171 results on '"Toldo I"'
Search Results
2. Primary Stabbing Headache in Children and Adolescents
- Author
-
Reimers, M., primary, Bonemazzi, I., additional, Brunello, F., additional, Cavaliere, E., additional, Sartori, S., additional, and Toldo, I., additional
- Published
- 2024
- Full Text
- View/download PDF
3. Sleep disorders and neuropsychiatric disorders in a pediatric sample of tuberous sclerosis complex: a questionnaire-based study
- Author
-
Moavero, R., primary, Voci, A., additional, La Briola, F., additional, Matricardi, S., additional, Toldo, I., additional, Mancardi, M., additional, Negrin, S., additional, Vigevano, F., additional, Mazzone, L., additional, Valeriani, M., additional, Curatolo, P., additional, and Bruni, O., additional
- Published
- 2022
- Full Text
- View/download PDF
4. Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication
- Author
-
Verrotti, A., Laino, D., Rinaldi, V. E., Suppiej, A., Giordano, L., Toldo, I., Margari, L., Parisi, P., Rizzo, R., Matricardi, S., Cusmai, R., Grosso, S., Gaggero, R., Zamponi, N., Pavone, P., Capovilla, G., Rauchenzauner, M., Cerminara, C., Di Gennaro, G., Esposito, M., Striano, P., Savasta, S., Coppola, G., Siliquini, S., Operto, F., Belcastro, V., Ragona, F., Marseglia, G. L., and Spalice, A.
- Published
- 2016
- Full Text
- View/download PDF
5. Relapse risk factors in anti-N-methyl-D-aspartate receptor encephalitis
- Author
-
Nosadini, Margherita, Granata, Tiziana, Matricardi, Sara, Freri, Elena, Ragona, Francesca, Papetti, Laura, Suppiej, Agnese, Valeriani, Massimiliano, Sartori, Stefano, Italian Working Group on Paediatric Anti-N-methyl-D-aspartate Receptor Encephalitis, Bonuccelli, A, Beccaria, F, Buechner, S, Buratti, S, Cantalupo, G, Cappellari, A, Casellato, S, Cesaroni, E, Cimaz, R, Cordelli, Dm, Costa, P, Dell'Avvento, S, Dilena, R, Falsaperla, R, Foiadelli, T, Frigo, Ac, Fusco, L, Giacobbe, A, Giannotta, M, Grazian, L, Maggio, Mc, Mancardi, Mm, Melis, M, Natali Sora MG, Orsini, A, Petruzzellis, A, Pini, A, Pruna, D, Santangelo, G, Savasta, S, Scaduto, Mc, Serino, D, Simula, D, Solazzi, R, Sotgiu, S, Splendiani, A, Toldo, I, Vigevano, F, Viri, M, Visconti, P, Zamponi, N, Zanus, C, Zoccarato, M, Zuliani, L, Nosadini M., Granata T., Matricardi S., Freri E., Ragona F., Papetti L., Suppiej A., Valeriani M., Sartori S., Bonuccelli A., Beccaria F., Buechner S., Buratti S., Cantalupo G., Cappellari A., Casellato S., Cesaroni E., Cimaz R., Cordelli D.M., Costa P., Dell'Avvento S., Dilena R., Falsaperla R., Foiadelli T., Frigo A.C., Fusco L., Giacobbe A., Giannotta M., Grazian L., Maggio M.C., Mancardi M.M., Melis M., Natali Sora M.G., Orsini A., Petruzzellis A., Pini A., Pruna D., Santangelo G., Savasta S., Scaduto M.C., Serino D., Simula D., Solazzi R., Sotgiu S., Splendiani A., Toldo I., Vigevano F., Viri M., Visconti P., Zamponi N., Zanus C., Zoccarato M., and Zuliani L.
- Subjects
Male ,030506 rehabilitation ,Gastroenterology ,Cohort Studies ,0302 clinical medicine ,Retrospective Studie ,Modified Rankin Scale ,Recurrence ,Risk Factors ,Child ,relapse ,Anti-N-Methyl-D-Aspartate Receptor Encephalitis ,Hazard ratio ,Italy ,Child, Preschool ,Cohort ,anti‐N‐methyl‐D‐aspartate receptor encephalitis ,Female ,0305 other medical science ,Encephalitis ,Human ,Cohort study ,medicine.medical_specialty ,Adolescent ,Socio-culturale ,anti-NMDAR antibodies ,03 medical and health sciences ,anti-NMDAR ,Developmental Neuroscience ,Internal medicine ,medicine ,Humans ,Infant ,Retrospective Studies ,Preschool ,Survival analysis ,Autoimmune encephalitis ,business.industry ,Retrospective cohort study ,medicine.disease ,anti-NMDAR antibodies, autoimmune encephalitis, anti‐N‐methyl‐D‐aspartate receptor encephalitis ,autoimmune encephalitis ,Anti-N-methyl-D-aspartate receptor encephalitis, anti-NMDAR, autoimmune encephalitis, relapse ,Anti-N-Methyl-D-Aspartate Receptor Encephaliti ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Cohort Studie ,business ,030217 neurology & neurosurgery - Abstract
Aim: To identify factors that may predict and affect the risk of relapse in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Method: This was a retrospective study of an Italian cohort of patients with paediatric (≤18y) onset anti-NMDAR encephalitis. Results: Of the 62 children included (39 females; median age at onset 9y 10mo, range 1y 2mo–18y; onset between 2005 and 2018), 21 per cent relapsed (median two total events per relapsing patient, range 2–4). Time to first relapse was median 31.5months (range 7–89mo). Severity at first relapse was lower than onset (median modified Rankin Scale [mRS] 3, range 2–4, vs median mRS 5, range 3–5; admission to intensive care unit: 0/10 vs 3/10). At the survival analysis, the risk of relapsing was significantly lower in patients who received three or more different immune therapies at first disease event (hazard ratio 0.208, 95% confidence interval 0.046–0.941; p=0.042). Neurological outcome at follow-up did not differ significantly between patients with relapsing and monophasic disease (mRS 0–1 in 39/49 vs 12/13; p=0.431), although follow-up duration was significantly longer in relapsing (median 84mo, range 14–137mo) than in monophasic patients (median 32mo, range 4–108mo; p=0.002). Interpretation: Relapses may occur in about one-fifth of children with anti-NMDAR encephalitis, are generally milder than at onset, and may span over a long period, although they do not seem to be associated with severity in the acute phase or with outcome at follow-up. Aggressive immune therapy at onset may reduce risk of relapse. What this paper adds: Relapses of anti-N-methyl-D-aspartate receptor encephalitis may span over a long period. Relapses were not associated with severity in the acute phase or outcome at follow-up. Aggressive immune therapy at onset appears to decrease risk of relapse.
