169 results on '"Toldo, I."'
Search Results
2. Primary Stabbing Headache in Children and Adolescents
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Reimers, M., primary, Bonemazzi, I., additional, Brunello, F., additional, Cavaliere, E., additional, Sartori, S., additional, and Toldo, I., additional
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- 2024
- Full Text
- View/download PDF
3. Sleep disorders and neuropsychiatric disorders in a pediatric sample of tuberous sclerosis complex: a questionnaire-based study
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Moavero, R., primary, Voci, A., additional, La Briola, F., additional, Matricardi, S., additional, Toldo, I., additional, Mancardi, M., additional, Negrin, S., additional, Vigevano, F., additional, Mazzone, L., additional, Valeriani, M., additional, Curatolo, P., additional, and Bruni, O., additional
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- 2022
- Full Text
- View/download PDF
4. Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication
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Verrotti, A., Laino, D., Rinaldi, V. E., Suppiej, A., Giordano, L., Toldo, I., Margari, L., Parisi, P., Rizzo, R., Matricardi, S., Cusmai, R., Grosso, S., Gaggero, R., Zamponi, N., Pavone, P., Capovilla, G., Rauchenzauner, M., Cerminara, C., Di Gennaro, G., Esposito, M., Striano, P., Savasta, S., Coppola, G., Siliquini, S., Operto, F., Belcastro, V., Ragona, F., Marseglia, G. L., and Spalice, A.
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- 2016
- Full Text
- View/download PDF
5. Relapse risk factors in anti-N-methyl-D-aspartate receptor encephalitis
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Nosadini, Margherita, Granata, Tiziana, Matricardi, Sara, Freri, Elena, Ragona, Francesca, Papetti, Laura, Suppiej, Agnese, Valeriani, Massimiliano, Sartori, Stefano, Italian Working Group on Paediatric Anti-N-methyl-D-aspartate Receptor Encephalitis, Bonuccelli, A, Beccaria, F, Buechner, S, Buratti, S, Cantalupo, G, Cappellari, A, Casellato, S, Cesaroni, E, Cimaz, R, Cordelli, Dm, Costa, P, Dell'Avvento, S, Dilena, R, Falsaperla, R, Foiadelli, T, Frigo, Ac, Fusco, L, Giacobbe, A, Giannotta, M, Grazian, L, Maggio, Mc, Mancardi, Mm, Melis, M, Natali Sora MG, Orsini, A, Petruzzellis, A, Pini, A, Pruna, D, Santangelo, G, Savasta, S, Scaduto, Mc, Serino, D, Simula, D, Solazzi, R, Sotgiu, S, Splendiani, A, Toldo, I, Vigevano, F, Viri, M, Visconti, P, Zamponi, N, Zanus, C, Zoccarato, M, Zuliani, L, Nosadini M., Granata T., Matricardi S., Freri E., Ragona F., Papetti L., Suppiej A., Valeriani M., Sartori S., Bonuccelli A., Beccaria F., Buechner S., Buratti S., Cantalupo G., Cappellari A., Casellato S., Cesaroni E., Cimaz R., Cordelli D.M., Costa P., Dell'Avvento S., Dilena R., Falsaperla R., Foiadelli T., Frigo A.C., Fusco L., Giacobbe A., Giannotta M., Grazian L., Maggio M.C., Mancardi M.M., Melis M., Natali Sora M.G., Orsini A., Petruzzellis A., Pini A., Pruna D., Santangelo G., Savasta S., Scaduto M.C., Serino D., Simula D., Solazzi R., Sotgiu S., Splendiani A., Toldo I., Vigevano F., Viri M., Visconti P., Zamponi N., Zanus C., Zoccarato M., and Zuliani L.
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Male ,030506 rehabilitation ,Gastroenterology ,Cohort Studies ,0302 clinical medicine ,Retrospective Studie ,Modified Rankin Scale ,Recurrence ,Risk Factors ,Child ,relapse ,Anti-N-Methyl-D-Aspartate Receptor Encephalitis ,Hazard ratio ,Italy ,Child, Preschool ,Cohort ,anti‐N‐methyl‐D‐aspartate receptor encephalitis ,Female ,0305 other medical science ,Encephalitis ,Human ,Cohort study ,medicine.medical_specialty ,Adolescent ,Socio-culturale ,anti-NMDAR antibodies ,03 medical and health sciences ,anti-NMDAR ,Developmental Neuroscience ,Internal medicine ,medicine ,Humans ,Infant ,Retrospective Studies ,Preschool ,Survival analysis ,Autoimmune encephalitis ,business.industry ,Retrospective cohort study ,medicine.disease ,anti-NMDAR antibodies, autoimmune encephalitis, anti‐N‐methyl‐D‐aspartate receptor encephalitis ,autoimmune encephalitis ,Anti-N-methyl-D-aspartate receptor encephalitis, anti-NMDAR, autoimmune encephalitis, relapse ,Anti-N-Methyl-D-Aspartate Receptor Encephaliti ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Cohort Studie ,business ,030217 neurology & neurosurgery - Abstract
Aim: To identify factors that may predict and affect the risk of relapse in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Method: This was a retrospective study of an Italian cohort of patients with paediatric (≤18y) onset anti-NMDAR encephalitis. Results: Of the 62 children included (39 females; median age at onset 9y 10mo, range 1y 2mo–18y; onset between 2005 and 2018), 21 per cent relapsed (median two total events per relapsing patient, range 2–4). Time to first relapse was median 31.5months (range 7–89mo). Severity at first relapse was lower than onset (median modified Rankin Scale [mRS] 3, range 2–4, vs median mRS 5, range 3–5; admission to intensive care unit: 0/10 vs 3/10). At the survival analysis, the risk of relapsing was significantly lower in patients who received three or more different immune therapies at first disease event (hazard ratio 0.208, 95% confidence interval 0.046–0.941; p=0.042). Neurological outcome at follow-up did not differ significantly between patients with relapsing and monophasic disease (mRS 0–1 in 39/49 vs 12/13; p=0.431), although follow-up duration was significantly longer in relapsing (median 84mo, range 14–137mo) than in monophasic patients (median 32mo, range 4–108mo; p=0.002). Interpretation: Relapses may occur in about one-fifth of children with anti-NMDAR encephalitis, are generally milder than at onset, and may span over a long period, although they do not seem to be associated with severity in the acute phase or with outcome at follow-up. Aggressive immune therapy at onset may reduce risk of relapse. What this paper adds: Relapses of anti-N-methyl-D-aspartate receptor encephalitis may span over a long period. Relapses were not associated with severity in the acute phase or outcome at follow-up. Aggressive immune therapy at onset appears to decrease risk of relapse.
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- 2019
6. NEW OBSERVATIONAL AND CLINICAL METHODS IN THE TREATMENT OF DEVELOPMENTAL AGE PSYCHOPATHOLOGY
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Gatta, M., Miscioscia, M., Svanellini, L., Sisti, M., Sudati, L., Comis, I., Toldo, I., Battistella, P. A., and Simonelli, A.
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- 2018
7. Manuale di neuropsichiatria infantile e dell'adolescenza
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Battistella, P. A., Toldo, I., De Carlo, D., Sartori, S., and Gatta, M.
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- 2018
8. Pyridoxine-dependent epilepsies: an observational study on clinical, diagnostic, therapeutic and prognostic features in a pediatric cohort
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Falsaperla, R, Vari, Ms, Toldo, I, Murgia, A, Sartori, S, Vecchi, M, Suppiej, A, Burlina, A, Mastrangelo, M, Leuzzi, V, Marchiani, V, De Liso, P, Capovilla, G, Striano, P, Vitaliti, G, and Italian Society of Pediatric Neurology (SINP: Società Italiana di Neurologia, Pediatrica).
