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Your search keyword '"Tomiyoshi, Katsumi"' showing total 111 results
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111 results on '"Tomiyoshi, Katsumi"'

2. Optimization Processes of Clinical Chelation-Based Radiopharmaceuticals for Pathway-Directed Targeted Radionuclide Therapy in Oncology.

Author

Tomiyoshi, Katsumi, Wilson, Lydia J., Mourtada, Firas, Mourtada, Jennifer Sims, Namiki, Yuta, Kamata, Wataru, Yang, David J., and Inoue, Tomio

Subjects
*DECAY schemes (Radioactivity), *TISSUE viability, *DISEASE management, *OVERALL survival, *RADIOBIOLOGY
Abstract

Targeted radionuclide therapy (TRT) for internal pathway-directed treatment is a game changer for precision medicine. TRT improves tumor control while minimizing damage to healthy tissue and extends the survival for patients with cancer. The application of theranostic-paired TRT along with cellular phenotype and genotype correlative analysis has the potential for malignant disease management. Chelation chemistry is essential for the development of theranostic-paired radiopharmaceuticals for TRT. Among image-guided TRT, 68Ga and 99mTc are the current standards for diagnostic radionuclides, while 177Lu and 225Ac have shown great promise for β- and α-TRT, respectively. Their long half-lives, potent radiobiology, favorable decay schemes, and ability to form stable chelation conjugates make them ideal for both manufacturing and clinical use. The current challenges include optimizing radionuclide production processes, coordinating chelation chemistry stability of theranostic-paired isotopes to reduce free daughters [this pertains to 225Ac daughters 221Fr and 213Bi]-induced tissue toxicity, and improving the modeling of micro dosimetry to refine dose–response evaluation. The empirical approach to TRT delivery is based on standard radionuclide administered activity levels, although clinical trials have revealed inconsistent outcomes and normal-tissue toxicities despite equivalent administered activities. This review presents the latest optimization methods for chelation-based theranostic radiopharmaceuticals, advancements in micro-dosimetry, and SPECT/CT technologies for quantifying whole-body uptake and monitoring therapeutic response as well as cytogenetic correlative analyses. [ABSTRACT FROM AUTHOR]

Published
2024
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17. 18F-fluorodeoxyglucose and11C-acetate positron emission tomography are useful modalities for diagnosing the histologic type of thymoma

Author

Shibata, Hidekatsu, primary, Nomori, Hiroaki, additional, Uno, Kimiichi, additional, Sakaguchi, Kazuya, additional, Nakashima, Rumi, additional, Iyama, Kenichi, additional, Tomiyoshi, Katsumi, additional, Kaji, Masahiro, additional, Goya, Tomoyuki, additional, Suzuki, Takashi, additional, and Horio, Hirotoshi, additional

Published
2009
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18. ENHANCEMENT OF SPLENIC GLUCOSE METABOLISM DURING ACUTE MALARIAL INFECTION: CORRELATION OF FINDINGS OF FDG-PET IMAGING WITH PATHOLOGICAL CHANGES IN A PRIMATE MODEL OF SEVERE HUMAN MALARIA

Author

KAWAI, SATORU, primary, HIGUCHI, TETSUYA, additional, MATSUMOTO, JUN, additional, YAMAGUCHI, HARUYASU, additional, INOUE, TOMIO, additional, SUGIYAMA, MUNEHIRO, additional, IKEDA, EIJI, additional, TOMIYOSHI, KATSUMI, additional, SUZUKI, MAMORU, additional, MATSUDA, HAJIME, additional, KHAN, NASIM, additional, ZHANG, HONG, additional, ENDO, KEIGO, additional, and KATAKURA, KEN, additional

Published
2006
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19. CEREBRAL METABOLIC REDUCTION IN SEVERE MALARIA: FLUORODEOXYGLUCOSE-POSITRON EMISSION TOMOGRAPHY IMAGING IN A PRIMATE MODEL OF SEVERE HUMAN MALARIA WITH CEREBRAL INVOLVEMENT

Author

SUGIYAMA, MUNEHIRO, primary, KATAKURA, KEN, additional, INOUE, TOMIO, additional, TOMIYOSHI, KATSUMI, additional, IKEDA, EIJI, additional, SUZUKI, MAMORU, additional, YAMAGUCHI, HARUYASU, additional, HIGUCHI, TETSUYA, additional, KAWAI, SATORU, additional, ENDO, KEIGO, additional, KHAN, NASIM, additional, and ZHANG, HONG, additional

Published
2004
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21. Tumor Diagnosis Using 18F-FDG SPECT

