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Abstract Background Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring. Objective We sought to assess the association between cardiac-related genes and whole-heart myocardial mechanics or morphometrics in nonischemic dilated cardiomyopathy (NIDCM). Methods It was a prospective study consisting of patients with NIDCM. All patients were referred for genetic testing and a genetic analysis was performed using Illumina NextSeq 550 and a commercial gene capture panel of 233 genes (Systems Genomics, Cardiac-GeneSGKit®). It was analyzed whether there are significant differences in clinical, two-dimensional (2D) echocardiographic, and magnetic resonance imaging (MRI) parameters between patients with the genes variants and those without. 2D echocardiography and MRI were used to analyze myocardial mechanics and morphometrics. Results The study group consisted of 95 patients with NIDCM and the average age was 49.7 ± 10.5. All echocardiographic and MRI parameters of myocardial mechanics (left ventricular ejection fraction 28.4 ± 8.7 and 30.7 ± 11.2, respectively) were reduced and all values of cardiac chambers were increased (left ventricular end-diastolic diameter 64.5 ± 5.9 mm and 69.5 ± 10.7 mm, respectively) in this group. It was noticed that most cases of whole-heart myocardial mechanics and morphometrics differences between patients with and without gene variants were in the genes GATAD1, LOX, RASA1, KRAS, and KRIT1. These genes have not been previously linked to DCM. It has emerged that KRAS and KRIT1 genes were associated with worse whole-heart mechanics and enlargement of all heart chambers. GATAD1, LOX, and RASA1 genes variants showed an association with better cardiac function and morphometrics parameters. It might be that these variants alone do not influence disease development enough to be selective in human evolution. Conclusions Combined variants in previously unreported genes related to DCM might play a significant role in affecting clinical, morphometrics, or myocardial mechanics parameters.

Text simplification reduces the complexity of text while preserving essential information, thus making it more accessible to a broad range of readers, including individuals with cognitive disorders, non-native speakers, children, and the general public. In this paper, we present experiments on text simplification for the Lithuanian language, aiming to simplify administrative texts to a Plain Language level. We fine-tuned mT5 and mBART models for this task and evaluated the effectiveness of ChatGPT as well. We assessed simplification results via both quantitative metrics and qualitative evaluation. Our findings indicated that mBART performed the best as it achieved the best scores across all evaluation metrics. The qualitative analysis further supported these findings. ChatGPT experiments showed that it responded quite well to a short and simple prompt to simplify the given text; however, it ignored most of the rules given in a more elaborate prompt. Finally, our analysis revealed that BERTScore and ROUGE aligned moderately well with human evaluations, while BLEU and readability scores indicated lower or even negative correlations

Financial distress identification remains an essential topic in the scientific literature due to its importance for society and the economy. The advancements in information technology and the escalating volume of stored data have led to the emergence of financial distress that transcends the realm of financial statements and its’ indicators (ratios). The feature space could be expanded by incorporating new perspectives on feature data categories such as macroeconomics, sectors, social, board, management, judicial incident, etc. However, the increased dimensionality results in sparse data and overfitted models. This study proposes a new approach for efficient financial distress classification assessment by combining dimensionality reduction and machine learning techniques. The proposed framework aims to identify a subset of features leading to the minimization of the loss function describing the financial distress in an enterprise. During the study, 15 dimensionality reduction techniques with different numbers of features and 17 machine-learning models were compared. Overall, 1,432 experiments were performed using Lithuanian enterprise data covering the period from 2015 to 2022. Results revealed that the artificial neural network (ANN) model with 30 ranked features identified using the Random Forest mean decreasing Gini (RF_MDG) feature selection technique provided the highest AUC score. Moreover, this study has introduced a novel approach for feature extraction, which could improve financial distress classification models.

