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2. Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function

Author

Arnaud Ancion, Ciro Santoro, Roberto M. Lang, Krasimira Hristova, Dragos Vinereanu, Patrizio Lancellotti, Marie Moonen, Maurizio Galderisi, George Kacharava, José Luis Zamorano, Daniele Barone, Andreas Hagendorff, Julien Magne, Christophe Martinez, Bernard Cosyns, Nico Van de Veire, Monica Baroni, Tolga Ozyigit, Toshimitsu Tsugu, Nuno Cardim, Raluca Elena Dulgheru, Ralph Stephan von Bardeleben, Gonzalo de la Morena, Concetta Zito, Scipione Carerj, Luigi P. Badano, Elena Galli, Martin Penicka, George Athanassopoulos, Bogdan A. Popescu, Erwan Donal, Jose David Rodrigo Carbonero, Adriana Postolache, Federica Ilardi, Monica Rosca, Teresa López, Andreea Calin, Marianna Cicenia, Tadafumi Sugimoto, Roberta Manganaro, Stella Marchetta, Clinical sciences, Cardio-vascular diseases, Cardiology, Manganaro, Roberta, Marchetta, Stella, Dulgheru, Raluca, Sugimoto, Tadafumi, Tsugu, Toshimitsu, Ilardi, Federica, Cicenia, Marianna, Ancion, Arnaud, Postolache, Adriana, Martinez, Christophe, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andrea, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Drago, Zamorano, Jose Lui, Rosca, Monica, Calin, Andreea, Moonen, Marie, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Carerj, Scipione, Zito, Concetta, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi P, Lang, Roberto M, Lancellotti, Patrizio, Centre Hospitalier Universitaire de Liège (CHU-Liège), Service de cardiologie [Liège], CHU de Liège-Domaine Universitaire du Sart Tilman, Universität Leipzig [Leipzig], Hospital Univeristario Virgen de la Arrixaca, Johannes Gutenberg - Universität Mainz (JGU), University and Emergency Hospital, Universidad de Alcalá - University of Alcalá (UAH), Service de cardiologie [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Academisch Ziekenhuis Vrije Universiteit Brussel, Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Messina, Università degli studi di Napoli Federico II, GE Healthcare and Philips Healthcare, Service de cardiologie et maladies vasculaires, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de cardiologie et maladies vasculaires [CHU de Rennes], Manganaro, R, Marchetta, S, Dulgheru, R, Sugimoto, T, Tsugu, T, Ilardi, F, Cicenia, M, Ancion, A, Postolache, A, Martinez, C, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Moonen, M, Magne, J, Cosyns, B, Galli, E, Donal, E, Carerj, S, Zito, C, Santoro, C, Galderisi, M, Badano, L, Lang, R, and Lancellotti, P

Subjects
Adult, Male, medicine.medical_specialty, Systole, adult echocardiography, Diastole, Speckle tracking echocardiography, 030204 cardiovascular system & hematology, myocardial strain, myocardial work, speckle tracking echocardiography, Ventricular Function, Left, Correlation, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Ejection fraction, business.industry, Work (physics), Stroke Volume, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, General Medicine, Middle Aged, medicine.anatomical_structure, Blood pressure, Echocardiography, Ventricle, Cardiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Cardiology and Cardiovascular Medicine, business
Abstract

Aims The present study sought to evaluate the correlation between indices of non-invasive myocardial work (MW) and left ventricle (LV) size, traditional and advanced parameters of LV systolic and diastolic function by 2D echocardiography (2DE). Methods and results A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from LV pressure-strain loops using custom software. Peak LV pressure was estimated non-invasively from brachial artery cuff pressure. LV size, parameters of systolic and diastolic function and ventricular-arterial coupling were measured by echocardiography. As advanced indices of myocardial performance, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were obtained. On multivariable analysis, GWI was significantly correlated with GLS (standardized beta-coefficient = −0.23, P Conclusion The non-invasive MW indices show a good correlation with traditional 2DE parameters of myocardial systolic function and myocardial strain.

Published
2020
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3. Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

Author

Erwan Donal, Ralph Stephan von Bardeleben, Jose David Rodrigo Carbonero, Maurizio Galderisi, Simona Sperlongano, Monica Rosca, Caroline Piette, Roberta Manganaro, Daniele Barone, Adriana Postolache, Gonzalo de la Morena, Ciro Santoro, Federica Ilardi, Teresa López, George Kacharava, Bogdan A. Popescu, Monica Baroni, Elena Galli, Patrizio Lancellotti, Toshimitsu Tsugu, Julien Magne, Yun Yun Go, Dragos Vinereanu, Nuno Cardim, Marie Moonen, Julien Tridetti, Andreea Calin, José Luis Zamorano, Tolga Ozyigit, Krasimira Hristova, Martin Penicka, Mai-Linh Nguyen Trung, Bernard Cosyns, Raluca Elena Dulgheru, Alexandra Maria Chitroceanu, Tadafumi Sugimoto, George Athanassopoulos, Luigi P. Badano, Nico Van de Veire, Roberto M. Lang, Andreas Hagendorff, Tsugu, Toshimitsu, Postolache, Adriana, Dulgheru, Raluca, Sugimoto, Tadafumi, Tridetti, Julien, Nguyen Trung, Mai-Linh, Piette, Caroline, Moonen, Marie, Manganaro, Roberta, Ilardi, Federica, Chitroceanu, Alexandra Maria, Sperlongano, Simona, Go, Yun Yun, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andrea, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Drago, Zamorano, Jose Lui, Rosca, Monica, Calin, Andreea, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi P, Lang, Roberto M, Lancellotti, Patrizio, Tsugu, T., Postolache, A., Dulgheru, R., Sugimoto, T., Tridetti, J., Trung, M. -L. N., Piette, C., Moonen, M., Manganaro, R., Ilardi, F., Chitroceanu, A. M., Sperlongano, S., Go, Y. Y., Kacharava, G., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., Hristova, K., Lopez, T., de la Morena, G., Popescu, B. A., Penicka, M., Ozyigit, T., Carbonero, J. D. R., van de Veire, N., von Bardeleben, R. S., Vinereanu, D., Zamorano, J. L., Rosca, M., Calin, A., Magne, J., Cosyns, B., Galli, E., Donal, E., Santoro, C., Galderisi, M., Badano, L. P., Lang, R. M., Lancellotti, P., Clinical sciences, Cardio-vascular diseases, Cardiology, GIGA [Université Liège], Université de Liège, CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), GE Healthcare and Philips Healthcare, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Tsugu, T, Postolache, A, Dulgheru, R, Sugimoto, T, Tridetti, J, Nguyen Trung, M, Piette, C, Moonen, M, Manganaro, R, Ilardi, F, Chitroceanu, A, Sperlongano, S, Go, Y, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Magne, J, Cosyns, B, Galli, E, Donal, E, Santoro, C, Galderisi, M, Badano, L, Lang, R, and Lancellotti, P

