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202 results on '"Tomino, Takahiro"'

22. Outcome of living-donor liver transplantation for patients older than age 70 years, with respect to preserved performance status and graft quality

Author

Toshima, Takeo, primary, Harada, Noboru, additional, Itoh, Shinji, additional, Nakayama, Yuuki, additional, Toshida, Katsuya, additional, Tomiyama, Takahiro, additional, Kosai-Fujimoto, Yukiko, additional, Tomino, Takahiro, additional, Yoshiya, Shohei, additional, Nagao, Yoshihiro, additional, Kayashima, Hiroto, additional, and Yoshizumi, Tomoharu, additional

Published
2023
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25. Pretreatment eosinophil count predicts response to atezolizumab plus bevacizumab therapy in patients with hepatocellular carcinoma.

Author

Toshida, Katsuya, Itoh, Shinji, Yoshiya, Shohei, Nagao, Yoshihiro, Tomino, Takahiro, Izumi, Takuma, Iseda, Norifumi, Toshima, Takeo, Ninomiya, Mizuki, and Yoshizumi, Tomoharu

Subjects
HEPATOCELLULAR carcinoma, EOSINOPHILS, ATEZOLIZUMAB, BEVACIZUMAB, PROGRESSION-free survival
Abstract

Aim: Pretreatment peripheral blood markers have value in predicting the treatment outcome of various cancers. In particular, the eosinophil count has recently gained attention. However, no study has reported the influence of the pretreatment eosinophil count on the outcomes of atezolizumab plus bevacizumab (ATZ/BEV), which is the recommended first‐line systemic therapy for unresectable hepatocellular carcinoma (u‐HCC). Methods: We enrolled 114 patients with u‐HCC treated with ATZ/BEV (n = 48) or lenvatinib (n = 66). The patients receiving ATZ/BEV or lenvatinib were divided into two groups by calculating the cutoff value of the pretreatment eosinophil count. The groups were compared regarding the clinicopathological characteristics, outcomes, and incidence of adverse events (AEs). Results: Twenty‐three of 48 patients (47.9%) who received ATZ/BEV therapy were categorized as the ATZ/BEV‐eosinophil‐high group, which had better responses than the ATZ/BEV‐eosinophil‐low group (P = 0.0090). Kaplan–Meier curves revealed a trend toward significantly better progression‐free survival (PFS) in the ATZ/BEV‐eosinophil‐high group than the ATZ/BEV‐eosinophil‐low group (the median PFS: 4.7 months in the ATZ/BEV‐eosinophil‐low group vs 12.6 months in the ATZ/BEV‐eosinophil‐high group; P = 0.0064). Multivariate analysis showed that a low eosinophil count was an independent risk factor for worse PFS after ATZ/BEV therapy (P = 0.0424, hazard ratio: 2.24, 95% confidence interval: 1.02–4.89). AEs (≥ grade 3) were significantly more likely to occur in the ATZ/BEV‐eosinophil‐high group (P = 0.0285). The outcomes did not significantly differ between the LEN‐eosinophil‐high group and the LEN‐eosinophil‐low group. Conclusion: A high pretreatment eosinophil count predicted a better response to ATZ/BEV therapy for u‐HCC and was associated with the incidence of AEs (≥ grade 3). [ABSTRACT FROM AUTHOR]

Published
2024
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29. A new scoring system with simple preoperative parameters as predictors of early recurrence of pancreatic ductal adenocarcinoma

Author

Shimagaki, Tomonari, primary, Sugimachi, Keishi, additional, Mano, Yohei, additional, Tomino, Takahiro, additional, Onishi, Emi, additional, Nakashima, Yuichiro, additional, Sugiyama, Masahiko, additional, Yamamoto, Manabu, additional, Morita, Masaru, additional, Shimokawa, Mototsugu, additional, Yoshizumi, Tomoharu, additional, and Toh, Yasushi, additional

Published
2023
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30. A third dose of the BNT162b2 mRNA vaccine sufficiently improves the neutralizing activity against SARS-CoV-2 variants in liver transplant recipients

Author

Tomiyama, Takahiro, primary, Suzuki, Rigel, additional, Harada, Noboru, additional, Tamura, Tomokazu, additional, Toshida, Katsuya, additional, Kosai-Fujimoto, Yukiko-, additional, Tomino, Takahiro, additional, Yoshiya, Shohei, additional, Nagao, Yoshihiro, additional, Takeishi, Kazuki, additional, Itoh, Shinji, additional, Kobayashi, Nobuhiro, additional, Ito, Hayato, additional, Yoshio, Sachiyo, additional, Kanto, Tatsuya, additional, Yoshizumi, Tomoharu, additional, and Fukuhara, Takasuke, additional

Published
2023
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31. Clinical association between intraoperative indocyanine green fluorescence imaging pattern, preoperative Gd‐EOB‐DTPA‐enhanced magnetic resonance imaging findings, and histological differentiation in hepatocellular carcinoma

