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Background The purpose of this study was to evaluate true change in leg length after open-wedge high tibial osteotomy (OWHTO) using three-dimensional (3D) assessments, examine the factors that influence leg lengthening and verify their validity in clinical practice. Methods Study 1: a retrospective case series simulation study, included 46 patients (55 knees) that underwent knee arthroplasty or HTO. OWHTO was simulated from preoperative computed tomography using 3D preoperative planning software. Uni- and multivariate regression analyses were conducted to identify predictors related to change in leg length. Study 2: a retrospective case series study, included 53 patients (55 knees) that underwent OWHTO in another institution. Change in leg length was measured preoperatively and 1 year postoperatively and was compared with the predicted change in leg length calculated using the formula obtained from Study 1. Results Study 1: the true change in leg length significantly increased and showed a strong correlation with the opening width. The change in leg length was predicted using the formula “change in leg length = opening width × 0.75–1.5.” Study 2: the predicted change in leg length showed no significant difference from the change in leg length 1 year postoperatively and a strong correlation with the measured change. Conclusions The true change in leg length after OWHTO was predicted using the formula obtained from the 3D model. Predicting the change in leg length preoperatively can be a basis to consider other HTOs.

Background Locomotive syndrome (LS) is a predictive factor of future motor dysfunction. Our aim was to evaluate the change in the total LS grade and, its the association with the Japanese Orthopaedic Association (JOA) hip score after total hip arthroplasty (THA) among patients with hip osteoarthritis. Methods This was a prospective case-control study of 72 patients who underwent primary THA. The functional outcomes were measured before, and at 6 and 12 months after THA. LS was evaluated using the following tests: stand-up test, 2-step test, and 25-question Geriatric Locomotive Function Scale (GLFS-25). In addition, factors affecting the improvement of LS grade were examined. Results Prior to THA, 7% and 93% of patients were classified as LS grades 1 and 2. At 6 months after THA, an improvement in the total LS grade was observed in 57% of patients, with this percentage further increasing to 65% at 1 year. Only the preoperative GLFS-25 was correlated with the preoperative JOA hip scores. The postoperative GLFS-25 and the two-step test were correlated with the postoperative JOA hip scores. The preoperative functional reach test (FRT) was significantly correlated with the total LS grade improvement. Conclusions THA can improve the total LS grade in 65% of patients at 1 year postoperatively. Improvement was largely achieved in the first 6 months after THA, with a change from LS grade 2 to grade 1. FRT could be used an indicator of the total LS grade improvement.

Background:In total hip arthroplasty with computer navigation assistance, cup orientation is generally determined according to the coordinate system relative to the functional pelvic plane (FPP). However, there is a large difference in the cup anteversion between a posterior pelvic tilt relative to the computed tomography (CT) table in the sagittal plane and anterior pelvic tilt, even when the cup is set at the same orientation angle according to each FPP. The present study analysed this difference from the viewpoint of 3-dimensional (3D) coverage of the acetabular component (3D coverage) to determine how the 3D acetabular coverage is altered with changes in pelvic sagittal tilt.Methods:We analysed 3D-simulated acetabular coverage measured in 3D pelvic models reconstructed from the preoperative CT data of 50 patients. In each patient, we created 5 pelvic models with a sagittal tilt of 10° increments between 20° anterior tilt and 20° posterior tilt relative to the CT table.Results:We found that 3D coverage decreased as the pelvis tilted posteriorly. Particularly, there were significant differences between the pelvis with 20° anterior tilt and that with neutral tilt ( p < 0.001). There was also a difference between the pelvis with neutral tilt and that with a 20° posterior tilt ( p < 0.01). The mean decrease in 3D coverage between the pelvis with neutral tilt and that with 20° posterior tilt was 7.2 ± 1.6%.Conclusions:We found that 3D coverage differed among pelvis with different sagittal tilts when the cup orientation angle was determined according to FPP.