Subjects
Adult, Male, medicine.medical_specialty, adult echocardiography, deformation imaging, Heart Ventricles, 030204 cardiovascular system & hematology, Ventricular Function, Left, Reference values, 2D echocardiography, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, reference values, Healthy volunteers, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Endocardium, Normal range, Strain (chemistry), business.industry, Myocardium, Healthy subjects, reference value, Mean age, General Medicine, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Middle Aged, Apex (geometry), Echocardiography, Cardiology, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Female, business, Large group, Cardiology and Cardiovascular Medicine, Human
Abstract

Aims To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. Methods and results A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were −15.0% in men and −15.6% in women for epicardial strain, −16.8% and −17.7% for mid-myocardial strain, and −18.7% and −19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = −0.20, P = 0.007, mid-myocardial; r = −0.21, P = 0.006, endocardial; r = −0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1). Conclusion The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.

Published
2020
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4. Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study

Author

Stella Marchetta, Anne Bernard, Ralph Stephan von Bardeleben, Elena Galli, Tadafumi Sugimoto, Concetta Zito, Maurizio Galderisi, Sébastien Robinet, Daniele Barone, Sara Cimino, Monica Baroni, Tolga Ozyigit, Yun Yun Go, Bernard Cosyns, Roberta Manganaro, Marie Moonen, Ciro Santoro, George Athanassopoulos, Gonzalo de la Morena, Scipione Carerj, Andreas Hagendorff, Erwan Donal, José Luis Zamorano, Nico Van de Veire, Federica Ilardi, Patrizio Lancellotti, Dragos Vinereanu, Bogdan A. Popescu, Monica Rosca, Raluca Elena Dulgheru, Krasimira Hristova, Nuno Cardim, Jose David Rodrigo Carbonero, Roberto M. Lang, Teresa López-Fernández, Luigi P. Badano, Andreea Calin, Cécile Oury, Julien Magne, Martin Penicka, George Kacharava, Clinical sciences, Cardio-vascular diseases, Cardiology, Manganaro, R, Marchetta, S, Dulgheru, R, Ilardi, F, Sugimoto, T, Robinet, S, Cimino, S, Go, Y, Bernard, A, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, López-Fernández, T, de la Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, van de Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Rosca, M, Calin, A, Moonen, M, Magne, J, Cosyns, B, Galli, E, Donal, E, Carerj, S, Zito, C, Santoro, C, Galderisi, M, Badano, L, Lang, R, Oury, C, Lancellotti, P, Centre Hospitalier Universitaire de Liège (CHU-Liège), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Universität Leipzig [Leipzig], Universidad de Alcalá - University of Alcalá (UAH), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel (VUB), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Messina, GE Healthcare, EACVI Research and Innovation Committee, Heart House, NORRE, Philips Healthcare, Manganaro, R., Marchetta, S., Dulgheru, R., Ilardi, F., Sugimoto, T., Robinet, S., Cimino, S., Go, Y. Y., Bernard, A., Kacharava, G., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., Hristova, K., Lopez-Fernandez, T., De La Morena, G., Popescu, B. A., Penicka, M., Ozyigit, T., Rodrigo Carbonero, J. D., Van De Veire, N., Von Bardeleben, R. S., Vinereanu, D., Zamorano, J. L., Rosca, M., Calin, A., Moonen, M., Magne, J., Cosyns, B., Galli, E., Donal, E., Carerj, S., Zito, C., Santoro, C., Galderisi, M., Badano, L. P., Lang, R. M., Oury, C., Lancellotti, P., Universität Leipzig, and Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, medicine.medical_specialty, adult echocardiography, Work efficiency, 030204 cardiovascular system & hematology, 2D echocardiography, 03 medical and health sciences, 0302 clinical medicine, Reference Values, Internal medicine, medicine.artery, Healthy volunteers, Medicine, Humans, Radiology, Nuclear Medicine and imaging, myocardial work, reference values, Prospective Studies, Brachial artery, adult echocardiography • 2D echocardiography • myocardial work • reference values, business.industry, Non invasive, Healthy subjects, reference value, Mean age, General Medicine, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Middle Aged, Europe, Blood pressure, Echocardiography, Heart Function Tests, Cardiology, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Cardiology and Cardiovascular Medicine, business, Large group, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; Aims - To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results - A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270 mmHg% and 1310 mmHg% for GWI, 1650 mmHg% and 1544 mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238 mmHg% in men and 239 mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. Conclusion - The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.

Published
2019
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5. Echocardiographic reference ranges for normal left atrial function parameters results from the EACVI NORRE study

Author

Tadafumi, Sugimoto, Sébastien, Robinet, Raluca, Dulgheru, Anne, Bernard, Federica, Ilardi, Laura, Contu, Karima, Addetia, Luis, Caballero, George, Kacharava, George D, Athanassopoulos, Daniele, Barone, Monica, Baroni, Nuno, Cardim, Andreas, Hagendorff, Krasimira, Hristova, Teresa, Lopez, Gonzalo, de la Morena, Bogdan A, Popescu, Martin, Penicka, Tolga, Ozyigit, Jose David, Rodrigo Carbonero, Nico, van de Veire, Ralph Stephan, Von Bardeleben, Dragos, Vinereanu, Jose Luis, Zamorano, Yun Yun, Go, Stella, Marchetta, Alain, Nchimi, Monica, Rosca, Andreea, Calin, Marie, Moonen, Sara, Cimino, Julien, Magne, Bernard, Cosyns, Elena, Galli, Erwan, Donal, Gilbert, Habib, Roberta, Esposito, Maurizio, Galderisi, Luigi P, Badano, Roberto M, Lang, Patrizio, Lancellotti, Centre Hospitalier Universitaire de Liège (CHU-Liège), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hospital Univeristario Virgen de la Arrixaca, Onassis Cardiac Surgery Center [Athens] (OCSC), Universität Leipzig [Leipzig], Universidad de Alcalá - University of Alcalá (UAH), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia], Universität Leipzig, CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinical sciences, Cardio-vascular diseases, Cardiology, Sugimoto, T, Robinet, S, Dulgheru, R, Bernard, A, Ilardi, F, Contu, L, Addetia, K, Caballero, L, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Go, Y, Marchetta, S, Nchimi, A, Rosca, M, Calin, A, Moonen, M, Cimino, S, Magne, J, Cosyns, B, Galli, E, Donal, E, Habib, G, Esposito, R, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Sugimoto, Tadafumi, Robinet, Sébastien, Dulgheru, Raluca, Bernard, Anne, Ilardi, Federica, Contu, Laura, Addetia, Karima, Caballero, Lui, Kacharava, George, Athanassopoulos, George D, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andrea, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Drago, Zamorano, Jose Lui, Go, Yun Yun, Marchetta, Stella, Nchimi, Alain, Rosca, Monica, Calin, Andreea, Moonen, Marie, Cimino, Sara, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Habib, Gilbert, Esposito, Roberta, Galderisi, Maurizio, Badano, Luigi P, Lang, Roberto M, and Lancellotti, Patrizio

