849 results on '"Tomada, A."'
Search Results
2. Demonstrating a long-coherence dual-rail erasure qubit using tunable transmons
- Author
-
Levine, Harry, Haim, Arbel, Hung, Jimmy S. C., Alidoust, Nasser, Kalaee, Mahmoud, DeLorenzo, Laura, Wollack, E. Alex, Arrangoiz-Arriola, Patricio, Khalajhedayati, Amirhossein, Sanil, Rohan, Moradinejad, Hesam, Vaknin, Yotam, Kubica, Aleksander, Hover, David, Aghaeimeibodi, Shahriar, Alcid, Joshua Ari, Baek, Christopher, Barnett, James, Bawdekar, Kaustubh, Bienias, Przemyslaw, Carson, Hugh, Chen, Cliff, Chen, Li, Chinkezian, Harut, Chisholm, Eric M., Clifford, Andrew, Cosmic, R., Crisosto, Nicole, Dalzell, Alexander M., Davis, Erik, D'Ewart, J. Mitch, Diez, Sandra, D'Souza, Nathan, Dumitrescu, Philipp T., Elkhouly, Essam, Fang, Michael, Fang, Yawen, Flammia, Steven T., Fling, Matthew J., Garcia, Gabriel, Gharzai, M. Kabeer, Gorshkov, Alexey V., Gray, Mason J., Grimberg, Sebastian, Grimsmo, Arne L., Hann, Connor T., He, Yuan, Heidel, Steven, Howell, Sean, Hunt, Matthew, Iverson, Joseph K., Jarrige, Ignace, Jiang, Liang, Jones, William M., Karabalin, Rassul, Karalekas, Peter J., Keller, Andrew J., Lasi, Davide, Lee, Menyoung, Ly, Victor, MacCabe, Gregory S., Mahuli, Neha, Marcaud, Guillaume, Matheny, Matthew H., McArdle, Sam, McCabe, Gavin, Merton, Gabe, Miles, Cody, Milsted, Ashley, Mishra, Anurag, Moncelsi, Lorenzo, Naghiloo, Mahdi, Noh, Kyungjoo, Oblepias, Eric, Ortuno, Gerson, Owens, John Clai, Pagdilao, Jason, Panduro, Ashley, Paquette, J. -P., Patel, Rishi N., Peairs, Gregory A., Perello, David J., Peterson, Eric C., Ponte, Sophia, Putterman, Harald, Refael, Gil, Reinhold, Philip, Resnick, Rachel, Reyna, Omar A., Rodriguez, Roberto, Rose, Jefferson, Rubin, Alex H., Runyan, Marc, Ryan, Colm A., Sahmoud, Abdulrahman, Scaffidi, Thomas, Shah, Bhavik, Siavoshi, Salome, Sivarajah, Prasahnt, Skogland, Trenton, Su, Chun-Ju, Swenson, Loren J., Sylvia, Jared, Teo, Stephanie M., Tomada, Astrid, Torlai, Giacomo, Wistrom, Mark, Zhang, Kailing, Zuk, Ido, Clerk, Aashish A., Brandão, Fernando G. S. L., Retzker, Alex, and Painter, Oskar
- Subjects
Quantum Physics - Abstract
Quantum error correction with erasure qubits promises significant advantages over standard error correction due to favorable thresholds for erasure errors. To realize this advantage in practice requires a qubit for which nearly all errors are such erasure errors, and the ability to check for erasure errors without dephasing the qubit. We demonstrate that a "dual-rail qubit" consisting of a pair of resonantly coupled transmons can form a highly coherent erasure qubit, where transmon $T_1$ errors are converted into erasure errors and residual dephasing is strongly suppressed, leading to millisecond-scale coherence within the qubit subspace. We show that single-qubit gates are limited primarily by erasure errors, with erasure probability $p_\text{erasure} = 2.19(2)\times 10^{-3}$ per gate while the residual errors are $\sim 40$ times lower. We further demonstrate mid-circuit detection of erasure errors while introducing $< 0.1\%$ dephasing error per check. Finally, we show that the suppression of transmon noise allows this dual-rail qubit to preserve high coherence over a broad tunable operating range, offering an improved capacity to avoid frequency collisions. This work establishes transmon-based dual-rail qubits as an attractive building block for hardware-efficient quantum error correction., Comment: 9+13 pages, 16 figures
- Published
- 2023
- Full Text
- View/download PDF
3. Anastomotic Techniques for Crohn’s Surgery
- Author
-
Spinelli, Antonino, Paoluzzi Tomada, Elisa, Evans, Martyn, editor, Davies, Mark, editor, Harries, Rhiannon, editor, and Beynon, John, editor
- Published
- 2024
- Full Text
- View/download PDF
4. The efficacy of penile duplex ultrasound in erectile dysfunction management decision-making: facing the opinion leader
- Author
-
Andrea Cocci, Marta Pezzoli, Mattia Lo Re, David Ralph, Nim Christopher, Daniar Osmonov, Carlo Bettocchi, Rados Djinovic, Gabriele Antonini, Laurence Levine, Juan Ignacio Martínez Salamanca, Javier Romero Otero, Paulo Egydio, Ignacio Moncada Iribarren, Georgios Hatzichristodoulou, Paul Perito, Faix Antoine, Hyun Jun Park, Luigi Rolle, Ateş Kadıoğlu, Eduard Ruíz-Castañé, Koenraad Van Renterghem, Robert J Valenzuela, Steven K Wilson, Nuno Tomada, Marco Capece, and Marco Falcone
- Subjects
erectile dysfunction ,penile duplex ultrasound ,intracavernous injection ,Medicine (General) ,R5-920 - Abstract
Erectile dysfunction (ED) poses a significant challenge in clinical practice, necessitating accurate diagnostic strategies to distinguish between organic and psychogenic causes. Current guidelines advocate a comprehensive approach involving medical history, physical examination and blood tests, with second-level analyses like the intracavernous injection of vasoactive drugs (ICI test) and penile duplex ultrasound (PDU) reserved for specific cases. A survey involving 24 urologists experienced in ED was conducted to assess their opinions on the appropriateness of the ICI test and PDU in six clinical scenarios. Results were analyzed using pie charts, revealing varied preferences among experts. The responses indicated diverse viewpoints, with preferences for the ICI test or PDU depending on the patient’s age, comorbidities, response to phosphodiesterase type 5 inhibitors (PDE5i) and concomitant Peyronie’s disease. In some cases, a significant proportion of experts opted for neither test. The study highlights the lack of consensus among experts regarding the routine use of PDU in ED management. Despite its diagnostic capabilities, the clinical utility of PDU remains unclear, and its role may be more justified in certain populations with anatomical abnormalities or specific conditions. The need for rigorous research to determine the impact of PDU on ED management decision-making is emphasized.
