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179 results on '"Tojal-Sierra, Lucas"'

1. Sex-specific dietary patterns and their association with metabolic syndrome: Insights from a cross-sectional analysis

Author: Popescu, Mónica Lavinia, Rubín-García, María, Álvarez-Álvarez, Laura, Toledo, Estefanía, Corella, Dolores, Salas-Salvadó, Jordi, Pérez-Vega, Karla Alejandra, Martínez, J Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Cano-Ibáñez, Naomi, Tur, Josep A., Naveiro, Roi, Pintó, Xavier, Delgado-Rodríguez, Miguel, Ortiz-Ramos, María, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Vázquez-Ruiz, Zenaida, Babio, Nancy, Sorlí, Jose V., Castañer, Olga, García-Rios, Antonio, González-Palacios, Sandra, Zulet, María, Konieczna, Jadwiga, Casas, Rosa, Masso-Guijarro, Paloma, Tojal-Sierra, Lucas, Gómez-Pérez, Ana M., Cenoz-Osinaga, Juan Carlos, Valverde, Irene, Fernández-Carrión, Rebeca, Schröder, Helmut, Arenas Larriva, Antonio P., Torres-Collado, Laura, García-Arellano, Ana, Palau-Galindo, Antoni, Fitó, Montserrat, Martín-Sánchez, Vicente, and Fernández-Villa, Tania
Published: 2024
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2. Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population

Author: Khoury, Nadine, Ángeles Martínez, María, Nishi, Stephanie K., Ángel Martínez-González, Miguel, Corella, Dolores, Castañer, Olga, Alfredo Martínez, J., Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Manuel Santos-Lozano, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Cinza Sanjurjo, Sergio, Pintó, Xavier, Juan Gaforio, José, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, V Sorli, Jose, Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Ortiz-Díaz, Francisco, Gómez-Gracia, Enrique, Zulet, MA, Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vazquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, and Salas-Salvadó, Jordi
Published: 2024
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3. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Author: Shyam, Sangeetha, García-Gavilán, Jesús Francisco, Paz-Graniel, Indira, Gaforio, José J., Martínez-González, Miguel Ángel, Corella, Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sánchez, Vicente Martín, Pintó, Xavier, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Fernandez-Aranda, Fernando, Nishi, Stephanie K., Garcia-Regata, Oscar, Toledo, Estefania, Asensio, Eva M., Castañer, Olga, Garcia-Rios, Antonio, Torres-Collado, Laura, Gómez-Gracia, Enrique, Zulet, M. Angeles, Ruiz, Nuria Goñi, Casas, Rosa, Cano-Ibáñez, Naomi, Tojal-Sierra, Lucas, Gómez-Perez, A. M., Sorlí, Jose V., Cinza-Sanjurjo, Sergio, Martín-Peláez, Sandra, Peña-Orihuela, Patricia J., Oncina-Canovas, Alejandro, Perez-Araluce, Rafael, Zomeño, María Dolores, Chaplin, Alice, Delgado-Rodríguez, Miguel, Babio, Nancy, Fitó, Montserrat, and Salas-Salvadó, Jordi
Published: 2023
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4. Ultra-processed foods consumption as a promoting factor of greenhouse gas emissions, water, energy, and land use: A longitudinal assessment

Author: García, Silvia, Pastor, Rosario, Monserrat-Mesquida, Margalida, Álvarez-Álvarez, Laura, Rubín-García, María, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, J. Alfredo, Tojal-Sierra, Lucas, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José Manuel, Serra-Majem, Lluís, Cano-Ibañez, Naomi, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Buil-Cosiales, Pilar, Martínez-Rodríguez, María Ángeles, Coltell, Oscar, Castañer, Olga, Garcia-Rios, Antonio, Barceló, Concepción, Gómez-Gracia, Enrique, Zulet, Maria Ángeles, Konieczna, Jadwiga, Casas, Rosa, Massó-Guijarro, Paloma, Goicolea-Güemez, Leire, Bernal-López, María Rosa, Bes-Rastrollo, Maira, Shyam, Sangeetha, González, José I., Zomeño, María Dolores, Peña-Orihuela, Patricia J., González-Palacios, Sandra, Toledo, Estefanía, Khoury, Nadine, Perez, Karla Alejandra, Martín-Sánchez, Vicente, Tur, Josep A., and Bouzas, Cristina
Published: 2023
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5. Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study

Author: Ni, Jiaqi, Nishi, Stephanie K., Babio, Nancy, Ros, Emilio, Basterra-Gortari, F Javier, Corella, Dolores, O, Castañer, Martínez, J Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José Manuel, Serra-Majem, Lluís, Cano-Ibáñez, Naomi, Tur, Josep A., Fernández-García, José Manuel, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández-Aranda, Fernando, Ruiz-Canela, Miguel, Mestres Solà, Cristina, Portolés, Olga, Sala-Vila, Aleix, Garcia-Rios, Antonio, Compañ-Gabucio, Laura María, Gómez-Gracia, Enrique, Zulet, M Angeles, Chaplin, Alice, Casas, Rosa, Martínez-Diz, Silvia, Tojal-Sierra, Lucas, Gómez-Pérez, Ana María, Toledo, Estefanía, Rios, Santiago, Ortega-Azorín, Carolina, de la Torre, Rafael, Peña-Orihuela, Patricia J., Garcia-de la Hera, Manuela, Sayón-Orea, Carmen, Malcampo, Mireia, and Salas-Salvadó, Jordi
Published: 2023
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6. Increased ultra-processed food consumption is associated with worsening of cardiometabolic risk factors in adults with metabolic syndrome: Longitudinal analysis from a randomized trial

Author: González-Palacios, Sandra, Oncina-Cánovas, Alejandro, García-de-la-Hera, Manuela, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Cano-Ibañez, Naomi, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Bes-Rastrollo, Maira, Atzeni, Alessandro, Sorli, Jose V., Zomeño, M. Dolors, Peña-Orihuela, Patricia J., Compañ-Gabucio, Laura M., Barón-López, Francisco J., Zulet, María Ángeles, Konieczna, Jadwiga, Casas, Rosa M., Garrido-Garrido, Eva M., Tojal-Sierra, Lucas, Gomez-Perez, Ana M., Ruiz-Canela, Miguel, Palau, Antoni, Saiz, Carmen, Pérez-Vega, Karla A., Garcia-Rios, Antonio, Torres-Collado, Laura, Basterra-Gortari, Javier, Garcidueñas-Fimbres, Tany E., Malcampo, Mireia, and Vioque, Jesús
Published: 2023
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7. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.

Author: Khoury, Nadine, Martínez, María Ángeles, Paz-Graniel, Indira, Martínez-González, Miguel Ángel, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sanjurjo, Sergio Cinza, Pintó, Xavier, Gaforio, José Juan, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Sorlí, Jose V., Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Bellvert, Nuria Gómez, Gómez-Gracia, Enrique, Zulet, M.A., Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vázquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, and Salas-Salvadó, Jordi
Published: 2023
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8. Comparative effects of glucagon-like peptide-1 receptors agonists, 4-dipeptidyl peptidase inhibitors, and metformin on metabolic syndrome

Author: Bouzas, Cristina, Pastor, Rosario, Garcia, Silvia, Monserrat-Mesquida, Margalida, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Fernández-Barceló, Olga, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Riquelme-Gallego, Blanca, Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodriguez, Miguel, Matía, Pilar, Vidal, Josep, Cardenas-Salas, Jersy-Jair, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Manzanares, Josep M., Gonzalez-Monge, Inmaculada, Muñoz, Miguel-Ángel, Martinez-Urbistondo, Diego, Tojal-Sierra, Lucas, Muñoz-Bravo, Carlos, Miralles-Gisbert, Salvador, Martin, Marian, García-Ríos, Antonio, Castro-Barquero, Sara, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Basterra-Gortari, F. Javier, Gutiérrez-Carrasquilla, Liliana, Guillem-Saiz, Patricia, Satorres, Alba, Abete, Itziar, Sorto-Sanchez, Carolina, Díez-Espino, Javier, Babio, Nancy, Fitó, Montse, and Tur, Josep A.
Published: 2023
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9. One-year changes in fruit and vegetable variety intake and cardiometabolic risk factors changes in a middle-aged Mediterranean population at high cardiovascular risk

Author: López-González, Leyre, Becerra-Tomás, Nerea, Babio, Nancy, Martínez-González, Miguel Ángel, Nishi, Stephanie K., Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Vázquez-Ruiz, Zenaida, Martín-Luján, Francisco M., Sorlí, José V., Castañer, Olga, Zulet, M. Angeles, Tojal-Sierra, Lucas, Carabaño-Moral, Rosa, Román-Maciá, Josefa, Rayó, Elena, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana M., Santos-Lozano, José M., Buil-Cosiales, Pilar, Asensio, Eva M., Lassale, Camille, Abete, Itziar, Salaverria-Lete, Itziar, Sayón-Orea, Carmen, Schröder, Helmut, and Salas-Salvadó, Jordi
Published: 2022
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10. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

