101 results on '"Tok, S"'
Search Results
2. Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease
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Tok, S., Maurin, H., Delay, C., Crauwels, D., Manyakov, N. V., Van Der Elst, W., Moechars, D., and Drinkenburg, W. H. I. M.
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- 2022
- Full Text
- View/download PDF
3. Additional file 1 of Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease
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Tok, S., Maurin, H., Delay, C., Crauwels, D., Manyakov, N. V., Van Der Elst, W., Moechars, D., and Drinkenburg, W. H. I. M.
- Abstract
Additional file 1. Supplementary document containing additional information on the Methods, Non-identifiable patient characteristics, Quality control data, as well as non-significant findings.
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- 2022
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4. Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer's disease
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Tok, S., Maurin, H., Delay, C., Crauwels, D., Manyakov, N. V., Van Der Elst, W., Moechars, D., Drinkenburg, W. H. I. M., Kas lab, and Neurobiology
- Subjects
Multidisciplinary ,Amyloid beta-Peptides ,Amyloidogenic Proteins ,Mice, Transgenic ,Neurodegenerative Diseases ,Plaque, Amyloid ,tau Proteins ,Amyloidosis ,Amyloid beta-Protein Precursor ,Disease Models, Animal ,Mice ,Alzheimer Disease ,mental disorders ,Presenilin-1 ,Animals ,Humans - Abstract
Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by two main pathological hallmarks: amyloid plaques and intracellular tau neurofibrillary tangles. However, a majority of studies focus on the individual pathologies and seldom on the interaction between the two pathologies. Herein, we present the longitudinal neuropathological and neurophysiological effects of a combined amyloid-tau model by hippocampal seeding of human-derived tau pathology in the APP.PS1/L166P amyloid animal model. We statistically assessed both neurophysiological and pathological changes using linear mixed modelling to determine if factors such as the age at which animals were seeded, genotype, seeding or buffer, brain region where pathology was quantified, and time-post injection differentially affect these outcomes. We report that AT8-positive tau pathology progressively develops and is facilitated by the amount of amyloid pathology present at the time of injection. The amount of AT8-positive tau pathology was influenced by the interaction of age at which the animal was injected, genotype, and time after injection. Baseline pathology-related power spectra and Higuchi Fractal Dimension (HFD) score alterations were noted in APP.PS1/L166P before any manipulations were performed, indicating a baseline difference associated with genotype. We also report immediate localized hippocampal dysfunction in the electroencephalography (EEG) power spectra associated with tau seeding which returned to comparable levels at 1 month-post-injection. Longitudinal effects of seeding indicated that tau-seeded wild-type mice showed an increase in gamma power earlier than buffer control comparisons which was influenced by the age at which the animal was injected. A reduction of hippocampal broadband power spectra was noted in tau-seeded wild-type mice, but absent in APP.PS1 animals. HFD scores appeared to detect subtle effects associated with tau seeding in APP.PS1 animals, which was differentially influenced by genotype. Notably, while tau histopathological changes were present, a lack of overt longitudinal electrophysiological alterations was noted, particularly in APP.PS1 animals that feature both pathologies after seeding, reiterating and underscoring the difficulty and complexity associated with elucidating physiologically relevant and translatable biomarkers of Alzheimer’s Disease at the early stages of the disease.
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- 2021
5. Spinal Cord Tumors, Biology of
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Tok, S., primary, Hadelsberg, U., additional, and Jallo, G.I., additional
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- 2014
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6. The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015-2016
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Russell, CJ, Suttie, A, Tok, S, Yann, S, Keo, P, Horm, SV, Roe, M, Kaye, M, Sorn, S, Holl, D, Tum, S, Barr, IG, Hurt, AC, Greenhill, AR, Karlsson, EA, Vijaykrishna, D, Deng, Y-M, Dussart, P, Horwood, PF, Russell, CJ, Suttie, A, Tok, S, Yann, S, Keo, P, Horm, SV, Roe, M, Kaye, M, Sorn, S, Holl, D, Tum, S, Barr, IG, Hurt, AC, Greenhill, AR, Karlsson, EA, Vijaykrishna, D, Deng, Y-M, Dussart, P, and Horwood, PF
- Abstract
Low pathogenic A(H9N2) subtype avian influenza viruses (AIVs) were originally detected in Cambodian poultry in 2013, and now circulate endemically. We sequenced and characterised 64 A(H9N2) AIVs detected in Cambodian poultry (chickens and ducks) from January 2015 to May 2016. All A(H9) viruses collected in 2015 and 2016 belonged to a new BJ/94-like h9-4.2.5 sub-lineage that emerged in the region during or after 2013, and was distinct to previously detected Cambodian viruses. Overall, there was a reduction of genetic diversity of H9N2 since 2013, however two genotypes were detected in circulation, P and V, with extensive reassortment between the viruses. Phylogenetic analysis showed a close relationship between A(H9N2) AIVs detected in Cambodian and Vietnamese poultry, highlighting cross-border trade/movement of live, domestic poultry between the countries. Wild birds may also play a role in A(H9N2) transmission in the region. Some genes of the Cambodian isolates frequently clustered with zoonotic A(H7N9), A(H9N2) and A(H10N8) viruses, suggesting a common ecology. Molecular analysis showed 100% of viruses contained the hemagglutinin (HA) Q226L substitution, which favours mammalian receptor type binding. All viruses were susceptible to the neuraminidase inhibitor antivirals; however, 41% contained the matrix (M2) S31N substitution associated with resistance to adamantanes. Overall, Cambodian A(H9N2) viruses possessed factors known to increase zoonotic potential, and therefore their evolution should be continually monitored.
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- 2019
7. Ciprofloxacin-induced cutaneous vasculitis
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Lieu, P. K., Tok, S. C., Ismail, N. H., and Chng, H. H.
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- 1997
8. The effect of anatomic differences on the relationship between renal artery and diaphragmatic crus
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Esen, K., primary, Tok, S., additional, Balci, Yuksel, additional, Apaydin, F. D., additional, Kara, E., additional, and Uzmansel, D., additional
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- 2018
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9. Colliding Nationalisms: Interstate Relations in Asia
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Wang, L, Zhao, J, Tok, S, Wang, L, Zhao, J, and Tok, S
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- 2017
10. A critical period for antidepressant-induced acceleration of neuronal maturation in adult dentate gyrus
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Åmellem, I, primary, Suresh, S, additional, Chang, C C, additional, Tok, S S L, additional, and Tashiro, A, additional
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- 2017
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11. Searches for B-(s)(0) -> J/psi p(p)over-bar and B+ -> J/psi p(p)over-bar pi(+) decays
