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1. Glasdegib plus intensive or non-intensive chemotherapy for untreated acute myeloid leukemia: results from the randomized, phase 3 BRIGHT AML 1019 trial.

Author

Tomlinson, Benjamin, Mayer, Jiri, Jou, Erin, Robak, Tadeusz, Taussig, David, Dombret, Hervé, Merchant, Akil, Shaik, Naveed, OBrien, Thomas, Roh, Whijae, Liu, Xueli, Ma, Wendy, DiRienzo, Christine, Chan, Geoffrey, Cortes, Jorge, Sekeres, Mikkael, Montesinos, Pau, Novak, Jan, Wang, Jianxiang, and Jeyakumar, Deepa

Abstract

This is the primary report of the randomized, placebo-controlled phase 3 BRIGHT AML 1019 clinical trial of glasdegib in combination with intensive chemotherapy (cytarabine and daunorubicin) or non-intensive chemotherapy (azacitidine) in patients with untreated acute myeloid leukemia. Overall survival (primary endpoint) was similar between the glasdegib and placebo arms in the intensive (n = 404; hazard ratio [HR] 1.05; 95% confidence interval [CI]: 0.782-1.408; two-sided p = 0.749) and non-intensive (n = 325; HR 0.99; 95% CI: 0.768-1.289; two-sided p = 0.969) studies. The proportion of patients who experienced treatment-emergent adverse events was similar for glasdegib versus placebo (intensive: 99.0% vs. 98.5%; non-intensive: 99.4% vs. 98.8%). The most common treatment-emergent adverse events were nausea, febrile neutropenia, and anemia in the intensive study and anemia, constipation, and nausea in the non-intensive study. The addition of glasdegib to either cytarabine and daunorubicin or azacitidine did not significantly improve overall survival and the primary efficacy endpoint for the BRIGHT AML 1019 phase 3 trial was not met. Clinical trial registration: ClinicalTrials.gov: NCT03416179.

Published
2023

3. Glasdegib plus intensive or non-intensive chemotherapy for untreated acute myeloid leukemia: results from the randomized, phase 3 BRIGHT AML 1019 trial

Author

Sekeres, Mikkael A., Montesinos, Pau, Novak, Jan, Wang, Jianxiang, Jeyakumar, Deepa, Tomlinson, Benjamin, Mayer, Jiri, Jou, Erin, Robak, Tadeusz, Taussig, David C., Dombret, Hervé, Merchant, Akil, Shaik, Naveed, O’Brien, Thomas, Roh, Whijae, Liu, Xueli, Ma, Wendy, DiRienzo, Christine G., Chan, Geoffrey, and Cortes, Jorge E.

Published
2023
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5. A multicenter study of posttransplantation low-dose inotuzumab ozogamicin to prevent relapse of acute lymphoblastic leukemia

Author

Metheny, Leland L., Sobecks, Ronald, Cho, Christina, Fu, Pingfu, Margevicius, Seunghee, Wang, Jiasheng, Ciarrone, Lisa, Kopp, Shelby, Convents, Robin D., Majhail, Navneet, Caimi, Paolo F., Otegbeye, Folashade, Cooper, Brenda W., Gallogly, Molly, Malek, Ehsan, Tomlinson, Benjamin, Gerds, Aaron T., Hamilton, Betty, Giralt, Sergio, Perales, Miguel-Angel, and de Lima, Marcos

Published
2024
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8. Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

Author

Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, null, null, Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, and null, null

Abstract

PURPOSEAllogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of FLT3 (FLT3-ITD) AML. These patients are routinely treated with a FLT3 inhibitor after HCT, but there is limited evidence to support this. Accordingly, we conducted a randomized trial of post-HCT maintenance with the FLT3 inhibitor gilteritinib (ClinicalTrials.gov identifier: NCT02997202) to determine if all such patients benefit or if detection of measurable residual disease (MRD) could identify those who might benefit.METHODSAdults with FLT3-ITD AML in first remission underwent HCT and were randomly assigned to placebo or 120 mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival (RFS). Secondary end points included overall survival (OS) and the effect of MRD pre- and post-HCT on RFS and OS.RESULTSThree hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided P =.0518). However, 50.5% of participants had MRD detectable pre- or post-HCT, and, in a prespecified subgroup analysis, gilteritinib was beneficial in this population (HR, 0.515 [95% CI, 0.316 to 0.838]; P =.0065). Those without detectable MRD showed no benefit (HR, 1.213 [95% CI, 0.616 to 2.387]; P =.575).CONCLUSIONAlthough the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable FLT3-ITD MRD pre- or post-HCT who received gilteritinib treatment. To our knowledge, these data are among the first to support the effectiveness of MRD-based post-HCT therapy.