BACKGROUND: We developed iodine-coated titanium implants to suppress microbial activity and prevent periprosthetic joint infection (PJI); their efficacy was demonstrated in animal and in vitro models. The iodine content in iodine-coated implants naturally decreases in vivo. However, to our knowledge, the effect of reduced iodine content on the implant’s antimicrobial activity has not been evaluated to date. QUESTIONS/PURPOSES: (1) How much does the iodine content on the implant surface decrease after 4 and 8 weeks in vivo in a rat model? (2) What effect does the reduced iodine content have on the antimicrobial effect of the implant against multiple bacteria in an in vitro model? METHODS: This experiment was performed in two parts: an in vivo experiment to determine attenuation of iodine levels over time in rats, and an in vitro experiment in which we sought to assess whether the reduced iodine content observed in the in vivo experiment was still sufficient to deliver antimicrobial activity against common pathogens seen in PJI. For the in vivo experiment, three types of titanium alloy washers were implanted in rats: untreated (Ti), surface-anodized to produce an oxide film (Ti-O), and with an iodine layer on the oxidation film (Ti-I). The attenuation of iodine levels in rats was measured over time using inductively coupled plasma-mass spectrometry. Herein, only the Ti-I washer was used, with five implanted in each rat that were removed after 4 or 8 weeks. For the 4- and 8-week models, two rats and 15 washers were used. For the in vitro study, to determine the antibacterial effect, three types of washers (Ti, Ti-O, and Ti-I) (nine washers in total) were implanted in each rat. Then, the washers were removed and the antibacterial effect of each washer was examined on multiple bacterial species using the spread plate method and fluorescence microscopy. For the spread plate method, six rats were used, and five rats were used for the observation using fluorescence microscopy; further, 4- and 8-week models were made for each method. Thus, a total of 22 rats and 198 washers were used. Live and dead bacteria in the biofilm were stained, and the biofilm coverage percentage for quantitative analysis was determined using fluorescence microscopy in a nonblinded manner. Ti-I was used as the experimental group, and Ti and Ti-O were used as control groups. The total number of rats and washers used throughout this study was 24 and 213, respectively. RESULTS: Iodine content in rats implanted with Ti-I samples decreased to 72% and 65% after the in vivo period of 4 and 8 weeks, respectively (p = 0.001 and p < 0.001, respectively). In the in vitro experiment, the Ti-I implants demonstrated a stronger antimicrobial activity than Ti and Ti-O implants in the 4- and 8-week models. Both the median number of bacterial colonies and the median biofilm coverage percentage with live bacteria on Ti-I were lower than those on Ti or Ti-O implants for each bacterial species in the 4- and 8-week models. There was no difference in the median biofilm coverage percentage of dead bacteria. In the 8-week model, the antibacterial activity using the spread plate method had median (interquartile range) numbers of bacteria on the Ti, Ti-O, and Ti-I implants of 112 (104 to 165) × 10(5), 147 (111 to 162) × 10(5), and 55 (37 to 67) × 10(5) of methicillin-sensitive Staphylococcus aureus (Ti-I versus Ti, p = 0.026; Ti-I versus Ti-O, p = 0.009); 71 (39 to 111) × 10(5), 50 (44 to 62) × 10(5), and 26 (9 to 31)× 10(5) CFU of methicillin-resistant S. aureus (Ti-I versus Ti, p = 0.026; Ti-I versus Ti-O, p = 0.034); and 77 (74 to 83) × 10(6), 111 (95 to 117) × 10(6), and 30 (21 to 45) × 10(6) CFU of Pseudomonas aeruginosa (Ti-I versus Ti, p = 0.004; Ti-I versus Ti-O, p = 0.009). Despite the decrease in the iodine content of Ti-I after 8 weeks, it demonstrated better antibacterial activity against all tested bacteria than the Ti and Ti-O implants. CONCLUSION: Iodine-coated implants retained their iodine content and antibacterial activity against methicillin-sensitive S. aureus, methicillin-resistant S. aureus, and P. aeruginosa for 8 weeks in vivo in rats. To evaluate the longer-lasting antibacterial efficacy, further research using larger infected animal PJI models with implants in the joints of both males and females is desirable. CLINICAL RELEVANCE: Iodine-coated titanium implants displayed an antibacterial activity for 8 weeks in rats in vivo. Although the findings in a rat model do not guarantee efficacy in humans, they represent an important step toward clinical application.