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Aaij, R, Adeva, B, Adinolfi, M, Adrover, C, Affolder, A, Ajaltouni, Z, Albrecht, J, Alessio, F, Alexander, M, Ali, S, Alkhazov, G, Alvarez Cartelle, P, Jr, AAA, Amato, S, Amerio, S, Amhis, Y, Anderlini, L, Anderson, J, Andreassen, R, Andrews, JE, Appleby, RB, Gutierrez, OA, Archilli, F, Artamonov, A, Artuso, M, Aslanides, E, Auriemmam, G, Baalouch, M, Bachmann, S, Back, JJ, Baesso, C, Balagura, V, Baldini, W, Barlow, RJ, Barsche, C, Barsuk, S, Barter, W, Bauer, T, Bay, A, Beddow, J, Bedeschi, F, Bediagal, I, Belogurov, S, Belous, K, Belyaev, I, Ben-Haim, E, Bencivenni, G, Benson, S, Benton, J, Berezhnoy, A, Bernet, R, Bettler, M-O, van Beuzekom, M, Bien, A, Bifani, S, Bird, T, Bizzeti, A, Bjornstad, PM, Blake, T, Blanc, F, Blouw, J, Blusk, S, Bocci, V, Bondar, A, Bondar, N, Bonivento, W, Borghi, S, Borgia, A, Bowcock, TJV, Bowen, E, Bozzi, C, Brambach, T, van den Brand, J, Bressieux, J, Brett, D, Britschl, M, Britton, T, Brook, NH, Brown, H, Burducea, I, Bursche, A, Busettoq, G, Buytaert, J, Cadeddu, S, Callot, O, Calvi, M, Calvo Gomez, M, Camboni, A, Campana, P, Perez, DC, Carbone, A, Carboni, G, Cardinale, R, Cardini, A, Carranza-Mejia, H, Carson, L, Carvalho Akiba, K, Casse, G, Garcia, LC, Cattaneo, M, Cauet, C, Cenci, R, Charles, M, Charpentier, P, Chen, P, Chiapolini, N, Chrzaszcz, M, Ciba, K, Vida, XC, Ciezarek, G, Clarke, PEL, Clemencic, M, Cliff, HV, Closier, J, Coca, C, Coco, V, Cogan, J, Cogneras, E, Collins, P, Comerma-Montells, A, Contu, A, Cook, A, Coombes, M, Coquereau, S, Corti, G, Couturier, B, Cowan, GA, Craik, DC, Cunliffe, S, Currie, R, D'Ambrosio, C, David, P, David, PNY, Davis, A, De Bonis, I, De Bruyn, K, De Capua, S, De Cian, M, De Mirandal, JM, De Paula, L, De Silva, W, De Simone, P, Decamp, D, Deckenhoff, M, Del Buono, L, Deleage, N, Derkach, D, Deschamps, O, Dettori, F, Di Canton, A, Di Ruscio, F, Dijkstra, H, Dogaru, M, Donleavy, S, Dordeill, F, Dosil Suarez, A, Dossett, D, Dovbnya, A, Dupertuis, F, Durante, P, Dzhelyadin, R, Dziurda, A, Dzyuba, A, Easo, S, Egede, U, Egorychev, V, Eidelman, S, van Eijk, D, Eisenhardt, S, Eitschberger, U, Ekelhof, R, Eklund, L, El Rifai, I, Elsasser, C, Falabellae, A, Farber, C, Fardell, G, Farinelli, C, Farry, S, Fave, V, Ferguson, D, Fernandez Albor, V, Ferreira Rodrigues, F, Ferro-Luzzi, M, Filippov, S, Fiore, M, Fitzpatrick, C, Fontana, M, Fontanelli, F, Forty, R, Francisco, O, Frank, M, Frei, C, Frosini, M, Furcas, S, Furfaro, E, Gallas Torreira, A, Galli, D, Gandelman, M, Gandini, P, Gao, Y, Garofoli, J, Garosi, P, Tico, JG, Garrido, L, Gaspar, C, Gauld, R, Gersabeck, E, Gersabeck, M, Gershon, T, Ghez, P, Gibson, V, Giubega, L, Gligorov, VV, Goebel, C, Golubkov, D, Golutvin, A, Gomes, A, Gordon, H, Gandara, MG, Graciani Diaz, R, Cardoso, LAG, Grauges, E, Graziani, G, Grecu, A, Greening, E, Gregson, S, Griffith, P, Gruenberg, O, Gui, B, Gushchin, E, Guz, Y, Gys, T, Hadjivasiliou, C, Haefeli, G, Haen, C, Haines, SC, Hal, S, Hamilton, B, Hampson, T, Hansmann-Menzemer, S, Harnew, N, Harnew, ST, Harrison, J, Hartmann, T, He, J, Head, T, Heijne, V, Hennessy, K, Henrard, P, Hernando Morata, JA, van Herwijnen, E, Hicheurl, A, Hicks, E, Hill, D, Hoballah, M, Holtrop, M, Hombach, C, Hopchev, P, Hulsbergen, W, Hunt, P, Huse, T, Hussain, N, Hutchcroft, D, Hynds, D, Iakovenko, V, Idzik, M, Ilten, P, Jacobsson, R, Jaeger, A, Jans, E, Jaton, P, Jawahery, A, Jing, F, John, M, Johnson, D, Jones, CR, Joram, C, Jost, B, Kaballo, M, Kandybei, S, Kanso, W, Karacson, M, Karbach, TM, Kenyon, IR, Kete, T, Keune, A, Khanji, B, Kochebina, O, Komarov, I, Koopman, RF, Koppenbure, P, Korolev, M, Kozlinskiy, A, Kravchuk, L, Krepin, K, Kreps, M, Krocker, G, Krokovny, P, Kruse, F, Kucharczyk, M, Kudryavtsev, V, Kvaratskheliya, T, La Thi, VN, Lacarrere, D, Lafferty, G, Lai, A, Lambert, D, Lambert, RW, Lanciotti, E, Lanfranchi, G, Langenbruch, C, Latham, T, Lazzeroni, C, Le Gac, R, van Leerdam, J, Lees, J-P, Leievre, R, Leflat, A, Lefrancois, J, Leo, S, Leroy, O, Lesiak, T, Leverington, B, Li, Y, Li Gioi, L, Liles, M, Lindner, R, Linn, C, Liu, B, Liu, G, Lohn, S, Longstaff, I, Lopes, JH, Lopez-March, N, Lu, H, Lucchesi, D, Luisier, J, Luo, H, Machefert, F, Machikhiliyan, IV, Maciuc, F, Maev, O, Malde, S, Manca, G, Mancinelli, G, Maratas, J, Marconi, U, Marino, P, Marki, R, Marks, J, Martellotti, G, Martens, A, Sanchez, AM, Martinelli, M, Santos, DM, Martins Tostes, D, Massafferri, A, Matev, R, Mathe, Z, Matteuzzi, C, Maurice, E, Mazurov, A, Mc Skelly, B, McCarthy, J, McNab, A, McNulty, R, Meadows, B, Meier, F, Meissner, M, Merk, M, Milanes, DA, Minard, M-N, Rodriguez, JM, Montei, S, Moran, D, Morawski, P, Morda, A, Morello, MJ, Mountain, R, Mous, I, Muheim, F, Mueller, K, Muresan, R, Muryn, B, Muster, B, Naik, P, Nakada, T, Nandakumar, R, Nasteval, I, Needham, M, Neubert, S, Neufeld, N, Nguyen, AD, Nguyen, TD, Nguyen-Mau, C, Nicol, M, Niess, V, Niet, R, Nikitin, N, Nikodem, T, Nomerotski, A, Novoselov, A, Oblakowska-Mucha, A, Obraztsov, V, Oggero, S, Ogilvy, S, Okhrimenko, O, Odeman, R, Orlandea, M, Otalora Goicochea, JM, Owen, P, Oyanguren, A, Pal, BK, Palano, A, Palutan, M, Panman, J, Papanestis, A, Pappagallo, M, Parkes, C, Parkinson, CJ, Passaleva, G, Patel, GD, Patel, M, Patrick, GN, Patrignani, C, Pavel-Nicorescu, C, Pazos Alvarez, A, Pellegrino, A, Penso, G, Altarelli, MP, Perazzini, S, Perez Trigo, E, Perez-Calero Yzquierdo, A, Perret, P, Perrin-Terrin, M, Pescatore, L, Pessina, G, Petridis, K, Petrolini, A, Phan, A, Picatoste Olloqui, E, Pietrzyk, B, Pilar, T, Pinci, D, Playfer, S, Plo Casasus, M, Polci, F, Polok, G, Poluektov, A, Polycarpo, E, Popov, A, Popov, D, Popovici, B, Potterat, C, Powell, A, Prisciandaro, J, Pritchard, A, Prouve, C, Pugatch, V, Navarro, AP, Punzi, G, Qian, W, Rademacker, JH, Rakotomiaramanana, B, Rangel, MS, Raniuk, I, Rauschmayr, N, Raven, G, Redford, S, Reid, MM, dos Reis, AC, Ricciardi, S, Richards, A, Rinnert, K, Rives Molina, V, Romero, DAR, Robbe, P, Roberts, DA, Rodrigues, E, Rodriguez Perez, P, Roiser, S, Romanovsky, V, Romero Vidal, A, Rouvinet, J, Ruf, T, Ruffini, F, Ruiz, H, Ruiz Valls, P, Sabatino, G, Saborido Silva, JJ, Sagidova, N, Sail, P, Saitta, B, Salustino Guimaraes, V, Salzmann, C, Sanmartin Sedes, B, Sannino, M, Santacesaria, R, Santamarina Rios, C, Santovetti, E, Sapunov, M, Sarti, A, Satriano, C, Satta, A, Savrie, M, Savrina, D, Schaack, P, Schiller, M, Schindler, H, Schlupp, M, Schmelling, M, Schmidt, B, Schneider, O, Schopper, A, Schune, M-H, Schwemmer, R, Sciascia, B, Sciubba, A, Seco, M, Semennikov, A, Sepp, I, Serra, N, Serrano, J, Seyfert, P, Shapkin, M, Shapoval, I, Shatalov, P, Shcheglov, Y, Shears, T, Shekhtman, L, Shevchenko, O, Shevchenko, V, Shires, A, Coutinho, RS, Sirendi, M, Skwarnicki, T, Smith, NA, Smith, E, Smith, J, Smith, M, Sokoloff, MD, Soler, FJP, Soomro, F, Souza, D, Souza De Paula, B, Spam, B, Sparkes, A, Spradlin, P, Stagni, F, Stahl, S, Steinkamp, O, Stoica, S, Stone, S, Storaci, B, Straticiuc, M, Straumann, U, Subbiah, VK, Sun, L, Swientek, S, Syropoulos, V, Szczekowski, M, Szczypka, P, Szumlak, T, T'Jampens, S, Teklishyn, M, Teodorescu, E, Teubert, F, Thomas, C, Thomas, E, van Tilburg, J, Tisserand, V, Tobin, M, Tok, S, Tonelli, D, Topp-Joergensen, S, Torr, N, Tournefier, E, Tourneur, S, Tran, MT, Tresch, M, Tsaregorodtsev, A, Tsopelas, P, Tuning, N, Garcia, MU, Ukleja, A, Urner, D, Ustyuzhanin, A, Uwer, U, Vagnoni, V, Valenti, G, Vallier, A, Van Dijk, M, Gomez, RV, Vazquez Regueiro, P, Vazquez Sierra, C, Vecchi, S, Velthuis, JJ, Veltri, M, Veneziano, G, Vesterinen, M, Viaud, B, Vieira, D, Vilasis-Cardona, X, Vollhardt, A, Volyanskyy, D, Voong, D, Vorobyev, A, Vorobyev, V, Voss, C, Voss, H, Waldi, R, Wallace, C, Wallace, R, Wandernoth, S, Wang, J, Ward, DR, Watson, NK, Webber, AD, Websdale, D, Whitehead, M, Wicht, J, Wiechczynski, J, Wiedner, D, Wiggers, L, Wilkinson, G, Williams, MP, Williams, M, Wilson, FF, Wimberley, J, Wishahi, J, Witek, M, Wotton, SA, Wright, S, Wu, S, Wyllie, K, Xie, Y, Xing, Z, Yang, Z, Young, R, Yuan, X, Yushchenko, O, Zangoli, M, Zavertyaev, M, Zhang, F, Zhang, L, Zhang, WC, Zhang, Y, Zhelezov, A, Zhokhov, A, Zhong, L, Zvyagin, A, Collaboration, L, R., Aaij, B., Adeva, M., Adinolfi, C., Adrover, A., Affolder, Z., Ajaltouni, J., Albrecht, F., Alessio, M., Alexander, S., Ali, G., Alkhazov, P. A., Cartelle, A. A., Alve, S., Amato, S., Amerio, Y., Amhi, L., Anderlini, J., Anderson, R., Andreassen, J. E., Andrew, R. B., Appleby, O. A., Gutierrez, F., Archilli, A., Artamonov, M., Artuso, E., Aslanide, G., Auriemmam, M., Baalouch, S., Bachmann, J. J., Back, C., Baesso, V., Balagura, W., Baldini, R. J., Barlow, C., Barsche, S., Barsuk, W., Barter, T., Bauer, A., Bay, J., Beddow, F., Bedeschi, I., Bediagal, S., Belogurov, K., Belou, I., Belyaev, E., Ben Haim, G., Bencivenni, S., Benson, J., Benton, A., Berezhnoy, R., Bernet, M. O., Bettler, M. v., Beuzekom, A., Bien, S., Bifani, T., Bird, A., Bizzeti, P. M., Bjornstad, T., Blake, F., Blanc, J., Blouw, S., Blusk, V., Bocci, A., Bondar, N., Bondar, W., Bonivento, S., Borghi, A., Borgia, T. J., V., E., Bowen, C., Bozzi, T., Brambach, J. v., Den, J., Bressieux, D., Brett, M., Britschl, T., Britton, N. H., Brook, H., Brown, I., Burducea, A., Bursche, G., Busettoq, J., Buytaert, S., Cadeddu, O., Callot, M., Calvi, M. C., Gomez, A., Camboni, P., Campana, D. C., Perez, A., Carbone, G., Carboni, R., Cardinale, A., Cardini, H., Carranza