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2. Campi

Author

Leonesi, S., Toffalori, C., Leonesi, S., and Toffalori, C.

Published
2006
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18. Quantitative polymerase chain reaction-based chimerism in bone marrow or peripheral blood to predict acute myeloid leukemia relapse in high-risk patients: Results from the KIM-PB prospective study

Author

Gambacorta, V, Parolini, R, Xue, E, Greco, R, Bouwmans, E, Toffalori, C, Giglio, F, Assanelli, A, Stanghellini, M, Ambrosi, A, Mazzi, B, Mulder, W, Corti, C, Peccatori, J, Ciceri, F, Vago, L, Gambacorta V., Parolini R., Xue E., Greco R., Bouwmans E. E., Toffalori C., Giglio F., Assanelli A., Stanghellini M. T. L., Ambrosi A., Mazzi B., Mulder W., Corti C., Peccatori J., Ciceri F., Vago L., Gambacorta, V, Parolini, R, Xue, E, Greco, R, Bouwmans, E, Toffalori, C, Giglio, F, Assanelli, A, Stanghellini, M, Ambrosi, A, Mazzi, B, Mulder, W, Corti, C, Peccatori, J, Ciceri, F, Vago, L, Gambacorta V., Parolini R., Xue E., Greco R., Bouwmans E. E., Toffalori C., Giglio F., Assanelli A., Stanghellini M. T. L., Ambrosi A., Mazzi B., Mulder W., Corti C., Peccatori J., Ciceri F., and Vago L.

Published
2021

19. Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation

Author

Crucitti, L, Crocchiolo, R, Toffalori, C, Mazzi, B, Greco, R, Signori, A, Sizzano, F, Chiesa, L, Zino, E, Lupo Stanghellini, M T, Assanelli, A, Carrabba, M G, Marktel, S, Marcatti, M, Bordignon, C, Corti, C, Bernardi, M, Peccatori, J, Bonini, C, Fleischhauer, K, Ciceri, F, and Vago, L

Published
2015
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20. Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Author

Noviello, M, Manfredi, F, Ruggiero, E, Perini, T, Oliveira, G, Cortesi, F, De Simone, P, Toffalori, C, Gambacorta, V, Greco, R, Peccatori, J, Casucci, M, Casorati, G, Dellabona, P, Onozawa, M, Teshima, T, Griffioen, M, Halkes, C, Falkenburg, J, Stolzel, F, Altmann, H, Bornhauser, M, Waterhouse, M, Zeiser, R, Finke, J, Cieri, N, Bondanza, A, Vago, L, Ciceri, F, Bonini, C, Noviello M., Manfredi F., Ruggiero E., Perini T., Oliveira G., Cortesi F., De Simone P., Toffalori C., Gambacorta V., Greco R., Peccatori J., Casucci M., Casorati G., Dellabona P., Onozawa M., Teshima T., Griffioen M., Halkes C. J. M., Falkenburg J. H. F., Stolzel F., Altmann H., Bornhauser M., Waterhouse M., Zeiser R., Finke J., Cieri N., Bondanza A., Vago L., Ciceri F., Bonini C., Noviello, M, Manfredi, F, Ruggiero, E, Perini, T, Oliveira, G, Cortesi, F, De Simone, P, Toffalori, C, Gambacorta, V, Greco, R, Peccatori, J, Casucci, M, Casorati, G, Dellabona, P, Onozawa, M, Teshima, T, Griffioen, M, Halkes, C, Falkenburg, J, Stolzel, F, Altmann, H, Bornhauser, M, Waterhouse, M, Zeiser, R, Finke, J, Cieri, N, Bondanza, A, Vago, L, Ciceri, F, Bonini, C, Noviello M., Manfredi F., Ruggiero E., Perini T., Oliveira G., Cortesi F., De Simone P., Toffalori C., Gambacorta V., Greco R., Peccatori J., Casucci M., Casorati G., Dellabona P., Onozawa M., Teshima T., Griffioen M., Halkes C. J. M., Falkenburg J. H. F., Stolzel F., Altmann H., Bornhauser M., Waterhouse M., Zeiser R., Finke J., Cieri N., Bondanza A., Vago L., Ciceri F., and Bonini C.