Author: Díez-Ricote, Laura, San-Cristobal, Rodrigo, Concejo, M José, Martínez-González, Miguel Á, Corella, Dolores, Salas-Salvadó, Jordi, Goday, Albert, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A, Martín Sánchez, Vicente, Pintó, Xavier, Gaforio, José J, Matía-Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Ros, Emilio, Vázquez-Ruiz, Zenaida, Ortega-Azorín, Carolina, García-Gavilán, Jesús F, Malcampo, Mireia, Martínez-Urbistondo, Diego, Tojal-Sierra, Lucas, García Rodríguez, Antonio, Gómez-Bellvert, Nuria, Chaplin, Alice, García-Ríos, Antonio, Bernal-López, Rosa M, Santos-Lozano, José M, Basterra-Gortari, Javier, Sorlí, José V, Murphy, Michelle, Gasulla, Griselda, Micó, Víctor, Salaverria-Lete, Itziar, Goñi Ochandorena, Estibaliz, Babio, Nancy, Herraiz, Xavier, Ordovás, José M, and Daimiel, Lidia
Published: 2022
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11. Association of Left Atrial Structure and Function With Cognitive Function in Adults With Metabolic Syndrome

Author: Gonzalez Casanova, Ines, Alonso-Gómez, Ángel M., Romaguera, Dora, Toledo, Estefanía, Fortuny, Elena, López, Luis, Ramallal, Raúl, Salas-Salvadó, Jordi, Tojal-Sierra, Lucas, Castañer, Olga, and Alonso, Alvaro
Published: 2022
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12. Polyphenol intake and cardiovascular risk in the PREDIMED-Plus trial. A comparison of different risk equations

Author: Rubín-García, María, Vitelli-Storelli, Facundo, Toledo, Estefanía, Castro-Barquero, Sara, Tresserra-Rimbau, Anna, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Álvarez-Álvarez, Laura, Pintó, Xavier, Gaforio, José J., Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Gea, Alfredo, Manzanares, José María, Sorlí, Jose V., Schröder, Helmut, Abete, Itziar, Tojal-Sierra, Lucas, Crespo-Oliva, Edelys, González-Botella, Andrés, Rayó, Elena, García-Rios, Antonio, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Bartolomé Resano, Rafael, Murphy, Michelle M., Ortega-Azorin, Carolina, Medrano, Casimira, Zulet, María Ángeles, Sorto-Sanchez, Carolina, Babio, Nancy, Fitó, Montserrat, Lamuela-Raventós, Rosa María, and Martín-Sánchez, Vicente
Published: 2022
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13. Ingesta de polifenoles y riesgo cardiovascular en el ensayo PREDIMED-Plus. Una comparación de diferentes ecuaciones de riesgo

Author: Rubín-García, María, Vitelli-Storelli, Facundo, Toledo, Estefanía, Castro-Barquero, Sara, Tresserra-Rimbau, Anna, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Álvarez-Álvarez, Laura, Pintó, Xavier, Gaforio, José J., Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Gea, Alfredo, Manzanares, José María, Sorlí, Jose V., Schröder, Helmut, Abete, Itziar, Tojal-Sierra, Lucas, Crespo-Oliva, Edelys, González-Botella, Andrés, Rayó, Elena, García-Rios, Antonio, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Bartolomé Resano, Rafael, Murphy, Michelle M., Ortega-Azorin, Carolina, Medrano, Casimira, Zulet, María Ángeles, Sorto-Sanchez, Carolina, Babio, Nancy, Fitó, Monstserrat, Lamuela-Raventós, Rosa María, and Martín-Sánchez, Vicente
Published: 2022
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14. Factors associated with successful dietary changes in an energy-reduced Mediterranean diet intervention: a longitudinal analysis in the PREDIMED-Plus trial

Author: Fernandez-Lazaro, Cesar I., Toledo, Estefanía, Buil-Cosiales, Pilar, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Ros, Emilio, Vázquez, Clotilde, Daimiel, Lidia, SanJulián, Beatriz, García-Gavilán, Jesús F., Sorlí, Jose V., Castañer, Olga, Zulet, M. Ángeles, Tojal-Sierra, Lucas, Pérez-Farinós, Napoleón, Oncina-Canovas, Alejandro, Moñino, Manuel, Garcia-Rios, Antonio, Sacanella, Emilio, Bernal-Lopez, Rosa M., Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Muralidharan, Jananee, Ortega-Azorín, Carolina, Goday, Alberto, Razquin, Cristina, Goicolea-Güemez, Leire, Ruiz-Canela, Miguel, Becerra-Tomás, Nerea, Schröder, Helmut, and Martínez González, Miguel A.
Published: 2022
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15. Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF)

Author: Martinez-Perez, Celia, Daimiel, Lidia, Climent-Mainar, Cristina, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martinez, Jose Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluis, Bueno-Cavanillas, Aurora, Tur, Josep A., Sánchez, Vicente Martín, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Javier, Babio, Nancy, Guillem-Saiz, Patricia, Zomeño, María Dolores, Abete, Itziar, Vaquero-Luna, Jessica, Barón-López, Francisco Javier, Gonzalez-Palacios, Sandra, Konieczna, Jadwiga, Garcia-Rios, Antonio, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Bes-Rastrollo, Maira, Khoury, Nadine, Saiz, Carmen, Pérez-Vega, Karla Alejandra, Zulet, María Angeles, Tojal-Sierra, Lucas, Ruiz, Zenaida Vázquez, Martinez, Maria Angeles, Malcampo, Mireia, Ordovás, José M., and San-Cristobal, Rodrigo
Published: 2022
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16. Physical activity and metabolic syndrome severity among older adults at cardiovascular risk: 1-Year trends

Author: Gallardo-Alfaro, Laura, Bibiloni, Maria del Mar, Bouzas, Cristina, Mascaró, Catalina M., Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Micó, Rafael M., Pintó, Xavier, Gaforio, José J., Ortíz-Ramos, María, Altés-Boronat, Andreu, Luca, Bogdana L., Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Becerra-Tomás, Nerea, Gimenez-Alba, Ignacio Manuel, Castañer, Olga, Abete, Itziar, Tojal-Sierra, Lucas, Pérez-López, Jéssica, Torres-Collado, Laura, Colom, Antoni, Garcia-Rios, Antonio, Castro-Barquero, Sara, Bernal, Rosa, Santos-Lozano, José Manuel, Fernandez-Lazaro, Cesar I., Hernández-Alonso, Pablo, Saiz, Carmen, Zomeño, Maria Dolors, Zulet, Maria Angeles, Belló-Mora, Maria C., Basterra-Gortari, F. Javier, Canudas, Silvia, Goday, Albert, and Tur, Josep A.
Published: 2021
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17. Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis

Author: Becerra-Tomás, Nerea, Paz-Graniel, Indira, Tresserra-Rimbau, Anna, Martínez-González, Miguel Á., Barrubés, Laura, Corella, Dolores, Muñoz-Martínez, Júlia, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, José A., Serra-Majem, Luís, Estruch, Ramon, Bernal-López, Maria R., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Riquelme Gallego, Blanca, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Velilla-Zancada, Sonsoles, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Babio, Nancy, Fernández-Carrión, Rebeca, Pérez-Vega, Karla A., Morey, Marga, Torres-Collado, Laura, Tojal-Sierra, Lucas, Pérez-López, Jessica, Abete, Itziar, Cabrera, Judith P., Casas, Rosa, Fernández-García, José C., Santos-Lozano, José M., Esteve-Luque, Virginia, Bouzas, Cristina, Fernandez-Lazaro, Cesar I., Sorlí, José V., Freixer, Gala, Martín, Marian, Muñoz, Montserrat G., Salaverria-Lete, Itziar, Toledo, Estefania, Castañer, Olga, and Salas-Salvadó, Jordi
Published: 2021
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18. Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study

Author: Julibert, Alicia, del Mar Bibiloni, Maria, Gallardo-Alfaro, Laura, Abbate, Manuela, Martínez-González, Miguel Á, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montse, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluís, Cano-Ibañez, Naomi, Martín-Sánchez, Vicente, Pintó, Xavier, Gaforio, José J, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Becerra-Tomás, Nerea, Gimenez-Alba, Ignacio M, Castañer, Olga, Abete, Itziar, Tojal-Sierra, Lucas, Pérez-López, Jéssica, Notario-Barandiaran, Leyre, Colom, Antoni, Garcia-Rios, Antonio, Castro-Barquero, Sara, Bernal, Rosa, Santos-Lozano, José M, Fernández-Lázaro, Cesar I, Hernández-Alonso, Pablo, Saiz, Carmen, Zomeño, Maria D, Zulet, Maria A, Belló-Mora, Maria C, Basterra-Gortari, Javier, Canudas, Silvia, Goday, Albert, and Tur, Josep A
Published: 2020
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19. Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk

Author: Alam, Aniqa B., primary, Toledo‐Atucha, Estefania, additional, Romaguera, Dora, additional, Alonso‐Gómez, Angel M., additional, Martínez‐Gonzalez, Miguel A., additional, Tojal‐Sierra, Lucas, additional, Mora, Marta Noris, additional, Mas‐Llado, Caterina, additional, Li, Linzi, additional, Gonzalez‐Casanova, Ines, additional, Salas‐Salvadó, Jordi, additional, Fitó, Montserrat, additional, and Alonso, Alvaro, additional
Published: 2024
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20. Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial

Author: Martínez-González, Miguel A, Fernandez-Lazaro, Cesar I, Toledo, Estefanía, Díaz-López, Andrés, Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M, Wärnberg, Julia, Martínez, J Alfredo, Serra-Majem, Luís, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Pintó, Xavier, Tur, Josep A, López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Sánchez, Vicente Martín, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Portoles, Olga, Soria-Florido, María, Konieczna, Jadwiga, Navarrete-Muñoz, Eva M, Tojal-Sierra, Lucas, Fernández-García, José C, Abete, Itziar, Henríquez-Sánchez, Patricia, Muñoz-Garach, Araceli, Santos-Lozano, José M, Corbella, Emili, del Mar Bibiloni, Maria, Becerra-Tomás, Nerea, Barragán, Rocío, Castañer, Olga, Fiol, Miquel, de la Hera, Manoli García, Belló-Mora, María C, Gea, Alfredo, Babio, Nancy, Fitó, Montse, Ruiz-Canela, Miguel, Zazpe, Itziar, and Salas-Salvadó, Jordi
Published: 2020
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21. Effect of an Intensive Lifestyle Intervention on Circulating Biomarkers of Atrial Fibrillation-Related Pathways among Adults with Metabolic Syndrome: Results from a Randomized Trial

Author: Medicina, Medikuntza, Li, Linzi, Alonso, Alvaro, Romaguera, Dora, Alonso Gómez, Ángel María, Razquin, Cristina, Tojal Sierra, Lucas, Fiol, Miquel, Martínez González, Miguel Ángel, Subramanya, Vinita, Salas Salvadó, Jordi, Fitó, Montserrat, Toledo, Estefanía, Medicina, Medikuntza, Li, Linzi, Alonso, Alvaro, Romaguera, Dora, Alonso Gómez, Ángel María, Razquin, Cristina, Tojal Sierra, Lucas, Fiol, Miquel, Martínez González, Miguel Ángel, Subramanya, Vinita, Salas Salvadó, Jordi, Fitó, Montserrat, and Toledo, Estefanía
Abstract: Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in the PREDIMED-Plus trial, a Spanish randomized trial conducted in adults (55–75 years) with metabolic syndrome and body mass index between 27–40 kg/m2. Eligible participants were randomized 1:1 to an intensive lifestyle intervention, emphasizing physical activity, weight loss, and adherence to an energy-reduced Mediterranean diet or to a control group. Serum biomarkers [carboxy-terminal propeptide of procollagen type I (PICP), high-sensitivity troponin T (hsTnT), high-sensitivity C reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP)] were measured at baseline, 3 and 5 years after randomization. Mixed models were used to evaluate the effect of intervention on changes in biomarkers through year 5. Mediation analysis was performed to examine the proportion mediated by each component of the intervention. Results: At baseline, participants’ mean age was 65, 40% were female, and 50% were assigned to the intervention. After five years, mean changes in log-transformed biomarkers were −0.01 (PICP), 0.20 (hsTnT), −0.17 (hsCRP), 0.12 (3-NT), and 0.27 (NT-proBNP). Compared to the control group, participants in the intervention group experienced greater decreases in hsCRP (−14%, 95% confidence interval (CI) −26%, 0%) or smaller increases in 3-NT (−16%, 95% CI −25%, −5%) and NT-proBNP (−12%, 95% CI −23%, 1%). The intervention had minimal impact on hsTnT (−3%, 95% CI −7%, 2%) or PICP concentrations (−2%, 95% CI −9%, 6%). The effect of the intervention on hsCRP was primarily mediated by weight loss (89% at year 5). Conclusions: Over five years, a dietary and lifestyle intervention for weight-loss favorably affected concentrat
Published: 2024

22. Effect of an Intensive Lifestyle Intervention on Circulating Biomarkers of Atrial Fibrillation-Related Pathways among Adults with Metabolic Syndrome: Results from a Randomized Trial

Author: Universitat Rovira i Virgili, Li, Linzi; Alonso, Alvaro; Romaguera, Dora; Alonso-Gomez, Angel M; Razquin, Cristina; Tojal-Sierra, Lucas; Fiol, Miquel; Martinez-Gonzalez, Miguel Angel; Subramanya, Vinita; Salas-Salvado, Jordi; Fito, Montserrat; Toledo, Estefania, Universitat Rovira i Virgili, and Li, Linzi; Alonso, Alvaro; Romaguera, Dora; Alonso-Gomez, Angel M; Razquin, Cristina; Tojal-Sierra, Lucas; Fiol, Miquel; Martinez-Gonzalez, Miguel Angel; Subramanya, Vinita; Salas-Salvado, Jordi; Fito, Montserrat; Toledo, Estefania
Abstract: Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in the PREDIMED-Plus trial, a Spanish randomized trial conducted in adults (55-75 years) with metabolic syndrome and body mass index between 27-40 kg/m2. Eligible participants were randomized 1:1 to an intensive lifestyle intervention, emphasizing physical activity, weight loss, and adherence to an energy-reduced Mediterranean diet or to a control group. Serum biomarkers [carboxy-terminal propeptide of procollagen type I (PICP), high-sensitivity troponin T (hsTnT), high-sensitivity C reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP)] were measured at baseline, 3 and 5 years after randomization. Mixed models were used to evaluate the effect of intervention on changes in biomarkers through year 5. Mediation analysis was performed to examine the proportion mediated by each component of the intervention. Results: At baseline, participants' mean age was 65, 40% were female, and 50% were assigned to the intervention. After five years, mean changes in log-transformed biomarkers were -0.01 (PICP), 0.20 (hsTnT), -0.17 (hsCRP), 0.12 (3-NT), and 0.27 (NT-proBNP). Compared to the control group, participants in the intervention group experienced greater decreases in hsCRP (-14%, 95% confidence interval (CI) -26%, 0%) or smaller increases in 3-NT (-16%, 95% CI -25%, -5%) and NT-proBNP (-12%, 95% CI -23%, 1%). The intervention had minimal impact on hsTnT (-3%, 95% CI -7%, 2%) or PICP concentrations (-2%, 95% CI -9%, 6%). The eff
Published: 2024

23. Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk

Author: Universitat Rovira i Virgili, Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; Mas-Llado, Caterina; Li, Linzi; Gonzalez-Casanova, Ines; Salas-Salvado, Jordi; Fito, Montserrat; Alonso, Alvaro, Universitat Rovira i Virgili, and Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; Mas-Llado, Caterina; Li, Linzi; Gonzalez-Casanova, Ines; Salas-Salvado, Jordi; Fito, Montserrat; Alonso, Alvaro
Abstract: Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.Methods and Results We studied 503 participants from the PREDIMED-Plus (Prevencion con Dieta Mediterranea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).Conclusions In a population at high cardiovascular risk, increased alcohol consumption
Published: 2024

24. Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome

Author: Universitat Rovira i Virgili, Rossello, Xavier; Ramallal, Raul; Romaguera, Dora; Alonso-Gomez, Angel M; Alonso, Alvaro; Tojal-Sierra, Lucas; Fernandez-Palomeque, Carlos; Martinez-Gonzalez, Miguel Angel; Garrido-Uriarte, Maria; Lopez, Luis; Diaz, Agnes; Zaldua-Irastorza, Olatz; Shah, Amit J; Salas-Salvado, Jordi; Fito, Montserrat; Toledo, Estefania, Universitat Rovira i Virgili, and Rossello, Xavier; Ramallal, Raul; Romaguera, Dora; Alonso-Gomez, Angel M; Alonso, Alvaro; Tojal-Sierra, Lucas; Fernandez-Palomeque, Carlos; Martinez-Gonzalez, Miguel Angel; Garrido-Uriarte, Maria; Lopez, Luis; Diaz, Agnes; Zaldua-Irastorza, Olatz; Shah, Amit J; Salas-Salvado, Jordi; Fito, Montserrat; Toledo, Estefania
Abstract: Aims To evaluate the effect of an intensive lifestyle intervention (ILI) on the structural and functional cardiac substrate of atrial fibrillation (AF) in overweight or obese people with metabolic syndrome (Mets).Methods and results Participants of the PREvencion con DIeta MEDiterranea-Plus trial (n = 6874) were randomized 1:1 to an ILI programme based on an energy-reduced Mediterranean diet, increased physical activity, and cognitive-behavioural weight management or to a control intervention of low-intensity dietary advice. A core echocardiography lab evaluated left atrial (LA) strain, function, and volumes in 534 participants at baseline, 3-year, and 5-year follow-ups. Mixed models were used to evaluate the effect of the ILI on LA structure and function. In the subsample, the baseline mean age was 65 years [standard deviation (SD) 5 years], and 40% of the participants were women. The mean weight change after 5 years was -3.9 kg (SD 5.3 kg) in the ILI group and -0.3 kg (SD 5.1 kg) in the control group. Over the 5-year period, both groups experienced a worsening of LA structure and function, with increases in LA volumes and stiffness index and decreases in LA longitudinal strain, LA function index, and LA emptying fraction over time. Changes in the ILI and control groups were not significantly different for any of the primary outcomes {LA emptying fraction: -0.95% [95% confidence interval (CI) -0.93, -0.98] in the control group, -0.97% [95% CI -0.94, -1.00] in the ILI group, Pbetween groups = 0.80; LA longitudinal strain: 0.82% [95% CI 0.79, 0.85] in the control group, 0.85% [95% CI 0.82, 0.89] in the ILI group, Pbetween groups = 0.24} or any of the secondary outcomes.Conclusion In overweight or obese people with Mets, an ILI had no impact on the underlying structural a
Published: 2024

25. Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity

Author: Alonso-Gómez, Angel M., Tojal Sierra, Lucas, Fortuny Frau, Elena, Goicolea Güemez, Leire, Aboitiz Uribarri, Ane, Portillo, María P., Toledo, Estefanía, Schröder, Helmut, Salas-Salvadó, Jordi, and Arós Borau, Fernando
Published: 2019
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26. Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome

Author: Rossello, Xavier, primary, Ramallal, Raúl, additional, Romaguera, Dora, additional, Alonso-Gómez, Ángel M, additional, Alonso, Alvaro, additional, Tojal-Sierra, Lucas, additional, Fernández-Palomeque, Carlos, additional, Martínez-González, Miguel Ángel, additional, Garrido-Uriarte, María, additional, López, Luis, additional, Díaz, Agnes, additional, Zaldua-Irastorza, Olatz, additional, Shah, Amit J, additional, Salas-Salvadó, Jordi, additional, Fitó, Montserrat, additional, and Toledo, Estefania, additional
Published: 2023
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27. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Author: Domínguez‐López, Inés, primary, Galkina, Polina, additional, Parilli‐Moser, Isabella, additional, Arancibia‐Riveros, Camila, additional, Martínez‐González, Miguel Ángel, additional, Salas‐Salvadó, Jordi, additional, Corella, Dolores, additional, Malcampo, Mireia, additional, Martínez, J. Alfredo, additional, Tojal‐Sierra, Lucas, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López‐Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos‐Lozano, José Manuel, additional, Serra‐Majem, Lluís, additional, Bueno‐Cavanillas, Aurora, additional, Tur, Josep A., additional, Rubín‐García, María, additional, Pintó, Xavier, additional, Fernández‐Aranda, Fernando, additional, Delgado‐Rodríguez, Miguel, additional, Barabash‐Bustelo, Ana, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Toledo, Estefania, additional, Atzeni, Alessandro, additional, Asensio, Eva M., additional, Vera, Natàlia, additional, Garcia‐Rios, Antonio, additional, Torres‐Collado, Laura, additional, Pérez‐Farinós, Napoleón, additional, Zulet, Marian, additional, Chaplin, Alice, additional, Casas, Rosa, additional, Martín‐Peláez, Sandra, additional, Vaquero‐Luna, Jessica, additional, Gómez‐Pérez, Ana Maria, additional, Vázquez‐Ruiz, Zenaida, additional, Shyam, Sangeetha, additional, Ortega‐Azorín, Carolina, additional, Talens, Natàlia, additional, Peña‐Orihuela, Patricia J., additional, Oncina‐Canovas, Alejandro, additional, Diez‐Espino, Javier, additional, Babio, Nancy, additional, Fitó, Montserrat, additional, and Lamuela‐Raventós, Rosa M., additional
Published: 2023
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28. Association of alcohol consumption with circulating biomarkers of atrial fibrillation-related pathways in a population at high cardiometabolic risk

Author: Alam, Aniqa B., primary, Toledo-Atucha, Estefania, additional, Romaguera, Dora, additional, Alonso-Gómez, Angel M., additional, Martínez-Gonzalez, Miguel A., additional, Tojal-Sierra, Lucas, additional, Razquin, Cristina, additional, Noris Mora, Marta, additional, Li, Linzi, additional, Subramanya, Vinita, additional, Salas-Salvadó, Jordi, additional, Fitó, Montserrat, additional, and Alonso, Alvaro, additional
Published: 2023
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29. Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk

Author: Donat-Vargas, Carolina, primary, Mico, Víctor, additional, San-Cristobal, Rodrigo, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Alonso-Gómez, Ángel Maria, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Damas-Fuentes, Miguel, additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep Antoni, additional, Cinza-Sanjurjo, Sergio, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Causso, Claudia, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Manzanares, Josep Maria, additional, Ortega-Azorín, Carolina, additional, Castañer, Olga, additional, Peña-Orihuela, Patricia Judith, additional, Zazo, Juan Manuel, additional, Muñoz Bravo, Carlos, additional, Martinez-Urbistondo, Diego, additional, Chaplin, Alice, additional, Casas, Rosa, additional, Cano Ibáñez, Naomi, additional, Tojal-Sierra, Lucas, additional, Gómez-Perez, Ana María, additional, Pascual Roquet-Jalmar, Elena, additional, Mestre, Cristina, additional, Barragán, Rocío, additional, Schröder, Helmut, additional, Garcia-Rios, Antonio, additional, Candela García, Inmaculada, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Malcampo, Mireia, additional, Daimiel, Lidia, additional, and Martínez, Alfredo, additional
Published: 2023
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30. Lifestyles, Left Atrial Structure and Function, and Cognitive Decline in Adults with Metabolic Syndrome

Author: Gonzalez Casanova, Ines, primary, Alonso-Gómez, Ángel M., additional, Romaguera, Dora, additional, Toledo, Estefanía, additional, Li, Linzi, additional, Fortuny, Elena, additional, López, Luis, additional, Ramallal, Raúl, additional, Salas-Salvadó, Jordi, additional, Tojal-Sierra, Lucas, additional, Castañer, Olga, additional, and Alonso, Alvaro, additional
Published: 2023
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31. Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome

Author: Shyam, Sangeetha, primary, Gómez-Martínez, Carlos, additional, Paz-Graniel, Indira, additional, Gaforio, José J., additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Ortiz Ramos, María, additional, Vidal, Josep, additional, Mar Alcarria, Maria, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Fernandez-Aranda, Fernando, additional, Nishi, Stephanie K., additional, García Regata, Oscar, additional, Toledo, Estefania, additional, Sorli, Jose V., additional, Castañer, Olga, additional, Garcia-Rios, Antonio, additional, Valls-Enguix, Rafael, additional, Perez-Farinos, Napoleon, additional, Zulet, M. Angeles, additional, Rayó-Gago, Elena, additional, Casas, Rosa, additional, Rivera-Izquierdo, Mario, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Buil-Cosiales, Pilar, additional, Fernández-Carrion, Rebeca, additional, Goday, Albert, additional, Peña-Orihuela, Patricia J., additional, Compañ-Gabucio, Laura, additional, Diez-Espino, Javier, additional, Tello, Susanna, additional, González-Pinto, Ana, additional, de la O, Víctor, additional, Delgado-Rodríguez, Miguel, additional, Babio, Nancy, additional, and Salas-Salvadó, Jordi, additional
Published: 2023
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32. Impact of SARS‐Cov‐2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry

Author: Gimeno, Juan R., Olivotto, Iacopo, Isabel Rodriguez, Ana, Ho, Carolyn Y., Fernandez, Adrian, Quiroga, Alejandro, Angeles Espinosa, Mari, Gomez-Gonzalez, Cristina, Robledo, Maria, Tojal-Sierra, Lucas, Day, Sharlene M., Owens, Anjali, Barriales-Villa, Roberto, Maria Larranaga, Jose, Rodriguez-Palomares, Jose, Gonzalez-del-Hoyo, Maribel, Piqueras-Flores, Jesus, Reza, Nosheen, Chumakova, Olga, Ashley, Euan A., Parikh, Victoria, Wheeler, Matthew, Jacoby, Daniel, Pereira, Alexandre C., Saberi, Sara, Helms, Adam S., Villacorta, Eduardo, Gallego-Delgado, Maria, Castro, Daniel, Dominguez, Fernando, Ripoll-Vera, Tomas, Zorio-Grima, Esther, Carlos Sanchez-Martinez, Jose, Garcia-Alvarez, Ana, Arbelo, Elena, Victoria Mogollon, Maria, Eugenia Fuentes-Canamero, Maria, Grande, Elias, Pena, Carlos, Monserrat, Lorenzo, Lakdawala, Neal K., Dilema Int Cardiomyopathy Heart Fa, [Gimeno, Juan R.] Univ Murcia, Dept Med Interns, Ctra Finca Buenavista S-N,Campus Ciencias Salud, Murcia 30120, Spain, [Isabel Rodriguez, Ana] Univ Murcia, Dept Med Interns, Ctra Finca Buenavista S-N,Campus Ciencias Salud, Murcia 30120, Spain, [Gimeno, Juan R.] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Isabel Rodriguez, Ana] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Castro, Daniel] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Dominguez, Fernando] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Gimeno, Juan R.] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Angeles Espinosa, Mari] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Gomez-Gonzalez, Cristina] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Barriales-Villa, Roberto] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Maria Larranaga, Jose] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Rodriguez-Palomares, Jose] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Gonzalez-del-Hoyo, Maribel] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Villacorta, Eduardo] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Gallego-Delgado, Maria] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Castro, Daniel] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Dominguez, Fernando] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Zorio-Grima, Esther] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Carlos Sanchez-Martinez, Jose] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Garcia-Alvarez, Ana] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Arbelo, Elena] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Olivotto, Iacopo] Careggi Univ Hosp, Cardiomyopathy Unit, Florence, Italy, [Ho, Carolyn Y.] Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA, [Lakdawala, Neal K.] Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA, [Fernandez, Adrian] Favaloro Fdn Univ Hosp, Unidad Cardiopatias Familiares, Buenos Aires, DF, Argentina, [Quiroga, Alejandro] Favaloro Fdn Univ Hosp, Unidad Cardiopatias Familiares, Buenos Aires, DF, Argentina, [Angeles Espinosa, Mari] Hosp Gen Univ Gregorio Maranon, Unidad Cardiopatias Familiares, Madrid, Spain, [Gomez-Gonzalez, Cristina] Hosp Gen Univ Gregorio Maranon, Unidad Cardiopatias Familiares, Madrid, Spain, [Robledo, Maria] Hosp Univ Araba Txagorritxu, Alava, Spain, [Tojal-Sierra, Lucas] Hosp Univ Araba Txagorritxu, Alava, Spain, [Day, Sharlene M.] Hosp Univ Penn, Dept Med, Philadelphia, PA 19104 USA, [Owens, Anjali] Hosp Univ Penn, Dept Med, Philadelphia, PA 19104 USA, [Reza, Nosheen] Hosp Univ Penn, Dept Med, Philadelphia, PA 19104 USA, [Barriales-Villa, Roberto] Complexo Hosp Univ A Coruna, Unidad CSUR Cardiopatias Familiares, La Coruna, Spain, [Maria Larranaga, Jose] Complexo Hosp Univ A Coruna, Unidad CSUR Cardiopatias Familiares, La Coruna, Spain, [Rodriguez-Palomares, Jose] Hosp Univ Vall dHebron, Dept Cardiol, Barcelona, Spain, [Gonzalez-del-Hoyo, Maribel] Hosp Univ Vall dHebron, Dept Cardiol, Barcelona, Spain, [Rodriguez-Palomares, Jose] Univ Autonoma Barcelona, Vall dHebron Inst Recerca VHIR, Barcelona, Spain, [Gonzalez-del-Hoyo, Maribel] Univ Autonoma Barcelona, Vall dHebron Inst Recerca VHIR, Barcelona, Spain, [Piqueras-Flores, Jesus] Hosp Gen Univ Ciudad Real, Cardiac Dept, Ciudad Real, Spain, [Chumakova, Olga] Municipal Clin Hosp 17, Moscow, Russia, [Ashley, Euan A.] Stanford Univ, Med Ctr, Ctr Inherited Heart Dis, Stanford, CA 94305 USA, [Parikh, Victoria] Stanford Univ, Med Ctr, Ctr Inherited Heart Dis, Stanford, CA 94305 USA, [Wheeler, Matthew] Stanford Univ, Med Ctr, Ctr Inherited Heart Dis, Stanford, CA 94305 USA, [Jacoby, Daniel] Yale New Haven Hosp, New Haven, CT USA, [Pereira, Alexandre C.] Univ Sao Paulo, Hosp Clin, Sao Paulo, Brazil, [Saberi, Sara] Univ Michigan Hosp, Dept Internal Med, Ann Arbor, MI 48109 USA, [Helms, Adam S.] Univ Michigan Hosp, Dept Internal Med, Ann Arbor, MI 48109 USA, [Villacorta, Eduardo] Complejo Asistencial Univ Salamanca, Serv Cardiol, Unidad Cardiopatias Familiares, Salamanca, Spain, [Gallego-Delgado, Maria] Complejo Asistencial Univ Salamanca, Serv Cardiol, Unidad Cardiopatias Familiares, Salamanca, Spain, [Villacorta, Eduardo] Inst Invest Biomed Salamanca IBSAL, Gerencia Reg Salud Castilla & Leon SACYL, Salamanca, Spain, [Gallego-Delgado, Maria] Inst Invest Biomed Salamanca IBSAL, Gerencia Reg Salud Castilla & Leon SACYL, Salamanca, Spain, [Villacorta, Eduardo] Univ Salamanca, Dept Med, Salamanca, Spain, [Gallego-Delgado, Maria] Univ Salamanca, Dept Med, Salamanca, Spain, [Castro, Daniel] Hosp Univ Puerta Hierro Majadahonda, Unidad CSUR ERN Cardiopatias Familiares, Madrid, Spain, [Dominguez, Fernando] Hosp Univ Puerta Hierro Majadahonda, Unidad CSUR ERN Cardiopatias Familiares, Madrid, Spain, [Ripoll-Vera, Tomas] Hosp Univ Son Llatzer, Unidad Cardiopatias Familiares, Mallorca, Spain, [Zorio-Grima, Esther] Hosp Univ & Politecn La Fe, Unidad Cardiopatias Familiares, Valencia, Spain, [Carlos Sanchez-Martinez, Jose] Hosp Univ & Politecn La Fe, Unidad Cardiopatias Familiares, Valencia, Spain, [Garcia-Alvarez, Ana] Univ Barcelona, Hosp Clin, Cardiol Dept, Arrhythmia Sect, Barcelona, Spain, [Arbelo, Elena] Univ Barcelona, Hosp Clin, Cardiol Dept, Arrhythmia Sect, Barcelona, Spain, [Garcia-Alvarez, Ana] Inst Invest August Pi & Sunyer IDIBAPS, Barcelona, Spain, [Arbelo, Elena] Inst Invest August Pi & Sunyer IDIBAPS, Barcelona, Spain, [Victoria Mogollon, Maria] Hosp San Pedro Alcantara, Cardiac Dept, Caceres, Spain, [Eugenia Fuentes-Canamero, Maria] Badajoz Univ Hosp, Cardiac Dept, Badajoz, Spain, [Grande, Elias] Dilemma Solut SL, La Coruna, Spain, [Pena, Carlos] Dilemma Solut SL, La Coruna, Spain, [Monserrat, Lorenzo] Dilemma Solut SL, La Coruna, SpainHosp Univ Virgen de la Victoria, Unidad Insuficiencia Cardiaca & Cardiopatias Fami, Serv Cardiol, Malaga, SpainHosp Vega Baja, Cardiac Dept, Alicante, SpainHosp Univ Virgen del Rocio, Unidad Cardiopatias Familiares, Seville, SpainUniv Trieste, Azienda Sanitaria Univ Giuliano Isontina ASUGI, Cardiothoracovasc Dept, Trieste, ItalyHosp Univ Infanta Leonor, Cardiac Dept, Madrid, SpainHosp Gen Univ Alicante, Unidad Cardiopatias Familiares, Alicante, SpainHosp Arquitecto Morcide, Cardiac Dept, Ferrol, Spain, Instituto de Salud Carlos III (ICSIII), MyoKardia/Bristol Myers Squibb, Institut Català de la Salut, [Gimeno JR] Departamento de Medicina Interna, Universidad de Murcia, Murcia, Spain. European Reference Networks for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart), Amsterdam, The Netherlands. Center for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Olivotto I] Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy. [Rodríguez AI] Departamento de Medicina Interna, Universidad de Murcia, Murcia, Spain. European Reference Networks for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart), Amsterdam, The Netherlands. [Ho CY] Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA. [Fernández A, Quiroga A] Unidad de Cardiopatías Familiares, Favaloro Foundation University Hospital, Buenos Aires, Argentina. [Rodríguez-Palomares J, González-del-Hoyo M] Center for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Madrid, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Male, Adult, Registry, Cardiology, Heart failure, Miocardi - Malalties - Factors de risc, técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Ventricular Dysfunction, Left, Atrial Fibrillation, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Humans, Disease, Registries, Aged, COVID-19 (Malaltia) - Complicacions, SARS-CoV-2, SARS-CoV-2 infection, Cor - Hipertròfia, COVID-19, Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Cardiomyopathy, Hypertrophic [DISEASES], Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Middle Aged, Cardiomyopathy, Hypertrophic, Prognosis, Classification, Hypertrophic cardiomyopathy, enfermedades cardiovasculares::enfermedades cardíacas::miocardiopatías::miocardiopatía hipertrófica [ENFERMEDADES], Female, Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Statement, Cardiology and Cardiovascular Medicine
Abstract: COVID-19; SARS-CoV-2 infection; Heart failure COVID-19; Infección por SARS-CoV-2; Insuficiencia cardiaca COVID-19; Infecció per SARS-CoV-2; Insuficiència cardíaca Aims To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. Methods and results Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12–4.51], P = 0.0229}, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75–9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16–26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20–49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98–2.91, P = 0.0600). Conclusions Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality. The project was funded by a grant from the Instituto de Salud Carlos III (ICSIII, COV20 00420). We should state that the SHaRe registry has been supported by an unrestricted grant from MyoKardia/Bristol Myers Squibb.
Published: 2022
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33. Effect of an Intensive Lifestyle Intervention on Circulating Biomarkers of Atrial Fibrillation-Related Pathways among Adults with Metabolic Syndrome: Results from a Randomized Trial.