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Male ,medicine.medical_specialty ,Pediatrics ,Neurology ,Adolescent ,medicine.medical_treatment ,Cohort ,Dependent epilepsies ,Diagnosis ,Observational study ,Pediatric age ,Pyridoxine ,Treatment ,Anticonvulsants ,Child ,Child, Preschool ,Cohort Studies ,Epilepsy ,Female ,Humans ,Infant ,Retrospective Studies ,Seizures ,Vitamin B Complex ,Biochemistry ,NO ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Pathognomonic ,030225 pediatrics ,Medicine ,Preschool ,Adverse effect ,business.industry ,Retrospective cohort study ,Anticonvulsant ,pyridoxine ,dependent epilepsies ,diagnosis ,treatment ,pediatric age ,observational study ,cohort ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The aim of our study was to describe the clinical, electroencephalogram, molecular findings and the diagnostic and therapeutic flow-chart of children with pyridoxine-dependent epilepsies (PDEs). We performed a retrospective observational study on children with PDEs, diagnosed and followed-up in Italian Pediatric Departments. In each centre, the authors collected data from a cohort of children admitted for intractable seizures, responsive to pyridoxine administration and resistant to other anticonvulsant therapies. Data were retrospectively analysed from January 2016 to January 2017. Sixteen patients (13 males, and 3 females) were included. We found that 93.75% of patients underwent conventional anticonvulsant therapy before starting pyridoxine administration and 62.5% had ex-juvantibus diagnosis, as specific serum diagnostic tests had been performed in only 37.5% of patients by alpha-AASA and pipecolic acid blood and urine dosage. The most common type of seizure was generalized tonic-clonic in 7 patients and the most common EEG pattern was characterized by a "burst suppression" pattern. Before pyridoxine administration, other anticonvulsant drugs were used in 93.75% of patients, with consequent onset of drug-resistance. Phenobarbital was the most frequently used drug as first-line treatment. The importance of our study relies on the need of a deeper knowledge of PDEs in terms of early diagnosis, avoiding incorrect treatment and related adverse events, clinical and EEG pathognomonic features, and genetic aspects of the disease.
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- 2017
9. Neuroimaging Changes in Menkes Disease, Part 1
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Manara, R, D'Agata, L, Rocco, Mc, Cusmai, R, Freri, E, Pinelli, L, Darra, Francesca, Procopio, E, Mardari, R, Zanus, C, Di Rosa, G, Soddu, C, Severino, M, Ermani, M, Longo, D, Sartori, S, Menkes Working Group in the Italian Neuroimaging Network for Rare Diseases: Toldo, I, Peruzzi, C, Vittorini, R, Spalice, A, Fusco, C, Nosadini, M, Farina, L, Stecco, A, Polonara, G, Donati, Ma, Giordano, L, Dionisi Vici, C, Martinelli, D, Tocchet, A, Fariello, G, Nicita, F, Frattini, D, Martelli, P, Cantalupo, Gaetano, and Zennaro, F.
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Menkes disease, neuroimaging, MRI ,Male ,Pathology ,medicine.medical_specialty ,vascular abnormalities ,Neuroimaging ,Disease ,Pediatrics ,030218 nuclear medicine & medical imaging ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Menkes Kinky Hair Syndrome ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,Retrospective cohort study ,Menkes disease ,medicine.disease ,White matter changes ,Magnetic Resonance Imaging ,White Matter ,X-linked disorder ,myelination delay ,medicine.anatomical_structure ,myelination delay, vascular abnormalities, X-linked disorder, copper metabolism ,Disease Progression ,Female ,copper metabolism ,Neurology (clinical) ,business ,Neuroscience ,030217 neurology & neurosurgery ,MRI - Abstract
Menkes disease is a rare multisystem X-linked disorder of copper metabolism. Despite an early, severe, and progressive neurologic involvement, our knowledge of brain involvement remains unsatisfactory. The first part of this retrospective and review MR imaging study aims to define the frequency rate, timing, imaging features, and evolution of intracranial vascular and white matter changes. According to our analysis, striking but also poorly evolutive vascular abnormalities characterize the very early phases of disease. After the first months, myelination delay becomes evident, often in association with protean focal white matter lesions, some of which reveal an age-specific brain vulnerability. In later phases of the disease, concomitant progressive neurodegeneration might hinder the myelination progression. The currently enriched knowledge of neuroradiologic finding evolution provides valuable clues for early diagnosis, identifies possible MR imaging biomarkers of new treatment efficacy, and improves our comprehension of possible mechanisms of brain injury in Menkes disease.
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- 2017
10. Neuroimaging Changes in Menkes Disease, Part 2
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Manara, R, Rocco, M C, D'Agata, L, Cusmai, R, Freri, E, Giordano, L, Darra, F, Procopio, E, Toldo, I, Peruzzi, C, Vittorini, R, Spalice, A, Fusco, C, Nosadini, M, Longo, D, Sartori, S, Menkes Working Group in the Italian Neuroimaging Network for Rare Diseases, Mardari, R, Zanus, C, Di Rosa, G, Soddu, C, Severino, M, Ermani, M, Farina, L, Stecco, A, Polonara, G, Donati, Ma, Pinelli, L, Dionisi-Vici, C, Martinelli, D, Tocchet, A, Fariello, G, Nicita, F, Frattini, D, Martelli, P, Cantalupo, G, and Zennara, F
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Child abuse ,Male ,Pathology ,medicine.medical_specialty ,Neuroimaging ,Disease ,Pediatrics ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,gray matter changes, X-linked disorder, copper metabolism, neurodegeneration, basal ganglia lesions, subdural collections ,Basal ganglia ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Gray Matter ,Child ,Menkes Kinky Hair Syndrome ,Retrospective Studies ,gray matter changes ,medicine.diagnostic_test ,business.industry ,neurodegeneration ,Brain ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,basal ganglia lesions ,subdural collections ,X-linked disorder ,Menkes disease ,Neurology (clinical) ,copper metabolism ,Differential diagnosis ,business ,030217 neurology & neurosurgery ,Rare disease - Abstract
This is the second part of a retrospective and review MR imaging study aiming to define the frequency rate, timing, imaging features, and evolution of gray matter changes in Menkes disease, a rare multisystem X-linked disorder of copper metabolism characterized by early, severe, and progressive neurologic involvement. According to our analysis, neurodegenerative changes and focal basal ganglia lesions already appear in the early phases of the disease. Subdural collections are less common than generally thought; however, their presence remains important because they might challenge the differential diagnosis with child abuse and might precipitate the clinical deterioration. Anecdotal findings in our large sample seem to provide interesting clues about the protean mechanisms of brain injury in this rare disease and further highlight the broad spectrum of MR imaging findings that might be expected while imaging a child with the suspicion of or a known diagnosis of Menkes disease.
- Published
- 2017
11. Nutraceuticals and herbs in the treatment of pediatric primary headaches in 11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches : Rome, Italy. 01-03 December 2017
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Piretti, E, Toldo, I, Rossaro, Mp, Sartori, S, Gatta, M, Nosadini, M, and Battistella, Pa
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TENSION-TYPE ,DOUBLE-BLIND ,MELATONIN ,HEADACHE ,MIGRAINE ,MAGNESIUM ,CHILDREN ,COENZYME Q10 ,PREVENTION ,PROPHYLAXIS ,TENSION-TYPE, HEADACHE, DOUBLE-BLIND, DOSE RIBOFLAVIN, MIGRAINE, PROPHYLAXIS, CHILDREN,COENZYME Q10, PREVENTION, MELATONIN, MAGNESIUM ,DOSE RIBOFLAVIN - Published
- 2017
12. Erratum to: Oculo-auriculo-vertebral spectrum: going beyond the first and second pharyngeal arch involvement (Neuroradiology, (2017), 59, 3, (305-316), 10.1007/s00234-017-1795-1)
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Brotto, D., Manara, R., Ghiselli, S., Lovo, E., Mardari, R., Toldo, I., Castiglione, A., Schifano, G., Stritoni, V., Bovo, R., Trevisi, P., and Martini, A.