Subjects
Male, deformation imaging, Pump function, Echocardiography, Three-Dimensional, Sex Factor, 030204 cardiovascular system & hematology, Cohort Studies, 0302 clinical medicine, Left atrial, Reference Values, Healthy volunteers, Image Processing, Computer-Assisted, Age Factor, adult echocardiography, left atrial function, reference values, 030212 general & internal medicine, Multivariate Analysi, Observer Variation, Healthy subjects, Age Factors, General Medicine, Middle Aged, Reference Standards, Healthy Volunteer, Healthy Volunteers, Homogeneous, Radiology Nuclear Medicine and imaging, Echocardiography, Cardiology, Linear Model, Atrial Function, Left, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Cardiology and Cardiovascular Medicine, Human, Adult, medicine.medical_specialty, Statistics, Nonparametric, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Heart Atria, Left atrial function, business.industry, reference value, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Reference values, Multivariate Analysis, Linear Models, Reference Standard, Parameter, Cohort Studie, Large group, business
Abstract

International audience; Aims - To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender. Methods and results - A total of 371 (median age 45 years) healthy subjects were enrolled at 22 collaborating institutions collaborating in the Normal Reference Ranges for Echocardiography (NORRE) study of the European Association of Cardiovascular Imaging (EACVI). Left atrial data sets were analysed with a vendor-independent software (VIS) package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire data sets. The lowest expected values of LA function were 26.1%, 48.7%, and 41.4% for left atrial strain (LAS), 2D left atrial emptying fraction (LAEF), and 3D LAEF (reservoir function); 7.7%, 24.2%, and -0.53/s for LAS-active, LAEF-active, and LA strain rate during LA contraction (SRa) (pump function) and 12.0% and 21.6% for LAS-passive and LAEF-passive (conduit function). Left atrial reservoir and conduit function were decreased with age while pump function was increased. All indices of reservoir function and all LA strains had no difference in both gender and vendor. However, inter-vendor differences were observed in LA SRa despite the use of VIS. Conclusion - The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function. Our data highlight the importance of age-specific reference values for LA functions.

Published
2018
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6. Echocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study

Author

Ralph Stephan von Bardeleben, José Luis Zamorano, Jose David Rodrigo Carbonero, Maurizio Galderisi, Daniele Barone, Monica Baroni, Erwan Donal, Gonzalo de la Morena, Krasimira Hristova, Federica Ilardi, Tolga Ozyigit, Laura Contu, Anne Bernard, Natela Akhaladze, Martin Penicka, Yun Yun Go, Nico Van de Veire, Karima Addetia, Stella Marchetta, Bernard Cosyns, Nuno Cardim, Luis Caballero, Julien Magne, Roberto M. Lang, Dragos Vinereanu, Raluca Elena Dulgheru, Luigi P. Badano, Patrizio Lancellotti, Andreas Hagendorff, Andrea Calin, Tadafumi Sugimoto, Monica Rosca, Gilbert Habib, George Athanassopoulos, Bogdan A. Popescu, Marie Moonen, Teresa López, Cardio-vascular diseases, Clinical sciences, Faculty of Medicine and Pharmacy, Centre Hospitalier Universitaire de Liège (CHU-Liège), Universität Leipzig [Leipzig], Johannes Gutenberg - Universität Mainz (JGU), Universidad de Alcalá - University of Alcalá (UAH), CHU Dupuytren, Academisch Ziekenhuis Vrije Universiteit Brussel, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Universita degli Studi di Padova, University of Chicago, GE Healthcare, Philips Healthcare, Universität Leipzig, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Padova = University of Padua (Unipd), Sugimoto, T, Dulgheru, R, Bernard, A, Ilardi, F, Contu, L, Addetia, K, Caballero, L, Akhaladze, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, De La Morena, G, Popescu, B, Moonen, M, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Go, Y, Rosca, M, Calin, A, Magne, J, Cosyns, B, Marchetta, S, Donal, E, Habib, G, Galderisi, M, Badano, L, Lang, R, Lancellotti, P, Sugimoto, Tadafumi, Dulgheru, Raluca, Bernard, Anne, Ilardi, Federica, Contu, Laura, Addetia, Karima, Caballero, Lui, Akhaladze, Natela, Athanassopoulos, George D., Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andrea, Hristova, Krasimira, Lopez, Teresa, De La Morena, Gonzalo, Popescu, Bogdan A., Moonen, Marie, Penicka, Martin, Ozyigit, Tolga, Carbonero, Jose David Rodrigo, Van De Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Drago, Zamorano, Jose Lui, Go, Yun Yun, Rosca, Monica, Calin, Andrea, Magne, Julien, Cosyns, Bernard, Marchetta, Stella, Donal, Erwan, Habib, Gilbert, Galderisi, Maurizio, Badano, Luigi P., Lang, Roberto M., and Lancellotti, Patrizio

Subjects
Male, Longitudinal strain, deformation imaging, [SDV]Life Sciences [q-bio], Sex Factor, 030204 cardiovascular system & hematology, Standard deviation, Ventricular Function, Left, Heart Ventricle, 2D echocardiography, 0302 clinical medicine, Reference Values, Nuclear Medicine and Imaging, Image Processing, Computer-Assisted, Medicine, Circumferential strain, Age Factor, Reference Value, 030212 general & internal medicine, Multivariate Analysi, Adult echocardiography, Deformation imaging, Reference values, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, Observer Variation, Strain (chemistry), Age Factors, General Medicine, Middle Aged, Healthy Volunteer, Healthy Volunteers, Europe, Homogeneous, Echocardiography, Radiology Nuclear Medicine and imaging, Cardiology, Linear Model, Female, Radiology, Radial stress, Human, Adult, medicine.medical_specialty, adult echocardiography, Heart Ventricles, 03 medical and health sciences, Sex Factors, Internal medicine, Humans, Radiology, Nuclear Medicine and imaging, 2d strain, business.industry, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Multivariate Analysis, Linear Models, business
Abstract