- Published
- 2019
6. Corrigendum: The new Italian registry of infantile thrombosis (RITI): a reflection on its journey, challenges and pitfalls
- Author
-
Maria Federica Pelizza, Matteo Martinato, Anna Rosati, Margherita Nosadini, Paola Saracco, Paola Giordano, Matteo Luciani, Laura Ilardi, Donatella Lasagni, Angelo Claudio Molinari, Rossana Bagna, Antonella Palmieri, Luca Antonio Ramenghi, Massimo Grassi, Mariella Magarotto, Federica Magnetti, Andrea Francavilla, Giuseppe Indolfi, Agnese Suppiej, Chiara Gentilomo, Roberta Restelli, Antonella Tufano, Daniela Tormene, Jacopo Norberto Pin, Clarissa Tona, Davide Meneghesso, Lidia Rota, Marta Conti, Giovanna Russo, Giulia Lorenzoni, Dario Gregori, Stefano Sartori, Paolo Simioni, Collaborators of the R.I.T.I. (Italian and Registry of Infantile Thrombosis), Accorsi Patrizia, Aceto Gabriella, Agnoletti Gabriella, Agostini Manuela, Alfarano Angela, Altieri Elena, Amador Carolina, Antonelli Camilla, Arena Vittoria, Asta Francesca, Baggio Laura, Ballardini Elisa, Baracetti Margherita, Baraldi Eugenio, Barberis Laura, Barisone Elena, Basso Anne Letizia, Battajon Nadia, Bersani Iliana, Biddeci Giada, Biffanti Roberta, Bonardi Claudia Maria, Bonaudo Roberto, Boniver Clementina, Boscarol Gianluca, Bottino Roberto, Bravar Giulia, Brizzi Ilaria, Brolatti Noemi, Braguglia Annabella, Guaragni Brunetta, Bugin Samuela, Calvo Pier Luigi, Capasso Antonella, Capodiferro Donatella, Cappelleri Alessia, Cascarano Maria Teresa, Casellato Susanna, Casini Tommaso, Catarzi Serena, Cavaliere Elena, Cavicchiolo Maria Elena, Celestino Silvia, Celle Maria Elena, Centonze Nicola, Cerutti Alessia, Chakrokh Roksana, Offer Chiara, Chiodin Elisabetta, Chirico Gaetano, Chukhlantseva Natalia, Cifarelli Paola, Cinelli Giulia, Coinu Marisa, Colonna Clara, Comito Donatella, Corato Alessandra, Cordelli Duccio Maria, Crichiutti Giovanni, Cursio Ida, Dagri Arianna, De Maria Beatrice, Del Borrello Giovanni, Di Rienzo Francesca, Doglioni Nicoletta, Dolcemascolo Valentina, Dotta Andrea, Drigo Paola, Drimaco Pietro, Ellero Serena, Falcone Alessandra, Fantauzzi Ambra, Farinasso Daniela, Ferilli Michela, Festa Silvia, Fischer Maximilian, Foiadelli Thomas, Fotzi Ilaria, Francavilla Rosa, Freschi Paola, Gaffuri Marcella, Gallo Elena, Gamalero Lisa, Gandioli Claudia, Garuccio Sergio, Gentile Diletta, Ghionzoli Marco, Giliberti Paola, Greco Filippo, Guariento Chiara, Guidotti Isotta, Iodice Alessandro, Janes Augusta, Laghi Elena, Lampugnani Elisabetta, Lassandro Giuseppe, Laverda Anna Maria, Lazzerotti Alessandra, Lo Tartaro Meragliotta Patrizia, Lombardini Martina, Lorenzon Eleonora, Mainini Nicoletta, Massoud Michela, Materia Valeria, Mattera Raffaele, Mauro Isabella, Melani Federico, Meli Mariaclaudia, Messina Giovanni, Monticone Sonia, Moras Marzia, Negro Ilaria, Olzai Giorgio, Pancani Simone, Pandolfi Maria, Passariello Annalisa, Passarini Alice, Passone Eva, Pastorino Myriam, Pegoraro Veronica, Pennoni Serena, Perilongo Giorgio, Pozzessere Anna, Pruna Dario, Pusiol Anna, Putti Maria Caterina, Rabbone Ivana, Radicioni Maurizio, Renna Salvatore, Ricci Maria Luisa, Rimini Alessandro, Rivellini Sara, Rustioni Gianluca, Salvadori Sabrina, Santoiemma Valentina, Santoro Nicola, Schiavulli Michele, Sebellin Sofia, Sesta Michela, Soffiati Massimo, Sorbo Monica, Spanedda Giuseppina, Stangalini Valeria, Stasolla Salvatore, Tanzi Giorgia, Testa Tiziana, Teutonico Federica, Timpani Giuseppina, Toldo Irene, Trapani Sandra, Vaccari Roberto, Vecchi Marilena, Vento Giovanni, Veraldi Daniele, Villa Giovanna, Visintin Gianluca, Zambelloni Cesare, and Zellini Francesco
- Subjects
thrombosis ,stroke ,children ,pediatric ,registry ,thromboembolism ,Pediatrics ,RJ1-570 - Published
- 2024
- Full Text
- View/download PDF
7. NEW OBSERVATIONAL AND CLINICAL METHODS IN THE TREATMENT OF DEVELOPMENTAL AGE PSYCHOPATHOLOGY
- Author
-
Gatta, M., Miscioscia, M., Svanellini, L., Sisti, M., Sudati, L., Comis, I., Toldo, I., Battistella, P. A., and Simonelli, A.
- Published
- 2018
8. Manuale di neuropsichiatria infantile e dell'adolescenza
- Author
-
Battistella, P. A., Toldo, I., De Carlo, D., Sartori, S., and Gatta, M.
- Published
- 2018
9. Pyridoxine-dependent epilepsies: an observational study on clinical, diagnostic, therapeutic and prognostic features in a pediatric cohort
- Author
-
Falsaperla, R, Vari, Ms, Toldo, I, Murgia, A, Sartori, S, Vecchi, M, Suppiej, A, Burlina, A, Mastrangelo, M, Leuzzi, V, Marchiani, V, De Liso, P, Capovilla, G, Striano, P, Vitaliti, G, and Italian Society of Pediatric Neurology (SINP: Società Italiana di Neurologia, Pediatrica).
- Subjects
Male ,medicine.medical_specialty ,Pediatrics ,Neurology ,Adolescent ,medicine.medical_treatment ,Cohort ,Dependent epilepsies ,Diagnosis ,Observational study ,Pediatric age ,Pyridoxine ,Treatment ,Anticonvulsants ,Child ,Child, Preschool ,Cohort Studies ,Epilepsy ,Female ,Humans ,Infant ,Retrospective Studies ,Seizures ,Vitamin B Complex ,Biochemistry ,NO ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Pathognomonic ,030225 pediatrics ,Medicine ,Preschool ,Adverse effect ,business.industry ,Retrospective cohort study ,Anticonvulsant ,pyridoxine ,dependent epilepsies ,diagnosis ,treatment ,pediatric age ,observational study ,cohort ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The aim of our study was to describe the clinical, electroencephalogram, molecular findings and the diagnostic and therapeutic flow-chart of children with pyridoxine-dependent epilepsies (PDEs). We performed a retrospective observational study on children with PDEs, diagnosed and followed-up in Italian Pediatric Departments. In each centre, the authors collected data from a cohort of children admitted for intractable seizures, responsive to pyridoxine administration and resistant to other anticonvulsant therapies. Data were retrospectively analysed from January 2016 to January 2017. Sixteen patients (13 males, and 3 females) were included. We found that 93.75% of patients underwent conventional anticonvulsant therapy before starting pyridoxine administration and 62.5% had ex-juvantibus diagnosis, as specific serum diagnostic tests had been performed in only 37.5% of patients by alpha-AASA and pipecolic acid blood and urine dosage. The most common type of seizure was generalized tonic-clonic in 7 patients and the most common EEG pattern was characterized by a "burst suppression" pattern. Before pyridoxine administration, other anticonvulsant drugs were used in 93.75% of patients, with consequent onset of drug-resistance. Phenobarbital was the most frequently used drug as first-line treatment. The importance of our study relies on the need of a deeper knowledge of PDEs in terms of early diagnosis, avoiding incorrect treatment and related adverse events, clinical and EEG pathognomonic features, and genetic aspects of the disease.
- Published
- 2017
10. Neuroimaging Changes in Menkes Disease, Part 1
- Author
-
Manara, R, D'Agata, L, Rocco, Mc, Cusmai, R, Freri, E, Pinelli, L, Darra, Francesca, Procopio, E, Mardari, R, Zanus, C, Di Rosa, G, Soddu, C, Severino, M, Ermani, M, Longo, D, Sartori, S, Menkes Working Group in the Italian Neuroimaging Network for Rare Diseases: Toldo, I, Peruzzi, C, Vittorini, R, Spalice, A, Fusco, C, Nosadini, M, Farina, L, Stecco, A, Polonara, G, Donati, Ma, Giordano, L, Dionisi Vici, C, Martinelli, D, Tocchet, A, Fariello, G, Nicita, F, Frattini, D, Martelli, P, Cantalupo, Gaetano, and Zennaro, F.
- Subjects
Menkes disease, neuroimaging, MRI ,Male ,Pathology ,medicine.medical_specialty ,vascular abnormalities ,Neuroimaging ,Disease ,Pediatrics ,030218 nuclear medicine & medical imaging ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Menkes Kinky Hair Syndrome ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,Retrospective cohort study ,Menkes disease ,medicine.disease ,White matter changes ,Magnetic Resonance Imaging ,White Matter ,X-linked disorder ,myelination delay ,medicine.anatomical_structure ,myelination delay, vascular abnormalities, X-linked disorder, copper metabolism ,Disease Progression ,Female ,copper metabolism ,Neurology (clinical) ,business ,Neuroscience ,030217 neurology & neurosurgery ,MRI - Abstract
Menkes disease is a rare multisystem X-linked disorder of copper metabolism. Despite an early, severe, and progressive neurologic involvement, our knowledge of brain involvement remains unsatisfactory. The first part of this retrospective and review MR imaging study aims to define the frequency rate, timing, imaging features, and evolution of intracranial vascular and white matter changes. According to our analysis, striking but also poorly evolutive vascular abnormalities characterize the very early phases of disease. After the first months, myelination delay becomes evident, often in association with protean focal white matter lesions, some of which reveal an age-specific brain vulnerability. In later phases of the disease, concomitant progressive neurodegeneration might hinder the myelination progression. The currently enriched knowledge of neuroradiologic finding evolution provides valuable clues for early diagnosis, identifies possible MR imaging biomarkers of new treatment efficacy, and improves our comprehension of possible mechanisms of brain injury in Menkes disease.