ObjectiveThis study aimed to analyze the association between the behavior of cancer patients, measured using passively and continuously generated data streams from smartphone sensors (as in digital phenotyping), and perceived fear of COVID-19 and COVID-19 vaccination status.MethodsA total of 202 patients with different cancer types and undergoing various treatments completed the COVID-19 Fears Questionnaire for Chronic Medical Conditions, and their vaccination status was evaluated. Patients’ behaviors were monitored using a smartphone application that passively and continuously captures high-resolution data from personal smartphone sensors. In all, 107 patients were monitored for at least 2 weeks. The study was conducted between August 2022 and August 2023. Distributions of clinical and demographical parameters between fully vaccinated, partially vaccinated, and unvaccinated patients were compared using the Chi-squared test. The fear of COVID-19 among the groups was compared using the Mann–Whitney and the Kruskal–Wallis criteria. Trajectories of passively generated data were compared as a function of fear of COVID-19 and COVID-19 vaccination status using local polynomial regression.ResultsIn total, 202 patients were included in the study. Most patients were fully (71%) or partially (13%) vaccinated and 16% of the patients were unvaccinated for COVID-19. Fully vaccinated or unvaccinated patients reported greater fear of COVID-19 than partially vaccinated patients. Fear of COVID-19 was higher in patients being treated with biological therapy. Patients who reported a higher fear of COVID-19 spent more time at home, visited places at shorter distances from home, and visited fewer places of interest (POI). Fully or partially vaccinated patients visited more POI than unvaccinated patients. Local polynomial regression using passively generated smartphone sensor data showed that, although at the beginning of the study, all patients had a similar number of POI, after 1 week, partially vaccinated patients had an increased number of POI, which later remained, on average, around four POI per day. Meanwhile, fully vaccinated or unvaccinated patients had a similar trend of POI and it did not exceed three visits per day during the entire treatment period.ConclusionThe COVID-19 pandemic continues to have an impact on the behavior of cancer patients even after the termination of the global pandemic. A higher perceived fear of COVID-19 was associated with less movement, more time spent at home, less time spent outside of home, and a lower number of visited places. Unvaccinated patients visited fewer places and were moving less overall during a 14-week follow-up as compared to vaccinated patients.

BackgroundTimely recognition of cancer progression and treatment complications is important for treatment guidance. Digital phenotyping is a promising method for precise and remote monitoring of patients in their natural environments by using passively generated data from sensors of personal wearable devices. Further studies are needed to better understand the potential clinical benefits of digital phenotyping approaches to optimize care of patients with cancer. ObjectiveWe aim to evaluate whether passively generated data from smartphone sensors are feasible for remote monitoring of patients with cancer to predict their disease trajectories and patient-centered health outcomes. MethodsWe will recruit 200 patients undergoing treatment for cancer. Patients will be followed up for 6 months. Passively generated data by sensors of personal smartphone devices (eg, accelerometer, gyroscope, GPS) will be continuously collected using the developed LAIMA smartphone app during follow-up. We will evaluate (1) mobility data by using an accelerometer (mean time of active period, mean time of exertional physical activity, distance covered per day, duration of inactive period), GPS (places of interest visited daily, hospital visits), and gyroscope sensors and (2) sociability indices (frequency of duration of phone calls, frequency and length of text messages, and internet browsing time). Every 2 weeks, patients will be asked to complete questionnaires pertaining to quality of life (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC QLQ-C30]), depression symptoms (Patient Health Questionnaire-9 [PHQ-9]), and anxiety symptoms (General Anxiety Disorder-7 [GAD-7]) that will be deployed via the LAIMA app. Clinic visits will take place at 1-3 months and 3-6 months of the study. Patients will be evaluated for disease progression, cancer and treatment complications, and functional status (Eastern Cooperative Oncology Group) by the study oncologist and will complete the questionnaire for evaluating quality of life (EORTC QLQ-C30), depression symptoms (PHQ-9), and anxiety symptoms (GAD-7). We will examine the associations among digital, clinical, and patient-reported health outcomes to develop prediction models with clinically meaningful outcomes. ResultsAs of July 2023, we have reached the planned recruitment target, and patients are undergoing follow-up. Data collection is expected to be completed by September 2023. The final results should be available within 6 months after study completion. ConclusionsThis study will provide in-depth insight into temporally and spatially precise trajectories of patients with cancer that will provide a novel digital health approach and will inform the design of future interventional clinical trials in oncology. Our findings will allow a better understanding of the potential clinical value of passively generated smartphone sensor data (digital phenotyping) for continuous and real-time monitoring of patients with cancer for treatment side effects, cancer complications, functional status, and patient-reported outcomes as well as prediction of disease progression or trajectories. International Registered Report Identifier (IRRID)PRR1-10.2196/49096