Background Subcutaneous adipose tissue represents an abundant source of multipotent adult stem cells named as Adipose-derived stem cells (ADSCs). With a cell sheet approach, ADSCs survive longer, and can be delivered in large quantities. We investigated whether intra-articular ADSC sheets attenuated osteoarthritis (OA) progression in a rabbit anterior cruciate ligament transection (ACLT) model. Methods Fabricating medium containing ascorbate-2-phosphate was used to enhance collagen protein secretion by the ADSCs to make ADSC sheets. At 4 weeks after ACLT, autologous ADSC sheets were injected intra-articularly into the right knee (ADSC sheets group), and autologous cell death sheets treated by liquid nitrogen were injected into the left knee (control group). Subsequent injections were administered once weekly. Femoral condyles were compared macroscopically and histologically. Results Macroscopically, OA progression was significantly milder in the ADSC sheets than in the control groups. Histologically, control knees showed obvious erosions in the medial and lateral condyles, while cartilage was retained predominantly in the ADSC sheets group. Immunohistochemically, MMP-1, MMP-13, ADAMTS-4 were less expressive in the ADSC sheets than in the control groups. Conclusions Periodic ADSC sheets injections inhibited articular cartilage degeneration without inducing any adverse effects. A large quantity of autologous ADSCs delivered by cell sheets homed to the synovium and protected chondrocytes.

A computed tomography (CT)-based hip navigation system is a useful tool for achieving precise implant alignment angle. However, it has the disadvantage of prolonged procedure duration. A prolonged procedure duration may increase the incidence of postoperative surgical site infection (SSI) or periprosthetic joint infection (PJI) following primary THA. Studies identifying whether CT-based hip navigation system increases the incidence of SSI and PJI compared to the free-hand technique for total hip arthroplasty (THA) are rare. The study aimed to assess whether the CT-based hip navigation system can cause SSI and PJI compared to the free-hand technique. We investigated 366 patients with osteoarthritis who completed the minimum 2-year follow-up and underwent primary THAs (n = 435), including 70 hips in 62 patients of the non-navigation group and 365 hips in 304 patients of the navigation group. We compared the incidence rate of SSI and PJI between the non-navigation group and navigation group. Only three patients in the navigation group (0.8%) developed SSI or PJI, while no patient developed SSI or PJI in the non-navigation group. There was no significant difference in the incidence rate of SSI or PJI between the two groups (P = 1.0), although the mean operation time in the navigation group was about 20 min longer. CT-based hip navigation system may not be associated with SSI or PJI after primary THA, although it prolongs the operation time.

In THA, using a larger femoral head can increase the oscillation angle and jumping distance. However, there have been no reports which indicate precisely how increasing the jumping distance leads to an increase in the angle from impingement to dislocation (jumping angle). In this study, we clarified the jumping angle of various head diameters and its relationship with pelvic morphology. Using a three-dimensional templating system, virtual THA and ROM simulations were performed in 82 patients. We investigated the distance between bony and prosthetic impingement points and the head centre and calculated the jumping angle for various head diameters. We measured various pelvic shapes and length to clarify the relationship between pelvic morphology and impingement distance. Jumping angles were 7.7° ± 3.2°, 12.1° ± 1.6°, 15.4° ± 2.5° and 10.0° ± 3.0° with flexion, internal rotation with 90° flexion (IR), extension and external rotation (ER), respectively, when we used a 22-mm head diameter. Bony jumping angle increased about 0.5°, 0.8°, 1.0° and 0.7° per 2-mm increase in head diameter with flexion, IR, extension and ER. On the other hand, prosthetic jumping angle remained almost stable at about 31°. Impingement distance was related to pelvic morphology in all directions. Bony jumping angles differed with ROM; the biggest was seen with extension, followed by IR, ER and flexion. On the other hand, bony jumping angle was less than prosthetic jumping angle in all cases. Bony jumping angles differed with ROM; the biggest was seen with extension, followed by IR, ER and flexion. Prosthetic impingement angles were stable. In addition, the bony jumping angle was less than the prosthetic jumping angle in all cases.

Past reports showed good mid-term results of RHA for Japanese patients. However, few reports have compared the mid- to long-term results for RHA in Japanese patients with and without osteoarthritis. Therefore, this study investigated the mid- to long-term results of RHA in Japanese patients with osteoarthritis compared to those without. We conducted a retrospective review of a consecutive series of 92 hips in 80 patients (59 men and 21 women). The minimum follow-up period was 5 years. The JOA hip scoring system was used to clinically evaluate hip function. In the radiological assessment, stem-shaft angle, inclination of the acetabular component, postoperative complications, and adverse reactions around RHA were evaluated. The 10-year survival rate using the Kaplan-Meier method was investigated to compare patients with and without osteoarthritis. A significant difference was observed between the preoperative and postoperative JOA hip scores of either group. Also, the radiological assessment revealed no significant changes in either group. All three revision THAs were performed on patients in the only non-osteoarthritis group. In the osteoarthritis group, the 10-year survival rate was 94% (95% CI 81.8-100) in males and 100% (95% CI 100) for females; in the non-osteoarthritis group, the rate was 80% (95% CI 55.1-100) in males and 66.7% (95% CI 13.3-100) for females. In conclusion, this study showed good mid- to long-term clinical results for young Japanese osteoarthritis patients, with less satisfactory mid- to long-term results in patients without osteoarthritis.