Abstract

The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of Inhibitory Receptors (IR; PD-1/CTLA-4/TIM-3/LAG-3/2B4/KLRG1/GITR) on T cells infiltrating the bone marrow (BM) of 32 AML patients relapsing (median 251 days) or maintaining complete remission (CR; median 1 year) after HSCT. A higher proportion of early-differentiated Memory Stem (T SCM ) and Central Memory BM-T cells express multiple IR in relapsing patients than in CR patients. Exhausted BM-T cells at relapse display a restricted TCR repertoire, impaired effector functions and leukemia-reactive specificities. In 57 patients, early detection of severely exhausted (PD-1 + Eomes + T-bet − ) BM-T SCM predicts relapse. Accordingly, leukemia-specific T cells in patients prone to relapse display exhaustion markers, absent in patients maintaining long-term CR. These results highlight a wide, though reversible, immunological dysfunction in the BM of AML patients relapsing after HSCT and suggest new therapeutic opportunities for the disease.

Published
2019

28. PROFILING THE MUTATIONAL LANDSCAPE OF ACUTE MYELOID LEUKEMIA AT RELAPSE AFTER CHEMOTHERAPY AND ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

Author

Sala E, Biavasco F, Bucci G, Toffalori C, Zanotti L, Biancolini D, Antonini E, Carrabba MG, Gentner B, Tresoldi C, Bernardi M, Lazarevic D, Tonon G, Ciceri F, Vago L, Sala, E, Biavasco, F, Bucci, G, Toffalori, C, Zanotti, L, Biancolini, D, Antonini, E, Carrabba, Mg, Gentner, B, Tresoldi, C, Bernardi, M, Lazarevic, D, Tonon, G, Ciceri, F, and Vago, L

Published
2017

30. Post-Transplant Cyclophosphamide Eliminates Mature Donor NK Cells Infused with the Graft, Dampening NK Cell Alloreactivity after Haploidentical HSCT

Author

Russo A, Oliveira G, Greco R, Gambacorta V, Cieri N, Toffalori C, Zito L, Piemontese S, Morelli M, Giglio F, Assanelli A, Stanghellini MTL, Bonini C, Peccatori J, Ciceri F, Vago L, Russo, A, Oliveira, G, Greco, R, Gambacorta, V, Cieri, N, Toffalori, C, Zito, L, Piemontese, S, Morelli, M, Giglio, F, Assanelli, A, Stanghellini, Mtl, Bonini, C, Peccatori, J, Ciceri, F, and Vago, L

Published
2016

31. POST-TRANSPLANT CYCLOPHOSPHAMIDE ELIMINATES MATURE DONOR NK CELLS, DAMPENING NATURAL KILLER CELL ALLOREACTIVITY AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION

Author

Russo A, Oliveira G, Greco R, Gambacorta V, Cieri N, Toffalori C, Zito L, Piemontese S, Morelli M, Giglio F, Assanelli A, Stanghellini MTL, Bonini C, Peccatori J, Ciceri F, Vago L, Russo, A, Oliveira, G, Greco, R, Gambacorta, V, Cieri, N, Toffalori, C, Zito, L, Piemontese, S, Morelli, M, Giglio, F, Assanelli, A, Stanghellini, Mtl, Bonini, C, Peccatori, J, Ciceri, F, and Vago, L

