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Objectives This study aimed to evaluate the effect of labiopalatal inclination of maxillary right central incisor on palatal bone width using cone-beam computed tomography (CBCT). Methods The angle formed between the longitudinal axis of the right central incisor and the palatal plane was measured on 75 CBCT images, and classified into three groups of labially-inclined, lingually-inclined, and normal groups. The total palatal bone thickness in the apical region of the upper right central incisor was linearly measured perpendicular to the tooth axis on sagittal slices. The intraclass correlation coefficient, Kolmogorov-Smirnov test, one-way ANOVA, and Pearson’s and Spearman’s correlation coefficients were used for data analysis (alpha=0.05). Results A significant difference was noted among the groups in the total apical palatal bone thickness (P<0.05). The labially inclined group had significantly lower bone thickness than the other two groups (P=0.002, 95% CI: 5.5-7.38); however, this correlation was inverse (Pearson’s R=-0.58), which means that as the angle between the upper central incisor axis and the palatal plane increased, the bone thickness significantly decreased. No correlation was found between the palatal bone thickness (cancellous or cortical) and tooth inclination (P>0.05). Arch length was not correlated with any group either (P>0.05). Conclusion Labial inclination of upper central incisor causes the root apex to be closer to the palatal alveolar bone, resulting in less apical bone support in the palatal area. [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to compare the efficacy of calcium hydroxide (CH)/saline and CH/ Artemisia persica ( A. persica ) essential oil as an intracanal medicament for radiographic resolution of periapical (PA) lesions in necrotic teeth., Materials and Methods: This randomized clinical trial was conducted on 22 patients with necrotic teeth and PA lesions presenting to two private endodontic offices. The patients were randomly divided into two groups ( n  = 11) to receive CH/saline (control group) and CH/ A. persica essential oil (10%) (intervention group) as intracanal medicaments between treatment sessions. The size of PA radiolucency was measured on parallel PA radiographs taken before treatment and also at 1 and 3 months after completion of treatment. The mean time of healing of PA lesions was also compared between the two groups. Data were analyzed by the independent t -test, chi-square test, and Fisher's exact test (alpha = 0.05)., Results: No significant difference was found between the two groups regarding the changes in the size of PA lesions, relative healing percentage, and speed of healing, neither at 1 nor at 3 months postoperatively ( P > 0.05). Regarding the presence/absence of clinical symptoms in the second treatment session, the intervention group showed greater resolution of symptoms, although the difference did not reach statistical significance ( P > 0.05)., Conclusion: According to the present results, it appears that the addition of A. persica essential oil to CH for application as intracanal medicament does not add any particular advantage., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Ameneh Shareghi et al.)

Background: Non-Syndromic Cleft Lip with or without cleft Palate (NSCL/P) is a common developmental disorder of the head and neck with a multifactorial etiology. The current study aimed to evaluate the potential association of PTCH1 (rs10512248) and RAD54B (rs12681366) polymorphisms with NSCL/P in the Northeast Iranian population., Methods: In the present study, blood samples were taken from 122 subjects with NSCL/P and 161 healthy controls. Polymerase Chain Reaction (PCR) followed by Restriction Fragment Length Polymorphism (RFLP) were used to conduct genotyping of single-nucleotide polymorphisms., Results: Although differences were observed between cases and controls in rs10512248 and rs12681366, our data did not support a significant association of these polymorphisms with NSCL/P in our population., Conclusion: Our findings suggest that polymorphisms of rs10512248 and rs12681366 may not be potential risk factors for NSCL/P in the Northeast Iranian population due to the multifactorial and multiethnicity characteristics of some genes., (Copyright© 2022 Avicenna Research Institute.)