- Published
- 2017
13. Headache and recurrent abdominal pains in preschool children
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Battistella, P. A. and Toldo, I.
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- 2006
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- View/download PDF
14. Long-term outcome of epilepsy in patients with prader–willi syndrome
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Verrotti A, Cusmai R, Laino D, CAROTENUTO, Marco, ESPOSITO, Maria, Falsaperla R, Margari L, Rizzo R, Savasta S, Grosso S, Striano P, Belacastro V, Franzoni E, Curatolo P, Giordano L, Freri E, Matricardi S, Pruna D, Toldo I, Tozzi E, Lobefalo L, Operto F, Altobelli E, Chiarelli F, Spalice A., Verrotti, A, Cusmai, R, Laino, D, Carotenuto, Marco, Esposito, Maria, Falsaperla, R, Margari, L, Rizzo, R, Savasta, S, Grosso, S, Striano, P, Belacastro, V, Franzoni, E, Curatolo, P, Giordano, L, Freri, E, Matricardi, S, Pruna, D, Toldo, I, Tozzi, E, Lobefalo, L, Operto, F, Altobelli, E, Chiarelli, F, and Spalice, A.
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Epilepsy ,Prader–Willi syndrome ,EEG ,Long term outcome - Abstract
Prader-Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader-Willi syndrome patients suffering from epilepsy. We retrospectively studied 38 patients with Prader-Willi syndrome and seizures. Results of neuroimaging studies were obtained for 35 individuals. We subdivided these patients into two groups: group A, 24 patients, without brain lesions; and group B, 11 patients, with brain abnormalities. All patients were re-evaluated after a period of at least 10 years. Twenty-one patients (55.2 %) were affected by generalized epilepsy and 17 patients (44.8 %) presented focal epilepsy. The most common seizure type was generalized tonic-clonic seizure. The mean age at seizure onset was 4.5 years (ranged from 1 month to 14 years). In the follow-up period, seizure freedom was achieved in 32 patients (84.2 %). Seizure freedom was associated with electroencephalographic normalization, while the six children presenting drug-resistant epilepsy showed persistence of electroencephalographic abnormalities. Group B patients showed a higher prevalence of drug-resistant epilepsy. Patients with Prader-Willi syndrome were frequently affected by generalized seizures. Most of the patients had a favorable evolution, although, patients with brain abnormalities presented a worse outcome, suggesting that the presence of these lesions can influence the response to antiepileptic therapy. Prader–Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader–Willi syndrome patients suffering from epilepsy. We retrospectively studied 38 patients with Prader–Willi syndrome and seizures. Results of neuroimaging studies were obtained for 35 individuals. We subdivided these patients into two groups: group A, 24 patients, without brain lesions; and group B, 11 patients, with brain abnormalities. All patients were re-evaluated after a period of at least 10 years. Twenty-one patients (55.2 %) were affected by generalized epilepsy and 17 patients (44.8 %) presented focal epilepsy. The most common seizure type was generalized tonic– clonic seizure. The mean age at seizure onset was 4.5 years (ranged from 1 month to 14 years). In the follow-up period, seizure freedom was achieved in 32 patients (84.2 %). Seizure freedom was associated with electroencephalographic normalization, while the six children presenting drug-resistant epilepsy showed persistence of electroencephalographic abnormalities. Group B patients showed a higher prevalence of drug-resistant epilepsy. Patients with Prader–Willi syndrome were frequently affected by generalized seizures. Most of the patients had a favorable evolution, although, patients with brain abnormalities presented a worse outcome, suggesting that the presence of these lesions can influence the response to antiepileptic therapy.
- Published
- 2015
15. Clinical guidelines in pediatric headache: evaluation of quality using the AGREE II instrument
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Parisi, P, Vanacore, N, Belcastro, V, Carotenuto, M, Giudice, Ed, Mariani, R, Papetti, L, Pavone, P, Savasta, S, Striano, P, Toldo, I, Tozzi, Elisabetta, Verrotti, A, Raucci, U, 'Pediatric Headache Commission' of Società Italiana di Neurologia, P. e. d. i. a. t. r. i. c. a., VERROTTI di PIANELLA, Alberto, Parisi, P, Vanacore, N, Belcastro, V, Carotenuto, Marco, Del Giudice, E, Mariani, R, Papetti, L, Pavone, P, Savasta, S, Striano, P, Toldo, I, Tozzi, E, Verrotti, A, Raucci, U., Carotenuto, M, and DEL GIUDICE, Ennio
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medicine.medical_specialty ,media_common.quotation_subject ,Clinical Neurology ,Nice ,Agree II instrument ,Children ,Guidelines ,Pediatric headache ,Quality of guidelines ,Child ,Evidence-Based Medicine ,Headache ,Humans ,Pediatrics ,Practice Guidelines as Topic ,Quality of Health Care ,State Medicine ,Anesthesiology and Pain Medicine ,Neurology (clinical) ,Medicine (all) ,Cephalalgia ,medicine ,Quality (business) ,Pediatricagree II instrument ,Psychiatry ,National Guideline Clearinghouse ,book ,media_common ,computer.programming_language ,book.periodical ,guidelines ,pediatric headache ,quality of guidelines ,child ,evidence-based medicine ,headache ,humans ,childrens ,practice guidelines as topic ,quality of health care ,state medicine ,neurology (clinical) ,anesthesiology and pain medicine ,business.industry ,General Medicine ,Evidence-based medicine ,Guideline ,Quality Score ,Inclusion and exclusion criteria ,Physical therapy ,business ,computer ,Research Article - Abstract
Background The Appraisal of Guidelines for Research and Evaluation (AGREE II) tool is a validated questionnaire used to assess the methodological quality of clinical guidelines (CGs). We used the AGREE II tool to assess the development process, the methodological quality, and the quality of reporting of available pediatric CGs for the management of headache in children. We also studied the variability in responses related to the characteristics of eleven Italian neuropediatric centers, showing similarities and differences in the main recommendations reported in CGs. Methods A systematic literature search was conducted from January 2002 to June 2013 on Mediline, the Cochrane database, the National Guideline Clearinghouse website and the NHS evidence search tool, using the following terms: headache, cephalalgia, guidelines and children (MESH or text words). Six CGs providing information on the diagnosis and management of headache and specific recommendations for children were selected. Eleven neuropediatric centers assessed the overall quality and the appropriateness of all available CGs using of the AGREE II instrument. Results Six CGs meeting the inclusion and exclusion criteria were identified and assessed by 11 reviewers. Our study showed that the NICE CGs was “strongly recommended” while the French and Danish CGs were mainly “not recommended”. The comparison between the overall quality score of the French CGs and the NICE CGs was statistically significant (6.54 ± 0.69 vs 4.18 ± 1.08; p =0.001). The correlation analysis between quality domain score and guideline publication date showed a statistically significant association only for the “editorial independence” domain (r = 0.842 p = 0.035). The intra-class coefficients showed that the 11 reviewers had the highest agreement for the Lewis CGs (r = 0.857), and the lowest one for the NICE CGs (r = 0.656). Statistical analyses showed that professionals from outpatient services dedicated pediatric headache assigned a higher overall quality score to the NICE CGs as compared to professionals from non-outpatient services (6.86 ± 0.38 vs 6.0 ± 0.82; p = 0.038). Conclusions CGs resulted definitely of low-moderate quality and non “homogeneous”. Further major efforts are needed to update the existing CGs according to the principles of evidence based medicine.
