Search

Your search keyword '"Tobias, Michael"' showing total 1,275 results
Start Over Author "Tobias, Michael"
1,275 results on '"Tobias, Michael"'

2. The ADVanced Organ Support (ADVOS) hemodialysis system removes IL-6: an in vitro proof-of-concept study

Author

Susanne Himmelein, Aritz Perez Ruiz de Garibay, Veronika Brandel, Frank Zierfuß, and Tobias Michael Bingold

Subjects
Extracorporeal blood purification, Albumin dialysis, Multiple organ failure, Advanced organ support, IL-6, Cytokines, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background IL-6 is a pleiotropic cytokine modulating inflammation and metabolic pathways. Its proinflammatory effect plays a significant role in organ failure pathogenesis, commonly elevated in systemic inflammatory conditions. Extracorporeal blood purification devices, such as the Advanced Organ Support (ADVOS) multi hemodialysis system, might offer potential in mitigating IL-6's detrimental effects, yet its efficacy remains unreported. Methods We conducted a proof-of-concept in vitro study to assess the ADVOS multi system's efficacy in eliminating IL-6. Varying concentrations of IL-6 were introduced into a swine blood model and treated with ADVOS multi for up to 12 h, employing different blood and concentrate flow rates. IL-6 reduction rate, clearance, and dynamics in blood and dialysate were analyzed. Results IL-6 clearance rates of 0.70 L/h and 0.42 L/h were observed in 4 and 12-h experiments, respectively. No significant differences were noted across different initial concentrations. Reduction rates ranged between 40 and 46% within the first 4 h, increasing up to 72% over 12 h, with minimal impact from flow rate variations. Our findings suggest that an IL-6-albumin interaction and convective filtration are implicated in in vitro IL-6 elimination with ADVOS multi. Conclusions This study demonstrates for the first time an efficient and continuous in vitro removal of IL-6 by ADVOS multi at low blood flow rates. Initial concentration-dependent removal transitions to more consistent elimination over time. Further clinical investigations are imperative for comprehensive data acquisition.

Published
2024
Full Text
View/download PDF

3. Characterization of Heat Transport and Diffusion Processes During Metal Melt Filtration

Author

Heisig, Lisa-Marie, Markuske, Katrin, Wulf, Rhena, Fieback, Tobias Michael, Hull, Robert, Series Editor, Jagadish, Chennupati, Series Editor, Kawazoe, Yoshiyuki, Series Editor, Kruzic, Jamie, Series Editor, Osgood Jr., Richard, Series Editor, Parisi, Jürgen, Series Editor, Pohl, Udo W., Series Editor, Seong, Tae-Yeon, Series Editor, Uchida, Shin-ichi, Series Editor, Wang, Zhiming M., Series Editor, Aneziris, Christos G., editor, and Biermann, Horst, editor

Published
2024
Full Text
View/download PDF

21. Coda

Author

Tobias, Michael Charles and Tobias, Michael Charles

Published
2022
Full Text
View/download PDF

35. The Last Island

Author

Tobias, Michael Charles, Morrison, Jane Gray, Tobias, Michael Charles, and Morrison, Jane Gray

Published
2021
Full Text
View/download PDF

37. Forgiveness

Author

Tobias, Michael Charles, Morrison, Jane Gray, Tobias, Michael Charles, and Morrison, Jane Gray

Published
2021
Full Text
View/download PDF

41. A Lost Species

Author

Tobias, Michael Charles, Morrison, Jane Gray, Tobias, Michael Charles, and Morrison, Jane Gray

Published
2021
Full Text
View/download PDF

42. Rebirth

Author

Tobias, Michael Charles, Morrison, Jane Gray, Tobias, Michael Charles, and Morrison, Jane Gray

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results