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2. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

3. Prospective multicenter study of the efficacy and safety of cold forceps polypectomy for ≤ 6-mm non-ampullary duodenal low-grade adenomas

Author

Kanzaki, Hiromitsu, additional, Horii, Joichiro, additional, Takenaka, Ryuta, additional, Nakagawa, Hiroyuki, additional, Matsueda, Kazuhiro, additional, Tsuzuki, Takao, additional, Kita, Masahide, additional, Yamasaki, Yasushi, additional, Tanaka, Takehiro, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Tomoda, Jun, additional, and Okada, Hiroyuki, additional

Published
2022
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13. Abstracts of selected papers presented at the 33rd annual meeting of the japanese society of gastroenterology

Author

Fujii, Daigo, Suyama, Masafumi, Sugiyama, Masanori, Atomi, Yutaka, Inui, Kazuo, Nakazawa, Saburo, Nakajima, Kimihiro, Katoh, Hiroyuki, Kaneda, Makoto, Ogura, Yoshifumi, Eto, Toshifumi, Tsunoda, Tsukasa, Uchimura, Masayuki, Narita, Kazuyuki, Sugioka, Atsushi, Tsuzuki, Toshiharu, Kanemitsu, Keiichiro, Tashiro, Seiki, Yoshikawa, Tatsuya, Hanyu, Fujio, Kondo, Satoshi, Nimura, Yuji, Eriguchi, Naofumi, Nakayama, Toshimichi, Mitake, Masahiro, Naitoh, Yasuo, Isawa, T., Okamoto, A., Miyazaki, Hiroshi, Ogata, Yoshirou, Kuno, Nobuyoshi, Kurimoto, Kumiko, Noguchi, Tohru, Makuuchi, Masatoshi, Ikari, Takaaki, Ariyama, Joe, Takao, Sonshin, Shimazu, Hisaaki, Kobari, Masao, Matsuno, Seiki, Tanigawa, K., Mizumoto, R., Nakasako, T., Hanyu, F., Saito, Naoyuki, Hiraoka, Takehisa, Ishikawa, Osamu, Imaoka, Shingi, Miyazaki, Naoyuki, Saitoh, Yoichi, Harada, Akio, Takagi, Hiroshi, Kawai, Y., Yamamoto, S., Nakanishi, Ryo, Beppu, Tomoe, Okushiba, Shunichi, Katoh, Hiroyuki, Sakamoto, Hiroaki, Obara, Katsutoshi, Toba, Masahito, Onda, Masahiko, Azuma, Masayoshi, Kashiwagi, Toru, Sumino, Michihiro, Toyonaga, Atsushi, Hagiwara, Masaru, Sakai, Masahiro, Kokubu, Shigehiro, Shibata, Hisao, Miyoshi, Hirofumi, Orino, Shinya, Yoshida, Tomoharu, Itoh, Tadahiko, Murashima, Naoya, Matsumura, Masahiko, Tsujii, Tadasu, Murayama, Takashi, Tameda, Yukihiko, Matsutani, Shoichi, Ishii, Hiroshi, Mitarai, Yoshinobu, Kobayashi, Michio, Nishida, Hitoshi, Kawada, Taiji, Matsuda, Hiroko, Kawasaki, Tsunehisa, Arakawa, Tetsuo, Kobayashi, Kenzo, Ota, Shinichi, Terano, Akira, Nakamura, Masahiko, Oda, Masaya, Tari, Akira, Yamamoto, Goso, Saito, Eiichi, Matsuo, Yutaka, Mizuno, Motowo, Tomoda, Jun, Asada, Shuji, Takiuchi, Hiroya, Mogi, Mizuhiro, Kitajima, Masaki, Nagano, Kouichi, Sato, Nobuhiro, Naito, Yuji, Yoshikawa, Toshikazu, Asaka, Masahiro, Sato, Yasuo, Iwafuchi, Mitsuya, Watanabe, Hidenobu, Yoshida, Yukio, Kihira, Ken, Kashiwagi, Hideyuki, Aoki, Teruaki, Nishikawa, Masahiro, Suzuki, Takashi, Matsui, Toshiyuki, Iida, Mitsuo, Katoh, H., Munakata, A., Itsuno, Minoru, Makiyama, Kazuya, Hibi, Toshifumi, Kitahora, Tetsuji, Igarashi, Masahiro, Katsumata, Tomoe, Satomi, Masamichi, Yamamura, Makoto, Hirata, Ichiro, Slezak, Premysl, Kubota, Yoshiro, Muto, Tetsuichiro, Morise, Kimitomo, Kusugami, Kazuo, Sugita, Akira, Fukushima, Tsuneo, Okada, Mitsuo, Sakurai, Toshihiro, Iida, Mitsuo, Kawasaki, Atsushi, Hiwatashi, Nobuo, Yamazaki, Hideo, Oriishi, Tetsuharu, Sasaki, Ei, Takazoe, Masakazu, Inoue, Noboru, Funayama, Y., and Matsuno, S.

