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Introduction: Public health disinformation is a significant problem as demonstrated by the recent scientific literature on the COVID-19 pandemic. However, further studies that analyse the presence of the disinformation mitigation strategies in public health initiatives within specific contexts and which contains a multidimensional approach (gender, social and environmental) are required. Evidence shows that disinformation, information overload, misinformation or fake news on health issues are also influenced by these issues. Objective: The inclusion of the health disinformation dimension within national public implemented by the governments of Argentina and Spain before, during and after the COVID-19 pandemic. Additionally, this paper incorporated a gender-based approach and social and environmental determinants in order to identify the limitations of these initiatives and offer certain recommendations. We conducted a descriptive, qualitative and quantitative study, as well as content analysis. We focused on documents from the websites of the national health ministries of Argentina and Spain, and digital repositories of regulations at the national level. Various strategies for systematic searches on government websites were designed and implemented. This included manual searches on Google. The first step involved a general analysis of all documents found by the searches, followed by a qualitative analysis of the documents that were related to health issues. Based on this work, a comprehensive and flexible framework of (pre-established and emerging) dimensions and categories of health disinformation and infodemics was generated. Results. The work was based on a total of 202 documents (both downloadable information and information included in websites); 117 for Argentina and 85 for Spain. Of the total, 60.9% were published during the COVID-19 pandemic. In the second stage of the analysis, 55 texts were selected for Argentina and 47 for Spain. In both countries, the central communications approach used was disinformation and/or infodemics (although definitions such as fake news were also used). They were mainly linked to the COVID-19 pandemic, but other emerging health problems were also detected to a lesser degree. However, disinformation (or a related concept) was prominently present in only 17 documents in Argentina and 3 documents in Spain. In terms of document type, working materials were foremost in Argentina (44.4%) and Spain (37.6%), with little presence of policy, regulatory and evaluation documents (only 5). Gender binary language was predominantly used in these texts. Vulnerable groups and social determinants were poorly included. Environmental determinants were mentioned in conjunction with health disinformation in only one paper on the use of plastics and its impact on human health in Argentina, and in another paper from the Global Summit on Climate and Health in Spain. Conclusions: Based on the document analysis, the inclusion of health disinformation within public actions in both countries before, during and after the COVID-19 pandemic, was detected. However, different limitations were observed: it was clear that the problem was strongly linked to the health emergency and did not extend much beyond that. Health disinformation was secondary and did not play a key role in public policy nor did it have greater institutional importance. Limitations were also detected in terms of gender perspectives, vulnerable groups and social and environmental determinants linked to health disinformation, displaying a reductionist approach. Based on these results, this paper makes certain policy recommendations. [ABSTRACT FROM AUTHOR]

A brief version of the Alcohol Consumption Consequences Evaluation Scale (ACCE) [38] was developed to promptly detect possible risks related to alcohol consumption, such as Binge Drinking (BD), in university students. Using the "snowball" method, a sample of 595 students aged 18 to 20 (65.4% women) from the University of Valencia (Spain) was obtained during the 2019–2020 academic year. Items with the highest values of the discrimination parameter in the original version (ACCE) were selected and the Rasch model was applied. To verify the usefulness of this version, ROC analyses were conducted separately for men and women using the Audit score as the criterion. In the overall sample, the analysis had an area of 0.812 (SE = 0.018). In men, the area was 0.796 (SE = 0.032) and for women, it was 0.823 (SE = 0.021). In addition, a logistic regression analysis was performed, using a cut-off point of 3 based on the ROC analysis, to assess the utility of this version in classifying BD and non-BD. The odds ratio was 3.812 (p = 0.000), correctly classifying 89.2% of the young people and indicating that the probability of engaging in BD is 3.8 times higher for individuals obtaining more than 3 points on this scale. This result confirms the usefulness of this brief version (ACCE10) as a screening tool for early intervention, especially in clinical or university settings, since it allows young people to be situated within a range of severity according to their consumption patterns. Furthermore, it may help stop the progression of the addictive process, create awareness of the need for change, and facilitate access to the most suitable interventions. [ABSTRACT FROM AUTHOR]

The combination of several therapeutic strategies is often seen as a good way to decrease resistance rates, since bacteria can more easily overcome single-drug treatments than multi-drug ones. This strategy is especially attractive when several targets and subpopulations are affected, as it is the case of Klebsiella pneumoniae persister cells, a subpopulation of bacteria able to transiently survive antibiotic exposures. This work aims to evaluate the potential of a repurposed anticancer drug, mitomycin C, combined with the K. pneumoniae lytic phage vB_KpnM-VAC13 in vitro and its safety in an in vivo murine model against two clinical isolates of this pathogen, one of them exhibiting an imipenem-persister phenotype. At the same time, we verified the absence of toxicity of mitomycin C at the concentration using the human chondrocyte cell line T/C28a2. The viability of these human cells was checked using both cytotoxicity assays and flow cytometry. [ABSTRACT FROM AUTHOR]

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