Published
2024

13. 131I-Apamistamab Improves Outcomes in Patients 65 Years and Older with Relapsed or Refractory AML

Author

Nath, Rajneesh, primary, Seropian, Stuart, additional, Gyurkocza, Boglarka, additional, Choe, Hannah, additional, Litzow, Mark R., additional, Abboud, Camille, additional, Koshy, Nebu, additional, Stiff, Patrick J., additional, Abhyankar, Sunil H., additional, Foran, James, additional, Abedin, Sameem, additional, Chen, George L, additional, Al-Kadhimi, Zaid, additional, Kebriaei, Partow, additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Jamieson, Katarzyna, additional, Silverman, Margarida, additional, van Besien, Koen, additional, Schuster, Michael W, additional, Law, Arjun D., additional, Spross, Jennifer, additional, Li, Kate L, additional, Nagl, Norman G, additional, Vusirikala, Madhuri, additional, Nahar, Akash, additional, Desai, Avinash, additional, and Tomlinson, Benjamin, additional

Published
2024
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14. Targeted Myeloablative Radiation Using 131I-Apamistamab Prior to Allogeneic Hematopoietic Cell Transplant for Patients with R/R AML Results in Robust Engraftment

Author

Choe, Hannah, primary, Nath, Dr. Rajneesh, additional, Seropian, Dr. Stuart E., additional, Litzow, Mark R., additional, Abboud, Camille, additional, Koshy, Nebu, additional, Stiff, Patrick J., additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil H., additional, Foran, James, additional, Abedin, Sameem, additional, Chen, George L, additional, Al-Kadhimi, Zaid, additional, Kebriaei, Partow, additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Jamieson, Katarzyna, additional, Silverman, Margarida, additional, van Besien, Koen, additional, Schuster, Michael W, additional, Law, Arjun D., additional, Spross, Jennifer, additional, Li, Kate L, additional, Nagl, Norman G, additional, Vusirikala, Madhuri, additional, Nahar, Akash, additional, Desai, Avinash, additional, and Gyurkocza, Boglarka, additional

Published
2024
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15. 131I-Apamistamab-Led Allogeneic Hematopoietic Cell Transplant for Patients with TP53 Mutated R/R AML Results in Significantly Improved Outcomes

Author

Foran, James, primary, Gyurkocza, Boglarka, additional, Nath, Rajneesh, additional, Choe, Hannah, additional, Litzow, Mark R., additional, Abboud, Camille, additional, Koshy, Nebu, additional, Stiff, Patrick J., additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil H., additional, Abedin, Sameem, additional, Chen, George L, additional, Al-Kadhimi, Zaid, additional, Kebriaei, Partow, additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Jamieson, Katarzyna, additional, Magalhaes-Silverman, Margarida, additional, van Besien, Koen, additional, Schuster, Michael W, additional, Law, Arjun D., additional, Mayer, Sebastian, additional, Lazarus, Hillard M, additional, Spross, Jennifer, additional, Li, Kate L, additional, Nagl, Norman G, additional, Brodin, Patrik, additional, Vusirikala, Madhuri, additional, Nahar, Akash, additional, Sandmaier, Prof. Brenda M., additional, Pagel, John M., additional, Giralt, Sergio A., additional, Desai, Avinash, additional, and Seropian, Stuart, additional

Published
2024
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16. Dose-Response Demonstrated for Durable Complete Remission Following High-Dose Targeted Radiation with 131I-Apamistamab Prior to HCT in Patients with R/R AML

Author

Chen, George L, primary, Abboud, Camille, additional, Gyurkocza, Boglarka, additional, Nath, Rajneesh, additional, Seropian, Stuart, additional, Choe, Hannah, additional, Litzow, Mark R., additional, Koshy, Nebu, additional, Stiff, Patrick J., additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil H., additional, Foran, James, additional, Abedin, Sameem, additional, Al-Kadhimi, Zaid, additional, Kebriaei, Partow, additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Jamieson, Katarzyna, additional, Magalhaes-Silverman, Margarida, additional, van Besien, Koen, additional, Schuster, Michael W, additional, Law, Arjun D., additional, Leung, Eugene, additional, Chen, Ming-Kai, additional, Natwa, Mona P, additional, Spross, Jennifer, additional, Li, Kate L, additional, Desai, Avinash, additional, Wahl, Richard L, additional, Brodin, Patrik, additional, and Pandit-Taskar, Neeta, additional

Published
2024
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17. Transplantation Referral Patterns for Patients with Newly Diagnosed Higher-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia at Academic and Community Sites in the Connect® Myeloid Disease Registry: Potential Barriers to Care