Author

スギヤマ, スミオ, スズキ, ヨシヒコ, マツザキ, ヒロシ, トミヨシ, カツミ, エンドウ, ケイゴ, Sugiyama, Sumio, Suzuki, Yoshihiko, Matsuzaki, Hiroshi, Tomiyoshi, Katsumi, Endo, Keigo, 杉山, 純夫, 鈴木, 良彦, 松崎, 宏, 冨吉, 勝美, 遠藤, 啓吾, スギヤマ, スミオ, スズキ, ヨシヒコ, マツザキ, ヒロシ, トミヨシ, カツミ, エンドウ, ケイゴ, Sugiyama, Sumio, Suzuki, Yoshihiko, Matsuzaki, Hiroshi, Tomiyoshi, Katsumi, Endo, Keigo, 杉山, 純夫, 鈴木, 良彦, 松崎, 宏, 冨吉, 勝美, and 遠藤, 啓吾

Published
1996

24. Nuclear Imaging of Bone Tumors: FDG-PET

Author

Aoki, Jun, primary, Inoue, Tomio, additional, Tomiyoshi, Katsumi, additional, Shinozaki, Tetsuya, additional, Watanabe, Hideomi, additional, Takagishi, Kenji, additional, and Endo, Keigo, additional

Published
2001
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28. Clinical Evaluation of Lung Scintigraphy with 99mTc-Technegas

Author

イノウエ, トミオ, ワタナベ, ナオユキ, オリウチ, ノボル, タテノ, マドカ, トミヨシ, カツミ, ミトモ, オサム, ハヤカワ, カズシゲ, ニイベ, ヒデオ, ササキ, ヤスヒト, Inoue, Tomio, Watanabe, Naoyuki, Oriuchi, Noboru, Tateno, Madoka, Tomiyoshi, Katsumi, Mitomo, Osamu, Hayakawa, Kazushige, Niibe, Hideo, Sasaki, Yasuhito, 井上, 登美夫, 渡辺, 直行, 織内, 昇, 舘野, 円, 冨吉, 勝美, 見供, 修, 早川, 和重, 新部, 英男, 佐々木, 康人, イノウエ, トミオ, ワタナベ, ナオユキ, オリウチ, ノボル, タテノ, マドカ, トミヨシ, カツミ, ミトモ, オサム, ハヤカワ, カズシゲ, ニイベ, ヒデオ, ササキ, ヤスヒト, Inoue, Tomio, Watanabe, Naoyuki, Oriuchi, Noboru, Tateno, Madoka, Tomiyoshi, Katsumi, Mitomo, Osamu, Hayakawa, Kazushige, Niibe, Hideo, Sasaki, Yasuhito, 井上, 登美夫, 渡辺, 直行, 織内, 昇, 舘野, 円, 冨吉, 勝美, 見供, 修, 早川, 和重, 新部, 英男, and 佐々木, 康人

Published
1990

32. Bilateral Breast Uptake of Tl-201 Chloride in a Nursing Woman

Author

WATANABE, NAOYUKI, primary, MATSUMOTO, MITSUOMI, additional, OHTAKE, HIDENORI, additional, HIRANO, TSUNEO, additional, AOYAGI, KEIKO, additional, YUKIHIRO, MASASHI, additional, FUKUSHIMA, YUMI, additional, HIGUCHI, TETSUYA, additional, TOMIYOSHI, KATSUMI, additional, INOUE, TOMIO, additional, and ENDO, KEIGO, additional

Published
1996
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34. A “Changing Stripe Sign” in Serial Pulmonary Perfusion Imaging

Author

WATANABE, NAOYUKI, primary, ORIUCHI, NOBORU, additional, SUZUKI, HIDEKI, additional, YUKIHIRO, MASASHI, additional, FUKUSHIMA, YUMI, additional, HIGUCHI, TETSUYA, additional, HIRANO, TSUNEO, additional, TOKUNAGA, MARI, additional, TOMIYOSHI, KATSUMI, additional, INOUE, TOMIO, additional, and ENDO, KEIGO, additional

Published
1996
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35. Study of ^<18>FDG image with Dual-head Gamma camera system

Author

Matsuzaki, Hiroshi, primary, Fujita, Katsuya, additional, Kanai, Susumu, additional, Akuzawa, Seiichi, additional, Uehara, Hiroshi, additional, Machimura, Fumihiko, additional, Wakamori, Hideo, additional, Kasahara, Hajime, additional, Suzuki, Kenichi, additional, and Tomiyoshi, Katsumi, additional

Published
1996
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38. Reversible Functional Asplenia

Author

HIRANO, TSUNEO, primary, TOMIYOSHI, KATSUMI, additional, TAKE, HIDENORI, additional, WATANABE, NAOYUKI, additional, ORIUCHI, NOBORU, additional, INOUE, TOMIO, additional, NARUSE, MASAKO, additional, and ENDO, KEIGO, additional

Published
1994
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41. 11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness.

