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1. The Medical Segmentation Decathlon

Author

Antonelli, Michela, Reinke, Annika, Bakas, Spyridon, Farahani, Keyvan, AnnetteKopp-Schneider, Landman, Bennett A., Litjens, Geert, Menze, Bjoern, Ronneberger, Olaf, Summers, Ronald M., van Ginneken, Bram, Bilello, Michel, Bilic, Patrick, Christ, Patrick F., Do, Richard K. G., Gollub, Marc J., Heckers, Stephan H., Huisman, Henkjan, Jarnagin, William R., McHugo, Maureen K., Napel, Sandy, Pernicka, Jennifer S. Goli, Rhode, Kawal, Tobon-Gomez, Catalina, Vorontsov, Eugene, Meakin, James A., Ourselin, Sebastien, Wiesenfarth, Manuel, Arbelaez, Pablo, Bae, Byeonguk, Chen, Sihong, Daza, Laura, Feng, Jianjiang, He, Baochun, Isensee, Fabian, Ji, Yuanfeng, Jia, Fucang, Kim, Namkug, Kim, Ildoo, Merhof, Dorit, Pai, Akshay, Park, Beomhee, Perslev, Mathias, Rezaiifar, Ramin, Rippel, Oliver, Sarasua, Ignacio, Shen, Wei, Son, Jaemin, Wachinger, Christian, Wang, Liansheng, Wang, Yan, Xia, Yingda, Xu, Daguang, Xu, Zhanwei, Zheng, Yefeng, Simpson, Amber L., Maier-Hein, Lena, and Cardoso, M. Jorge

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, 68T07
Abstract

International challenges have become the de facto standard for comparative assessment of image analysis algorithms given a specific task. Segmentation is so far the most widely investigated medical image processing task, but the various segmentation challenges have typically been organized in isolation, such that algorithm development was driven by the need to tackle a single specific clinical problem. We hypothesized that a method capable of performing well on multiple tasks will generalize well to a previously unseen task and potentially outperform a custom-designed solution. To investigate the hypothesis, we organized the Medical Segmentation Decathlon (MSD) - a biomedical image analysis challenge, in which algorithms compete in a multitude of both tasks and modalities. The underlying data set was designed to explore the axis of difficulties typically encountered when dealing with medical images, such as small data sets, unbalanced labels, multi-site data and small objects. The MSD challenge confirmed that algorithms with a consistent good performance on a set of tasks preserved their good average performance on a different set of previously unseen tasks. Moreover, by monitoring the MSD winner for two years, we found that this algorithm continued generalizing well to a wide range of other clinical problems, further confirming our hypothesis. Three main conclusions can be drawn from this study: (1) state-of-the-art image segmentation algorithms are mature, accurate, and generalize well when retrained on unseen tasks; (2) consistent algorithmic performance across multiple tasks is a strong surrogate of algorithmic generalizability; (3) the training of accurate AI segmentation models is now commoditized to non AI experts.

Published
2021
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2. Extracellular Volume Fraction by Computed Tomography Predicts Long-Term Prognosis Among Patients With Cardiac Amyloidosis

Author

Gama, Francisco, Rosmini, Stefania, Bandula, Steve, Patel, Kush P., Massa, Paolo, Tobon-Gomez, Catalina, Ecke, Karolin, Stroud, Tyler, Condron, Mark, Thornton, George D., Bennett, Jonathan B., Wechelakar, Ashutosh, Gillmore, Julian D., Whelan, Carol, Lachmann, Helen, Taylor, Stuart A., Pugliese, Francesca, Fontana, Marianna, Moon, James C., Hawkins, Philip N., and Treibel, Thomas A.