Background One of the serious postoperative complications associated with joint replacement is bacterial infection. In our recent investigations, iodine supported titanium implants demonstrated antibacterial activity in both in vitro and in vivo studies. The surfaces of the implants have porous anodic oxide layer with the antiseptic properties of iodine. According to the literature the titanium with porous anodic oxide have good osteoconductivity. But it is not clear whether the properties of iodine influence bone bonding of implants. Objectives The aim of this study is to evaluate the influence of the properties of iodine and porous anodic oxide layer in the bone bonding ability of titanium implants. Study design & methods Titanium rods were implanted in intramedullary rabbit femur models, in regard to the cementless hip stem. The implant rods were 5 mm in diameter and 25 mm in length. Three types of titanium rods were implanted.One was untreated titanium (control group (CL)), another was titanium with oxide layer without iodine (oxide layer group (OL)), and the other was Iodine treated Titanium (iodine group (ID)). The rods were inserted into the distal femur. We assessed the bonding strength by a measuring pull-out test at 4, 8, and 12 weeks after implantation. The bone-implant interfaces were evaluated at 4 weeks after implantation. Results Pull-out test results of the ID implants were 202, 355, and 344 N, and those of the OL implants were 220, 310, 329 N at 4, 8, and 12 weeks, significantly higher than those of the CL implants (102, 216, and 227 N). But there were no significant difference in ID implants and OL implants. Histological examination revealed that new bone formed on the surface of each types of implants, but significantly more bone made direct contact with the surfaces of the ID implants and OL implants. Conclusions This research showed that new type of coating, iodine coated titanium has low toxicity and good osteoconductivity.

Limb lengthening after total knee arthroplasty (TKA) has been reported in some cases, all of which were evaluated using two-dimensional images. To our knowledge, no case has been evaluated using three-dimensional (3D) images. We investigated 3D limb lengthening after TKA.We simulated 100 varus knees using 3D templating software. Virtual TKA was performed to maintain the original joint line by conducting a measured-resection technique. We examined the relationships of 3D distance between the femoral head center and ankle center before and after TKA, degree of hip-knee-ankle angle (HKA) improvement, and degree of flexion contracture angle improvement.All cases showed limb lengthening (average, 9.4 ± 6.0 mm). The coefficients of correlation with limb lengthening and the degree of HKA improvement and the degree of flexion contracture angle improvement were good (0.730 and 0.751, respectively). The correlation between the degree of total improvement (the degree of HKA improvement + the degree of flexion contracture angle improvement) and limb lengthening was strong (r = 0.896).The expected limb lengthening when performing measured-resection TKA is expressed as 0.58 × (the degree of HKA improvement + the degree of flexion contracture angle improvement) mm and is a useful index.

Past reports have shown the tendency of posterior pelvic tilt to increase over time after total hip arthroplasty (THA). We have hypothesized that the volume and extent of released joint capsule may influence the change in postoperative pelvic tilt. This study was conducted to ascertain whether surgical approach during THA (posterior or anterior) has an effect on postoperative changes in pelvic tilt. We conducted a retrospective review of 81 hips in 60 patients. Patients classified as Crowe group 2, 3, and 4, those who had multiple previous compression fractures, and those with spinal fusion due to spinal arthrosis were excluded. Also, those who had previously undergone THA or total hip resurfacing also were excluded. Patients were divided into two groups, those with preoperative anterior pelvic tilt and those with posterior tilt. Preoperative and postoperative X-rays and CT scans for each group were assessed to determine the chronological change in pelvic tilt, and the data were statistically analyzed for patients who had experienced both the posterior and anterior approaches. Regardless of surgical approach, there was no significant difference in the mean change in postoperative APP angle over time in either the bilateral or unilateral cases or in the groups of preoperative anterior or posterior pelvic tilt. Our results showed that surgical approach does not influence postoperative pelvic tilt after THA. In preoperative planning for THA, therefore, surgeons may need not to consider the difference of surgical approach with regard to postoperative changes in pelvic tilt.

