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1. Estenosis arterial del injerto renal: evaluación de la incidencia mediante ecografía doppler, factores de riesgo y análisis de las complicaciones que pueden afectar a la supervivencia del injerto

Author

Calzas Montalvo, C., Medina-Polo, J., Miranda Utrera, N.R., Juste Álvarez, S., de la Calle Moreno, A., Caro González, M.P., Santos Perez de la Blanca, R., Hernández Arroyo, M., Peña Vallejo, E., Teigell Tobar, J., Duarte Ojeda, J.M., Pamplona Casamayor, M., Tejido Sánchez, Á., García González, L., Arrébola Pajares, A., Sánchez Guerrero, Á., Rodríguez de la Calle, J., and Rodríguez Antolín, A.

Published
2024
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2. Transplant renal artery stenosis: Study of incidence using doppler ultrasound, risk factors and analysis is effect in graft outcomes

Author

Calzas Montalvo, C., Medina-Polo, J., Miranda Utrera, N.R., Juste Álvarez, S., de la Calle Moreno, A., Caro González, M.P., Santos Perez de la Blanca, R., Hernández Arroyo, M., Peña Vallejo, E., Teigell Tobar, J., Duarte Ojeda, J.M., Pamplona Casamayor, M., Tejido Sánchez, Á., García González, L., Arrébola Pajares, A., Sánchez Guerrero, Á., Rodríguez de la Calle, J., and Rodríguez Antolín, A.

Published
2024
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3. Grupos de riesgo de recidiva bioquímica tras prostatectomía radical de la Asociación Europea de Urología: validación externa e identificación de factores de riesgo de progresión y mortalidad

Author

Sopeña Sutil, R., Vázquez-Martul, D., de Pablos-Rodríguez, P., Peña Vallejo, E., Altez Fernández, C., Gómez-Ferrer Lozano, A., Téigell Tobar, J., Rollón Prieto, G., Coy García, A., Ramírez Backhaus, M., Chantada Abal, V., and Rodríguez Antolín, A.

Published
2023
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4. European Association of Urology biochemical recurrence risk groups after radical prostatectomy: External validation and identification of independent risk factors for progression and death

Author

Sopeña Sutil, R., Vázquez-Martul, D., De Pablos-Rodríguez, P., Peña Vallejo, E., Altez Fernández, C., Gómez-Ferrer Lozano, A., Téigell Tobar, J., Rollón Prieto, G., Coy García, A., Ramírez Backhaus, M., Chantada Abal, V., and Rodríguez Antolín, A.

Published
2023
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5. Search for toroids in excited nuclear material.

Author

Hannaman, A., Harvey, B., McIntosh, A.B., Hagel, K., Bills, L., Abbott, A., Fentress, A., Gauthier, J., Hankins, T., Lui, Y.-W., McIntosh, L.A., Regener, S., Rider, R., Schultz, S., Sorensen, M.Q., Tobar, J., Tobin, Z., and Yennello, S.

Subjects
TOROIDAL magnetic circuits, RADIOACTIVE substances, HEAVY ion collisions, DATA analysis, UNCERTAINTY
Abstract

Ground state nuclei usually have compact geometries. However, there have been theoretical predictions that excited nuclei can take on more extended shapes such as toroids or bubbles. There have been many attempts to identify signatures of such shapes in experimental data. One signature, both predicted by theory and reported in experimental data, is narrow resonances at high excitation energy in peripheral intermediate-energy heavy-ion collisions. This potential evidence for toroidal states was reported in the alpha particle disassembly of 28Si after collision with a 12C target at 35 MeV/nucleon. The prior work was limited by angular resolution and statistical uncertainties. The present work aims to measure the excitation energy distribution for these disassembly events with improved angular resolution and reduced statistical uncertainty using the Forward Array Using Silicon Technology (FAUST). FAUST is equipped with resistive dual-axis duo-lateral (DADL) position-sensitive silicon detectors capable of sub-millimeter position resolution. The measured excitation energy distributions of 7-α disassembly events showed no strong evidence for highly excited states at the cross section and widths suggested by previous experiment. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Estenosis arterial del injerto renal: evaluación de la incidencia mediante ecografía doppler, factores de riesgo y análisis de las complicaciones que pueden afectar a la supervivencia del injerto