- Published
- 2024
- Full Text
- View/download PDF
5. FairLex: A Multilingual Benchmark for Evaluating Fairness in Legal Text Processing
- Author
-
Chalkidis, Ilias, Pasini, Tommaso, Zhang, Sheng, Tomada, Letizia, Schwemer, Sebastian Felix, and Søgaard, Anders
- Subjects
Computer Science - Computation and Language - Abstract
We present a benchmark suite of four datasets for evaluating the fairness of pre-trained language models and the techniques used to fine-tune them for downstream tasks. Our benchmarks cover four jurisdictions (European Council, USA, Switzerland, and China), five languages (English, German, French, Italian and Chinese) and fairness across five attributes (gender, age, region, language, and legal area). In our experiments, we evaluate pre-trained language models using several group-robust fine-tuning techniques and show that performance group disparities are vibrant in many cases, while none of these techniques guarantee fairness, nor consistently mitigate group disparities. Furthermore, we provide a quantitative and qualitative analysis of our results, highlighting open challenges in the development of robustness methods in legal NLP., Comment: 9 pages, long paper at ACL 2022 proceedings
- Published
- 2022
6. Tuition Fee or Tuition Free? The Case of Public Higher Education in the Philippines
- Author
-
Tomada, Millicent, primary and Galido, Adrian, additional
- Published
- 2024
- Full Text
- View/download PDF
7. Mediterranean Diet and Male Fertility
- Author
-
Inês Tomada and Nuno Tomada
- Subjects
Mediterranean diet ,male fertility ,sperm quality parameters ,nutrition ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Diet has an impact on male reproductive potential, but few studies have focused on the specific impact of food groups or dietary patterns on fertility. Male reproductive health, as indicated by improved semen parameters and increased chances of conceiving, is associated with the Mediterranean diet, while the Western diet is considered a risk factor for male infertility. The potential mechanisms that may explain the impact of these diets on semen quality are still largely unknown. However, numerous studies suggest that nutritional interventions are crucial for the preservation and improvement of male fertility. This review aims to summarize the most recent evidence on the influence of components of the Mediterranean diet on sperm parameters. Unlike other risk factors, dietary modulation represents a great opportunity for improving overall health and can also be an important tool in recommendations for male reproductive health.
- Published
- 2023
- Full Text
- View/download PDF
8. Molecular genetic variability of Cryphonectria hypovirus 1 associated with Cryphonectria parasitica in South Tyrol (northern Italy)
- Author
-
Farooq Ahmad, Selena Tomada, Thanalai Poonsiri, and Sanja Baric
- Subjects
dsRNA viruses ,mycoviruses ,hypovirulence ,immunoassay ,RT-PCR ,chestnut blight ,Microbiology ,QR1-502 - Abstract
Cryphonectria hypovirus 1 (CHV-1) has been widely studied and used as a biocontrol agent because of its ability to infect the chestnut blight fungus, Cryphonectria parasitica, and to reduce its virulence. Knowledge about the hypovirus, its presence, and diversity is completely lacking in South Tyrol (northern Italy), which may obstruct biocontrol measures for chestnut blight based on CHV-1. This work aimed to study the occurrence of CHV-1 infecting C. parasitica in South Tyrol and to perform a genetic characterization of the hypovirus. In South Tyrol, CHV-1 was found to occur in 29.2% of the fungal isolates investigated, varying in frequency between different regions and chestnut stands. Twenty-three haplotypes based on partial cDNA (complementary DNA) sequences of open reading frame (ORF)-A and 30 haplotypes based on partial cDNA sequences of ORF-B were identified among 47 and 56 hypovirulent fungal isolates, respectively. Phylogenetic analysis showed that all the haplotypes belonged to the Italian subtype of CHV-1 and that they were closely related to the populations of Italy, Switzerland, Croatia and Slovenia. Evidence of recombination was not found in the sequences and point mutations were the main source of diversity. Overall, this study indicated that the prevalence of CHV-1 in South Tyrol is low compared to many other central and western European populations and determined a need to actively impose biocontrol measures. Using sequence analysis, we identified some variants of interest of CHV-1 that should be studied in detail for their potential use in biocontrol.
- Published
- 2024
- Full Text
- View/download PDF
9. Detector Technologies for CLIC
- Author
-
Hoffman, A. C. Abusleme, Parès, G., Fritzsch, T., Rothermund, M., Jansen, H., Krüger, K., Sefkow, F., Velyka, A., Schwandt, J., Perić, I., Emberger, L., Graf, C., Macchiolo, A., Simon, F., Szalay, M., van der Kolk, N., Abramowicz, H., Benhammou, Y., Borysov, O., Borysova, M., Joffe, A., Kananov, S., Levy, A., Levy, I., Eigen, G., Bugiel, R., Bugiel, S., Firlej, M., Fiutowski, T. A., Idzik, M., Moroń, J., Świentek, K. P., Terlecki, P., de Renstrom, P. Brückman, Turbiarz, B., Wojtoń, T., Zawiejski, L. K., Firu, E., Ghenescu, V., Neagu, A. T., Preda, T., Boyko, I., Nefedov, Yu., Rymbekova, A., Sapronov, A., Shelkov, G., Zhemchugov, A., Ruiz-Jimeno, A., Vila, I., Fullana, E., Fuster, J., Lopez, P. Gomis, Perelló, M., Villarejo, M. A., Vos, M., Alozy, J., Tehrani, N. Alipour, Arominski, D., Sune, R. Ballabriga, Boyer, F., Brondolin, E., Buckland, M., Campbell, M., Dannheim, D., Dette, K., Ramos, F. Duarte, Plaja, N. Egidos, Elsener, K., Fiergolski, A., Rojas, C. Fuentes, Grefe, C., Hynds, D., Klempt, W., Kremastiotis, I., Kröger, J., Kulis, S., Leogrande, E., Linssen, L., Cudie, X. Llopart, Lucaci-Timoce, A., Munker, M., Musa, L., Nürnberg, A., Nuiry, F. -X., Codina, E. Perez, Pernegger, H., Petrič, M., Pitters, F., Quast, T., Redford, S., Riedler, P., Roloff, P., Sailer, A., Santin, E., Schnoor, U., Sicking, E., Sielewicz, K., Simoniello, R., Snoeys, W., Spannagel, S., Sroka, S., Ström, R., Valerio, P., van Dam, S., van der Kraaij, E., Vǎnát, T., Viazlo, O., Pinto, M. Vicente Barreto, Weber, M. A., Williams, M., Wolters, K., Benoit, M., Iacobucci, G., Sultan, D M S, Bosley, R. R., Price, T., Watson, M. F., Watson, N. K., Winter, A. G., Goldstein, J., Green, S., Marshall, J. S., Thomson, M. A., Xu, B., Casse, G., Vossebeld, J., Coates, T., Salvatore, F., Repond, J., Xia, L., Kenney, C., and Tomada, A.
- Subjects
Physics - Instrumentation and Detectors - Abstract
The Compact Linear Collider (CLIC) is a high-energy high-luminosity linear electron-positron collider under development. It is foreseen to be built and operated in three stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. It offers a rich physics program including direct searches as well as the probing of new physics through a broad set of precision measurements of Standard Model processes, particularly in the Higgs-boson and top-quark sectors. The precision required for such measurements and the specific conditions imposed by the beam dimensions and time structure put strict requirements on the detector design and technology. This includes low-mass vertexing and tracking systems with small cells, highly granular imaging calorimeters, as well as a precise hit-time resolution and power-pulsed operation for all subsystems. A conceptual design for the CLIC detector system was published in 2012. Since then, ambitious R&D programmes for silicon vertex and tracking detectors, as well as for calorimeters have been pursued within the CLICdp, CALICE and FCAL collaborations, addressing the challenging detector requirements with innovative technologies. This report introduces the experimental environment and detector requirements at CLIC and reviews the current status and future plans for detector technology R&D., Comment: 152 pages, 116 figures; published as CERN Yellow Report Monograph Vol. 1/2019; corresponding editors: Dominik Dannheim, Katja Kr\"uger, Aharon Levy, Andreas N\"urnberg, Eva Sicking
- Published
- 2019
- Full Text
- View/download PDF
10. FairLex: A Multilingual Benchmark for Evaluating Fairness in Legal Text Processing.
- Author
-
Ilias Chalkidis, Tommaso Pasini, Sheng Zhang 0022, Letizia Tomada, Sebastian Felix Schwemer, and Anders Søgaard
- Published
- 2022
- Full Text
- View/download PDF
11. Underexplored Microbial Species in the Pipeline for the Development of Biopesticides
- Author
-
Tomada, Selena, primary
- Published
- 2022
- Full Text
- View/download PDF
12. Characterization of phenolic profile in dried grape skin of Vitis vinifera L. cv. Pinot Blanc with UHPLC-MS/MS and its development during ripening
- Author
-
Serni, E., Tomada, S., Haas, F., and Robatscher, P.