The study presents a systematic review of 232 studies on various aspects of the use of artificial intelligence methods for identification of financial distress (such as bankruptcy or insolvency). We follow the guidelines of the PRISMA methodology for performing the systematic reviews. The study discusses bankruptcy-related financial datasets, data imbalance, feature dimensionality reduction in financial datasets, financial distress prediction, data pre-processing issues, non-financial indicators, frequently used machine-learning methods, performance evolution metrics, and other related issues of machine-learning-based workflows. The study findings revealed the necessity of data balancing, dimensionality reduction techniques in data preprocessing, and allow researchers to identify new research directions that have not been analyzed yet.

Pedestrian occurrences in images and videos must be accurately recognized in a number of applications that may improve the quality of human life. Radar can be used to identify pedestrians. When distinct portions of an object move in front of a radar, micro-Doppler signals are produced that may be utilized to identify the object. Using a deep-learning network and time–frequency analysis, we offer a method for classifying pedestrians and animals based on their micro-Doppler radar signature features. Based on these signatures, we employed a convolutional neural network (CNN) to recognize pedestrians and animals. The proposed approach was evaluated on the MAFAT Radar Challenge dataset. Encouraging results were obtained, with an AUC (Area Under Curve) value of 0.95 on the public test set and over 0.85 on the final (private) test set. The proposed DNN architecture, in contrast to more common shallow CNN architectures, is one of the first attempts to use such an approach in the domain of radar data. The use of the synthetic radar data, which greatly improved the final result, is the other novel aspect of our work.

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Due to the fast pace of life and online communications and the prevalence of English and the QWERTY keyboard, people tend to forgo using diacritics, make typographical errors (typos) when typing in other languages. Restoring diacritics and correcting spelling is important for proper language use and the disambiguation of texts for both humans and downstream algorithms. However, both of these problems are typically addressed separately: the state-of-the-art diacritics restoration methods do not tolerate other typos, but classical spellcheckers also cannot deal adequately with all the diacritics missing.In this work, we tackle both problems at once by employing the newly-developed universal ByT5 byte-level seq2seq transformer model that requires no language-specific model structures. For a comparison, we perform diacritics restoration on benchmark datasets of 12 languages, with the addition of Lithuanian. The experimental investigation proves that our approach is able to achieve results (>98%) comparable to the previous state-of-the-art, despite being trained less and on fewer data. Our approach is also able to restore diacritics in words not seen during training with >76% accuracy. Our simultaneous diacritics restoration and typos correction approach reaches >94% alpha-word accuracy on the 13 languages. It has no direct competitors and strongly outperforms classical spell-checking or dictionary-based approaches. We also demonstrate all the accuracies to further improve with more training. Taken together, this shows the great real-world application potential of our suggested methods to more data, languages, and error classes.

This survey is an effort to provide a research repository and a useful reference for researchers to guide them when planning to develop new Nature-inspired Algorithms tailored to solve Feature Selection problems (NIAs-FS). We identified and performed a thorough literature review in three main streams of research lines: Feature selection problem, optimization algorithms, particularly, meta-heuristic algorithms, and modifications applied to NIAs to tackle the FS problem. We provide a detailed overview of 156 different articles about NIAs modifications for tackling FS. We support our discussions by analytical views, visualized statistics, applied examples, open-source software systems, and discuss open issues related to FS and NIAs. Finally, the survey summarizes the main foundations of NIAs-FS with approximately 34 different operators investigated. The most popular operator is chaotic maps. Hybridization is the most widely used modification technique. There are three types of hybridization: Integrating NIA with another NIA, integrating NIA with a classifier, and integrating NIA with a classifier. The most widely used hybridization is the one that integrates a classifier with the NIA. Microarray and medical applications are the dominated applications where most of the NIA-FS are modified and used. Despite the popularity of the NIAs-FS, there are still many areas that need further investigation.