- Published
- 2017
11. Neuroimaging Changes in Menkes Disease, Part 2
- Author
-
Manara, R, Rocco, M C, D'Agata, L, Cusmai, R, Freri, E, Giordano, L, Darra, F, Procopio, E, Toldo, I, Peruzzi, C, Vittorini, R, Spalice, A, Fusco, C, Nosadini, M, Longo, D, Sartori, S, Menkes Working Group in the Italian Neuroimaging Network for Rare Diseases, Mardari, R, Zanus, C, Di Rosa, G, Soddu, C, Severino, M, Ermani, M, Farina, L, Stecco, A, Polonara, G, Donati, Ma, Pinelli, L, Dionisi-Vici, C, Martinelli, D, Tocchet, A, Fariello, G, Nicita, F, Frattini, D, Martelli, P, Cantalupo, G, and Zennara, F
- Subjects
Child abuse ,Male ,Pathology ,medicine.medical_specialty ,Neuroimaging ,Disease ,Pediatrics ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,gray matter changes, X-linked disorder, copper metabolism, neurodegeneration, basal ganglia lesions, subdural collections ,Basal ganglia ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Gray Matter ,Child ,Menkes Kinky Hair Syndrome ,Retrospective Studies ,gray matter changes ,medicine.diagnostic_test ,business.industry ,neurodegeneration ,Brain ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,basal ganglia lesions ,subdural collections ,X-linked disorder ,Menkes disease ,Neurology (clinical) ,copper metabolism ,Differential diagnosis ,business ,030217 neurology & neurosurgery ,Rare disease - Abstract
This is the second part of a retrospective and review MR imaging study aiming to define the frequency rate, timing, imaging features, and evolution of gray matter changes in Menkes disease, a rare multisystem X-linked disorder of copper metabolism characterized by early, severe, and progressive neurologic involvement. According to our analysis, neurodegenerative changes and focal basal ganglia lesions already appear in the early phases of the disease. Subdural collections are less common than generally thought; however, their presence remains important because they might challenge the differential diagnosis with child abuse and might precipitate the clinical deterioration. Anecdotal findings in our large sample seem to provide interesting clues about the protean mechanisms of brain injury in this rare disease and further highlight the broad spectrum of MR imaging findings that might be expected while imaging a child with the suspicion of or a known diagnosis of Menkes disease.
- Published
- 2017
12. Nutraceuticals and herbs in the treatment of pediatric primary headaches in 11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches : Rome, Italy. 01-03 December 2017
- Author
-
Piretti, E, Toldo, I, Rossaro, Mp, Sartori, S, Gatta, M, Nosadini, M, and Battistella, Pa
- Subjects
TENSION-TYPE ,DOUBLE-BLIND ,MELATONIN ,HEADACHE ,MIGRAINE ,MAGNESIUM ,CHILDREN ,COENZYME Q10 ,PREVENTION ,PROPHYLAXIS ,TENSION-TYPE, HEADACHE, DOUBLE-BLIND, DOSE RIBOFLAVIN, MIGRAINE, PROPHYLAXIS, CHILDREN,COENZYME Q10, PREVENTION, MELATONIN, MAGNESIUM ,DOSE RIBOFLAVIN - Published
- 2017
13. Erratum to: Oculo-auriculo-vertebral spectrum: going beyond the first and second pharyngeal arch involvement (Neuroradiology, (2017), 59, 3, (305-316), 10.1007/s00234-017-1795-1)
- Author
-
Brotto, D., Manara, R., Ghiselli, S., Lovo, E., Mardari, R., Toldo, I., Castiglione, A., Schifano, G., Stritoni, V., Bovo, R., Trevisi, P., and Martini, A.
- Published
- 2017
14. Headache and recurrent abdominal pains in preschool children
- Author
-
Battistella, P. A. and Toldo, I.
- Published
- 2006
- Full Text
- View/download PDF
15. Long-term outcome of epilepsy in patients with prader–willi syndrome
- Author
-
Verrotti A, Cusmai R, Laino D, CAROTENUTO, Marco, ESPOSITO, Maria, Falsaperla R, Margari L, Rizzo R, Savasta S, Grosso S, Striano P, Belacastro V, Franzoni E, Curatolo P, Giordano L, Freri E, Matricardi S, Pruna D, Toldo I, Tozzi E, Lobefalo L, Operto F, Altobelli E, Chiarelli F, Spalice A., Verrotti, A, Cusmai, R, Laino, D, Carotenuto, Marco, Esposito, Maria, Falsaperla, R, Margari, L, Rizzo, R, Savasta, S, Grosso, S, Striano, P, Belacastro, V, Franzoni, E, Curatolo, P, Giordano, L, Freri, E, Matricardi, S, Pruna, D, Toldo, I, Tozzi, E, Lobefalo, L, Operto, F, Altobelli, E, Chiarelli, F, and Spalice, A.
- Subjects
Epilepsy ,Prader–Willi syndrome ,EEG ,Long term outcome - Abstract
Prader-Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader-Willi syndrome patients suffering from epilepsy. We retrospectively studied 38 patients with Prader-Willi syndrome and seizures. Results of neuroimaging studies were obtained for 35 individuals. We subdivided these patients into two groups: group A, 24 patients, without brain lesions; and group B, 11 patients, with brain abnormalities. All patients were re-evaluated after a period of at least 10 years. Twenty-one patients (55.2 %) were affected by generalized epilepsy and 17 patients (44.8 %) presented focal epilepsy. The most common seizure type was generalized tonic-clonic seizure. The mean age at seizure onset was 4.5 years (ranged from 1 month to 14 years). In the follow-up period, seizure freedom was achieved in 32 patients (84.2 %). Seizure freedom was associated with electroencephalographic normalization, while the six children presenting drug-resistant epilepsy showed persistence of electroencephalographic abnormalities. Group B patients showed a higher prevalence of drug-resistant epilepsy. Patients with Prader-Willi syndrome were frequently affected by generalized seizures. Most of the patients had a favorable evolution, although, patients with brain abnormalities presented a worse outcome, suggesting that the presence of these lesions can influence the response to antiepileptic therapy. Prader–Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader–Willi syndrome patients suffering from epilepsy. We retrospectively studied 38 patients with Prader–Willi syndrome and seizures. Results of neuroimaging studies were obtained for 35 individuals. We subdivided these patients into two groups: group A, 24 patients, without brain lesions; and group B, 11 patients, with brain abnormalities. All patients were re-evaluated after a period of at least 10 years. Twenty-one patients (55.2 %) were affected by generalized epilepsy and 17 patients (44.8 %) presented focal epilepsy. The most common seizure type was generalized tonic– clonic seizure. The mean age at seizure onset was 4.5 years (ranged from 1 month to 14 years). In the follow-up period, seizure freedom was achieved in 32 patients (84.2 %). Seizure freedom was associated with electroencephalographic normalization, while the six children presenting drug-resistant epilepsy showed persistence of electroencephalographic abnormalities. Group B patients showed a higher prevalence of drug-resistant epilepsy. Patients with Prader–Willi syndrome were frequently affected by generalized seizures. Most of the patients had a favorable evolution, although, patients with brain abnormalities presented a worse outcome, suggesting that the presence of these lesions can influence the response to antiepileptic therapy.