- Published
- 2022
- Full Text
- View/download PDF
13. Consensos em HPV Masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: Seguimento
- Author
-
Palmas, Artur, Jorge Pereira, Bruno, Graça, Bruno, Eufrásio, Pedro, Silva, Alberto, Santos, Sérgio, Cardoso, Pepe, Tomada, Nuno, and Vendeira, Pedro
- Published
- 2022
- Full Text
- View/download PDF
14. Thermal detection of single e-h pairs in a biased silicon crystal detector
- Author
-
Romani, R. K., Brink, P. L., Cabrera, B., Cherry, M., Howarth, T., Kurinsky, N., Moffatt, R. A., Partridge, R., Ponce, F., Pyle, M., Tomada, A., Yellin, S., Yen, J. J., and Young, B. A.
- Subjects
Physics - Instrumentation and Detectors - Abstract
We demonstrate that individual electron-hole pairs are resolved in a 1 cm$^2$ by 4 mm thick silicon crystal (0.93 g) operated at $\sim$35 mK. One side of the detector is patterned with two quasiparticle-trap-assisted electro-thermal-feedback transition edge sensor (QET) arrays held near ground potential. The other side contains a bias grid with 20\% coverage. Bias potentials up to $\pm$ 160 V were used in the work reported here. A fiber optic provides 650~nm (1.9 eV) photons that each produce an electron-hole ($e^{-} h^{+}$) pair in the crystal near the grid. The energy of the drifting charges is measured with a phonon sensor noise $\sigma$ $\sim$0.09 $e^{-} h^{+}$ pair. The observed charge quantization is nearly identical for $h^+$'s or $e^-$'s transported across the crystal., Comment: 4 journal pages, 5 figures
- Published
- 2017
- Full Text
- View/download PDF
15. Inflatable penile prosthesis reservoir placement—Are we ready for a paradigm change?
- Author
-
Tomada, Nuno and Egydio, Paulo
- Published
- 2022
- Full Text
- View/download PDF
16. Legal AI Systems in the EU's proposed Artificial Intelligence Act.
- Author
-
Sebastian Felix Schwemer, Letizia Tomada, and Tommaso Pasini
- Published
- 2021
17. Detector Damage at X-Ray Free-Electron Laser Sources
- Author
-
Blaj, G., Carini, G., Carron, S., Haller, G., Hart, P., Hasi, J., Herrmann, S., Kenney, C., Segal, J., Stan, C. A., and Tomada, A.
- Subjects
Physics - Instrumentation and Detectors - Abstract
Free-electron lasers (FELs) opened a new window on imaging the motion of atoms and molecules. At SLAC, FEL experiments are performed at LCLS using 120 Hz pulses with 10^12 to 10^13 photons in 10 fs (billions of times brighter than at the most powerful synchrotrons). Concurrently, users and staff operate under high pressure due to flexible and often rapidly changing setups and low tolerance for system malfunction. This extreme detection environment raises unique challenges, from obvious to surprising, and leads to treating detectors as consumables. We discuss in detail the detector damage mechanisms observed in 7 years of operation at LCLS, together with the corresponding damage mitigation strategies and their effectiveness. Main types of damage mechanisms already identified include: (1) x-ray radiation damage (from "catastrophic" to "classical"), (2) direct and indirect damage caused by optical lasers, (3) sample induced damage, (4) vacuum related damage, (5) high-pressure environment. In total, 19 damage mechanisms have been identified. We also present general strategies for reducing damage risk or minimizing the impact of detector damage on the science program. These include availability of replacement parts and skilled operators and also careful planning, incident investigation resulting in updated designs, procedures and operator training., Comment: 10 pages, 6 figures, 2 tables
- Published
- 2017
- Full Text
- View/download PDF
18. Optimal pulse processing, pile-up decomposition and applications of silicon drift detectors at LCLS
- Author
-
Blaj, G., Kenney, C. J., Dragone, A., Carini, G., Herrmann, S., Hart, P., Tomada, A., Koglin, J., Haller, G., Boutet, S., Messerschmidt, M., Williams, G., Chollet, M., Dakovski, G., Nelson, S., Pines, J., Song, S., and Thayer, J.
- Subjects
Physics - Instrumentation and Detectors ,Physics - Data Analysis, Statistics and Probability - Abstract
Silicon drift detectors (SDDs) revolutionized spectroscopy in fields as diverse as geology and dentistry. For a subset of experiments at ultra-fast, x-ray free-electron lasers (FELs), SDDs can make substantial contributions. Often the unknown spectrum is interesting, carrying science data, or the background measurement is useful to identify unexpected signals. Many measurements involve only several discrete photon energies known a priori, allowing single event decomposition of pile-up and spectroscopic photon counting. We designed a pulse function and demonstrated that the signal amplitude and rise time are obtained for each pulse by fitting, thus removing the need for pulse shaping. By avoiding pulse shaping, rise times of tens of nanoseconds resulted in reduced pulse pile-up and allowed decomposition of remaining pulse pile-up at photon separation times down to hundreds of nanoseconds while yielding time-of-arrival information with precision of 10 nanoseconds. Waveform fitting yields simultaneously high energy resolution and high counting rates (2 orders of magnitude higher than current digital pulse processors). We showed that pile-up spectrum fitting is relatively simple and preferable to pile-up spectrum deconvolution. We developed a photon pile-up statistical model for constant intensity sources, extended it to variable intensity sources (typical for FELs) and used it to fit a complex pile-up spectrum. We subsequently developed a Bayesian pile-up decomposition method that allows decomposing pile-up of single events with up to 6 photons from 6 monochromatic lines with 99% accuracy. The usefulness of SDDs will continue into the x-ray FEL era of science. Their successors, the ePixS hybrid pixel detectors, already offer hundreds of pixels, each with similar performance to an SDD, in a compact, robust and affordable package, Comment: 16 pages, 11 figures, 4 tables
- Published
- 2017
- Full Text
- View/download PDF
19. Demonstrating a Long-Coherence Dual-Rail Erasure Qubit Using Tunable Transmons
- Author
-
