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Although sea turtles have received substantial focus worldwide, research on the immature life stages is still relatively limited. The latter is of particular importance, given that a large proportion of sea turtle populations comprises immature individuals. We set out to identify knowledge gaps and identify the main barriers hindering research in this field. We analyzed the perceptions of sea turtle experts through an online survey which gathered their opinions on the current state of affairs on immature sea turtle research, including species and regions in need of further study, priority research questions, and barriers that have interfered with the advancement of research. Our gap analysis indicates that studies on immature leatherback Dermochelys coriacea and hawksbill Eretmochelys imbricata turtles are lacking, as are studies on all species based in the Indian, South Pacific, and South Atlantic Oceans. Experts also perceived that studies in population ecology, namely on survivorship and demography, and habitat use/behavior, are needed to advance the state of knowledge on immature sea turtles. Our survey findings indicate the need for more inter-disciplinary research, collaborative efforts (e.g. data-sharing, joint field activities), and improved communication among researchers, funding bodies, stakeholders, and decision-makers.

The available information regarding the 2 sea turtle species breeding in the Mediterranean (loggerhead turtle Caretta caretta and green turtle Chelonia mydas) is reviewed, including biometrics and morphology, identification of breeding and foraging areas, ecology and behaviour, abundance and trends, population structure and dynamics, anthropogenic threats and conservation measures. Although a large body of knowledge has been generated, research efforts have been inconsistently allocated across geographic areas, species and topics. Significant gaps still exist, ranging from the most fundamental aspects, such as the distribution of major nesting sites and the total number of clutches laid annually in the region, to more specific topics like age at maturity, survival rates and behavioural ecology, especially for certain areas (e.g. south-eastern Mediterranean). These gaps are particularly marked for the green turtle. The recent positive trends of nest counts at some nesting sites may be the result of the cessation of past exploitation and decades of conservation measures on land, both in the form of national regulations and of continued active protection of clutches. Therefore, the current status should be considered as dependent on such ongoing conservation efforts. Mitigation of incidental catch in fisheries, the main anthropogenic threat at sea, is still in its infancy. From the analysis of the present status a comprehensive list of research and conservation priorities is proposed.

In 2010, an international group of 35 sea turtle researchers refined an initial list of more than 200 research questions into 20 metaquestions that were considered key for management and conservation of sea turtles. These were classified under 5 categories: reproductive biology, biogeography, population ecology, threats and conservation strategies. To obtain a picture of how research is being focused towards these key questions, we undertook a systematic review of the peer-reviewed literature (2014 and 2015) attributing papers to the original 20 questions. In total, we reviewed 605 articles in full and from these 355 (59%) were judged to substantively address the 20 key questions, with others focusing on basic science and monitoring. Progress to answering the 20 questions was not uniform, and there were biases regarding focal turtle species, geographic scope and publication outlet. Whilst it offers some meaningful indications as to effort, quantifying peer-reviewed literature output is obviously not the only, and possibly not the best, metric for understanding progress towards informing key conservation and management goals. Along with the literature review, an international group based on the original project consortium was assigned to critically summarise recent progress towards answering each of the 20 questions. We found that significant research is being expended towards global priorities for management and conservation of sea turtles. Although highly variable, there has been significant progress in all the key questions identified in 2010. Undertaking this critical review has highlighted that it may be timely to undertake one or more new prioritizing exercises. For this to have maximal benefit we make a range of recommendations for its execution. These include a far greater engagement with social sciences, widening the pool of contributors and focussing the questions, perhaps disaggregating ecology and conservation.

Memories are stored as ensembles of engram neurons and their successful recall involves the reactivation of these cellular networks. However, significant gaps remain in connecting these cell ensembles with the process of forgetting. Here, we utilized a mouse model of object memory and investigated the conditions in which a memory could be preserved, retrieved, or forgotten. Direct modulation of engram activity via optogenetic stimulation or inhibition either facilitated or prevented the recall of an object memory. In addition, through behavioral and pharmacological interventions, we successfully prevented or accelerated forgetting of an object memory. Finally, we showed that these results can be explained by a computational model in which engrams that are subjectively less relevant for adaptive behavior are more likely to be forgotten. Together, these findings suggest that forgetting may be an adaptive form of engram plasticity which allows engrams to switch from an accessible state to an inaccessible state.