Author

Calzas Montalvo, C., primary, Medina-Polo, J., additional, Miranda Utrera, N.R., additional, Juste Álvarez, S., additional, de la Calle Moreno, A., additional, Caro González, M.P., additional, Santos Perez de la Blanca, R., additional, Hernández Arroyo, M., additional, Peña Vallejo, E., additional, Teigell Tobar, J., additional, Duarte Ojeda, J.M., additional, Pamplona Casamayor, M., additional, Tejido Sánchez, Á., additional, García González, L., additional, Arrébola Pajares, A., additional, Guerrero González, Á., additional, Rodríguez de la Calle, J., additional, and Rodríguez Antolín, A., additional

Published
2023
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8. Antibiotic prophylaxis before urodynamic studies: Are antibiotics required to decrease infections and for which patients would be prophylaxis the most beneficial?

Author

Juste Alvarez, S., primary, Medina-Polo, J., additional, Arrebola Pajares, A., additional, Teigell Tobar, J., additional, Peña Vallejo, E., additional, Calzas Montalvo, C., additional, Caro González, P., additional, De La Calle Moreno, A., additional, García-Rayo Encina, C., additional, González Ginel, I., additional, and Rodríguez Antolín, A., additional

Published
2023
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9. Surgery for stress urinary incontinence in males: Presurgical characteristics, associated complications, changes in continence parameters and quality of life evaluation

Author

Medina Polo, J., primary, Peña Vallejo, H., additional, Teigell Tobar, J., additional, Calzas Montalvo, C., additional, Caro González, M.P., additional, Alonso Isa, M., additional, García Gómez, B., additional, Arrébola Pajares, A., additional, Rodríguez Antolín, A., additional, and Romero Otero, J., additional

Published
2022
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10. Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study