Levine, H., primary, Haim, A., additional, Hung, J. S. C., additional, Alidoust, N., additional, Kalaee, M., additional, DeLorenzo, L., additional, Wollack, E. A., additional, Arrangoiz-Arriola, P., additional, Khalajhedayati, A., additional, Sanil, R., additional, Moradinejad, H., additional, Vaknin, Y., additional, Kubica, A., additional, Hover, D., additional, Aghaeimeibodi, S., additional, Alcid, J. A., additional, Baek, C., additional, Barnett, J., additional, Bawdekar, K., additional, Bienias, P., additional, Carson, H. A., additional, Chen, C., additional, Chen, L., additional, Chinkezian, H., additional, Chisholm, E. M., additional, Clifford, A., additional, Cosmic, R., additional, Crisosto, N., additional, Dalzell, A. M., additional, Davis, E., additional, D’Ewart, J. M., additional, Diez, S., additional, D’Souza, N., additional, Dumitrescu, P. T., additional, Elkhouly, E., additional, Fang, M. T., additional, Fang, Y., additional, Flammia, S., additional, Fling, M. J., additional, Garcia, G., additional, Gharzai, M. K., additional, Gorshkov, A. V., additional, Gray, M. J., additional, Grimberg, S., additional, Grimsmo, A. L., additional, Hann, C. T., additional, He, Y., additional, Heidel, S., additional, Howell, S., additional, Hunt, M., additional, Iverson, J., additional, Jarrige, I., additional, Jiang, L., additional, Jones, W. M., additional, Karabalin, R., additional, Karalekas, P. J., additional, Keller, A. J., additional, Lasi, D., additional, Lee, M., additional, Ly, V., additional, MacCabe, G., additional, Mahuli, N., additional, Marcaud, G., additional, Matheny, M. H., additional, McArdle, S., additional, McCabe, G., additional, Merton, G., additional, Miles, C., additional, Milsted, A., additional, Mishra, A., additional, Moncelsi, L., additional, Naghiloo, M., additional, Noh, K., additional, Oblepias, E., additional, Ortuno, G., additional, Owens, J. C., additional, Pagdilao, J., additional, Panduro, A., additional, Paquette, J.-P., additional, Patel, R. N., additional, Peairs, G., additional, Perello, D. J., additional, Peterson, E. C., additional, Ponte, S., additional, Putterman, H., additional, Refael, G., additional, Reinhold, P., additional, Resnick, R., additional, Reyna, O. A., additional, Rodriguez, R., additional, Rose, J., additional, Rubin, A. H., additional, Runyan, M., additional, Ryan, C. A., additional, Sahmoud, A., additional, Scaffidi, T., additional, Shah, B., additional, Siavoshi, S., additional, Sivarajah, P., additional, Skogland, T., additional, Su, C.-J., additional, Swenson, L. J., additional, Sylvia, J., additional, Teo, S. M., additional, Tomada, A., additional, Torlai, G., additional, Wistrom, M., additional, Zhang, K., additional, Zuk, I., additional, Clerk, A. A., additional, Brandão, F. G. S. L., additional, Retzker, A., additional, and Painter, O., additional
- Published
- 2024
- Full Text
- View/download PDF
20. The role and needs of family doctors in sexual medicine: contributions of a preliminary Portuguese qualitative study for a global action
- Author
-
Rodrigues, Margarida G., primary, Manão, Andreia A., additional, Tomada, Nuno, additional, and Pascoal, Patrícia M., additional
- Published
- 2024
- Full Text
- View/download PDF
21. Molecular genetic variability of Cryphonectria hypovirus 1 associated with Cryphonectria parasitica in South Tyrol (northern Italy)
- Author
-
Ahmad, Farooq, primary, Tomada, Selena, additional, Poonsiri, Thanalai, additional, and Baric, Sanja, additional
- Published
- 2024
- Full Text
- View/download PDF
22. Surgical Treatment of Erectile Dysfunction: Historical Perspective and Overview
- Author
-
Morgado, Afonso, Tomada, Nuno, Sarquella, Joaquim, Martins, Francisco E., editor, Kulkarni, Sanjay B., editor, and Köhler, Tobias S., editor
- Published
- 2020
- Full Text
- View/download PDF
23. Consensos em HPV Masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: Tratamento
- Author
-
Jorge Pereira, Bruno, Graça, Bruno, Palmas, Artur, Eufrásio, Pedro, Lebre, Ana, Andrade, Pedro, Louro, Nuno, Azinhais, Paulo, Cardoso, Pepe, Tomada, Nuno, and Vendeira, Pedro
- Published
- 2021
- Full Text
- View/download PDF
24. Recomendações em HPV Masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: Prevenção
- Author
-
Eufrásio, Pedro, Jorge Pereira, Bruno, Graça, Bruno, Palmas, Artur, Santiago, Felicidade, Borges, Ricardo, Bollini, Sílvio, Rebelo, Teresa, Cardoso, Pepe, Tomada, Nuno, and Vendeira, Pedro
- Published
- 2021
- Full Text
- View/download PDF
25. Consensos em HPV masculino da Sociedade Portuguesa de Andrologia, Medicina Sexual e Reprodução: diagnóstico
- Author
-
Graça, Bruno, Jorge Pereira, Bruno, Palmas, Artur, Eufrásio, Pedro, Serrão, Vasco, Lourenço Reis, José, Pinheiro Lopes, Sofia, Ilgenfritz, Raquel, Cardoso, Pepe, Tomada, Nuno, and Vendeira, Pedro
- Published
- 2021
- Full Text
- View/download PDF
26. Imaging the Oblique Propagation of Electrons in Germanium Crystals at Low Temperature and Low Electric Field
- Author
-
Moffatt, R. A., Cabrera, B., Corcoran, B. M., Kreikebaum, J. M., Redl, P., Shank, B., Yen, J. J., Young, B. A., Brink, P. L., Cherry, M., Tomada, A., Phipps, A., Sadoulet, B., and Sundqvist, K. M.
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Excited electrons in the conduction band of germanium collect into four energy minima, or valleys, in momentum space. These local minima have highly anisotropic mass tensors which cause the electrons to travel in directions which are oblique to an applied electric field at sub-Kelvin temperatures and low electric fields, in contrast to the more isotropic behavior of the holes. This experiment produces, for the first time, a full two-dimensional image of the oblique electron and hole propagation and the quantum transitions of electrons between valleys for electric fields oriented along the [0,0,1] direction. Charge carriers are excited with a focused laser pulse on one face of a germanium crystal and then drifted through the crystal by a uniform electric field of strength between 0.5 and 6 V/cm. The pattern of charge density arriving on the opposite face is used to reconstruct the trajectories of the carriers. Measurements of the two-dimensional pattern of charge density are compared in detail with Monte Carlo simulations developed for the Cryogenic Dark Matter Search (CDMS) to model the transport of charge carriers in high-purity germanium detectors.