Author

Tomlinson, Benjamin, de Lima, Marcos, Cogle, Christopher R., Thompson, Michael A., Grinblatt, David L., Pollyea, Daniel A., Komrokji, Rami S., Roboz, Gail J., Savona, Michael R., Sekeres, Mikkael A., Abedi, Mehrdad, Garcia-Manero, Guillermo, Kurtin, Sandra E., Maciejewski, Jaroslaw P., Patel, Jay L., Revicki, Dennis A., George, Tracy I., Flick, E. Dawn, Kiselev, Pavel, Louis, Chrystal U., DeGutis, Irene S., Nifenecker, Melissa, Erba, Harry P., Steensma, David P., and Scott, Bart L.

Published
2023
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18. Phase I Trial of Arginine Deprivation Therapy with ADI-PEG 20 Plus Docetaxel in Patients with Advanced Malignant Solid Tumors

Author

Tomlinson, Benjamin K, Thomson, James A, Bomalaski, John S, Diaz, Monica, Akande, Taiwo, Mahaffey, Nichole, Li, Tianhong, Dutia, Mrinal P, Kelly, Karen, Gong, I-Yeh, Semrad, Thomas, Gandara, David R, Pan, Chong-Xian, and Lara, Primo N

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Patient Safety, Cancer, Lung, Rare Diseases, Clinical Research, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Antineoplastic Combined Chemotherapy Protocols, Arginine, Docetaxel, Drug Administration Schedule, Drug-Related Side Effects and Adverse Reactions, Female, Humans, Hydrolases, Male, Neoplasm Staging, Neoplasms, Polyethylene Glycols, Taxoids, Treatment Outcome, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeThis phase I study examined the toxicity and tolerability of pegylated arginine deiminase (ADI-PEG 20) in combination with docetaxel in patients with advanced solid malignancies.Experimental designEligible patients had histologically proven advanced solid malignancies, with any number of prior therapies, Zubrod performance status 0-2, and adequate organ function. Patients received ADI-PEG 20 weekly intramuscular injection ranging from 4.5 to 36 mg/m(2) and up to 10 doses of docetaxel (75 mg/m(2)) every 3 weeks. Primary endpoints were safety, toxicity, and a recommended phase II dose. Circulating arginine levels were measured before each cycle. Tumor response was measured as a secondary endpoint every 6 weeks on study.ResultsEighteen patients received a total of 116 cycles of therapy through four dose levels of ADI-PEG 20. A single dose-limiting toxicity (grade 3 urticarial rash) was observed at the 1st dose level, with no additional dose-limiting toxicities observed. Hematologic toxicities were common with 14 patients experiencing at least one grade 3 to 4 leukopenia. Fatigue was the most prevalent toxicity reported by 16 patients. Arginine was variably suppressed with 10 patients achieving at least a 50% reduction in baseline values. In 14 patients with evaluable disease, four partial responses (including 2 patients with PSA response) were documented, and 7 patients had stable disease.ConclusionsADI-PEG 20 demonstrated reasonable toxicity in combination with docetaxel. Promising clinical activity was noted, and expansion cohorts are now accruing for both castrate-resistant prostate cancer and non-small cell lung cancer at a recommended phase II dose of 36 mg/m(2).

Published
2015

20. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author

Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, Mitra, Dipayan, Bhatnagar, Priya, du Plessis, Johannes, Joshi, Yogish, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Sprigg, Nikola, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dennis, Martin, Sudlow, Cathie, Whiteley, William, Al-Shahi Salman, Rustam, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Minks, David P, Rodrigues, Mark A, du Plessis, Johann C, Dennis, Martin S, Murray, Gordon D, Newby, David E, Sandercock, Peter A G, Stephen, Jacqueline, Sudlow, Cathie L M, Werring, David J, Whiteley, William N, Wardlaw, Joanna M, and White, Philip M

Published
2019
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21. Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia

Author

Covut, Fahrettin, Gupta, Divya, Pinto, Raisa, Dambrosio, Nina, El Jurdi, Najla, Meyerson, Howard, Ueda, Masumi, Kolk, Merle, Creger, Richard, Metheny, Leland, Cooper, Brenda W., Caimi, Paolo F., Malek, Ehsan, Otegbeye, Folashade, Lazarus, Hillard M., De Lima, Marcos, and Tomlinson, Benjamin K.

