation. Surgical invasiveness had no significant differences in total or partial rod replacement; however, the procedures with and without an anterior bone graft significantly differed. The replaced rod refractured at an average of 35.3 months after the revision surgery of five patients. The rod also refractured at a level outside multiple rods in two patients and with traumatic episodes in three patients. Three patients had bone grafts in the anterior column. Conclusions Revision surgery involving a multirod with a posterior-only approach for a rod fracture that occurred after ASD was performed successfully. Bone grafting in the anterior column is unnecessary for patients without massive bone defects.
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- 2022
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17. Differences in clinical characteristics of cervical spine injuries in older adults by external causes: a multicenter study of 1512 cases
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Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Hayashi, Hiroyuki Tsuchiya, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Satoshi Nori, Junichi Yamane, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, and Kota Watanabe
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Medicine ,Science - Abstract
Abstract Although traumatic cervical spine injuries in older adults are commonly caused by minor traumas, such as ground-level falls, their prognosis is often unfavorable. Studies examining the clinical characteristics of cervical spine injuries in older adults according to the external cause of injury are lacking. This study included 1512 patients of ≥ 65 years of age with traumatic cervical spine injuries registered in a Japanese nationwide multicenter database. The relationship between the external causes and clinical characteristics, as well as factors causing unfavorable outcomes at the ground-level falls, were retrospectively reviewed and examined. When fall-induced cervical spine injuries were categorized and compared based on fall height, the patients’ backgrounds and injury statuses differed significantly. Of note, patients injured from ground-level falls tended to have poorer pre-injury health conditions, such as medical comorbidities and frailty, compared with those who fell from higher heights. For ground-level falls, the mortality, walking independence, and home-discharge rates at 6 months post-injury were 9%, 67%, and 80%, respectively, with preexisting medical comorbidities and frailty associated with unfavorable outcomes, independent of age or severity of neurological impairment at the time of injury.
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- 2022
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18. A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients
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Takeshi Sasagawa, Noriaki Yokogawa, Hiroyuki Hayashi, Hiroyuki Tsuchiya, Kei Ando, Hiroaki Nakashima, Naoki Segi, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Ko Hashimoto, Yoshito Onoda, Kenichiro Kakutani, Yuji Kakiuchi, Nobuyuki Suzuki, Kenji Kato, Yoshinori Terashima, Ryosuke Hirota, Tomohiro Yamada, Tomohiko Hasegawa, Kenichi Kawaguchi, Yohei Haruta, Shoji Seki, Hitoshi Tonomura, Munehiro Sakata, Hiroshi Uei, Hirokatsu Sawada, Hiroyuki Tominaga, Hiroto Tokumoto, Takashi Kaito, Yoichi Iizuka, Eiji Takasawa, Yasushi Oshima, Hidetomi Terai, Koji Tamai, Bungo Otsuki, Masashi Miyazaki, Hideaki Nakajima, Kazuo Nakanishi, Kosuke Misaki, Gen Inoue, Katsuhito Kiyasu, Koji Akeda, Norihiko Takegami, Toshitaka Yoshii, Masayuki Ishihara, Seiji Okada, Yasuchika Aoki, Katsumi Harimaya, Hideki Murakami, Ken Ishii, Seiji Ohtori, Shiro Imagama, and Satoshi Kato
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Cervical fracture ,Spinal fusion surgery ,Elderly ,Mortality ,Walking capacity ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background The 1-year mortality and functional prognoses of patients who received surgery for cervical trauma in the elderly remains unclear. The aim of this study is to investigate the rates of, and factors associated with mortality and the deterioration in walking capacity occurring 1 year after spinal fusion surgery for cervical fractures in patients 65 years of age or older. Methods Three hundred thirteen patients aged 65 years or more with a traumatic cervical fracture who received spinal fusion surgery were enrolled. The patients were divided into a survival group and a mortality group, or a maintained walking capacity group and a deteriorated walking capacity group. We compared patients’ backgrounds, trauma, and surgical parameters between the two groups. To identify factors associated with mortality or a deteriorated walking capacity 1 year postoperatively, a multivariate logistic regression analysis was conducted. Results One year postoperatively, the rate of mortality was 8%. A higher Charlson comorbidity index (CCI) score, a more severe the American Spinal Cord Injury Association impairment scale (AIS), and longer surgical time were identified as independent factors associated with an increase in 1-year mortality. The rate of deterioration in walking capacity between pre-trauma and 1 year postoperatively was 33%. A more severe AIS, lower albumin (Alb) and hemoglobin (Hb) values, and a larger number of fused segments were identified as independent factors associated with the increased risk of deteriorated walking capacity 1 year postoperatively. Conclusions The 1-year rate of mortality after spinal fusion surgery for cervical fracture in patients 65 years of age or older was 8%, and its associated factors were a higher CCI score, a more severe AIS, and a longer surgical time. The rate of deterioration in walking capacity was 33%, and its associated factors were a more severe AIS, lower Alb, lower Hb values, and a larger number of fused segments.
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- 2022
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19. Is Blood Loss Greater in Elderly Patients under Antiplatelet or Anticoagulant Medication for Cervical Spine Injury Surgery? A Japanese Multicenter Survey
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Masashi Uehara, Shota Ikegami, Takashi Takizawa, Hiroki Oba, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Sumihisa Orita, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Yasuchika Aoki, Katsumi Harimaya, Hideki Murakami, Ken Ishii, Seiji Ohtori, Shiro Imagama, and Satoshi Kato
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cervical spine injury ,elderly patients ,blood loss volume ,comorbidity ,antiplatelet/anticoagulant drugs ,Surgery ,RD1-811 - Abstract
Introduction: In elderly patients with cervical spinal cord injury, comorbidities such as cardiovascular and cerebrovascular diseases are common, with frequent administration of antiplatelet/anticoagulant (APAC) drugs. Such patients may bleed easily or unexpectedly during surgery despite prior withdrawal of APAC medication. Few reports have examined the precise relationship between intraoperative blood loss and history of APAC use regarding surgery for cervical spine injury in the elderly. The present multicenter database survey aimed to answer the question of whether the use of APAC drugs affected the amount of intraoperative blood loss in elderly patients with cervical spinal cord trauma. Methods: The case histories of 1512 patients with cervical spine injury at 33 institutes were retrospectively reviewed. After excluding cases without spinal surgery or known blood loss volume, 797 patients were enrolled. Blood volume loss was the outcome of interest. We calculated propensity scores using the inverse probability of treatment weighting (IPTW) method. As an alternative sensitivity analysis, linear mixed model analyses were conducted as well. Results: Of the 776 patients (mean age: 75.1±6.4 years) eligible for IPTW calculation, 157 (20.2%) were taking APAC medications before the injury. After weighting, mean estimated blood loss was 204 mL for non-APAC patients and 215 mL for APAC patients. APAC use in elderly patients was not significantly associated with surgical blood loss according to the IPTW method with propensity scoring or linear mixed model analyses. Thus, it appeared possible to perform surgery expecting comparable blood loss in APAC and non-APAC cases. Conclusions: This multicenter study revealed no significant increase in surgical blood loss in elderly patients with cervical trauma taking APAC drugs. Surgeons may be able to prioritize patient background, complications, and preexisting conditions over APAC use before injury when examining the surgical indications for cervical spine trauma in the elderly.