- Published
- 2015
- Full Text
- View/download PDF
27. Growth of alpha-beta phase W thin films over steep Al topography in a confocal sputtering machine
- Author
-
Kreikebaum, John Mark, Cabrera, Blas, Yen, Jeff, Brink, Paul, Tomada, Astrid, Cherry, Matt, and Young, Betty
- Subjects
Condensed Matter - Materials Science - Abstract
We report on thin-film processing improvements in the fabrication of superconducting quasiparticle-trap-assisted electrothermal-feedback transition-edge sensors (QETs) used in the design of Cryogenic Dark Matter Search (CDMS) detectors. The work was performed as part of a detector upgrade project that included optimization of a new confocal sputtering system and development of etch recipes compatible with patterning 40 nm-thick, mixed-phase W films deposited on 300-600 nm-thick, patterned Al. We found that our standard exothermic Al wet etch recipes provided inadequate W/Al interfaces and led to poor device performance. We developed a modified Al wet-etch recipe that effectively mitigates geometrical step-coverage limitations while maintaining our existing device design. Data presented here include SEM and FIB images of films and device interfaces obtained with the new Al etch method. We also introduce a method for quantitatively measuring the energy collection efficiency through these interfaces., Comment: 9 pages; 7 figures
- Published
- 2014
28. Hepatectomy versus Chemotherapy for Resectable Colorectal Liver Metastases in Progression after Perioperative Chemotherapy: Expanding the Boundaries of the Curative Intent
- Author
-
Simone Famularo, Flavio Milana, Matteo Cimino, Fabio Procopio, Guido Costa, Jacopo Galvanin, Elisa Paoluzzi Tomada, Francesca Margherita Bunino, Angela Palmisano, Matteo Donadon, and Guido Torzilli
- Subjects
colorectal liver metastases ,liver resection ,disease progression ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Disease progression (PD) at neoadjuvant chemotherapy for patients with colorectal liver metastases (CLMs) is considered a contraindication to hepatic resection. Our aim was to estimate the overall survival (OS) in patients undergoing surgery compared with those treated exclusively with chemotherapy in cases of PD. Patients from a single centre with PD were analyzed and subdivided into two groups: hepatectomy (HEP) versus chemotherapy (CHT). An Inverse Probability Weighting (IPW) was run to balance the baseline differences between the two groups. A Cox regression was carried out on identifying factors predicting mortality. From 2010 to 2020, 105 patients in PD to at least one line of chemotherapy were analyzed. Of these, 27 (25.7%) underwent hepatic resection. After a median follow-up of 30 (IQR 14–46) months, 61.9% were dead. The OS values at 1 and 3 years were 54.4 and 10.6% for CHT, and 95 and 46.8% for HEP (p < 0.001). After IPW, two balanced pseudopopulations were obtained: HEP = 85 and CHT = 103. The OS values at 1 and 3 years were 54.4 and 10.6% for CHT, and 97.8 and 49.3% for HEP (HR 0.256, 95%CI: 0.08–0.78, p = 0.033). After IPW, in the multivariate model, surgery resulted in the only protective variable (HR 0.198, 95%CI: 0.08–0.48, p = 0.0016). Our results show that hepatic resection could offer a chance of a longer OS than the prosecution of chemotherapy only in originally resectable patients.
- Published
- 2023
- Full Text
- View/download PDF
29. Controversies in IPAA for Ulcerative Colitis: A Systematic Review of Different Anastomotic Techniques.
- Author
-
Gustavo Kotze, Paulo, Avellaneda, Nicolas, Molteni Moretti, Rafaela de Araujo, Carvello, Michele, Paoluzzi Tomada, Elisa, Guilherme Campos, Fabio, and Spinelli, Antonino
- Published
- 2024
- Full Text
- View/download PDF
30. Generating carbon nanotube caps of almost all chiralities, using six molecular segment types.
- Author
-
Konstantin Amsharov, Andreas Knauf, and Jörg Tomada
- Published
- 2020
- Full Text
- View/download PDF
31. Non-destructive fluorescence sensing for assessing microclimate, site and defoliation effects on flavonol dynamics and sugar prediction in Pinot blanc grapes.
- Author
-
Selena Tomada, Giovanni Agati, Enrico Serni, Samanta Michelini, Valentina Lazazzara, Ulrich Pedri, Christof Sanoll, Aldo Matteazzi, Peter Robatscher, and Florian Haas
- Subjects
Medicine ,Science - Abstract
In an era of growing international competition in modern viticulture, the study and implementation of innovative technologies to increase the production of high-quality grapes and wines are of critical importance. In this study, the non-destructive portable sensor Multiplex, based on fluorescence sensing technique, was applied to evaluate grape maturity parameters and flavonol content of the understudied Pinot blanc variety. The effects of environmental and agronomical factors on flavonol content of Pinot blanc grapes were investigated in eight vineyards characterised by different microclimatic and agronomic conditions. Furthermore, the direct impact of canopy management treatment on the flavonol dynamics of the grapes oriented in the four cardinal directions was assessed. Results highlight the positive role of moderate temperatures and direct sunlight exposure on Pinot blanc flavonol content; however, no direct vineyard-elevation effect was observed. The ability to modulate and evaluate the flavonol content in field represent crucial factors because of their potential effect on flavonoids-dependent wine characteristics, such as stability and ageing. In the present study, for the first time, two calibration curves were reported for pre- and post-veraison periods between flavonol indices and the berry skin flavonol content and a good correlation was observed between Multiplex measurement and the total polyphenolic content of grape juice. Moreover, the strong correlation between the chlorophyll index with grape juice sugar content and titratable acidity revealed the practical application of non-destructive sensors to predict the optimal harvest time for Pinot blanc grapes. In conclusion, the non-destructive fluorescence sensor Multiplex is a high-potential tool for innovative viticulture, for evaluating grape skin composition variables in white grape varieties.
- Published
- 2022
- Full Text
- View/download PDF
32. Measurement Of Quasiparticle Transport In Aluminum Films Using Tungsten Transition-Edge Sensors
- Author
-
Yen, J. J., Shank, B., Young, B. A., Cabrera, B., Brink, P. L., Cherry, M., Kreikebaum, J. M, Moffatt, R., Redl, P., Tomada, A., and Tortorici, E. C.
- Subjects
Physics - Instrumentation and Detectors - Abstract
We report new experimental studies to understand the physics of phonon sensors which utilize quasiparticle diffusion in thin aluminum films into tungsten transition-edge-sensors (TESs) operated at 35 mK. We show that basic TES physics and a simple physical model of the overlap region between the W and Al films in our devices enables us to accurately reproduce the experimentally observed pulse shapes from x-rays absorbed in the Al films. We further estimate quasiparticle loss in Al films using a simple diffusion equation approach., Comment: 5 pages, 6 figures, PRAL
- Published
- 2014
- Full Text
- View/download PDF
33. Nonlinear Optimal Filter Technique For Analyzing Energy Depositions In TES Sensors Driven Into Saturation
- Author
-
Shank, B., Yen, J. J., Cabrera, B., Kreikebaum, J. M., Moffatt, R., Redl, P., Young, B. A., Brink, P. L., Cherry, M., and Tomada, A.
- Subjects
Physics - Instrumentation and Detectors ,Condensed Matter - Superconductivity - Abstract
We present a detailed thermal and electrical model of superconducting transition edge sensors (TESs) connected to quasiparticle (qp) traps, such as the W TESs connected to Al qp traps used for CDMS (Cryogenic Dark Matter Search) Ge and Si detectors. We show that this improved model, together with a straightforward time-domain optimal filter, can be used to analyze pulses well into the nonlinear saturation region and reconstruct absorbed energies with optimal energy resolution., Comment: companion paper to J. J. Yen's "Measurement Of Quasiparticle Transport In Aluminum Films Using Tungsten Transition-Edge Sensors"
- Published
- 2014
34. Search for Low-Mass WIMPs with SuperCDMS
- Author
-
Agnese, R., Anderson, A. J., Asai, M., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Beaty, J., Billard, J., Borgland, A., Bowles, M. A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Chen, Y., Cherry, M., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., DeVaney, D., Di Stefano, P. C. F., Silva, E. Do Couto E, Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Godfrey, G. L., Golwala, S. R., Hall, J., Hansen, S., Harris, H. R., Hertel, S. A., Hines, B. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kenany, S., Kennedy, A., Kiveni, M., Koch, K., Leder, A., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Nelson, R. H., Novak, L., Page, K., Partridge, R., Pepin, M., Phipps, A., Platt, M., Prasad, K., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Resch, R. W., Ricci, Y., Ruschman, M., Saab, T., Sadoulet, B., Sander, J., Schmitt, R. L., Schneck, K., Schnee, R. W., Scorza, S., Seitz, D. N., Serfass, B., Shank, B., Speller, D., Tomada, A., Upadhyayula, S., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.
