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12 results on '"Tomaszewski, Elyse"'

4. Vaccination with bispecific antibody armed T cells (BATC) in metastatic breast cancer patients and transfer of anti-breast cancer immunity in primed T cells after stem cell transplant: a proof of principle study

Author

Thakur, Archana, primary, Lum, Lawrence G, additional, Kondadasule, Vidya, additional, Rathore, Ritesh, additional, Al-Kadhimi, Zaid, additional, Tomaszewski, Elyse, additional, Schalk, Dana, additional, Uberti, Joseph, additional, and Ratanatharathorn, Voravit, additional

Published
2015
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5. Transfer of anti-breast cancer immunity induced by infusions of bispecific antibody armed T cells and boosted with ex vivo primed T cells after stem cell transplant in metastatic breast cancer patients.

Author

Thakur, Archana, primary, Lum, Lawrence G., additional, Rathore, Ritesh, additional, Al-Kadhimi, Zaid, additional, Tomaszewski, Elyse, additional, Schalk, Dana, additional, Liu, Qin, additional, Uberti, Joseph P., additional, and Ratanatharathorn, Voravit, additional

Published
2015
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6. Five advanced pancreatic cancer patients in a Phase I study of anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (BATS)

Author

Lum, Lawrence G, primary, Choi, Minsig, additional, Thakur, Archana, additional, Deol, Abhinav, additional, Fields, Kristie, additional, Tomaszewski, Elyse, additional, Schalk, Dana, additional, Kondadasule, Vidya, additional, Dyson, Greg, additional, Mahaseth, Hemchandra, additional, Philip, Philip, additional, and Shields, Anthony, additional

Published
2015
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7. Maspin expression in prostate tumor elicits host anti-tumor immunity

Author

Dzinic, Sijana H., primary, Chen, Kang, additional, Thakur, Archana, additional, Kaplun, Alexander, additional, Daniel Bonfil, R., additional, Li, Xiaohua, additional, Liu, Jason, additional, Margarida Bernardo, M., additional, Saliganan, Allen, additional, Back, Jessica B., additional, Yano, Hiroshi, additional, Schalk, Dana L., additional, Tomaszewski, Elyse N., additional, Beydoun, Ahmed S., additional, Dyson, Gregory, additional, Mujagic, Adelina, additional, Krass, David, additional, Dean, Ivory, additional, Mi, Qing-Sheng, additional, Heath, Elisabeth, additional, Sakr, Wael, additional, Lum, Lawrence G., additional, and Sheng, Shijie, additional

Published
2014
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9. Induction Of Anti-Myeloma Cellular and Humoral Immunity By Pre-Targeting Clonogenic Myeloma Cells Prior To Stem Cell Transplant With T Cells Armed With Anti-CD3 x Anti-CD20 Bispecific Antibody Leads To Transfer Of Cellular and Humoral Anti-Myeloma Immunity

Author

Lum, Lawrence G, primary, Thakur, Archana, additional, Al-Kadhimi, Zaid, additional, Deol, Abhinav, additional, Ayash, Lois, additional, Tomaszewski, Elyse N., additional, Yano, Hiroshi, additional, Schalk, Dana L, additional, Kondadasula, Sri Vidya, additional, Steele, Patricia A., additional, Zonder, Jeffrey A., additional, Uberti, Joseph P., additional, Ratanatharathorn, Voravit, additional, and Abidi, Muneer H., additional

Published
2013
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11. Transfer of Cellular and Humoral Anti-Tumor Immunity with Immune T Cells After Stem Cell Transplant (SCT) for Metastatic Breast Cancer Following “Vaccination” with Anti-CD3 x Anti-Her2/Neu Bispecific Antibody (Her2Bi) Armed Activated T Cells

Author

Thakur, Archana, primary, Al-Kadhimi, Zaid, additional, Pray, Cassara, additional, Tomaszewski, Elyse N., additional, Rathore, Ritesh, additional, Steele, Patricia A., additional, Abidi, Muneer H., additional, Ayash, Lois, additional, Schalk, Dana L, additional, Myers, Karen, additional, Mitchell, Alice, additional, Deol, Abhinav, additional, Uberti, Joseph P., additional, Ratanatharathorn, Voravit, additional, and Lum, Lawrence G, additional

Published
2011
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12. Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway.

Author

Thakur, Archana, Schalk, Dana, Tomaszewski, Elyse, Kondadasula, Sri Vidya, Yano, Hiroshi, Sarkar, Fazlul H., and Lum, Lawrence G.

Subjects
EPIDERMAL growth factor receptors, PANCREATIC tumors, SUPPRESSOR cells, PROSTAGLANDINS E, PANCREATIC cancer, BISPECIFIC antibodies, CYTOKINES
Abstract

Background: Myeloid-derived suppressor cells (MDSCs) are one of the major components of the immune-suppressive network, play key roles in tumor progression and limit therapeutic responses. Recently, we reported that tumor spheres formed by breast cancer cell lines were visibly smaller in a Th1 enriched microenvironment with significantly reduced differentiation of MDSC populations in 3D culture. In this study, we investigated the mechanism(s) of bispecific antibody armed ATC mediated inhibition of MDSC in the presence or absence of Th1 microenvironment. Methods: We used 3D co-culture model of peripheral blood mononuclear cells (PBMC) with pancreatic cancer cells MiaPaCa-2 [MiaE] and gemcitabine resistant MiaPaCa-GR [MiaM] cells to generate MDSC in the presence or absence of Th1 cytokines and EGFRBi armed ATC (aATC). Results: We show significantly decreased differentiation of MDSC (MiaE, p<0.005; MiaM, p<0.05) in the presence of aATC with or without Th1 cytokines. MDSC recovered from control cultures (without aATC) showed potent ability to suppress T cell functions compared to those recovered from aATC containing co-cultures. Reduced accumulation of MDSC was accompanied by significantly lower levels of COX2 (p<0.0048), PGE2 (p<0.03), and their downstream effector molecule Arginase-1 (p<0.01), and significantly higher levels of TNF-a, IL-12 and chemokines CCL3, CCL4, CCL5, CXCL9 and CXCL10 under aATC induced Th1 cytokine enriched microenvironment Conclusions: These data suggest aATC can suppress MDSC differentiation and attenuation of their suppressive activity through down regulation of COX2, PGE2 and ARG1 pathway that is potentiated in presence of Th1 cytokines, suggesting that Th1 enriching immunotherapy may be beneficial in pancreatic cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2012
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