Author: Li, Linzi, Alonso, Alvaro, Romaguera, Dora, Alonso-Gómez, Angel M., Razquin, Cristina, Tojal-Sierra, Lucas, Fiol, Miquel, Martínez-González, Miguel Angel, Subramanya, Vinita, Salas-Salvadó, Jordi, Fito, Montserrat, and Toledo, Estefanía
Subjects: METABOLIC syndrome, PEPTIDES, ATRIAL fibrillation, MEDITERRANEAN diet, WEIGHT loss
Abstract: Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in the PREDIMED-Plus trial, a Spanish randomized trial conducted in adults (55–75 years) with metabolic syndrome and body mass index between 27–40 kg/m2. Eligible participants were randomized 1:1 to an intensive lifestyle intervention, emphasizing physical activity, weight loss, and adherence to an energy-reduced Mediterranean diet or to a control group. Serum biomarkers [carboxy-terminal propeptide of procollagen type I (PICP), high-sensitivity troponin T (hsTnT), high-sensitivity C reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP)] were measured at baseline, 3 and 5 years after randomization. Mixed models were used to evaluate the effect of intervention on changes in biomarkers through year 5. Mediation analysis was performed to examine the proportion mediated by each component of the intervention. Results: At baseline, participants' mean age was 65, 40% were female, and 50% were assigned to the intervention. After five years, mean changes in log-transformed biomarkers were −0.01 (PICP), 0.20 (hsTnT), −0.17 (hsCRP), 0.12 (3-NT), and 0.27 (NT-proBNP). Compared to the control group, participants in the intervention group experienced greater decreases in hsCRP (−14%, 95% confidence interval (CI) −26%, 0%) or smaller increases in 3-NT (−16%, 95% CI −25%, −5%) and NT-proBNP (−12%, 95% CI −23%, 1%). The intervention had minimal impact on hsTnT (−3%, 95% CI −7%, 2%) or PICP concentrations (−2%, 95% CI −9%, 6%). The effect of the intervention on hsCRP was primarily mediated by weight loss (89% at year 5). Conclusions: Over five years, a dietary and lifestyle intervention for weight-loss favorably affected concentrations of hsCRP, 3-NT, and NT-proBNP, pointing to specific mechanisms in pathways linking lifestyles and AF. [ABSTRACT FROM AUTHOR]
Published: 2024
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34. Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome.

Author: Rossello, Xavier, Ramallal, Raúl, Romaguera, Dora, Alonso-Gómez, Ángel M, Alonso, Alvaro, Tojal-Sierra, Lucas, Fernández-Palomeque, Carlos, Martínez-González, Miguel Ángel, Garrido-Uriarte, María, López, Luis, Díaz, Agnes, Zaldua-Irastorza, Olatz, Shah, Amit J, Salas-Salvadó, Jordi, Fitó, Montserrat, and Toledo, Estefania
Published: 2024
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35. Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome

Author: Rognoni, Teresa, primary, Fernandez-Matarrubia, Marta, additional, Martinez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Castañer, Olga, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Gómez-Gracia, Enrique, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, Lluis, additional, Cano Ibañez, Naomi, additional, Tur, Josep A., additional, Micó Pérez, Rafael, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Ortiz Ramos, María, additional, Vidal Martín, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Goñi-Ruiz, Nuria, additional, Babio, Nancy, additional, Sorlí, José V., additional, Schröder, Helmut, additional, García-Rios, Antonio, additional, Compañ-Gabucio, Laura, additional, Warnberg, Julia, additional, Zulet, M. Ángeles, additional, Chaplin, Alice, additional, Sacanella, Emilio, additional, Bouzalmate-Hajjaj, Amira, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Vázquez, Zenaida, additional, Gómez-Martínez, Carlos, additional, Saiz, Carmen, additional, Malcampo, Mireia, additional, Ortiz-Morales, Ana M., additional, Martínez-Avilés, Vanessa, additional, García-Gavilan, Jesús, additional, Abete, Itziar, additional, Fitó, Montserrat, additional, and Toledo, Estefanía, additional
Published: 2023
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36. Association of monetary diet cost of foods and diet quality in Spanish older adults

Author: Bouzas, Cristina, primary, Pastor, Rosario, additional, García, Silvia, additional, Monserrat-Mesquida, Margalida, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Lopez-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Riquelme-Gallego, Blanca, additional, Romero-Secin, Anny, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía, Pilar, additional, Vidal, Josep, additional, Zapatero, Miriam, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, García-Arellano, Ana, additional, Babio, Nancy, additional, Gonzalez-Monje, Inmaculada, additional, Castañer, Olga, additional, Abete, Itziar, additional, Tojal-Sierra, Lucas, additional, Benavente-Marín, Juan Carlos, additional, Signes-Pastor, Antonio, additional, Konieczna, Jadwiga, additional, García-Ríos, Antonio, additional, Castro-Barquero, Sara, additional, Fernández-García, José C., additional, Santos-Lozano, José Manuel, additional, Bes-Rastrollo, Maira, additional, Mestres, Cristina, additional, Guillem-Saiz, Patricia, additional, Goday, Albert, additional, Goicolea-Güemez, Leire, additional, Puig-Aguiló, Estanislao, additional, Ruiz-Canela, Miguel, additional, Palau-Galindo, Antoni, additional, Fitó, Montse, additional, and Tur, Josep A., additional
Published: 2023
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37. How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?

Author: Paz-Graniel, Indira, primary, Babio, Nancy, additional, Nishi, Stephanie K., additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Sánchez, Vicente Martín, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Calderon-Sanchez, Cristina, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Fernández-Aranda, Fernando, additional, Toledo, Estefania, additional, Valle-Hita, Cristina, additional, Sorli, Jose V., additional, Lassale, Camille, additional, Garcia-Rios, Antonio, additional, Oncina-Canovas, Alejandro, additional, Barón-López, Francisco Javier, additional, Zulet, M. Angeles, additional, Rayó, Elena, additional, Casas, Rosa, additional, Thomas-Carazo, Esther, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Ruiz-Canela, Miguel, additional, De las Heras-Delgado, Sara, additional, Fernandez-Carrión, Rebeca, additional, Castañer, Olga, additional, Peña-Orihuela, Patricia J., additional, Gonzalez-Palacios, Sandra, additional, Buil-Cosiales, Pilar, additional, Goday, Albert, additional, and Salas-Salvadó, Jordi, additional
Published: 2023
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38. Lifestyles, left atrial structure and function, and cognitive decline in adults with the metabolic syndrome

Author: Gonzalez Casanova, Ines, primary, Alonso-Gómez, Ángel M., additional, Romaguera, Dora, additional, Toledo, Estefanía, additional, Li, Linzi, additional, Fortuny, Elena, additional, López, Luis, additional, Ramallal, Raúl, additional, Salas-Salvadó, Jordi, additional, Tojal-Sierra, Lucas, additional, Castañer, Olga, additional, and Alonso, Alvaro, additional
Published: 2023
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39. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health.

