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6 results on '"Tomasotos V."'

1. Candidaemia with uncommon Candida species: Predisposing factors, outcome, antifungal susceptibility, and implications for management.

Author

McBride J., Chen S.C.A., Marriott D., Playford E.G., Nguyen Q., Ellis D., Meyer W., Sorrell T.C., Slavin M., McCormack J., Walmsley K., Looke D., Johnson B., Nimmo G., Playford G., Drummond D., Forgan Smith R., Preston E., Allworth A., Faoagali J., Gerns N., Botes J., Cherian S., Robson J., Vohra R., Norton R., Coulter C., O'Kane G., Robb D., Gottlieb T., Chambers I., DeWit D., Carroll M., Dobson P., Ferguson J., Tierney L., Jozwiak F., Munro R., Tomasotos V., Pickles R., Holland J., Groenwad F., Hale K., Watson M., Vaz R., Hardiman R., Baleriola C., Ryan S., Pritchard R., Weeks K., Benn R., Lawrence R., Taylor P., Lindstrom S., Harkness J., Palasanthrian P., Grant R., McPetrie R., Johnson R., Halliday C., Maszewska K., Dennis N., Newton P., Franklin C., Morrisey O., Spelman D., Wesselingh S., Speed B., Hellsten J., Mayall B., Russell J., Broughton S., Woolley I., Coloe S., Sherman A., Korman T., Graves S., Huysmans M., Gordon D., Rowlands K., Shaw D., Ritchie B., Handkle R., Beaman M., Chiam A., McCarthy J., Heath C., Altmann S., Arthur I., Speers D., Cox E., Cooley L., McGregor A., Currie B., Lum G., Fisher D., Collignon P., Roberts J., Watson A., McBride J., Chen S.C.A., Marriott D., Playford E.G., Nguyen Q., Ellis D., Meyer W., Sorrell T.C., Slavin M., McCormack J., Walmsley K., Looke D., Johnson B., Nimmo G., Playford G., Drummond D., Forgan Smith R., Preston E., Allworth A., Faoagali J., Gerns N., Botes J., Cherian S., Robson J., Vohra R., Norton R., Coulter C., O'Kane G., Robb D., Gottlieb T., Chambers I., DeWit D., Carroll M., Dobson P., Ferguson J., Tierney L., Jozwiak F., Munro R., Tomasotos V., Pickles R., Holland J., Groenwad F., Hale K., Watson M., Vaz R., Hardiman R., Baleriola C., Ryan S., Pritchard R., Weeks K., Benn R., Lawrence R., Taylor P., Lindstrom S., Harkness J., Palasanthrian P., Grant R., McPetrie R., Johnson R., Halliday C., Maszewska K., Dennis N., Newton P., Franklin C., Morrisey O., Spelman D., Wesselingh S., Speed B., Hellsten J., Mayall B., Russell J., Broughton S., Woolley I., Coloe S., Sherman A., Korman T., Graves S., Huysmans M., Gordon D., Rowlands K., Shaw D., Ritchie B., Handkle R., Beaman M., Chiam A., McCarthy J., Heath C., Altmann S., Arthur I., Speers D., Cox E., Cooley L., McGregor A., Currie B., Lum G., Fisher D., Collignon P., Roberts J., and Watson A.

Abstract

The risk factors for and clinical features of bloodstream infection with uncommon Candida spp. (species other than C. albicans, C. glabrata, C. parapsilosis, C. tropicals and C. krusei) are incompletely defined. To identify clinical variables associated with these species that might guide management, 57 cases of candidaemia resulting from uncommon Candida spp. were analysed in comparison with 517 episodes of Candida albicans candidaemia (2001-2004). Infection with uncommon Candida spp. (5.3% of candidaemia cases), as compared with C. albicans candidaemia, was significantly more likely to be outpatient-acquired than inpatient-acquired (15 of 57 vs. 65 of 517 episodes, p0.01). Prior exposure to fluconazole was uncommon (n =1). Candida dubliniensis was the commonest species (n =22, 39%), followed by Candida guilliermondii (n = 11, 19%) and Candida lusitaniae (n = 7, 12%). C. dubliniensis candidaemia was independently associated with recent intravenous drug use (p0.01) and chronic liver disease (p0.03), and infection with species other than C. dubliniensis was independently associated with age <65 years (p0.02), male sex (p0.03) and human immunodeficiency virus infection (p0.05). Presence of sepsis at diagnosis and crude 30-day mortality rates were similar for C. dubliniensis-related, non- C. dubliniensis-related and C. albicans-related candidaemia. Haematological malignancy was the commonest predisposing factor in C. guilliermondii (n = 3, 27%) and C. lusitaniae (n = 3, 43%) candidaemia. The 30-day mortality rate of C. lusitaniae candidaemia was higher than the overall death rate for all uncommon Candida spp. (42.9% vs. 25%, not significant). All isolates were susceptible to amphotericin.B, voriconazole, posaconazole, and caspofungin; five strains (9%) had fluconazole MIC values of 16-32 mg/L. Candidaemia due to uncommon Candida spp. is emerging among hospital outpatients; certain clinical variables may assist in recognition of this entity. © 2009 The Authors Journal c