Author

Tomino, Takahiro, primary, Itoh, Shinji, additional, Fujita, Nobuhiro, additional, Okamoto, Daisuke, additional, Nakayama, Yuki, additional, Toshida, Katsuya, additional, Tomiyama, Takahiro, additional, Tsutsui, Yuriko, additional, Kosai, Yukiko, additional, Kurihara, Takeshi, additional, Nagao, Yoshihiro, additional, Morita, Kazutoyo, additional, Harada, Noboru, additional, Ushijima, Yasuhiro, additional, Kohashi, Kenichi, additional, Ishigami, Kousei, additional, Oda, Yoshinao, additional, and Yoshizumi, Tomoharu, additional

Published
2023
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34. The hemoglobin, albumin, lymphocyte, and platelet score is a prognostic factor for Child–Pugh A patients undergoing curative hepatic resection for single and small hepatocellular carcinoma

Author

Toshida, Katsuya, primary, Itoh, Shinji, additional, Kayashima, Hiroto, additional, Nagao, Yoshihiro, additional, Yoshiya, Shohei, additional, Tomino, Takahiro, additional, Fujimoto, Yukiko Kosai, additional, Tsutsui, Yuriko, additional, Nakayama, Yuki, additional, Harada, Noboru, additional, and Yoshizumi, Tomoharu, additional

Published
2023
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35. Prognostic significance for recurrence of fibroblast growth factor receptor 2 in intrahepatic cholangiocarcinoma patients undergoing curative hepatic resection

Author

Toshida, Katsuya, primary, Itoh, Shinji, additional, Yugawa, Kyohei, additional, Kosai, Yukiko, additional, Tomino, Takahiro, additional, Yoshiya, Shohei, additional, Nagao, Yoshihiro, additional, Kayashima, Hiroto, additional, Harada, Noboru, additional, Kohashi, Kenichi, additional, Oda, Yoshinao, additional, and Yoshizumi, Tomoharu, additional

Published
2023
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36. Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study

Author

Tomiyama, Takahiro, primary, Harada, Noboru, additional, Toshima, Takeo, additional, Nakayama, Yuki, additional, Toshida, Katsuya, additional, Morinaga, Akinari, additional, Kosai-Fujimoto, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Takeishi, Kazuki, additional, Nagao, Yoshihiro, additional, Morita, Kazutoyo, additional, Itoh, Shinji, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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37. Cancer‐associated fibroblasts promote tumor cell growth via miR ‐493‐5p in intrahepatic cholangiocarcinoma

Author

Toshida, Katsuya, primary, Itoh, Shinji, additional, Harada, Noboru, additional, Morinaga, Akinari, additional, Yugawa, Kyohei, additional, Tomiyama, Takahiro, additional, Kosai‐Fujimoto, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Nagao, Yoshihiro, additional, Morita, Kazutoyo, additional, Oda, Yoshinao, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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38. Autoimmune Hepatitis in an Immunosuppression-Free Patient Who Underwent Living Donor Liver Transplantation From an Identical Twin: A Case Report

Author

Toshida, Katsuya, primary, Toshima, Takeo, additional, Harada, Noboru, additional, Nakayama, Yuki, additional, Tomiyama, Takahiro, additional, Morinaga, Akinari, additional, Kosai-Fujimoto, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Nagao, Yoshihiro, additional, Morita, Kazutoyo, additional, Itoh, Shinji, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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39. A rare case of unresectable, microsatellite instability-high hepatocellular carcinoma and an examination of the tumor microenvironment

Author

Tomiyama, Takahiro, primary, Itoh, Shinji, additional, Toshida, Katsuya, additional, Morinaga, Akinari, additional, Fujimoto-Kosai, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Nagao, Yoshihiro, additional, Morita, Kazutoyo, additional, Harada, Noboru, additional, Kohashi, Kenichi, additional, Eguchi, Yuichiro, additional, Oda, Yoshinao, additional, Mori, Masaki, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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40. Low syntaxin 17 expression in donor liver is associated with poor graft prognosis in recipients of living donor liver transplantation

Author

Tomiyama, Takahiro, primary, Shimokawa, Masahiro, additional, Harada, Noboru, additional, Toshida, Katsuya, additional, Morinaga, Akinari, additional, Kosai‐Fujimoto, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Nagao, Yoshihiro, additional, Toshima, Takeo, additional, Morita, Kazutoyo, additional, Itoh, Shinji, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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43. Outcomes of living‐donor liver transplantation for acute‐on‐chronic liver failure based on newly proposed criteria in Japan

Author

Toshima, Takeo, primary, Harada, Noboru, additional, Itoh, Shinji, additional, Morita, Kazutoyo, additional, Nagao, Yoshihiro, additional, Kurihara, Takeshi, additional, Tomino, Takahiro, additional, Kosai‐Fujimoto, Yukiko, additional, Morinaga, Akinari, additional, Tomiyama, Takahiro, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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44. Comparison of the prognostic effect of sarcopenia on atezolizumab plus bevacizumab and lenvatinib therapy in hepatocellular carcinoma patients

Author

Toshida, Katsuya, primary, Itoh, Shinji, additional, Tomiyama, Takahiro, additional, Morinaga, Akinari, additional, Kosai, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Nagao, Yoshihiro, additional, Morita, Kazutoyo, additional, Harada, Noboru, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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45. Cancer‐associated fibroblasts promote tumor cell growth via miR‐493‐5p in intrahepatic cholangiocarcinoma.