Published
2016

32. NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: Dynamics and clinical implications

Author

Russo, A, Oliveira, G, Berglund, S, Greco, R, Gambacorta, V, Cieri, N, Toffalori, C, Zito, L, Lorentino, F, Piemontese, S, Morelli, M, Giglio, F, Assanelli, A, Stanghellini, M, Bonini, C, Peccatori, J, Ciceri, F, Luznik, L, Vago, L, Russo, Antonio, Oliveira, Giacomo, Berglund, Sofia, Greco, Raffaella, GAMBACORTA, VALENTINA, Cieri, Nicoletta, Toffalori, Cristina, Zito, Laura, Lorentino, Francesca, Piemontese, Simona, Morelli, Mara, Giglio, Fabio, Assanelli, Andrea, Stanghellini, Maria Teresa Lupo, Bonini, Chiara, Peccatori, Jacopo, Ciceri, Fabio, Luznik, Leo, Vago, Luca, Russo, A, Oliveira, G, Berglund, S, Greco, R, Gambacorta, V, Cieri, N, Toffalori, C, Zito, L, Lorentino, F, Piemontese, S, Morelli, M, Giglio, F, Assanelli, A, Stanghellini, M, Bonini, C, Peccatori, J, Ciceri, F, Luznik, L, Vago, L, Russo, Antonio, Oliveira, Giacomo, Berglund, Sofia, Greco, Raffaella, GAMBACORTA, VALENTINA, Cieri, Nicoletta, Toffalori, Cristina, Zito, Laura, Lorentino, Francesca, Piemontese, Simona, Morelli, Mara, Giglio, Fabio, Assanelli, Andrea, Stanghellini, Maria Teresa Lupo, Bonini, Chiara, Peccatori, Jacopo, Ciceri, Fabio, Luznik, Leo, and Vago, Luca

Abstract

The use of posttransplant cyclophosphamide (PT-Cy) as graft-versus-host disease (GVHD) prophylaxis has revolutionized haploidentical hematopoietic stem cell transplantation (HSCT), allowing safe infusion of unmanipulated T cell-replete grafts. PT-Cy selectively eliminates proliferating alloreactive T cells, but whether and how it affects natural killer (NK) cells and their alloreactivity is largely unknown. Here we characterized NK cell dynamics in 17 patients who received unmanipulated haploidentical grafts, containing high numbers of mature NK cells, according to PT-Cy-based protocols in 2 independent centers. In both series, we documented robust proliferation of donor-derived NK cells immediately after HSCT. After infusion of Cy, a marked reduction of proliferating NK cells was evident, suggesting selective purging of dividing cells. Supporting this hypothesis, proliferating NK cells did not express aldehyde dehydrogenase and were killed by Cy in vitro. After ablation of mature NK cells, starting from day 15 after HSCT and favored by the high levels of interleukin-15 present in patients' sera, immature NK cells (CD62L+NKG2A+KIR-) became highly prevalent, possibly directly stemming from infused hematopoietic stem cells. Importantly, also putatively alloreactive single KIR1 NK cells were eliminated by PT-Cy and were thus decreased in numbers and antileukemic potential at day 30 after HSCT. As a consequence, in an extended series of 99 haplo-HSCT with PT-Cy, we found no significant difference in progression-free survival between patients with or without predicted NK alloreactivity (42% vs 52% at 1 year, P = NS). Our data suggest that the majority of mature NK cells infused with unmanipulated grafts are lost upon PT-Cy administration, blunting NK cell alloreactivity in this transplantation setting

Published
2018

33. DROPLET DIGITAL PCR FOR DNMT3A AND IDH1/2 MUTATIONS TO IMPROVE EARLY DETECTION OF ACUTE MYELOID LEUKEMIA RELAPSE AFTER ALLOGENEIC HSCT

Author

Brambati C, Galbiati S, Xue E, Toffalori C, Crucitti L, Greco R, Crippa A, Chiesa L, Soriani N, Mazzi B, Tresoldi C, Peccatori J, Carrabba MG, Bernardi M, Ferrari M, Lampasona V, Ciceri F, Vago L, Brambati, C, Xue, E, Toffalori, C, Galbiati, S, Crucitti, L, Greco, R, Crippa, A, Chiesa, L, Soriani, N, Mazzi, B, Tresoldi, C, Peccatori, J, Carrabba, Mg, Bernardi, M, Ferrari, M, Lampasona, V, Ciceri, F, and Vago, L