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- 2022
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20. Selective Angiography to Detect Anterior Spinal Artery Stenosis in Thoracic Ossification of the Posterior Longitudinal Ligament
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Go Yoshida, Hiroki Ushirozako, Tomohiko Hasegawa, Yu Yamato, Tatsuya Yasuda, Tomohiro Banno, Hideyuki Arima, Shin Oe, Yuki Mihara, Tomohiro Yamada, Koichiro Ide, Yuh Watanabe, Takasuke Ushio, and Yukihiro Matsuyama
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anterior spinal artery ,adamkiewicz artery ,ossification of the posterior longitudinal ligament ,angiography ,doppler ultrasonography ,Medicine - Abstract
Study Design Single-center prospective study. Purpose To investigate anterior spinal artery (ASA) status using preoperative selective angiography in patients undergoing surgery for thoracic ossification of the posterior longitudinal ligament (T-OPLL). Overview of Literature Surgery for T-OPLL has a high risk of neurological complications, which might be associated with insufficient spinal cord blood flow. Methods This study prospectively examined nine T-OPLL patients who underwent posterior thoracic decompression with kyphosis correction and instrumented fusion at Hamamatsu University School of Medicine between 2017 and 2019. All underwent preoperative selective angiography to detect and evaluate the Adamkiewicz artery and ASA. Intraoperative neuromonitoring and Doppler ultrasonography were performed to analyze neurological complications and spinal cord blood flow. Results All nine patients showed ASA stenosis in the area of T-OPLL. In all patients, the Adamkiewicz artery was located between T7 and L2 and the area of ASA stenosis corresponded to the level of T-OPLL and greatest spinal cord compression; intraoperative Doppler ultrasonography confirmed the ASA defect at the same spinal level. The number of spinal levels from the Adamkiewicz artery to the most compressive OPLL lesion was greater in the two patients who developed postoperative neurological deficit compared to those who did not (5.5 vs. 2.3, p=0.014). Conclusions This is the first study to report detection of ASA stenosis in patients with T-OPLL. Maintaining spinal cord blood flow is important in these patients to avoid neurological deterioration.
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- 2022
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21. Why does knee flexion in the standing position occur? Spinal deformity or knee osteoarthritis
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Jili Wang, Hiroki Ushirozako, Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Tomohiro Banno, Hideyuki Arima, Shin Oe, Tomohiro Yamada, Koichiro Ide, Keiichi Nakai, Kenta Kurosu, Hironobu Hoshino, and Yukihiro Matsuyama
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Orthopedic surgery ,RD701-811 - Abstract
Background: The interaction between knee osteoarthritis and spinal deformity and knee flexion (KF) remains unclear. We aimed to clarify the relationship between KF in the standing position and the severity of spinal deformity and knee osteoarthritis. Methods: We analyzed older volunteers aged over 60 years who participated in the musculoskeletal screening program. The participant’s characteristics and standing radiographic parameters were assessed. After a preliminary analysis, a propensity score-matched model was established with adjustments for age, sex, and body mass index (BMI). Cases were divided into KF (knee angle [KA] ≥10°) and non-KF (KA
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- 2023
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22. Association between Pelvic Parameters and Vaginal Delivery
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Tomohiro Yamada, Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Tatsuya Yasuda, Tomohiro Banno, Hideyuki Arima, Shin Oe, Yuki Mihara, Hiroki Ushirozako, Koichiro Ide, Yuh Watanabe, Hironobu Hosino, and Yukihiro Matsuyama
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vaginal delivery ,cesarean section ,pelvic incidence ,Medicine - Abstract
Study Design Cross-sectional study. Purpose To investigate the association between vaginal delivery and pelvic parameters and clarify the effect of parity on parameter fluctuations. Overview of Literature During vaginal delivery, the sacroiliac joint widens and the sacrum nutates (nods). However, the association between these pelvic parameters and parity is unknown. Methods As part of a 2016 health screening, 320 female volunteers underwent whole-spine radiographs. Age-matched healthy women were grouped according to the number of vaginal deliveries (0, 1–2, or ≥3). Demographic variables and spinopelvic parameters were compared among the three groups. Results Of the 320 volunteers, 213 were enrolled (mean age, 71.1±7.2 years). The mean number of vaginal deliveries was 2.2. The average pelvic incidence (PI) was 55.6°±11.1° and was significantly higher in the 90 women with three or more vaginal deliveries than in the other two groups (p
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- 2022
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23. Incidence and Predictors of Postoperative Kyphotic Deformity after Thoracic Spinal Cord Tumor Resection
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Hideyuki Arima, Tomohiko Hasegawa, Yu Yamato, Go Yoshida, Tomohiro Banno, Shin Oe, Yuki Mihara, Hiroki Ushirozako, Tomohiro Yamada, Koichiro Ide, Yuh Watanabe, Keiichi Nakai, Kenta Kurosu, and Yukihiro Matsuyama
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thoracic spine ,spinal cord tumor ,kyphosis ,laminectomy ,laminoplasty ,fixation ,Surgery ,RD1-811 - Abstract
Introduction: Kyphotic deformity is common after spinal tumor resection surgery. An adequate field of view is needed to resect the spinal cord tumor, and, in some cases, the facet joint must be removed during laminectomy, and fixation may be performed simultaneously. In this study, we investigated the incidence of postoperative deformity after spinal tumor resection and the factors associated with postoperative deformity. Methods: We retrospectively analyzed patients who underwent thoracic spinal cord tumor resection at a single institution between 2010 and 2017 and were followed up for at least 24 months after surgery. Fifty percent or more of the facet joint was removed during the laminectomy, and fixation was performed simultaneously. Patients were divided into two groups, with and without kyphotic deformity. Patient demographic characteristics (age at surgery and gender), whether they underwent primary surgery or reoperation, tumor level, pathological type, and surgical method were compared. Multiple linear regression analysis was performed to identify independent predictors of kyphotic deformity. Results: Thirty-one patients were found to be eligible. Thirteen patients had intramedullary spinal cord tumors. Laminectomy was performed in 52% (N=16), laminoplasty in 6% (N=2), and laminectomy and/or laminoplasty combined with fusion in 42% (N=13) of the patients. During a mean follow-up period of 66.8 months, 12 (39%) patients had postoperative kyphosis deformities, of which one patient (3%, a 12-year-old girl who underwent combined postoperative radiation therapy) underwent kyphosis correction surgery three years after surgery. The number of laminectomies was independently associated with kyphotic deformity. Conclusions: Although kyphotic deformity after spinal tumor surgery was observed in about 39% of the patients, corrective surgery was rarely required due to the progression of the deformity. The high number of laminectomies is a risk factor for postoperative kyphosis, and prophylactic fixation may be considered in cases of multiple laminectomies.