International audience; Aims - To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results - A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean were -16.7% in men and -17.8% in women for longitudinal strain, -22.3% and -23.6% for circumferential strain, 20.6% and 21.5% for radial strain, and 2.2 degrees and 1.9 degrees for twist, respectively. In multivariable analysis, longitudinal strain decreased with age whereas the opposite occurred with circumferential and radial strain. Male gender was associated with lower strain for longitudinal, circumferential, and radial strain. Inter-vendor differences were observed for circumferential and radial strain despite the use of vendor-independent software. Importantly, no intervendor differences were noted in longitudinal strain. Conclusion - The NORRE study provides contemporary, applicable 2D echocardiographic reference ranges for LV longitudinal, radial, and circumferential strain. Our data highlight the importance of age- and gender-specific reference values for LV strain.

Published
2017
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7. Blood pressure profile is associated with microalbuminuria and retinopathy in hypertensive nondiabetic patients

Author

Tolga Ozyigit, Berrin Karadag, Beste Ozben, Zeliha Serindag, and Aysegul Ilhan

Subjects
Adult, Male, medicine.medical_specialty, Ambulatory blood pressure, Physical examination, Blood Pressure, Hypertensive Retinopathy, 030204 cardiovascular system & hematology, Risk Assessment, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Hypertensive retinopathy, Internal medicine, medicine, Albuminuria, Humans, 030212 general & internal medicine, Aged, medicine.diagnostic_test, business.industry, Age Factors, General Medicine, Middle Aged, medicine.disease, Blood pressure, Cohort, Hypertension, Cardiology, Microalbuminuria, Female, business, Retinopathy
Abstract

Target organ damage is important for global cardiovascular risk assessment. The aim of this study was to explore the association between the blood pressure profile and end-organ damage in a hypertensive non-diabetic cohort. A total of 560 consecutive hypertensive nondiabetic patients (mean age: 58.2 ± 13.3 years, 221 men) were included in the study. All patients underwent thorough physical examination including fundoscopic examination. First morning urine samples were obtained from each patient and measurement of the albumin-to-creatinine ratio in first morning urine collection samples was used for diagnosis of microalbuminuria. All patients underwent a 24-h ambulatory blood pressure monitoring and were grouped as dippers and non-dippers according to the presence or absence of >10% decrease in blood pressure during the night, respectively. The non-dipper group consisted of 247 patients with a non-dipper blood pressure profile, 31 patients with reverse dipping and 4 patients with extreme dipping. Non-dipper patients were significantly older. Coronary artery disease, cerebrovascular disease, hypertensive retinopathy and microalbuminuria were significantly more prevalent in the non-dipper patients. Non-dipping hypertension increased the risk of hypertensive retinopathy by 1.89 times (95% confidence interval, CI:1.35–2.65, p < 0.001) and the risk of microalbuminuria by 2.23 times (95% CI:1.49–3.33, p < 0.001). Non-dipping hypertension was still significantly associated with hypertensive retinopathy and microalbuminuria when adjusted by age and sex. Non-dipping hypertension was associated with increased risk of hypertensive retinopathy and microalbuminuria. Blood pressure profiles should also be considered in assessing the risk for hypertensive patients.

Published
2017

8. 3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study

Author

Nico Van de Veire, Erwan Donal, Dragos Vinereanu, Federica Ilardi, Tolga Ozyigit, Christophe Martinez, Karima Addetia, Anne Bernard, José Luis Zamorano, Julien Magne, Andreas Hagendorff, Daniele Barone, Teresa López, Jose David Rodrigo Carbonero, Gonzalo de la Morena, Roberto M. Lang, George Athanassopoulos, Nuno Cardim, Monica Baroni, Luigi P. Badano, Ralph Stephan von Bardeleben, Bernard Cosyns, Natela Akhaladze, Martin Penicka, Patrizio Lancellotti, Tadafumi Sugimoto, Gilbert Habib, Raluca Elena Dulgheru, Krasimira Hristova, Bogdan A. Popescu, Luis Caballero, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), University of Chicago, Cardio-vascular diseases, Clinical sciences, Bernard, A., Addetia, K., Dulgheru, R., Caballero, L., Sugimoto, T., Akhaladze, N., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., Hristova, K., Ilardi, F., Lopez, T., De La Morena, G., Popescu, B. A., Penicka, M., Ozyigit, T., Carbonero, J. D. R., Van De Veire, N., Von Bardeleben, R. S., Vinereanu, D., Zamorano, J. L., Martinez, C., Magne, J., Cosyns, B., Donal, E., Habib, G., Badano, L. P., Lang, R. M., Lancellotti, P., Bernard, A, Addetia, K, Dulgheru, R, Caballero, L, Sugimoto, T, Akhaladze, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Ilardi, F, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Martinez, C, Magne, J, Cosyns, B, Donal, E, Habib, G, Badano, L, Lang, R, Lancellotti, P, Hospital Virgen de la Arrixaca, Murcia, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, Longitudinal strain, adult echocardiography, deformation imaging, Heart Ventricles, Cardiac Volume, Diastole, Echocardiography, Three-Dimensional, 030204 cardiovascular system & hematology, Ventricular Function, Left, Heart Ventricle, Reference values, 03 medical and health sciences, Young Adult, left ventricular function, 0302 clinical medicine, Internal medicine, Healthy volunteers, three-dimensional echocardiography, Medicine, Circumferential strain, Humans, Radiology, Nuclear Medicine and imaging, Reference Value, 030212 general & internal medicine, Systole, Aged, Ejection fraction, Strain (chemistry), business.industry, General Medicine, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Middle Aged, Healthy Volunteer, Healthy Volunteers, 3. Good health, Radiology Nuclear Medicine and imaging, Cardiology, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, business, Cardiology and Cardiovascular Medicine, Human
Abstract

International audience; Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2) than in women (82 and 35 mL/m2; P

Published
2017
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9. Relationship between left atrial volume index and cognitive decline in elderly patients with sinus rhythm