Mejia, L., Carson, K. C., Akiba, G., Casse, L. C., Garcia, M., Cattaneo, C., Cauet, R., Cenci, M., Charle, P., Charpentier, P., Chen, N., Chiapolini, M., Chrzaszcz, K., Ciba, X. C., Vida, G., Ciezarek, P. E., L., M., Clemencic, H. V., Cliff, J., Closier, C., Coca, V., Coco, J., Cogan, E., Cognera, P., Collin, A., Comerma Montell, A., Contu, A., Cook, M., Coombe, S., Coquereau, G., Corti, B., Couturier, G. A., Cowan, D. C., Craik, S., Cunliffe, R., Currie, C., D'Ambrosio, P., David, P. N., Y., A., Davi, I. D., Boni, K. D., Bruyn, S. D., Capua, M. D., Cian, J. M., De, L. D., Paula, W. D., Silva, P. D., Simone, D., Decamp, M., Deckenhoff, L. D., Buono, N., Deleage, D., Derkach, O., Deschamp, F., Dettori, A. D., Canton, F. D., Ruscio, H., Dijkstra, M., Dogaru, S., Donleavy, F., Dordeill, A. D., Suarez, D., Dossett, A., Dovbnya, F., Dupertui, P., Durante, R., Dzhelyadin, A., Dziurda, A., Dzyuba, S., Easo, U., Egede, V., Egorychev, S., Eidelman, D. v., Eijk, S., Eisenhardt, U., Eitschberger, R., Ekelhof, L., Eklund, I. E., Rifai, C., Elsasser, A., Falabellae, C., Farber, G., Fardell, C., Farinelli, S., Farry, V., Fave, D., Ferguson, V. F., Albor, F. F., Rodrigue, M., Ferro Luzzi, S., Filippov, M., Fiore, C., Fitzpatrick, M., Fontana, F., Fontanelli, R., Forty, O., Francisco, M., Frank, C., Frei, M., Frosini, S., Furca, E., Furfaro, A. G., Torreira, D., Galli, M., Gandelman, P., Gandini, Y., Gao, J., Garofoli, P., Garosi, J. G., Tico, L., Garrido, C., Gaspar, R., Gauld, E., Gersabeck, M., Gersabeck, T., Gershon, P., Ghez, V., Gibson, L., Giubega, V. V., Gligorov, C., Gobel, D., Golubkov, A., Golutvin, A., Gome, H., Gordon, M. G., Gandara, R. G., Diaz, L. A., G., E., Grauge, G., Graziani, A., Grecu, E., Greening, S., Gregson, P., Griffith, O., Grunberg, B., Gui, E., Gushchin, Y., Guz, T., Gy, C., Hadjivasiliou, G., Haefeli, C., Haen, S. C., Haine, S., Hal, B., Hamilton, T., Hampson, S., Hansmann Menzemer, N., Harnew, S. T., Harnew, J., Harrison, T., Hartmann, J., He, T., Head, V., Heijne, K., Hennessy, P., Henrard, J. A., H., E. v., Herwijnen, A., Hicheurl, E., Hick, D., Hill, M., Hoballah, M., Holtrop, C., Hombach, P., Hopchev, W., Hulsbergen, P., Hunt, T., Huse, N., Hussain, D., Hutchcroft, D., Hynd, V., Iakovenko, M., Idzik, P., Ilten, R., Jacobsson, A., Jaeger, E., Jan, P., Jaton, A., Jawahery, F., Jing, M., John, D., Johnson, C. R., Jone, C., Joram, B., Jost, M., Kaballo, S., Kandybei, W., Kanso, M., Karacson, T. M., Karbach, I. R., Kenyon, T., Kete, A., Keune, B., Khanji, O., Kochebina, I., Komarov, R. F., Koopman, P., Koppenbure, M., Korolev, A., Kozlinskiy, L., Kravchuk, K., Krepin, M., Krep, G., Krocker, P., Krokovny, F., Kruse, M., Kucharczyk, V., Kudryavtsev, T., Kvaratskheliya, V. N., La, D., Lacarrere, G., Lafferty, A., Lai, D., Lambert, R. W., Lambert, E., Lanciotti, G., Lanfranchi, C., Langenbruch, T., Latham, C., Lazzeroni, R. L., Gac, J. v., Leerdam, J. P., Lee, R., Leievre, A., Leflat, J., Lefrancoi, S., Leo, O., Leroy, T., Lesiak, B., Leverington, Y., Li, L. L., Gioi, M., Lile, R., Lindner, C., Linn, B., Liu, G., Liu, S., Lohn, I., Longstaff, J. H., Lope, N., Lopez March, H., Lu, D., Lucchesi, J., Luisier, H., Luo, F., Machefert, I. V., Machikhiliyan, F., Maciuc, O., Maev, S., Malde, G., Manca, G., Mancinelli, J., Marata, U., Marconi, P., Marino, R., Marki, J., Mark, G., Martellotti, A., Marten, A. M., Sanchez, M., Martinelli, D. M., Santo, D. M., Toste, A., Massafferri, R., Matev, Z., Mathe, C., Matteuzzi, E., Maurice, A., Mazurov, B. M., Skelly, J., Mccarthy, A., Mcnab, R., Mcnulty, B., Meadow, F., Meier, M., Meissner, M., Merk, D. A., Milane, M. N., Minard, J. M., Rodriguez, S., Montei, D., Moran, P., Morawski, A., Morda, Morello, MICHAEL JOSEPH, R., Mountain, I., Mou, F., Muheim, K., Muller, R., Muresan, B., Muryn, B., Muster, P., Naik, T., Nakada, R., Nandakumar, I., Nasteval, M., Needham, S., Neubert, N., Neufeld, A. D., Nguyen, T. D., Nguyen, C., Nguyen Mau, M., Nicol, V., Nie, R., Niet, N., Nikitin, T., Nikodem, A., Nomerotski, A., Novoselov, A., Oblakowska Mucha, V., Obraztsov, S., Oggero, S., Ogilvy, O., Okhrimenko, R., Odeman, M., Orlandea, J. M., O., P., Owen, A., Oyanguren, B. K., Pal, A., Palano, M., Palutan, J., Panman, A., Papanesti, M., Pappagallo, C., Parke, C. J., Parkinson, G., Passaleva, G. D., Patel, M., Patel, G. N., Patrick, C., Patrignani, C., Pavel Nicorescu, A. P., Alvarez, A., Pellegrino, G., Penso, M. P., Altarelli, S., Perazzini, E. P., Trigo, A. P., C., P., Perret, M., Perrin Terrin, L., Pescatore, G., Pessina, K., Petridi, A., Petrolini, A., Phan, E. P., Olloqui, B., Pietrzyk, T., Pilar, D., Pinci, S., Playfer, M. P., Casasu, F., Polci, G., Polok, A., Poluektov, E., Polycarpo, A., Popov, D., Popov, B., Popovici, C., Potterat, A., Powell, J., Prisciandaro, A., Pritchard, C., Prouve, V., Pugatch, A. P., Navarro, G., Punzi, W., Qian, J. H., Rademacker, B., Rakotomiaramanana, M. S., Rangel, I., Raniuk, N., Rauschmayr, G., Raven, S., Redford, M. M., Reid, A. C., Do, S., Ricciardi, A., Richard, K., Rinnert, V. R., Molina, D. A., R., P., Robbe, D. A., Robert, E., Rodrigue, P. R., Perez, S., Roiser, V., Romanovsky, A. R., Vidal, J., Rouvinet, T., Ruf, F., Ruffini, H., Ruiz, P. R., Vall, G., Sabatino, J. J., S., N., Sagidova, P., Sail, B., Saitta, V. S., Guimarae, C., Salzmann, B. S., Sede, M., Sannino, R., Santacesaria, C. S., Rio, E., Santovetti, M., Sapunov, A., Sarti, C., Satriano, A., Satta, M., Savrie, D., Savrina, P., Schaack, M., Schiller, H., Schindler, M., Schlupp, M., Schmelling, B., Schmidt, O., Schneider, A., Schopper, M. H., Schune, R., Schwemmer, B., Sciascia, A., Sciubba, M., Seco, A., Semennikov, I., Sepp, N., Serra, J., Serrano, P., Seyfert, M., Shapkin, I., Shapoval, P., Shatalov, Y., Shcheglov, T., Shear, L., Shekhtman, O., Shevchenko, V., Shevchenko, A., Shire, R. S., Coutinho, M., Sirendi, T., Skwarnicki, N. A., Smith, E., Smith, J., Smith, M., Smith, M. D., Sokoloff, F. J., P., F., Soomro, D., Souza, B. S., De, B., Spam, A., Sparke, P., Spradlin, F., Stagni, S., Stahl, O., Steinkamp, S., Stoica, S., Stone, B., Storaci, M., Straticiuc, U., Straumann, V. K., Subbiah, L., Sun, S., Swientek, V., Syropoulo, M., Szczekowski, P., Szczypka, T., Szumlak, S., T'Jampen, M., Teklishyn, E., Teodorescu, F., Teubert, C., Thoma, E., Thoma, J. v., Tilburg, V., Tisserand, M., Tobin, S., Tok, D., Tonelli, S., Topp Joergensen, N., Torr, E., Tournefier, S., Tourneur, M. T., Tran, M., Tresch, A., Tsaregorodtsev, P., Tsopela, N., Tuning, M. U., Garcia, A., Ukleja, D., Urner, A., Ustyuzhanin, U., Uwer, V., Vagnoni, G., Valenti, A., Vallier, M. V., Dijk, R. V., Gomez, P. V., Regueiro, C. V., Sierra, S., Vecchi, J. J., Velthui, M., Veltri, G., Veneziano, M., Vesterinen, B., Viaud, D., Vieira, X., Vilasis Cardona, A., Vollhardt, D., Volyanskyy, D., Voong, A., Vorobyev, V., Vorobyev, C., Vo, H., Vo, R., Waldi, C., Wallace, R., Wallace, S., Wandernoth, J., Wang, D. R., Ward, N. K., Watson, A. D., Webber, D., Websdale, M., Whitehead, J., Wicht, J., Wiechczynski, D., Wiedner, L., Wigger, G., Wilkinson, M. P., William, M., William, F. F., Wilson, J., Wimberley, J., Wishahi, M., Witek, S. A., Wotton, S., Wright, S., Wu, K., Wyllie, Y., Xie, Z., Xing, Z., Yang, R., Young, X., Yuan, O., Yushchenko, M., Zangoli, M., Zavertyaev, F., Zhang, L., Zhang, W. C., Zhang, Y., Zhang, A., Zhelezov, A., Zhokhov, L., Zhong, A., Zvyagin, Aaij, R, Adeva, B, Adinolfi, M, Adrover, C, Affolder, A, Ajaltouni, Z, Albrecht, J, Alessio, F, Alexander, M, Ali, S, Alkhazov, G, Alvarez Cartelle, P, Alves, A, Amato, S, Amerio, S, Amhis, Y, Anderlini, L, Anderson, J, Andreassen, R, Andrews, J, Appleby, R, Gutierrez, O, Archilli, F, Artamonov, A, Artuso, M, Aslanides, E, Auriemmam, G, Baalouch, M, Bachmann, S, Back, J, Baesso, C, Balagura, V, Baldini, W, Barlow, R, Barsche, C, Barsuk, S, Barter, W, Bauer, T, Bay, A, Beddow, J, Bedeschi, F, Bediagal, I, Belogurov, S, Belous, K, Belyaev, I, Ben Haim, E, Bencivenni, G, Benson, S, Benton, J, Berezhnoy, A, Bernet, R, Bettler, M, van Beuzekom, M, Bien, A, Bifani, S, Bird, T, Bizzeti, A, Bjornstad, P, Blake, T, Blanc, F, Blouw, J, Blusk, S, Bocci, V, Bondar, A, Bondar, N, Bonivento, W, Borghi, S, Borgia, A, Bowcock, T, Bowen, E, Bozzi, C, Brambach, T, van den