Published
1993
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15. Mo1174 CLINICOPATHOLOGICAL CHARACTERISTICS AND RISK FACTORS FOR METASTASIS OF SUPERFICIAL BARRETT'S ADENOCARCINOMA:A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY

Author

Mouri, Hirokazu, primary, Mizuno, Motowo, additional, Hamada, Kenta, additional, Kanzaki, Hiromitsu, additional, Okada, Hiroyuki, additional, Takahashi, Sakuma, additional, Nasu, Junichiro, additional, Miyaike, Jiro, additional, Yamauchi, Kenji, additional, Takenaka, Ryuta, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Inoue, Masafumi, additional, Nishimura, Mamoru, additional, Matubara, Minoru, additional, and Tomoda, Jun, additional

Published
2019
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16. Su1251 – Clinicopathological Features of Sporadic Non-Ampullary Duodenal Adenoma and Carcinoma: A Multicenter Retrospective Observational Study

Author

Matsueda, Katsunori, primary, Kanzaki, Hiromitsu, additional, Matsueda, Kazuhiro, additional, Nasu, Junichiro, additional, Yoshioka, Masao, additional, Nakagawa, Masahiro, additional, Inoue, Masafumi, additional, Inaba, Tomoki, additional, Imagawa, Atsushi, additional, Takatani, Masahiro, additional, Takenaka, Ryuta, additional, Suzuki, Seiyu, additional, Tomoda, Jun, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2019
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17. The clinicopathological differences of sporadic non‐ampullary duodenal epithelial neoplasm depending on tumor location

Author

Matsueda, Katsunori, primary, Kanzaki, Hiromitsu, additional, Matsueda, Kazuhiro, additional, Nasu, Junichiro, additional, Yoshioka, Masao, additional, Nakagawa, Masahiro, additional, Inoue, Masafumi, additional, Inaba, Tomoki, additional, Imagawa, Atsushi, additional, Takatani, Masahiro, additional, Takenaka, Ryuta, additional, Suzuki, Seiyu, additional, Tomoda, Jun, additional, Yagi, Takahito, additional, Fujiwara, Toshiyoshi, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2019
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21. Risk factors for non-curative resection of early gastric neoplasms with endoscopic submucosal dissection: Analysis of 1,123 lesions

Author

TOYOKAWA, TATSUYA, primary, INABA, TOMOKI, additional, OMOTE, SHIZUMA, additional, OKAMOTO, AKIKO, additional, MIYASAKA, RIKA, additional, WATANABE, KAZUO, additional, IZUMIKAWA, KOICHI, additional, FUJITA, ISAO, additional, HORII, JOICHIRO, additional, ISHIKAWA, SHIGENAO, additional, MORIKAWA, TAMIYA, additional, MURAKAMI, TAKAKO, additional, and TOMODA, JUN, additional

Published
2015
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22. Prospective evaluation of endoscopic criteria characteristic of sessile serrated adenomas/polyps

Author

Uraoka, Toshio, primary, Higashi, Reiji, additional, Horii, Joichiro, additional, Harada, Keita, additional, Hori, Keisuke, additional, Okada, Hiroyuki, additional, Mizuno, Motowo, additional, Tomoda, Jun, additional, Ohara, Nobuya, additional, Tanaka, Takehiro, additional, Chiu, Han-Mo, additional, Yahagi, Naohisa, additional, and Yamamoto, Kazuhide, additional

Published
2014
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25. Mesalazine suppositories and their clinical application

Author

Funagakure, Keiko, primary, Horita, Syuzi, additional, Hamaoka, Terutaka, additional, Tasaka, Takeshi, additional, Tatibana, Hiroshi, additional, Murakami, Takako, additional, Toyokawa, Tatuya, additional, Sato, Eiji, additional, and Tomoda, Jun, additional

Published
2013
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34. A surgical case of phlegmonous gastritis after endoscopic submucosal dissection for early gastric cancer

Author

Nishie, Manabu, primary, Iwakawa, Kazuhide, additional, Hamano, Ryousuke, additional, Tokunaga, Naoyuki, additional, Tunemitsu, Yousuke, additional, Ootsuka, Shinya, additional, Inagaki, Masaru, additional, Iwagaki, Hiromi, additional, Goubaru, Tomohiro, additional, Fujita, Isao, additional, Murakami, Takako, additional, and Tomoda, Jun, additional

Published
2011
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35. Immunohistochemical analysis of epithelial cell proliferation in normal-appearing rectal mucosa of patients with colorectal adenoma and cancer using an in vitro labeling method with bromodeoxyuridine

Author

Ikeda, Nobumasa, Mizuno, Motowo, Okada, Hiroyuki, Tomoda, Jun, and Tsuji, Takao

Subjects
Adenoma, Adult, Male, Rectum, Middle Aged, Immunohistochemistry, colon cancer, Bromodeoxyuridine, Humans, Female, Intestinal Mucosa, Colorectal Neoplasms, Cell Division, Aged
Abstract