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- 2014
16. Pediatric moyamoya disease and syndrome in Italy: Data from the Italian Society of Pediatric Neurology multicentric retrospective study
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Sartori, S., primary, Po', C., additional, Carai, A., additional, Rosati, A., additional, Accorsi, P., additional, Iodice, A., additional, Savasta, S., additional, D'Avella, D., additional, Greco, F., additional, Raviglione, F., additional, Ragazzi, P., additional, Agostini, M., additional, Cesaroni, E., additional, Di Rosa, G., additional, Striano, P., additional, Nicita, F., additional, Cordelli, D., additional, Suppiej, A., additional, Nosadini, M., additional, Marras, C.E., additional, and Toldo, I., additional
- Published
- 2017
- Full Text
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17. Neuroimaging Changes in Menkes Disease, Part 2
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Manara, R., primary, Rocco, M.C., additional, D'agata, L., additional, Cusmai, R., additional, Freri, E., additional, Giordano, L., additional, Darra, F., additional, Procopio, E., additional, Toldo, I., additional, Peruzzi, C., additional, Vittorini, R., additional, Spalice, A., additional, Fusco, C., additional, Nosadini, M., additional, Longo, D., additional, and Sartori, S., additional
- Published
- 2017
- Full Text
- View/download PDF
18. Pharmacological treatment of primary headaches in children: a multicentre Italian study
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Toldo I, Rattin M, De Carlo D, Bolzonella B, Perissinotto E, Sartori S, Rossi LN, Vecchio A, Simonati A, Scalas C, Sciruicchio V, Raieli V, Mazzotta G, Balottin U, Tozzi E, Valeriani M, Cianchetti C, Guidetti V, Battistella PA, CAROTENUTO, Marco, Toldo, I, Rattin, M, De Carlo, D, Bolzonella, B, Perissinotto, E, Sartori, S, Rossi, Ln, Vecchio, A, Simonati, A, Carotenuto, Marco, Scalas, C, Sciruicchio, V, Raieli, V, Mazzotta, G, Balottin, U, Tozzi, E, Valeriani, M, Cianchetti, C, Guidetti, V, and Battistella, Pa
- Abstract
Introduction In the literature there are few data about the use of pharmacological treatments (acute and prophylaxis) of primary headaches [migraine (M), tension-type headache (TTH)] in children [1]. Materials and methods Retrospective multicentre study conducted in 13 Juvenile Headache Centres; inclusion criteria: 1) diagnosis of primary headache (ICHD-II 2004); 2) stable headache pattern (>6 months). Results Seven hundred and thirty-two cases (349 m, 383 f), mean age: 12 years. Headache types: M 68%, TTH 21%, M+TTH 5%, other 4%. The statistical analysis, conducted on patients with M or TTH (n=659), considered: efficacy and safety of several drugs, any differences based on age, diagnosis and geographical distribution. Symptomatic treatment: 93% of children (M 95%, TTH 88%); type of drug: paracetamol (M 75%, TTH 75%), NSAIDs (M 51%, TTH 27%), triptans (M 6%, TTH 0%); good-excellent efficacy 72%, good-excellent tolerability 92%. Prophylaxis therapy: 52% of cases (M 45%, TTH 44%); type of drug: flunarizine (M 18%, TTH 2%), pizotifen (M 6%, TTH 0%), amitriptyline (M 3%, TTH 5%), anticonvulsants (M 7%, TTH 1%), supplements (M 31%, TTH 34%), melatonin (M 10%, TTH 10%); good-excellent efficacy 76%, good-excellent tolerability 85%. Discussion and conclusions In our study population M prevails (76%). Symptomatic therapy is frequently used (93%), more often in M than TTH, with good efficacy and tolerability for all drugs; it is ineffective only in 10% of cases (range 7-23%). The use of NSAIDs prevail in M than TTH; few M (6%) use triptans. Prophylaxis therapy, prescribed in about half of cases (both in M and TTH), is ineffective in 12% of cases, but is usually well tolerated; supplements (32%) and flunarizine (14%) prevail.
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- 2013
19. A case of neonatal onset leucoencefalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) with rapid progression
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Boscardin, C., Sartori, S., Mardari, R., Talenti, G., Suppiej, A, and Toldo, I.
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NO - Published
- 2015
20. Congenital absence of gluteal muscles without spina bifida occulta: the first case report
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Vigo, G., Toldo, I., De Grandis, D., Beltrame, V., Sartori, S., and Suppiej, A
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Socio-culturale - Published
- 2015
21. Hemiplegic migraine: with onset in childhood:the first multicenter study
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Toldo, I., Rattin, M., Pelizza, M. F., Moscano, F., Tozzi, Elisabetta, Verrotti, A., Carotenuto, M., Lisotto, C., Ruffatti, S., Termine, C., Maggioni, F., Battistella, P. A., and S. S. A. R. T. O. R., I.
- Published
- 2015
22. Terapia delle cefalee primarie in età evolutiva: risultati preliminari di uno studio multicentrico italiano
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Toldo I, De Carlo D, Bolzonella B, Perissinotto E, Sartori S, Rossi LN, Vecchio A, Limonati A, Scalas C, Sciruicchio V, Raieli V, Mazzotta G, Balottin U, Tozzi E, Guidetti V, Battistella PA, CAROTENUTO, Marco, Toldo, I, De Carlo, D, Bolzonella, B, Perissinotto, E, Sartori, S, Rossi, Ln, Vecchio, A, Limonati, A, Carotenuto, Marco, Scalas, C, Sciruicchio, V, Raieli, V, Mazzotta, G, Balottin, U, Tozzi, E, Guidetti, V, and Battistella, Pa
- Published
- 2011
23. Treatment of primary headaches in children: preliminary results of a multicentre Italian study
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Toldo I, De Carlo D, Bolzonella D, Perissinotto E, Sartori S, Rossi LN, Vecchio A, Simonati A, Scalas C, Sciruicchio V, Raieli V, Mazzotta G, Balottin U, Tozzi E, Guidetti V, Battistella PA, CAROTENUTO, Marco, Toldo, I, De Carlo, D, Bolzonella, D, Perissinotto, E, Sartori, S, Rossi, Ln, Vecchio, A, Simonati, A, Carotenuto, Marco, Scalas, C, Sciruicchio, V, Raieli, V, Mazzotta, G, Balottin, U, Tozzi, E, Guidetti, V, and Battistella, Pa
- Abstract
Introduction The are few data in the literature about the use of pharmacological and non-pharmacological therapies for primary headaches (migraine: M; tension-type headache: TTH) in children [1]. Materials and methods A retrospective study was conducted by twelve Juvenile Headache Centres; inclusion criteria: (1) diagnosis of primary headache (ICHD-II, 2004); (2) stable headache pattern ([6 months). Results Three hundred and twenty cases (163 M, 157 F) with mean age at interview of 11.1 ± 3.2 years (1–19 years). Headache types: M 71% (MO 62%, MA 6%, chronic M 3%), TTH 20% (ETTH 17%, CTTH 3%), and M + TTH 7%, other 2%. A) Symptomatic treatment used in 92% of cases (1 drug 57%, 2 drugs 26%, 3 drugs 9%); M 95% versus TTH 82% (p\0.0002); type of drug: paracetamol (P) (M 84%, TTH 73%), NSAIDs (M 46%, TTH 24%), triptans (T) (M 5%, TTH 0%); good–excellent efficacy 53%, good–excellent tolerability 86%. Prescriber: paediatrician (47%), child neuropsychiatry (41%), self-prescription (10%). (B) Prophylaxis therapy used in 46% of cases (1 drug 31%, 2 drugs 11%, 3 drugs 4%); M 53% versus CT 29% (p\0.01); type of drug: flunarizine (M 22% vs. TTH 2%, p\0.0002), pizotifen (M 7%, TTH 0%), propranolol (M 3%, TTH 0%), amitriptyline (M 1%, TTH 2%), anticonvulsants (M 7%, TTH 0%), supplements (M 25%, TTH 19%), melatonin (M 4%, TTH 6%); good–excellent efficacy 65%, good– excellent tolerability 80%. Prescriber: paediatrician (14%), child neuropsychiatrist (84%), no self-prescription. (C) Non-pharmacological treatments (N = 27, 8%): relaxation/biofeedback (30%), cognitive-behavioural therapy (22%), homeopathy (15%), treatment of malocclusion (15%), acupuncture (7%), psychotherapy (7%) and biofeedback (4%). (D) Rating more effective therapy: pharmacological symptomatic (57%) than prophylaxis combined with symptomatic (25%) or alone (16%); better tolerated therapy: pharmacological symptomatic (57%), than prophylaxis combined with symptomatic (22%) or alone (18%). Main expectations of the patient: effect on pain (62%), speed of action (30%) and lack of side effects (21%). Discussion and conclusions The study population consists predominantly of migraineurs (71%). The therapy most widely used was symptomatic (92%), especially P or NSAIDs, with limited use of T (E 5%) with good efficacy and tolerability. The prophylactic drugs most used were supplements (25%) and flunarizine (22%), while AEDs were rarely used (7%). The prophylaxis was ineffective in a third of migraineurs (28–34%), although often well tolerated (43–60%). The non-pharmacological therapy was not widely used (7%) and rarely preferred by patients (2–3%).
