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11 results on '"Toldos-González Ó"'

6. Recomendaciones sobre el diagnóstico e informe anatomopatológico de los tumores neuroendocrinos hipofisarios. Consenso de expertos de la Sociedad Española de Endocrinologia y Nutrición y de la Sociedad Española de Anatomía Patológica

Author

Picó A, Aranda-López I, Sesmilo G, Toldos-González Ó, Japón MA, Luque RM, and Puig-Domingo M

Subjects
Expert recommendations, Pathology, Recomendaciones de expertos, Neuroendocrine tumors, Tumores neuroendocrinos, Anatomía patológica, Immunohistochemistry, Inmunohistoquímica
Abstract

Pituitary neuroendocrine tumors (PitNETs) constitute, together with other tumors of the sellar region, 15-25% of intracranial neoplasms. In 2017, the World Health Organization proposed a new classification of PitNETs. The main innovation with respect to the 2004 classification was the recommendation to include in the immunohistochemical evaluation of PitNETs the determination of the transcription factors of the 3 pituitary cell lineages: Pit-1, Tpit and SF-1. Additionally, other clinicopathological classifications with a predictive capacity of tumor behavior during follow-up were proposed. Given these changes, it is appropriate to adapt the knowledge generated during the last 15 years to the daily practice of the treatment and monitoring of PitNETs at the Centers of Excellence in Pituitary Pathology. This document includes the positioning of the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Society of Pathology (SEAP) on the classification and denomination of the PitNETs and the information that the pathologist should provide to the clinician to facilitate the treatment and monitoring of these tumors.

Published
2021

9. Monoclonal gammopathy of renal significance: An atypical presentation of Waldenström's disease.

Author

Rodríguez-Doyágüez P, Motornaya-Morozova, Martínez-Miguel P, Castillo-Torres C, Toldos-González Ó, and Gil-Fernández JJ

Abstract

Waldenström's disease is a rare lymphoproliferative syndrome in the bone marrow and sometimes in lymphoid organs which secretes high amounts of monoclonal immunoglobulin M into serum. It can remain indolent for years and rarely affects the kidney, with intraglomerular rather than intratubular damage being predominant, in contrast to multiple myeloma. Different studies identified AL amyloidosis as the most frequent renal lesion, followed by cryoglobulinemic glomerulonephritis. Signs and symptoms may be unspecific, as well as renal manifestations, so collaboration between nephrologists, hematologists, and pathologists is crucial to establish the role of paraprotein in the development of renal damage. We present an atypical case of Waldenström's disease that had a minimal monoclonal peak and clinically debuted with nephritic and nephrotic syndromes. The diagnosis was cryoglobulinemic glomerulonephritis. Currently, there are numerous treatment options, without enough evidence yet to establish a standardised treatment., Competing Interests: The authors declare no conflict of interest. Figure 1.Optical microscopy: glomeruli with nodular pattern, with massive eosinophilic deposits in capillaries. The areas without deposits showed increased cellularity and mesangial matrix, with polymorphonuclear leukocytes and monocytes, and focal images of double contours.Figure 2.Electron microscopy: fibrillar material with microtubular foci in the intracapillary and subendothelial region, compatible with cryoglobulin deposits. Table 1.Evolution just after initiation of treatment, with normalization of renal function and disappearance of nephrotic and nephritic syndrome. 11/08/202112/07/202101/05/202201/26/202203/10/202206/15/2022Hemoglobin (g/dL)10.510.310.412.5Creatinine (g/dL)1.591.551.211.261.280.86Estimated glomerular filtration rate (CKD-EPI, mL/min/1.73 m2)38.1339.3353.0550.0349.5680.16Proteinuria (g/24h)6,8282,9933,7422,156248254Urine red blood cells (red blood cells per high power field)30 – 5030 – 5030 – 5020 – 301 – 51 – 3IgM peak (g/dL)0.580.490.320.350.410.4κ free chains (mg/L)22.520.9720.4525.2626.7418.17λ free chains (mg/L))16.9218.4516.2818.218.1113.28κ/λ ratio1.331.131.261.391.481.37, (© Dustri-Verlag Dr. K. Feistle.)

Published
2024
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10. [Recommendations on the pathological report of pituitary tumors. A consensus of experts of the Spanish Society of Endocrinology and Nutrition and the Spanish Society of Pathology].

Author

Picó A, Aranda-López I, Sesmilo G, Toldos-González Ó, Japón MA, Luque RM, and Puig-Domingo M

Subjects
Consensus, Humans, Pituitary Gland, World Health Organization, Neuroendocrine Tumors, Pituitary Neoplasms
Abstract

Pituitary neuroendocrine tumors (PitNETs) constitute, together with other tumors of the sellar region, 15-25% of intracranial neoplasms. In 2017, the World Health Organization proposed a new classification of PitNETs. The main innovation with respect to the 2004 classification was the recommendation to include in the immunohistochemical evaluation of PitNETs the determination of the transcription factors of the 3 pituitary cell lineages: Pit-1, Tpit and SF-1. Additionally, other clinicopathological classifications with a predictive capacity of tumor behavior during follow-up were proposed. Given these changes, it is appropriate to adapt the knowledge generated during the last 15 years to the daily practice of the treatment and monitoring of PitNETs at the Centers of Excellence in Pituitary Pathology. This document includes the positioning of the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Society of Pathology (SEAP) on the classification and denomination of the PitNETs and the information that the pathologist should provide to the clinician to facilitate the treatment and monitoring of these tumors., (Copyright © 2021 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2021
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11. A Preterm Newborn With the "Barrel Syndrome".

Author

Muñoz Amat B, Vázquez Román S, Gallego Herrero C, Núñez-Enamorado N, Toldos González Ó, and Pallás Alonso CR

Subjects
Autopsy, Basal Ganglia pathology, Cerebellum pathology, Epilepsy etiology, Humans, Infant, Newborn, Male, Meningitis diagnosis, Premature Birth diagnostic imaging, Brain Diseases complications, Brain Diseases diagnosis, Meningitis etiology, Premature Birth physiopathology
Published
2017
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