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- 2022
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24. Hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis is associated with abnormal accumulation of specific lipids
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Tomohiro Yamada, Makoto Horikawa, Tomohito Sato, Tomoaki Kahyo, Yusuke Takanashi, Hiroki Ushirozako, Kenta Kurosu, Md. Al Mamun, Yuki Mihara, Shin Oe, Hideyuki Arima, Tomohiro Banno, Go Yosida, Tomohiko Hasegawa, Yu Yamato, Yukihiro Matsuyama, and Mitsutoshi Setou
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Medicine ,Science - Abstract
Abstract Ligamentum flavum hypertrophy (HLF) is the most important component of lumbar spinal canal stenosis (LSCS). Analysis of hypertrophied ligamentum flavum (HLF) samples from patients with LSCS can be an important que. The current study analyzed the surgical samples of HLF samples in patients with LCSC using quantitative and qualitative high performance-liquid chromatography and mass spectrometry. We collected ligamentum flavum (LF) tissue from twelve patients with LSCS and from four patients with lumbar disk herniation (LDH). We defined LF from LSCS patients as HLF and that from LDH patients as non-hypertrophied ligamentum flavum (NHLF). Total lipids were extracted from the LF samples and evaluated for quantity and quality using liquid chromatography and mass spectrometry. The total lipid amount of the HLF group was 3.6 times higher than that of the NHLF group. Phosphatidylcholines (PCs), ceramides (Cers), O-acyl-ω-hydroxy fatty acids (OAHFAs), and triglycerides (TGs) in the HLF group were more than 32 times higher than those of the NHLF group. PC(26:0)+H+, PC(25:0)+H+, and PC(23:0)+H+ increased in all patients in the HLF group compared to the NHLF group. The thickness of the LF correlated significantly with PC(26:0)+H+ in HLF. We identified the enriched specific PCs, Cers, OAHFAs, and TGs in HLF.
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- 2021
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25. Impact of Spinal Correction Surgeries with Osteotomy and Pelvic Fixation in Patients with Kyphosis Due to Osteoporotic Vertebral Fractures
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Tomohiko Hasegawa, Hiroki Ushirozako, Yu Yamato, Go Yoshida, Tatsuya Yasuda, Tomohiro Banno, Hideyuki Arima, Shin Oe, Tomohiro Yamada, Koichiro Ide, Yuh Watanabe, and Yukihiro Matsuyama
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vertebral fracture ,kyphosis ,distal junctional kyphosis ,osteotomy ,surgery ,Medicine - Abstract
Study Design Combination of retrospective and prospective study. Purpose We aimed to compare the clinical outcomes between local fixation surgery and spinopelvic fixation surgery for the treatment of kyphosis secondary to osteoporotic vertebral fractures with spinopelvic malalignment. Overview of Literature The clinical characteristics of patients with rigid kyphosis due to osteoporotic vertebral fracture differ from that of middle-aged patients with vertebral fractures in terms of bone fragility and presence of spinopelvic malalignment. Little is known about the surgical strategies for these deformities, most especially the extent of fusion of vertebra involved. Methods We analyzed 24 patients with vertebral osteotomy at the level of the fracture and spinal fixation without pelvic fixation (local group), and 22 patients with vertebral osteotomy and pelvic fixation (pelvic group). Radiographic parameters, the incidence of proximal junctional kyphosis (PJK), distal junctional kyphosis (DJK), rod fractures, and the Oswestry Disability Index (ODI) were compared between the two groups over a 2-year follow-up period. Results In the pelvic group, postoperative spinopelvic parameters significantly improved, with the improvements maintained. No remarkable changes in spinopelvic parameters were seen in the local group. The mean ODI scores 2 years after surgery were 45.3 and 33.0 in the local and pelvic group, respectively (p-value
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- 2021
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26. Combination therapy with preoperative embolization and en block laminectomy using thread saw for spinous process solitary fibrous tumor: A case report
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Tomohiro Yamada, MD, Tomohiko Hasegawa, MD, PhD, Yoji Shido, MD, PhD, Yu Yamato, MD, PhD, Go Yoshida, MD, PhD, Tatsuya Yasuda, MD, PhD, Tomohiro Banno, MD, PhD, Hideyuki Arima, MD, PhD, Shin Oe, MD, PhD, Hiroki Ushirozako, MD, PhD, Koichiro Ide, MD, Yuh Wanatabe, MD, and Yukihiro Matsuyama, MD, PhD
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Solitary fibrous tumor ,Preoperative embolization ,en bloc laminectomy ,Thread saw ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Solitary fibrous tumors are rare mesenchymal neoplasms with highly recurrence rates after intratumor resection. We report 2 cases of solitary fibrous tumors treated with combination therapy with embolization and en bloc laminectomy using thread saw. To the best of our knowledge, this is the first such report. In the 2 cases, the hypervascular tumors were located in the spinal process and infiltrating the multifidus. Preoperative embolization was useful for decreasing intraoperative bleeding, and using thread saw was an ideal technique for deciding the cut surface height of the pedicle to achieve gross total resection.