Background Dual mobility cup (DMC) inserts reduce the risk of dislocation after total hip arthroplasty (THA). No available research has clearly delineated stability advantages of DMC inserts in primary and revision THA. We investigated: (i) the degree of change in the safe zone of the cup when a DMC insert is used compared to a fixed insert; (ii) the method of selecting candidates for a DMC insert without changing the position of the acetabular (cup) component during revision THA in frequent dislocation cases caused by implant impingement. Methods A model of the pelvis and femur was developed from computed tomography images. The safe zone was defined as the area in the acetabular component, over which conditions for stable range of motion were satisfied. The safe zone was calculated for both a fixed and a DMC insert over a predetermined range of 3-D motion, and the effect of increasing the anteversion position of the femoral component from 5° to 35° was quantified. Results The lowest ratio of the area of the safe zone was about 4.9 at 20° anteverison of the femoral component. Safe zone of DMC inserts zone had increased stability of 10°-15° in both vertical and horizontal directions, compared to fixed inserts. A 5- to10-fold expansion of the safe zone can be expected with the use of DMC insert. Conclusions DMC insert could help to set the acetabular component more accurately in primary and revision THA.

Background There have been no studies on the differences in impingement-free angle that result from different combined anteversion (CA) patterns. The aim of this study was to find the optimal CA pattern for achieving a favorable impingement-free angle, including bony and prosthetic impingement, in total hip arthroplasty. Methods We evaluated 100 patients with no hip arthritis. We investigated the impingement-free angle (flexion, internal rotation with 90° flexion, extension, and external rotation) after changing the stem and cup anteversions to satisfy several CA patterns [cup anteversion + stem anteversion = 30°, 40°, 50°, and 60°; cup anteversion + 0.7 × stem anteversion = 37.3° (:Widmer's theory); and cup anteversion + 0.77 × stem anteversion = 43.3° (:Yoshimine's theory)] using 3-dimensional templating software. Results The impingement-free angle changed dramatically among the various CA patterns. The optimal CA was changed by various stem anteversion. Only CA: Widmer with stem anteversion of 20° satisfied daily-life range of motion (ROM) requirements (flexion ≥130°, internal rotation with 90° flexion ≥ 45°, extension ≥ 40°, external rotation ≥ 40°). Conclusion Good impingement-free angle cannot be obtained with single fixed CA. Different CA patterns should be used, depending on the differences in the stem anteversion. A CA of 30° with 0° ≤ stem anteversion ≤10°; a CA:Widmer with 20° of stem anteversion; a CA of 40° or Widmer with 30° of stem anteversion. When stem anteversion is ≥40°, CA should be decided by each patient's state. Among them, a stem anteversion of 20° with cup anteversion of 23.3° was found to be the best CA pattern.

The influence of stem sagittal alignment on clinical outcomes is unclear in total hip arthroplasty (THA). The purpose of this study is to assess the relationship between stem sagittal alignment and clinical and radiographic outcomes using 3D-CT. We performed 370 consecutive primary THAs between 2009 and 2013. After exclusion, 102 hips in 89 patients using single tapered-wedge stem were included. Mean follow-up was 4.7 years. Stem sagittal alignment was measured using CT, and patients were divided into flexion and neutral alignment groups. Clinical and radiographic outcomes were compared between two groups. Furthermore, we evaluated the anterior femoral offset and initial contact state. There were no significant differences in clinical or radiographic outcomes between two groups. CT data analysis and multiple regression analysis showed flexion alignment increased anterior femoral offset (AFO) and Gruen zone 4 contact area. There was no significant difference in clinical or radiographic outcomes between flexion and neutral alignment of the tapered-wedge stem at an average of 4.7 years of follow-up. The increase of AFO and distal contact area in flexion alignment could affect the improvement of impingement-free range of flexion and intraoperative fracture.

Traditionally, Charcot arthropathy has been considered an absolute contraindication for total hip arthroplasty (THA). However, some recent reports have shown that good short- to mid-term results can be achieved by improving the durability of the implant. This paper reports the mid- to long-term results of THA in two patients with Charcot hip joints caused by congenital insensivity to pain with anhydrosis. Both patients suffered multiple posterior dislocations in the six months immediately following surgery. However, with the continuous use of a hard abduction brace, one patient was eventually able to walk with a lofstrand cane and the other with the use of one crutch. Although one patient experienced a dislocation five years after surgery, X-rays taken after nine years and five years, respectively, revealed no clinical signs of implant loosening. We conclude that, with careful planning and appropriate precautions, THA may be a viable treatment option for Charcot hip joints caused by congenital insensivity to pain with anhydrosis.