Author

Shibata, Hidekatsu, Nomori, Hiroaki, Uno, Kimiichi, Iyama, Ken-ichi, Tomiyoshi, Katsumi, Nakashima, Rumi, Sakaguchi, Kazuya, Goya, Tomoyuki, Takanami, Iwao, Koizumi, Kiyoshi, Suzuki, Takashi, Kaji, Masahiro, and Horio, Hirotoshi

Abstract

To determine the usefulness of positron emission tomography (PET) with 11C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and 18F-fluorodeoxyglucose (FDG)-PET were compared. One hundred and sixty-nine adenocarcinomas with clinical stage IA and 53 benign nodules were examined by both AC- and FDG-PET before surgery. The sensitivity and specificity for discriminating benign/adenocarcinoma were compared between AC- and FDG-PET. The AC and FDG uptakes were examined to determine the relationship with tumor aggressiveness, i.e., pathological tumor stage, lymphatic, vascular, or pleural involvement, and proliferative activity determined by Ki-67 staining score. While the sensitivity of AC-PET was significantly higher than FDG-PET for bronchioloalveolar carcinoma (BAC) and well-differentiated (W/D) adenocarcinoma ( p < 0.001 and 0.006, respectively), there was no significant difference for moderately or poorly differentiated adenocarcinoma. The specificity was not different between them. While FDG uptakes were significantly higher in tumors with pathological advanced stages or those with lymphatic, vascular and/or pleural involvements than in tumors with pathological stage IA or those without these tumor involvements ( p = 0.04 to p < 0.001), AC uptake did not show significant differences between the respective sub-groups except according to the tumor stage. While both AC and FDG uptakes showed a significant correlation with Ki-67 staining scores ( p = 0.03 and p < 0.001, respectively), the correlation coefficient of former was lower than that of latter ( p = 0.07). While AC-PET can image BAC and W/D adenocarcinoma with a higher sensitivity than FDG-PET, it cannot evaluate tumor aggressiveness of clinical stage IA lung adenocarcinoma as well as FDG-PET. [ABSTRACT FROM AUTHOR]

Published
2009
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42. F-Fluorodeoxyglucose and C-Acetate Positron Emission Tomography Are Useful Modalities for Diagnosing the Histologic Type of Thymoma.

Author

Shibata, Hidekatsu, Nomori, Hiroaki, Uno, Kimiichi, Sakaguchi, Kazuya, Nakashima, Rumi, lyama, Kenichi, Tomiyoshi, Katsumi, Kaji, Masahiro, Goya, Tomoyuki, Suzuki, Takashi, and HirotoshivHorio

Subjects
CANCER research, TUMORS, TOMOGRAPHY, HISTOLOGY, POSITRON emission tomography
Abstract

The article presents the study which clarified the usefulness of emission tomography using F-flourodeoxyglucose (FDG) in predicting histologic type and tumor invasiveness of thymoma. The result indicates that FDG as well as the carbon 11-labeled acetate (AC) are useful in predicting the histologic types of thymoma despite the fact that they do not predict the invasiveness of thymomas assessed by tumor. FDG also differed significantly between stages I/II tumors and stage III/IV tumors.

Published
2009
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49. Evaluation of affinity of newly developed radiolabeled compound EISB on normal mice and amyloid deposition mice and its SPECT/CT imaging with 125I-EISB.

Author

Tokunaga, Yume, Suzuki, Ryoma, Kashiwa, Koki, and Tomiyoshi, Katsumi

Subjects
SINGLE-photon emission computed tomography, AMYLOID, MICE, IODINE isotopes, RADIOISOTOPES, BIOINDICATORS
Abstract

Highlights from the article: The second was normal mice and amyloids deposition mice SPECT/CT imaging with SP 125 sp I- EISB. After 30 min, the SPECT/CT imaging of normal mice and amyloid deposition mice is obtained using small animal SPECT/CT system FX3300 (TriFoil Imaging Inc., Chatsworth, CA).

Published
2019
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50. An INDO-MO Study of the Conformations and Electronic Structures of HCHOH+, CH3CHOH+, (CH3)2COH+, HCO2H2+, CH3CO2H2+, and CH3OH2+

Author

Ohkubo, Katsutoshi, Yoshida, Toshiaki, and Tomiyoshi, Katsumi

Abstract

INDO-SCF calculations were performed on several protonated compounds, HCHOH+CH3CHOH+, (CH3)2COH+, HCO2H2+, CH3CO2H2+, and CH3OH2+, and also on the corresponding parent molecules in order to investigate their conformations and electronic structures. Geometric optimization resulted in reasonable conformations as compared with the previous ab initiocalculations and in sufficient magnitudes of the energy differences between the rotational isomers in comparison with the NMR observations. The change in the electronic structures of the parent molecules due to protonation is also discussed by paying attention to the polarization caused by electron delocalization, hybridization at the proton-bound oxygen atom, the protonation energy, and the ionization potentials.

Published
1976
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