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- 2020
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27. Masticatory muscle function affects the pathological conditions of dentofacial deformities
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Tomohiro Yamada, Goro Sugiyama, and Yoshihide Mori
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Jaw deformity ,Muscle ,Myosin heavy chain ,Myokine ,Dentistry ,RK1-715 - Abstract
Summary: The causes of dentofacial deformities include various known syndromes, genetics, environmental and neuromuscular factors, trauma, and tumors. Above all, the functional effects of muscles are important, and deformation of the mandible is often associated with a mechanical imbalance of the masticatory muscles.With the vertical position of the face, weakness of the sling of the masseter muscle and medial pterygoid muscle causes dilatation of the mandibular angle. In patients with a deep bite, excessive function of the masticatory muscles is reported.Myosin heavy chain (MyHC) properties also affect jawbone morphology. In short-face patients, the proportion of type II fibers, which are fast muscles, is high. The proportions of muscle fiber types are genetically determined but can be altered by postnatal environmental factors. Orthognathic surgery may results in the transition of MyHC to type II (fast) fibers, but excessive stretching enhances the release of inflammatory mediators and causes a shift toward a greater proportion of slow muscle fibers. This feature can be related to postoperative relapse.Bones and muscles are in close crosstalk, and it may be possible to use biochemical approaches as well as biomechanical considerations for the treatment of jaw deformities.
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- 2020
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28. Influence of the Sagittal Vertical Axis on the Risk of Falls in Community-Dwelling Elderly People: A Retrospective Longitudinal Study
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Tomohiro Yamada, Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Tatsuya Yasuda, Tomohiro Banno, Hideyuki Arima, Shin Oe, Hiroki Ushirozako, Koichiro Ide, Yuh Watanabe, and Yukihiro Matsuyama
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falls ,elderly dwelling people ,sagittal vertical axis ,Surgery ,RD1-811 - Abstract
Introduction: Falling is an age-related problem that increases with age. Compared with younger people, elderly people possess increased risk factors for falls, and falling among the elderly is associated with increased mortality. Risk factors for falls have been reported in elderly outpatients; however, whether sagittal spinal posture affect the risk of falls in community residents remains unclear. Therefore, we aimed to investigate the influence of sagittal spinal posture on the risk of falls in elderly community-dwelling people using spino-plevic sagittal parameters in a retrospective longitudinal study. Methods: A total of 463 volunteers (96 men and 367 women; mean age, 72.8 years) who underwent a routine physical checkup were evaluated. Baseline whole spine and lower limb radiography, physical tests, bone mineral density (BMD), number of medications and comorbidities, patient-reported outcomes (PROs), and a history of falls in the previous four years period were examined. Results: Univariate analysis revealed older age, lower height and weight, higher prevalence of vertebral fractures, higher number of medications, poor physical test scores including one-leg standing test and prone trunk extension, poor PROs, a higher sagittal vertical axis, and higher pelvic tilt (PT) as factors significantly associated with the risk of falls, and multivariate analysis revealed a higher sagittal vertical axis [odds ratio (OR), 1.08; 95% confidence interval (CI), 1.002-1.013; P = 0.02] and locomotive syndrome assessed using the 25-Question Geriatric Locomotive Function Scale score (OR, 1.028; 95% CI, 1.004-1.053; P = 0.03) to be associated with the risk of falls, independent of other factors in the univariate analysis. Conclusions: The sagittal vertical axis was an independent risk factor for falls, and the prevalence of vertebral fractures and prone truck extension correlated with the sagittal vertical axis. Prospective and intervention studies are needed to prevent future falls in elderly community volunteers with a higher sagittal vertical axis.
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- 2020
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29. Spinal Sagittal Alignment, Hospital Anxiety and Depression Scale Scores, and Patient-Reported Outcome among People with Sporting Activity
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Shin Oe, Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Sho Kobayashi, Tatsuya Yasuda, Tomohiro Banno, Hideyuki Arima, Yuki Mihara, Hiroki Ushirozako, Tomohiro Yamada, Koichiro Ide, Yuh Watanabe, Haruo Niwa, and Yukihiro Matsuyama
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sporting activity ,patients reported outcome ,spinal sagittal alignment ,hospital anxiety and depression scale scores ,Medicine - Abstract
Study Design Retrospective cohort study. Purpose This study aimed to investigate how participation in sporting activity affects patient-reported outcome (PRO), including Neck Disability Index (NDI), in males and females. Overview of Literature Previously, our study reported that factors with a negative influence on the NDI in females were a lack of sporting activities. However, it was still unclear why it affected poor scores of NDI. Methods The subjects were 473 volunteers. They were divided into two groups (activity and non-activity) according to participation or non-participation in sporting activities using a self-filled questionnaire. The evaluation items were height, weight, grip strength, bone density, Hospital Anxiety and Depression Scale (HADS) score, standing radiographic parameters, PRO (evaluated by EuroQol-5 dimension [EQ-5D], Oswestry Disability Index [ODI]), and NDI. Results There were 101 males in the non-activity group and 69 in the activity group and 178 females in the non-activity group and 125 in the activity group. For the males, the evaluation items with significant influence were cervical lordosis (non-activity group:activity group, 17°:22°) and T1 slope minus cervical lordosis (10°:6°, p
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- 2020
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30. Observable Recurrence of Cervicothoracic Neurenteric Cyst after Subtotal Resection: A Case Report
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Tomohiro Yamada, Tomohiko Hasegawa, Yu Yamato, Go Yoshida, Sho Kobayashi, Tatsuya Yasuda, Tomohiro Banno, Hideyuki Arima, Shin Oe, Yuki Mihara, Hiroki Ushirozako, Daisuke Togawa, and Yukihiro Matsuyama
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neurenteric cysts ,cyst recurrence ,subtotal excision ,Surgery ,RD1-811 - Published
- 2020
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31. Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study
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Hiroki Ushirozako, Go Yoshida, Daisuke Togawa, Takao Omura, Tomohiko Hasegawa, Yu Yamato, Tomohiro Banno, Hideyuki Arima, Shin Oe, Yuki Mihara, Tomohiro Yamada, Takahiro Natsume, Shinya Ogawa, Yuji Awaga, Hiroyuki Takamatsu, and Yukihiro Matsuyama
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chymopapain ,discogenic low back pain ,nonhuman primate ,pressure test ,brain activation ,functional magnetic resonance imaging ,secondary somatosensory cortex ,insular cortex ,Surgery ,RD1-811 - Abstract
Introduction: There is currently a lack of translatable, preclinical models of low back pain (LBP). Chymopapain, a proteolytic enzyme used to treat lumbar intervertebral disc (IVD) herniation, could induce discogenic LBP. The current study developed a behavioral model of discogenic LBP in nonhuman primates. Significant brain activation is observed in clinical LBP. Thus, the current study also sought to define brain activation over time in a macaque with discogenic LBP. Methods: Responses to pressure applied to the back at L4/L5 were measured in eight adult male Macaca fasciculata using a pressure algometer. The nucleus pulpous of the IVD between L4 and L5 was aspirated and chymopapain (1 mg/mL) was injected under fluoroscopic guidance (n = 2). In two macaques, the nucleus pulpous was only aspirated. Brain activation in response to pressure applied to the lower back was assessed using a 3.0T magnetic resonance imaging scanner in four macaques before and 1, 3, 9, and 14 days after treatment. Results: The mean (±SD) response pressure before treatment was 1.4 ± 0.1 kg. One day after chymopapain treatment, the response pressure decreased to 0.6 ± 0.05 kg (P < 0.01), suggestive of pressure hypersensitivity. Over time, the pressure thresholds following chymopapain treatment gradually returned to normal. Following aspiration only, the response pressure was 1.4 ± 0.05 kg, which was not significantly different from the uninjured controls. There was activation of the secondary somatosensory cortex and insular cortex one and three days after chymopapain treatment; there was no activation following aspiration only. Conclusions: Enzymatic treatment of the nucleus pulpous leads to acute LBP and pressure-evoked activation in pain-related brain areas. The current model of discogenic LBP parallels clinical LBP and could be used to further elaborate the mechanism of acute LBP.