- Subjects
High Energy Physics - Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Physics - Instrumentation and Detectors - Abstract
We report a first search for weakly interacting massive particles (WIMPs) using the background rejection capabilities of SuperCDMS. An exposure of 577 kg-days was analyzed for WIMPs with mass < 30 GeV/c2, with the signal region blinded. Eleven events were observed after unblinding. We set an upper limit on the spin-independent WIMP-nucleon cross section of 1.2e-42 cm2 at 8 GeV/c2. This result is in tension with WIMP interpretations of recent experiments and probes new parameter space for WIMP-nucleon scattering for WIMP masses < 6 GeV/c2., Comment: 6 pages, 4 figures; figure 1 updated, submitted to Phys. Rev. Lett
- Published
- 2014
- Full Text
- View/download PDF
35. Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types
- Author
-
Magnuson, Angela M., Kiner, Evgeny, Ergun, Ayla, Park, Jun Seok, Asinovski, Natasha, Ortiz-Lopez, Adriana, Kilcoyne, Aoife, Paoluzzi-Tomada, Elisa, Weissleder, Ralph, Mathis, Diane, and Benoist, Christophe
- Published
- 2018
36. IRF4 instructs effector Treg differentiation and immune suppression in human cancer
- Author
-
Alvisi, Giorgia, Brummelman, Jolanda, Puccio, Simone, Mazza, Emilia M.C., Tomada, Elisa Paoluzzi, Losurdo, Agnese, Zanon, Veronica, Peano, Clelia, Colombo, Federico S., Scarpa, Alice, Alloisio, Marco, Vasanthakumar, Ajithkumar, Roychoudhuri, Rahul, Kallikourdis, Marinos, Pagani, Massimiliano, Lopci, Egesta, Novellis, Pierluigi, Blume, Jonas, Kallies, Axel, Veronesi, Giulia, and Lugli, Enrico
- Subjects
Cancer ,Chemotherapy ,Non-small cell lung cancer ,T cells ,Health care industry - Abstract
The molecular mechanisms responsible for the high immunosuppressive capacity of [CD4.sup.+] Tregs in tumors are not well known. High-dimensional single-cell profiling of T cells from chemotherapy-naive individuals with non-small-cell lung cancer identified the transcription factor IRF4 as specifically expressed by a subset of intratumoral [CD4.sup.+] effector Tregs with superior suppressive activity. In contrast to the [IRF4.sup.-] counterparts, [IRF4.sup.+] Tregs expressed a vast array of suppressive molecules, and their presence correlated with multiple exhausted subpopulations of T cells. Integration of transcriptomic and epigenomic data revealed that IRF4, either alone or in combination with its partner BATF, directly controlled a molecular program responsible for immunosuppression in tumors. Accordingly, deletion of Irf4 exclusively in Tregs resulted in delayed tumor growth in mice while the abundance of IRF4+ Tregs correlated with poor prognosis in patients with multiple human cancers. Thus, a common mechanism underlies immunosuppression in the tumor microenvironment irrespective of the tumor type., Introduction Despite recent clinical breakthroughs in adoptive T cell transfer approaches and checkpoint blockade in treating hematopoietic and solid tumors, suppression of the antitumor immune response in the tumor microenvironment [...]
- Published
- 2020
- Full Text
- View/download PDF
37. Demonstration of Surface Electron Rejection with Interleaved Germanium Detectors for Dark Matter Searches
- Author
-
Agnese, R., Anderson, A. J., Balakishiyeva, D., Thakur, R. Basu, Bauer, D. A., Borgland, A., Brandt, D., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cerdeno, D. G., Chagani, H., Cherry, M., Cooley, J., Cornell, B., Crewdson, C. H., Cushman, P., Daal, M., Di Stefano, P. C. F., Silva, E. Do Couto E, Doughty, T., Esteban, L., Fallows, S., Figueroa-Feliciano, E., Fox, J., Fritts, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Hasi, J., Hertel, S. A., Hines, B. A., Hofer, T., Holmgren, D., Hsu, L., Huber, M. E., Jastram, A., Kamaev, O., Kara, B., Kelsey, M. H., Kenany, S. A., Kennedy, A., Kenney, C. J., Kiveni, M., Koch, K., Loer, B., Asamar, E. Lopez, Mahapatra, R., Mandic, V., Martinez, C., McCarthy, K. A., Mirabolfathi, N., Moffatt, R. A., Moore, D. C., Nadeau, P., Nelson, R. H., Novak, L., Page, K., Partridge, R., Pepin, M., Phipps, A., Prasad, K., Pyle, M., Qiu, H., Radpour, R., Rau, W., Redl, P., Reisetter, A., Resch, R. W., Ricci, Y., Saab, T., Sadoulet, B., Sander, J., Schmitt, R., Schneck, K., Schnee, R. W., Scorza, S., Seitz, D., Serfass, B., Shank, B., Speller, D., Tomada, A., Villano, A. N., Welliver, B., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., and Zhang, J.
- Subjects
Physics - Instrumentation and Detectors ,Astrophysics - Astrophysics of Galaxies ,High Energy Physics - Experiment - Abstract
The SuperCDMS experiment in the Soudan Underground Laboratory searches for dark matter with a 9-kg array of cryogenic germanium detectors. Symmetric sensors on opposite sides measure both charge and phonons from each particle interaction, providing excellent discrimination between electron and nuclear recoils, and between surface and interior events. Surface event rejection capabilities were tested with two $^{210}$Pb sources producing $\sim$130 beta decays/hr. In $\sim$800 live hours, no events leaked into the 8--115 keV signal region, giving upper limit leakage fraction $1.7 \times 10^{-5}$ at 90% C.L., corresponding to $< 0.6$ surface event background in the future 200-kg SuperCDMS SNOLAB experiment., Comment: 5 pages, 4 figures, submitted to journal
- Published
- 2013
- Full Text
- View/download PDF
38. Optimization of the method for analyzing endocytosis of fluorescently tagged molecules: Impact of incubation in the cell culture medium and cell surface wash with glycine-hydrochloric acid buffer
- Author
-
Kamei, Noriyasu, Yamamoto, Satoshi, Hashimoto, Hiro, Nishii, Megumi, Miyaura, Moe, Tomada, Kiho, Nakase, Ikuhiko, and Takeda-Morishita, Mariko
- Published
- 2019
- Full Text
- View/download PDF
39. Monte Carlo Comparisons to a Cryogenic Dark Matter Search Detector with low Transition-Edge-Sensor Transition Temperature
- Author
-
Leman, S. W., McCarthy, K. A., Brink, P. L., Cabrera, B., Cherry, M., Silva, E. Do Couto E, Figueroa-Feliciano, E., Kim, P., Mirabolfathi, N., Pyle, M., Resch, R., Sadoulet, B., Serfass, B., Sundqvist, K. M., Tomada, A., and Young, B. A.
- Subjects
Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics ,Condensed Matter - Materials Science - Abstract
We present results on phonon quasidiffusion and Transition Edge Sensor (TES) studies in a large, 3 inch diameter, 1 inch thick [100] high purity germanium crystal, cooled to 50 mK in the vacuum of a dilution refrigerator, and exposed with 59.5 keV gamma-rays from an Am-241 calibration source. We compare calibration data with results from a Monte Carlo which includes phonon quasidiffusion and the generation of phonons created by charge carriers as they are drifted across the detector by ionization readout channels. The phonon energy is then parsed into TES based phonon readout channels and input into a TES simulator.