Published
2019
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22. POSTER: AML-521 The Randomized Phase III SIERRA (Study of Iomab-B in Elderly Relapsed or Refractory AML) Trial: Successful Allogeneic Hematopoietic Stem Cell Transplantation Using Treatment With Iomab-B-Led Regimen for Patients With Active, Relapsed or Refractory AML With Failed Targeted Therapies

Author

Nath, Rajneesh, primary, Seropian, Stuart, additional, Choe, Hannah, additional, Litzow, Mark R., additional, Abboud, Camille, additional, Koshy, Nebu, additional, Stiff, Patrick J., additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil, additional, Foran, James M., additional, Hari, Parameswaran, additional, Chen, George L., additional, Al-Kadhimi, Zaid S., additional, Kebriaei, Partow, additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Jamieson, Katarzyna, additional, Magalhaes-Silverman, Margarida, additional, Van Besien, Koen, additional, Schuster, Michael, additional, Law, Arjun, additional, Abedin, Sameem, additional, Larkin, Karilyn, additional, Rowley, Scott, additional, Munshi, Pashna, additional, Cook, Rachel, additional, Mayer, Sebastian, additional, Levy, Moshe Yair, additional, Lazarus, Hillard M., additional, Sandmaier, Brenda M., additional, Reddy, Vijay, additional, Spross, Jennifer, additional, McNamara, Kathleen, additional, Haeuber, Elaina, additional, Vusirikala, Madhuri, additional, Nahar, Akash, additional, Pagel, John M., additional, Giralt, Sergio A., additional, Desai, Avinash, additional, and Gyurkocza, Boglarka, additional

Published
2023
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23. AML-521 The Randomized Phase III SIERRA (Study of Iomab-B in Elderly Relapsed or Refractory AML) Trial: Successful Allogeneic Hematopoietic Stem Cell Transplantation Using Treatment With Iomab-B-Led Regimen for Patients With Active, Relapsed or Refractory AML With Failed Targeted Therapies

Author

Nath, Rajneesh, primary, Seropian, Stuart, additional, Choe, Hannah, additional, Litzow, Mark R., additional, Abboud, Camille, additional, Koshy, Nebu, additional, Stiff, Patrick J., additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil, additional, Foran, James M., additional, Hari, Parameswaran, additional, Chen, George L., additional, Al-Kadhimi, Zaid S., additional, Kebriaei, Partow, additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Jamieson, Katarzyna, additional, Magalhaes-Silverman, Margarida, additional, Van Besien, Koen, additional, Schuster, Michael, additional, Law, Arjun, additional, Abedin, Sameem, additional, Larkin, Karilyn, additional, Rowley, Scott, additional, Munshi, Pashna, additional, Cook, Rachel, additional, Mayer, Sebastian, additional, Levy, Moshe Yair, additional, Lazarus, Hillard M., additional, Sandmaier, Brenda M., additional, Reddy, Vijay, additional, Spross, Jennifer, additional, McNamara, Kathleen, additional, Haeuber, Elaina, additional, Vusirikala, Madhuri, additional, Nahar, Akash, additional, Pagel, John M., additional, Giralt, Sergio A., additional, Desai, Avinash, additional, and Gyurkocza, Boglarka, additional

Published
2023
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24. Targeted Marrow Irradiation Intensification of Reduced-Intensity Fludarabine/Busulfan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation

Author

Ali, Naveed, Sharma, Ashish Arunkumar, de Rezende, Ana Carolina Pires, Otegbeye, Folashade, Latif, Bilal Muhammad, Kerbauy, Mariana Nassif, Cooper, Brenda W., Sanchez, Gabriela, Metheny, Leland, Bal, Saswat K., Sakuraba, Roberto, Tomlinson, Benjamin K., Boughan, Kirsten M., Kerbauy, Lucila, Malek, Ehsan, Ribeiro, Andreza Feitosa, Gallogly, Molly, Mansur, David, Pereira, Gisele, Weltman, Eduardo, Sekaly, Rafick-Pierre, de Lima, Marcos, Caimi, Paolo F., and Hamerschlak, Nelson

Published
2022
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26. A Phase I Study to Determine the Maximum Tolerated Dose of ex Vivo Expanded Natural Killer Cells Derived from Unrelated, HLA-Disparate Adult Donors

Author

Otegbeye, Folashade, Cooper, Brenda, Caimi, Paolo, Zamborsky, Kayla, Reese-Koc, Jane, Hillian, Antoinette, Hernandez-Collazo, Yeritza, Lee, Grace, Boughan, Kirsten, Tomlinson, Benjamin, Gallogly, Molly, Metheny, Leland, Bajor, David, Selfridge, Jennifer, Saltzman, Joel, Lazarus, Hillard, de Lima, Marcos, and Wald, David