Author: Domínguez‐López, Inés, Galkina, Polina, Parilli‐Moser, Isabella, Arancibia‐Riveros, Camila, Martínez‐González, Miguel Ángel, Salas‐Salvadó, Jordi, Corella, Dolores, Malcampo, Mireia, Martínez, J. Alfredo, Tojal‐Sierra, Lucas, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López‐Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos‐Lozano, José Manuel, Serra‐Majem, Lluís, Bueno‐Cavanillas, Aurora, and Tur, Josep A.
Published: 2024
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40. Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways

Author: Li, Linzi, primary, Alonso, Alvaro, additional, Romaguera, Dora, additional, Alonso-Gómez, Angel M., additional, Razquin, Cristina, additional, Tojal-Sierra, Lucas, additional, Fiol, Miquel, additional, Martínez-González, Miguel Angel, additional, Subramanya, Vinita, additional, Salas-Salvadó, Jordi, additional, Fito, Montserrat, additional, and Toledo, Estefanía, additional
Published: 2023
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41. Associations of alcohol consumption with left atrial morphology and function in a population at high cardiovascular risk

Author: Alam, Aniqa B., primary, Toledo-Atucha, Estefania, additional, Romaguera, Dora, additional, Alonso-Gómez, Angel M., additional, Martínez-Gonzalez, Miguel A., additional, Tojal-Sierra, Lucas, additional, Mora, Marta Noris, additional, Mas-Llado, Caterina, additional, Li, Linzi, additional, Gonzalez-Casanova, Ines, additional, Salas-Salvadó, Jordi, additional, Fitó, Montserrat, additional, and Alonso, Alvaro, additional
Published: 2023
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42. Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity

Author: Paz Graniel, Indira, Colomer, Montserrat, Ros Rahola, Emilio, Buil Cosiales, Pilar, Corella Piquer, Dolores, Babio, Nancy, Martínez, J. Alfredo, 1957, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch Riba, Ramon, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó Sala, Xavier, Gaforio, José J., Matía Martín, Pilar, Vidal i Cortada, Josep, Vázquez, Clotilde, Daimiel, Lidia, García Gavilán, Jesús, Toledo Atucha, Estefanía, Nishi, Stephanie K., Sorlí, José V., Castañer, Olga, García Ríos, Antonio, García de la Hera, Manuela, Barón López, Francisco Javier, Ruiz Canela, Miguel, Morey, Marga, Casas Rodríguez, Rosa M., Garrido Aguilar, Eva María, Tojal Sierra, Lucas, Fernández García, José C., Vázquez Ruiz, Zenaida, Fernández Carrión, Rebeca, Goday Arnó, Albert, Peña Orihuela, Patricia J., Compañ Gabucio, Laura, Schröder, Helmut, 1958, Martínez-González, Miguel Ángel, 1957, and Salas Salvadó, Jordi
Subjects: Weight loss, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Mediterraean diet, COVID-19, PREDIMED-Plus, clinical trial, Clinical trial, lockdown, Aprimament, Mediterranean cooking, Clinical trials, Weight-loss, Cuina mediterrània, Lockdown, Assaigs clínics, weight-loss, Food Science
Abstract: Background: The COVID-19 pandemic has affected the implementation of most ongoing clinical trials worldwide including the PREDIMED-Plus study. The PREDIMED-Plus is an ongoing, multicenter, controlled intervention trial, aimed at weight-loss and cardiovascular disease prevention, in which participants were randomized (1:1 ratio) to an intervention group (energyreduced Mediterranean diet, promotion of physical activity, and behavioral support) or to a control group (Mediterranean diet with usual care advice). When the pandemic began, the trial was in the midst of the planned intervention. The objective of this report was to examine the effects of the pandemic on the delivery of the intervention and to describe the strategies established to mitigate the possible adverse effects of the pandemic lockdown on data collection and adiposity. Methods: We assessed the integrity of the PREDIMED-Plus trial during 5 identified periods of the COVID-19 pandemic determined according to restrictions dictated by the Spanish government authorities. A standardized questionnaire was delivered to each of the 23 PREDIMED-Plus recruiting centers to collected data regarding the trial integrity. The effect of the restrictions on intervention components (diet, physical activity) was evaluated with data obtained in the three identified lockdown phases: pre lockdown, lockdown proper, and post lockdown. Results: During the lockdown (March/2020-June/2021), 4,612 participants (48% women, mean age 65y) attended pre-specified yearly follow-up visits to receive lifestyle recommendations and obtain adiposity measures. The overall mean (SD) of the proportions reported by each center showed that 40.4% (25.4) participants had in-person visits, 39.8% (18.2) participants were contacted by telephone and 35% (26.3) by electronic means. Participants’ follow-up and data collection rates increased across lockdown periods (from 10% at onset to 80% at the end). Compared to pre-lockdown, waist circumference increased during (0.75 cm [95% CI: 0.60–0.91]) and after (0.72 cm [95% CI: 0.56–0.89]) lockdown. Body weight did not change during lockdown (0.01 kg [95% CI: –0.10 to 0.13) and decreased after lockdown (-0.17 kg [95% CI: –0.30 to –0.04]). Conclusion: Mitigating strategies to enforce the intervention and patient’s follow-up during lockdown have been successful in preserving the integrity of the trial and ensuring its continuation, with minor effects on adiposity., Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) European Commission PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206, Especial Action Project, European Research Council (ERC) European Commission 340918 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Center for Forestry Research & Experimentation (CIEF) PROMETEO/2017/017 PROMETEO 21/2021, Department of Health of the Generalitat de Catalunya SLT006/17/00246, Spanish Government FPU 17/01925, Fundacion Francisco Soria Melguizo, ICREA under the ICREA Academia programme, Canadian Institutes of Health Research (CIHR), A European Regional Development Fund PI14/01919 PI14/00853 PI14/01374 PI14/00972 PI14/00728 PI14/01471 PI16/00473 PI16/00662 PI16/01873 PI16/01094 PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI17/00855, The European Regional Development Fund PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158
Published: 2023
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43. Abstract P101: Effect of an Intensive Lifestyle Intervention on Biomarkers of Atrial Fibrillation-Related Pathways Among Overweight Adults: The PREDIMED-PLUS Trial

Author: Li, Linzi, primary, Toledo, Estefania A, additional, Romaguera, Dora, additional, Alonso-Gómez, Angel M, additional, Razquin, Cristina, additional, Tojal-Sierra, Lucas, additional, Fiol, Miquel, additional, Martinez-Gonzalez, Miguel A, additional, Salas-Salvado, Jordi, additional, Fito, Montserrat, additional, and Alonso, Alvaro, additional
Published: 2023
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44. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk

Author: Rubín-García, María, Vitelli-Storelli, Facundo, Álvarez-Álvarez, Laura, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Serra-Majem, Luís I, Cano-Ibañez, Naomi, Tur, Josep A, Marcos-Delgado, Alba, Tresserra-Rimbau, Anna, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Vázquez-Ruiz, Zenaida, Babio, Nancy, Barragán, Rocío, Castañer-Niño, Olga, Razquin, Cristina, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, González-Palacios, Sandra, Morey, Marga, García-Rios, Antonio, Castro-Barquero, Sara, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Ruiz-Canela, Miguel, Castro-Salomó, Antoni, Pascual-Castelló, Eva Cristina, Moldon, Verónica, Bullón-Vela, Vanessa, Sorto-Sanchez, Carolina, Cenoz-Osinaga, Juan Carlos, Gutiérrez, Liliana, Mengual, Maira, Lamuela-Raventós, Rosa María, Martín-Sánchez, Vicente, PREDIMED‐Plus Trial Investigators, and European Commission
Subjects: Male, Coumaric Acids, Polyphenols, Hyperuricemia, Uric Acid, Cross-Sectional Studies, Cardiovascular Diseases, Risk Factors, Heart Disease Risk Factors, Hydroxybenzoates, Humans, Female, Cardiology and Cardiovascular Medicine
Abstract: BACKGROUND: Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. METHODS AND RESULTS: This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, −0.27 to −0.06]) and hydroxycinnamic acids (β coefficient, −0.19 [95% CI, −0.3 to −0.09]), alkylmethoxyphenols (β coefficient, −0.2 [95% CI, −0.31 to −0.1]), and methoxyphenols (β coefficient, −0.24 [95% CI, −0.34 to −0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.80 [95% CI, 0.70–0.92]; and PR, 0.79 [95% CI, 0.69–0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02–0.26]) but not with hyperuricemia. CONCLUSIONS: In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research., European Research Council (ERC) European Commission 2013-2018 340918, official funding agency for biomedical research of the Spanish government Instituto de Salud Carlos III, European Commission PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919, Especial Action Project, La Caixa Foundation 2013ACUP00194, Consejo Interinstitucional de Ciencia y Tecnologia (CICYT) AGL2016-75329-R, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2017/017, Generalitat de Catalunya SGR-2019, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, SEMERGEN (Sociedad Espanola de Medicos de Atencion Primaria), European Cooperation in Science and Technology (COST), IDISBA (Instituto de Investigacion Sanitaria Islas Baleares), European Commission CIBEROBN CB06/03 CB12/03, European Commission European Commission Joint Research Centre EAT2BENI-CE_H2020_SFS2016, Spanish Ministry of Science, Innovation and Universities for the Formacion de Profesorado Universitario FPU17/00785, Instituto de Salud Carlos III, through the Fondo de Investigacion para la Salud - European Regional Development Fund PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI16/00473, Instituto de Salud Carlos III European Commission PI14/00853 PI14/01374 PI14/00972 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI19/01560 PI16/00662 PI16/01873 PI16/01094 PI19/01332 PI14/00728 PI14/01471
Published: 2022
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45. Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