Published
2022
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3. The Medical Segmentation Decathlon

Author

Antonelli, Michela, Reinke, Annika, Bakas, Spyridon, Farahani, Keyvan, Kopp-Schneider, Annette, Landman, Bennett A., Litjens, Geert, Menze, Bjoern, Ronneberger, Olaf, Summers, Ronald M., van Ginneken, Bram, Bilello, Michel, Bilic, Patrick, Christ, Patrick F., Do, Richard K. G., Gollub, Marc J., Heckers, Stephan H., Huisman, Henkjan, Jarnagin, William R., McHugo, Maureen K., Napel, Sandy, Pernicka, Jennifer S. Golia, Rhode, Kawal, Tobon-Gomez, Catalina, Vorontsov, Eugene, Meakin, James A., Ourselin, Sebastien, Wiesenfarth, Manuel, Arbeláez, Pablo, Bae, Byeonguk, Chen, Sihong, Daza, Laura, Feng, Jianjiang, He, Baochun, Isensee, Fabian, Ji, Yuanfeng, Jia, Fucang, Kim, Ildoo, Maier-Hein, Klaus, Merhof, Dorit, Pai, Akshay, Park, Beomhee, Perslev, Mathias, Rezaiifar, Ramin, Rippel, Oliver, Sarasua, Ignacio, Shen, Wei, Son, Jaemin, Wachinger, Christian, Wang, Liansheng, Wang, Yan, Xia, Yingda, Xu, Daguang, Xu, Zhanwei, Zheng, Yefeng, Simpson, Amber L., Maier-Hein, Lena, and Cardoso, M. Jorge

Published
2022
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4. Unfolded Cylindrical Projection for Rib Fracture Diagnosis

Author

Tobon-Gomez, Catalina, Stroud, Tyler, Cameron, John, Elcock, Dave, Murray, Andrew, Wyeth, Daniel, Conway, Chris, Reynolds, Steven, Teixeira, Pedro Augusto Gondim, Blum, Alain, Plakas, Costas, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Glocker, Ben, editor, Yao, Jianhua, editor, Vrtovec, Tomaž, editor, Frangi, Alejandro, editor, and Zheng, Guoyan, editor

Published
2018
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6. Towards Left Ventricular Scar Localisation Using Local Motion Descriptors

Author

Peressutti, Devis, Bai, Wenjia, Shi, Wenzhe, Tobon-Gomez, Catalina, Jackson, Thomas, Sohal, Manav, Rinaldi, Aldo, Rueckert, Daniel, King, Andrew, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Camara, Oscar, editor, Mansi, Tommaso, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2016
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7. Quantification of Gaps in Ablation Lesions Around the Pulmonary Veins in Delayed Enhancement MRI

Author

Nuñez Garcia, Marta, Tobon-Gomez, Catalina, Rhode, Kawal, Bijnens, Bart, Camara, Oscar, Butakoff, Constantine, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, van Assen, Hans, editor, Bovendeerd, Peter, editor, and Delhaas, Tammo, editor

Published
2015
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8. Left Atrial Segmentation Challenge: A Unified Benchmarking Framework

Author

Tobon-Gomez, Catalina, Peters, Jochen, Weese, Juergen, Pinto, Karen, Karim, Rashed, Schaeffter, Tobias, Razavi, Reza, Rhode, Kawal S., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Camara, Oscar, editor, Mansi, Tommaso, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2014
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9. Unfolded Cylindrical Projection for Rib Fracture Diagnosis

Author

Tobon-Gomez, Catalina, primary, Stroud, Tyler, additional, Cameron, John, additional, Elcock, Dave, additional, Murray, Andrew, additional, Wyeth, Daniel, additional, Conway, Chris, additional, Reynolds, Steven, additional, Teixeira, Pedro Augusto Gondim, additional, Blum, Alain, additional, and Plakas, Costas, additional

Published
2018
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11. Atlas Construction for Cardiac Velocity Profiles Segmentation Using a Lumped Computational Model of Circulatory System

Author

Baličević, Vedrana, Kalinić, Hrvoje, Lončarić, Sven, Čikeš, Maja, Palau-Caballero, Georgina, Tobon-Gomez, Catalina, Bijnens, Bart H., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ourselin, Sébastien, editor, Rueckert, Daniel, editor, and Smith, Nicolas, editor

Published
2013
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12. Improving Clinical Translation of Cardiovascular Circulatory Models through an Intuitive Graphical User Interface to CircAdapt, Presenting Simulation Results as Clinical Images and Signals

