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1. Effects of astaxanthin supplementation in healthy and obese dogs

Author

Murai T, Kawasumi K, Tominaga K, Okada Y, Kobayashi M, and Arai T

Subjects
Astaxanthin supplementation, obese dogs, anti-oxidative activity, liver function, Veterinary medicine, SF600-1100
Abstract

Tae Murai,1 Koh Kawasumi,1 Kumi Tominaga,2 Yuki Okada,1 Motoo Kobayashi,1 Toshiro Arai1 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan; 2Research and Development Division, AstaReal Co. Ltd., Minato-ku, Tokyo 105-0011, Japan Background: Since astaxanthin (ASX) has potent anti-oxidative effects with inhibitory action of lipid peroxidation and singlet oxygen quenching activity, it is widely used as a functional food for keeping good health in human. Obesity is a risk factor for various metabolic disorders. It is characterized by low-grade chronic inflammation based on oxidative stress by excessively produced ROS. From the point of preventive medicine, natural compounds have been proposed as potential therapeutic agents in the prevention of metabolic disorder in companion animals. The purpose of this study is to evaluate the effects of ASX supplementation in healthy and obese dogs. Materials and methods: Ten healthy beagle dogs and 5 clinically obese dogs were used in this study. The healthy beagle dogs were randomly divided into 2 groups as follows: control and test groups. The test group dogs received ASX supplementation mixed with the food for 6 weeks. Five clinically obese dogs received ASX supplementation for 8 weeks. Metabolites, hormones and enzymes were measured before and after ASX supplementation. Results: In the healthy dog groups, after 6 weeks, plasma triglyceride (TG) and malondialdehyde concentrations and lactate dehydrogenase (LDH) values significantly decreased in the test group. There was no significant difference in the control group. In clinically obese dogs, plasma TG concentration decreased after 8 weeks of ASX supplementation. Plasma alanine aminotransferase and LDH values clearly decreased in all 5 dogs and 4 dogs out of 5 dogs, respectively. Conclusion: ASX supplementation (0.3 mg/kg body weight/day) for 6 weeks in healthy dogs and 8 weeks in obese dogs induced the elevation of antioxidant function and of liver function by ameliorating lipid metabolism. Keywords: astaxanthin, obese dogs, lipid metabolism, anti-oxidative activity, liver function

Published
2019

2. Symptom predictors of response to electroconvulsive therapy in older patients with treatment-resistant depression

Author

Tominaga K, Okazaki M, Higuchi H, Utagawa I, Nakamura E, and Yamaguchi N

Subjects
Medicine (General), R5-920
Abstract

Keiichiro Tominaga¹, Mioto Okazaki¹, Hisashi Higuchi¹, Itaru Utagawa¹, Etsuko Nakamura², Noboru Yamaguchi¹¹Department of Neuropsychiatry, St Marianna University School of Medicine, Miyamae-ku, Kawasaki City, Kanagawa, ²Tsurukawa Sanatorium Hospital, Machida City, Tokyo, JapanBackground: Electroconvulsive therapy (ECT) has been used for treatment-resistant depression. However, predictors of response to ECT have not been adequately studied using the Montgomery and Åsberg Depression Rating Scale, especially in older patients with treatment-resistant depression.Methods: This study included 18 Japanese patients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision criteria for a diagnosis of major depressive disorder or bipolar disorder with a current major depressive episode, and met the definition of treatment-resistant depression outlined by Thase and Rush, scoring ≥21 on the Montgomery and Åsberg Depression Rating Scale. The three-factor model of the Montgomery and Åsberg Depression Rating Scale was used for analysis. Factor 1 was defined by three items, factor 2 by four items, and factor 3 by three items, representing dysphoria, retardation, and vegetative symptoms, respectively. ECT was performed twice a week for a total of six sessions using a Thymatron System IV device with the brief pulse technique. Clinical responses were defined on the basis of a ≥50% decrease in total pretreatment Montgomery and Åsberg Depression Rating Scale scores.Results: The mean pretreatment factor 2 score for responders (n = 7) was significantly lower than that for nonresponders (n = 11). Furthermore, a significant difference in mean factor 3 score between responders and nonresponders was observed one week after six sessions of ECT, indicating a time lag of response. No significant differences were observed for age, number of previous episodes, and duration of the current episode between responders and nonresponders.Conclusion: This study suggests that a low pretreatment factor 2 score is a good predictor of response to ECT in older patients with major depression.Keywords: factor analysis, electroconvulsive therapy, refractory depression, Montgomery and Åsberg Depression Rating Scale, predictors of response