Published
2012

2. Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection.

Author

McGregor A., Cooley L., Cox E., Franklin C., Korman T., Morrissey O., Spelman D., Speed B., Boan P., Dyer J., Gardam D., McLennan D., Murray R., Pryce T., Heath C.H., Slavin M.A., Sorrell T.C., Handke R., Harun A., Phillips M., Nguyen Q., Delhaes L., Ellis D., Meyer W., Chen S.C.A., Collignon P., Benn R., Chambers I., Dennis N., DeWit D., Ferguson J., Gosbell I., Gottlieb T., Halliday C., Holland J., Kesson A., Lawrence R., Marriott D., Newton P., Palasanthrian P., Pickles R., Pritchard B., Tierney L., Tomasotos V., Vaz R., Weeks K., Currie B., Allworth A., Coulter C., Faoagali J., Johnson B., Looke D., McCormack J., Nimmo G., O'Kane G., Playford E.G., Robson J., Rowlands K., Shaw D., McGregor A., Cooley L., Cox E., Franklin C., Korman T., Morrissey O., Spelman D., Speed B., Boan P., Dyer J., Gardam D., McLennan D., Murray R., Pryce T., Heath C.H., Slavin M.A., Sorrell T.C., Handke R., Harun A., Phillips M., Nguyen Q., Delhaes L., Ellis D., Meyer W., Chen S.C.A., Collignon P., Benn R., Chambers I., Dennis N., DeWit D., Ferguson J., Gosbell I., Gottlieb T., Halliday C., Holland J., Kesson A., Lawrence R., Marriott D., Newton P., Palasanthrian P., Pickles R., Pritchard B., Tierney L., Tomasotos V., Vaz R., Weeks K., Currie B., Allworth A., Coulter C., Faoagali J., Johnson B., Looke D., McCormack J., Nimmo G., O'Kane G., Playford E.G., Robson J., Rowlands K., and Shaw D.

Abstract

Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence >=15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum. © 2009 The Authors Journal compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases.

Published
2012

3. Active surveillance for candidemia, Australia.

Author

Watson M., Walmsley K., Looke D., Johnson B., Nimmo G., Drummond D., Forgan-Smith R., Preston E., Allworth A., Faoagali J., Gerns N., Botes J., Cherian S., Robson J., Vohra R., Norton R., O'Kane G., Robb D., Gottlieb T., Chambers I., DeWit D., Carroll M., Dobson P., Ferguson J., Tierney L., Jozwiak F., Munro R., Tomasotos V., Pickles R., Holland J., Groenwald F., Hale K., Vaz R., Hardiman R., Baleriola C., Ryan S., Pritchard R., Weeks K., Benn R., Adams N., Lawrence R., Taylor P., Lindstrom S., Harkness J., Palasanthrian P., Grant R., McPetrie R., Johnson R., Halliday C., Maszewska K., Lee O.C., Meyer W., Dennis N., Newton P., Franklin C., Morrisey O., Spelman D., Wesselingh S., Speed B., Hellsten J., Mayall B., Russell J., Broughton S., Woolley I., Coloe S., Korman T., Graves S., Huysmans M., Sherman A., Gordon D., Rowlands K., Shaw D., Ferguson W., Ritchie B., Handke R., Beaman M., Chiam A., McCarthy J., Heath C., Altmann S., Arthur I., Speers D., Cox E., Cooley L., McGregor A., Currie B., Lum G., Fisher D., McBride J., Chen S., Slavin M., Nguyen Q., Marriott D., Playford E.G., Ellis D., Sorrell T., Coulter C., McCormack J., Watson M., Walmsley K., Looke D., Johnson B., Nimmo G., Drummond D., Forgan-Smith R., Preston E., Allworth A., Faoagali J., Gerns N., Botes J., Cherian S., Robson J., Vohra R., Norton R., O'Kane G., Robb D., Gottlieb T., Chambers I., DeWit D., Carroll M., Dobson P., Ferguson J., Tierney L., Jozwiak F., Munro R., Tomasotos V., Pickles R., Holland J., Groenwald F., Hale K., Vaz R., Hardiman R., Baleriola C., Ryan S., Pritchard R., Weeks K., Benn R., Adams N., Lawrence R., Taylor P., Lindstrom S., Harkness J., Palasanthrian P., Grant R., McPetrie R., Johnson R., Halliday C., Maszewska K., Lee O.C., Meyer W., Dennis N., Newton P., Franklin C., Morrisey O., Spelman D., Wesselingh S., Speed B., Hellsten J., Mayall B., Russell J., Broughton S., Woolley I., Coloe S., Korman T., Graves S., Huysmans M., Sherman A., Gordon D., Rowlands K., Shaw D., Ferguson W., Ritchie B., Handke R., Beaman M., Chiam A., McCarthy J., Heath C., Altmann S., Arthur I., Speers D., Cox E., Cooley L., McGregor A., Currie B., Lum G., Fisher D., McBride J., Chen S., Slavin M., Nguyen Q., Marriott D., Playford E.G., Ellis D., Sorrell T., Coulter C., and McCormack J.