- Published
- 2011
24. Headache in pediatric multiple sclerosis: data from Padua case series 2003-2013
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Nosadini, M, Sartori, S, Rossato, S, Toldo, I, Pelizza, Mf, De Carlo, D., Bolzonella, B, Perini, P, Gallo, P, Suppiej, A, and Battistella, Pa
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Socio-culturale - Published
- 2014
25. BIM AND KNOWLEDGE MANAGEMENT FOR BUILDING HERITAGE
- Author
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Simeone, D., STEFANO CURSI, Toldo, I., and Carrara, G.
- Subjects
BIM ,built heritage ,ontology-based systems ,knowledge management ,Archaeological investigation - Published
- 2014
26. Psychotherapy and Lausanne Trilogue Play: A Case Report
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Gatta, M, primary, Stucchi, M, additional, Svanellini, L, additional, Toldo, I, additional, Difronzo, M, additional, Sudati, L, additional, and Ferruzza, E, additional
- Published
- 2016
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27. Alliance with patient and collaboration with parents throughout the psychotherapeutic process with children and adolescents: a pilot study
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Gatta, M., Andrea Spoto, Svanellini, L., Lai, J., Toldo, I., Testa, C. P., and Battistella, P. A.
- Published
- 2012
28. Terapia delle cefalee primarie in età evolutiva: risultati preliminari di uno studio multicentrico
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Toldo, I., Bolzonella, B., De Carlo, D., Sartori, S., Rossi, L., Vecchio, A., Simonati, A., Carotenuto, M., Scalas, C., Raieli, V., Mazzotta, Giovanni, and Battistella, P. A.
- Published
- 2011
29. Treatment of primary headaches in children: Preliminary results of a multicentre Italian Study
- Author
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Toldo, I., De Carlo, D., Bolzonella, B., Perissinotto, E., Sartori, S., Vecchio, A., Scalas, C., Sciruicchio, V., Raieli, V., Mazzotta, Giovanni, Ballottin, U., Tozzi, E., Guidetti, V., and Battistella, Pa
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Pediatric headache - Published
- 2011
30. Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication
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Verrotti, A., primary, Laino, D., additional, Rinaldi, V. E., additional, Suppiej, A., additional, Giordano, L., additional, Toldo, I., additional, Margari, L., additional, Parisi, P., additional, Rizzo, R., additional, Matricardi, S., additional, Cusmai, R., additional, Grosso, S., additional, Gaggero, R., additional, Zamponi, N., additional, Pavone, P., additional, Capovilla, G., additional, Rauchenzauner, M., additional, Cerminara, C., additional, Di Gennaro, G., additional, Esposito, M., additional, Striano, P., additional, Savasta, S., additional, Coppola, G., additional, Siliquini, S., additional, Operto, F., additional, Belcastro, V., additional, Ragona, F., additional, Marseglia, G. L., additional, and Spalice, A., additional
- Published
- 2015
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31. PP13.1 – 2834: Paediatric anti-N-methyl-D-aspartate receptor encephalitis: The first Italian multicenter case series
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Sartori, S., primary, Pelizza, M.F., additional, Nosadini, M., additional, Cesaroni, E., additional, Falsaperla, R., additional, Capovilla, G., additional, Mancardi, M.M., additional, Santangelo, G., additional, Cantalupo, G., additional, Cappellari, A., additional, Costa, P., additional, Bernardina, B. Dalla, additional, Dilena, R., additional, Pruna, D., additional, Serino, D., additional, Vanadia, E., additional, Vigevano, F., additional, Zanus, C., additional, Toldo, I., additional, and Suppiej, A., additional
- Published
- 2015
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32. PP04.12 – 3020: Chromosomal rearrangements of 6p25.3 and Moyamoya syndrome: A non-incidental association
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Po, C., primary, Suppiej, A., additional, Causin, F., additional, Talenti, G., additional, D'Avella, D., additional, Sartori, S., additional, and Toldo, I., additional
- Published
- 2015
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33. P133 – 2909: Hemiplegic migraine with onset in childhood: The first multicenter Italian study
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Toldo, I., primary, Rattin, M., additional, Pelizza, M.F., additional, Moscano, F., additional, Tozzi, E., additional, Verrotti, A., additional, Carotenuto, M., additional, Lisotto, C., additional, Ruffatti, S., additional, Termine, C., additional, Maggioni, F., additional, Battistella, P.A., additional, and Sartori, S., additional
- Published
- 2015
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- View/download PDF
34. PP05.15 – 2915: A case of neonatal onset leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) with rapid progression
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Boscardin, C., primary, Sartori, S., additional, Mardari, R., additional, Suppiej, A., additional, and Toldo, I., additional
- Published
- 2015
- Full Text
- View/download PDF
35. PP09.14 – 2843: Congenital absence of gluteal muscles without spina bifida occulta: The first case report
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Vigo, G., primary, Toldo, I., additional, De Grandis, D., additional, Beltrame, V., additional, Sartori, S., additional, and Suppiej, A., additional
- Published
- 2015
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36. Cranial Nerve Abnormalities in Oculo-Auriculo-Vertebral Spectrum
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Manara, R., primary, Brotto, D., additional, Ghiselli, S., additional, Mardari, R., additional, Toldo, I., additional, Schifano, G., additional, Cantone, E., additional, Bovo, R., additional, and Martini, A., additional
- Published
- 2015
- Full Text
- View/download PDF
37. Neuropsychological outcome after paediatric temporal lobe surgery: Analysis of 6 cases [Outcome neuropsicologico del trattamento chirurgico dell'epilessia del lobo temporale in età pediatrica: Analisi di 6 casi]
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Stefano Sartori, Cendron, M., Toldo, I., Boniver, C., Mai, R., Lo Russo, G., and Vecchi, M.