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- 2019
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32. Preoperative prognostic nutritional index as a predictive factor for medical complication after cervical posterior decompression surgery: A multicenter study
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Kenta Kurosu, Shin Oe, Tomohiko Hasegawa, Satoshi Shimizu, Go Yoshida, Sho Kobayashi, Tomotada Fujita, Tomohiro Yamada, Koichiro Ide, Yuh Watanabe, Keiichi Nakai, Yu Yamato, Tatsuya Yasuda, Tomohiro Banno, Hideyuki Arima, Yuki Mihara, Hiroki Ushirozako, and Yukihiro Matsuyama
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Orthopedic surgery ,RD701-811 - Abstract
Study design: Retrospective longitudinal cohort study. Objective: To investigate postoperative medical complications in patients with malnutrition after cervical posterior surgery. Methods: A total of 256 patients were participated and divided into PNI < 50 group (group L) or PNI ≥ 50 (group H). Patient data, preoperative laboratory data, surgical data, hospitalization data, JOA score, complication data were measured. Results: Group L and group H were 127 and 129 patients, each PNI was L: 44.8 ± 4.3, H: 54.6 ± 4.0, P < 0.01. There was significant difference in mean age (L: 72.2 years vs H: 64.8 years, P < 0.01), BMI (23.1 vs 24.7, P < 0.01), serum albumin (L: 3.9 ± 0.4 g/dl vs H: 4.4 ± 0.3 g/dl, P < 0.01), total lymphocyte count (L: 1.3 ± 0.5 10 3 /µL vs H: 2.1 ± 0.7 10 3 /μL, P < 0.01), hospital stay (L: 25.0 days vs H: 18.8 days, P < 0.05), discharge to home (87.5% vs 57.5%, P < 0.01), delirium (L: 15.9% vs H: 3.9%, P < 0.01), medical complications (L: 25.2% vs H: 7.0%, P < 0.01), pre- and post- operative JOA score (L: 11.3 ± 2.8 vs H: 12.4 ± 2.6, P < 0.01; L: 13.3 ± 3.0 vs H: 14.1 ± 2.4, P = 0.02). Multiple logistic regression analysis showed that significant risk factors for medical complications were PNI
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- 2021
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33. The Current Status and Future Prospects of KAGRA, the Large-Scale Cryogenic Gravitational Wave Telescope Built in the Kamioka Underground
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Homare Abe, Tomotada Akutsu, Masaki Ando, Akito Araya, Naoki Aritomi, Hideki Asada, Yoichi Aso, Sangwook Bae, Rishabh Bajpai, Kipp Cannon, Zhoujian Cao, Eleonora Capocasa, Man Leong Chan, Dan Chen, Yi-Ru Chen, Marc Eisenmann, Raffaele Flaminio, Heather K. Fong, Yuta Fujikawa, Yuya Fujimoto, I. Putu Wira Hadiputrawan, Sadakazu Haino, Wenbiao Han, Kazuhiro Hayama, Yoshiaki Himemoto, Naoatsu Hirata, Chiaki Hirose, Tsung-Chieh Ho, Bin-Hua Hsieh, He-Feng Hsieh, Chia-Hsuan Hsiung, Hsiang-Yu Huang, Panwei Huang, Yao-Chin Huang, Yun-Jing Huang, David C. Y. Hui, Kohei Inayoshi, Yuki Inoue, Yousuke Itoh, Pil-Jong Jung, Takaaki Kajita, Masahiro Kamiizumi, Nobuyuki Kanda, Takashi Kato, Chunglee Kim, Jaewan Kim, Young-Min Kim, Yuichiro Kobayashi, Kazunori Kohri, Keiko Kokeyama, Albert K. H. Kong, Naoki Koyama, Chihiro Kozakai, Jun’ya Kume, Sachiko Kuroyanagi, Kyujin Kwak, Eunsub Lee, Hyung Won Lee, Ray-Kuang Lee, Matteo Leonardi, Kwan-Lok Li, Pengbo Li, Lupin Chun-Che Lin, Chun-Yu Lin, En-Tzu Lin, Hong-Lin Lin, Guo-Chin Liu, Ling-Wei Luo, Miftahul Ma’arif, Yuta Michimura, Norikatsu Mio, Osamu Miyakawa, Kouseki Miyo, Shinji Miyoki, Nozomi Morisue, Kouji Nakamura, Hiroyuki Nakano, Masayuki Nakano, Tatsuya Narikawa, Lan Nguyen Quynh, Takumi Nishimoto, Atsushi Nishizawa, Yoshihisa Obayashi, Kwangmin Oh, Masatake Ohashi, Tomoya Ohashi, Masashi Ohkawa, Yoshihiro Okutani, Ken-ichi Oohara, Shoichi Oshino, Kuo-Chuan Pan, Alessandro Parisi, June Gyu Park, Fabián E. Peña Arellano, Surojit Saha, Kazuki Sakai, Takahiro Sawada, Yuichiro Sekiguchi, Lijing Shao, Yutaka Shikano, Hirotaka Shimizu, Katsuhiko Shimode, Hisaaki Shinkai, Ayaka Shoda, Kentaro Somiya, Inhyeok Song, Ryosuke Sugimoto, Jishnu Suresh, Takamasa Suzuki, Takanori Suzuki, Toshikazu Suzuki, Hideyuki Tagoshi, Hirotaka Takahashi, Ryutaro Takahashi, Hiroki Takeda, Mei Takeda, Atsushi Taruya, Takayuki Tomaru, Tomonobu Tomura, Lucia Trozzo, Terrence T. L. Tsang, Satoshi Tsuchida, Takuya Tsutsui, Darkhan Tuyenbayev, Nami Uchikata, Takashi Uchiyama, Tomoyuki Uehara, Koh Ueno, Takafumi Ushiba, Maurice H. P. M. van Putten, Tatsuki Washimi, Chien-Ming Wu, Hsun-Chung Wu, Tomohiro Yamada, Kazuhiro Yamamoto, Takahiro Yamamoto, Ryo Yamazaki, Shu-Wei Yeh, Jun’ichi Yokoyama, Takaaki Yokozawa, Hirotaka Yuzurihara, Simon Zeidler, and Yuhang Zhao
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gravitational wave detector ,laser interferometer ,cryogenics ,underground ,Astronomy ,QB1-991 - Abstract
KAGRA is a gravitational-wave (GW) detector constructed in Japan with two unique key features: It was constructed underground, and the test-mass mirrors are cooled to cryogenic temperatures. These features are not included in other kilometer-scale detectors but will be adopted in future detectors such as the Einstein Telescope. KAGRA performed its first joint observation run with GEO600 in 2020. In this observation, the sensitivity of KAGRA to GWs was inferior to that of other kilometer-scale detectors such as LIGO and Virgo. However, further upgrades to the detector are ongoing to reach the sensitivity for detecting GWs in the next observation run, which is scheduled for 2022. In this article, the current situation, sensitivity, and future perspectives are reviewed.
