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18 results on '"Tomlins, Paul J."'

1. Defining Ocular Surface Disease Activity and Damage Indices by an International Delphi Consultation

Author

Ahmad, Sajjad, Bron, Anthony, Burton, Matthew, Dart, John K., Figueiredo, Francisco, Geerling, Gerd, Hawksworth, Nicholas, Jacobs, Deborah, Kaye, Stephen, Kolli, S. Sai, Larkin, D. Frank, Mantry, Sanjay, Murray, Philip I., Liu, Christopher, Rauz, Saaeha, Shortt, Alex, Tomlins, Paul J., Verity, David, Watson, Stephanie L., Williams, Geraint P., Willoughby, Colin, Mathewson, Priscilla A., Hodson, James, and Bron, Anthony J.

Published
2017
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7. Defining Ocular Surface Disease Activity and Damage Indices by an International Delphi Consultation

Author

Mathewson, Priscilla A., primary, Williams, Geraint P., additional, Watson, Stephanie L., additional, Hodson, James, additional, Bron, Anthony J., additional, Rauz, Saaeha, additional, Ahmad, Sajjad, additional, Bron, Anthony, additional, Burton, Matthew, additional, Dart, John K., additional, Figueiredo, Francisco, additional, Geerling, Gerd, additional, Hawksworth, Nicholas, additional, Jacobs, Deborah, additional, Kaye, Stephen, additional, Kolli, S. Sai, additional, Larkin, D. Frank, additional, Mantry, Sanjay, additional, Murray, Philip I., additional, Liu, Christopher, additional, Shortt, Alex, additional, Tomlins, Paul J., additional, Verity, David, additional, and Willoughby, Colin, additional

Published
2017
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18. Elevation of conjunctival epithelial CD45INTCD11b⁺CD16⁺CD14⁻ neutrophils in ocular Stevens-Johnson syndrome and toxic epidermal necrolysis.

Author

Williams GP, Tomlins PJ, Denniston AK, Southworth HS, Sreekantham S, Curnow SJ, and Rauz S

Subjects
Acute Disease, Adolescent, Adult, Chronic Disease, Cross-Sectional Studies, Epithelium immunology, Female, Flow Cytometry, Humans, Male, Middle Aged, Young Adult, Antigens, CD immunology, Conjunctiva pathology, Conjunctival Diseases immunology, Neutrophils immunology, Stevens-Johnson Syndrome immunology
Abstract

Purpose: Ocular complications related to Stevens-Johnson Syndrome (SJS)-Toxic Epidermal Necrolysis (TEN) may persist and progress after resolution of systemic disease. This is thought to be related in part to persistent ocular innate-immune signaling. In this study, our aim was to characterize infiltrative conjunctival cellular profiles during acute (<12 months) and chronic (>12 months) disease., Methods: Consecutive patients presenting with SJS-TEN over a 12-month period were followed for 1 year. Detailed clinical examination and conjunctival impression cell recovery was analyzed by flow cytometry for the presence of intraepithelial leukocytes and compared with healthy controls (n = 21)., Results: Ten patients were recruited of whom six had acute disease and five were classified as TEN (SCORTEN = 1, n = 4). Conjunctival inflammation was graded as absent/mild in a total of nine patients; but despite this, evidence of fornix shrinkage was observed in nine subjects. This inversely correlated with disease duration (P < 0.05). A reduction in percentage of CD8αβ(+) T cells compared with controls (80% vs. 57%; P < 0.01) was associated with a corresponding increase in the number/percentage of CD45(INT)CD11b(+)CD16(+)CD14(-) neutrophils (186 vs. 3.4, P < 0.01, 31% vs. 0.8%, P < 0.001). Neutrophils inversely correlated with disease duration (r = -0.71, P = 0.03), yet there was no absolute change in the CD8αβ(+) or neutrophil populations during the study period (P = 1.0)., Conclusions: These data highlight that a neutrophilic infiltrate is present in mildly inflamed or clinically quiescent conjunctival mucosa in patients with ocular SJS-TEN, where neutrophil numbers inversely correlate with disease duration. Neutrophil persistence endorses the hypothesis of an unresolved innate-inflammatory process that might account for disease progression.

Published
2013
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