- Published
- 2015
16. Clinical guidelines in pediatric headache: evaluation of quality using the AGREE II instrument
- Author
-
Parisi, P, Vanacore, N, Belcastro, V, Carotenuto, M, Giudice, Ed, Mariani, R, Papetti, L, Pavone, P, Savasta, S, Striano, P, Toldo, I, Tozzi, Elisabetta, Verrotti, A, Raucci, U, 'Pediatric Headache Commission' of Società Italiana di Neurologia, P. e. d. i. a. t. r. i. c. a., VERROTTI di PIANELLA, Alberto, Parisi, P, Vanacore, N, Belcastro, V, Carotenuto, Marco, Del Giudice, E, Mariani, R, Papetti, L, Pavone, P, Savasta, S, Striano, P, Toldo, I, Tozzi, E, Verrotti, A, Raucci, U., Carotenuto, M, and DEL GIUDICE, Ennio
- Subjects
medicine.medical_specialty ,media_common.quotation_subject ,Clinical Neurology ,Nice ,Agree II instrument ,Children ,Guidelines ,Pediatric headache ,Quality of guidelines ,Child ,Evidence-Based Medicine ,Headache ,Humans ,Pediatrics ,Practice Guidelines as Topic ,Quality of Health Care ,State Medicine ,Anesthesiology and Pain Medicine ,Neurology (clinical) ,Medicine (all) ,Cephalalgia ,medicine ,Quality (business) ,Pediatricagree II instrument ,Psychiatry ,National Guideline Clearinghouse ,book ,media_common ,computer.programming_language ,book.periodical ,guidelines ,pediatric headache ,quality of guidelines ,child ,evidence-based medicine ,headache ,humans ,childrens ,practice guidelines as topic ,quality of health care ,state medicine ,neurology (clinical) ,anesthesiology and pain medicine ,business.industry ,General Medicine ,Evidence-based medicine ,Guideline ,Quality Score ,Inclusion and exclusion criteria ,Physical therapy ,business ,computer ,Research Article - Abstract
Background The Appraisal of Guidelines for Research and Evaluation (AGREE II) tool is a validated questionnaire used to assess the methodological quality of clinical guidelines (CGs). We used the AGREE II tool to assess the development process, the methodological quality, and the quality of reporting of available pediatric CGs for the management of headache in children. We also studied the variability in responses related to the characteristics of eleven Italian neuropediatric centers, showing similarities and differences in the main recommendations reported in CGs. Methods A systematic literature search was conducted from January 2002 to June 2013 on Mediline, the Cochrane database, the National Guideline Clearinghouse website and the NHS evidence search tool, using the following terms: headache, cephalalgia, guidelines and children (MESH or text words). Six CGs providing information on the diagnosis and management of headache and specific recommendations for children were selected. Eleven neuropediatric centers assessed the overall quality and the appropriateness of all available CGs using of the AGREE II instrument. Results Six CGs meeting the inclusion and exclusion criteria were identified and assessed by 11 reviewers. Our study showed that the NICE CGs was “strongly recommended” while the French and Danish CGs were mainly “not recommended”. The comparison between the overall quality score of the French CGs and the NICE CGs was statistically significant (6.54 ± 0.69 vs 4.18 ± 1.08; p =0.001). The correlation analysis between quality domain score and guideline publication date showed a statistically significant association only for the “editorial independence” domain (r = 0.842 p = 0.035). The intra-class coefficients showed that the 11 reviewers had the highest agreement for the Lewis CGs (r = 0.857), and the lowest one for the NICE CGs (r = 0.656). Statistical analyses showed that professionals from outpatient services dedicated pediatric headache assigned a higher overall quality score to the NICE CGs as compared to professionals from non-outpatient services (6.86 ± 0.38 vs 6.0 ± 0.82; p = 0.038). Conclusions CGs resulted definitely of low-moderate quality and non “homogeneous”. Further major efforts are needed to update the existing CGs according to the principles of evidence based medicine.
- Published
- 2014
17. Pediatric moyamoya disease and syndrome in Italy: Data from the Italian Society of Pediatric Neurology multicentric retrospective study
- Author
-
Sartori, S., primary, Po', C., additional, Carai, A., additional, Rosati, A., additional, Accorsi, P., additional, Iodice, A., additional, Savasta, S., additional, D'Avella, D., additional, Greco, F., additional, Raviglione, F., additional, Ragazzi, P., additional, Agostini, M., additional, Cesaroni, E., additional, Di Rosa, G., additional, Striano, P., additional, Nicita, F., additional, Cordelli, D., additional, Suppiej, A., additional, Nosadini, M., additional, Marras, C.E., additional, and Toldo, I., additional
- Published
- 2017
- Full Text
- View/download PDF
18. Neuroimaging Changes in Menkes Disease, Part 2
- Author
-
Manara, R., primary, Rocco, M.C., additional, D'agata, L., additional, Cusmai, R., additional, Freri, E., additional, Giordano, L., additional, Darra, F., additional, Procopio, E., additional, Toldo, I., additional, Peruzzi, C., additional, Vittorini, R., additional, Spalice, A., additional, Fusco, C., additional, Nosadini, M., additional, Longo, D., additional, and Sartori, S., additional
- Published
- 2017
- Full Text
- View/download PDF
19. The new Italian registry of infantile thrombosis (RITI): A reflection on its journey, challenges and pitfalls
- Author
-
Maria Federica Pelizza, Matteo Martinato, Anna Rosati, Margherita Nosadini, Paola Saracco, Paola Giordano, Matteo Luciani, Laura Ilardi, Donatella Lasagni, Angelo Claudio Molinari, Rossana Bagna, Antonella Palmieri, Luca Antonio Ramenghi, Massimo Grassi, Mariella Magarotto, Federica Magnetti, Andrea Francavilla, Giuseppe Indolfi, Agnese Suppiej, Chiara Gentilomo, Roberta Restelli, Antonella Tufano, Daniela Tormene, Jacopo Norberto Pin, Clarissa Tona, Davide Meneghesso, Lidia Rota, Marta Conti, Giovanna Russo, Giulia Lorenzoni, Dario Gregori, Stefano Sartori, Paolo Simioni, Collaborators of the R.I.T.I. (Italian Registry of Infantile Thrombosis), Accorsi Patrizia, Aceto Gabriella, Agnoletti Gabriella, Agostini Manuela, Alfarano Angela, Altieri Elena, Amador Carolina, Antonelli Camilla, Arena Vittoria, Asta Francesca, Baggio Laura, Ballardini Elisa, Baracetti Margherita, Baraldi Eugenio, Barberis Laura, Barisone Elena, Basso Anne Letizia, Battajon Nadia, Bersani Iliana, Biddeci Giada, Biffanti Roberta, Bonardi Claudia Maria, Bonaudo Roberto, Boniver Clementina, Boscarol Gianluca, Bottino Roberto, Bravar Giulia, Brizzi Ilaria, Brolatti Noemi, Braguglia Annabella, Guaragni Brunetta, Bugin Samuela, Calvo Pier Luigi, Capasso Antonella, Capodiferro Donatella, Cappelleri Alessia, Cascarano Maria Teresa, Casellato Susanna, Casini Tommaso, Catarzi Serena, Cavaliere Elena, Cavicchiolo Maria Elena, Celestino Silvia, Celle Maria Elena, Centonze Nicola, Cerutti Alessia, Chakrokh Roksana, Offer Chiara, Chiodin Elisabetta, Chirico Gaetano, Chukhlantseva Natalia, Cifarelli Paola, Cinelli Giulia, Coinu Marisa, Colonna Clara, Comito Donatella, Corato Alessandra, Cordelli Duccio Maria, Crichiutti Giovanni, Cursio Ida, Dagri Arianna, De Maria Beatrice, Del Borrello Giovanni, Di Rienzo Francesca, Doglioni Nicoletta, Dolcemascolo Valentina, Dotta Andrea, Drigo