- Published
- 2011
- Full Text
- View/download PDF
40. Validation of Phonon Physics in the CDMS Detector Monte Carlo
- Author
-
McCarthy, K. A., Leman, S. W., Anderson, A. J., Brandt, D., Brink, P. L., Cabrera, B., Cherry, M., Silva, E. Do Couto E, Cushman, P., Doughty, T., Figueroa-Feliciano, E., Kim, P., Mirabolfathi, N., Novak, L., Partridge, R., Pyle, M., Reisetter, A., Resch, R., Sadoulet, B., Serfass, B., Sundqvist, K. M., and Tomada, A.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The SuperCDMS collaboration is a dark matter search effort aimed at detecting the scattering of WIMP dark matter from nuclei in cryogenic germanium targets. The CDMS Detector Monte Carlo (CDMS-DMC) is a simulation tool aimed at achieving a deeper understanding of the performance of the SuperCDMS detectors and aiding the dark matter search analysis. We present results from validation of the phonon physics described in the CDMS-DMC and outline work towards utilizing it in future WIMP search analyses., Comment: 6 Pages, 5 Figures, Proceedings of Low Temperature Detectors 14 Conference
- Published
- 2011
- Full Text
- View/download PDF
41. Time Evolution of Electric Fields in CDMS Detectors
- Author
-
Leman, S. W., Brandt, D., Brink, P. L., Cabrera, B., Chagani, H., Cherry, M., Cushman, P., Silva, E. Do Couto E, Doughty, T., Figueroa-Feliciano, E., Mandic, V., McCarthy, K. A., Mirabolfathi, N., Pyle, M., Reisetter, A., Resch, R., Sadoulet, B., Serfass, B., Sundqvist, K. M., Tomada, A., Young, B. A., and Zhang, J.
- Subjects
Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics ,Condensed Matter - Materials Science ,High Energy Physics - Experiment - Abstract
The Cryogenic Dark Matter Search (CDMS) utilizes large mass, 3" diameter x 1" thick target masses as particle detectors. The target is instrumented with both phonon and ionization sensors, the later providing a $\sim$1 V cm$^{-1}$ electric field in the detector bulk. Cumulative radiation exposure which creates $\sim 200\times 10^6$ electron-hole pairs is sufficient to produce a comparable reverse field in the detector thereby degrading the ionization channel performance. To study this, the existing CDMS detector Monte Carlo has been modified to allow for an event by event evolution of the bulk electric field, in three spatial dimensions. Our most resent results and interpretation are discussed., Comment: Low Temperature Detectors 14 conference proceeding to be published in the Journal of Low Temperature Physics
- Published
- 2011
- Full Text
- View/download PDF
42. Phonon Quasidiffusion in Cryogenic Dark Matter Search Large Germanium Detectors
- Author
-
Leman, S. W., Cabrera, B., McCarthy, K. A., Pyle, M., Resch, R., Sadoulet, B., Sundqvist, K. M., Brink, P. L., Cherry, M., Silva, E. Do Couto E, Figueroa-Feliciano, E., Mirabolfathi, N., Serfass, B., and Tomada, A.
- Subjects
Physics - Instrumentation and Detectors ,Condensed Matter - Materials Science ,High Energy Physics - Experiment - Abstract
We present results on quasidiffusion studies in large, 3 inch diameter, 1 inch thick [100] high purity germanium crystals, cooled to 50 mK in the vacuum of a dilution refrigerator, and exposed with 59.5 keV gamma-rays from an Am-241 calibration source. We compare data obtained in two different detector types, with different phonon sensor area coverage, with results from a Monte Carlo. The Monte Carlo includes phonon quasidiffusion and the generation of phonons created by charge carriers as they are drifted across the detector by ionization readout channels., Comment: 13 pages, 12 figures, PHONONS201 conference proceedings; http://psroc.phys.ntu.edu.tw/cjp/download.php?d=4&pid=2718
- Published
- 2011
43. Modeling malic acid dynamics to ensure quality, aroma and freshness of Pinot blanc wines in South Tyrol (Italy)
- Author
-
Samnata Michelini, Selena Tomada, Amy Ellen Kadison, Florian Pichler, Fenja Hinz, Martin Zejfart, Francesco Iannone, Valentina Lazazzara, Christof Sanoll, Peter Robatscher, Ulrich Pedri, and Florian Haas
- Subjects
South Tyrol ,sugar ,GDD ,GSR ,organic acid ,MA ,Agriculture ,Botany ,QK1-989 - Abstract
Pinot blanc is a leading grapevine variety in South Tyrol (Italy) for wine production. The high quality of its wines derives from a typical aroma of elegant apple notes and lively acidity. The typicity of the final wine depends on the origin of the vine, the soil, the oenological practices and time of harvest. The South Tyrolean mountainous areas meet the cold climatic requirements of Pinot blanc, which guarantee its sweet-acidic harmony obtained when organic acids are in balance with the other components of the wine. However, increasing temperatures in valley sites during the berry development period boost the activity of malic acid (MA) enzymes, which negatively affect the final sugar/acid ratio. Researchers are currently focused on understanding acid dynamics in wines, and there are no references for the best sugar/acid ratio for Pinot blanc. Moreover, the contribution of individual acids to the sensory profile of this wine has not yet been studied. In this study we address the effect of different climate conditions and site elevations on the sugar/acid ratio in developmental grapevine berries, and we evaluate the effect on wine bouquet. Even if different models and indices have been proposed for predicting sugar content, no predictive models exist for MA in white grapes. In a three-year study (2017, 2018 and 2019) that involved eight vineyards in four different location in South Tyrol at various elevations ranging from 223 to 730 m a.s.l., the relationships between bioclimatic indices, such as growing-degree day (GDD) and grapevine sugar ripeness (GSR) and grapevine berry content were investigated. The analysis reveals that GDD may potentially predict MA dynamics in Pinot blanc; hence, a GDD-based model was used to determine the GDD to reach target MA concentrations (3.5, 3.0, 2.5, 2.0 g/L). This simple model was improved with additional temperature-based parameters by feature selection, and the best three advanced models were selected and evaluated by 5-fold cross-validation. These models could be used to support location and harvest date choice to produce high-quality Pinot blanc wines.