Author

Toshida, Katsuya, Itoh, Shinji, Harada, Noboru, Morinaga, Akinari, Yugawa, Kyohei, Tomiyama, Takahiro, Kosai‐Fujimoto, Yukiko, Tomino, Takahiro, Kurihara, Takeshi, Nagao, Yoshihiro, Morita, Kazutoyo, Oda, Yoshinao, and Yoshizumi, Tomoharu

Abstract

The association between tumor microenvironment (TME) and cancer‐associated fibroblasts (CAFs) in intrahepatic cholangiocarcinoma (ICC) progression is poorly understood. This study aimed to reveal whether specific microRNAs (miRNAs) in extracellular vesicles (EVs) derived from CAFs were involved in ICC progression. Conditioned medium (CM) and EVs in the CM of CAFs and normal fibroblasts (NFs) derived from ICC specimens were used to investigate the effects on tumor cell lines. miRNA microarray assay was used to examine the miRNAs of EVs derived from CAFs and NFs in ICC, and the effects of miR‐493‐5p on tumor cell lines were examined. Additionally, databases were used to identify miR‐493‐5p targets, and the relationship between prognosis of ICC patients and cocaine‐ and amphetamine‐regulated transcript propeptide (CARTPT), one of the targets of miR‐493‐5p, expression in ICC tissues was retrospectively analyzed. Compared with NF‐derived CM and EVs, CAF‐derived CM and EVs promoted cell lines in proliferation, scratch, migration, and invasion assays. miRNA microarray analysis revealed that miR‐493‐5p was significantly increased in CAF‐derived EVs compared to NF‐derived EVs. Tumor cell lines transfected with miR‐493‐5p were promoted in proliferation and scratch assays. Immunohistochemical staining was performed on 76 ICC specimens; both overall and recurrence‐free survival rates were significantly worse in the CARTPT‐negative group. Univariate and multivariate analyses showed that low CARTPT expression was an independent poor prognostic factor for overall and recurrence‐free survival. Overall, our data suggest that CAFs in the ICC TME suppress CARTPT in tumor cells and promote tumor cells via miR‐493‐5p in EVs. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Myeloid‑derived suppressor cell infiltration is associated with a poor prognosis in patients with hepatocellular carcinoma

Author

Tomiyama, Takahiro, primary, Itoh, Shinji, additional, Iseda, Norifumi, additional, Toshida, Katuya, additional, Morinaga, Akinari, additional, Yugawa, Kyohei, additional, Fujimoto, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Nagao, Yoshihiro, additional, Morita, Kazutoyo, additional, Harada, Noboru, additional, Kohashi, Kenichi, additional, Oda, Yoshinao, additional, Mori, Masaki, additional, and Yoshizumi, Tomoharu, additional

Published
2022
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48. ASO Author Reflections: Future Perspectives of Novel Prognostic Predictor of Vessels that Encapsulate Tumor Cluster (VETC) for Hepatocellular Carcinoma

Author

Toshima, Takeo, primary, Yoshizumi, Tomoharu, additional, Itoh, Shinji, additional, Toshida, Katsuya, additional, Tomiyama, Takahiro, additional, Morinaga, Akinari, additional, Kosai-Fujimoto, Yukiko, additional, Tomino, Takahiro, additional, Kurihara, Takeshi, additional, Morita, Kazutoyo, additional, and Harada, Noboru, additional

Published
2021
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50. Prevention of bile duct injury using indocyanine green fluorescence in laparoscopic liver cyst fenestration for giant liver cyst: a case report.

Author

Shimagaki, Tomonari, Itoh, Shinji, Toshida, Katsuya, Tomiyama, Takahiro, Morinaga, Akinari, Kosai, Yukiko, Tomino, Takahiro, Kurihara, Takeshi, Nagao, Yoshihiro, Morita, Kazutoyo, Harada, Noboru, and Yoshizumi, Tomoharu

Subjects
BILE ducts, INDOCYANINE green, CYSTS (Pathology), CYST rupture, FLUORESCENCE, AORTIC rupture, CHOLANGITIS
Abstract

The case is a 78-year-old female. A giant liver cyst was pointed out by abdominal echo from 7 years ago, but because the size of the cyst tended to increase, it was decided to operate taking into account the risk of the cyst rupturing. Laparoscopic surgery was started, and the cyst contents did not fluorescent when observed by the indocyanine green (ICG) fluorescence method. Laparoscopic liver cyst fenestration was performed using the ICG fluorescence method, paying attention to the damage to the bile duct excluded by the cyst. The opened cyst was filled with the greater omentum. In this report, we describe that the ICG fluorescence method can evaluate the presence or absence of bile leakage from the hepatic dissection and the running of the bile duct on the inner wall of the cyst, and is considered to contribute to safer laparoscopic liver cyst fenestration. [ABSTRACT FROM AUTHOR]

Published
2022
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