Author

Palau-Caballero, Georgina, Tobon-Gomez, Catalina, Balicevic, Vedrana, Butakoff, Constantine, Loncaric, Sven, Sitges, Marta, Bijnens, Bart H., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Camara, Oscar, editor, Mansi, Tommaso, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2013
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13. Exercise Induced Inter-individual Variation of Right Ventricular Pressures: Simulations Using a Modular Model of the Cardiovascular System

Author

Tobon-Gomez, Catalina, Palau-Caballero, Georgina, Sitges, Marta, Bijnens, Bart H., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Camara, Oscar, editor, Mansi, Tommaso, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2013
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14. A Multimodal Database for the 1 st Cardiac Motion Analysis Challenge

Author

Tobon-Gomez, Catalina, De Craene, Mathieu, Dahl, Annette, Kapetanakis, Stam, Carr-White, Gerry, Lutz, Anja, Rasche, Volker, Etyngier, Patrick, Kozerke, Sebastian, Schaeffter, Tobias, Riccobene, Chiara, Martelli, Yves, Camara, Oscar, Frangi, Alejandro F., Rhode, Kawal S., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Camara, Oscar, editor, Konukoglu, Ender, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2012
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15. Temporal Diffeomorphic Free Form Deformation (TDFFD) Applied to Motion and Deformation Quantification of Tagged MRI Sequences

Author

De Craene, Mathieu, Tobon-Gomez, Catalina, Butakoff, Constantine, Duchateau, Nicolas, Piella, Gemma, Rhode, Kawal S., Frangi, Alejandro F., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Camara, Oscar, editor, Konukoglu, Ender, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2012
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16. Atlas Construction and Image Analysis Using Statistical Cardiac Models

Author

De Craene, Mathieu, Sukno, Federico M., Tobon-Gomez, Catalina, Butakoff, Constantine, Figueras i Ventura, Rosa M., Hoogendoorn, Corné, Piella, Gemma, Duchateau, Nicolas, Muñoz-Moreno, Emma, Sebastian, Rafael, Camara, Oscar, Frangi, Alejandro F., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Camara, Oscar, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, Smith, Nic, editor, and Young, Alistair, editor

Published
2010
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17. Automatic Cardiac MRI Segmentation Using a Biventricular Deformable Medial Model

Author

Sun, Hui, Frangi, Alejandro F., Wang, Hongzhi, Sukno, Federico M., Tobon-Gomez, Catalina, Yushkevich, Paul A., Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Pandu Rangan, C., Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Jiang, Tianzi, editor, Navab, Nassir, editor, Pluim, Josien P. W., editor, and Viergever, Max A., editor

Published
2010
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19. The Medical Segmentation Decathlon

