Search

Background and Purpose: The Acceptance and Action Diabetes Questionnaire (AADQ) is a tool for assessing the acceptance of thoughts and emotions related to diabetes in people living with the disease. This study aimed to examine the psychometric properties of the Swedish version of AADQ (Swe-AADQ) in a sample of adults with type 1 diabetes. Methods: To examine the psychometric properties of the Swe-AADQ, the Rasch model was used. Data for 120 individuals were included. Results: The Swe-AADQ showed an acceptable fit to the Rasch model. A sufficiently high value of the separation index indicated a capacity to distinguish between different levels of acceptance in the sample. The 7-point Likert scale was reduced to three categories suggesting an improvement in the ordering of the item thresholds. Conclusions: The Swe-AADQ possesses reasonable quality in terms of reliability and validity. However, there are some deficiencies regarding the categorization of the response rating that should be addressed. [ABSTRACT FROM AUTHOR]

To study the local tissue lactate production in the normal state and its possible disturbances in insulin resistance, rates of lactate release from adipose tissue (AT) and skeletal muscle (SM) were compared postabsorptively and during a hyperinsulinemic euglycemic clamp in 11 healthy nonobese and 11 insulin-resistant obese women. A combination of microdialysis, to measure interstitial lactate, and the 133Xe clearance technique, to determine local blood flow, were used. In the controls, local blood flow increased by 40% in SM (P < 0.05) and remained unchanged in AT, whereas the interstitial-plasma difference in lactate doubled in AT (P < 0.005) and was unaffected in SM during hyperinsulinemia. In the obese, blood flow and interstitial-plasma difference in lactate remained unchanged in both tissues during hyperinsulinemia. The lactate release ([micro]mol*100 [g.sup.-l]*[min.sup.-1]) was 1.17 [+ or -] 0.22 in SM and 0.43 [+ or -] 0.11 in AT among the controls (P < 0.01) and 0.86 [+ or -] 0.23 in SM and 0.83 [+ or -] 0.25 in AT among the obese women in the postabsorptive state. During insulin infusion, lactate release in the controls increased to 1.92 [+ or -] 0.26 in SM (P < 0.005) and to 1.14 [+ or -] 0.22 in AT (P < 0.005) but remained unchanged in the obese women. It is concluded that AT and SM are both significant sources of lactate release postabsorptively, and AT is at least as responsive to insulin as SM. The ability to increase lactate release in response to insulin is impaired in AT and SM in insulin-resistant obese women, involving defective insulin regulation of both tissue lactate metabolism and local blood flow. microdialysis; blood flow

To investigate the antilipolytic effect of insulin in skeletal muscle and adipose tissue in vivo, the rates of glycerol release from the two tissues were compared in 10 nonobese women during a two-step euglycemic hyper-insulinemic clamp, Tissue interstitial glycerol levels were determined by microdialysis, and tissue blood flow was assessed with the [sup.133]Xe clearance technique. Absolute rates of glycerol release were estimated according to Fick's principle. In both adipose tissue and muscle, glycerol levels decreased significantly already during the low insulin infusion rate. The fractional release of glycerol (difference between interstitial glycerol and arterialized venous plasma glycerol) was reduced by more than one-half in adipose tissue (P < 0.0001) in response to insulin, whereas it remained unaltered in skeletal muscle. Muscle blood flow rates increased by 60% (P < 0.02) during insulin infusion; in adipose tissue, blood flow rates did not change significantly in response to insulin. The basal rate of glycerol release from skeletal muscle amounted to ~15% of that from adipose tissue. After insulin infusion, the rate of adipose tissue glycerol release was markedly suppressed, whereas in skeletal muscle the rate of glycerol mobilization did not change significantly in response to insulin. It is concluded that insulin does not inhibit the rate of lipolysis in skeletal muscle of nonobese women. glycerol; microdialysis; blood flow

Research was conducted to characterize the beta-adrenoceptor subtypes that are involved in the in vivo regulation of lipolysis in muscle using the microdialysis method. Results indicate that the beta-2- adrenoceptor is the major adrenoceptor subtype that is vital for the regulation of blood flow in human skeletal muscle. Thus, some involvement of other beta-adrenoceptor subtypes in the regulation of muscle blood flow cannot be excluded.

Research was conducted to investigate concentrations of glycerol and lactate with microdialysis of adipose tissue and skeletal muscle at rest and during conditions that alter lipid and carbohydrate metabolism. Enzymatic fluorometric methods were utilized to measure dialysate glycerole and lactate concentrations. Results indicated that insulin inhibits lipid mobilization and activates lactate production in adipose tissue and skeletal muscle.

Aim: To assess treatment satisfaction and perceived discomfort or pain from the treatment, and potential associations with glycaemic control, type of treatment, perceived burden of diabetes, sex and age, in adolescents with type 1 diabetes.Methods: A cross-sectional study was performed at one paediatric and at one adult diabetes clinic in Sweden, preceded by a translation of 'Diabetes Treatment Satisfaction Questionnaire (DTSQ) Teen'. Adolescents with type 1 diabetes (15-20 years) participated. The questionnaires 'DTSQ Teen' and 'Check your health' were used. Data on glycosylated haemoglobin (HbA1c), type of treatment, sex and age were collected.Results: One hundred and thirty-eight adolescents (70 females, mean age 17.3, mean HbA1c 64.0 mmol/mol) participated. Treatment satisfaction correlated inversely with HbA1c (r = -.352, P < .001) and with all types of burden of diabetes (r = -.342 to -0.467, P < .001), but did not differ with type of treatment, sex and age. Perceived pain correlated inversely with burden on physical health (r = -.265, P = .002), mental health (r = -.237, P = .006) and quality of life (r = -.246, P = .004) but not with HbA1c, age or burden on social relations. Females perceived more discomfort or pain.Conclusion: In Swedish adolescents with type 1 diabetes, treatment satisfaction correlated with both glycaemic control and perceived burden of diabetes. [ABSTRACT FROM AUTHOR]

Focuses on a study which characterized the beta-adrenoceptor subtypes involve in the in vivo regulation of lipolysis in muscle by use of the microdialysis technique. Materials and methods; Insulin and catecholamine concentrations in arterialized blood from a dorsal hand vein during a hypoglycemic clamp; Selective beta-adrenoceptor stimulation in situ.