Published
2011

13. Global data set of long-term summertime vertical temperature profiles in 153 lakes

Author

Pilla, R, Mette, E, Williamson, C, Adamovich, B, Adrian, R, Anneville, O, Balseiro, E, Ban, S, Chandra, S, Colom-Montero, W, Devlin, S, Dix, M, Dokulil, M, Feldsine, N, Feuchtmayr, H, Fogarty, N, Gaiser, E, Girdner, S, Gonzalez, M, Hambright, K, Hamilton, D, Havens, K, Hessen, D, Hetzenauer, H, Higgins, S, Huttula, T, Huuskonen, H, Isles, P, Joehnk, K, Keller, W, Klug, J, Knoll, L, Korhonen, J, Korovchinsky, N, Koster, O, Kraemer, B, Leavitt, P, Leoni, B, Lepori, F, Lepskaya, E, Lottig, N, Luger, M, Maberly, S, Macintyre, S, Mcbride, C, Mcintyre, P, Melles, S, Modenutti, B, Muller-Navarra, D, Pacholski, L, Paterson, A, Pierson, D, Pislegina, H, Plisnier, P, Richardson, D, Rimmer, A, Rogora, M, Rogozin, D, Rusak, J, Rusanovskaya, O, Sadro, S, Salmaso, N, Saros, J, Sarvala, J, Saulnier-Talbot, E, Schindler, D, Shimaraeva, S, Silow, E, Sitoki, L, Sommaruga, R, Straile, D, Strock, K, Swain, H, Tallant, J, Thiery, W, Timofeyev, M, Tolomeev, A, Tominaga, K, Vanni, M, Verburg, P, Vinebrooke, R, Wanzenbock, J, Weathers, K, Weyhenmeyer, G, Zadereev, E, Zhukova, T, Pilla R. M., Mette E. M., Williamson C. E., Adamovich B. V., Adrian R., Anneville O., Balseiro E., Ban S., Chandra S., Colom-Montero W., Devlin S. P., Dix M. A., Dokulil M. T., Feldsine N. A., Feuchtmayr H., Fogarty N. K., Gaiser E. E., Girdner S. F., Gonzalez M. J., Hambright K. D., Hamilton D. P., Havens K., Hessen D. O., Hetzenauer H., Higgins S. N., Huttula T. H., Huuskonen H., Isles P. D. F., Joehnk K. D., Keller W. B., Klug J., Knoll L. B., Korhonen J., Korovchinsky N. M., Koster O., Kraemer B. M., Leavitt P. R., Leoni B., Lepori F., Lepskaya E. V., Lottig N. R., Luger M. S., Maberly S. C., MacIntyre S., McBride C., McIntyre P., Melles S. J., Modenutti B., Muller-Navarra D. C., Pacholski L., Paterson A. M., Pierson D. C., Pislegina H. V., Plisnier P. -D., Richardson D. C., Rimmer A., Rogora M., Rogozin D. Y., Rusak J. A., Rusanovskaya O. O., Sadro S., Salmaso N., Saros J. E., Sarvala J., Saulnier-Talbot E., Schindler D. E., Shimaraeva S. V., Silow E. A., Sitoki L. M., Sommaruga R., Straile D., Strock K. E., Swain H., Tallant J. M., Thiery W., Timofeyev M. A., Tolomeev A. P., Tominaga K., Vanni M. J., Verburg P., Vinebrooke R. D., Wanzenbock J., Weathers K., Weyhenmeyer G. A., Zadereev E. S., Zhukova T. V., Pilla, R, Mette, E, Williamson, C, Adamovich, B, Adrian, R, Anneville, O, Balseiro, E, Ban, S, Chandra, S, Colom-Montero, W, Devlin, S, Dix, M, Dokulil, M, Feldsine, N, Feuchtmayr, H, Fogarty, N, Gaiser, E, Girdner, S, Gonzalez, M, Hambright, K, Hamilton, D, Havens, K, Hessen, D, Hetzenauer, H, Higgins, S, Huttula, T, Huuskonen, H, Isles, P, Joehnk, K, Keller, W, Klug, J, Knoll, L, Korhonen, J, Korovchinsky, N, Koster, O, Kraemer, B, Leavitt, P, Leoni, B, Lepori, F, Lepskaya, E, Lottig, N, Luger, M, Maberly, S, Macintyre, S, Mcbride, C, Mcintyre, P, Melles, S, Modenutti, B, Muller-Navarra, D, Pacholski, L, Paterson, A, Pierson, D, Pislegina, H, Plisnier, P, Richardson, D, Rimmer, A, Rogora, M, Rogozin, D, Rusak, J, Rusanovskaya, O, Sadro, S, Salmaso, N, Saros, J, Sarvala, J, Saulnier-Talbot, E, Schindler, D, Shimaraeva, S, Silow, E, Sitoki, L, Sommaruga, R, Straile, D, Strock, K, Swain, H, Tallant, J, Thiery, W, Timofeyev, M, Tolomeev, A, Tominaga, K, Vanni, M, Verburg, P, Vinebrooke, R, Wanzenbock, J, Weathers, K, Weyhenmeyer, G, Zadereev, E, Zhukova, T, Pilla R. M., Mette E. M., Williamson C. E., Adamovich B. V., Adrian R., Anneville O., Balseiro E., Ban S., Chandra S., Colom-Montero W., Devlin S. P., Dix M. A., Dokulil M. T., Feldsine N. A., Feuchtmayr H., Fogarty N. K., Gaiser E. E., Girdner S. F., Gonzalez M. J., Hambright K. D., Hamilton D. P., Havens K., Hessen D. O., Hetzenauer H., Higgins S. N., Huttula T. H., Huuskonen H., Isles P. D. F., Joehnk K. D., Keller W. B., Klug J., Knoll L. B., Korhonen J., Korovchinsky N. M., Koster O., Kraemer B. M., Leavitt P. R., Leoni B., Lepori F., Lepskaya E. V., Lottig N. R., Luger M. S., Maberly S. C., MacIntyre S., McBride C., McIntyre P., Melles S. J., Modenutti B., Muller-Navarra D. C., Pacholski L., Paterson A. M., Pierson D. C., Pislegina H. V., Plisnier P. -D., Richardson D. C., Rimmer A., Rogora M., Rogozin D. Y., Rusak J. A., Rusanovskaya O. O., Sadro S., Salmaso N., Saros J. E., Sarvala J., Saulnier-Talbot E., Schindler D. E., Shimaraeva S. V., Silow E. A., Sitoki L. M., Sommaruga R., Straile D., Strock K. E., Swain H., Tallant J. M., Thiery W., Timofeyev M. A., Tolomeev A. P., Tominaga K., Vanni M. J., Verburg P., Vinebrooke R. D., Wanzenbock J., Weathers K., Weyhenmeyer G. A., Zadereev E. S., and Zhukova T. V.