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- 2022
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34. Histological and Immunohistochemical Studies to Determine the Mechanism of Cleft Palate Induction after Palatal Fusion in Mice Exposed to TCDD
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Chisato Sakuma, Hideto Imura, Tomohiro Yamada, Azumi Hirata, Yayoi Ikeda, Masaaki Ito, and Nagato Natsume
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cleft lip ,cleft palate ,palatal fusion ,rupture ,TCDD ,epithelial cell adhesion ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Rupture of the basement membrane in fused palate tissue can cause the palate to separate after fusion in mice, leading to the development of cleft palate. Here, we further elucidate the mechanism of palatal separation after palatal fusion in 8–10-week-old ICR female mice. On day 12 of gestation, 40 μg/kg of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), sufficient to cause cleft palate in 100% of mice, was dissolved in 0.4 mL of olive oil containing toluene and administered as a single dose via a gastric tube. Fetal palatine frontal sections were observed by H&E staining, and epithelial cell adhesion factors, apoptosis, and cell proliferation were observed from the anterior to posterior palate. TUNEL-positive cells and Ki67-positive cells were observed around the posterior palatal dissection area of the TCDD-treated group. Moreover, in fetal mice exposed to TCDD, some fetuses exhibited cleft palate dehiscence during fusion. The results suggest that palatal dehiscence may be caused by abnormal cell proliferation in epithelial tissues, decreased intercellular adhesion, and inhibition of mesenchymal cell proliferation. By elucidating the mechanism of cleavage after palatal fusion, this research can contribute to establishing methods for the prevention of cleft palate development.
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- 2022
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35. Characterization of zolbetuximab in pancreatic cancer models
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Ӧzlem Türeci, Rita Mitnacht-Kraus, Stefan Wöll, Tomohiro Yamada, and Ugur Sahin
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claudin 18.2 ,zolbetuximab ,imab362 ,monoclonal antibody ,targeted therapy ,pancreatic cancer ,antibody-dependent cellular cytotoxicity ,adcc ,complement-dependent cytotoxicity ,immunotherapy ,Immunologic diseases. Allergy ,RC581-607 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In healthy tissue, the tight junction protein Claudin 18.2 (CLDN18.2) is present only in the gastric mucosa. Upon malignant transformation of gastric epithelial tissue, perturbations in cell polarity lead to cell surface exposure of CLDN18.2 epitopes. Moreover, CLDN18.2 is aberrantly expressed in malignancies of several other organs, such as pancreatic cancer (PC). A monoclonal antibody, zolbetuximab (formerly known as IMAB362), has been generated against CLDN18.2. In a phase 2 clinical trial (FAST: NCT01630083), zolbetuximab in conjunction with chemotherapy prolonged overall and progression-free survival over chemotherapy alone and improved quality of life. In this study, the mechanism of action and antitumor activity of zolbetuximab were investigated using nonclinical PC models. Zolbetuximab bound specifically and with strong affinity to human PC cells that expressed CLDN18.2 on the cell surface. In ex vivo systems using immune effector cells and serum from healthy donors, zolbetuximab induced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), resulting in the lysis of cultured human PC cells. The amplitude of ADCC and CDC directly correlated with cell surface CLDN18.2 levels. The chemotherapeutic agent gemcitabine upregulated CLDN18.2 expression in cultured human PC cells and enhanced zolbetuximab-induced ADCC. In mouse xenograft tumors derived from human PC cell lines, including gemcitabine-refractory ones, zolbetuximab slowed tumor growth, benefited survival, and attenuated metastases development. The results presented here validate CLDN18.2 as a targetable biomarker in PC and support extension of the clinical development of zolbetuximab to patients with CLDN18.2-expressing PC.
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- 2019
- Full Text
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36. Comprehensive Metabolite Profiling in Genetic Resources of Garlic (Allium sativum L.) Collected from Different Geographical Regions
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Mostafa Abdelrahman, Sho Hirata, Takuya Mukae, Tomohiro Yamada, Yuji Sawada, Magdi El-Syaed, Yutaka Yamada, Muneo Sato, Masami Yokota Hirai, and Masayoshi Shigyo
- Subjects
garlic ,saponins ,fructan ,metabolome profiles ,Organic chemistry ,QD241-441 - Abstract
Garlic (Allium sativum) is the second most important Allium crop that has been used as a vegetable and condiment from ancient times due to its characteristic flavor and taste. Although garlic is a sterile plant that reproduces vegetatively through cloves, garlic shows high biodiversity, as well as phenotypic plasticity and environmental adaptation capacity. To determine the possible mechanism underlying this phenomenon and to provide new genetic materials for the development of a novel garlic cultivar with useful agronomic traits, the metabolic profiles in the leaf tissue of 30 garlic accessions collected from different geographical regions, with a special focus on the Asian region, were investigated using LC/MS. In addition, the total saponin and fructan contents in the roots and cloves of the investigated garlic accessions were also evaluated. Total saponin and fructan contents did not separate the garlic accessions based on their geographical origin, implying that saponin and fructan contents were clone-specific and agroclimatic changes have affected the quantitative and qualitative levels of saponins in garlic over a long history of cultivation. Principal component analysis (PCA) and dendrogram clustering of the LC/MS-based metabolite profiling showed two major clusters. Specifically, many Japanese and Central Asia accessions were grouped in cluster I and showed high accumulations of flavonol glucosides, alliin, and methiin. On the other hand, garlic accessions grouped in cluster II exhibited a high accumulation of anthocyanin glucosides and amino acids. Although most of the accessions were not separated based on country of origin, the Central Asia accessions were clustered in one group, implying that these accessions exhibited distinct metabolic profiles. The present study provides useful information that can be used for germplasm selection and the development of new garlic varieties with beneficial biotic and abiotic stress-adaptive traits.