Author

Semra Kayaoglu, Tolga Ozyigit, Berrin Karadag, Beste Ozben, and Yuksel Altuntas

Subjects
Male, medicine.medical_specialty, Severity of Illness Index, Predictive Value of Tests, Physiology (medical), Internal medicine, medicine, Humans, Dementia, Arrhythmia, Sinus, Sinus rhythm, Heart Atria, Cognitive decline, Stroke, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, Body surface area, Mini–Mental State Examination, medicine.diagnostic_test, business.industry, Body Surface Potential Mapping, Atrial fibrillation, Cognition, General Medicine, medicine.disease, Neurology, Echocardiography, Anesthesia, Cardiology, Female, Surgery, Neurology (clinical), Cognition Disorders, business
Abstract

Left atrial (LA) enlargement is a predictor of cardiovascular outcomes such as atrial fibrillation (AF), stroke, and death. The aim of this study was to explore the relationship between LA size and cognitive function in elderly patients without any signs of clinical dementia, AF or previous stroke. We assessed the cognitive status and LA volume (LAV) of 108 consecutive patients (27 males; mean age, 74.8 ± 6.9 years) with sinus rhythm. Cognitive status was assessed by the Mini Mental State Examination (MMSE). Patients with a MMSE score of ⩽25 were considered to have cognitive impairment. LAV was measured with two-dimensional echocardiography. LAV index (LAVI) was obtained by indexing LAV to body surface area. Thirty-five patients (32.4%) had cognitive impairment. The patients with cognitive impairment had significantly larger left atria than the patients with normal cognitive function. Receiver operating characteristic analysis revealed a cut-off point of ⩾34 mL/m 2 for LAVI to predict patients with cognitive impairment (sensitivity, 97.1%; specificity, 52.1%; positive predictive value, 49.3%; negative predictive value, 97.4%). LAVI ⩾ 34 mL/m 2 was significantly associated with cognitive impairment ( p = 0.001, odds ratio = 36.91, 95% confidence interval = 4.8–284.2). Logistic regression analysis revealed that LAVI ⩾ 34 mL/m 2 and age were independently associated with cognitive impairment. Increased LAVI is associated with cognitive impairment. Assessment of cognitive function may be recommended in elderly patients with enlarged left atria.

Published
2013
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10. Two-dimensional transthoracic echocardiographic normal reference ranges for proximal aorta dimensions: Results from the EACVI NORRE study

Author

Teresa López, Nico Van de Veire, Daniele Barone, Ralph Stephan von Bardeleben, Bogdan A. Popescu, Monica Baroni, Erwan Donal, Jose David Rodrigo Carbonero, Dragos Vinereanu, Roberto M. Lang, Ann-Stephan Gori, Luigi P. Badano, Gonzalo de la Morena, Seisyou Kou, Martin Penicka, Tolga Ozyigit, Gilbert Habib, Natalia Gonjilashvili, Karima Addetia, Krasimira Hristova, Patrizio Lancellotti, George Athanassopoulos, Nuno Cardim, José Luis Zamorano, Anne Bernard, Andreas Hagendorff, Bernard Cosyns, Luis Caballero, Raluca Elena Dulgheru, Daniel Saura, Saura, D, Dulgheru, R, Caballero, L, Bernard, A, Kou, S, Gonjilashvili, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Carbonero, J, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Zamorano, J, Gori, A, Cosyns, B, Donal, E, Habib, G, Addetia, K, Lang, R, Badano, L, Lancellotti, P, Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia], Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Service de cardiologie, Cardiology, University and Emergency Hospital, CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), GE Healthcare and Philips Healthcare, Hospital Virgen de la Arrixaca, Murcia, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardio-vascular diseases, Clinical sciences, and Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)

Subjects
Male, Aorta, Thoracic, Sex Factor, 030204 cardiovascular system & hematology, Reproducibility of result, Cohort Studies, 0302 clinical medicine, Diastole, Medicine, Thoracic aorta, Age Factor, Reference Value, Prospective Studies, 030212 general & internal medicine, Multivariate Analysi, Body surface area, Cardiac cycle, Age Factors, General Medicine, NORRE study, Middle Aged, Healthy Volunteer, Healthy Volunteers, Europe, Echocardiography, echocardiography, reference values, reproducibility of results, sinus of valsalva, thoracic aorta, Cardiology, Linear Model, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Female, Cardiology and Cardiovascular Medicine, Human, Adult, medicine.medical_specialty, Systole, Normal values, Reference values, 03 medical and health sciences, Young Adult, Sex Factors, Internal medicine, medicine.artery, Ascending aorta, Humans, Radiology, Nuclear Medicine and imaging, Measurement method, Aorta, Analysis of Variance, business.industry, Sinus of valsalva, Reproducibility of Results, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Prospective Studie, Multivariate Analysis, Linear Models, Cohort Studie, business
Abstract

International audience; AIMS: To report normal reference ranges for echocardiographic dimensions of the proximal aorta obtained in a large group of healthy volunteers recruited using state-of-the-art cardiac ultrasound equipment, considering different measurement conventions, and taking into account gender, age, and body size of individuals. METHODS AND RESULTS: A total of 704 (mean age: 46.0 ± 13.5 years) healthy volunteers (310 men and 394 women) were prospectively recruited from the collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was obtained in all subjects following pre-defined protocols. Aortic dimensions were obtained in systole and diastole, following both the leading-edge to leading-edge and the inner-edge to inner-edge conventions. Diameters were measured at four levels: ventricular-arterial junction, sinuses of Valsalva, sino-tubular junction, and proximal tubular ascending aorta. Measures of aortic root in the short-axis view following the orientation of each of the three sinuses were also performed. Men had significantly larger body sizes when compared with women, and showed larger aortic dimensions independently of the measurement method used. Dimensions indexed by height and body surface area are provided, and stratification by age ranges is also displayed. In multivariable analysis, the independent predictors of aortic dimensions were age, gender, and height or body surface area. CONCLUSION: The NORRE study provides normal values of proximal aorta dimensions as assessed by echocardiography. Reference ranges for different anatomical levels using different (i) measurement conventions and (ii) at different times of the cardiac cycle (i.e. mid-systole and end-diastole) are provided. Age, gender, and body size were significant determinants of aortic dimensions

Published
2017
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11. Three dimensional left atrial volume index is correlated with P wave dispersion in elderly patients with sinus rhythm