Author

Ruffino, M. A., Chan, S., Coughlin, P., Awopetu, A., Stather, P., Lane, T., Theodosiou, D., Ahmed, M. A., Vasudevan, T., Ibrahim, M., Al Maadany, F., Eljareh, M., Alkhafeefi, F. S., Coscas, R., Unal, E. U., Pulli, R., Zaca, S., Angiletta, D., Kotsis, T., Moawad, M., Tozzi, M., Patelis, N., Lazaris, A. M., Chuen, J., Croo, A., Tsolaki, E., Zenunaj, G., Kamal, D., Tolba, M. M., Maresch, M., Khetarpaul, V., Mills, J., Gangwani, G., Elahwal, M., Khalil, R., Azab, M. A., Mahomed, A., Whiston, R., Contractor, U., Esposito, D., Pratesi, C., Giacomelli, E., Troncoso, M. V., Elkouri, S., Johansson, F. G., Dodos, I., Benezit, M., Vidoedo, J., Rocha-Neves, J., Pereira-Neves, A. H., Dias-Neto, M. F., Campos Jacome, A. F., Loureiro, L., Silva, I., Garza-Herrera, R., Canata, V., Bezard, C., Bowser, K., Tobar, J. F., Vera, C. G., Parra, C. S., Lopez, E., Serra, Y. G., Varela, J., Rubio, V., Victoria, G., Johnson, A., O'Banion, L. A., Makar, R., Tantawy, T. G., Storck, M., Jongkind, V., Falah, O., Mcbride, O., Isik, A., Papaioannou, A., Ocke Reis, P. E., Bracale, U. M., Atkins, E., Tinelli, Giovanni, Scott, E., Wales, L., Sivaharan, A., Priona, G., Nesbitt, C., Grainger, T., Shelmerdine, L., Chong, P., Bajwa, A., Arwynck, L., Hadjievangelou, N., Elbasty, A., Rubio, O., Ricardo, M., Ulloa, J. H., Tarazona, M., Pabon, M., Pitoulias, G., Corless, K., Ioannidis, O., Friedrich, O., Van Herzeele, I., Vijaynagar, B., Cohnert, T., Bell, R., Moore, H., Saha, P., Gifford, E., Laine, M., Barkat, A., Karkos, C., Binti Safri, L. S., Buitron, G., Del Castillo, J., Carrera, P., Salinas, N., Biagioni, R. B., Benites, S., Mafla, C. A., Pian, P. M., Albino, P., Serrano, E., Marin, A., Gonzalez, M., Foreroga, M., Russo, A., Reyes, A., Guglielmone, D., Grillo, L., Flumignan, R., Palones, F. G., Silveira, P. G., Ramely, R. B., Edeiken, S., Chetter, I., Green, L., Sudarsanam, A., Lyons, O., Lemmon, G., Neville, R., Castelli, M., Hinojosa, C. A., Carvajal, R. R., Rivera, A., Wong, P., Drudi, L., Perkins, J., Sieunarine, K., Attia, D., Atef, M., Eftychios, L., Weaver, F., Ren, L. C., Alomari, M., Jamjoom, R., Aljarrah, Q., Abbas, A., Alomran, F., Kumar, A., Altoijri, A., Elsanhoury, K. T., Alhumaid, A., Fekry, T., Sekhar, R., Theodoridis, P., Panagiotis, T., Roditis, K., Tsiantoula, P., Antoniou, A., Soler, R., Hasemaki, N., Baili, E., Mpaili, E., Huasen, B., Wallace, T., Duncan, A., Metcalfe, M., Mannoia, K., Bechara, C. F., Tsilimparis, N., Aranson, N., Riding, D., Palena, M., Mcdonnell, C., Mouawad, N. J., Banegas, S., Rossi, P., Oshodi, T., Diaz, R., Afifi, R., Dindyal, S., Thapar, A., Kordzadeh, A., Pullas, G., Lin, S., Davies, C., Darvall, K., Kodama, A., Gooneratne, T., Gunawansa, N., Munoz, A., Jie, N. J., Bradley, N., Al-Jundi, W., Meyer, F., Lee, C., Malina, M., Renton, S., Lui, D., Batchelder, A., Oszkinis, G., Freyrie, A., Giordano, J., Saratzis, N., Tigkiropoulos, K., Kyriakos, S., Popov, G., Cheema, M. U., Lapolla, P., Ling Patricia, Y. C., Ennab, R., Ullery, B. W., Pasenidou, K., Tam, J., Sidel, G., Jayaprakash, V. V., Bennett, L., Hardy, S., Davies, E., Baker, S., Wijesinghe, L., Tam, A., Mccune, K., Chana, M., Lowe, C., Goh, A., Powezka, K., Kyrou, I., Altaf, N., Harkin, D., Travers, H., Cragg, J., Sharif, A., Akhtar, T., Chavez, J. A., Ordonez, C., Mazzurco, M., Choke, E., Asghar, I., Summerour, V., Dunlop, P., Morley, R., Hardy, T., Bevis, P., Cuff, R., Stavroulakis, K., Beropoulis, E., Argyriou, A., Loftus, I., Azhar, B., Sheth, S., Usai, M. V., Choudhry, A., Nicole, K., Boyle, E., Joyce, D., Abdelaty Hassan, M. H., Saltiel, A., Frahm-Jensen, G., Antoniou, G., Elhadi, M., Kimyaghalam, A., Malgor, R., Telve, D., Isaak, A., Schmidli, J., Mckevitt, K., Siddiqui, T., Asciutto, G., Floros, N., Papadopoulos, G., Kafetzakis, A., Koutsias, S. G., Nana, P., Giannoukas, A., Kakkos, S., Moulakakis, K. G., Shafique, N., Jawien, A., Popplewell, M., Imray, C., Abayasekara, K., Rowlands, T., Kuhan, G., Rajagopalan, S., Jaipersad, A., Sadia, U., Kobe, I., Mittapalli, D., Enemosah, I., Behrendt, C. -A., Beck, A., Almudhafer, M., Ancetti, S., Jacobs, D., Jayakumar, P., Malekpour, F., Shalhub, S., Keldiyorov, B., Simon, M., Khashram, M., Rich, N., Shepherd, A., Meecham, L., Doherty, D., Benson, R. A., Tinelli