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- 2021
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37. Plasmablastic lymphoma of the upper gingiva in an HIV-negative elderly patient
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Tomohiro Yamada, DDS, PhD, Naoya Kitamura, DDS, PhD, Eri Sasabe, DDS, PhD, and Tetsuya Yamamoto, DDS, PhD
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Plasmablastic lymphoma ,HIV negative ,Oral ,Gingiva ,Maxilla ,Surgery ,RD1-811 - Abstract
Plasmablastic lymphoma (PBL) is a highly aggressive variant of diffuse large B-cell lymphoma and is usually treated by chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP-like regimens. However, elderly patients tend to have difficulty with the chemotherapy. We successfully treated an HIV-negative elderly PBL patient with surgery alone. An 87-year-old Japanese man was referred to our hospital because of gingival swelling of the left maxilla. After several examinations, a multilobular 3-cm tumor of the left maxilla and lymph node swelling on the left side of the neck were revealed. The patient was HIV negative and human T-cell leukemia virus negative. He was diagnosed with PBL, or undifferentiated carcinoma/sarcoma, and we performed surgical therapy, radical neck dissection, and a partial maxillectomy. The surgical margin of the resected specimen was negative for tumor cells, and 6 of 27 lymph nodes contained tumor cells. Histologically, the tumor consisted of basophilic large cells with deviated nuclei. Together with the immunohistochemical findings, the final diagnosis was PBL. The patient and his family did not agree to chemotherapy. Nineteen months after surgery, he is fine and no signs of recurrence were observed. Surgery-only therapy may be a reasonable alternative for elderly PBL patients.
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- 2015
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38. Anti-Idiotype DNA Aptamer Affinity Purification–High-Temperature Reversed-Phase Liquid Chromatography: A Simple, Accurate, and Selective Bioanalysis of Bevacizumab
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Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Hideki Hayashi, Hajime Mizuno, Daiki Tsuji, Keisuke Yamamoto, Kunihiko Itoh, Toshimasa Toyo’oka, Kazunori Ikebukuro, and Kenichiro Todoroki
- Subjects
aptamer affinity purification ,high-temperature reversed-phase liquid chromatography ,immunoaffinity purification ,bevacizumab ,Organic chemistry ,QD241-441 - Abstract
This study presents a simple, accurate, and selective bioanalytical method of bevacizumab detection from plasma samples based on aptamer affinity purification⁻high-temperature reversed-phased liquid chromatography (HT-RPLC) with fluorescence detection. Bevacizumab in plasma samples was purified using magnetic beads immobilized with an anti-idiotype DNA aptamer for bevacizumab. The purified bevacizumab was separated with HT-RPLC and detected with its native fluorescence. Using aptamer affinity beads, bevacizumab was selectively purified and detected as a single peak in the chromatogram. HT-RPLC achieved good separation for bevacizumab with a sharp peak within 10 min. The calibration curves of the two monoclonal antibodies ranged from 1 to 50 μg/mL and showed good correlation coefficients (r2 > 0.999). The limit of detection (LOD) and lower limit of quantification (LLOQ) values for bevacizumab were 0.15 and 0.51 μg/mL, respectively. The proposed method was successfully applied to the bioanalysis of the plasma samples obtained from the patients with lung cancer and may be extended to plan optimal therapeutic programs and for the evaluation of biological equivalencies in the development of biosimilars.
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- 2019
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39. Psychosocial stress enhances IgE-mediated triphasic cutaneous reaction in mice: Antagonism by Yokukan-san (a Kampo medicine) and diazepam
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Eiichi Tahara, Wenjuan Wu, Taku Satoh, Tomohiro Yamada, lzumi Kurosaki, Hiroichi Nagai, Shinyu Nunome, Katsutoshi Terasawa, and Ikuo Saiki
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atopic dermatitis ,diazepam ,IgE-mediated skin reaction ,Kampo medicine ,psychosocial stress ,social isolation stress ,Yokukan-san ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: In the present study, we investigated the effect of social isolation stress on IgE-mediated triphasic cutaneous reactions after 2,4-dinitrofluorobenzene (DNFB) challenge in male BALB/c mice passively sensitized with anti-dinitrophenol (DNP) IgE antibody, and examined the effects of Yokukan-san (a Kampo medicine with antipsychotic action) and a reference drug (diazepam) on the stress-enhanced cutaneous reaction. Methods/Results: In response to challenge with 0.01, 0.025 and 0.05% DNFB, triphasic skin reactions, including an immediate-phase response (IPR), a late-phase response (LPR) and a very late-phase response (vLPR) at 1 and 24 h and 8 days after antigen challenge, respectively, were increased in socially isolated mice compared with group-housed mice. Oral administration of Yokukan-san attenuated the isolation stress-exacerbated triphasic skin reactions in a dose-dependent manner, whereas it had no significant effect on cutaneous reactions in the unstressed group-housed mice. In contrast, intraperitoneal administration of diazepam, a classic benzodiazepine receptor agonist, suppressed the enhanced IPR and LPR in socially isolated mice but, surprisingly, stimulated vLPR in both stressed and unstressed mice, showing different efficacy to Yokukan-san. Moreover, the elevated locomotor activity in socially isolated mice was reduced by Yokukan-san and diazepam, while the isolation stress-induced aggressive behavior was normalized only by diazepam and not by Yokukan-san. Conclusions: The results of the present study indicate that IgE-mediated triphasic cutaneous reactions were exacerbated by social isolation stress and suggest that Yokukan-san and diazepam antagonize isolation stress-induced cutaneous reactions partly through their sedative action on social isolation stress.