- Published
- 2006
38. 114. Movement disorder and EEG patterns in anti-NMDAr antibodies encephalitis
- Author
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Nosadini, M., primary, Sartori, S., additional, Toldo, I., additional, Cappellari, A., additional, de Palma, L., additional, Cainelli, E., additional, Zuliani, L., additional, Giometto, B., additional, Boniver, C., additional, and Suppiej, A., additional
- Published
- 2013
- Full Text
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39. The Pitt-Hopkins syndrome: report of 16 new patients and clinical diagnostic criteria
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Marangi, Giuseppe, Ricciardi, Stefania, Orteschi, Daniela, Lattante, Serena, Murdolo, Marina, Dallapiccola, B, Biscione, Chiara, Lecce, Rosetta, Chiurazzi, Pietro, Romano, C, Greco, D, Pettinato, R, Sorge, G, Pantaleoni, C, Alfei, E, Toldo, I, Magnani, C, Bonanni, P, Martinez, F, Serra, G, Battaglia, Domenica Immacolata, Lettori, Donatella, Vasco, Gessica, Baroncini, A, Daolio, C, Zollino, Marcella, Marangi, Giuseppe (ORCID:0000-0002-6898-8882), Lattante, Serena (ORCID:0000-0003-2891-0340), Chiurazzi, Pietro (ORCID:0000-0001-5104-1521), Battaglia, Domenica Immacolata (ORCID:0000-0003-0491-4021), Zollino, Marcella (ORCID:0000-0003-4871-9519), Marangi, Giuseppe, Ricciardi, Stefania, Orteschi, Daniela, Lattante, Serena, Murdolo, Marina, Dallapiccola, B, Biscione, Chiara, Lecce, Rosetta, Chiurazzi, Pietro, Romano, C, Greco, D, Pettinato, R, Sorge, G, Pantaleoni, C, Alfei, E, Toldo, I, Magnani, C, Bonanni, P, Martinez, F, Serra, G, Battaglia, Domenica Immacolata, Lettori, Donatella, Vasco, Gessica, Baroncini, A, Daolio, C, Zollino, Marcella, Marangi, Giuseppe (ORCID:0000-0002-6898-8882), Lattante, Serena (ORCID:0000-0003-2891-0340), Chiurazzi, Pietro (ORCID:0000-0001-5104-1521), Battaglia, Domenica Immacolata (ORCID:0000-0003-0491-4021), and Zollino, Marcella (ORCID:0000-0003-4871-9519)
- Abstract
Pitt-Hopkins syndrome (PTHS) is characterized by severe intellectual disability, typical facial gestalt and additional features, such as breathing anomalies. Following the discovery of the causative haploinsufficiency of transcription factor 4 (TCF4), about 60 patients have been reported. We looked for TCF4 mutations in 63 patients with a suspected PTHS. Haploinsufficiency of TCF4 was identified in 14 patients, as a consequence of large 18q21.2 chromosome deletions involving TCF4 (2 patients), gene mutations (11 patients) and a t(14q;18q) balanced translocation disrupting TCF4 (one patient). By evaluating the clinical features of these patients, along with literature data, we noticed that, in addition to the typical facial gestalt, the PTHS phenotype results from the various combinations of the following characteristics: intellectual disability with severe speech impairment, normal growth parameters at birth, postnatal microcephaly, breathing anomalies, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities. Although PTHS is currently considered to be involved in differential diagnosis with Angelman and Rett syndromes, we found that combining the facial characteristics with a detailed analysis of both the physical and the neurological phenotype, made molecular testing for PTHS the first choice. Based on striking clinical criteria, a diagnosis of PTHS was made clinically in two patients who had normal TCF4. This report deals with the first series of PTHS patients of Italian origin.
- Published
- 2011
40. Norovirus Gastroenteritis and Seizures: An Atypical Case with Neuroradiological Abnormalities
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Bartolini, L., additional, Mardari, R., additional, Toldo, I., additional, Calderone, M., additional, Battistella, P., additional, Laverda, A., additional, and Sartori, S., additional
- Published
- 2011
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41. Hemiconvulsion–hemiplegia–epilepsy syndrome: Early magnetic resonance imaging findings and neuroradiological follow-up
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Toldo, I., primary, Calderone, M., additional, Boniver, C., additional, Dravet, Ch., additional, Guerrini, R., additional, and Laverda, A.M., additional
- Published
- 2007
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42. Description and Clinical Signs and Symptoms of the Main Forms of Simple Craniosynostosis
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Toldo, I., primary and Drigo, P., additional
- Published
- 2005
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43. Multimodal neuroimaging in a child with sporadic hemiplegic migraine: a contribution to understanding pathogenesis.
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Toldo I, Cecchin D, Sartori S, Calderone M, Mardari R, Cattelan F, Laverda AM, Drigo P, Battistella PA, Toldo, Irene, Cecchin, Diego, Sartori, Stefano, Calderone, Milena, Mardari, Rodica, Cattelan, Francesca, Laverda, Anna Maria, Drigo, Paola, and Battistella, Pier Antonio
- Abstract
Background: Hemiplegic migraine (HM) is a rare variety of migraine with aura, characterized by motor deficits during the aura, often beginning in childhood. The hemiplegic attacks can be severe and prolonged but the prognosis is usually good. Data on neuroimaging, including diffusion-weighted imaging (DWI) and spectroscopy, during prolonged attacks of HM are quite limited, particularly in children.Case: An eight-year-old female had a prolonged attack of sporadic HM characterized by right-sided hemiplegia, global aphasia, fever and impairment of consciousness. MRI nine hours after hemiplegia onset was negative, while the following MRI scans (days 4 and 11) documented a progressive increase in cortical swelling in the left hemisphere with mild hyperintensity on DWI and mild reduction of apparent diffusion coefficient values. Proton MRI spectroscopy (MRS) (day 15) showed a decrease in the N-acetylaspartate/creatine ratio in the left hemisphere. (99m)Tc-ECD single-photon emission tomography (SPET) (day 27) showed marked left hemispheric hypoperfusion. The patient recovered completely after 40 days and neuroimaging follow-up (MRI and SPET) after six months was normal. The patient carried a missense mutation of the ATP1A2 gene.Conclusion: Multimodal neuroimaging (MRI, DWI, MRS, SPET) in a prolonged HM attack supports evidence for a primary neuronal dysfunction. [ABSTRACT FROM AUTHOR]- Published
- 2011
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- View/download PDF
44. Description and Clinical Signs and Symptoms of the Main Forms of Simple Craniosynostosis
- Author
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Toldo, I. and Drigo, P.
- Abstract
Craniosynostosis, a skull growth disorder due to premature fusion of one or more sutures, is a common clinical problem requiring the attention of many specialists. In simple craniosynostosis (stenosis of a single suture) symptoms are usually mild: signs of intracranial hypertension, mental deficiency, visual or hearing problema are rare, whereas learning disorders or aesthetic and psychological problema are more common. Considering the data in the literature, we analyze the clinical presentation of the main forms of simple craniosynostosis (scaphocephaly, trigonocephaly, brachycephaly, plagiocephaly), their assessment, when measuring intracranial pressure can be useful and whether surgery affects late cognitive outcome.
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- 2005
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45. Operational scenarios simulation to support building design: A hospital design case study
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Simeone, D., Toldo, I., and STEFANO CURSI
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Operational simulation ,hospital design ,Building use simulation ,Virtual environment ,BPMN
46. Plasma exchange in pediatric anti-NMDAR encephalitis: A systematic review.
- Author
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Suppiej, A., Nosadini, M., Zuliani, L., Pelizza, M. F., Toldo, I., Bertossi, C., Tison, T., Zoccarato, M., Marson, P., Giometto, B., Dale, R. C., and Sartori, S.