Author

Tolga Ozyigit, Beste Ozben, Berrin Karadag, and Onur Kocas

Subjects
Male, medicine.medical_specialty, Turkey, Echocardiography, Three-Dimensional, 030204 cardiovascular system & hematology, Risk Assessment, Sensitivity and Specificity, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Heart Rate, Risk Factors, Internal medicine, Heart Rate Determination, Heart rate, Atrial Fibrillation, medicine, Prevalence, Humans, Sinus rhythm, Statistical dispersion, 030212 general & internal medicine, Heart Atria, Geriatric Assessment, Aged, P wave dispersion, medicine.diagnostic_test, business.industry, P wave, Reproducibility of Results, Atrial fibrillation, General Medicine, Organ Size, medicine.disease, Volume (thermodynamics), Cardiology, Female, business
Abstract

P wave dispersion is a noninvasive electrocardiographic predictor for atrial fibrillation. The aim of the study was to explore relation between left atrial volume index assessed by 3-dimensional echocardiography and P wave dispersion in elderly patients.Seventy-three consecutive patients over the age of 65 (mean age: 75 ± 7 years, 17 men) were included. P wave dispersion is calculated as the difference between maximum and minimum P wave durations. Left atrial volume index was measured by both 2-dimensional and 3-dimensional echocardiography and categorized as normal (≤ 34 mL/m(2)) or increased (mild, 35-41 mL/m(2); moderate, 42-48 mL/m(2); severe, ≥ 49 mL/m(2)).Thirty-one patients had normal left atrium while 24 patients had mildly enlarged, nine had moderately enlarged, and nine had severely enlarged left atrium. Prolongation of P wave dispersion was more prevalent in patients with dilated left atrium. P wave dispersion was significantly correlated with both 2-dimensional (r = 0.600, p 0.001) and 3-dimensional left atrial volume index (r = 0.688, p 0.001). Both left atrial volume indexes were associated with prolonged P wave dispersion when adjusted for age, sex, presence of hypertension, and left ventricular mass index. Receiver-operator characteristic (ROC) analysis revealed that a 3-dimensional left atrial volume index ≥ 25 mL/m(2) separated patients with prolonged P wave dispersion with a sensitivity of 82.2 %, specificity of 67.9 %, positive predictive value of 80.4 %, and negative predictive value of 70.4 %.In elderly patients, 3-dimensional left atrial volume index showed a better correlation with P wave dispersion and might be helpful in discriminating patients with prolonged P wave dispersion, who might be prone to atrial fibrillation.

Published
2015

12. Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study

Author

Anne Bernard, Luigi P. Badano, Raluca Elena Dulgheru, Natalia Gonjilashvili, Daniele Barone, Nico Van de Veire, Dragos Vinereanu, Christophe Martinez, Seisyou Kou, Martin Penicka, Luis Caballero, Andreas Hagendorff, Alessandro Salustri, Monica Baroni, Ralph Stephan von Bardeleben, Julien Magne, Bogdan A. Popescu, Teresa López, José Juan Gómez de Diego, Jens-Uwe Voigt, Erwan Donal, Krasimira Hristova, María J. Oliva, Roberto M. Lang, George Athanassopoulos, Gonzalo de la Morena, Nuno Cardim, Jose David Rodrigo Carbonero, Tolga Ozyigit, José Luis Zamorano, Patrizio Lancellotti, Clinical sciences, Cardio-vascular diseases, Cardiology, University and Emergency Hospital, Service de cardiologie, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Hospital Virgen de la Arrixaca, Murcia, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Caballero, L, Kou, S, Dulgheru, R, Gonjilashvili, N, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, De Diego, J, Oliva, M, Hagendorff, A, Hristova, K, Lopez, T, Magne, J, Martinez, C, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Carbonero, J, Salustri, A, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Voigt, J, Zamorano, J, Bernard, A, Donal, E, Lang, R, Badano, L, and Lancellotti, P

Subjects
Male, Aging, Left, 030204 cardiovascular system & hematology, Doppler echocardiography, Ventricular Function, Left, NORRE Study, Cohort Studies, 0302 clinical medicine, Diastole, Reference Values, Nuclear Medicine and Imaging, Ventricular Function, 030212 general & internal medicine, reference values, systolic and diastolic function, Adult, Age Factors, Aged, Echocardiography, Doppler, Europe, Female, Healthy Volunteers, Heart Ventricles, Humans, Middle Aged, Sex Factors, Systole, Young Adult, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, medicine.diagnostic_test, Doppler, General Medicine, Cardiovascular physiology, medicine.anatomical_structure, Echocardiography, Cardiology, symbols, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Radiology, Doppler effect, Cohort study, medicine.medical_specialty, 03 medical and health sciences, symbols.namesake, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, business.industry, reference value, Ventricle, Reference values, business
Abstract

International audience; AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 ± 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was obtained from all subjects following predefined protocols. The majority of the Doppler diastolic parameters (e', E/e') as well as right ventricle systolic s' wave velocity were similar in men and women. Left ventricle s' wave velocity was higher in men than in women. E wave and e' were higher in younger subjects and decreased progressively in the older ones. E/e' ratio increased with ageing. Septal e' \textless8 cm/s was present in 19.7% of the subjects in the 40-60 year group and in 55% of those in the ≥60 year group. However, the cut-off value of average E/e' or lateral E/e' remained \textless15 or 13, respectively, in the majority of patients. CONCLUSION: The NORRE study provides the reference values for the most useful Doppler parameters in the evaluation of heart physiology. These data highlight the need of using age-specific reference values especially for the diagnosis of LV systolic and diastolic dysfunction and for the estimation of LV filling pressures

Published
2015
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13. Acute Exacerbation Impairs Right Ventricular Function in COPD Patients

Author

Beste, Ozben, Emel, Eryuksel, Azra Meryem, Tanrikulu, Nurdan, Papila, Tolga, Ozyigit, Turgay, Celikel, and Yelda, Basaran

Subjects
Male, Pulmonary Disease, Chronic Obstructive, Risk Factors, Ventricular Dysfunction, Right, Humans, Female, Tricuspid Valve, Middle Aged, Echocardiography, Doppler, Aged
Abstract