This study investigated the mid- and long-term results of acetabular reconstruction using a KT plate with an allograft and showed the utility of filling the bony defect with bulk femoral head allograft rather than morselised allograft. We retrospectively investigated a consecutive series of 31 hips in 30 patients who underwent primary THA or revision THA between March 2002 and March 2012. Bulk grafts from femoral head allografts were used in 16 hips and morselised grafts were used in 15 hips. The mean follow-up period was 7.2 years (3–13 years). The acetabular bone defects were classified according to the American Academy of Orthopedic Surgeons grading system. Type II defects were present in five hips; 26 hips were type III. Radiological failure, defined as absolute error of the inclination of the KT plate >3°, breakage of the KT plate or screw, and/or absolute error of the vertical or horizontal migration of the femoral head >3 mm was found in 12 cases. All these complications appeared in the morselized group; there were no complications in the bulk group. The eight-year survival rate of morselised grafts was 52.5 % and that of bulk grafts was 100 %, using radiological loosening as an end point. We conclude that using bulk graft from femoral head allografts is necessary to achieve mechanically stable reconstruction for large acetabular bone defects.

Purpose During total knee arthroplasty, few rotating reference axes can be reliably used after tibial resection. We speculated that a line that passes through the lateral edge of the posterior cruciate ligament (PCL) at its tibial attachment after resection and the most prominent point of the tibial tubercle [after-tibial resection (ATR) line] will provide a good reference axis. In this study, we aimed to evaluate the association between ATR and Akagi’s lines. Materials and methods In this case–control simulation study, we retrospectively evaluated 38 patients with varus knee and 28 patients with valgus knee. We defined the reference cutting plane as 10 mm distal from the lateral articular surface of the tibia in varus group and as 7 mm distal from the medial articular surface in the valgus group. We measured angles between Akagi’s line and the ATR line (ATR line angle) as well as between Akagi’s line and 1/3 Akagi’s line (1/3 Akagi’s line angle), which passes through the midpoint of PCL and the medial third of the patellar tendon. We used paired t-tests to determine the significance of differences between these angles, with p < 0.05 indicating statistical significance. Intra- and interclass correlation coefficients for the reproducibility of 1/3 Akagi’s line angle and ATR line angle were analyzed by two surgeons. Results We found that 1/3 Akagi’s line angle was 10.2° ± 1.3° in the varus group and 10.9° ± 1.3° in the valgus group (p = 0.017). The ATR line was positioned externally compared with Akagi’s line in all patients. Mean ATR line angles at 0°, 3° and 7° posterior slopes were 6.1° ± 1.9°, 5.8° ± 2.0° and 6.0° ± 1.7° in the varus group and 6.3° ± 2.3°, 6.2° ± 2.3° and 5.4° ± 2.1° in the valgus group, respectively. There were no significant differences in the ATR line angle between the varus and valgus groups. (p = 0.34–0.67) Intra- and interclass correlation coefficients for the reproducibility of 1/3 Akagi’s line angle were 0.936 and 0.986 and those for the reproducibility of ATR line angle were 0.811 and 0.839. Conclusions The ATR line was positioned between Akagi’s line and 1/3 Akagi’s line in all patients and was a valid option for evaluating rotational tibial alignment after tibial resection.

Medial collateral ligament (MCL) pie-crusting technique in total knee arthroplasty (TKA) is one of the methods of medial release. The effects and risks of blade pie-crusting have been reported in previous studies. However, only a few have reported the safety and efficacy of needle pie-crusting. In this cadaveric study, we quantitatively evaluated the amount of gap change by MCL needle pie-crusting. We investigated five knees of four fresh human cadavers and performed posterior-stabilized TKA. Only deep MCL release as the medial release was conducted. We punctured the MCL from the deep layer to the superficial layer using a 18 G needle in a 90-degree flexion position for 0, 10, 20, 50, 75, and 100 times. Medial and lateral gaps were measured accurately with a balancer at determined times in 0 and 90-degree flexion positions. Changes in medial and lateral gaps were not significant differences in flexion and extension position. However, in 90-degree flexion, medial gap changes were tended to be larger than lateral gap changes. A 0.6 mm additional medial release and a 0.2 mm additional lateral release were found per 10 times pie crust in flexion position (100 times, p: 0.08). However, large differences existed among the cases. Needle pie-crusting is safer than blade pie-crusting because of the small efficacy of one-time pie crust. MCL needle pie-crusting showed varied effects for each case. This result indicates the risk of relaxation of an unexpected gap. Caution should be taken when choosing between needle pie-crusting and blade pie-crusting.

