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20. Chemically Modified Chitosans

Author

Muzzarelli, A. A., Agrawal, O. P., Casu, B., Colombo, M., Compagnoni, T., Domard, A., Domszy, J. C., Ebina, A., Focher, B., Fuji-i, K., Gadelle, A., Gervasini, A., Hirano, S., Kondo, Y., Konrad, E., Lang, G., Maekita, Y., Massoli, A., Morazzoni, F., Naggi, A., Nishi, A., Nishimura, S., Pivari, E., Rinaudo, M., Roberts, G. A. F., Scheller, K., Tokura, S., Torri, G., Tsutsumi, A., Wendel, H., Wood, F. A., Muzzarelli, Riccardo, editor, Jeuniaux, Charles, editor, and Gooday, Graham W., editor

Published
1986
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21. Visualization of magnetic microparticles in liquid and control of their motion using dynamic magnetic field

Author

Tokura, S., Hara, M., Kawaguchi, N., Izawa, J., and Amemiya, N.

Subjects
Fluid dynamics -- Analysis, Magnetic fields -- Analysis, Physics
Abstract

The significance of the visualization technique in for analyzing the motion and its control via dynamic magnetic field in magnetic microparticles in liquid is demonstrated. A new system for the visualization of micron-size particles is also presented.

Published
2010

23. Preparation of doxorubicin-containing chitosan microspheres for transcatheter arterial chemoembolization of hepatocellular carcinoma

Author

Kim Yb, Han Sm, Son Sh, Kim Js, Byung Kook Kwak, Hyung Jin Shim, Tokura S, Lee Bm, Lee Yc, Myoung-Jae Lee, and Baik Hw

Subjects
Male, medicine.medical_specialty, Chemical Phenomena, medicine.medical_treatment, Pharmaceutical Science, Bioengineering, Chitosan, chemistry.chemical_compound, Freeze-drying, Liver Neoplasms, Experimental, Colloid and Surface Chemistry, health services administration, Animals, Medicine, Doxorubicin, Embolization, Chemoembolization, Therapeutic, Physical and Theoretical Chemistry, Microparticle, Transcatheter arterial chemoembolization, health care economics and organizations, Antibiotics, Antineoplastic, Chemistry, Physical, business.industry, Organic Chemistry, medicine.disease, Microspheres, Surgery, Freeze Drying, Treatment Outcome, chemistry, Delayed-Action Preparations, Hepatocellular carcinoma, Microscopy, Electron, Scanning, Doxorubicin Hydrochloride, Rabbits, Tomography, X-Ray Computed, Nuclear medicine, business, medicine.drug
Abstract

A new form of doxorubicin hydrochloride (DRH)-containing chitosan microspheres (CMs) was prepared by employing an expanding-loading-shrinking (E-L-S) process. One hundred mg of pre-formed CMs were soaked in absolute ethanol and then placed in reduced pressure (the expanding process). Ten mg of DRH (2 mg ml(-1)) were added into the expanded CMs (the loading process). Next the microspheres were freeze-dried (the shrinking process). As a result of this E-L-S process, 10% (w/w) DRH-containing CMs (DRH-CM) were made. During 7 days, 22.6% of the DRH was observed to be released on the in vitro drug release study. In addition, these new DRH-CMs could be used for transcatheter arterial chemoembolization (TACE) procedure in VX2 hepatic tumour models of rabbit and the anti-tumour effects of DRH-CMs were investigated. On the post-CT scan 7 days after the TACE, total infarctions of the VX2 tumour were observed in 5 rabbits among the 6 total rabbits.

Published
2007

26. Visualization of magnetic microparticles in liquid and control of their motion using dynamic magnetic field

Author

10222697, Tokura, S., Hara, M., Kawaguchi, N., Izawa, J., Amemiya, N., 10222697, Tokura, S., Hara, M., Kawaguchi, N., Izawa, J., and Amemiya, N.

Abstract

Visualization technique of micro- or nanoparticles with sufficient spatial and temporal resolutions is required for quantitative study of motion of magnetic particles and their control using a dynamic magnetic field. Based on the particle tracking velocimetry method, a visualization system of micron-size particles has been developed. A proof-of-concept experiment of controlling magnetic particles using a dynamic magnetic field was made, and motions of magnetic particles under a dynamic magnetic field were visualized successfully using the developed system: the motions of particles synchronizing with the applied dynamic magnetic field could be observed.

Published
2010

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