Paola, Drimaco Pietro, Ellero Serena, Falcone Alessandra, Fantauzzi Ambra, Farinasso Daniela, Ferilli Michela, Festa Silvia, Fischer Maximilian, Foiadelli Thomas, Fotzi Ilaria, Francavilla Rosa, Freschi Paola, Gaffuri Marcella, Gallo Elena, Gamalero Lisa, Gandioli Claudia, Garuccio Sergio, Gentile Diletta, Ghionzoli Marco, Giliberti Paola, Greco Filippo, Guariento Chiara, Guidotti Isotta, Iodice Alessandro, Janes Augusta, Laghi Elena, Lampugnani Elisabetta, Lassandro Giuseppe, Laverda Anna Maria, Lazzerotti Alessandra, Lo Tartaro Meragliotta Patrizia, Lombardini Martina, Lorenzon Eleonora, Mainini Nicoletta, Massoud Michela, Materia Valeria, Mattera Raffaele, Mauro Isabella, Melani Federico, Meli Mariaclaudia, Messina Giovanni, Monticone Sonia, Moras Marzia, Negro Ilaria, Olzai Giorgio, Pancani Simone, Pandolfi Maria, Passariello Annalisa, Passarini Alice, Passone Eva, Pastorino Myriam, Pegoraro Veronica, Pennoni Serena, Perilongo Giorgio, Pozzessere Anna, Pruna Dario, Pusiol Anna, Putti Maria Caterina, Rabbone Ivana, Radicioni Maurizio, Renna Salvatore, Ricci Maria Luisa, Rimini Alessandro, Rivellini Sara, Rustioni Gianluca, Salvadori Sabrina, Santoiemma Valentina, Santoro Nicola, Schiavulli Michele, Sebellin Sofia, Sesta Michela, Soffiati Massimo, Sorbo Monica, Spanedda Giuseppina, Stangalini Valeria, Stasolla Salvatore, Tanzi Giorgia, Testa Tiziana, Teutonico Federica, Timpani Giuseppina, Toldo Irene, Trapani Sandra, Vaccari Roberto, Vecchi Marilena, Vento Giovanni, Veraldi Daniele, Villa Giovanna, Visintin Gianluca, Zambelloni Cesare, and Zellini Francesco
- Subjects
thrombosis ,stroke ,children ,pediatric ,registry ,thromboembolism ,Pediatrics ,RJ1-570 - Abstract
IntroductionThrombotic events in neonates and children represent a rare although severe occurrence in view of the associated risk of mortality and sequelae. Quality evidence is limited in this field, and registry studies provide an essential base for research. The aim of this paper is to present the new Italian Registry of Infantile Thrombosis (RITI), set it into the scene of international thrombosis and stroke registries, and provide some insight on the challenges associated with registry management.MethodsWe present the detailed structure and content of the new RITI registry, a brief overview of its main data, and a reflection on its features, pitfalls and the main challenges related to its management.ResultsThe RITI, initially started in 2007 and officially re-launched in 2017 after structural modifications, is a non-interventional retrospective and prospective registry study collecting data on neonatal and pediatric patients (0–18 years) who experienced a systemic or cerebral thrombotic event in Italy. The RITI is managed by a multidisciplinary team with expertise in pediatric thrombosis, and participation is open to all Italian physicians, on a voluntary basis. The overall aim of the registry is to acquire new evidence to better characterize the population of children with thrombotic events and improve their management and outcome. 48 Italian pediatric and intensive care units are actively involved in the RITI, including 85 medical doctors from 16 Italian regions. A total of 1,001 neonates and children affected by cerebral or systemic thrombosis have been enrolled.DiscussionThe RITI is one of the largest available European registries of neonatal and pediatric thrombosis. National registries like the RITI represent a model for the study of rare conditions based on multidisciplinary and multicenter collaboration, aimed at overcoming the limitations due to small populations of patients, and creating a network of experts for patient referral and continuous education. Moreover, registry studies have a pivotal role in the research on pediatric thrombosis, due to the limited feasibility of high-quality studies. In our experience, the main critical stages, pitfalls and challenges in registry management include adequate registry designing, diffusion, data completeness and quality control.
- Published
- 2023
- Full Text
- View/download PDF
20. Pharmacological treatment of primary headaches in children: a multicentre Italian study
- Author
-
Toldo I, Rattin M, De Carlo D, Bolzonella B, Perissinotto E, Sartori S, Rossi LN, Vecchio A, Simonati A, Scalas C, Sciruicchio V, Raieli V, Mazzotta G, Balottin U, Tozzi E, Valeriani M, Cianchetti C, Guidetti V, Battistella PA, CAROTENUTO, Marco, Toldo, I, Rattin, M, De Carlo, D, Bolzonella, B, Perissinotto, E, Sartori, S, Rossi, Ln, Vecchio, A, Simonati, A, Carotenuto, Marco, Scalas, C, Sciruicchio, V, Raieli, V, Mazzotta, G, Balottin, U, Tozzi, E, Valeriani, M, Cianchetti, C, Guidetti, V, and Battistella, Pa
- Abstract
Introduction In the literature there are few data about the use of pharmacological treatments (acute and prophylaxis) of primary headaches [migraine (M), tension-type headache (TTH)] in children [1]. Materials and methods Retrospective multicentre study conducted in 13 Juvenile Headache Centres; inclusion criteria: 1) diagnosis of primary headache (ICHD-II 2004); 2) stable headache pattern (>6 months). Results Seven hundred and thirty-two cases (349 m, 383 f), mean age: 12 years. Headache types: M 68%, TTH 21%, M+TTH 5%, other 4%. The statistical analysis, conducted on patients with M or TTH (n=659), considered: efficacy and safety of several drugs, any differences based on age, diagnosis and geographical distribution. Symptomatic treatment: 93% of children (M 95%, TTH 88%); type of drug: paracetamol (M 75%, TTH 75%), NSAIDs (M 51%, TTH 27%), triptans (M 6%, TTH 0%); good-excellent efficacy 72%, good-excellent tolerability 92%. Prophylaxis therapy: 52% of cases (M 45%, TTH 44%); type of drug: flunarizine (M 18%, TTH 2%), pizotifen (M 6%, TTH 0%), amitriptyline (M 3%, TTH 5%), anticonvulsants (M 7%, TTH 1%), supplements (M 31%, TTH 34%), melatonin (M 10%, TTH 10%); good-excellent efficacy 76%, good-excellent tolerability 85%. Discussion and conclusions In our study population M prevails (76%). Symptomatic therapy is frequently used (93%), more often in M than TTH, with good efficacy and tolerability for all drugs; it is ineffective only in 10% of cases (range 7-23%). The use of NSAIDs prevail in M than TTH; few M (6%) use triptans. Prophylaxis therapy, prescribed in about half of cases (both in M and TTH), is ineffective in 12% of cases, but is usually well tolerated; supplements (32%) and flunarizine (14%) prevail.
- Published
- 2013
21. A case of neonatal onset leucoencefalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) with rapid progression
- Author
-
Boscardin, C., Sartori, S., Mardari, R., Talenti, G., Suppiej, A, and Toldo, I.
- Subjects
NO - Published
- 2015
22. Congenital absence of gluteal muscles without spina bifida occulta: the first case report
- Author
-
Vigo, G., Toldo, I., De Grandis, D., Beltrame, V., Sartori, S., and Suppiej, A
- Subjects
Socio-culturale - Published
- 2015
23. Hemiplegic migraine: with onset in childhood:the first multicenter study
- Author
-
Toldo, I., Rattin, M., Pelizza, M. F., Moscano, F., Tozzi, Elisabetta, Verrotti, A., Carotenuto, M., Lisotto, C., Ruffatti, S., Termine, C., Maggioni, F., Battistella, P. A., and S. S. A. R. T. O. R., I.