- Subjects
- *
TREATMENT of encephalitis , *PLASMA exchange (Therapeutics) , *METHYL aspartate receptors , *IMMUNOTHERAPY , *DRUG administration , *SYSTEMATIC reviews - Abstract
OBJECTIVE: To clarify the most frequent modalities of use of plasma exchange (PE) in pediatric anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis and to establish the most effective association with other immunotherapies. METHODS: Systematic literature review on PE in pediatric anti-NMDAR encephalitis (2007-2015). RESULTS: Seventy-one articles were included (mostly retrospective), reporting a total of 242 subjects (73.2%, 93/127 females; median age at onset 12years, range 1-18). Median time to immunotherapy was 21days (range 0-190). In most cases, PE was given with steroids and IVIG (69.5%, 89/128), or steroids only (18%, 23/128); in a minority, it was associated with IVIG only (7%, 9/128), or was the only first-line treatment (5.5%, 7/128). In 54.5% (65/119), PE was the third treatment after steroids and IVIG, in 31.1% (37/119) the second after steroids or IVIG; only in 14.3% (17/119) was it the first treatment. Second-line immunotherapies were administered in 71.9% (100/139). Higher rates of full/substantial recovery at follow-up were observed with immunotherapy given ?30days from onset (69.4%, 25/36) compared to later (59.2%, 16/27), and when PE was associated with steroids (66.7%, 70/105) rather than not (46.7%, 7/15). Significant adverse reactions to PE were reported in 6 patients. CONCLUSION: Our review disclosed a paucity of quality data on PE in pediatric anti-NMDAR encephalitis. PE use in this condition has been increasingly reported, most often with steroids and IVIG. Despite the limited number of patients, our data seem to confirm the trend towards a better outcome when PE was administered early, and when given with steroids. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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47. I stay at home with headache. A survey to investigate how the lockdown for COVID-19 impacted on headache in Italian children
- Author
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Matteo Battisti, Agnese Onofri, Noemi Faedda, Samuela Tarantino, Pierfrancesco Alaimo Di Loro, Paola Verdecchia, Federico Vigevano, Licia Grazzi, Vincenzo Raieli, Vittorio Sciruicchio, Maria Federica Pelizza, Michela An Ferilli, Massimiliano Valeriani, Fabiana Ursitti, Giulia Natalucci, Elisabetta Tozzi, Vincenzo Guidetti, Romina Moavero, Daniela D'Agnano, Margherita Velardi, Giovanni Grillo, Irene Toldo, Angela Celi, Pasquale Parisi, Cristiano Termine, Martina Balestri, Michelangelo Vasta, Marco Carotenuto, Laura Papetti, Papetti, L., Loro, P. A. D., Tarantino, S., Grazzi, L., Guidetti, V., Parisi, P., Raieli, V., Sciruicchio, V., Termine, C., Toldo, I., Tozzi, E., Verdecchia, P., Carotenuto, M., Battisti, M., Celi, A., D'Agnano, D., Faedda, N., Ferilli, M. A. N., Grillo, G., Natalucci, G., Onofri, A., Pelizza, M. F., Ursitti, F., Vasta, M., Velardi, M., Balestri, M., Moavero, R., Vigevano, F., and Valeriani, M.
- Subjects
Male ,Anxiety ,lockdown ,0302 clinical medicine ,COVID-19 ,lifestyle ,migraine ,adolescent ,anxiety ,betacoronavirus ,child ,female ,headache ,humans ,Italy ,male ,SARS-CoV-2 ,social isolation ,surveys and questionnaires ,coronavirus infections ,life style ,pandemics ,pneumonia ,viral ,Surveys and Questionnaires ,Medicine ,Surveys and Questionnaire ,030212 general & internal medicine ,Viral ,Social isolation ,Child ,education.field_of_study ,Headache ,General Medicine ,Settore MED/39 ,pneumonia, viral ,covid-19 ,Social Isolation ,Female ,medicine.symptom ,Coronavirus Infections ,medicine.drug ,Human ,Topiramate ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Population ,Pneumonia, Viral ,03 medical and health sciences ,Betacoronavirus ,Humans ,education ,Psychiatry ,Pandemics ,Life Style ,Migraine ,Special Section Articles ,Betacoronaviru ,Pandemic ,business.industry ,Coronavirus Infection ,Pneumonia ,medicine.disease ,Mood ,Etiology ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective The present Italian multicenter study aimed at investigating whether the course of primary headache disorders in children and adolescents was changed during the lockdown necessary to contain the COVID-19 emergency in Italy. Methods During the lockdown, we submitted an online questionnaire to patients already diagnosed with primary headache disorders. Questions explored the course of headache, daily habits, psychological factors related to COVID-19, general mood and school stress. Answers were transformed into data for statistical analysis. Through a bivariate analysis, the main variables affecting the subjective trend of headache, and intensity and frequency of the attacks were selected. The significant variables were then used for the multivariate analysis. Results We collected the answers of 707 patients. In the multivariate analysis, we found that reduction of school effort and anxiety was the main factor explaining the improvement in the subjective trend of headache and the intensity and frequency of the attacks ( p 0.05), presence of chronic headache disorders ( p > 0.05) and geographical area ( p > 0.05). Conclusions Our study showed that lifestyle modification represents the main factor impacting the course of primary headache disorders in children and adolescents. In particular, reduction in school-related stress during the lockdown was the main factor explaining the general headache improvement in our population.
- Published
- 2020
48. Headache attributed to aeroplane travel: the first multicentric survey in a paediatric population affected by primary headaches
- Author
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Sergio Zanini, Agnese Maria Tamborino, Vittorio Sciruicchio, Barbara Bolzonella, Maria Giuseppina Ledda, Irene Toldo, Pier Antonio Battistella, Stefano Sartori, Vincenzo Raieli, Michela Gatta, Lucia Margari, Alberto Verrotti, A Vecchio, Margherita Santucci, D De Carlo, De Carlo D., Toldo I., Tamborino A.M., Bolzonella B., Ledda M.G., Margari L., Raieli V., Santucci M., Sciruicchio V., Vecchio A., Zanini S., Sartori S., Gatta M., Verrotti A., and Battistella P.A.
- Subjects
Male ,Pediatrics ,Neurology ,Photophobia ,Aircraft ,Headache Disorder ,lcsh:Medicine ,Airplane ,0302 clinical medicine ,Surveys and Questionnaires ,Surveys and Questionnaire ,030212 general & internal medicine ,Child ,Children ,Aeroplane travel ,Pain Measurement ,Travel ,ICHD-III ,Headache ,General Medicine ,Pediatric headache ,Phonophobia ,Italy ,Child, Preschool ,Female ,medicine.symptom ,Research Article ,Human ,Adult ,medicine.medical_specialty ,Adolescent ,Headache Disorders ,03 medical and health sciences ,Primary headache ,Primary headaches ,medicine ,Humans ,Preschool ,business.industry ,lcsh:R ,Mean age ,Anesthesiology and Pain Medicine ,Concomitant ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Paediatric population - Abstract
BACKGROUND: This multicentric survey investigates the prevalence and characteristics of Airplane Headache in children affected by primary headaches. METHODS: Patients with symptoms of Airplane Headache were recruited from nine Italian Pediatric Headache Centres. Each patient was handed a structured questionnaire which met the ICHD-III criteria. RESULTS: Among 320 children suffering from primary headaches who had flights during their lifetime, 15 (4.7%) had Airplane Headache, with mean age of 12.4years. Most of the patients were females (80%). The headache was predominantly bilateral (80%) and localized to the frontal area (60%); it was mainly pulsating, and lasted less than 30min in all cases. Accompanying symptoms were tearing, photophobia, phonophobia in most of the cases (73.3%). More than 30% of patients used medications to treat the attacks, with good results. CONCLUSION: Our study shows that Airplane Headache is not a rare disorder in children affected by primary headaches and highlights that its features in children are peculiar and differ from those described in adults. In children Airplane Headache prevails in females, is more often bilateral, has frequently accompanying symptoms and occurs at any time during the flight. Further studies are needed to confirm the actual frequency of Airplane Headache in the general pediatric population not selected from specialized Headache Centres, with and without other concomitant headache condition, and to better clarify the clinical characteristics, pathophysiology and potential therapies.
