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314 results on '"Tobita, T."'

9. LEAP projects: Concept and challenges

Author

Manzari, M, primary, Kutter, B, additional, Zeghal, M, additional, Iai, S, additional, Tobita, T, additional, Madabhushi, S, additional, Haigh, S, additional, Mejia, L, additional, Gutierrez, D, additional, Armstrong, R, additional, Sharp, M, additional, Chen, Y, additional, and Zhou, Y, additional

Published
2014
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24. Stress-strain response of the LEAP-2015 centrifuge tests and numerical predictions

Author

Zeghal, M, Goswami, N, Kutter, BL, Manzari, MT, Abdoun, T, Arduino, P, Armstrong, R, Beaty, M, Chen, YM, Ghofrani, A, Haigh, S, Hung, WY, Iai, S, Kokkali, P, Lee, CJ, Madabhushi, G, Tobita, T, Ueda, K, Zhou, YG, Ziotopoulou, K, Haigh, Stuart [0000-0003-3782-0099], Madabhushi, Gopal [0000-0003-4031-8761], and Apollo - University of Cambridge Repository

Subjects
4005 Civil Engineering, 4019 Resources Engineering and Extractive Metallurgy, 40 Engineering
Abstract

© 2017. The Liquefaction Experiments and Analysis Projects (LEAP) is an international effort to produce a set of high quality test data and to then use it in a validation exercise of existing computational models and simulation procedures for soil liquefaction analysis. A validation effort (LEAP-GWU 2015) was undertaken using a benchmark centrifuge model of a sloping deposit tested in a rigid-wall container. This article presents and discusses the shear stress-strain responses and effective stress paths of the LEAP-GW 2015 centrifuge tests and numerical predictions (including an assessment of the effects of the rigid boundaries).

Published
2018
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29. SIRT1 disruption in human fetal hepatocytes leads to increased accumulation of glucose and lipids

Author

Tobita, T, Guzman-Lepe, J, Takeishi, K, Nakao, T, Wang, Y, Meng, F, Deng, CX, De L'Hortet, AC, Soto-Gutierrez, A, Tobita, T, Guzman-Lepe, J, Takeishi, K, Nakao, T, Wang, Y, Meng, F, Deng, CX, De L'Hortet, AC, and Soto-Gutierrez, A

Abstract

There are unprecedented epidemics of obesity, such as type II diabetes and non-alcoholic fatty liver diseases (NAFLD) in developed countries. A concerning percentage of American children are being affected by obesity and NAFLD. Studies have suggested that the maternal environment in utero might play a role in the development of these diseases later in life. In this study, we documented that inhibiting SIRT1 signaling in human fetal hepatocytes rapidly led to an increase in intracellular glucose and lipids levels. More importantly, both de novo lipogenesis and gluconeogenesis related genes were upregulated upon SIRT1 inhibition. The AKT/FOXO1 pathway, a major negative regulator of gluconeogenesis, was decreased in the human fetal hepatocytes inhibited for SIRT1, consistent with the higher level of gluconeogenesis. These results indicate that SIRT1 is an important regulator of lipid and carbohydrate metabolisms within human fetal hepatocytes, acting as an adaptive transcriptional response to environmental changes.

Published
2016

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