Published
2015

34. LEUKEMIA RELAPSE AFTER ALLOGENENIC HSCT DISPLAYS A DISTINCTIVE IMMUNE-RELATED SIGNATURE, WITH FUNCTIONALLY RELEVANT ALTERATIONS IN HLA CLASS II ANTIGEN PRESENTATION AND T CELL COSTIMULATION

Author

Toffalori C, Riba M, Zito L, Oliveira G, Bucci G, Barcella M, Spinelli O, Crucitti L, Cieri N, Cittaro D, Lazarevic D, Peccatori J, Bernardi M, Bonini C, Rambaldi A, Barlassina C, Stupka E, Bianchi M, Ciceri F, Fleischhauer K, Vago L, Toffalori, C, Riba, M, Zito, L, Oliveira, G, Bucci, G, Barcella, M, Spinelli, O, Crucitti, L, Cieri, N, Cittaro, D, Lazarevic, D, Peccatori, J, Bernardi, M, Bonini, C, Rambaldi, A, Barlassina, C, Stupka, E, Bianchi, M, Ciceri, F, Fleischhauer, K, and Vago, L

Published
2015

35. AN INNOVATIVE HUMANIZED MOUSE MODEL TO INVESTIGATE THE INTERPLAY BETWEEN IMMUNE SYSTEM AND ACUTE MYELOID LEUKEMIA IN ALLOGENEIC HSCT

Author

Oliveira G, Casera C, Bucci G, Toffalori C, Garcia-Manteiga JM, Camisa B, Lazarevic D, Crucitti L, Zito L, Carrabba M, Bernardi M, Bianchi M, Bondanza A, Ciceri F, Bonini C, Vago L, Oliveira, G, Casera, C, Bucci, G, Toffalori, C, Garcia-Manteiga, Jm, Camisa, B, Lazarevic, D, Crucitti, L, Zito, L, Carrabba, M, Bernardi, M, Bianchi, M, Bondanza, A, Ciceri, F, Bonini, C, and Vago, L

Published
2015

37. LEUKEMIA RELAPSES AFTER ALLOGENENIC HSCT DISPLAY A DISTINCTIVE IMMUNE-RELATED SIGNATURE, WITH FUNCTIONALLY RELEVANT ALTERATIONS IN HLA CLASS II ANTIGEN PRESENTATION AND T CELL COSTIMULATION

Author

Toffalori, C., Riba, M., Zito, L., Oliveira, G., Bucci, G., Barcella, M., Spinelli, O., Crucitti, L., Cieri, N., Cittaro, D., Lazarevic, D., Peccatori, J., Bernardi, M., Bonini, C., Rambaldi, A., Barlassina, C., Stupka, E., Bianchi, M., Ciceri, F., Fleischhauer, Katharina, Vago, L., Toffalori, C, Riba, M, Zito, L, Oliveira, G, Bucci, G, Barcella, M, Spinelli, O, Crucitti, L, Cieri, N, Cittaro, D, Lazarevic, D, Peccatori, J, Bernardi, M, Bonini, C, Rambaldi, A, Barlassina, C, Stupka, E, Bianchi, M, Ciceri, F, Fleischhauer, K, and Vago, L

Subjects
Medizin
Published
2015

38. CIITA-DEPENDENT TRANSCRIPTIONAL DOWNREGULATION OF HLA CLASS II RESULTS IN LEUKEMIA IMMUNE ESCAPE AND RELAPSE AFTER ALLOGENEIC HSCT