- Published
- 2018
49. Cranial Nerve Abnormalities in Oculo-Auriculo-Vertebral Spectrum
- Author
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Giovanni Schifano, Roberto Bovo, Elena Cantone, Sara Ghiselli, Davide Brotto, Irene Toldo, Alessandro Martini, Renzo Manara, Rodica Mardari, Manara, R, Brotto, D, Ghiselli, S, Mardari, R, Toldo, I, Schifano, G, Cantone, E, Bovo, Ylenia, and Martini, A
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Goldenhar syndrome ,Inferior alveolar nerve ,Cranial Nerve ,Pediatrics ,Young Adult ,Goldenhar Syndrome ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Diplopia ,business.industry ,Microtia ,Cranial nerves ,Cranial Nerves ,Infant, Newborn ,Infant ,Aplasia ,Anatomy ,medicine.disease ,Magnetic Resonance Imaging ,Facial nerve ,Hemifacial microsomia ,Phenotype ,Child, Preschool ,Female ,Neurology (clinical) ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Human - Abstract
BACKGROUND AND PURPOSE: Cranial nerve abnormalities might be observed in hemifacial microsomia and microtia (oculo-auriculo-vertebral spectrum), but the rate, features, and relationship with functional impairment or phenotype severity have not yet been defined. This study aimed at investigating absence/asymmetry, abnormal origin, morphology and course of cranial nerves, and presence/asymmetry of the foramen ovale and inferior alveolar nerve canal in a cohort of oculo-auriculo-vertebral spectrum patients. MATERIALS AND METHODS: Twenty-nine patients with oculo-auriculo-vertebral spectrum (mean age, 7 years; age range, 0.2–31 years; 12 females) underwent brain MR imaging, CT, and neurologic evaluation; 19 patients had a more severe phenotype (Goldenhar syndrome). RESULTS: Cranial nerve abnormalities were detected only in patients with Goldenhar syndrome (17/19, bilaterally in 8) and were involved the second (4/19), third (1/18), fifth (11/19), sixth (8/16), seventh (11/18), and eighth (8/18) cranial nerves. Multiple cranial nerve abnormalities were common (11/17). Eleven patients showed bone foramina abnormalities. Trigeminal and facial nerve dysfunctions were common (44% and 58%, respectively), especially in patients with Goldenhar syndrome. Trigeminal abnormalities showed a good correlation with ipsilateral dysfunction (P = .018), which further increased when bone foramina abnormalities were included. The facial nerve showed a trend toward correlation with ipsilateral dysfunction (P = .081). Diplopia was found only in patients with Goldenhar syndrome and was associated with third and sixth cranial nerve abnormalities (P = .006). CONCLUSIONS: Among patients with oculo-auriculo-vertebral spectrum, cranial nerve morphologic abnormalities are common, correlate with phenotype severity, and often entail a functional impairment. The spectrum of cranial nerve abnormalities appears wider than simple hypo-/aplasia and includes an anomalous cisternal course and partial/complete fusion of diverse cranial nerves.
- Published
- 2015
50. Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication
- Author
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Ve E. Rinaldi, Giangennaro Coppola, M. Rauchenzauner, Salvatore Savasta, Renata Rizzo, Pasquale Parisi, L. Giordano, Francesca Ragona, Lucia Margari, R. Gaggero, G.L. Marseglia, Pasquale Striano, Giuseppe Capovilla, G. Di Gennaro, Daniela Laino, Vincenzo Belcastro, Alberto Spalice, Maria Esposito, Salvatore Grosso, Francesca Felicia Operto, Nelia Zamponi, Piero Pavone, S. Siliquini, Raffaella Cusmai, Agnese Suppiej, Alberto Verrotti, Irene Toldo, Sara Matricardi, Caterina Cerminara, Verrotti, A, Laino, D., Rinaldi, V. E., Suppiej, A., Giordano, L., Toldo, I., Margari, L., Parisi, P., Rizzo, R., Matricardi, S., Cusmai, R., Grosso, S., Gaggero, R., Zamponi, N., Pavone, P., Capovilla, G., Rauchenzauner, M., Cerminara, C., Di Gennaro, G., Esposito, Maria, Striano, P., Savasta, S., Coppola, G., Siliquini, S., Operto, F., Belcastro, V., Ragona, F., Marseglia, G. L., and Spalice, A.
- Subjects
Male ,Pediatrics ,Neurology ,Epilepsy ,0302 clinical medicine ,Retrospective Studie ,Outcome Assessment, Health Care ,Anticonvulsant ,EEG ,Family history ,Child ,Outcome ,Generalized epilepsy ,antiepileptic therapy ,focal epilepsy ,Focal epilepsy ,Electroencephalography ,Prognosis ,Austria ,Child, Preschool ,Anticonvulsants ,Female ,Occipital Lobe ,Antiepileptic therapy ,Idiopathic occipital epilepsy ,Human ,Adult ,medicine.medical_specialty ,Adolescent ,Prognosi ,Humans ,Infant ,Retrospective Studies ,Young Adult ,Lennox Gastaut Syndrome ,Outcome Assessment (Health Care) ,Neurology (clinical) ,NO ,03 medical and health sciences ,030225 pediatrics ,medicine ,Preschool ,business.industry ,Retrospective cohort study ,medicine.disease ,eeg ,generalized epilepsy ,idiopathic occipital epilepsy ,outcome ,Migraine ,business ,Occipital lobe ,030217 neurology & neurosurgery ,Lennox–Gastaut syndrome - Abstract
Background and purpose: Our aim was to describe the clinical and electrical features and the long-term evolution of childhood occipital epilepsy of Gastaut (COE-G) in a cohort of patients and to compare long-term prognosis between patients with and without other epileptic syndromes. Methods: This was a retrospective analysis of the long-term outcome of epilepsy in 129 patients with COE-G who were referred to 23 Italian epilepsy centres and one in Austria between 1991 and 2004. Patients were evaluated clinically and with electroencephalograms for 10.1-23.0 years. The following clinical characteristics were evaluated: gender, patient age at seizure onset, history of febrile seizures and migraine, family history of epilepsy, duration and seizure manifestations, circadian distribution and frequency of seizures, history of medications including the number of drugs, therapeutic response and final outcome. Results: Visual hallucinations were the first symptom in 62% and the only manifestation in 38.8% of patients. Patients were subdivided into two groups: group A with isolated COE-G; group B with other epileptic syndromes associated with COE-G. The most significant (P < 0.05) difference concerned antiepileptic therapy: in group A, 45 children responded to monotherapy; in group B only 15 children responded to monotherapy. At the end of follow-up, the percentage of seizure-free patients was significantly higher in group A than in group B. Conclusions: Childhood occipital epilepsy of Gastaut has an overall favourable prognosis and a good response to antiepileptic therapy with resolution of seizures and of electroencephalogram abnormalities. The association of typical COE-G symptoms with other types of seizure could be related to a poor epilepsy outcome.
- Published
- 2016
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