Abstract

Population-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. Annual overall and hospital-specific incidences were 1.81/100,000 and 0.21/1,000 separations (completed admissions), respectively. Predisposing factors included malignancy (32.1%), indwelling vascular catheters (72.6%), use of antimicrobial agents (77%), and surgery (37.1%). Of 919 episodes, 81.5% were inpatient healthcare associated (IHCA), 11.6% were outpatient healthcare associated (OHCA), and 6.9% were community acquired (CA). Concomitant illnesses and risk factors were similar in IHCA and OHCA candidemia. IHCA candidemia was associated with sepsis at diagnosis (p<0.001), death <=30 days after infection (p<0.001), and prolonged hospital admission (p<0.001). Non-Candida albicans species (52.7%) caused 60.5% of cases acquired outside hospitals and 49.9% of IHCA candidemia (p = 0.02). The 30-day death rate was 27.7% in those >=65 years of age. Adult critical care stay, sepsis syndrome, and corticosteroid therapy were associated with the greatest risk for death. Systematic epidemiologic studies that use standardized definitions for IHCA, OHCA, and CA candidemia are indicated.

Published
2012

4. Molecular typing of Australian Scedosporium isolates showing genetic variability and numerous S. aurantiacum.

Author

McGregor A., Korman T., Morrissey O., Spelman D., Speed B., Sheorey H., Boan P., Dyer J., Gardam D., McLennan D., Murray R., Pryce T., Delhaes L., Harun A., Chen S.C.A., Nguyen Q., Slavin M., Heath C.H., Maszewska K., Halliday C., Robert V., Sorrell T.C., Meyer W., Collignon P., Benn R., Chambers I., Dennis N., Dewit D., Ferguson J., Gosbell I., Gottlieb T., Holland J., Kesson A., Lawrence R., Marriott D., Newton P., Palasanthrian P., Pickles R., Pritchard R., Tierney L., Tomasotos V., Vaz R., Weeks K., Allworth A., Coulter C., Faoagali J., Johnson B., Looke D., McCormack J., Nimmo G., O'Kane G., Playford E.G., Robson J., Ellis D., Handke R., Rowlands K., Shaw D., Cooley L., Cox E., Franklin C., Joseph C., McGregor A., Korman T., Morrissey O., Spelman D., Speed B., Sheorey H., Boan P., Dyer J., Gardam D., McLennan D., Murray R., Pryce T., Delhaes L., Harun A., Chen S.C.A., Nguyen Q., Slavin M., Heath C.H., Maszewska K., Halliday C., Robert V., Sorrell T.C., Meyer W., Collignon P., Benn R., Chambers I., Dennis N., Dewit D., Ferguson J., Gosbell I., Gottlieb T., Holland J., Kesson A., Lawrence R., Marriott D., Newton P., Palasanthrian P., Pickles R., Pritchard R., Tierney L., Tomasotos V., Vaz R., Weeks K., Allworth A., Coulter C., Faoagali J., Johnson B., Looke D., McCormack J., Nimmo G., O'Kane G., Playford E.G., Robson J., Ellis D., Handke R., Rowlands K., Shaw D., Cooley L., Cox E., Franklin C., and Joseph C.