Brand, J, Bressieux, J, Brett, D, Britschl, M, Britton, T, Brook, N, Brown, H, Burducea, I, Bursche, A, Busettoq, G, Buytaert, J, Cadeddu, S, Callot, O, Calvi, M, Calvo Gomez, M, Camboni, A, Campana, P, Perez, D, Carbone, A, Carboni, G, Cardinale, R, Cardini, A, Carranza Mejia, H, Carson, L, Carvalho Akiba, K, Casse, G, Garcia, L, Cattaneo, M, Cauet, C, Cenci, R, Charles, M, Charpentier, P, Chen, P, Chiapolini, N, Chrzaszcz, M, Ciba, K, Vida, X, Ciezarek, G, Clarke, P, Clemencic, M, Cliff, H, Closier, J, Coca, C, Coco, V, Cogan, J, Cogneras, E, Collins, P, Comerma Montells, A, Contu, A, Cook, A, Coombes, M, Coquereau, S, Corti, G, Couturier, B, Cowan, G, Craik, D, Cunliffe, S, Currie, R, D'Ambrosio, C, David, P, Davis, A, De Bonis, I, De Bruyn, K, De Capua, S, De Cian, M, De Mirandal, J, De Paula, L, De Silva, W, De Simone, P, Decamp, D, Deckenhoff, M, Del Buono, L, Deleage, N, Derkach, D, Deschamps, O, Dettori, F, Di Canton, A, Di Ruscio, F, Dijkstra, H, Dogaru, M, Donleavy, S, Dordeill, F, Dosil Suarez, A, Dossett, D, Dovbnya, A, Dupertuis, F, Durante, P, Dzhelyadin, R, Dziurda, A, Dzyuba, A, Easo, S, Egede, U, Egorychev, V, Eidelman, S, van Eijk, D, Eisenhardt, S, Eitschberger, U, Ekelhof, R, Eklund, L, El Rifai, I, Elsasser, C, Falabellae, A, Farber, C, Fardell, G, Farinelli, C, Farry, S, Fave, V, Ferguson, D, Fernandez Albor, V, Ferreira Rodrigues, F, Ferro Luzzi, M, Filippov, S, Fiore, M, Fitzpatrick, C, Fontana, M, Fontanelli, F, Forty, R, Francisco, O, Frank, M, Frei, C, Frosini, M, Furcas, S, Furfaro, E, Gallas Torreira, A, Galli, D, Gandelman, M, Gandini, P, Gao, Y, Garofoli, J, Garosi, P, Tico, J, Garrido, L, Gaspar, C, Gauld, R, Gersabeck, E, Gersabeck, M, Gershon, T, Ghez, P, Gibson, V, Giubega, L, Gligorov, V, Goebel, C, Golubkov, D, Golutvin, A, Gomes, A, Gordon, H, Gandara, M, Graciani Diaz, R, Cardoso, L, Grauges, E, Graziani, G, Grecu, A, Greening, E, Gregson, S, Griffith, P, Gruenberg, O, Gui, B, Gushchin, E, Guz, Y, Gys, T, Hadjivasiliou, C, Haefeli, G, Haen, C, Haines, S, Hal, S, Hamilton, B, Hampson, T, Hansmann Menzemer, S, Harnew, N, Harnew, S, Harrison, J, Hartmann, T, He, J, Head, T, Heijne, V, Hennessy, K, Henrard, P, Hernando Morata, J, van Herwijnen, E, Hicheurl, A, Hicks, E, Hill, D, Hoballah, M, Holtrop, M, Hombach, C, Hopchev, P, Hulsbergen, W, Hunt, P, Huse, T, Hussain, N, Hutchcroft, D, Hynds, D, Iakovenko, V, Idzik, M, Ilten, P, Jacobsson, R, Jaeger, A, Jans, E, Jaton, P, Jawahery, A, Jing, F, John, M, Johnson, D, Jones, C, Joram, C, Jost, B, Kaballo, M, Kandybei, S, Kanso, W, Karacson, M, Karbach, T, Kenyon, I, Kete, T, Keune, A, Khanji, B, Kochebina, O, Komarov, I, Koopman, R, Koppenbure, P, Korolev, M, Kozlinskiy, A, Kravchuk, L, Krepin, K, Kreps, M, Krocker, G, Krokovny, P, Kruse, F, Kucharczyk, M, Kudryavtsev, V, Kvaratskheliya, T, La Thi, V, Lacarrere, D, Lafferty, G, Lai, A, Lambert, D, Lambert, R, Lanciotti, E, Lanfranchi, G, Langenbruch, C, Latham, T, Lazzeroni, C, Le Gac, R, van Leerdam, J, Lees, J, Leievre, R, Leflat, A, Lefrancois, J, Leo, S, Leroy, O, Lesiak, T, Leverington, B, Li, Y, Li Gioi, L, Liles, M, Lindner, R, Linn, C, Liu, B, Liu, G, Lohn, S, Longstaff, I, Lopes, J, Lopez March, N, Lu, H, Lucchesi, D, Luisier, J, Luo, H, Machefert, F, Machikhiliyan, I, Maciuc, F, Maev, O, Malde, S, Manca, G, Mancinelli, G, Maratas, J, Marconi, U, Marino, P, Marki, R, Marks, J, Martellotti, G, Martens, A, Sanchez, A, Martinelli, M, Santos, D, Martins Tostes, D, Massafferri, A, Matev, R, Mathe, Z, Matteuzzi, C, Maurice, E, Mazurov, A, Mc Skelly, B, Mccarthy, J, Mcnab, A, Mcnulty, R, Meadows, B, Meier, F, Meissner, M, Merk, M, Milanes, D, Minard, M, Rodriguez, J, Montei, S, Moran, D, Morawski, P, Morda, A, Morello, M, Mountain, R, Mous, I, Muheim, F, Mueller, K, Muresan, R, Muryn, B, Muster, B, Naik, P, Nakada, T, Nandakumar, R, Nasteval, I, Needham, M, Neubert, S, Neufeld, N, Nguyen, A, Nguyen, T, Nguyen Mau, C, Nicol, M, Niess, V, Niet, R, Nikitin, N, Nikodem, T, Nomerotski, A, Novoselov, A, Oblakowska Mucha, A, Obraztsov, V, Oggero, S, Ogilvy, S, Okhrimenko, O, Odeman, R, Orlandea, M, Otalora Goicochea, J, Owen, P, Oyanguren, A, Pal, B, Palano, A, Palutan, M, Panman, J, Papanestis, A, Pappagallo, M, Parkes, C, Parkinson, C, Passaleva, G, Patel, G, Patel, M, Patrick, G, Patrignani, C, Pavel Nicorescu, C, Pazos Alvarez, A, Pellegrino, A, Penso, G, Altarelli, M, Perazzini, S, Perez Trigo, E, Perez Calero Yzquierdo, A, Perret, P, Perrin Terrin, M, Pescatore, L, Pessina, G, Petridis, K, Petrolini, A, Phan, A, Picatoste Olloqui, E, Pietrzyk, B, Pilar, T, Pinci, D, Playfer, S, Plo Casasus, M, Polci, F, Polok, G, Poluektov, A, Polycarpo, E, Popov, A, Popov, D, Popovici, B, Potterat, C, Powell, A, Prisciandaro, J, Pritchard, A, Prouve, C, Pugatch, V, Navarro, A, Punzi, G, Qian, W, Rademacker, J, Rakotomiaramanana, B, Rangel, M, Raniuk, I, Rauschmayr, N, Raven, G, Redford, S, Reid, M, dos Reis, A, Ricciardi, S, Richards, A, Rinnert, K, Rives Molina, V, Romero, D, Robbe, P, Roberts, D, Rodrigues, E, Rodriguez Perez, P, Roiser, S, Romanovsky, V, Romero Vidal, A, Rouvinet, J, Ruf, T, Ruffini, F, Ruiz, H, Ruiz Valls, P, Sabatino, G, Saborido Silva, J, Sagidova, N, Sail, P, Saitta, B, Salustino Guimaraes, V, Salzmann, C, Sanmartin Sedes, B, Sannino, M, Santacesaria, R, Santamarina Rios, C, Santovetti, E, Sapunov, M, Sarti, A, Satriano, C, Satta, A, Savrie, M, Savrina, D, Schaack, P, Schiller, M, Schindler, H, Schlupp, M, Schmelling, M, Schmidt, B, Schneider, O, Schopper, A, Schune, M, Schwemmer, R, Sciascia, B, Sciubba, A, Seco, M, Semennikov, A, Sepp, I, Serra, N, Serrano, J, Seyfert, P, Shapkin, M, Shapoval, I, Shatalov, P, Shcheglov, Y, Shears, T, Shekhtman, L, Shevchenko, O, Shevchenko, V, Shires, A, Coutinho, R, Sirendi, M, Skwarnicki, T, Smith, N, Smith, E, Smith, J, Smith, M, Sokoloff, M, Soler, F, Soomro, F, Souza, D, Souza De Paula, B, Spam, B, Sparkes, A, Spradlin, P, Stagni, F, Stahl, S, Steinkamp, O, Stoica, S, Stone, S, Storaci, B, Straticiuc, M, Straumann, U, Subbiah, V, Sun, L, Swientek, S, 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Zangoli, M, Zavertyaev, M, Zhang, F, Zhang, L, Zhang, W, Zhang, Y, Zhelezov, A, Zhokhov, A, Zhong, L, and Zvyagin, A
- Subjects
Heavy Flavour Physics, LHC Collider ,Flavor physics ,Hadron-Hadron Scattering ,Branching fraction ,B physics ,Settore FIS/04 - Fisica Nucleare e Subnucleare - Abstract
The results of searches for B-(s)(0) -> J/psi p (p) over bar and B+ J/psi p (p) over bar pi(+) decays are reported. The analysis is based on a data sample, corresponding to an integrated luminosity of 1.0 fb(-1) of pp collisions, collected with the LHCb detector. An excess with 2.8 sigma significance is seen for the decay B-(s)(0) -> J/psi p (p) over bar and an upper limit on the branching fraction is set at the 90% confidence level: B(B-(s)(0) -> J/psi p (p) over bar) < 4.8 x 10(-6), which is the first such limit. No significant signals are seen for B-0 -> J/psi p and B+ -> J/psi p (p) over bar pi(+) decays, for which the corresponding limits are set: B(B-0 -> J/psi p (p) over bar) < 5.2 x 10(-7), which significantly improves the existing limit; and B(B+ -> J/psi ppi(+)) < 5.0 x 10(-7), which is the first limit on this branching fraction.
- Published
- 2013
12. writing, writing dispositions and attitude to English
- Author
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Tok, S and Kandemir, A
- Subjects
achievement ,creative writing ,writing disposition ,English course attitude ,writing - Abstract
This experimental study investigates the effects of using creative writing activities on 7th grade students' achievement in writing skill, writing dispositions and their attitude to English. One group pre and post test design was used in the study. The study was conducted during four weeks in 2012-2013 academic year in an elementary school in the city centre of Denizli, Turkey. The study group was consisted of 17 female and 14 males in total 31 seventh grade students. When pre and post test results were compared it was found that students' achievement in writing skill was increased after the experiment. Students' writing disposition was also increased when compared to their levels before the experiment. However, students' attitude to English course was not increased after the experiment. Results indicate that using creative writing exercises has a positive effect on writing achievement and writing disposition in 7th grade English language classes in elementary schools. (C) 2015 The Authors. Published by Elsevier Ltd.