Author

Toffalori, C., Riba, M., Zito, L., Barcella, M., Spinelli, O., Crucitti, L., Peccatori, J., Bernardi, M., Bonini, C., Cittaro, D., Lazarevic, D., Rambaldi, A., Barlassina, C., Stupka, E., Ciceri, F., Fleischhauer, Katharina, Vago, L., Toffalori, C, Riba, M, Zito, L, Barcella, M, Spinelli, O, Crucitti, L, Peccatori, J, Bernardi, M, Bonini, C, Cittaro, D, Lazarevic, D, Rambaldi, A, Barlassina, C, Stupka, E, Ciceri, F, Fleischhauer, K, and Vago, L

Subjects
Medizin, ComputingMethodologies_GENERAL
Abstract

Poster Abstract

Published
2014

39. Droplet Digital PCR for DNMT3A and IDH1/2 Mutations to Improve Early Diagnosis of Acute Myeloid Leukemia Relapse after Allogeneic HSCT

Author

Brambati C, Toffalori C, Xue E, Crucitti L, Greco R, Crippa A, Mazzi B, Tresoldi C, Galbiati S, Bonini C, Peccatori J, Carrabba MG, Bernardi M, Ferrari M, Lampasona V, Ciceri F, Vago L, Brambati, C, Toffalori, C, Xue, E, Crucitti, L, Greco, R, Crippa, A, Mazzi, B, Tresoldi, C, Galbiati, S, Bonini, C, Peccatori, J, Carrabba, Mg, Bernardi, M, Ferrari, M, Lampasona, V, Ciceri, F, and Vago, L

Published
2014

40. ENHANCED ALLOREACTIVITY TO BI-DIRECTIONAL NON-PERMISSIVE HLA-DPB1 MISMATCHES SUPPORTS NON-HIERARCHICAL T-CELL EPITOPE GROUP DIVERSITY AS UNDERLYING BIOLOGICAL MECHANISM

Author

Zito, L., Sizzano, F., Crivello, P., Toffalori, C., Zino, E., Vago, L., Crocchiolo, R., Sacchi, N., Rambaldi, A., Ciceri, F., Claas, F.H.J., Oudshoorn, M., Fleischhauer, K., Zito, L, Sizzano, F, Crivello, P, Toffalori, C, Zino, E, Vago, L, Crocchiolo, R, Sacchi, N, Rambaldi, A, Ciceri, F, Claas, Fhj, Oudshoorn, M, and Fleischhauer, K

Published
2013

41. Incidence, Risk Factors and Clinical Outcome Of Leukemia Relapses Due To Loss Of The Mismatched HLA Haplotype After Partially-Incompatible Hematopoietic Stem Cell Transplantation

Author

Crucitti L, Crocchiolo R, Toffalori C, Stanghellini MTL, Assanelli A, Carrabba M, Mazzi B, Zino E, Marktel S, Marcatti M, Corti C, Bernardi M, Peccatori J, Bordignon C, Bonini C, Fleischhauer K, Ciceri F, Vago L, Crucitti, L, Crocchiolo, R, Toffalori, C, Stanghellini, Mtl, Assanelli, A, Carrabba, M, Mazzi, B, Zino, E, Marktel, S, Marcatti, M, Corti, C, Bernardi, M, Peccatori, J, Bordignon, C, Bonini, C, Fleischhauer, K, Ciceri, F, and Vago, L

Published
2013

42. Loss of mismatched HLA at leukaemia relapse after haematopoietic stem cell transplantation is significantly associated with clinical and immunogenetic hallmarks of donor-versus-host alloreactivity

Author

Crucitti L, Crocchiolo R, Toffalori C, Stanghellini MTL, Assanelli A, Carrabba M, Mazzi B, Zino E, Marktel S, Marcatti M, Corti C, Bernardi M, Peccatori J, Bordignon C, Bonini C, Fleischhauer K, Ciceri F, Vago L, Crucitti, L, Crocchiolo, R, Toffalori, C, Stanghellini, Mtl, Assanelli, A, Carrabba, M, Mazzi, B, Zino, E, Marktel, S, Marcatti, M, Corti, C, Bernardi, M, Peccatori, J, Bordignon, C, Bonini, C, Fleischhauer, K, Ciceri, F, and Vago, L