El Concilio de Nicea afirmó la divinidad plena del Hijo a través del homoousios con el fin de garantizar que Jesucristo es el verdadero salvador y divinizador del ser humano. Este artículo muestra la pertinencia del concepto de la alteridad intratrinitaria de Dios como correlato de la fórmula cristológica, así como el consenso teológico al respecto desde el pasado siglo. Si Cristo pertenece a la realidad divina, significa que Dios no vive en soledad eterna consigo mismo, sino que es pura relación interpersonal. En este sentido, enseñamos el modo en que este concepto fue fraguado por la patrística prenicena y clarificado por los capadocios. De las repercusiones de dicha comprensión de Dios han de hacerse cargo tanto la ontología filosófica como el conjunto de la teología sistemática. Por ello, atenderemos a la proyección económico-salvífica de la alteridad intratrinitaria, considerando particularmente las doctrinas de la creación y la encarnación.

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It is a generally admitted fact that the optical aligning process of faceted heliostats in a Solar Power Tower Plant (SPTP), also called heliostat canting, introduces an assembly time penalization as well as a potential error in heliostat optics conformation [1, 2]. This double penalization influences both the solar field setup time and the optical quality of the SPTP. Aware of this fact, in 2014 the Plataforma Solar de Almeria (PSA) developed and patented a method to self-align facets and thus avoid the critical canting phase of a heliostat [3]. To experimentally demonstrate the feasibility of the self-aligning facet process, a small reflector composed of six facets and 9m2 of reflecting surface was designed and fabricated. The success of that experience has led to the development of a first 18.5m2 prototype of a self-aligned heliostat, which has been installed at the CESA-1 Heliostat Field (PSA) in 2022.

The cAMP-dependent protein kinase (PKA) is one of the most extensively distributed kinases among intracellular signal cascades, with a pivotal role in the regulation of various processes, including the capacitation of sperm cells. Traditional assessments of PKA activity relies on the utilization of [γ-32P] ATP and the Kemptide substrate. This methodology presents several major drawbacks, including high-costs and health risks derived from the manipulation of radioactive isotopes. In this work we introduce an enhanced non-radioactive assay for quantifying PKA activity, termed KiMSA which relies on the use of a fluorescent-labeled Kemptide (Kemptide-FITC). Once the kinase reaction is terminated, the products can be easily resolved through electrophoresis on an agarose gel and quantified by fluorescence densitometry. We show that the KiMSA assay is suitable for purified PKA, and also to address both basal and capacitation induced PKA activity in mouse sperm cells. Furthermore, the assay enables monitoring the inhibition of PKA with inhibitors such as sPKI and H-89 in live cells. Therefore, the experimental and optimal assay conditions are set so that the KiMSA assay can be used to either assess in vitro as well as in vivo PKA activity in sperm cells. Finally, this method allows for measurement of cAMP concentrations, rendering a versatile technique for the study of cAMP/PKA pathways.

The development of nanomaterials with improved functional characteristics is a priority because of their applicability in medicine. Therefore, in this study, chitosan nanofiber membranes were electrospun with polyvinyl alcohol supplemented with carboxymethyl cellulose and pectin. The membrane characterization included identifying the functional groups of each polymer, the surface appearance, and the absorption capacity of aqueous media, simulating the exudates of skin diseases. Membrane weight loss was close to 50 % during the first day, and they preserved their integrity throughout the study. The mechanical characteristics demonstrated that the membranes with adjuvants are flexible and tough. The rigidity of the membranes was between 10.49 MPa and 22.65 MPa, and this rigidity decreased with the addition of chitosan and pectin. With chitosan, the elongation at break (8.25 %) was higher but the elastic modulus (450.78 MPa) was lower than those recorded with the other polymers. The effect against Staphylococcus aureus occurs due to chitosan and only by contact. In particular, an inhibition zone increased with the addition of chitosan (178.21 mm2). However, carboxymethyl cellulose showed the least shrinkage (4.4 %). Therefore, it is possible to produce nanofibers to make chitosan and polyvinyl alcohol membranes with improved functional characteristics by the addition of adjuvant agents as an alternative to other skin healing materials.

La pandemia COVID-19 ha supuesto un gran desafío para los sistemas de salud y su personal en todo el mundo. El objetivo del estudio fue evaluar la depresión en sanitarios paraguayos que están en contacto con pacientes COVID-19, así como síntomas asociados a la misma. Se realizó un estudio descriptivo transversal. Participaron 130 profesionales paraguayos en el área de la salud mediante muestreo intencional. Se empleó la escala HPQ-9 (Patient Health Questionnaire). Se trata de un instrumento compuesto por 9 ítems relacionados con sintomatología depresiva. La puntuación media obtenida por los sanitarios, en la prueba PHQ-9, fue de 6,56, lo que se interpreta como “depresión leve o moderada”. En las variables de tipo somático, se presentó sensación de cansancio (83,1%), especialmente, en los enfermeros/as (p= ,016). El 58,5% manifestó alteraciones en la alimentación y el 56,2% dificultades en el sueño. En relación con trastornos de personalidad, el 47,7% evidenció síntomas depresivos en los últimos días, en especial las mujeres. El 37,7% se sintió fracasado, el 11,5% en algún momento tuvo ideas suicidas, el 58,4% dificultades en la concentración para actividades y el 41,6% vio afectadas sus relacione sociales. El análisis de regresión logística binaria percibió que el 27,6% de los profesionales en medicina y el 26,3% de enfermería había pensado en abandonar la profesión. Se requiere profundizar en este tipo de estudio para diseñar intervenciones eficaces de protección y ayuda.