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- 2001
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40. Topology optimization analysis for minimization of strain energy using the modified optimality criteria method.
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Masayuki Kishida, Takahiko Kurahashi, Taichi Yoshiara, Ryohei Kaneko, Yuta Ishii, Wataru Nishioka, Tomohiro Yamada, and Masanari Kobayashi
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- 2022
- Full Text
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41. Comparison of Skeletal Stability after Le Fort I Osteotomy With Bone Fixation Using Biodegradable and Titanium Systems: A Retrospective Study.
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Rena Shido, Seigo Ohba, Emi Moriuchi, Gou Yasuda, Masahito Hara, Shun Narahara, Kinuko Ogata, Noriaki Yoshida, and Tomohiro Yamada
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- 2024
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42. Paget’s disease of bone involving the mandible may causes temporomandibular joint ankylosis: A case report
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Minami Shibuya, Kotaro Ishii, Koki Nagano, Takahiro Fujinaga, Yuta Yanai, Tomohiro Yamada, Yuko Wada, Mayumi Shimizu, and Yoshihide Mori
- Subjects
Otorhinolaryngology ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2023
43. Mandibular metastasis from prostate cancer that clinically mimicked osteosarcoma: A case report
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Ikumi Imajo, Tomohiro Yamada, Takahiro Fujinaga, Koki Nagano, Wataru Kumamaru, Yuta Yanai, Toru Chikui, and Tamotsu Kiyoshima
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Otorhinolaryngology ,Surgery ,Oral Surgery ,Pathology and Forensic Medicine - Published
- 2023
44. Decision-Making Prediction for Human-Robot Engagement between Pedestrian and Robot Receptionist.
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Yasunori Ozaki, Tatsuya Ishihara, Narimune Matsumura, Tadashi Nunobiki, and Tomohiro Yamada
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- 2018
- Full Text
- View/download PDF
45. R-R Interval Outlier Exclusion Method Based on Statistical ECG Values Targeting HRV Analysis Using Wearable ECG Devices.
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Kana Eguchi, Ryosuke Aoki, Kazuhiro Yoshida, and Tomohiro Yamada
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- 2018
- Full Text
- View/download PDF
46. Consideration of Calculation Process Assuming Heart Rate Variability Analysis Using Wearable ECG Devices.
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Ryosuke Aoki, Kana Eguchi, Suehiro Shimauchi, Kazuhiro Yoshida, and Tomohiro Yamada
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- 2018
- Full Text
- View/download PDF
47. Where Should Robots Talk?: Spatial Arrangement Study from a Participant Workload Perspective.
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Takahiro Matsumoto, Mitsuhiro Goto, Ryo Ishii, Tomoki Watanabe, Tomohiro Yamada, and Michita Imai
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- 2018
- Full Text
- View/download PDF
48. Marked Temporal Point Processes for Trip Demand Prediction in Bike Sharing Systems.
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Maya Okawa, Yusuke Tanaka 0002, Takeshi Kurashima, Hiroyuki Toda, and Tomohiro Yamada
- Published
- 2019
- Full Text
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49. Effect of Unintended Tissue Injury on the Development of Thigh Symptoms After Lateral Lumbar Interbody Fusion in Patients With Adult Spinal Deformity.
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Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Tomohiro Banno, Shin Oe, MD, Hideyuki Arima, Koichiro Ide, Tomohiro Yamada, Kenta Kurosu, Keiichi Nakai, and Yukihiro Matsuyama
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- 2024
- Full Text
- View/download PDF
50. Medical complications following adult spinal deformity correction in patients with autoimmune disease
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Rina Therese R. Madelar, Shin Oe, Yu Yamato, Tomohiko Hasegawa, Go Yoshida, Tomohiro Banno, Hideyuki Arima, Koichiro Ide, Tomohiro Yamada, Kenta Kurosu, Keiichi Nakai, and Yukihiro Matsuyama
- Subjects
General Medicine - Abstract
OBJECTIVE An aberrant inflammatory response, which plays a role in the development of postoperative complications, is observed in autoimmune diseases, Yet, there is a paucity of literature regarding the effects of autoimmune diseases after adult spinal deformity (ASD) surgery. The goal of this study was to determine the effects of autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus) on postoperative medical complications, patient-reported outcome measures (PROMs), and radiographic alignment in patients who underwent ASD surgery. METHODS Propensity-score matching for age and sex was performed for patients with autoimmune disease (group A) and nonautoimmune patients (group NA1). Postoperative medical complications, preoperative and 2-year follow-up PROMs, and preoperative, immediate postoperative, and 2-year follow-up radiographic alignment were evaluated. RESULTS Among 386 patients (27 in group A and 359 in group NA1), autoimmune patients had a higher incidence of respiratory complications (11.1% vs 2.2%, p = 0.036), gastrointestinal complications (14.8% vs 3.1%, p = 0.016), urinary tract infections (14.8% vs 3.1%, p = 0.016), cholecystitis (7.4% vs 0%, p = 0.005), and fever of unknown origin (14.8% vs 0%, p < 0.001). Autoimmune patients had worse preoperative ODI (54.2 vs 44.7, p = 0.004) and 2-year follow-up Scoliosis Research Society 22-item Questionnaire (SRS-22) scores (3.1 vs 3.5, p = 0.039), with higher preoperative sacral slope (23.4° vs 17.8°, p = 0.020). Propensity-score matching for age and sex yielded 27 pairs (group A and group NA2). Having at least one medical complication (group A 74.1% vs group NA2 22.2%, p < 0.001), total complications per person (1.3 vs 0.3, p = 0.010), prognostic nutrition index (44.8 vs 48.6, p = 0.034), steroid use (51.9% vs 0%, p < 0.001), immunosuppressant use (48.1% vs 0%, p < 0.001), length of hospital stay (38 vs 27 days, p = 0.018), and discharge to care facility (29.6% vs 7.4%, p = 0.036) were higher in group A. Preoperative ODI (54.2 vs 43.2, p = 0.011) and 2-year follow-up SRS-22 scores (3.1 vs 3.6 p = 0.019) were worse in group A. No differences were observed in radiographic alignment. CONCLUSIONS Patients with autoimmune disease had higher complication rates and worse PROMs following ASD surgery in this study. There was no difference in spinal alignment compared with controls. Multidisciplinary planning and full disclosure of possible adverse effects should be completed prior to correction of ASD in patients with autoimmune disease.
- Published
- 2023
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