To identify diffuse mucosal changes which may precede the development of colorectal cancer and a possible indicator for detecting high-risk populations, we immunohistochemically studied cell-cycle events in crypts of normal-appearing rectal mucosa of patients with colorectal adenoma and cancer using an in vitro labeling method with bromodeoxyuridine (BrdU). Biopsy specimens of endoscopically normal-appearing rectal mucosa were obtained during colonoscopy from 20 patients with colorectal adenocarcinoma, 20 with adenoma, and 15 without apparent colorectal diseases. The specimens were incubated with BrdU in vitro, and labeled S-phase cells were identified immunohistochemically using a monoclonal antibody to BrdU. Modification of the BrdU-labeling pattern in the normal appearing rectal mucosa, such as the presence of BrdU-labeled cells at the mucosal surface or in the upper one-fifth of the crypt column, was observed in 15 of the 20 patients with adenocarcinoma, 17 of the 20 patients with adenoma and 6 of the 15 controls. This upward shift in the frequency of proliferating cells in the crypt was significantly higher in the patients with colorectal adenoma and cancer than in the controls, and may be used to identify subjects at high risk for colorectal cancer.

Published
1994

36. Endoscopical segmental piecemeal tumorectomy for nodular elevation of colorectal tumor: applicability and patient's quality of life

Author

Ariki, Norifumi, Iwagaki, Hiromi, Yoshino, Tadashi, Nonaka, Yasuyuki, Fujiki, Shigeatsu, Perdomo, Jose Antonio, Hizuta, Akio, Tomoda, Jun, Tanaka, Noriaki, Tsuji, Takao, and Orita, Kunzo

Subjects
Male, nodular elevation, Humans, Female, coloretal tumors, Colonoscopy, Middle Aged, Colorectal Neoplasms, endoscopical segmental piecemeal tumorectomy, Aged
Abstract

Endoscopical segmental piecemeal tumorectomy (ESPT) for nodular elevation of colorectal tumor is advantageous in terms of minimizing both surgical invasion and postoperative burden to the patients. Nodular elevation of colorectal tumors is said to occur when the body of the tumor is adenomatous and the surface of the focal cancer grows more horizontally into the lumen than vertically. We report here four cases of nodular elevation of colorectal tumors which were each treated by different surgical procedures.

Published
1994

42. Analysis of galactosyltransferase activity in rat gastric mucosa using crude mucosal homogenate

Author

Hongo, Toshiki, Tomoda, Jun, Mizuno, Motowo, Maga, Toshirou, and Tsuji, Takao

Subjects
rat gastric mucosa, Male, UDP-galactosyltransferase, ovomucoid, Gastric Mucosa, Animals, Rats, Inbred Strains, asialomucin, Galactosyltransferases, Rats
Abstract

Mucus glycoprotein is one of the major components of gastric mucus which plays an important role in mucosal defensive mechanisms as a mucus-bicarbonate barrier. Analysis of the mucus glycoprotein synthesis is a useful tool for evaluating gastric mucosal defensive factors. UDP-galactosyltransferase (UDP-Gal-T) is one of the regulating enzymes for the synthesis of the mucus glycoprotein. In the present paper, we studied assay methods for UDP-Gal-T activity in rat gastric mucosa using radiolabeled UDP-galactose and two different kinds of acceptor proteins, namely ovomucoid and asialomucin, and analyzed effects of antisecretory agents on the UDP-Gal-T activity. We used crude supernatants of homogenized scrapings of the fundic part of rat stomach as an enzyme preparation and determined optimal conditions. In each acceptor, Mn2+ and the non-ionic detergent Triton X-100 were required for the enzyme activity. With each acceptor molecule, the type of glycosidic linkages of galactose was beta-type linkage. With asialomucin as an acceptor, UDP-Gal-T activities of rat gastric mucosa decreased after intraperitoneal administration of antisecretory agents, while change of the enzyme activity was not observed with ovomucoid as an acceptor.

Published
1991

43. A Case of Intractable Hepatic Hydrothorax treated by Pleuro-Venous Shunt

Author

INAGAKI, Masaru, primary, TANABE, Syunsuke, additional, YOSHIDA, Ryousuke, additional, ARIKI, Norifumi, additional, TSUNEMITSU, Yousuke, additional, OTSUKA, Shinya, additional, MIYOSHI, Kazuya, additional, OSAKI, Toshihide, additional, FUCHIMOTO, Sadanori, additional, YUMURA, Masahito, additional, HORI, Keisuke, additional, and TOMODA, Jun, additional

Published
2005
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44. Assessment of UDP-Galactosyl- transf erase Activity in Gastric Mucosa of Patients with Chronic Liver Disease Using an Enzyme-Linked Peanut Agglutinin Binding Assay

Author

Maga, Toshirou, primary, Mizuno, Motowo, additional, Tanaka, Shouichi, additional, Yoshinaga, Fumiya, additional, Mikami, Yuichirou, additional, Kihara, Yasuhiro, additional, Kiso, Takahiko, additional, Tomoda, Jun, additional, Okada, Hiroyuki, additional, and Tsuji, Takao, additional

Published
1997
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