Published
2022
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27. S248: SIERRA TRIAL RESULTS WITH A TARGETED RADIOTHERAPY, IOMAB-B, A MYELOABLATIVE CONDITIONING WITH REDUCED INTENSITY TOLERABILITY YIELDS HIGH CR, LONG TERM SURVIVAL IN HSCT INELIGIBLE ACTIVE R/R AML

Author

Gyurkocza, Boglarka, primary, Seropian, Stuart, additional, Choe, Hannah, additional, Litzow, Mark, additional, Abboud, Camille, additional, Koshy, Nebu, additional, Stiff, Patrick, additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil, additional, Foran, James M, additional, Hari, Parameswaran, additional, Chen, George, additional, Al-Kadhimi, Zaid, additional, Kebriaei, Partow, additional, Sabloff, Mitchell, additional, Orozco, Johnnie, additional, Jamieson, Katarzyna, additional, Silverman, Margarida, additional, Van Besien, Koen, additional, Schuster, Michael, additional, Law, Arjun, additional, Abedin, Sameem, additional, Larkin, Karilyn, additional, Rowley, Scott, additional, Munshi, Pashna, additional, Cook, Rachel, additional, Mayer, Sebastian, additional, Levy, Moshe Yair, additional, Lazarus, Hillard, additional, Sandmaier, Brenda, additional, Reddy, Vijay, additional, Spross, Jennifer, additional, Mcnamara, Kathleen, additional, Haeuber, Elaina, additional, Vusirikala, Madhuri, additional, Nahar, Akash, additional, Pagel, John, additional, Giralt, Sergio, additional, Desai, Avinash, additional, and Nath, Rajneesh, additional

Published
2023
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28. P1396: CD33-DELETED HEMATOPOIETIC STEM AND PROGENITOR CELLS DISPLAY NORMAL ENGRAFTMENT AFTER HEMATOPOIETIC CELL TRANSPLANT (HCT) AND TOLERATE POST-HCT GEMTUZUMAB OZOGAMICIN (GO) WITHOUT CYTOPENIAS

Author

Koehne, Guenther, primary, Tomlinson, Benjamin, additional, Suh, Hyung, additional, Koura, Divya, additional, Cho, Christina, additional, Bambace, Nadia M, additional, Bernard, Léa, additional, Shah, Nirali N, additional, Walter, Roland, additional, Dipersio, John, additional, Perales, Miguel-Angel, additional, Loken, Michael R, additional, Breitschwerdt, Kyle, additional, Nath, Sritama, additional, Raffel, Glen, additional, and Cooper, Brenda W, additional

Published
2023
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31. List of Contributors

Author

Ahmad, Mufti Naeem, primary, Ahmed, Sairah, additional, Arslan, Shukaib, additional, Awan, Farrukh T., additional, Bashir, Qaiser, additional, Blaise, Didier, additional, Bodge, Megan, additional, Bramanti, Stefania, additional, Castagna, Luca, additional, Costa, Luciano J., additional, Cumpston, Aaron, additional, D’Souza, Anita, additional, de Lima, Marcos, additional, Devillier, Raynier, additional, Devlin, Rebecca, additional, Dignan, Fiona L., additional, Furst, Sabine, additional, Gopalakrishnan, Ragisha, additional, Gulbis, Alison, additional, Gupta, Vikas, additional, Haider, Ali, additional, Hari, Parameswaran, additional, Hosing, Chitra, additional, Hussain, Mohammed Junaid, additional, Innis-Shelton, Racquel, additional, Jagasia, Madan, additional, Kanate, Abraham S., additional, Kebriaei, Partow, additional, Khan, Maliha, additional, Khan, Shakila P., additional, Kharfan-Dabaja, Mohamed A., additional, Kim, Sola, additional, Kohorst, Mira A., additional, Krishnan, Amrita, additional, Mehta, Rohtesh S., additional, Mir, Muhammad Ayaz, additional, Narra, Ravi Kishore, additional, Nguyen, Nhu-Nhu, additional, Nieto, Yago, additional, Nikolaenko, Liana, additional, Olson, Amanda, additional, Pillinger, Kelly E., additional, Pinnix, Chelsea C., additional, Poon, L.M., additional, Ross, Kelly G., additional, Saif, Muhammad A., additional, Shah, Nirav N., additional, Shahid, Zainab, additional, Shaw, Bronwen E., additional, Shpall, Elizabeth J., additional, Siddiqi, Rabbia, additional, Tamari, Roni, additional, Tomlinson, Benjamin, additional, Usmani, Saad Zafar, additional, Veltri, Lauren, additional, Weisdorf, Daniel, additional, Yakoub-Agha, Ibrahim, additional, and Yan, Lily, additional