G. (ORCID:0000-0002-2212-3226), Ruffino, M. A., Chan, S., Coughlin, P., Awopetu, A., Stather, P., Lane, T., Theodosiou, D., Ahmed, M. A., Vasudevan, T., Ibrahim, M., Al Maadany, F., Eljareh, M., Alkhafeefi, F. S., Coscas, R., Unal, E. U., Pulli, R., Zaca, S., Angiletta, D., Kotsis, T., Moawad, M., Tozzi, M., Patelis, N., Lazaris, A. M., Chuen, J., Croo, A., Tsolaki, E., Zenunaj, G., Kamal, D., Tolba, M. M., Maresch, M., Khetarpaul, V., Mills, J., Gangwani, G., Elahwal, M., Khalil, R., Azab, M. A., Mahomed, A., Whiston, R., Contractor, U., Esposito, D., Pratesi, C., Giacomelli, E., Troncoso, M. V., Elkouri, S., Johansson, F. G., Dodos, I., Benezit, M., Vidoedo, J., Rocha-Neves, J., Pereira-Neves, A. H., Dias-Neto, M. F., Campos Jacome, A. F., Loureiro, L., Silva, I., Garza-Herrera, R., Canata, V., Bezard, C., Bowser, K., Tobar, J. F., Vera, C. G., Parra, C. S., Lopez, E., Serra, Y. G., Varela, J., Rubio, V., Victoria, G., Johnson, A., O'Banion, L. A., Makar, R., Tantawy, T. G., Storck, M., Jongkind, V., Falah, O., Mcbride, O., Isik, A., Papaioannou, A., Ocke Reis, P. E., Bracale, U. M., Atkins, E., Tinelli, Giovanni, Scott, E., Wales, L., Sivaharan, A., Priona, G., Nesbitt, C., Grainger, T., Shelmerdine, L., Chong, P., Bajwa, A., Arwynck, L., Hadjievangelou, N., Elbasty, A., Rubio, O., Ricardo, M., Ulloa, J. H., Tarazona, M., Pabon, M., Pitoulias, G., Corless, K., Ioannidis, O., Friedrich, O., Van Herzeele, I., Vijaynagar, B., Cohnert, T., Bell, R., Moore, H., Saha, P., Gifford, E., Laine, M., Barkat, A., Karkos, C., Binti Safri, L. S., Buitron, G., Del Castillo, J., Carrera, P., Salinas, N., Biagioni, R. B., Benites, S., Mafla, C. A., Pian, P. M., Albino, P., Serrano, E., Marin, A., Gonzalez, M., Foreroga, M., Russo, A., Reyes, A., Guglielmone, D., Grillo, L., Flumignan, R., Palones, F. G., Silveira, P. G., Ramely, R. B., Edeiken, S., Chetter, I., Green, L., Sudarsanam, A., Lyons, O., Lemmon, G., Neville, R., Castelli, M., Hinojosa, C. A., Carvajal, R. R., Rivera, A., Wong, P., Drudi, L., Perkins, J., Sieunarine, K., Attia, D., Atef, M., Eftychios, L., Weaver, F., Ren, L. C., Alomari, M., Jamjoom, R., Aljarrah, Q., Abbas, A., Alomran, F., Kumar, A., Altoijri, A., Elsanhoury, K. T., Alhumaid, A., Fekry, T., Sekhar, R., Theodoridis, P., Panagiotis, T., Roditis, K., Tsiantoula, P., Antoniou, A., Soler, R., Hasemaki, N., Baili, E., Mpaili, E., Huasen, B., Wallace, T., Duncan, A., Metcalfe, M., Mannoia, K., Bechara, C. F., Tsilimparis, N., Aranson, N., Riding, D., Palena, M., Mcdonnell, C., Mouawad, N. J., Banegas, S., Rossi, P., Oshodi, T., Diaz, R., Afifi, R., Dindyal, S., Thapar, A., Kordzadeh, A., Pullas, G., Lin, S., Davies, C., Darvall, K., Kodama, A., Gooneratne, T., Gunawansa, N., Munoz, A., Jie, N. J., Bradley, N., Al-Jundi, W., Meyer, F., Lee, C., Malina, M., Renton, S., Lui, D., Batchelder, A., Oszkinis, G., Freyrie, A., Giordano, J., Saratzis, N., Tigkiropoulos, K., Kyriakos, S., Popov, G., Cheema, M. U., Lapolla, P., Ling Patricia, Y. C., Ennab, R., Ullery, B. W., Pasenidou, K., Tam, J., Sidel, G., Jayaprakash, V. V., Bennett, L., Hardy, S., Davies, E., Baker, S., Wijesinghe, L., Tam, A., Mccune, K., Chana, M., Lowe, C., Goh, A., Powezka, K., Kyrou, I., Altaf, N., Harkin, D., Travers, H., Cragg, J., Sharif, A., Akhtar, T., Chavez, J. A., Ordonez, C., Mazzurco, M., Choke, E., Asghar, I., Summerour, V., Dunlop, P., Morley, R., Hardy, T., Bevis, P., Cuff, R., Stavroulakis, K., Beropoulis, E., Argyriou, A., Loftus, I., Azhar, B., Sheth, S., Usai, M. V., Choudhry, A., Nicole, K., Boyle, E., Joyce, D., Abdelaty Hassan, M. H., Saltiel, A., Frahm-Jensen, G., Antoniou, G., Elhadi, M., Kimyaghalam, A., Malgor, R., Telve, D., Isaak, A., Schmidli, J., Mckevitt, K., Siddiqui, T., Asciutto, G., Floros, N., Papadopoulos, G., Kafetzakis, A., Koutsias, S. G., Nana, P., Giannoukas, A., Kakkos, S., Moulakakis, K. G., Shafique, N., Jawien, A., Popplewell, M., Imray, C., Abayasekara, K., Rowlands, T., Kuhan, G., Rajagopalan, S., Jaipersad, A., Sadia, U., Kobe, I., Mittapalli, D., Enemosah, I., Behrendt, C. -A., Beck, A., Almudhafer, M., Ancetti, S., Jacobs, D., Jayakumar, P., Malekpour, F., Shalhub, S., Keldiyorov, B., Simon, M., Khashram, M., Rich, N., Shepherd, A., Meecham, L., Doherty, D., Benson, R. A., and Tinelli G. (ORCID:0000-0002-2212-3226)

