224 results on '"Tomlinson, I. P. M."'
Search Results
2. Whole-Gene APC Deletions Cause Classical Familial Adenomatous Polyposis, but not Attenuated Polyposis or "Multiple" Colorectal Adenomas
3. SMAD4 Mutations in Colorectal Cancer Probably Occur before Chromosomal Instability, but after Divergence of the Microsatellite Instability Pathway
4. APC Mutations in Sporadic Colorectal Tumors: A Mutational "Hotspot" and Interdependence of the "Two Hits"
5. Mechanisms of Inactivation of Mismatch Repair Genes in Human Colorectal Cancer Cell Lines: The Predominant Role of hMLH1
6. β -Catenin Mutations in Cell Lines Established from Human Colorectal Cancers
7. The Mutation Rate and Cancer
8. Polyclonal Origin of Colonic Adenomas in an XO/XY Patient with FAP
9. Exploring the association between Body Mass Index, Sex and Gene Expression in human colorectal epithelium
10. Failure of Programmed Cell Death and Differentiation as Causes of Tumors: Some Simple Mathematical Models
11. Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia
12. Location in the large bowel influences the APC mutations observed in FAP adenomas
13. APC and the three-hit hypothesis
14. Physical Activity Reduces Colorectal Cancer Risk Independent of BMI:A Mendelian Randomisation Study
15. Exon 3 betacatenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome
16. Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene?
17. TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres
18. Whole genome copy number & LoH analysis of colorectal cancers reveals extensive intra-tumoural heterogeneity: Cancer/Surgical Oncology (GI) 0013
19. The role of cell proliferation and crypt fission in adenoma aggressiveness: a comparison of ileoanal pouch and rectal adenomas in familial adenomatous polyposis
20. Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria
21. A study of nonrandom mating in a British population of the two-spot ladybird with a high frequency of the melanic morph
22. Nonrandom mating in the two-spot ladybird (Adalia bipunctata): The influence of weight on mating success
23. Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation
24. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome
25. Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families
26. Exon 3 β-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome
27. Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation
28. Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases
29. Germline mutations in the TGF-[beta] and Wnt signalling pathways are a rare cause of the “multiple” adenoma phenotype
30. Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes
31. Molecular characteristics of serrated adenomas of the colorectum
32. The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas
33. Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age
34. Molecular pathology of solid tumours: some practical suggestions for translating research into clinical practice
35. Two hits revisited again
36. Analysis of genetic and phenotypic heterogeneity in juvenile polyposis
37. Detecting low penetrance genes in cancer: the way ahead
38. Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients
39. Clinical features and molecular analysis of a family with multiple colon tumours and reduced plasminogen activator activity
40. Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer
41. Peutz-Jeghers syndrome
42. Genetic prognostic markers in colorectal cancer
43. Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas
44. Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers
45. Tumour recurrence is associated with Jass grouping but not with differences in E-cadherin expression in moderately differentiated Dukes' B colorectal cancers
46. Genetic Testing is Important in Families with A History Suggestive of Hereditary Non-Polyposis Colorectal Cancer Even if the Amsterdam Criteria are not Fulfilled
47. Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer
48. The influence of female viability differences on the evolution of mate choice
49. Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis
50. A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36
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