Abstract

Climate change and other anthropogenic stressors have led to long-term changes in the thermal structure, including surface temperatures, deepwater temperatures, and vertical thermal gradients, in many lakes around the world. Though many studies highlight warming of surface water temperatures in lakes worldwide, less is known about long-term trends in full vertical thermal structure and deepwater temperatures, which have been changing less consistently in both direction and magnitude. Here, we present a globally-expansive data set of summertime in-situ vertical temperature profiles from 153 lakes, with one time series beginning as early as 1894. We also compiled lake geographic, morphometric, and water quality variables that can influence vertical thermal structure through a variety of potential mechanisms in these lakes. These long-term time series of vertical temperature profiles and corresponding lake characteristics serve as valuable data to help understand changes and drivers of lake thermal structure in a time of rapid global and ecological change.

Published
2021

22. sj-pdf-1-jdr-10.1177_00220345221075966 ��� Supplemental material for Tongue Muscle for the Analysis of Head Muscle Regeneration Dynamics

Author

Goto, A., Kokabu, S., Dusadeemeelap, C., Kawaue, H., Matsubara, T., Tominaga, K., and Addison, W.N.

Subjects
110599 Dentistry not elsewhere classified, FOS: Materials engineering, FOS: Clinical medicine, 91299 Materials Engineering not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-jdr-10.1177_00220345221075966 for Tongue Muscle for the Analysis of Head Muscle Regeneration Dynamics by A. Goto, S. Kokabu, C. Dusadeemeelap, H. Kawaue, T. Matsubara, K. Tominaga and W.N. Addison in Journal of Dental Research

Published
2022
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32. Ultrafast Dynamics in Intermolecular Electron Transfer

Author

Yoshihara, K., Pal, H., Shirota, H., Nagasawa, Y., Tominaga, K., Goldanskii, Vitalii I., editor, Schäfer, Fritz Peter, editor, Toennies, J. Peter, editor, Lotsch, Helmut K. V., editor, Barbara, Paul F., editor, Fujimoto, James G., editor, Knox, Wayne H., editor, and Zinth, Wolfgang, editor

Published
1996
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37. A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma

Author

Sugawa, T., Fujiwara, Y., Yamagami, H., Watanabe, K., Tanigawa, T., Shiba, M., Watanabe, T., Tominaga, K., Oshitani, N., Higuchi, K., and Arakawa, T.

Subjects
Gastroesophageal reflux -- Development and progression, Gastroesophageal reflux -- Research, Asthma -- Development and progression, Asthma -- Research, Animal models in research -- Evaluation, Health
Published
2008

38. Non-steroidal anti-inflammatory drug-induced small intestinal damage is toll-like receptor 4 dependent

Author

Watanabe, T., Higuchi, K., Kobata, A., Nishio, H., Tanigawa, T., Shiba, M., Tominaga, K., Fujiwara, Y., Oshitani, N., Asahara, T., Nomoto, K., Takeuchi, K., and Arakawa, T.

Subjects
Cytokines -- Physiological aspects, Indomethacin -- Complications and side effects, Gram-negative bacteria -- Physiological aspects, Drugs -- Health aspects, Drugs -- Development and progression, Health
Published
2008

47. Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis

Author

Fujii, S., Tominaga, K., Kitajima, K., Takeda, J., Kusaka,T., Fujita, M., Ichikawa, K., Tomita, S., Ohkura, Y., Ono, Y., Imura, J., Chiba, T., and Fujimori, T.

Subjects
Colorectal cancer -- Risk factors, Ulcerative colitis -- Complications and side effects, Genetic markers -- Analysis, Estrogen -- Receptors, Estrogen -- Analysis, Health
Published
2005

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