Chronic obstructive pulmonary disease (COPD) may impair right ventricular (RV) function. Tissue Doppler imaging (TDI) is helpful in the noninvasive evaluation of RV longitudinal function. The aim of this study was to assess the impact of acute COPD exacerbation on RV function assessed by TDI.The study included 30 COPD patients who had acute exacerbation and 30 controls. RV function was assessed echocardiographically during acute exacerbation and after recovery. In addition to conventional echocardiographic parameters, tricuspid annular plane systolic excursion, tricuspid annulus peak systolic velocity (Sa), and TDI-derived isovolumic myocardial acceleration (IVA) were determined.During exacerbation, COPD patients had a significantly larger RV and higher pulmonary artery systolic pressure, with significantly lower IVA, Sa and tricuspid annular plane systolic excursion compared to controls. After recovery, IVA and Sa significantly increased, while RV diameter and pulmonary artery systolic pressure significantly decreased to levels similar to controls. There were statistically significant, but modest correlations between IVA and Sa (r=0.441, p=0.003), tricuspid annular plane systolic excursion (r=0.628, p0.001), pulmonary artery systolic pressure (r=-0.391, p=0.002) and RV diameter (r=-0.309, p=0.018). Sa correlated with pulmonary artery systolic pressure (r=-0.350, p=0.007) and RV diameter (r=-0.344, p=0.008).COPD exacerbations have a negative impact on RV function. TDI-derived IVA and Sa may be used in the assessment of subclinical RV dysfunction in COPD patients with exacerbation.

Published
2015

14. Acute beneficial effects of smoking cessation on coronary flow reserve: a pilot study

Author

Leyla Pur Ozyigit, Nihat Polat, Caaglar Cuhadaroglu, Erdem Kasikcioglu, Zeki Kilicaslan, Huseyin Oflaz, Arif Oguzhan Cimen, Ahmet Gurdal, and Tolga Ozyigit

Subjects
Adult, Male, medicine.medical_specialty, business.industry, medicine.medical_treatment, Smoking, Coronary flow reserve, Pilot Projects, Coronary Artery Disease, medicine.disease, Echocardiography, Internal medicine, Coronary Circulation, Emergency medicine, medicine, Cardiology, Smoking cessation, Humans, Female, Smoking Cessation, Medical emergency, Cardiology and Cardiovascular Medicine, business, Beneficial effects, Blood Flow Velocity
Published
2014

15. Echocardiographic reference ranges for normal cardiac chamber size: Results from the NORRE study

Author

Daniele Barone, Monica Baroni, Nico Van de Veire, Krasimira Hristova, Seisyou Kou, Christine Henri, Damien Voilliot, George Kacharava, Julien Magne, Luigi P. Badano, José Juan Gómez de Diego, Ralph Stephan von Bardeleben, Dragos Vinereanu, Alessandro Salustri, Martin Penicka, Jens-Uwe Voigt, Andreas Hagendorff, Jose David Rodrigo Carbonero, Roberto M. Lang, Carla de Sousa, Bogdan A. Popescu, George Athanassopoulos, Patrizio Lancellotti, Tolga Ozyigit, Teresa López, Erwan Donal, Nuno Cardim, Gonzalo de la Morena, José Luis Zamorano, Raluca Elena Dulgheru, Luis Caballero, Kou, S, Caballero, L, Dulgheru, R, Voilliot, D, De Sousa, C, Kacharava, G, Athanassopoulos, G, Barone, D, Baroni, M, Cardim, N, Gomez De Diego, J, Hagendorff, A, Henri, C, Hristova, K, Lopez, T, Magne, J, De La Morena, G, Popescu, B, Penicka, M, Ozyigit, T, Rodrigo Carbonero, J, Salustri, A, Van De Veire, N, Von Bardeleben, R, Vinereanu, D, Voigt, J, Zamorano, J, Donal, E, Lang, R, Badano, L, and Lancellotti, P

Subjects
Male, Lower blood pressure, Sex Factor, Heart Ventricle, Cohort Studies, Chamber size and function, Reference values, Two-dimensional echocardiography, Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and Imaging, Medicine (all), Nuclear Medicine and Imaging, Age Factor, Reference Value, Young adult, Body surface area, Observer Variation, Age Factors, General Medicine, Stroke volume, Middle Aged, Echocardiography, Cardiology, Female, Radiology, Human, Cohort study, Adult, medicine.medical_specialty, Heart Ventricles, Reproducibility of Result, Risk Assessment, Young Adult, Sex Factors, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Heart Atria, Aged, business.industry, Reproducibility of Results, Mean age, Stroke Volume, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Original Articles, Cardiac chamber, Cohort Studie, business
Abstract

AimsAvailability of normative reference values for cardiac chamber quantitation is a prerequisite for accurate clinical application of echocardiography. In this study, we report normal reference ranges for cardiac chambers size obtained in a large group of healthy volunteers accounting for gender and age. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following chamber quantitation protocols approved by the European Association of Cardiovascular Imaging.MethodsA total of 734 (mean age: 45.8 ± 13.3 years) healthy volunteers (320 men and 414 women) were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was performed on all subjects following pre-defined protocols. There were no gender differences in age or cholesterol levels. Compared with men, women had significantly smaller body surface areas, and lower blood pressure. Quality of echocardiographic data sets was good to excellent in the majority of patients. Upper and lower reference limits were higher in men than in women. The reference values varied with age. These age-related changes persisted for most parameters after normalization for the body surface area.ConclusionThe NORRE study provides useful two-dimensional echocardiographic reference ranges for cardiac chamber quantification. These data highlight the need for body size normalization that should be performed together with age-and gender-specific assessment for the most echocardiographic parameters. © 2014 The Author.

Published
2014

16. Aliskiren: review of efficacy and safety data with focus on past and recent clinical trials

Author

Selçuk Şen, Soner Sabirli, Yağız Üresin, and Tolga Ozyigit

Subjects
medicine.medical_specialty, business.industry, medicine.drug_class, Medicine (miscellaneous), Reviews, Pharmacology, Aliskiren, Placebo, medicine.disease, Renin inhibitor, Plasma renin activity, Clinical trial, chemistry.chemical_compound, Blood pressure, chemistry, Heart failure, Internal medicine, Medicine, business, Antihypertensive drug
Abstract

Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. Clinical data have substantiated that the antihypertensive effectiveness of aliskiren is similar to that of the other major antihypertensive agents. Furthermore, aliskiren has a similar safety profile to placebo. Combination treatment with aliskiren showed significant blood pressure and proteinuria reductions compared with monotherapy. Aliskiren decreases plasma renin activity in contrast to other renin–angiotensin–aldosterone related drugs. The efficacy of aliskiren in treating major cardiovascular events and the prevention of end-organ damage are being investigated in the ASPIRE HIGHER program. Although the first studies of the ASPIRE HIGHER program such as ALOFT, AVOID, AGELESS showed favorable findings, ASPIRE and AVANT-GARDE studies provided contradictory results. Subsequently, the ALTITUDE study was terminated early because of safety issues and lack of beneficial effects. Most recently, the ASTRONAUT trial showed no reduction in cardiovascular death or heart failure rehospitalization with the addition of aliskiren to standard therapy in patients who were hospitalized for heart failure and with reduced left-ventricular ejection fraction. The results of ongoing studies in other patient groups such as the ATMOSPHERE trial are awaited.