Published
2019
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33. Phase I study of intra-osseous co-transplantation of a single-unit cord blood and mesenchymal stromal cells with reduced intensity conditioning regimens

Author

Wang, Jiasheng, primary, Sanati, Farhad, additional, Firoozmand, Amin, additional, Fu, Pingfu, additional, Kolk, Merle, additional, Reese-Koc, Jane, additional, de Lima, Marcos, additional, Boughan, Kirsten, additional, Cooper, Brenda, additional, Caimi, Paolo, additional, Gallogly, Molly, additional, Otegbeye, Folashade, additional, Tomlinson, Benjamin, additional, and Metheny, Leland, additional

Published
2023
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34. Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings

Author

Garcia, Jacqueline S., primary, Flamand, Yael, additional, Penter, Livius, additional, Keng, Michael, additional, Tomlinson, Benjamin K., additional, Mendez, Lourdes M., additional, Koller, Paul, additional, Cullen, Nicole, additional, Arihara, Yohei, additional, Pfaff, Kathleen, additional, Wolff, Jacquelyn O., additional, Brunner, Andrew M., additional, Galinsky, Ilene, additional, Bashey, Asad, additional, Antin, Joseph H., additional, Cutler, Corey, additional, Ho, Vincent, additional, Jonas, Brian A., additional, Luskin, Marlise R., additional, Wadleigh, Martha, additional, Winer, Eric S., additional, Savell, Alexandra, additional, Leonard, Rebecca, additional, Robertson, Taylor, additional, Davids, Matthew S., additional, Streicher, Howard, additional, Rodig, Scott J., additional, Ritz, Jerome, additional, Wu, Catherine J., additional, DeAngelo, Daniel J., additional, Neuberg, Donna, additional, Stone, Richard M., additional, and Soiffer, Robert J., additional

Published
2023
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35. Supplementary Tables S1-S3 from Phase I Trial of Arginine Deprivation Therapy with ADI-PEG 20 Plus Docetaxel in Patients with Advanced Malignant Solid Tumors

Author

Tomlinson, Benjamin K., primary, Thomson, James A., primary, Bomalaski, John S., primary, Diaz, Monica, primary, Akande, Taiwo, primary, Mahaffey, Nichole, primary, Li, Tianhong, primary, Dutia, Mrinal P., primary, Kelly, Karen, primary, Gong, I-Yeh, primary, Semrad, Thomas, primary, Gandara, David R., primary, Pan, Chong-Xian, primary, and Lara, Primo N., primary

Published
2023
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37. A Multicenter Study of Post-Transplant Low-Dose Inotuzumab Ozogamicin to Prevent Relapse of Acute Lymphoblastic Leukemia

Author

Metheny, Leland, primary, Sobecks, Ronald, additional, Cho, Christina, additional, Fu, Pingfu, additional, Margevicius, Seunghee, additional, Wang, Jiasheng, additional, Ciarrone, Lisa, additional, Kopp, Shelby, additional, Convents, Robin D., additional, Majhail, Navneet, additional, Caimi, Paolo F., additional, Otegbeye, Folashade, additional, Cooper, Brenda W., additional, Gallogly, Molly, additional, Malek, Ehsan, additional, Tomlinson, Benjamin, additional, Gerds, Aaron T., additional, Hamilton, Betty, additional, Giralt, Sergio A., additional, Perales, Miguel-Angel, additional, and de Lima, Marcos, additional

Published
2023
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39. A Phase 1a/b Dose Escalation Study of the FLT3/BTK Inhibitor Luxeptinib (CG-806) in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Author

Goldberg, Aaron D, primary, Ohanian, Maro, additional, Koller, Paul B., additional, Cherry, Mohamad, additional, Altman, Jessica K., additional, Tomlinson, Benjamin, additional, Chandhok, Namrata Sonia, additional, Nguyen Haney, Donna, additional, Hu, Jia, additional, Sinha, Ranjeet Kumar, additional, Rice, William G, additional, and Bejar, Rafael, additional

Published
2022
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40. Circulating Tumor DNA Correlation with Lymphoma Response and Survival Outcomes at Multiple Time Points of Anti - CD19 CAR T Cell Therapy

Author

Caimi, Paolo F, primary, Di Trani, Martina, additional, Ghobadi, Armin, additional, Reese, Jane, additional, Tomlinson, Benjamin, additional, Otegbeye, Folashade, additional, Boughan, Kirsten M, additional, Gallogly, Molly, additional, Metheny, Leland, additional, Cooper, Brenda W., additional, Dropulic, Boro, additional, de Lima, Marcos J.G., additional, and Carlo-Stella, Carmelo, additional