- Published
- 2015
24. Terapia delle cefalee primarie in età evolutiva: risultati preliminari di uno studio multicentrico italiano
- Author
-
Toldo I, De Carlo D, Bolzonella B, Perissinotto E, Sartori S, Rossi LN, Vecchio A, Limonati A, Scalas C, Sciruicchio V, Raieli V, Mazzotta G, Balottin U, Tozzi E, Guidetti V, Battistella PA, CAROTENUTO, Marco, Toldo, I, De Carlo, D, Bolzonella, B, Perissinotto, E, Sartori, S, Rossi, Ln, Vecchio, A, Limonati, A, Carotenuto, Marco, Scalas, C, Sciruicchio, V, Raieli, V, Mazzotta, G, Balottin, U, Tozzi, E, Guidetti, V, and Battistella, Pa
- Published
- 2011
25. Treatment of primary headaches in children: preliminary results of a multicentre Italian study
- Author
-
Toldo I, De Carlo D, Bolzonella D, Perissinotto E, Sartori S, Rossi LN, Vecchio A, Simonati A, Scalas C, Sciruicchio V, Raieli V, Mazzotta G, Balottin U, Tozzi E, Guidetti V, Battistella PA, CAROTENUTO, Marco, Toldo, I, De Carlo, D, Bolzonella, D, Perissinotto, E, Sartori, S, Rossi, Ln, Vecchio, A, Simonati, A, Carotenuto, Marco, Scalas, C, Sciruicchio, V, Raieli, V, Mazzotta, G, Balottin, U, Tozzi, E, Guidetti, V, and Battistella, Pa
- Abstract
Introduction The are few data in the literature about the use of pharmacological and non-pharmacological therapies for primary headaches (migraine: M; tension-type headache: TTH) in children [1]. Materials and methods A retrospective study was conducted by twelve Juvenile Headache Centres; inclusion criteria: (1) diagnosis of primary headache (ICHD-II, 2004); (2) stable headache pattern ([6 months). Results Three hundred and twenty cases (163 M, 157 F) with mean age at interview of 11.1 ± 3.2 years (1–19 years). Headache types: M 71% (MO 62%, MA 6%, chronic M 3%), TTH 20% (ETTH 17%, CTTH 3%), and M + TTH 7%, other 2%. A) Symptomatic treatment used in 92% of cases (1 drug 57%, 2 drugs 26%, 3 drugs 9%); M 95% versus TTH 82% (p\0.0002); type of drug: paracetamol (P) (M 84%, TTH 73%), NSAIDs (M 46%, TTH 24%), triptans (T) (M 5%, TTH 0%); good–excellent efficacy 53%, good–excellent tolerability 86%. Prescriber: paediatrician (47%), child neuropsychiatry (41%), self-prescription (10%). (B) Prophylaxis therapy used in 46% of cases (1 drug 31%, 2 drugs 11%, 3 drugs 4%); M 53% versus CT 29% (p\0.01); type of drug: flunarizine (M 22% vs. TTH 2%, p\0.0002), pizotifen (M 7%, TTH 0%), propranolol (M 3%, TTH 0%), amitriptyline (M 1%, TTH 2%), anticonvulsants (M 7%, TTH 0%), supplements (M 25%, TTH 19%), melatonin (M 4%, TTH 6%); good–excellent efficacy 65%, good– excellent tolerability 80%. Prescriber: paediatrician (14%), child neuropsychiatrist (84%), no self-prescription. (C) Non-pharmacological treatments (N = 27, 8%): relaxation/biofeedback (30%), cognitive-behavioural therapy (22%), homeopathy (15%), treatment of malocclusion (15%), acupuncture (7%), psychotherapy (7%) and biofeedback (4%). (D) Rating more effective therapy: pharmacological symptomatic (57%) than prophylaxis combined with symptomatic (25%) or alone (16%); better tolerated therapy: pharmacological symptomatic (57%), than prophylaxis combined with symptomatic (22%) or alone (18%). Main expectations of the patient: effect on pain (62%), speed of action (30%) and lack of side effects (21%). Discussion and conclusions The study population consists predominantly of migraineurs (71%). The therapy most widely used was symptomatic (92%), especially P or NSAIDs, with limited use of T (E 5%) with good efficacy and tolerability. The prophylactic drugs most used were supplements (25%) and flunarizine (22%), while AEDs were rarely used (7%). The prophylaxis was ineffective in a third of migraineurs (28–34%), although often well tolerated (43–60%). The non-pharmacological therapy was not widely used (7%) and rarely preferred by patients (2–3%).
- Published
- 2011
26. Headache in pediatric multiple sclerosis: data from Padua case series 2003-2013
- Author
-
Nosadini, M, Sartori, S, Rossato, S, Toldo, I, Pelizza, Mf, De Carlo, D., Bolzonella, B, Perini, P, Gallo, P, Suppiej, A, and Battistella, Pa
- Subjects
Socio-culturale - Published
- 2014
27. BIM AND KNOWLEDGE MANAGEMENT FOR BUILDING HERITAGE
- Author
-
Simeone, D., STEFANO CURSI, Toldo, I., and Carrara, G.
- Subjects
BIM ,built heritage ,ontology-based systems ,knowledge management ,Archaeological investigation - Published
- 2014
28. Psychotherapy and Lausanne Trilogue Play: A Case Report
- Author
-
Gatta, M, primary, Stucchi, M, additional, Svanellini, L, additional, Toldo, I, additional, Difronzo, M, additional, Sudati, L, additional, and Ferruzza, E, additional
- Published
- 2016
- Full Text
- View/download PDF
29. Alliance with patient and collaboration with parents throughout the psychotherapeutic process with children and adolescents: a pilot study
- Author
-
Gatta, M., Andrea Spoto, Svanellini, L., Lai, J., Toldo, I., Testa, C. P., and Battistella, P. A.
- Published
- 2012
30. Terapia delle cefalee primarie in età evolutiva: risultati preliminari di uno studio multicentrico
- Author
-
Toldo, I., Bolzonella, B., De Carlo, D., Sartori, S., Rossi, L., Vecchio, A., Simonati, A., Carotenuto, M., Scalas, C., Raieli, V., Mazzotta, Giovanni, and Battistella, P. A.
- Published
- 2011
31. Treatment of primary headaches in children: Preliminary results of a multicentre Italian Study
- Author
-
Toldo, I., De Carlo, D., Bolzonella, B., Perissinotto, E., Sartori, S., Vecchio, A., Scalas, C., Sciruicchio, V., Raieli, V., Mazzotta, Giovanni, Ballottin, U., Tozzi, E., Guidetti, V., and Battistella, Pa
- Subjects
Pediatric headache - Published
- 2011
32. Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication
- Author
-
Verrotti, A., primary, Laino, D., additional, Rinaldi, V. E., additional, Suppiej, A., additional, Giordano, L., additional, Toldo, I., additional, Margari, L., additional, Parisi, P., additional, Rizzo, R., additional, Matricardi, S., additional, Cusmai, R., additional, Grosso, S., additional, Gaggero, R., additional, Zamponi, N., additional, Pavone, P., additional, Capovilla, G., additional, Rauchenzauner, M., additional, Cerminara, C., additional, Di Gennaro, G., additional, Esposito, M., additional, Striano, P., additional, Savasta, S., additional, Coppola, G., additional, Siliquini, S., additional, Operto, F., additional, Belcastro, V., additional, Ragona, F., additional, Marseglia, G. L., additional, and Spalice, A., additional
- Published
- 2015
- Full Text
- View/download PDF
33. PP13.1 – 2834: Paediatric anti-N-methyl-D-aspartate receptor encephalitis: The first Italian multicenter case series
- Author
-
Sartori, S., primary, Pelizza, M.F., additional, Nosadini, M., additional, Cesaroni, E., additional, Falsaperla, R., additional, Capovilla, G., additional, Mancardi, M.M., additional, Santangelo, G., additional, Cantalupo, G., additional, Cappellari, A., additional, Costa, P., additional, Bernardina, B. Dalla, additional, Dilena, R., additional, Pruna, D., additional, Serino, D., additional, Vanadia, E., additional, Vigevano, F., additional, Zanus, C., additional, Toldo, I., additional, and Suppiej, A., additional
- Published
- 2015
- Full Text
- View/download PDF
34. PP04.12 – 3020: Chromosomal rearrangements of 6p25.3 and Moyamoya syndrome: A non-incidental association
- Author
-
Po, C., primary, Suppiej, A., additional, Causin, F., additional, Talenti, G., additional, D'Avella, D., additional, Sartori, S., additional, and Toldo, I., additional
- Published
- 2015
- Full Text
- View/download PDF
35. P133 – 2909: Hemiplegic migraine with onset in childhood: The first multicenter Italian study
- Author
-
Toldo, I., primary, Rattin, M., additional, Pelizza, M.F., additional, Moscano, F., additional, Tozzi, E., additional, Verrotti, A., additional, Carotenuto, M., additional, Lisotto, C., additional, Ruffatti, S., additional, Termine, C., additional, Maggioni, F., additional, Battistella, P.A., additional, and Sartori, S., additional
- Published
- 2015
- Full Text
- View/download PDF
36. PP05.15 – 2915: A case of neonatal onset leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) with rapid progression
- Author
-
Boscardin, C., primary, Sartori, S., additional, Mardari, R., additional, Suppiej, A., additional, and Toldo, I., additional
- Published
- 2015
- Full Text
- View/download PDF
37. PP09.14 – 2843: Congenital absence of gluteal muscles without spina bifida occulta: The first case report
- Author
-
Vigo, G., primary, Toldo, I., additional, De Grandis, D., additional, Beltrame, V., additional, Sartori, S., additional, and Suppiej, A., additional
- Published
- 2015
- Full Text
- View/download PDF
38. Cranial Nerve Abnormalities in Oculo-Auriculo-Vertebral Spectrum
- Author
-
Manara, R., primary, Brotto, D., additional, Ghiselli, S., additional, Mardari, R., additional, Toldo, I., additional, Schifano, G., additional, Cantone, E., additional, Bovo, R., additional, and Martini, A., additional
- Published
- 2015
- Full Text
- View/download PDF
39. Neuropsychological outcome after paediatric temporal lobe surgery: Analysis of 6 cases [Outcome neuropsicologico del trattamento chirurgico dell'epilessia del lobo temporale in età pediatrica: Analisi di 6 casi]
- Author
-
Stefano Sartori, Cendron, M., Toldo, I., Boniver, C., Mai, R., Lo Russo, G., and Vecchi, M.