The "grand-piano sign" is a well-known indicator of proper rotational femoral alignment. We investigated changes in the shape of the femoral anterior cutting plane by changing the rotational alignment, anterior portion depth, and cutting plane flexion angle.We simulated various cutting planes after cutting the anterior portion of the femur next to the distal femoral osteotomy in 50 patients with varus knee and also a femoral anterior osteotomy with four degree (S group) and seven degree (T group) flexion angles regarding the mechanical axis. We defined the final cutting plane as the farthest position that we could reach without making a notch and the precutting plane as two millimeters anterior from the final cutting plane. The simulated resection plane was rotated to produce external and internal rotation angles of 0°, three degrees, and five degrees relative to the surgical transepicondylar axis (SEA). We investigated medial and lateral portions of the femoral anterior cutting plane length ratio (M/L).When we cut parallel to SEA, M/L was 0.67±0.09 and 0.62±0.12 in the T and S groups, respectively. M/L was approximately 0.8 and 0.5 with five degree internal and external rotations, respectively (P0.01). On comparing final cutting and precutting planes, there were no significant differences in M/L without five degree external rotation in the T group and no significant difference in any case in the S group (P0.01).The ideal M/L of the femoral anterior cutting plane was 0.62-0.67. M/L did not change with a precutting plane in almost all rotational patterns.

We investigated the various impingement angles (including both bony and prosthetic impingement) and impingement types that can occur after THA, even when the same combined anteversion parameter is used. We also investigated the relationship between impingement angle and acetabular morphology or femoral anteversion. We evaluated 83 patients with no hip arthritis. We divided them into six groups according to acetabular CE angle (≤15°, >15–≤25°, and >25°) and femoral anteversion (≤20° and >20°). Using three-dimensional templating software, we changed stem and cup anteversion to satisfy a combined anteversion (CA) of 50° in each hip (stem anteversion + cup anteversion = 50°) and investigated the resulting impingement angles. Even with the same CA, differences in impingement angle occurred: 18.3° ± 7.2° with flexion, 30.2° ± 9.7° with internal rotation at 90° flexion, 20.2° ± 12.5° with extension, and 26.2° ± 7.8° with external rotation. As stem anteversion increased, the impingement type changed from prosthetic impingement to bony impingement in flexion and internal rotation and from bony impingement to prosthetic impingement in extension and external rotation. The flexion angle and internal rotation angle at 90° flexion increased (p

In TKA, we have used the "projected SEA", which is obtained by projecting the "true SEA" on the distal femoral cutting plane in clinical practice to determine the femoral component rotation. There are no reports examining the accuracy of the "projected SEA". In this study, we investigated the difference between the "true SEA" and "projected SEA".The present study was a CT-based computer-simulated case series. We evaluated 34 knees without osteoarthritis changes. These patients were selected from the operative schedule prior to THA. We defined the "true SEA" on the 3D model and the "projected SEA" on the cutting plane parallel to the distal femoral axis obtained based on the "true SEA". We changed the cutting angles from 20° flexion to 20° extension, and from five degrees varus to five degrees valgus. We measured the "true SEA angle" and "projected SEA angle" regarding the posterior condylar axis (PCA).The mean "true SEA angle" was 3.04°±1.34° (0.6-5.0°). The mean "projected SEA angle" was 3.43°±1.58° at 20° flexion, 3.42°±1.56° at 0° flexion, 3.43°±1.52° at 20° extension, 3.39°±1.59° at five degrees valgus, and 3.39°±1.50° at five degrees varus. At each cutting angle, the "projected SEA angle" was significantly larger than the "true SEA angle" (p0.001). There was no significant difference between any of the "projected SEA angles" (p0.001).We found that the true SEA and projected SEA do not differ significantly (0.39°±0.29° [range 0-1.0°]).

Background The surgical depths of approaches for total hip arthroplasty (THA) have not been reported previously. In this study, we investigate the relationships between the distances to the centre of the femoral head in different approaches and body mass index (BMI). Methods The study included patients with normal hip joints who presented to our hospital. We used the pelvic coordinate system relative to the anterior pelvic plane and the femur coordinate system relative to the posterior condylar plane. We assessed the anterior, anterolateral, lateral and posterior approaches, and defined each approach line. We evaluated each distance in terms of BMI and gender. Results 164 hips were assessed. The distance to the centre of the femoral head was the longest in the posterior approach, followed by the lateral, anterolateral, and anterior approaches (pConclusions The distance to the centre of the femoral head is the shortest in the anterior approach, regardless of BMI and gender. The distance in each approach might increase with an increase in BMI. BMI has similar effects in all approaches.