The Scale of Physical and Verbal Aggressiveness has been an instrument widely used in the scientific literature to measure physical and verbal aggressiveness, both in children and adolescents as well as in parents. The original scale has shown adequate psychometric properties. However, the scale has not been previously validated in Spanish, and no confirmatory analyses have been provided yet in Spanish contexts. The aim of this paper is to validate the Spanish version of the Physical and Verbal Aggressiveness Scale via confirmatory factor analysis, with a sample of 531 secondary school adolescents from the Dominican Republic. Reliability, factorial, convergent, and discriminant validity evidence is presented. The results showed that the scale has adequate one-factor confirmatory solution, with very good reliability, and adequate validity when assessed in a sample of Dominican students. The results contrast the differentiation between verbal and physical aggression, questioning the use of the scale for this purpose.

[This corrects the article DOI: 10.1017/cts.2020.23.].

A primary barrier to translation of clinical research discoveries into care delivery and population health is the lack of sustainable infrastructure bringing researchers, policymakers, practitioners, and communities together to reduce silos in knowledge and action. As National Institutes of Health's (NIH) mechanism to advance translational research, Clinical and Translational Science Award (CTSA) awardees are uniquely positioned to bridge this gap. Delivering on this promise requires sustained collaboration and alignment between research institutions and public health and healthcare programs and services. We describe the collaboration of seven CTSA hubs with city, county, and state healthcare and public health organizations striving to realize this vision together. Partnership representatives convened monthly to identify key components, common and unique themes, and barriers in academic-public collaborations. All partnerships aligned the activities of the CTSA programs with the needs of the city/county/state partners, by sharing resources, responding to real-time policy questions and training needs, promoting best practices, and advancing community-engaged research, and dissemination and implementation science to narrow the knowledge-to-practice gap. Barriers included competing priorities, differing timelines, bureaucratic hurdles, and unstable funding. Academic-public health/health system partnerships represent a unique and underutilized model with potential to enhance community and population health.

Summary: Long-term memories are stored as configurations of neuronal ensembles, termed engrams. Although investigation of engram cell properties and functionality in memory recall has been extensive, less is known about how engram cells are affected by forgetting. We describe a form of interference-based forgetting using an object memory behavioral paradigm. By using activity-dependent cell labeling, we show that although retroactive interference results in decreased engram cell reactivation during recall trials, optogenetic stimulation of the labeled engram cells is sufficient to induce memory retrieval. Forgotten engrams may be reinstated via the presentation of similar or related environmental information. Furthermore, we demonstrate that engram activity is necessary for interference to occur. Taken together, these findings indicate that retroactive interference modules engram expression in a manner that is both reversible and updatable. Inference may constitute a form of adaptive forgetting where, in everyday life, new perceptual and environmental inputs modulate the natural forgetting process.

In this study, the effect of the polymer matrix structure on the rheological and electrical percolation threshold of polymer/carbon black (CB) conductive polymer composites (CPCs) was investigated. Poly(lactic acid) (PLA) and high‐density polyethylene (HDPE) were used as polymer matrices. Through rheological analyses, an increase in complex viscosity was observed with increasing CB concentration, accompanied by a reduction in the Newtonian plateau. Additionally, an increase in the solid‐like behavior was observed, suggesting the formation of a percolated network. The rheological percolation threshold was found to be 5.13% CB mass fraction for the PLA/CB composite and 10.72% for the HDPE/CB composite. Electrical conductivity results were fitted to the sigmoidal Boltzmann model, and its derivative was used to identify the electrical percolation threshold. For PLA/CB, this threshold was reached at 5.39% CB mass fraction, while for HDPE/CB, it occurred at 5.75%. Morphology analysis by scanning electron microscopy and atomic force microscopy indicated that the polymer matrix structure affected the distribution/dispersion of the CB particles within the polymer matrix. Highlights: The effect of polymer matrix structure on polymer/CB CPCs was investigated.The crystallinity of the polymer matrix affected the percolation threshold.PLA/CB showed higher conductivity than HDPE/CB CPCs. [ABSTRACT FROM AUTHOR]