- Published
- 2006
40. 114. Movement disorder and EEG patterns in anti-NMDAr antibodies encephalitis
- Author
-
Nosadini, M., primary, Sartori, S., additional, Toldo, I., additional, Cappellari, A., additional, de Palma, L., additional, Cainelli, E., additional, Zuliani, L., additional, Giometto, B., additional, Boniver, C., additional, and Suppiej, A., additional
- Published
- 2013
- Full Text
- View/download PDF
41. The Pitt-Hopkins syndrome: report of 16 new patients and clinical diagnostic criteria
- Author
-
Marangi, Giuseppe, Ricciardi, Stefania, Orteschi, Daniela, Lattante, Serena, Murdolo, Marina, Dallapiccola, B, Biscione, Chiara, Lecce, Rosetta, Chiurazzi, Pietro, Romano, C, Greco, D, Pettinato, R, Sorge, G, Pantaleoni, C, Alfei, E, Toldo, I, Magnani, C, Bonanni, P, Martinez, F, Serra, G, Battaglia, Domenica Immacolata, Lettori, Donatella, Vasco, Gessica, Baroncini, A, Daolio, C, Zollino, Marcella, Marangi, Giuseppe (ORCID:0000-0002-6898-8882), Lattante, Serena (ORCID:0000-0003-2891-0340), Chiurazzi, Pietro (ORCID:0000-0001-5104-1521), Battaglia, Domenica Immacolata (ORCID:0000-0003-0491-4021), Zollino, Marcella (ORCID:0000-0003-4871-9519), Marangi, Giuseppe, Ricciardi, Stefania, Orteschi, Daniela, Lattante, Serena, Murdolo, Marina, Dallapiccola, B, Biscione, Chiara, Lecce, Rosetta, Chiurazzi, Pietro, Romano, C, Greco, D, Pettinato, R, Sorge, G, Pantaleoni, C, Alfei, E, Toldo, I, Magnani, C, Bonanni, P, Martinez, F, Serra, G, Battaglia, Domenica Immacolata, Lettori, Donatella, Vasco, Gessica, Baroncini, A, Daolio, C, Zollino, Marcella, Marangi, Giuseppe (ORCID:0000-0002-6898-8882), Lattante, Serena (ORCID:0000-0003-2891-0340), Chiurazzi, Pietro (ORCID:0000-0001-5104-1521), Battaglia, Domenica Immacolata (ORCID:0000-0003-0491-4021), and Zollino, Marcella (ORCID:0000-0003-4871-9519)
- Abstract
Pitt-Hopkins syndrome (PTHS) is characterized by severe intellectual disability, typical facial gestalt and additional features, such as breathing anomalies. Following the discovery of the causative haploinsufficiency of transcription factor 4 (TCF4), about 60 patients have been reported. We looked for TCF4 mutations in 63 patients with a suspected PTHS. Haploinsufficiency of TCF4 was identified in 14 patients, as a consequence of large 18q21.2 chromosome deletions involving TCF4 (2 patients), gene mutations (11 patients) and a t(14q;18q) balanced translocation disrupting TCF4 (one patient). By evaluating the clinical features of these patients, along with literature data, we noticed that, in addition to the typical facial gestalt, the PTHS phenotype results from the various combinations of the following characteristics: intellectual disability with severe speech impairment, normal growth parameters at birth, postnatal microcephaly, breathing anomalies, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities. Although PTHS is currently considered to be involved in differential diagnosis with Angelman and Rett syndromes, we found that combining the facial characteristics with a detailed analysis of both the physical and the neurological phenotype, made molecular testing for PTHS the first choice. Based on striking clinical criteria, a diagnosis of PTHS was made clinically in two patients who had normal TCF4. This report deals with the first series of PTHS patients of Italian origin.
- Published
- 2011
42. Norovirus Gastroenteritis and Seizures: An Atypical Case with Neuroradiological Abnormalities
- Author
-
Bartolini, L., additional, Mardari, R., additional, Toldo, I., additional, Calderone, M., additional, Battistella, P., additional, Laverda, A., additional, and Sartori, S., additional
- Published
- 2011
- Full Text
- View/download PDF
43. Hemiconvulsion–hemiplegia–epilepsy syndrome: Early magnetic resonance imaging findings and neuroradiological follow-up
- Author
-
Toldo, I., primary, Calderone, M., additional, Boniver, C., additional, Dravet, Ch., additional, Guerrini, R., additional, and Laverda, A.M., additional
- Published
- 2007
- Full Text
- View/download PDF
44. Description and Clinical Signs and Symptoms of the Main Forms of Simple Craniosynostosis
- Author
-
Toldo, I., primary and Drigo, P., additional
- Published
- 2005
- Full Text
- View/download PDF
45. Multimodal neuroimaging in a child with sporadic hemiplegic migraine: a contribution to understanding pathogenesis.
- Author
-
Toldo I, Cecchin D, Sartori S, Calderone M, Mardari R, Cattelan F, Laverda AM, Drigo P, Battistella PA, Toldo, Irene, Cecchin, Diego, Sartori, Stefano, Calderone, Milena, Mardari, Rodica, Cattelan, Francesca, Laverda, Anna Maria, Drigo, Paola, and Battistella, Pier Antonio
- Abstract
Background: Hemiplegic migraine (HM) is a rare variety of migraine with aura, characterized by motor deficits during the aura, often beginning in childhood. The hemiplegic attacks can be severe and prolonged but the prognosis is usually good. Data on neuroimaging, including diffusion-weighted imaging (DWI) and spectroscopy, during prolonged attacks of HM are quite limited, particularly in children.Case: An eight-year-old female had a prolonged attack of sporadic HM characterized by right-sided hemiplegia, global aphasia, fever and impairment of consciousness. MRI nine hours after hemiplegia onset was negative, while the following MRI scans (days 4 and 11) documented a progressive increase in cortical swelling in the left hemisphere with mild hyperintensity on DWI and mild reduction of apparent diffusion coefficient values. Proton MRI spectroscopy (MRS) (day 15) showed a decrease in the N-acetylaspartate/creatine ratio in the left hemisphere. (99m)Tc-ECD single-photon emission tomography (SPET) (day 27) showed marked left hemispheric hypoperfusion. The patient recovered completely after 40 days and neuroimaging follow-up (MRI and SPET) after six months was normal. The patient carried a missense mutation of the ATP1A2 gene.Conclusion: Multimodal neuroimaging (MRI, DWI, MRS, SPET) in a prolonged HM attack supports evidence for a primary neuronal dysfunction. [ABSTRACT FROM AUTHOR]- Published
- 2011
- Full Text
- View/download PDF
46. Description and Clinical Signs and Symptoms of the Main Forms of Simple Craniosynostosis
- Author
-
Toldo, I. and Drigo, P.
- Abstract
Craniosynostosis, a skull growth disorder due to premature fusion of one or more sutures, is a common clinical problem requiring the attention of many specialists. In simple craniosynostosis (stenosis of a single suture) symptoms are usually mild: signs of intracranial hypertension, mental deficiency, visual or hearing problema are rare, whereas learning disorders or aesthetic and psychological problema are more common. Considering the data in the literature, we analyze the clinical presentation of the main forms of simple craniosynostosis (scaphocephaly, trigonocephaly, brachycephaly, plagiocephaly), their assessment, when measuring intracranial pressure can be useful and whether surgery affects late cognitive outcome.
- Published
- 2005
- Full Text
- View/download PDF
47. Operational scenarios simulation to support building design: A hospital design case study
- Author
-
Simeone, D., Toldo, I., and STEFANO CURSI
- Subjects
Operational simulation ,hospital design ,Building use simulation ,Virtual environment ,BPMN
48. Plasma exchange in pediatric anti-NMDAR encephalitis: A systematic review.
- Author
-
Suppiej, A., Nosadini, M., Zuliani, L., Pelizza, M. F., Toldo, I., Bertossi, C., Tison, T., Zoccarato, M., Marson, P., Giometto, B., Dale, R. C., and Sartori, S.