- Published
- 2015
13. The effect of Stories for Thinking on reading and listening
- Author
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Tok, S and Mazi, A
- Subjects
listening comprehension ,education ,philosophy for children ,stories for thinking ,reading comprehension - Abstract
This study has been conducted in order to examine the effects of the stories for thinking on 5th graders' reading comprehension and listening comprehension. A pretest-post test control group quasi-experimental design was used in the study. The sample of the etstudy was composed of 74 5th graders attending public elementary schools. The data have been collected by administering the 'reading comprehension test' and the 'Listening Comprehension Test'. While 'stories for thinking' was applied to the study group, various activities were applied to the control group. The results of the study showed that there was no evidence that the stories for thinking experience added statistically significant value to the students' reading and listening comprehension in relation to the control group.
- Published
- 2015
14. Computed tomography angiography spot sign as a predictor for outcome for patients with intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage
- Author
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Burkhardt, JK, Neidert, M, Stienen, MN, Schöni, D, Fung, C, Röthlisberger, M, Corniola, M, Bervini, D, Maduri, R, Valsecchi, D, Tok, S, Schatlo, B, Schaller, K, Regli, L, group, OBobotSSs, Burkhardt, JK, Neidert, M, Stienen, MN, Schöni, D, Fung, C, Röthlisberger, M, Corniola, M, Bervini, D, Maduri, R, Valsecchi, D, Tok, S, Schatlo, B, Schaller, K, Regli, L, and group, OBobotSSs
- Published
- 2015
15. Model-independent search for CP violation in D-0 > K-K+pi(-)pi(+) and D-0 -> pi(-)pi(+)pi(+)pi(-) decays
- Author
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Aaij, R., Adeva, B., Adinolfi, M., Adrover, C., Affolder, A., Ajaltouni, Z., Albrecht, J., Alessio, F., Alexander, M., Ali, S., Alkhazov, G., Cartelle, P. A., Alves, A. A., Amato, S., Amerio, Silvia, Amhis, Y., Anderlini, L., Anderson, J., Andreassen, R., Andrews, J. E., Appleby, R. B., Gutierrez, O. A., Archilli, F., Artamonov, A., Artuso, M., Aslanides, E., Auriemma, G., Baalouch, M., Bachmann, S., Back, J. J., Baesso, C., Balagura, V., Baldini, W., Barlow, R. J., Barsche, C., Barsuk, S., Barter, W., Bauer, T., Bay, A., Beddow, J., Bedeschi, E., Bediaga, I., Belogurov, S., Belous, K., Belyaev, I., Ben Haim, E., Bencivenni, G., Benson, S., Benton, J., Berezhnoy, A., Bernet, R., Bettler, M. O., Beuzekom, M. V., Bien, A., Bifani, S., Bird, T., Bizzeti, A., Bjornstad, P. M., Blake, T., Blanc, F., Blouw, J., Blusk, S., Bocci, V., Bondar, A., Bondar, N., Bonivento, W., Borghi, S., Borgia, A., T. J. V., Bowen, E., Bozzi, C., Brambach, T., Den, J. V., Bressieux, J., Brett, D., Britsch, M., Britton, T., Brook, N. H., Brown, H., Burducea, I., Bursche, A., Busetto, Giovanni, Buytaert, J., Cadeddu, S., Callot, O., Calvi, M., Gomez, M. C., Camboni, A., Campana, P., Perez, D. C., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carranza Mejia, H., Carson, L., Akiba, K. C., Casse, G., Garcia, L. C., Cattaneo, M., Cauet, C., Cenci, R., Charles, M., Charpentier, P., Chen, P., Chiapolini, N., Chrzaszcz, M., Ciba, K., Vida, X. C., Ciezarek, G., P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Coca, C., Coco, V., Cogan, J., Cogneras, E., Collins, P., Comerma Montells, A., Contu, A., Cook, A., Coombes, M., Coquereau, S., Corti, G., Couturier, B., Cowan, G. A., Cowie, E., Craik, D. C., Cunliffe, S., Currie, R., D'Ambrosio, C., David, P., P. N. Y., Davis, A., Bonis, I. D., Bruyn, K. D., Capua, S. D., Cian, M. D., J. M., De, Paula, L. D., Silva, W. D., Simone, R. D., Decamp, D., Deckenhoff, M., Buono, L. 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F., Wilson, J., Wimberley, J., Wishahi, W., Wislicki, M., Witek, S. A., Wotton, S., Wright, S., Wu, K., Wyllie, Y., Xie, Z., Xing, Z., Yang, R., Young, X., Yuan, O., Yushchenko, M., Zangoli, M., Zavertyaev, F., Zhang, L., Zhang, W. C., Zhang, Y., Zhang, A., Zhelezov, A., Zhokhov, L., Zhong, and A., Zvyagin
- Abstract
A search for CP violation in the phase-space structures of 130 and 15 decays to the final states K-K+pi(-)pi(+) and pi(-)pi(+)pi(+)pi(-) is presented. The search is carried out with a data set corresponding to an integrated luminosity of 1.0 fb(-1) collected in 2011 by the LHCb experiment in pp collisions at a centre-of-mass energy of 7 TeV. For the K-K+pi(-)pi(+) final state, the four-body phase space is divided into 32 bins, each bin with approximately 1800 decays. The p-value under the hypothesis of no CP violation is 9.1%, and in no bin is a CP asymmetry greater than 6.5% observed. The phase space of the pi(-)pi(+)pi(+)pi(-). final state is partitioned into 128 bins, each bin with approximately 2500 decays. The p-value under the hypothesis of no CP violation is 41%, and in no bin is a CP asymmetry greater than 5.5% observed. All results are consistent with the hypothesis of no CP violation at the current sensitivity. (C) 2013 CERN. Published by Elsevier B.V. All rights reserved.
- Published
- 2013
16. The examination of middle ear ossicles with preoperative 64-detector computed tomography in cases with chronic otitis media and cholesteatoma and comparison of operation findings
- Author
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Tok S., Adapinar B., Incesulu A., and Gurbuz M.K.
- Abstract
Introduction: Chronic Otitis Media (COM) is among the common infectious diseases seen in developing countries. This disease can either affect the tympanic membrane focally or can cause several complications by penetrating through to the temporal bone. Cholesteatoma is an inflammatory disease of the temporal bone. Objective: The objective of this study is to evaluate the middle ear ossicle preoperatively with 64 detector tomography in patients with COM and cholesteatoma and to determine the correlations with the operative results. Materials and Results: This prospective study included 100 cases. Surgery is considered the golden standard for treatment. With multi-slice computed tomography (CT), upon evaluation of the middle ear ossicles of the 100 cases; the sensitivity and specificity for the malleus was found to be 95,1% and and 92,3% respectively, sensitivity and specificity for the incus was 84,6% and 98,4% respectively and the specificity and sensitivity for the stapes was found to be 71,2% and 100% respectively. With multi-slice CT, the highest sensitivity was found for the malleus anterior process (97,1%) and the lowest sensitivity was found for the stapes anterior crus (71,2%). Conclusion: Consequently, 64 detector computerized tomography can be used with high accuracy in the preoperative evaluation of the middle ear ossicles. Copyright 2005 © The Mediterranean Society of Otology and Audiology.
- Published
- 2013
17. achievement, anxiety and metacognitive skills
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Tok, S
- Subjects
Metacognition ,Mathematics achievement ,Math anxiety ,KWL strategy - Abstract
This study was conducted in order to examine the effects of the Know-Want-Learn (KWL) strategy on 6th graders' mathematics achievement, metacognitive skills and mathematics anxiety. A pretest-post test control group quasi- experimental design was used in the study. The sample of the study was composed of 55 6th graders attending public elementary schools. The data have been collected by administering the "Math Achievement Test", "Metacognition Inventory" and the "Math Anxiety Scale". The "KWL strategy" was used in teaching mathematics to the study group whereas the control group was taught using the "traditional method". The results of the study showed that employing the "KWL strategy" in 6th grade mathematics can be effective in increasing achievement and metacognition while it was no efficient than the traditional method regarding the reduction of anxiety.
- Published
- 2013
18. Psychophysiological responses to competition and the big five personality traits
- Author
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Binboga E., Guven S., Çatikkaş F., Bayazit O., Tok S., and Ege Üniversitesi
- Subjects
electrodermal activity ,Personality ,sport psychology - Abstract
This study examines the relationship between psychophysiological arousal, cognitive anxiety, and personality traits in young taekwondo athletes. A total of 20 male and 10 female taekwondo athletes (mean age = 18.6 years; ± 1.8) volunteered for the study. The Five Factor Personality Inventory and the state scale of the Spielberger State-Trait Anxiety Inventory (STAI) were used to measure personality and cognitive state anxiety. Electrodermal activity (EDA) was measured twice, one day and approximately one hour prior to the competition, to determine psychophysiological arousal. Descriptive statistics, Pearson product-moment correlations, and stepwise regression were used to analyze the data. Several "Big Five" facets were related to the EDA delta scores that were measured both one day and one hour before the competition. Two stepwise regressions were conducted to examine whether personality traits could significantly predict both EDA delta scores. The final model, containing only neuroticism from the Big Five factors, can significantly explain the variations in the EDA delta scores measured one day before the competition. Agreeableness can significantly explain variations in the EDA delta scores measured one hour before the competition. No relationship was found between cognitive anxiety and the EDA delta scores measured one hour before the competition. In conclusion, personality traits, especially agreeableness and neuroticism, might be useful in understanding arousal responses to competition. © Editorial Committee of Journal of Human Kinetics.
- Published
- 2012
19. Pre-service primary education teachers' changing attitudes towards
- Author
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Tok, S
- Subjects
mental disorders ,education ,sense organs ,teacher education ,elementary pre-service teachers ,attitudes towards ,behavioral disciplines and activities ,teaching - Abstract
This study investigated the longitudinal changes in the attitudes of pre-service primary education teachers towards the teaching profession as they progressed through training. The results indicate that there is a significant difference in pre-service teachers' attitudes towards the profession between their freshman and senior years. Moreover, the findings obtained through interview data have shown that both positive and negative changes occur in pre-service teachers' attitudes towards teaching throughout their education, and these changes are observed to be related to teaching practice, cooperating teachers, teacher education institutions and teacher educators.