Published
2022
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43. Long-Term Follow-Up Demonstrates Ongoing Efficacy Benefit of 131I-Apamistamab-led Allogeneic Hematopoietic Cell Transplantation in Older Patients With Active, R/R AML in the Phase 3 SIERRA Trial

Author

Seropian, Stuart, Gyurkocza, Boglarka, Nath, Rajneesh, Choe, Hannah, Litzow, Mark, Abboud, Camille, Koshy, Nebu, Stiff, Patrick, Tomlinson, Benjamin, Abhyankar, Sunil, Foran, James, Abedin, Sameem, Chen, George, Al-Kadhimi, Zaid, Kebriaei, Partow, Sabloff, Mitchell, Orozco, Johnnie, Jamieson, Katarzyna, Silverman, Margarida, Van Besien, Koen, Schuster, Michael, Law, Arjun, Mayer, Sebastian, Lazarus, Hillard, Spross, Jennifer, Li, Kate, Vusirikala, Madhuri, Sandmaier, Brenda, Pagel, John, Desai, Avinash, and Giralt, Sergio

Published
2024
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44. AML-545 Long-Term Follow-up Demonstrates Ongoing Efficacy Benefit of 131I-Apamistamab-led Allogeneic Hematopoietic Cell Transplantation in Older Patients With Active, R/R AML in the Phase 3 SIERRA Trial

Author

Seropian, Stuart, Gyurkocza, Boglarka, Nath, Rajneesh, Choe, Hannah, Litzow, Mark, Abboud, Camille, Koshy, Nebu, Stiff, Patrick, Tomlinson, Benjamin, Abhyankar, Sunil, Foran, James, Abedin, Sameem, Chen, George, Al-Kadhimi, Zaid, Kebriaei, Partow, Sabloff, Mitchell, Orozco, Johnnie, Jamieson, Katarzyna, Silverman, Margarida, Van Besien, Koen, Schuster, Michael, Law, Arjun, Mayer, Sebastian, Lazarus, Hillard, Spross, Jennifer, Li, Kate, Vusirikala, Madhuri, Sandmaier, Brenda, Pagel, John, Desai, Avinash, and Giralt, Sergio

Published
2024
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45. Phase I study of intra-osseous co-transplantation of a single-unit cord blood and mesenchymal stromal cells with reduced intensity conditioning regimens.

Author

Jiasheng Wang, Sanati, Farhad, Firoozmand, Amin, Pingfu Fu, Kolk, Merle, Reese-Koc, Jane, de Lima, Marcos, Boughan, Kirsten, Cooper, Brenda, Caimi, Paolo, Gallogly, Molly, Otegbeye, Folashade, Tomlinson, Benjamin, and Metheny, Leland

Subjects
CORD blood, STROMAL cells, HLA histocompatibility antigens, GRAFT versus host disease, BONE marrow
Abstract

Cord blood (CB) is a valuable graft source for patients undergoing allogeneic hematopoietic cell transplant (HCT) who lack human leukocyte antigen (HLA)- matched donors. However, single-unit CB-HCT is limited by the insufficient cell dose and slow engraftment. To overcome these limitations, we combined a single-unit CB with third-party healthy donors' bone marrow (BM) derived mesenchymal stromal cells (MSCs) to improve engraftment and injected intraosseously (IO) to enhance homing. In this phase I clinical trial, six patients with high-risk hematologic malignancies were enrolled and received allogeneic HCT using reduced intensity conditioning regimens. The primary objective was to determine the engraftment rate at day 42. The median age of enrolled patients was 68 years, and only one patient was in complete remission at the time of HCT. The median CB total nucleated cell dose was 3.2x107/kg. No serious adverse events were reported. Two patients had early deaths due to persistent disease and multi-drug resistant bacterial infection, respectively. Of the remaining four evaluable patients, all had successful neutrophil engraftment in a median of 17.5 days. No grade 3 or higher acute graft-versus-host disease (GvHD) was observed, and only one patient developed moderate-extensive chronic GvHD. In conclusion, IO co-transplantation of a single-unit CB and MSCs was feasible and resulted in a reasonable engraftment rate in these very high-risk patients. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Sex differences in adults with acute myeloid leukemia and the impact of sex on overall survival.