Published
2013

17. Evaluation of Biventricular Functions With Tissue Doppler Imaging in Patients With Myotonic Dystrophy

Author

Huseyin Oflaz, Beste Ozben, Tolga Ozyigit, Piraye Serdaroglu, Ozyigit, Tolga, Ozben, Beste, Oflaz, Huseyin, and Serdaroglu, Piraye

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Systole, Heart Ventricles, VENTRICULAR DIASTOLIC FUNCTION, Clinical Investigations, Diastole, CTG REPEAT, Myotonic dystrophy, Doppler imaging, MYOCARDIAL PERFORMANCE, Internal medicine, medicine, Health Status Indicators, Humans, Myotonic Dystrophy, cardiovascular diseases, Muscle, Skeletal, INDEX, Ejection fraction, business.industry, Myocardial Perfusion Imaging, Ultrasonography, Doppler, General Medicine, CARDIAC INVOLVEMENT, VELOCITY, medicine.disease, Myotonia, Surgery, Echocardiography, Case-Control Studies, Heart failure, CONDUCTION SYSTEM, Circulatory system, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Isovolumic relaxation time
Abstract

Background: Myotonic dystrophy (MD) is characterized by myotonia with dystrophic involvement of the muscles. Cardiac involvement is usually not evident in the early stages of MD. Hypothesis: We investigated biventricular functions by tissue Doppler imaging (TDI) in MD patients with no overt cardiac involvement to explore the value of TDI in the early detection of myocardial dysfunction. Methods: A total of 21 MD patients (15 male, age: 32.2 ± 12.3 yrs) and 21 healthy controls (13 male, age: 32.2 ± 7.8 yrs) were included. In addition to conventional echocardiography, pulsed Doppler and TDI were performed including measurement of myocardial performance index (MPI); peak systolic (Sm) and early (Em) and atrial (Am) diastolic myocardial velocities at the basal mitral and tricuspid annulus. Results: All patients and controls had normal ejection fraction. Transmitral E peak velocity was significantly lower while both deceleration time of E velocity and isovolumic relaxation time were significantly longer in MD patients (P = 0.007, P = 0.001, and P < 0.001, respectively). Sm, Em and Am peak velocities were significantly lower in MD patients in all segments except for Em of the mitral anterior annulus and Am of the tricuspid lateral annulus. Both left and right ventricular MPI were significantly higher in MD patients (P < 0.001 and P = 0.013, respectively). Conclusion: There are changes in myocardial systolic and diastolic functions in MD patients although they have no overt heart failure. Myocardial tissue velocities and MPI are useful in identifying subclinical biventricular involvement in these patients. Copyright © 2010 Wiley Periodicals, Inc.

Published
2010

18. Assessment of early changes in the segmental functions of the left and the right ventricles after biventricular pacing in heart failure: a study with tissue Doppler imaging

Author

Deniz Acar, Ahmet Kaya Bilge, Dilek Hunerel, Beste Ozben, Yilmaz Nisanci, Kamil Adalet, and Tolga Ozyigit

Subjects
Cardiomyopathy, Dilated, Male, medicine.medical_specialty, Pacemaker, Artificial, Heart disease, Systole, medicine.medical_treatment, Heart Ventricles, Diastole, Cardiac resynchronization therapy, Right ventricles, Doppler imaging, Ventricule gauche, Internal medicine, Ventricular Dysfunction, Medicine, Humans, Ventricular function, business.industry, Stroke Volume, Ultrasonography, Doppler, Middle Aged, medicine.disease, Heart failure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Tissue Doppler imaging allows assessment of systolic and diastolic regional ventricular function. The aim of this study was to assess early changes in regional systolic and diastolic functions and differences in transition time to contraction between the ventricles after cardiac resynchronization therapy. Fourteen patients were included, who underwent echocardiography before and 1 month after resynchronization. The difference between transition time to contraction of left and right ventricles decreased to 24.4 ± 10.7 milliseconds from 65.3 ± 18.2 milliseconds after resynchronization therapy ( P = .001). There was a significant relation between the decrease in difference between transition time and increase in ejection fraction (r = 0.80, P = .002). Early or late diastolic myocardial motion increased in 7 segments of left and 2 segments of right ventricles. Systolic myocardial motion increased in 7 segments of left and in all segments of right ventricles. Resynchronization therapy improved systolic and diastolic functions in both ventricles. The difference between transition time to contraction of ventricles might be helpful in estimating optimal resynchronization.

Published
2008

19. Tricuspid endocarditis in an adult patient with Ebstein's anomaly who has a residual pacemaker lead

Author

Ahmet Kaya Bilge, Beste Ozben, Kamil Adalet, Ercüment Yilmaz, and Tolga Ozyigit

Subjects
Tachycardia, Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Pacemaker, Artificial, Heart Valve Diseases, Regurgitation (circulation), Ebstein's anomaly, Internal medicine, medicine, Endocarditis, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Endocardium, Device Removal, Ultrasonography, Native Valve Endocarditis, business.industry, Endocarditis, Bacterial, Middle Aged, Staphylococcal Infections, medicine.disease, Foreign Bodies, Surgery, Ebstein Anomaly, Infective endocarditis, cardiovascular system, Cardiology, Tricuspid Valve, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Atrial flutter
Abstract

Ebstein’s anomaly is defined as an apical displacement of the attachment of the septal tricuspid valve leaflet from the right atrioventricular annulus that exceeded 1.2 cm in length. Patients with Ebstein’s anomaly are known to have a high potential for developing arrhythmia, in the vast majority, of the tachycardia type. Infective endocarditis is characterized by ulcerovegetational lesions that result from the graft of a microorganism, usually bacterial, on the valvuler endocardium (native valve endocarditis) or on a prosthesis (prosthetic valve endocarditis). Ebstein’s anomaly with tricuspid regurgitation is also thought to be a predisposing condition for infective endocarditis. In this case, we report a patient who presented with atrial flutter and infective endocarditis due to residual pacemaker lead and Ebstein’s anomaly.

Published
2004

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