- Published
- 2011
20. Adaptation of the revised schutte emotional intelligence scale into turkish and examination of its psychometric properties [Gözden geçirilmiş schutte duygusal zekâ ölçeginin türkçe'ye uyarlanmasi{dotless} ve psikometrik özelliklerinin i·ncelenmesi]
- Author
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Tatar A., Tok S., Saltukoglu G., and Ege Üniversitesi
- Subjects
Scale adaptation ,Emotional intelligence ,Schutte emotional intelligence scale - Abstract
Objective: Although emotional intelligence is not a new term, as a conceptual framework it is relatively new and the tools to measure it are rather few, a situation that is also reflected in Turkish literature. Therefore, in this study we aimed to adapt the Schutte Emotional Intelligence Scale, developed by Schutte, Malouff, Hall, Haggerty, Cooper, Golden, Dornheim, (1998) (33 item) and revised by Austin, Saklofske, Huang, McKenney, (2004) (41 item), into Turkish. Method: After the translation of the scale into Turkish, 1022 females (58.6%) and 721 males (41.4%), a total of 1743 subjects, ranging in age from 17 to 78 years, completed the Schutte Emotional Intelligence Scale. Results: The examination of the three-factor structure of the scale by explanatory and confirmatory factor analyses showed that the results were consistent with those reported by Austin et al. (2004). The Cronbach-Alfa internal consistency coefficient for the entire scale was 0.82 and for the subscales was 0.75, 0.39 and 0.76. Test- retest reliability for the entire scale within one week was found to be r=0.49 (n=88), and within two weeks it was r=0.56 (n=85). To examine the scale's discriminant validity, the Five Factor Personality Inventory was administered to 100 subjects in addition to the Emotional Intelligence Scale. The results indicated that there were significant correlations between the Schutte Emotional Intelligence Scale and the personality traits ranging from -0.29 to 0.34. Emotional intelligence scores for the entire scale were compared in terms of gender, age, and educational levels. The results showed that females had significantly higher emotional intelligence scores than males and as the level of education increased so too did the scores of emotional intelligence. Conclusion: The results indicate that the Schutte Emotional Intelligence scale can be a reliable and valid instrument to be used for the Turkish population. However, further studies are needed to examine the factor structure of the scale.
- Published
- 2011
21. Clinical and Radiological Characteristics of Aneurysmal Subarachnoid Hemorrhage in Older Adults
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Röthlisberger, M., primary, Zumofen, D., additional, Schatlo, B., additional, Stienen, M., additional, Sailer, M., additional, Fung, C., additional, Burkhardt, J., additional, Tok, S., additional, D'Alonzo, D., additional, Marbacher, S., additional, Hiroki, D., additional, Dell-Kuster, S., additional, Achermann, R., additional, Corniola, M., additional, Bervini, D., additional, Fathi, A., additional, Daniel, R., additional, Hildebrandt, G., additional, Regli, L., additional, Reinert, M., additional, Raabe, A., additional, Fandino, J., additional, Bijlenga, P., additional, Schaller, K., additional, Keller, E., additional, Mariani, L., additional, and Guzman, R., additional
- Published
- 2015
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- View/download PDF
22. Incidence, Therapy, and Outcome of Aneurysmal Subarachnoid Hemorrhage. The Swiss Study on Aneurysmal Subarachnoid Hemorrhage (Swiss SOS)
- Author
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Schatlo, B., primary, Fung, C., additional, Stienen, M., additional, Fathi, A., additional, Fandino, J., additional, Smoll, N., additional, Tok, S., additional, Daniel, R., additional, Zumofen, D., additional, Burkhard, J., additional, Dan-Ura, H., additional, Röthlisberger, M., additional, Reinert, M., additional, Winkler, K., additional, Ahlborn, P., additional, Mendes-Pereira, V., additional, D́Alonzo, D., additional, Seule, M., additional, Kerkeni, H., additional, Bervini, D., additional, Sailer, M., additional, Kuhlen, D., additional, Remonda, L., additional, Rohde, V., additional, Mostaguir, K., additional, Marbacher, S., additional, Valsecchi, D., additional, Corniola, M., additional, Schöni, D., additional, Woernle, C., additional, Regli, L., additional, Levivier, M., additional, Hildebrandt, G., additional, Mariani, L., additional, Beck, J., additional, Guzman, R., additional, Raabe, A., additional, Bijlenga, P., additional, Keller, E., additional, and Schaller, K., additional
- Published
- 2015
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- View/download PDF
23. Computed Tomography Angiography Spot Sign as a Predictor for Outcome for Patients with Intracerebral Hemorrhage and Aneurysmal Subarachnoid Hemorrhage
- Author
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Burkhardt, J., primary, Neidert, M., additional, Stienen, M., additional, Schöni, D., additional, Fung, C., additional, Röthlisberger, M., additional, Corniola, M., additional, Bervini, D., additional, Maduri, R., additional, Valsecchi, D., additional, Tok, S., additional, Schatlo, B., additional, Schaller, K., additional, Bozinov, O., additional, and Regli, L., additional
- Published
- 2015
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24. Attitudes Toward Teaching Profession, Performance and Reflections
- Author
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Tok, S
- Subjects
Reflective thinking ,teacher education ,two column writings - Abstract
The aim of this study is to determine the impact of reflective thinking activities on the student teachers' attitudes toward teaching proffession, performance and their reflections. Sample Of the Study is the 63, 1st grade students who are studying at MKU Faculty of Education, Department of Elementary Education. The data has been collected through two coloumn writings during 12 weeks study icluding reflective thinking development activities. Findings reveal that there is a significant difference between experimental and control group in favor of experimental group with respect to the attitudes toward teaching profession. Furthermore, the reflective thinking activities have a positive influence on the performances of the students in experimental group. In addition to this, the Students' reflections about their own Studies, learning activities, and the instructor's attitudes are discussed in this study taking the students'
- Published
- 2008
25. achievement
- Author
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Tok, S
- Subjects
learning strategy ,know-want-learn strategy ,note taking strategy - Abstract
The purpose of this study is to compare the KWL and note-taking strategies with the traditional method in Science and Technology Course of the fifth grade students at elemantary school, and to determine the academic achievement and attitudes toward science course. This quasi -experimental study with "pre-post test and control group" design was carried out during the spring semester of 2005-2006 academic year. The sample of the study was composed of 121 fifth graders attending public elementary schools located in city center of Hatay. The data has been collected by administering "Science Achievement Test" and "Science Attitude Scale". Science and Technology course was instructed to the first group by "KWL strategy", by "notetaking strategy" to the second group, and the by "traditional method" to the control group. The results of the study showed that "notetaking and KWL strategies" in the 5(th) grade Sience and Technology courses can be effective for increasing the academic achievement.
- Published
- 2008
26. The effect of Diphtheria Toxin and antioxidants on neuromuscular junction of Guinea Pig
- Author
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Tok, S., primary, Zengin, A., additional, Nurten, A., additional, and Nurten, R., additional
- Published
- 2010
- Full Text
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27. Protective effect of saponins from Argania spinosa against free radical-induced oxidative haemolysis
- Author
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Amzal, H., primary, Alaoui, K., additional, Tok, S., additional, Errachidi, A., additional, Charof, R., additional, Cherrah, Y., additional, and Benjouad, A., additional
- Published
- 2008
- Full Text
- View/download PDF
28. Intercostolumbar Spinal Nerve Anastomosis
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TOK, S., primary, SCHMID, U. D., additional, FERBERT, A., additional, and DAVENPORT, T., additional
- Published
- 1991
- Full Text
- View/download PDF
29. Exh�rese bei Okzipitalneuralgie.
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Oh, S., Tok, S., Allemann, J., Prevost, A., and Schmid, U. D.
- Published
- 1983
- Full Text
- View/download PDF
30. Exhärese bei Okzipitalneuralgie
- Author
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Prevost A, Oh S, Allemann J, Schmid Ud, and Tok S
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Rhizotomy ,Retrospective cohort study ,General Medicine ,medicine.disease ,Neuroma ,nervous system diseases ,Surgery ,body regions ,medicine.anatomical_structure ,Occipital neuralgia ,Trigeminal neuralgia ,Scalp ,Neuralgia ,medicine ,Neurology (clinical) ,business ,Cervical vertebrae - Abstract
31 patients, suffering from an occipital neuralgia, were treated surgically by section of the n. occipitalis major or minor. The retrospective study of these cases extends over a period of one to nine years. In 26 patients (84%) a good result was achieved initially, and 16 patients (52%) are completely free of any complaint up to the present. In five patients (16%) no improvement has occurred. In two of these five patients an epipharyngeal cancer was discovered later; in one of the patients trigeminal neuralgia was established later on. Contrary to earlier published intradural rhizotomy this operation is simple and without risk (it is performed under local anaesthesia), and in long-standing, obstinate and tormenting cases very good results can thus be achieved. The unclear aetiology of the neuralgia was observed anatomically by the atypical course of the nerves. Other methods for the treatment of occipital neuralgia were not considered here.
- Published
- 1983
31. China-ASEAN Relations, April 2005 to September 2005: Chronology of Events
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Tok, Sow Keat
- Published
- 2006
- Full Text
- View/download PDF
32. China-ASEAN Relations, October 2004 to March 2005: Chronology of Events
- Author
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Tok, Sow Keat
- Published
- 2005
- Full Text
- View/download PDF
33. Neither Friends Nor Foes: China's Dilemmas in Managing Its Japan Policy
- Author
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Tok, Sow Keat
- Published
- 2005
- Full Text
- View/download PDF
34. China-ASEAN Relations, April to September 2004: Chronology of Events
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Yow, Cheun Hoe and Tok, Sow Keat
- Published
- 2005
- Full Text
- View/download PDF
35. Exhärese bei Okzipitalneuralgie
- Author
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Oh, S., primary, Tok, S., additional, Allemann, J., additional, Prevost, A., additional, and Schmid, U., additional
- Published
- 1983
- Full Text
- View/download PDF
36. China-ASEAN Relations, October 2004 to March 2005: Important Documents
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Tok, Sow Keat
- Published
- 2005
- Full Text
- View/download PDF
37. Resources for China-ASEAN Relations, April to September 2004: Important Documents
- Author
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Tok, Sow Keat
- Published
- 2005
- Full Text
- View/download PDF
38. Comparison of Heart Rate Variability Psychological Responses and Performance in Virtual and Real Archery.
- Author
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Dal N, Tok S, Balıkçı İ, Yılmaz SE, and Binboğa E
- Subjects
- Humans, Female, Male, Young Adult, Adult, Anxiety physiopathology, Psychomotor Performance physiology, Heart Rate physiology, Virtual Reality, Respiratory Rate physiology
- Abstract
Background: This study examines the psychophysiological differences between virtual reality (VR) and real archery. It explores whether VR archery induces heart rate (HR), heart rate variability (HRV), and breathing rates similar to those experienced in real archery. Additionally, the study assesses differences in perceived anxiety, difficulty, confidence, rate of perceived exertion (RPE), and shooting performance between the two modalities, providing insights into the efficacy of VR as a training tool for archery., Methods: Twenty-two (women: 8) individuals aged 20-24 participated in the study. We first recorded individuals' resting HR, HRV, and breathing rates during baseline. Afterward, participants shot 10 real and virtual arrows from 18 m, whereas their HR, HRV, and breathing rate were measured, each lasting 4 min. Performance in VR and real archery was determined separately as the sum of the shots. We performed paired sample t-tests to compare individuals' performance, psychological, and psychophysiological responses recorded during VR and real arrow shooting. Afterward, we compared percentage changes between VR and real archery., Results: Results showed that HR and root mean square of successive differences (RMMSD) were significantly higher during real archery compared to virtual archery. In addition, VR archery led to a greater percentage change in RMSSD compared to real archery. Participants reported greater RPE and perceived difficulty after real archery. Performance was also higher during VR archery than real archery., Conclusions: Consequently, the results of the present study illustrated that VR, and real archery might lead to different autonomic response patterns in terms of vagal activity., (© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
39. Assessing Frailty, Rational Use of Medications, and Adherence to Immunosuppressive Therapy in Liver Transplant Recipients.