Author

Antonelli, Michela; https://orcid.org/0000-0002-3005-4523, Reinke, Annika; https://orcid.org/0000-0003-4363-1876, Bakas, Spyridon; https://orcid.org/0000-0001-8734-6482, Farahani, Keyvan, Kopp-Schneider, Annette; https://orcid.org/0000-0002-1810-0267, Landman, Bennett A; https://orcid.org/0000-0001-5733-2127, Litjens, Geert; https://orcid.org/0000-0003-1554-1291, Menze, Bjoern; https://orcid.org/0000-0003-4136-5690, Ronneberger, Olaf, Summers, Ronald M, van Ginneken, Bram, Bilello, Michel; https://orcid.org/0000-0001-6313-5437, Bilic, Patrick, Christ, Patrick F, Do, Richard K G; https://orcid.org/0000-0002-6554-0310, Gollub, Marc J; https://orcid.org/0000-0002-6008-0730, Heckers, Stephan H, Huisman, Henkjan; https://orcid.org/0000-0001-6753-3221, Jarnagin, William R, McHugo, Maureen K, Napel, Sandy; https://orcid.org/0000-0002-6876-5507, Pernicka, Jennifer S Golia; https://orcid.org/0000-0002-1076-7948, Rhode, Kawal, Tobon-Gomez, Catalina, Vorontsov, Eugene; https://orcid.org/0000-0002-4530-533X, Meakin, James A, Ourselin, Sébastien; https://orcid.org/0000-0002-5694-5340, Wiesenfarth, Manuel, Arbeláez, Pablo, Bae, Byeonguk; https://orcid.org/0000-0003-2309-8517, et al, Antonelli, Michela; https://orcid.org/0000-0002-3005-4523, Reinke, Annika; https://orcid.org/0000-0003-4363-1876, Bakas, Spyridon; https://orcid.org/0000-0001-8734-6482, Farahani, Keyvan, Kopp-Schneider, Annette; https://orcid.org/0000-0002-1810-0267, Landman, Bennett A; https://orcid.org/0000-0001-5733-2127, Litjens, Geert; https://orcid.org/0000-0003-1554-1291, Menze, Bjoern; https://orcid.org/0000-0003-4136-5690, Ronneberger, Olaf, Summers, Ronald M, van Ginneken, Bram, Bilello, Michel; https://orcid.org/0000-0001-6313-5437, Bilic, Patrick, Christ, Patrick F, Do, Richard K G; https://orcid.org/0000-0002-6554-0310, Gollub, Marc J; https://orcid.org/0000-0002-6008-0730, Heckers, Stephan H, Huisman, Henkjan; https://orcid.org/0000-0001-6753-3221, Jarnagin, William R, McHugo, Maureen K, Napel, Sandy; https://orcid.org/0000-0002-6876-5507, Pernicka, Jennifer S Golia; https://orcid.org/0000-0002-1076-7948, Rhode, Kawal, Tobon-Gomez, Catalina, Vorontsov, Eugene; https://orcid.org/0000-0002-4530-533X, Meakin, James A, Ourselin, Sébastien; https://orcid.org/0000-0002-5694-5340, Wiesenfarth, Manuel, Arbeláez, Pablo, Bae, Byeonguk; https://orcid.org/0000-0003-2309-8517, and et al

Abstract

International challenges have become the de facto standard for comparative assessment of image analysis algorithms. Although segmentation is the most widely investigated medical image processing task, the various challenges have been organized to focus only on specific clinical tasks. We organized the Medical Segmentation Decathlon (MSD)—a biomedical image analysis challenge, in which algorithms compete in a multitude of both tasks and modalities to investigate the hypothesis that a method capable of performing well on multiple tasks will generalize well to a previously unseen task and potentially outperform a custom-designed solution. MSD results confirmed this hypothesis, moreover, MSD winner continued generalizing well to a wide range of other clinical problems for the next two years. Three main conclusions can be drawn from this study: (1) state-of-the-art image segmentation algorithms generalize well when retrained on unseen tasks; (2) consistent algorithmic performance across multiple tasks is a strong surrogate of algorithmic generalizability; (3) the training of accurate AI segmentation models is now commoditized to scientists that are not versed in AI model training.

Published
2022

27. Automatic construction of 3D-ASM intensity models by simulating image acquisition: application to myocardial gated SPECT studies

Author

Tobon-Gomez, Catalina, Butakoff, Constantine, Aguade, Santiago, Sukno, Federico, Moragas, Gloria, and Frangi, Alejandro F.

Subjects
Diagnostic imaging -- Methods, Diagnostic imaging -- Health aspects, Diagnostic imaging -- Models, Heart -- Medical examination, Business, Electronics, Electronics and electrical industries, Health care industry
Abstract

Active shape models bear a great promise for model-based medical image analysis. Their practical use, though, is undermined due to the need to train such models on large image databases. Automatic building of point distribution models (PDMs) has been successfully addressed and a number of autolandmarking techniques are currently available. However, the need for strategies to automatically build intensity models around each landmark has been largely overlooked in the literature. This work demonstrates the potential of creating intensity models automatically by simulating image generation. We show that it is possible to reuse a 3D PDM built from computed tomography (CT) to segment gated single photon emission computed tomography (gSPECT) studies. Training is performed on a realistic virtual population where image acquisition and formation have been modeled using the SIMIND Monte Carlo simulator and ASPIRE image reconstruction software, respectively. The dataset comprised 208 digital phantoms (4D-NCAT) and 20 clinical studies. The evaluation is accomplished by comparing point-to-surface and volume errors against a proper gold standard. Results show that gSPECT studies can be successfully segmented by models trained under this scheme with subvoxel accuracy. The accuracy in estimated LV function parameters, such as end diastolic volume, end systolic volume, and ejection fraction, ranged from 90.0% to 94.5% for the virtual population and from 87.0% to 89.5% for the clinical population. Index Terms--Automatic model building, gated SPECT, intensity model, NCAT, SIMIND, 3D active shape model (ASM).