Author: Valle-Hita, Cristina, primary, Becerra-Tomás, Nerea, additional, Díaz-López, Andrés, additional, Vázquez-Ruiz, Zenaida, additional, Megías, Isabel, additional, Corella, Dolores, additional, Goday, Albert, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Amengual-Galbarte, Angela, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, García-Arellano, Ana, additional, Barragán, Rocío, additional, Fitó, Montse, additional, Peña-Orihuela, Patricia J., additional, Asencio-Aznar, Alberto, additional, Gómez-Gracia, Enrique, additional, Martinez-Urbistondo, Diego, additional, Morey, Marga, additional, Casas, Rosa, additional, Garrido-Garrido, Eva María, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Goñi, Estibaliz, additional, Ortega-Azorín, Carolina, additional, Castañer, Olga, additional, Garcia-Rios, Antonio, additional, Gisbert-Sellés, Cristina, additional, Sayón-Orea, Carmen, additional, Schröder, Helmut, additional, Salas-Salvadó, Jordi, additional, and Babio, Nancy, additional
Published: 2022
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46. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Author: Marhuenda-Muñoz, María, primary, Domínguez-López, Inés, additional, Langohr, Klaus, additional, Tresserra-Rimbau, Anna, additional, Martínez González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, María Dolores, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Angel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Ll., additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Fernández de la Puente Cervera, María, additional, Barragán, Rocío, additional, Fitó, Montse, additional, Tojal-Sierra, Lucas, additional, Gómez-Gracia, Enrique, additional, Zazo, Juan Manuel, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Gómez-Pérez, Ana M., additional, Santos-Lozano, José Manuel, additional, Vázquez-Ruiz, Zenaida, additional, Atzeni, Alessandro, additional, Asensio, Eva M., additional, Gili-Riu, M. Mar, additional, Bullon, Vanessa, additional, Moreno-Rodriguez, Anai, additional, Lecea, Oscar, additional, Babio, Nancy, additional, Peñas Lopez, Francesca, additional, Gómez Melis, Guadalupe, additional, and Lamuela-Raventós, Rosa M., additional
Published: 2022
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47. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial

Author: Cano-Ibáñez, Naomi, primary, Serra-Majem, Lluis, additional, Martín-Peláez, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Lassale, Camille, additional, Martínez, Jose Alfredo, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Gómez-Pérez, Ana María, additional, Lapetra, José, additional, Fernández-Aranda, Fernando, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A, additional, Cubelos, Naiara, additional, Pintó, Xavier, additional, Gaforio, José Juan, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Calderón, Cristina, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Gea, Alfredo, additional, Babio, Nancy, additional, Gimenez-Alba, Ignacio Manuel, additional, Zomeño-Fajardo, María Dolores, additional, Abete, Itziar, additional, Tojal Sierra, Lucas, additional, Romero-Galisteo, Rita P, additional, García de la Hera, Manoli, additional, Martín-Padillo, Marian, additional, García-Ríos, Antonio, additional, Casas, Rosa M, additional, Fernández-García, JC, additional, Santos-Lozano, José Manuel, additional, Toledo, Estefanía, additional, Becerra-Tomas, Nerea, additional, Sorli, Jose V, additional, Schröder, Helmut, additional, Zulet, María A, additional, Sorto-Sánchez, Carolina, additional, Diez-Espino, Javier, additional, Gómez-Martínez, Carlos, additional, Fitó, Montse, additional, and Sánchez-Villegas, Almudena, additional
Published: 2022
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48. Associations Between the Modified Food Standard Agency Nutrient Profiling System Dietary Index and Cardiovascular Risk Factors in an Elderly Population

Author: Khoury, Nadine, primary, Gómez-Donoso, Clara, additional, Martínez, María Ángeles, additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, León-Acuña, Ana, additional, Tinahones, Francisco J., additional, Santos-Lozano, José M., additional, Serra-Majem, Luís, additional, Massó Guijarro, Paloma, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Bes-Rastrollo, Maira, additional, Barragan, Rocio, additional, Castañer, Olga, additional, Torres-Peña, Jose D., additional, Notario-Barandiaran, Leyre, additional, Muñoz-Bravo, Carlos, additional, Abete, Itziar, additional, Prohens, Lara, additional, Cano-Ibáñez, Naomi, additional, Tojal Sierra, Lucas, additional, Fernández-García, José Carlos, additional, Sayon-Orea, Carmen, additional, Pascual, Maria, additional, Sorli, Jose V., additional, Zomeño, Dolores, additional, Peña-Orihuela, Patricia J., additional, Signes-Pastor, Antonio J., additional, Basterra-Gortari, F. Javier, additional, Schröeder, Helmut, additional, Salas Salvadó, Jordi, additional, and Babio, Nancy, additional
Published: 2022
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49. The Palma Echo Platform: Rationale and Design of an Echocardiography Core Lab

Author: López, Luis, primary, Rossello, Xavier, additional, Romaguera, Dora, additional, Alonso-Gómez, Ángel M., additional, Toledo, Estefanía, additional, Fortuny, Elena, additional, Noris, Marta, additional, Mas-Lladó, Caterina, additional, Fiol, Miquel, additional, Ramallal, Raul, additional, Tojal-Sierra, Lucas, additional, Alonso, Alvaro, additional, and Fernandez-Palomeque, Carlos, additional
Published: 2022
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50. Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Author: Tresserra Rimbau, Anna, Castro Barquero, Sara, Becerra Tomás, Nerea, Babio, Nancy, Martínez González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel M., Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, Cano Ibáñez, Naomi, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Francisco Javier, Fernández de la Puente, María, Asensio, Eva María, Castañer, Olga, Bullón Vela, Vanessa, Tojal Sierra, Lucas, Gómez Gracia, Enrique, Cases Pérez, Eugenio, Konieczna, Jadwiga, García Ríos, Antonio, Casañas Quintana, Tamara, Bernal López, María Rosa, Santos Lozano, José Manuel, Esteve Luque, Virginia, Bouzas, Cristina, Vázquez Ruiz, Zenaida, Palau Galindo, Antoni, Barragan, Rocio, López Grau, Mercè, Razquín, Cristina, Goicolea Güemez, Leire, Toledo, Estefanía, Vergaz, Manel Vila, Lamuela Raventós, Rosa María, Salas Salvadó, Jordi, Tresserra Rimbau, Anna, Castro Barquero, Sara, Becerra Tomás, Nerea, Babio, Nancy, Martínez González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel M., Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, Cano Ibáñez, Naomi, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Francisco Javier, Fernández de la Puente, María, Asensio, Eva María, Castañer, Olga, Bullón Vela, Vanessa, Tojal Sierra, Lucas, Gómez Gracia, Enrique, Cases Pérez, Eugenio, Konieczna, Jadwiga, García Ríos, Antonio, Casañas Quintana, Tamara, Bernal López, María Rosa, Santos Lozano, José Manuel, Esteve Luque, Virginia, Bouzas, Cristina, Vázquez Ruiz, Zenaida, Palau Galindo, Antoni, Barragan, Rocio, López Grau, Mercè, Razquín, Cristina, Goicolea Güemez, Leire, Toledo, Estefanía, Vergaz, Manel Vila, Lamuela Raventós, Rosa María, and Salas Salvadó, Jordi
Abstract: The PREDIMED-Plus trial was supported by the Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V. (Josep Vidal), including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158)), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil for the PTREDIMED-Plus study, and, Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D., Unión Europea, Consejo Europeo de Investigación, Ministerio de Ciencia y Innovación (España), Ministerio de Economía e Industria (España), Junta de Andalucía. Consejería de Salud, Generalitat Valenciana, Gobierno de Islas Baleares, Instituto de Salud Carlos III, Recercaixa, ICREA, PREDIMED-Plus, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Depto. de Medicina, Fac. de Medicina, TRUE, pub
Published: 2022

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