- Subjects
- *
TREATMENT of encephalitis , *PLASMA exchange (Therapeutics) , *METHYL aspartate receptors , *IMMUNOTHERAPY , *DRUG administration , *SYSTEMATIC reviews - Abstract
OBJECTIVE: To clarify the most frequent modalities of use of plasma exchange (PE) in pediatric anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis and to establish the most effective association with other immunotherapies. METHODS: Systematic literature review on PE in pediatric anti-NMDAR encephalitis (2007-2015). RESULTS: Seventy-one articles were included (mostly retrospective), reporting a total of 242 subjects (73.2%, 93/127 females; median age at onset 12years, range 1-18). Median time to immunotherapy was 21days (range 0-190). In most cases, PE was given with steroids and IVIG (69.5%, 89/128), or steroids only (18%, 23/128); in a minority, it was associated with IVIG only (7%, 9/128), or was the only first-line treatment (5.5%, 7/128). In 54.5% (65/119), PE was the third treatment after steroids and IVIG, in 31.1% (37/119) the second after steroids or IVIG; only in 14.3% (17/119) was it the first treatment. Second-line immunotherapies were administered in 71.9% (100/139). Higher rates of full/substantial recovery at follow-up were observed with immunotherapy given ?30days from onset (69.4%, 25/36) compared to later (59.2%, 16/27), and when PE was associated with steroids (66.7%, 70/105) rather than not (46.7%, 7/15). Significant adverse reactions to PE were reported in 6 patients. CONCLUSION: Our review disclosed a paucity of quality data on PE in pediatric anti-NMDAR encephalitis. PE use in this condition has been increasingly reported, most often with steroids and IVIG. Despite the limited number of patients, our data seem to confirm the trend towards a better outcome when PE was administered early, and when given with steroids. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
49. I stay at home with headache. A survey to investigate how the lockdown for COVID-19 impacted on headache in Italian children
- Author
-
Matteo Battisti, Agnese Onofri, Noemi Faedda, Samuela Tarantino, Pierfrancesco Alaimo Di Loro, Paola Verdecchia, Federico Vigevano, Licia Grazzi, Vincenzo Raieli, Vittorio Sciruicchio, Maria Federica Pelizza, Michela An Ferilli, Massimiliano Valeriani, Fabiana Ursitti, Giulia Natalucci, Elisabetta Tozzi, Vincenzo Guidetti, Romina Moavero, Daniela D'Agnano, Margherita Velardi, Giovanni Grillo, Irene Toldo, Angela Celi, Pasquale Parisi, Cristiano Termine, Martina Balestri, Michelangelo Vasta, Marco Carotenuto, Laura Papetti, Papetti, L., Loro, P. A. D., Tarantino, S., Grazzi, L., Guidetti, V., Parisi, P., Raieli, V., Sciruicchio, V., Termine, C., Toldo, I., Tozzi, E., Verdecchia, P., Carotenuto, M., Battisti, M., Celi, A., D'Agnano, D., Faedda, N., Ferilli, M. A. N., Grillo, G., Natalucci, G., Onofri, A., Pelizza, M. F., Ursitti, F., Vasta, M., Velardi, M., Balestri, M., Moavero, R., Vigevano, F., and Valeriani, M.
- Subjects
Male ,Anxiety ,lockdown ,0302 clinical medicine ,COVID-19 ,lifestyle ,migraine ,adolescent ,anxiety ,betacoronavirus ,child ,female ,headache ,humans ,Italy ,male ,SARS-CoV-2 ,social isolation ,surveys and questionnaires ,coronavirus infections ,life style ,pandemics ,pneumonia ,viral ,Surveys and Questionnaires ,Medicine ,Surveys and Questionnaire ,030212 general & internal medicine ,Viral ,Social isolation ,Child ,education.field_of_study ,Headache ,General Medicine ,Settore MED/39 ,pneumonia, viral ,covid-19 ,Social Isolation ,Female ,medicine.symptom ,Coronavirus Infections ,medicine.drug ,Human ,Topiramate ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Population ,Pneumonia, Viral ,03 medical and health sciences ,Betacoronavirus ,Humans ,education ,Psychiatry ,Pandemics ,Life Style ,Migraine ,Special Section Articles ,Betacoronaviru ,Pandemic ,business.industry ,Coronavirus Infection ,Pneumonia ,medicine.disease ,Mood ,Etiology ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective The present Italian multicenter study aimed at investigating whether the course of primary headache disorders in children and adolescents was changed during the lockdown necessary to contain the COVID-19 emergency in Italy. Methods During the lockdown, we submitted an online questionnaire to patients already diagnosed with primary headache disorders. Questions explored the course of headache, daily habits, psychological factors related to COVID-19, general mood and school stress. Answers were transformed into data for statistical analysis. Through a bivariate analysis, the main variables affecting the subjective trend of headache, and intensity and frequency of the attacks were selected. The significant variables were then used for the multivariate analysis. Results We collected the answers of 707 patients. In the multivariate analysis, we found that reduction of school effort and anxiety was the main factor explaining the improvement in the subjective trend of headache and the intensity and frequency of the attacks ( p 0.05), presence of chronic headache disorders ( p > 0.05) and geographical area ( p > 0.05). Conclusions Our study showed that lifestyle modification represents the main factor impacting the course of primary headache disorders in children and adolescents. In particular, reduction in school-related stress during the lockdown was the main factor explaining the general headache improvement in our population.
- Published
- 2020
50. Headache attributed to aeroplane travel: the first multicentric survey in a paediatric population affected by primary headaches
- Author
-
Sergio Zanini, Agnese Maria Tamborino, Vittorio Sciruicchio, Barbara Bolzonella, Maria Giuseppina Ledda, Irene Toldo, Pier Antonio Battistella, Stefano Sartori, Vincenzo Raieli, Michela Gatta, Lucia Margari, Alberto Verrotti, A Vecchio, Margherita Santucci, D De Carlo, De Carlo D., Toldo I., Tamborino A.M., Bolzonella B., Ledda M.G., Margari L., Raieli V., Santucci M., Sciruicchio V., Vecchio A., Zanini S., Sartori S., Gatta M., Verrotti A., and Battistella P.A.
- Subjects
Male ,Pediatrics ,Neurology ,Photophobia ,Aircraft ,Headache Disorder ,lcsh:Medicine ,Airplane ,0302 clinical medicine ,Surveys and Questionnaires ,Surveys and Questionnaire ,030212 general & internal medicine ,Child ,Children ,Aeroplane travel ,Pain Measurement ,Travel ,ICHD-III ,Headache ,General Medicine ,Pediatric headache ,Phonophobia ,Italy ,Child, Preschool ,Female ,medicine.symptom ,Research Article ,Human ,Adult ,medicine.medical_specialty ,Adolescent ,Headache Disorders ,03 medical and health sciences ,Primary headache ,Primary headaches ,medicine ,Humans ,Preschool ,business.industry ,lcsh:R ,Mean age ,Anesthesiology and Pain Medicine ,Concomitant ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Paediatric population - Abstract
BACKGROUND: This multicentric survey investigates the prevalence and characteristics of Airplane Headache in children affected by primary headaches. METHODS: Patients with symptoms of Airplane Headache were recruited from nine Italian Pediatric Headache Centres. Each patient was handed a structured questionnaire which met the ICHD-III criteria. RESULTS: Among 320 children suffering from primary headaches who had flights during their lifetime, 15 (4.7%) had Airplane Headache, with mean age of 12.4years. Most of the patients were females (80%). The headache was predominantly bilateral (80%) and localized to the frontal area (60%); it was mainly pulsating, and lasted less than 30min in all cases. Accompanying symptoms were tearing, photophobia, phonophobia in most of the cases (73.3%). More than 30% of patients used medications to treat the attacks, with good results. CONCLUSION: Our study shows that Airplane Headache is not a rare disorder in children affected by primary headaches and highlights that its features in children are peculiar and differ from those described in adults. In children Airplane Headache prevails in females, is more often bilateral, has frequently accompanying symptoms and occurs at any time during the flight. Further studies are needed to confirm the actual frequency of Airplane Headache in the general pediatric population not selected from specialized Headache Centres, with and without other concomitant headache condition, and to better clarify the clinical characteristics, pathophysiology and potential therapies.
- Published
- 2018
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.