Published
2008

31. Standardised computed tomographic assessment of left atrial morphology and tissue thickness in humans

Author

Whitaker, John, primary, Karády, Júlia, additional, Karim, Rashed, additional, Tobon-Gomez, Catalina, additional, Fastl, Thomas, additional, Razeghi, Orod, additional, O'Neill, Louisa, additional, Decroocq, Marie, additional, Williams, Steven, additional, Corrado, Cesare, additional, Mukherjee, Rahul K., additional, Sim, Iain, additional, O'Hare, Daniel, additional, Kotadia, Irum, additional, Kolossváry, Márton, additional, Merkely, Bela, additional, Littvay, Levente, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Voros, Szilard, additional, Razavi, Reza, additional, O'Neill, Mark, additional, Rajani, Ronak, additional, Maurovich Horvat, Pál, additional, and Niederer, Steven, additional

Published
2021
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33. A Multimodal Database for the 1 st Cardiac Motion Analysis Challenge

Author

Tobon-Gomez, Catalina, primary, De Craene, Mathieu, additional, Dahl, Annette, additional, Kapetanakis, Stam, additional, Carr-White, Gerry, additional, Lutz, Anja, additional, Rasche, Volker, additional, Etyngier, Patrick, additional, Kozerke, Sebastian, additional, Schaeffter, Tobias, additional, Riccobene, Chiara, additional, Martelli, Yves, additional, Camara, Oscar, additional, Frangi, Alejandro F., additional, and Rhode, Kawal S., additional

Published
2012
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35. Atlas Construction and Image Analysis Using Statistical Cardiac Models

Author

De Craene, Mathieu, primary, Sukno, Federico M., additional, Tobon-Gomez, Catalina, additional, Butakoff, Constantine, additional, Figueras i Ventura, Rosa M., additional, Hoogendoorn, Corné, additional, Piella, Gemma, additional, Duchateau, Nicolas, additional, Muñoz-Moreno, Emma, additional, Sebastian, Rafael, additional, Camara, Oscar, additional, and Frangi, Alejandro F., additional

Published
2010
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37. Cardiac injuries in blunt chest trauma

Author

Tobon-Gomez Catalina, Huguet Marina, Bijnens Bart H, Frangi Alejandro F, and Petit Marius

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Blunt chest traumas are a clinical challenge, both for diagnosis and treatment. The use of Cardiovascular Magnetic Resonance can play a major role in this setting. We present two cases: a 12-year-old boy and 45-year-old man. Late gadolinium enhancement imaging enabled visualization of myocardial damage resulting from the trauma.

Published
2009
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38. Influence of dynamic obstruction and hypertrophy location on diastolic function in hypertrophic cardiomyopathy

Author

Ricardo Ronderos, Mario Petit, Jorge Thierer, Marina Huguet, J. Pablo Costabel, Tobon-Gomez Catalina, A. F. Frangi, Gustavo Avegliano, Marcelo Trivi, and Bart Bijnens

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Heart Ventricles, Diastole, Concentric hypertrophy, Left ventricular hypertrophy, Ventricular Function, Left, Ventricular Outflow Obstruction, Muscle hypertrophy, Ventricular Dysfunction, Left, Young Adult, Tissue Doppler echocardiography, Internal medicine, medicine, Humans, Prospective Studies, cardiovascular diseases, Aged, Aged, 80 and over, medicine.diagnostic_test, Genetic heterogeneity, business.industry, Hypertrophic cardiomyopathy, Magnetic resonance imaging, Organ Size, General Medicine, Cardiomyopathy, Hypertrophic, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Echocardiography, Doppler, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Blood Flow Velocity
Abstract