Human activity recognition (HAR) plays a vital role in different real-world applications such as in tracking elderly activities for elderly care services, in assisted living environments, smart home interactions, healthcare monitoring applications, electronic games, and various human–computer interaction (HCI) applications, and is an essential part of the Internet of Healthcare Things (IoHT) services. However, the high dimensionality of the collected data from these applications has the largest influence on the quality of the HAR model. Therefore, in this paper, we propose an efficient HAR system using a lightweight feature selection (FS) method to enhance the HAR classification process. The developed FS method, called GBOGWO, aims to improve the performance of the Gradient-based optimizer (GBO) algorithm by using the operators of the grey wolf optimizer (GWO). First, GBOGWO is used to select the appropriate features; then, the support vector machine (SVM) is used to classify the activities. To assess the performance of GBOGWO, extensive experiments using well-known UCI-HAR and WISDM datasets were conducted. Overall outcomes show that GBOGWO improved the classification accuracy with an average accuracy of 98%.

One of the first signs of Alzheimer’s disease (AD) is mild cognitive impairment (MCI), in which there are small variants of brain changes among the intermediate stages. Although there has been an increase in research into the diagnosis of AD in its early levels of developments lately, brain changes, and their complexity for functional magnetic resonance imaging (fMRI), makes early detection of AD difficult. This paper proposes a deep learning-based method that can predict MCI, early MCI (EMCI), late MCI (LMCI), and AD. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) fMRI dataset consisting of 138 subjects was used for evaluation. The finetuned ResNet18 network achieved a classification accuracy of 99.99%, 99.95%, and 99.95% on EMCI vs. AD, LMCI vs. AD, and MCI vs. EMCI classification scenarios, respectively. The proposed model performed better than other known models in terms of accuracy, sensitivity, and specificity.

We propose a deep learning method based on the Region Based Convolutional Neural Networks (R-CNN) architecture for the evaluation of sperm head motility in human semen videos. The neural network performs the segmentation of sperm heads, while the proposed central coordinate tracking algorithm allows us to calculate the movement speed of sperm heads. We have achieved 91.77% (95% CI, 91.11–92.43%) accuracy of sperm head detection on the VISEM (A Multimodal Video Dataset of Human Spermatozoa) sperm sample video dataset. The mean absolute error (MAE) of sperm head vitality prediction was 2.92 (95% CI, 2.46–3.37), while the Pearson correlation between actual and predicted sperm head vitality was 0.969. The results of the experiments presented below will show the applicability of the proposed method to be used in automated artificial insemination workflow.

We present a model for digital neural impairment screening and self-assessment, which can evaluate cognitive and motor deficits for patients with symptoms of central nervous system (CNS) disorders, such as mild cognitive impairment (MCI), Parkinson’s disease (PD), Huntington’s disease (HD), or dementia. The data was collected with an Android mobile application that can track cognitive, hand tremor, energy expenditure, and speech features of subjects. We extracted 238 features as the model inputs using 16 tasks, 12 of them were based on a self-administered cognitive testing (SAGE) methodology and others used finger tapping and voice features acquired from the sensors of a smart mobile device (smartphone or tablet). Fifteen subjects were involved in the investigation: 7 patients with neurological disorders (1 with Parkinson’s disease, 3 with Huntington’s disease, 1 with early dementia, 1 with cerebral palsy, 1 post-stroke) and 8 healthy subjects. The finger tapping, SAGE, energy expenditure, and speech analysis features were used for neural impairment evaluations. The best results were achieved using a fusion of 13 classifiers for combined finger tapping and SAGE features (96.12% accuracy), and using bidirectional long short-term memory (BiLSTM) (94.29% accuracy) for speech analysis features.