Abstract

One hundred clinical isolates from a prospective nationwide study of scedosporiosis in Australia (2003-2005) and 46 additional isolates were genotyped by internal transcribed spacer-restriction fragment length polymorphism (ITS-RFLP) analysis, ITS sequencing, and M13 PCR fingerprinting. ITS-RFLP and PCR fingerprinting identified 3 distinct genetic groups. The first group corresponded to Scedosporium prolificans (n = 83), and the other 2 comprised isolates previously identified as S. apiospermum: one of these corresponded to S. apiospermum (n = 33) and the other to the newly described species S. aurantiacum (n = 30). Intraspecies variation was highest for S. apiospermum (58%), followed by S. prolificans (45%) and S. aurantiacum (28%) as determined by PCR fingerprinting. ITS sequence variation of 2.2% was observed among S. apiospermum isolates. No correlation was found between genotype of strains and their geographic origin, body site from which they were cultured, or colonization versus invasive disease. Twelve S. prolificans isolates from 2 suspected case clusters were examined by amplified fragment length polymorphism analysis. No specific clusters were confirmed.

Published
2008

5. Active surveillance for candidemia, Australia

Author

Chen, S., Slavin, M., Nguyen, Q., Marriott, D., Playford, E. G., Ellis, D., Tania Sorrell, Mcbride, J., Coulter, C., Mccormack, J., Walmsley, K., Looke, D., Johnson, B., Nimmo, G., Drummond, D., Forgan-Smith, R., Preston, E., Allworth, A., Faoagali, J., Gerns, N., Botes, J., Cherian, S., Robson, J., Vohra, R., Norton, R., O Kane, G., Robb, D., Gottlieb, T., Chambers, I., Dewit, D., Carroll, M., Dobson, P., Ferguson, J., Graves, S., Tierney, L., Jozwiak, F., Munro, R., Tomasotos, V., Pickles, R., Holland, J., Groenwald, F., Hale, K., Watson, M., Vaz, R., Hardiman, R., Baleriola, C., Ryan, S., Pritchard, R., Weeks, K., Benn, R., Adams, N., Lawrence, R., Taylor, P., Lindstrom, S., Harkness, J., Palasanthrian, P., Grant, R., Mcpetrie, R., Johnson, R., Halliday, C., Maszewska, K., Lee, O. C., Meyer, W., Dennis, N., Newton, P., Franklin, C., Morrisey, O., Spelman, D., Wesselingh, S., Speed, B., Hellsten, J., Mayall, B., Russell, J., Broughton, S., Woolley, I., Coloe, S., Sherman, A., Korman, T., Huysmans, M., Gordon, D., Rowlands, K., Shaw, D., Ferguson, W., Ritchie, B., Handke, R., Beaman, M., Chiam, A., Mccarthy, J., Heath, C., Altmann, S., Arthur, I., Speers, D., Cox, E., Cooley, L., Mcgregor, A., Currie, B., Lum, G., and Fisher, D.

6. Molecular typing of Australian Scedosporium isolates showing genetic variability and numerous S. aurantiacum

Author

Delhaes, L., Harun, A., Chen, S. C. A., Nguyen, Q., Slavin, M., Heath, C. H., Maszewska, K., Halliday, C., Robert, V., Sorrell, T. C., Meyer, W., Collignon, P., Benn, R., Chambers, I., Chen, S., Dennis, N., Dewit, D., Ferguson, J., Iain Gosbell, Gottlieb, T., Holland, J., Kesson, A., Lawrence, R., Marriott, D., Newton, P., Palasanthrian, P., Pickles, R., Pritchard, R., Sorrell, T., Tierney, L., Tomasotos, V., Vaz, R., Weeks, K., Allworth, A., Coulter, C., Faoagali, J., Johnson, B., Looke, D., Mccormack, J., Nimmo, G., O Kane, G., Playford, E. G., Robson, J., Ellis, D., Handke, R., Rowlands, K., Shaw, D., Cooley, L., Cox, E., Mcgregor, A., Franklin, C., Joseph, C., Korman, T., Morrissey, O., Spelman, D., Speed, B., Sheorey, H., Boan, P., Dyer, J., Heath, C., Gardam, D., Mclennan, D., Murray, R., and Pryce, T.

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