Background Hypertrophic cardiomyopathy (HCM) is a disease with marked genetic and phenotypic heterogeneity. It is well known that obstructive septal forms of this disease entail worse clinical outcome compared with nonobstructive septal and apical forms. The objective of this study was to analyze the differences in left ventricular diastolic function in different subgroups of HCMs and to assess the influence of the location of myocardial hypertrophy and the presence of dynamic obstruction on impairment of diastolic function and its correlation with the clinical status. Methods We studied 86 patients with HCM; 27 with the obstructive asymmetric septal type (OAS), 37 with the nonobstructive asymmetric septal type (NOAS) and 22 with apical hypertrophic cardiomyopathy (ApHCM). Patients underwent conventional and tissue Doppler echocardiography and were assessed applying the latest recommendations regarding diastolic dysfunction. Cardiac magnetic resonance was used to study the various morphologic subtypes and quantify left ventricular mass (LVM). Results The early diastolic annular velocity (e′) was significantly lower in OAS with a median of 5 cm/s compared with NOAS with 7 cm/s and ApHCM with 7.5 cm/s (P = 0.0002), and the E/e′ ratio was 8.5 in ApHCM, 10 in NOAS and 14 in OAS (P = 0.0001); no significant differences were found in LVM or maximal wall thickness. Conclusion In HCM, the location of left ventricular hypertrophy and the presence of dynamic obstruction affect the degree of diastolic dysfunction; impairment is greater in patients with the OAS type, and markedly less in patients with apical involvement.

Published
2014

39. CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study

Author

Pachajoa, Diana C., Tobon Gomez, Catalina, Ugarte, Juan P., Saiz, Javier, Pachajoa, Diana C., Tobon Gomez, Catalina, Ugarte, Juan P., and Saiz, Javier

Abstract

Exposure to air pollutants like carbon monoxide (CO), lead (Pb++) and sulfur dioxide (SO2) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb++ and SO2 block L-type calcium channels, reducing the calcium current (ICaL) and the action potential duration (APD), which favors the initiation of atrial arrhythmias. The goal is to study the effects of CO, Pb++ and SO2 at different concentrations on ICaL and action potential using computational simulation. For this purpose, models of the effects of the air pollutants on the atrial L-type calcium channel were developed and were incorporated into a mathematical model of a human atrial cell. The results suggest that CO, Pb++ and SO2 block the ICaL current in a fraction that increases along with the concentration, generating an APD shortening. These results are consistent with experimental studies. The combined effect of the three air pollutants produced an APD shortening, which is considered to be a pro-arrhythmic effect., La exposición a contaminantes atmosféricos, como el monóxido de carbono (CO), plomo (Pb++) y dióxido de azufre (SO2), promueve la aparición de enfermedades cardiovasculares. Estudios experimentales han demostrado que el CO, el Pb++ y el SO2 bloquean los canales de calcio tipo L, disminuyendo la corriente de calcio (ICaL) y la duración del potencial de acción (APD), favoreciendo el inicio de arritmias auriculares. El objetivo es estudiar los efectos del CO, Pb++ y SO2 a diferentes concentraciones, sobre ICaL y el potencial de acción auricular mediante simulación computacional. Para ello, se desarrollaron modelos matemáticos de los efectos de los contaminantes atmosféricos sobre el canal de calcio auricular tipo L y se incorporaron en un modelo matemático de células auriculares humanas. Los resultados sugieren que el CO, el Pb++ y el SO2, bloquean la corriente ICaL en una fracción que aumenta a medida que aumenta, la concentración, generando un acortamiento del APD. Estos resultados son consistentes con estudios experimentales. El efecto combinado de los tres contaminantes atmosféricos generó un acortamiento del APD, lo cual es considerado un efecto pro-arrítmico.