- Author
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Kömürkara S, Cengiz Z, and Tok S
- Subjects
- Humans, Female, Male, Cross-Sectional Studies, Middle Aged, Adult, Transplant Recipients, Surveys and Questionnaires, Aged, Liver Transplantation, Immunosuppressive Agents therapeutic use, Frailty, Medication Adherence statistics & numerical data
- Abstract
Aim: The study was conducted to determine the level of frailty, rational medication use, and adherence to immunosuppressive therapy in liver transplant patients and to examine the relationships among them., Materials and Methods: The data of the descriptive cross-sectional study were collected between January 2023 and September 2023. Our study included 200 liver transplant recipients. In addition to demographic and medical characteristics, frailty status, rational drug use, and compliance with immunosuppressive therapy were measured in a 15-20 minute questionnaire administration period., Results: The frailty scores of liver transplant patients were 2.11 ± 1.34, rational drug use scores were 82.88 ± 13.11, and compliance with immunosuppressive therapy scores were 11.12 ± 1.07. The scores for rational drug use and adherence to immunosuppressive therapy were not affected by frailty status, and patients used drugs rationally and adhered to immunosuppressive therapy even when they were frail. It was found that the vulnerability status of the participants was affected by gender and occupational variables, most patients were in the vulnerable group in women and men, and those who did not work were more vulnerable than the other groups., Conclusion: It was found that liver transplant patients were frail, and frailty did not affect the level of rational drug use and compliance with immunosuppressive therapy., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
- Full Text
- View/download PDF
40. Detection and phylogenetic analysis of contemporary H14N2 Avian influenza A virus in domestic ducks in Southeast Asia (Cambodia).
- Author
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Siegers JY, Wille M, Yann S, Tok S, Sin S, Chea S, Porco A, Sours S, Chim V, Chea S, Chhel K, Tum S, Sorn S, Hak M, Thielen P, Dhanasekaran V, and Karlsson EA
- Subjects
- Animals, Ducks, Cambodia, Phylogeny, Birds, Animals, Wild, Poultry, Influenza in Birds, Influenza A virus genetics
- Abstract
Avian influenza virus (AIV) in Asia is a complex system with numerous subtypes and a highly porous wild birds-poultry interface. Certain AIV subtypes, such as H14, are underrepresented in current surveillance efforts, leaving gaps in our understanding of their ecology and evolution. The detection of rare subtype H14 in domestic ducks in Southeast Asia comprises a geographic region and domestic bird population previously unassociated with this subtype. These H14 viruses have a complex evolutionary history involving gene reassortment events. They share sequence similarity to AIVs endemic in Cambodian ducks, and Eurasian low pathogenicity and high pathogenicity H5Nx AIVs. The detection of these H14 viruses in Southeast Asian domestic poultry further advances our knowledge of the ecology and evolution of this subtype and reinforces the need for continued, longitudinal, active surveillance in domestic and wild birds. Additionally, in vivo and in vitro risk assessment should encompass rare AIV subtypes, as they have the potential to establish in poultry systems.
- Published
- 2024
- Full Text
- View/download PDF
41. The effect of background audio and audiovisual stimuli on students' autonomic responses during and after an experimental academic examination.
- Author
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Balıkçı İ, Tok S, and Binboğa E
- Subjects
- Humans, Autonomic Nervous System physiology, Communicable Disease Control, Heart Rate physiology, Pandemics, Students, COVID-19, Music
- Abstract
Background: Due to the Covid-19 pandemic lockdown during the online-distant education period, certain students tended to combine their courses and homework with TV or social media news or other media content, such as classical music, including a wealth of audio and audiovisual stimuli. As the audio and audiovisual stimuli existing in a learning environment may affect students' autonomic nervous system (ANS) responses negatively, the present study aimed to monitor the impact of background TV, classical music, and silence on students' ANS activity represented by heart rate (HR), heart rate variability (HRV), blood volume amplitude (BVA), and skin conductance level (SCL) during and after an experimental academic examination., Method: Seventy-six students were randomly allocated to background TV, classical music, or silence groups. The experiment with repeated measures design consisted of four consecutive periods: baseline, anticipation, challenge, and recovery, lasting 4 min each., Results: Within-subject analyses indicated significant HRV decrement only in the background TV group. Regardless of the experimental groups, HR and SCL increased while BVA decreased during the task. In addition, the between-subject analysis showed that the background TV group experienced significantly larger changes in HR and HRV parameters compared to the other experimental groups relative to their respective baseline measurements., Conclusions: Based on these results, we concluded that relative to classical music and silence, background TV, including audiovisual and verbal stimuli, extant in a learning environment might raise students' sympathetic activity. Further, classical music, without lyrics, may suppress the withdrawal of vagal activity and elevate the autonomic regulation capacity during the academic reading comprehension task. HRV is a more valid and reliable indicator of students' autonomic responses during a challenging academic task., (© 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
- Published
- 2023
- Full Text
- View/download PDF
42. Emerging Increase in Colistin Resistance Rates in Escherichia coli and Salmonella enterica from Türkiye.
- Author
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Tok S, Guzel M, and Soyer Y
- Subjects
- Colistin, Escherichia coli, Anti-Bacterial Agents, Microbial Sensitivity Tests, Salmonella enterica, Escherichia coli Proteins
- Abstract
Foodborne infections caused by drug-resistant Salmonella spp. are a global health concern. Moreover, commensal Escherichia coli is considered risky due to the presence of antimicrobial resistance genes. Colistin is considered a last-resort antibiotic against Gram-negative bacterial infections. Colistin resistance can be transferred both vertically, and horizontally via conjugation between bacterial species. Plasmid-mediated resistance has been associated with mcr-1 to mcr-10 genes. In this study, we collected food samples (n = 238), and isolated E. coli (n = 36) and Salmonella (n = 16), representing recent isolates. We included previously collected Salmonella (n = 197) and E. coli (n = 56) from various sources from 2010 to 2015 in Türkiye as representing historical isolates to investigate colistin-resistance over time. In all isolates, colistin resistance was screened phenotypically by minimum inhibitory concentration (MIC), and then in resistant isolates, mcr-1 to mcr-5 genes were further screened. In addition, the antibiotic resistance of recent isolates was determined, and antibiotic resistance genes were investigated. We found that in total 20 Salmonella isolates (9.38%) and 23 of the E. coli isolates (25%) showed phenotypic colistin resistance. Interestingly, the majority of colistin-resistant isolates (N:32) had resistance levels above 128 mg/L. Furthermore 75% of commensal E. coli isolates recently isolated were resistant at least 3 antibiotics. Overall, we found that the colistin resistance has been increased from 8.12 to 25% in Salmonella isolates, and 7.14% to 52.8% in E. coli isolates over time. However, none of these resistant isolates carried mcr genes, most likely indicating emerging chromosomal colistin resistance., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
43. Aerosol exposure of live bird market workers to viable influenza A/H5N1 and A/H9N2 viruses, Cambodia.
- Author
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Horwood PF, Horm SV, Yann S, Tok S, Chan M, Suttie A, Y P, Rith S, Siegers JY, San S, Davun H, Tum S, Ly S, Tarantola A, Dussart P, and Karlsson EA
- Subjects
- Animals, Humans, Cambodia epidemiology, Respiratory Aerosols and Droplets, Chickens, Phylogeny, Influenza, Human epidemiology, Influenza A Virus, H9N2 Subtype genetics, Influenza in Birds epidemiology, Influenza A Virus, H5N1 Subtype
- Abstract
Live bird markets (LBMs) have been identified as key factors in the spread, persistence and evolution of avian influenza viruses (AIVs). In addition, these settings have been associated with human infections with AIVs of pandemic concern. Exposure to aerosolised AIVs by workers in a Cambodian LBM was assessed using aerosol impact samplers. LBM vendors were asked to wear an air sampler for 30 min per day for 1 week while continuing their usual activities in the LBM during a period of high AIV circulation (February) and a period of low circulation (May). During the period of high circulation, AIV RNA was detected from 100% of the air samplers using molecular methods and viable AIV (A/H5N1 and/or A/H9N2) was isolated from 50% of air samplers following inoculation into embryonated chicken eggs. In contrast, AIV was not detected by molecular methods or successfully isolated during the period of low circulation. This study demonstrates the increased risk of aerosol exposure of LBM workers to AIVs during periods of high circulation and highlights the need for interventions during these high-risk periods. Novel approaches, such as environmental sampling, should be further explored at key high-risk interfaces as a potentially cost-effective alternative for monitoring pandemic threats., (© 2022 The Authors. Zoonoses and Public Health published by Wiley-VCH GmbH.)
- Published
- 2023
- Full Text
- View/download PDF
44. Is there a correlation between the femoral anteversion angle and the elasticity of the hip muscles in cases of intoeing gait due to increased femoral anteversion angle?
- Author
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Urfali FE, Tok S, Kuyubaşi SN, İnal S, and Korkmaz M
- Abstract
Purpose: One of the common causes of gait disturbance in children is increased femoral anteversion. There are not enough publications in the literature on muscles related to the hip joint in increased femoral anteversion. The aim of this study was to evaluate the relationship between the femoral anteversion angle and hip muscle elasticity in children walking inward, using shear wave elastography (SWE)., Material and Methods: Seventeen children with bilateral increased femoral anteversion angle in computed tomography were prospectively included in this study. Elasticity values of the hip muscles (adductor magnus (adductor), iliopsoas (flexor), gluteus medius (abductor), gluteus maximus (extensor) muscles) were evaluated by ultrasound elastography by two observers. Quantitative measurements of the shear wave velocities were performed using virtual touch tissue imaging quantification., Results: There was excellent harmony between the femoral anteversion angle measurements performed by the two observers and a good congruence between the muscle elastography evaluations. While there was a moderate significant correlation between the femoral anteversion angle and the elasticity values of the iliopsoas and adductor magnus muscles, no significant correlation was found with other muscle elasticity measurements., Conclusion: Iliopsoas muscle and adductor magnus muscle elasticity are correlated with the femoral anteversion angle. With further studies, we think that physical therapy methods for the elasticity of the muscles associated with the femoral anteversion angle can reduce the complaints of the patients., Competing Interests: The authors do not report any financial or personal connections with other persons or organi-zations which might negatively affect the contents of this publication and/or claim authorship rights to this publication., (2022 Polish Ultrasound Society. Published by Medical Communications Sp. z o.o. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
45. Functional Neurophysiological Biomarkers of Early-Stage Alzheimer's Disease: A Perspective of Network Hyperexcitability in Disease Progression.
