Search

Your search keyword '"Tomáš Hyánek"' showing total 3 results
Start Over Author "Tomáš Hyánek"
3 results on '"Tomáš Hyánek"'

1. Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March-October 2020: An exploratory analysis.

Author

Martin Modrák, Paul-Christian Bürkner, Tomáš Sieger, Tomáš Slisz, Martina Vašáková, Grigorij Mesežnikov, Luis Fernando Casas-Mendez, Jaromír Vajter, Jan Táborský, Viktor Kubricht, Daniel Suk, Jan Horejsek, Martin Jedlička, Adriana Mifková, Adam Jaroš, Miroslav Kubiska, Jana Váchalová, Robin Šín, Markéta Veverková, Zbyšek Pospíšil, Julie Vohryzková, Rebeka Pokrievková, Kristián Hrušák, Kristína Christozova, Vianey Leos-Barajas, Karel Fišer, and Tomáš Hyánek

Subjects
Medicine, Science
Abstract

We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2 during the early phases of the pandemic in March-October 2020. The dataset contains baseline patient characteristics, breathing support required, pharmacological treatment received and multiple markers on daily resolution. Patients in the dataset were treated with hydroxychloroquine (N = 108), azithromycin (N = 72), favipiravir (N = 9), convalescent plasma (N = 7), dexamethasone (N = 4) and remdesivir (N = 3), often in combination. To explore association between treatments and patient outcomes we performed multiverse analysis, observing how the conclusions change between defensible choices of statistical model, predictors included in the model and other analytical degrees of freedom. Weak evidence to constrain the potential efficacy of azithromycin and favipiravir can be extracted from the data. Additionally, we performed external validation of several proposed prognostic models for Covid-19 severity showing that they mostly perform unsatisfactorily on our dataset.

Published
2021
Full Text
View/download PDF

2. COVID-19 severe pneumonia: Prospective multicentre study on demands on intensive care capacities

Author

Michal Moravec, Tomáš Hyánek, Olga Džupová, Jiří Beneš, Frantisek Mosna, Hynek Bartoš, Zdeňka Krupková, Jan Berousek, Tomáš Tencer, Tomas Vymazal, and Peter Brestovanský

Subjects
Adult, Male, medicine.medical_specialty, Critical Care, medicine.medical_treatment, Population, law.invention, law, Intensive care, Extracorporeal membrane oxygenation, Humans, Medicine, Hospital Mortality, Prospective Studies, Renal replacement therapy, education, Aged, education.field_of_study, SARS-CoV-2, business.industry, Public Health, Environmental and Occupational Health, Acute kidney injury, COVID-19, General Medicine, medicine.disease, Intensive care unit, Respiratory failure, Emergency medicine, Female, business, Kidney disease
Abstract

OBJECTIVES: The aim of the study was to obtain data on demands on the intensive care capacities to treat COVID-19 patients, and to identify predictors for in-hospital mortality. METHODS: The prospective observational multicentre study carried out from 1 March till 30 June 2020 included adult patients with confirmed SARS-CoV-2 infection with respiratory failure requiring ventilatory support or high-flow nasal oxygen therapy (HFNO). RESULTS: Seventy-four patients, 46 males and 28 females, median age 67.5 (Q1-Q3: 56-75) years, were included. Sixty-four patients (86.5%) had comorbidity. Sixty-six patients (89.2%) were mechanically ventilated, four of them received extracorporeal membrane oxygenation therapy. Eight patients (10.8%) were treated with non-invasive ventilation and HFNO only. The median of intensive care unit (ICU) stay was 22.5 days. Eighteen patients (24.3%) needed continuous renal replacement therapy. Thirty patients (40.5%) died. Age and acute kidney injury were identified as independent predictors of in-hospital death, and chronic kidney disease showed trend towards statistical significance for poor outcome. CONCLUSIONS: Sufficient number of intensive care beds, organ support equipment and well-trained staff is a decisive factor in managing the COVID-19 epidemic. The study focused on the needs of intensive care in the COVID-19 patients. Advanced age and acute kidney injury were identified as independent predictors for in-hospital mortality. When compared to clinical course and ICU management of patients with severe community-acquired pneumonia caused by other pathogens, we observed prolonged need for ventilatory support, high rate of progression to acute respiratory distress syndrome and significant mortality in studied population.

Published
2021
Full Text
View/download PDF

3. NEKROTIZUJÍCÍ INFEKCE MĚKKÝCH TKÁNÍ A MOŽNOSTI LÉČBY HYPERBARICKÝM KYSLÍKEM.

Author

Tomáš, HYÁNEK and Anežka, TURNOVCOVÁ

Abstract

Copyright of Zdravotnicke listy is the property of Alexander Dubcek University in Trencin, Faculty of Nursing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

Catalog

Books, media, physical & digital resources
See catalog results