Initial fixation is a key factor in the success of cementless THA using a tapered wedge stem. The purpose of this study was to use three-dimensional templating software to examine the correlation between quantitative contact state and important clinical radiological outcomes, specifically stem subsidence, stress shielding, and cortical hypertrophy. We conducted a retrospective consecutive review of 75 hips in 70 patients over a minimum 3-year follow-up period. X-rays and CT scans were investigated to assess preoperative planning, quantify the contact state of implant and femur, and assess stem alignment, stem subsidence, stress shielding, and cortical hypertrophy. We evaluated the correlation between radiological outcomes and three-dimensional quantitative contact state according to Gruen Zone in each Dorr classification. Density mapping indicated that stem subsidence increased postoperatively if the stem had less cortical contact in the middle to distal portion of the implant in terms of initial fixation. Cases having too much cortical contact in the distal portion of the implant tended to have increased stress shielding. We found no correlation between cortical hypertrophy and the contact state of implant and femur. Density mapping with three-dimensional templating software can be useful in predicting stem subsidence and stress shielding following cementless THA with a tapered wedge stem. Further analysis is required to accurately depict the correlation between cortical hypertrophy and the contact state.

The loads and sources of heavy metals (Cd, Co, Cu, Mn, Mo, Ni, Pb, V, and Zn) in the midstream of Tama River were evaluated on the basis of their chemical analyses in ordinary and stormwater runoff from July 2007 to November 2008. Tama River is one of the three major rivers flowing into Tokyo Bay. The total annual water discharges differed largely for 2007 and 2008, depending on the scales of typhoon rainfalls and other heavy rainfalls in each year. The concentrations of the metals other than Mo in the river did not change markedly at a flow rate of less than approximately 200 m3 s−1, but at higher flow rates, the concentrations of all the metals increased linearly with the increase in the log of flow rate (r 2 = 0.94–0.99). The annual loads of heavy metals for 2007 and 2008 were estimated using regression equations between the above parameters and the hourly flow rate data for each year. For the metals other than Mo, the contribution of the loads at higher flow rates (>200 m3 s−1) was much larger than that at lower flow rates (

The annual wet and dry deposition fluxes of As, Cd, Cr, Cu, Hg, Mn, Ni, Pb and V were measured on the basis of data obtained from 2 years of observation (December 2003–November 2005) at three sites in the Tokyo Bay area, which is highly affected by anthropogenic sources. Moreover, the concentrations of these trace elements in the air and bay sediments were determined concurrently. Using these data, we evaluated the factors affecting wet and dry deposition fluxes and the contribution of the atmospheric input of each element to the supply of trace elements to the bay. The order of the average ratios of dry/wet deposition fluxes at three sites was Cr, 6.9>As, 5.9>Mn, 4.7>V, 4.5>Cu, 4.4>Ni, 3.7>Cd, 2.9>Pb, 2.0>Hg, 1.0. Thus, the atmospheric deposition of the trace elements except Hg in Tokyo Bay is predominantly dry deposition. For such trace elements, the wet and dry deposition fluxes within the bay were higher than those inland. Except in the case of some elements, the differences in wet and dry deposition fluxes between these sites were primarily due to the differences in scavenging ratio (=concentration in precipitation/concentration in air) and dry deposition velocity (=deposition flux/concentration in air), respectively, rather than in atmospheric concentration. Also, a significant correlation (r2=0.76, P

We developed a new povidone iodine coating technology for titanium hip implants and performed a clinical trial to assess its usefulness in suppressing postoperative infection. Results indicate that iodine-supported titanium has favorable antibacterial activity, biocompatibility, and no cytotoxicity. Thirty joints in 28 patients were treated using iodine-supported implants. Fourteen joints were revision total hip arthroplasty (THA) after periprosthetic infection, 13 were primary THA for immunosuppressive conditions or pyogenic arthritis, and 3 were conversions from hemiarthroplasty to THA for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and C-reactive protein (CRP) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14–78). There were no signs of infection in any patient at the last follow-up. WBC and CRP levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any patient. Excellent bone ingrowth and ongrowth were found around prostheses. No cytotoxicity or adverse effects were detected. These results suggest that iodine-supported THA implants can be highly effective in preventing and treating postoperative infections.