1. The epidemiology of gram-negative bacteremia in Lebanon: a study in four hospitals.
- Author
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Nasr J, Abdessamad H, Mina J, Haykal T, Jamil Y, Abboud E, Mahdi A, Asmar R, Abi Assaad R, Alameddine D, Bourji A, Mahdi M, Abdulaal R, Tomassian S, El Ahmadieh H, Azzam W, Mokhbat JE, Moghnieh R, Rodriguez-Morales AJ, and Husni R
- Subjects
- Humans, Lebanon epidemiology, Retrospective Studies, Male, Female, Middle Aged, Aged, Hospitals statistics & numerical data, Adult, Cross Infection epidemiology, Cross Infection microbiology, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa isolation & purification, Microbial Sensitivity Tests, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae isolation & purification, Drug Resistance, Bacterial, Aged, 80 and over, Risk Factors, Acinetobacter baumannii drug effects, Acinetobacter baumannii isolation & purification, Bacteremia epidemiology, Bacteremia microbiology, Bacteremia drug therapy, Gram-Negative Bacterial Infections epidemiology, Gram-Negative Bacterial Infections microbiology, Gram-Negative Bacterial Infections drug therapy, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents pharmacology, Gram-Negative Bacteria drug effects, Gram-Negative Bacteria isolation & purification
- Abstract
Introduction: Gram-negative bacteremia is a life-threatening infection with high morbidity and mortality. Its incidence is rising worldwide, and treatment has become more challenging due to emerging bacterial resistance. Little data is available on the burden and outcome of such infections in Lebanon., Methods: We conducted this retrospective study in four Lebanese hospitals. Data on medical conditions and demographics of 2400 patients diagnosed with a bloodstream infection based on a positive blood culture were collected between January 2014 and December 2020., Results: Most bacteremias were caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, with the more resistant organisms being hospital-acquired. Third-generation cephalosporin and quinolone resistance was steady throughout the study, but carbapenem resistance increased. Mortality with such infections is high, but carbapenem resistance or infection with Pseudomonas or Acinetobacter species were significant risk factors for poor outcomes., Conclusion: This is the first multi-center study from Lebanon on gram-negative bacteremia, resistance patterns, and factors associated with a poor outcome. More surveillance is needed to provide data to guide empirical treatment for bacteremia in Lebanon., (© 2024. The Author(s).)
- Published
- 2024
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