Author

Stabellini, Nickolas, Tomlinson, Benjamin, Cullen, Jennifer, Shanahan, John, Waite, Kristin, Montero, Alberto J., Barnholtz‐Sloan, Jill S., and Hamerschlak, Nelson

Subjects
*ACUTE myeloid leukemia, *OVERALL survival, *MEDICAL care
Abstract

Background: There is a male predominance of acute myeloid leukemia (AML) incidence, but survival data are conflicting. The objective of this study is to carry out a comprehensive analysis of sex differences in AML, and to investigate the impact of sex disparities in survival. Methods: The cohort included patients ≥18 years diagnosed with AML (2010–2022). Demographics, treatment patterns, treatment adverse events, and survival were analyzed. The population was described and compared by sex, and sex‐based risks and associations were obtained via Cox proportional‐hazards regression. Results: In total, 1020 AML patients were analyzed (57.4% males), with lower risk of death for females (aHR = 0.41, 95% CI 0.26–0.66). Among females, BMT (aHR = 0.51, 95% CI 0.27–0.97), hospitalization record (aHR = 0.65, 95%CI 0.45–0.93), and higher appointment completion rates (aHR = 0.98, 95% CI 0.98–0.98) were associated with lower risk of death. Overall, and similarly in males, higher age at diagnosis (aHR = 1.03, 95% CI 1.02–1.04) and a TP53 mutation (aHR = 2.24, 95% CI 1.69–2.97) were associated with higher risk of death. Conclusion: Sex differences exist in both AML incidence and overall survival. Treatment and health care factors should be addressed by caregivers and public policies developed to reduce mortality rates and mitigate existing sex differences. [ABSTRACT FROM AUTHOR]

Published
2023
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48. High Rates of Transplantation in the Phase III Sierra Trial Utilizing Anti-CD45 (Iodine) 131I-Apamistamab (Iomab-B) Conditioning with Successful Engraftment and Tolerability in Relapsed Refractory (R/R) Acute Myeloid Leukemia (AML) Patients after Lack of Response to Conventional Care and Targeted Therapies

Author

Gyurkocza, Boglarka, primary, Nath, Rajneesh, additional, Seropian, Stuart E., additional, Choe, Hannah, additional, Litzow, Mark R., additional, Koshy, Nebu, additional, Stiff, Patrick, additional, Abboud, Camille, additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil, additional, Hari, Parameswaran, additional, Chen, George L, additional, Al-Kadhimi, Zaid, additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Foran, James, additional, Kebriaei, Partow, additional, Jamieson, Katarzyna, additional, Magalhaes-Silverman, Margarida, additional, van Besien, Koen, additional, Schuster, Michael W, additional, Law, Arjun Datt, additional, Levy, Moshe Yair, additional, Lazarus, Hillard M., additional, Giralt, Sergio A, additional, Berger, Mark S., additional, Spross, Jennifer, additional, Desai, Avinash, additional, Reddy, Vijay, additional, and Pagel, John M., additional

Published
2022
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49. A Phase 1a/b Dose Escalation Study of the Mutation Agnostic FLT3/BTK Inhibitor Luxeptinib (CG-806) in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Author

Goldberg, Aaron D, primary, Ohanian, Maro, additional, Koller, Paul, additional, Altman, Jessica K., additional, Cherry, Mohamad, additional, Tomlinson, Benjamin, additional, Chandhok, Namrata, additional, Zhang, Hongying, additional, Rastgoo, Nasrin, additional, Benbatoul, Khalid, additional, Jin, Yuying, additional, Su, Genia, additional, Marango, Jotin, additional, Howell, Stephen B, additional, Rice, William G, additional, and Bejar, Rafael, additional

Published
2021
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50. Clinical Experience in the Randomized Phase 3 Sierra Trial: Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] Conditioning Enables Hematopoietic Cell Transplantation with Successful Engraftment and Acceptable Safety in Patients with Active, Relapsed/Refractory AML Not Responding to Targeted Therapies

Author

Gyurkocza, Boglarka, primary, Nath, Rajneesh, additional, Seropian, Stuart, additional, Choe, Hannah, additional, Litzow, Mark R., additional, Koshy, Nebu V., additional, Stiff, Patrick, additional, Abboud, Camille, additional, Tomlinson, Benjamin, additional, Abhyankar, Sunil, additional, Hari, Parameswaran, additional, Al-Kadhimi, Zaid S., additional, Chen, George L., additional, Sabloff, Mitchell, additional, Orozco, Johnnie J., additional, Foran, James M., additional, Kebriaei, Partow, additional, Jamieson, Katarzyna Joanna, additional, Magalhaes-Silverman, Margarida Magalhaes, additional, van Besien, Koen, additional, Schuster, Michael W., additional, Law, Arjun, additional, Levy, Moshe, additional, Lazarus, Hillard M, additional, Giralt, Sergio A, additional, Berger, Mark S., additional, Spross, Jennifer A, additional, Desai, Avinash G, additional, Reddy, Vijay, additional, and Pagel, John M., additional

Published
2021
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