Published
2013

43. High-Sensitivity Hematopoietic Chimerism By qPCR For Relapse Prediction and Specific Identification Of HLA Loss Leukemic Variants

Author

Vago L, Mazzi B, Chiesa L, Greco R, Pultrone C, Toffoletti E, Toffalori C, Crivello P, Tettamanzi V, Crucitti L, Stanghellini MTL, Assanelli A, Corti C, Bernardi M, Peccatori J, Bonini C, Bost DA, Ciceri F, Fleischhauer K, Vago, L, Mazzi, B, Chiesa, L, Greco, R, Pultrone, C, Toffoletti, E, Toffalori, C, Crivello, P, Tettamanzi, V, Crucitti, L, Stanghellini, Mtl, Assanelli, A, Corti, C, Bernardi, M, Peccatori, J, Bonini, C, Bost, Da, Ciceri, F, and Fleischhauer, K

Published
2013

44. Modeling Antileukemic Adoptive immunotherapy In Mouse-Humans Chimeras To Identify Novel Mechanisms Of Cancer Immunoediting

Author

Oliveira G, Toffalori C, Garcia-Manteiga JM, Camisa B, Crucitti L, Lazarevic D, Peccatori J, Bernardi M, Bordignon C, Bondanza A, Stupka E, Ciceri F, Fleischhauer K, Bonini C, Vago L, Oliveira, G, Toffalori, C, Garcia-Manteiga, Jm, Camisa, B, Crucitti, L, Lazarevic, D, Peccatori, J, Bernardi, M, Bordignon, C, Bondanza, A, Stupka, E, Ciceri, F, Fleischhauer, K, Bonini, C, and Vago, L

Published
2013

45. Non-Linear Clonal Evolution Of Leukemia Driven By Selective Immune Pressure and Revealed By HLA Typing and High-Depth Exome Sequencing

Author

Vago L, Cittaro D, Lazarevic D, Toffalori C, Oliveira G, Chiesa L, Mazzi B, Ponzoni M, Carrabba M, Bernardi M, Peccatori J, Bordignon C, Bonini C, Fleischhauer K, Ciceri F, Stupka E, Vago, L, Cittaro, D, Lazarevic, D, Toffalori, C, Oliveira, G, Chiesa, L, Mazzi, B, Ponzoni, M, Carrabba, M, Bernardi, M, Peccatori, J, Bordignon, C, Bonini, C, Fleischhauer, K, Ciceri, F, and Stupka, E

Published
2013

46. MODELING LEUKEMIA IMMUNOEDITING IN MOUSE-HUMAN CHIMERAS

Author

Oliveira G, Toffalori C, Garcia-Manteiga JM, Camisa B, Crucitti L, Lazarevic D, Peccatori J, Bernardi M, Bordignon C, Bondanza A, Stupka E, Ciceri F, Fleischhauer K, Bonini C, Vago L, Oliveira, G, Toffalori, C, Garcia-Manteiga, Jm, Camisa, B, Crucitti, L, Lazarevic, D, Peccatori, J, Bernardi, M, Bordignon, C, Bondanza, A, Stupka, E, Ciceri, F, Fleischhauer, K, Bonini, C, and Vago, L

Published
2013

49. The torsion free part of the Ziegler spectrum of RG when R is a Dedekind domain and G is a finite group

Author

Marcja, A., Toffalori, C., and Prest, M.

Subjects
Lattice theory -- Analysis, Symbolic and mathematical logic -- Analysis, Mathematical logic -- Analysis, Mathematics
Abstract

The Ziegler spectrum Zg (sub RG) of a group ring RG, where R is a Dedekind domain of characteristic 0 and G is a finite group, particularly the R-torsion free points of Zg (sub RG), is discussed. The role of the RG-lattices (that is, finitely generated R-torsionfree RG-modules) within the spectrum is analyzed.

Published
2002

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