- Author
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Tok S, Ahnaou A, and Drinkenburg W
- Subjects
- Amyloid beta-Peptides therapeutic use, Animals, Biomarkers, Disease Progression, Humans, Neurophysiology, tau Proteins, Alzheimer Disease pathology, Nervous System Physiological Phenomena
- Abstract
Network hyperexcitability (NH) has recently been suggested as a potential neurophysiological indicator of Alzheimer's disease (AD), as new, more accurate biomarkers of AD are sought. NH has generated interest as a potential indicator of certain stages in the disease trajectory and even as a disease mechanism by which network dysfunction could be modulated. NH has been demonstrated in several animal models of AD pathology and multiple lines of evidence point to the existence of NH in patients with AD, strongly supporting the physiological and clinical relevance of this readout. Several hypotheses have been put forward to explain the prevalence of NH in animal models through neurophysiological, biochemical, and imaging techniques. However, some of these hypotheses have been built on animal models with limitations and caveats that may have derived NH through other mechanisms or mechanisms without translational validity to sporadic AD patients, potentially leading to an erroneous conclusion of the underlying cause of NH occurring in patients with AD. In this review, we discuss the substantiation for NH in animal models of AD pathology and in human patients, as well as some of the hypotheses considering recently developed animal models that challenge existing hypotheses and mechanisms of NH. In addition, we provide a preclinical perspective on how the development of animal models incorporating AD-specific NH could provide physiologically relevant translational experimental data that may potentially aid the discovery and development of novel therapies for AD.
- Published
- 2022
- Full Text
- View/download PDF
46. Is female urge associated with incontinence, somatosensory amplification, health anxiety and depression?
- Author
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Firat F, Oztekin U, Tokpinar A, Caniklioglu M, Gürtan E, Tok S, and Halis F
- Subjects
- Adult, Anxiety, Anxiety Disorders, Female, Humans, Middle Aged, Psychiatric Status Rating Scales, Depression etiology, Urinary Incontinence
- Abstract
Purpose: Incontinence is a condition that can cause significant problems that can affect patients' quality of social, emotional, psychological and sexual life. The aim of this study was to evaluate the level of anxiety, health anxiety, depression and somatosensory amplification in patients with urge incontinence., Materials and Methods: The study group consisted of 58 patients that met the inclusion criteria. The control group consisted of 67 volunteer participants that did not have physical or psychiatric illness and incontinence complaints. All participants filled out sociodemographic data form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Somatosensory Amplification Scale (SSAS) and Health Anxiety Inventory (HAI)., Results: The mean duration of incontinence in patients with urge incontinence was 16.55 ± 10.03 months. The mean age in urge incontinence group and the control group were 40.98 ± 9.58 and 39.1 ± 7.89 years, respectively. The mean values of SSAS, HAI and BAI scores in the incontinence group were significantly higher than the control group (P < .001), but there was no significant difference between the groups in terms of BDI scores. The linear regression analysis indicated that HAI and BAI significantly affected SSAS (P = .025 and 0.019, respectively)., Conclusions: Anxiety, health anxiety and somatosensory amplification are more common in patients who report urge incontinence. For these reasons, we believe that psychiatric evaluation should be included in the diagnosis and treatment process of patients presenting with urgency and incontinence symptoms., (© 2021 John Wiley & Sons Ltd.)
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- 2021
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47. Ultrasonography in soft-tissue foreign-body detection: a phantom study.
- Author
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Tok S and Kadioglu E
- Abstract
Purpose: Foreign body implantation into the soft tissues, either in the early period or late period, is a common cause of emergency department admissions. Direct X-rays are preferred in the diagnosis of soft-tissue foreign-bodies. Herein, we aimed to analyse the detection rates of foreign bodies of various sizes placed in phantoms implanted into soft tissue by ultrasonography., Material and Methods: A total of 740 pieces of chicken fillet were prepared as phantoms. No objects were implanted into 100 phantoms. We inserted glass, porcelain, plastic, wood, pencil tip, chicken bone, iron, walnut shell, and fishbone with a length of < 1 cm, 1-3 cm, and 3-5 cm into 20 pieces of chicken phantom in each size of foreign body (FB). In addition, 1-3 cm long peanut shell, < 1 cm rose spikes, < 1 cm cactus thorns, < 1 cm pellets, and < 1 cm staples were inserted into 20 pieces of chicken for each object. Each of the chicken pieces was placed inside a latex glove and examined by ultrasonography., Results: The sensitivity of ultrasonography in the detection of the cactus thorn was 5%, whereas it ranged between 82.5 and 100% for other objects. For glass, plastic, wood, iron, and fishbone, we found that when the size exceeded 1 cm, the sensitivity increased., Conclusions: In the evaluation of soft tissue FBs, as the size of the FBs increases, the diagnostic value of ultrasonography increases., Competing Interests: The authors report no conflict of interest., (© Pol J Radiol 2021.)
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- 2021
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48. The Short-Term Effect of Occupational Levels of 50 Hz Electromagnetic Field on Human Heart Rate Variability.
- Author
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Binboğa E, Tok S, and Munzuroğlu M
- Subjects
- Double-Blind Method, Heart Rate, Humans, Male, Electromagnetic Fields adverse effects
- Abstract
Previous studies have indicated that there is no consensus on the effects of extremely low-frequency electromagnetic (ELF-EMF) exposure on the cardiovascular system. This study aimed to explore the short-term effect of ELF-EMF exposure on heart rate (HR) and HR variability (HRV). The sample consisted of 34 healthy males aged 18-27 years. The participants were randomly assigned to the EMF (n = 17) or the Sham group (n = 17). We employed a double-blind repeated-measures design consisting of three 5 min experimental periods. The chest region of each individual in the EMF group was exposed to 50 Hz, 28 μT, linear polarized, continuous EMF during the EMF exposure period. HR and HRV data were recorded continuously by using a photoplethysmography sensor. Within-subject statistical analysis indicated a significant HR deceleration in both the EMF and Sham groups. However, the standard deviation of the NN intervals (SDNN), root mean square of successive differences (RMSSD), low-frequency (LF), and high-frequency (HF) powers increased only in the EMF group and remained stable in the Sham group. We also compared the same HRV indices measured during the EMF and Sham periods between the two experimental groups. The between-subject analysis results demonstrated significantly higher SDNN, RMSSD, LF, and HF values in the EMF group than in the Sham group. The LF/HF ratio did not change significantly within and between groups. On the basis of these results, we concluded that short-term exposure of the chest region to ELF-EMF could potentially enhance parasympathetic predominance during the resting condition. Bioelectromagnetics. 2021;42:60-75. © 2020 Bioelectromagnetics Society., (© 2020 Bioelectromagnetics Society.)
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- 2021
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49. Transmission experiments support clade-level differences in the transmission and pathogenicity of Cambodian influenza A/H5N1 viruses.
- Author
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Horwood PF, Fabrizio T, Horm SV, Metlin A, Ros S, Tok S, Jeevan T, Seiler P, Y P, Rith S, Suttie A, Buchy P, Karlsson EA, Webby R, and Dussart P
- Subjects
- Animals, Cambodia epidemiology, Humans, Influenza in Birds epidemiology, Influenza in Birds transmission, Influenza, Human epidemiology, Influenza, Human transmission, Orthomyxoviridae Infections epidemiology, Phylogeny, Species Specificity, Virulence, Chickens virology, Ducks virology, Ferrets virology, Influenza A Virus, H5N1 Subtype classification, Influenza A Virus, H5N1 Subtype pathogenicity, Orthomyxoviridae Infections transmission
- Abstract
Influenza A/H5N1 has circulated in Asia since 2003 and is now enzootic in many countries in that region. In Cambodia, the virus has circulated since 2004 and has intermittently infected humans. During this period, we have noted differences in the rate of infections in humans, potentially associated with the circulation of different viral clades. In particular, a reassortant clade 1.1.2 virus emerged in early 2013 and was associated with a dramatic increase in infections of humans (34 cases) until it was replaced by a clade 2.3.2.1c virus in early 2014. In contrast, only one infection of a human has been reported in the 6 years since the clade 2.3.2.1c virus became the dominant circulating virus. We selected three viruses to represent the main viral clades that have circulated in Cambodia (clade 1.1.2, clade 1.1.2 reassortant, and clade 2.3.2.1c), and we conducted experiments to assess the virulence and transmissibility of these viruses in avian (chicken, duck) and mammalian (ferret) models. Our results suggest that the clade 2.3.2.1c virus is more "avian-like," with high virulence in both ducks and chickens, but there is no evidence of aerosol transmission of the virus from ducks to ferrets. In contrast, the two clade 1 viruses were less virulent in experimentally infected and contact ducks. However, evidence of chicken-to-ferret aerosol transmission was observed for both clade 1 viruses. The transmission experiments provide insights into clade-level differences that might explain the variation in A/H5N1 infections of humans observed in Cambodia and other settings.
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- 2020
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50. Autonomic Cardiac Activity Among Novice Archers During Baseline, Shooting, and Recovery.
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Tok S, Dal N, Zekioğlu A, Çatıkkaş F, Balıkçı İ, and Doğan E
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- Adult, Analysis of Variance, Female, Humans, Male, Young Adult, Autonomic Nervous System physiology, Heart Rate physiology, Sports physiology
- Abstract
Tok, S, Dal, N, Zekioğlu, A, Çatıkkaş, F, Balıkçı, İ, and Doğan, E. Autonomic cardiac activity among novice archers during baseline, shooting and recovery. J Strength Cond Res 34(9): 2627-2635, 2020-In the present study, we aimed to investigate whether heart rate variability (HRV) of novice archers may vary during baseline, shooting, and recovery periods. In addition, we aimed to explore whether HRV may have different patterns between successful and less successful archers and man and woman archers. The sample consisted of 39 (12 woman) novice archers ranging in age from 21 to 27. Baseline HRV activity was measured in the first stage of the experiment. Then, participants shot 10 arrows, from 18 m to an 80 cm diameter target, whereas their HRV was measured. Lastly, HRV recovery response was measured immediately after shooting. HRV was represented as low frequency (LF), high frequency (HF), and LF/HF ratio. When considering the entire sample, repeated measures of analysis of variance (ANOVA) indicated that only HF power differed among baseline, shooting, and recovery periods [F(2, 76) = 6.90, p = 0.002, ω = 0.15]. When the data partitioned, based on the median split of the shooting scores, repeated measures of ANOVA demonstrated that none of the HRV components differed in the less successful group from baseline to recovery. However, in the successful group, both LF [F(1.47, 30.98) = 4.75, p = 0.024, ω = 0.18] and HF [F(1.54, 32.37) = 6.61, p = 0.007, ω = 0.24] power significantly differed among baseline, shooting, and recovery. No differences were found between man and woman archers in terms of HRV indices. The results of the present study indicated that physical activities requiring the use of perceptual motor skills, in addition to physical qualities, may lead to different HRV responses. Moreover, coaches aiming to develop archers' shooting accuracy may take into account LF power measured during an arrow shooting session.
- Published
- 2020
- Full Text
- View/download PDF
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