- Published
- 2021
- Full Text
- View/download PDF
44. Comportamento sexual de estudantes de medicina portugueses e seus fatores preditivos
- Author
-
Peixoto, Carla, Botelho, Francisco, Tomada, Inês, and Tomada, Nuno
- Published
- 2016
- Full Text
- View/download PDF
45. Search for Low-Mass Weakly Interacting Massive Particles with SuperCDMS
- Author
-
Agnese, R, Anderson, AJ, Asai, M, Balakishiyeva, D, Thakur, R Basu, Bauer, DA, Beaty, J, Billard, J, Borgland, A, Bowles, MA, Brandt, D, Brink, PL, Bunker, R, Cabrera, B, Caldwell, DO, Cerdeno, DG, Chagani, H, Chen, Y, Cherry, M, Cooley, J, Cornell, B, Crewdson, CH, Cushman, P, Daal, M, DeVaney, D, Di Stefano, PCF, Do Couto E Silva, E, Doughty, T, Esteban, L, Fallows, S, Figueroa-Feliciano, E, Godfrey, GL, Golwala, SR, Hall, J, Hansen, S, Harris, HR, Hertel, SA, Hines, BA, Hofer, T, Holmgren, D, Hsu, L, Huber, ME, Jastram, A, Kamaev, O, Kara, B, Kelsey, MH, Kenany, S, Kennedy, A, Kiveni, M, Koch, K, Leder, A, Loer, B, Asamar, E Lopez, Mahapatra, R, Mandic, V, Martinez, C, McCarthy, KA, Mirabolfathi, N, Moffatt, RA, Nelson, RH, Novak, L, Page, K, Partridge, R, Pepin, M, Phipps, A, Platt, M, Prasad, K, Pyle, M, Qiu, H, Rau, W, Redl, P, Reisetter, A, Resch, RW, Ricci, Y, Ruschman, M, Saab, T, Sadoulet, B, Sander, J, Schmitt, RL, Schneck, K, Schnee, RW, Scorza, S, Seitz, DN, Serfass, B, Shank, B, Speller, D, Tomada, A, Upadhyayula, S, Villano, AN, Welliver, B, Wright, DH, Yellin, S, Yen, JJ, Young, BA, and Zhang, J
- Subjects
(SuperCDMS Collaboration) ,hep-ex ,astro-ph.CO ,physics.ins-det ,Mathematical Sciences ,Physical Sciences ,Engineering ,General Physics - Abstract
We report a first search for weakly interacting massive particles (WIMPs) using the background rejection capabilities of SuperCDMS. An exposure of 577 kg days was analyzed for WIMPs with mass
- Published
- 2014
46. Combinatorial design of molecular seeds for chirality-controlled synthesis of single-walled carbon nanotubes
- Author
-
Joerg Tomada, Thomas Dienel, Frank Hampel, Roman Fasel, and Konstantin Amsharov
- Subjects
Science - Abstract
Bottom-up synthesis from rationally designed precursor molecules is one of the most promising routes to single-walled carbon nanotubes of any desired chirality. Here, the authors present a combinatorial approach to easily assemble a variety of these complex nanotube precursors from simple complementary segments.
- Published
- 2019
- Full Text
- View/download PDF
47. Demonstration of surface electron rejection with interleaved germanium detectors for dark matter searches
- Author
-
Agnese, R, Anderson, AJ, Balakishiyeva, D, Thakur, R Basu, Bauer, DA, Borgland, A, Brandt, D, Brink, PL, Bunker, R, Cabrera, B, Caldwell, DO, Cerdeno, DG, Chagani, H, Cherry, M, Cooley, J, Cornell, B, Crewdson, CH, Cushman, P, Daal, M, Di Stefano, PCF, Do Couto E Silva, E, Doughty, T, Esteban, L, Fallows, S, Figueroa-Feliciano, E, Fox, J, Fritts, M, Godfrey, GL, Golwala, SR, Hall, J, Harris, HR, Hasi, J, Hertel, SA, Hines, BA, Hofer, T, Holmgren, D, Hsu, L, Huber, ME, Jastram, A, Kamaev, O, Kara, B, Kelsey, MH, Kenany, SA, Kennedy, A, Kenney, CJ, Kiveni, M, Koch, K, Loer, B, Asamar, E Lopez, Mahapatra, R, Mandic, V, Martinez, C, McCarthy, KA, Mirabolfathi, N, Moffatt, RA, Moore, DC, Nadeau, P, Nelson, RH, Novak, L, Page, K, Partridge, R, Pepin, M, Phipps, A, Prasad, K, Pyle, M, Qiu, H, Radpour, R, Rau, W, Redl, P, Reisetter, A, Resch, RW, Ricci, Y, Saab, T, Sadoulet, B, Sander, J, Schmitt, R, Schneck, K, Schnee, RW, Scorza, S, Seitz, D, Serfass, B, Shank, B, Speller, D, Tomada, A, Villano, AN, Welliver, B, Wright, DH, Yellin, S, Yen, JJ, Young, BA, and Zhang, J
- Subjects
physics.ins-det ,astro-ph.GA ,hep-ex ,Physical Sciences ,Engineering ,Technology ,Applied Physics - Abstract
The SuperCDMS experiment in the Soudan Underground Laboratory searches for dark matter with a 9-kg array of cryogenic germanium detectors. Symmetric sensors on opposite sides measure both charge and phonons from each particle interaction, providing excellent discrimination between electron and nuclear recoils, and between surface and interior events. Surface event rejection capabilities were tested with two 210Pb sources producing ∼130 beta decays/hr. In ∼800 live hours, no events leaked into the 8-115 keV signal region, giving upper limit leakage fraction 1.7 × 10-5 at 90% C.L., corresponding to < 0.6 surface event background in the future 200-kg SuperCDMS SNOLAB experiment. © 2013 AIP Publishing LLC.
- Published
- 2013
48. Surgical Treatment of Erectile Dysfunction: Historical Perspective and Overview
- Author
-
Morgado, Afonso, primary, Tomada, Nuno, additional, and Sarquella, Joaquim, additional
- Published
- 2019
- Full Text
- View/download PDF
49. Long-term patient-reported satisfaction with different inflatable penile prosthesis: Comparison between AMS 700CX and Coloplast Titan
- Author
-
Morgado, Afonso, Cavadas, Ana Sofía, Pacheco Figueiredo, Luis, and Tomada, Nuno
- Published
- 2018
- Full Text
- View/download PDF
50. Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat.
- Author
-
B. Rocha, A. R. Rodrigues, I. Tomada, M. J. Martins, J. T. Guimarães, A. M. Gouveia, H. Almeida, and D. Neves
- Subjects
Endothelial dysfunction ,Energy restriction ,Exercise ,Atorvastatin ,Sirtuins ,microRNA-155 ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet pattern, exercise and atorvastatin modulate the expression of eNOS, inducible NOS (iNOS), endothelin-1, sirtuins (SIRT) and microRNA-155 in the erectile tissue of high-fat fed aged rats. Methods Sprague-Dawley male rats fed with high-fat diet until they completed 12 months were grouped and subjected to energy restriction (ER), ER and atorvastatin, or, ER, atorvastatin and physical exercise. Controls were fed with standard rodent chow. The blood pressure was measured using the tail-cuff method before sacrifice at 18 months. Glucose, total cholesterol, HDL, triglyceride and CRP were assessed in blood and eNOS, endothelin-1, iNOS and sirtuins were detected by immunofluorescence in the penis sections; eNOS, endothelin-1, iNOS, SIRT2–4 and SIRT6–7 were semi-quantified by western blotting in tissue homogenates. MicroRNA-155 was quantified using RT-PCR in formalin-fixed paraffin embedded sections. To compare the studied variables, two-tail student t test was used. Results Atorvastatin promotes eNOS expression and is more efficient than ER or exercise in the control of hyperlipidemia and inflammation. Among the studied sirtuins, detected for the first time in the erectile tissue of the aged rat, SIRT2 aligns with eNOS expression. Both proteins exhibit over-expression in animals with combined exercise, atorvastatin and ER. Analysis of microRNA-155 expression also suggests its intervention in the regulation of eNOS expression. ER, particularly when combined with atorvastatin, was able to reverse the increase of iNOS and endothelin-1 in high-fat fed rats. Conclusions The present results indicate that the association of ER, atorvastatin and exercise is more efficient than isolated interventions in the prevention of endothelial dysfunction.
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.