Published
2017

41. Personalized Modeling Pipeline for Left Atrial Electromechanics

Author

Fastl, Thomas E, primary, Tobon-Gomez, Catalina, additional, Crozier, William A, additional, Whitaker, John, additional, Rajani, Ronak, additional, McCarthy, Karen P, additional, Sanchez-Quintana, Damian, additional, Ho, Siew Y, additional, O'Neill, Mark D, additional, Plank, Gernot, additional, Bishop, Martin J, additional, and Niederer, Steven A, additional

Published
2016
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42. Utility of Real Time 3D Echocardiography for the Assessment of Left Ventricular Mass in Patients with Hypertrophic Cardiomyopathy: Comparison with Cardiac Magnetic Resonance

Author

Avegliano, Gustavo P., primary, Costabel, Juan P., additional, Asch, Federico M., additional, Sciancalepore, Agustina, additional, Kuschnir, Paola, additional, Huguet, Marina, additional, Tobon-Gomez, Catalina, additional, Frangi, Alejandro F., additional, and Ronderos, Ricardo, additional

Published
2015
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44. Benchmark for Algorithms Segmenting the Left Atrium From 3D CT and MRI Datasets

Author

Tobon-Gomez, Catalina, primary, Geers, Arjan J., additional, Peters, Jochen, additional, Weese, Jurgen, additional, Pinto, Karen, additional, Karim, Rashed, additional, Ammar, Mohammed, additional, Daoudi, Abdelaziz, additional, Margeta, Jan, additional, Sandoval, Zulma, additional, Stender, Birgit, additional, Zheng, Yefeng, additional, Zuluaga, Maria A., additional, Betancur, Julian, additional, Ayache, Nicholas, additional, Chikh, Mohammed Amine, additional, Dillenseger, Jean-Louis, additional, Kelm, B. Michael, additional, Mahmoudi, Said, additional, Ourselin, Sebastien, additional, Schlaefer, Alexander, additional, Schaeffter, Tobias, additional, Razavi, Reza, additional, and Rhode, Kawal S., additional

Published
2015
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45. Myocardial tissue characterization by cardiac magnetic resonance imaging using T1 mapping predicts ventricular arrhythmia in ischemic and non–ischemic cardiomyopathy patients with implantable cardioverter-defibrillators

Author

Chen, Zhong, primary, Sohal, Manav, additional, Voigt, Tobias, additional, Sammut, Eva, additional, Tobon-Gomez, Catalina, additional, Child, Nick, additional, Jackson, Tom, additional, Shetty, Anoop, additional, Bostock, Julian, additional, Cooklin, Michael, additional, O’Neill, Mark, additional, Wright, Matthew, additional, Murgatroyd, Francis, additional, Gill, Jaswinder, additional, Carr-White, Gerry, additional, Chiribiri, Amedeo, additional, Schaeffter, Tobias, additional, Razavi, Reza, additional, and Rinaldi, C. Aldo, additional

Published
2015
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47. Realistic Simulation of Local Image Appearance of Cardiac Magnetic Resonance Imaging Using a Virtual Phantom Population

Author

Tobon-Gomez, Catalina, Sukno, Federico, Bijnens, Bart H., Huguet, Marina, Frangi, Alejandro, Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra [Barcelona] (UPF), Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III [Madrid] (ISC)-ministerio de ciencia e innovacion, CETIR Grup Sant Jordi [Barcelona] (CETIR Grup), CETIR Grup, Institució Catalana de Recerca i Estudis Avançats (ICREA), Session 04 : Device Delivery, Surgery Planning, and Future Directions, and Monteil, Alain

Subjects
[INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Abstract

International audience; Magnetic resonance imaging (MRI) simulators have been largely applied to brain studies. However, cardiac applications of these simulators are only emerging. This paper focuses on the realistic simulation of local appearance of cardiac MRI datasets. Simulations are obtained from the MRISIM simulator with XCAT phantom (formerly NCAT) as input. Phantoms are further extended to increase realism of the local appearance of the simulated datasets. The extension is based on: resemblance of partial volume effect by using a higher resolution phantom as input to the simulator, addition of intensity variability of each tissue by increasing the number of labels of the phantom, and inclusion of trabeculae in the ventricular cavities. The clinical database included 40 patients for anatomical measurements and 5 healthy athletes for local grey value statistics. The virtual database included 20 digital phantoms. Histograms from different tissues were obtained from the real datasets and compared to histograms of the simulated datasets by means of Chi-square dissimilarity metric. The addition of sublabels and trabeculae improved the matching of real histograms in 8 out of 11 comparisons. Simulated intensity distributions were improved up to 76% with respect to the original distributions. Our methodology obtained a higher dissimilarity metric for lung and pericardial tissue.

Published
2009

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