Abstract

Objective: To document the recovery of vascular services in Europe following the first COVID-19 pandemic peak. Methods: An online structured vascular service survey with repeated data entry between 23 March and 9 August 2020 was carried out. Unit level data were collected using repeated questionnaires addressing modifications to vascular services during the first peak (March – May 2020, “period 1”), and then again between May and June (“period 2”) and June and July 2020 (“period 3”). The duration of each period was similar. From 2 June, as reductions in cases began to be reported, centres were first asked if they were in a region still affected by rising cases, or if they had passed the peak of the first wave. These centres were asked additional questions about adaptations made to their standard pathways to permit elective surgery to resume. Results: The impact of the pandemic continued to be felt well after countries’ first peak was thought to have passed in 2020. Aneurysm screening had not returned to normal in 21.7% of centres. Carotid surgery was still offered on a case by case basis in 33.8% of centres, and only 52.9% of centres had returned to their normal aneurysm threshold for surgery. Half of centres (49.4%) believed their management of lower limb ischaemia continued to be negatively affected by the pandemic. Reduced operating theatre capacity continued in 45.5% of centres. Twenty per cent of responding centres documented a backlog of at least 20 aortic repairs. At least one negative swab and 14 days of isolation were the most common strategies used for permitting safe elective surgery to recommence. Conclusion: Centres reported a broad return of services approaching pre-pandemic “normal” by July 2020. Many introduced protocols to manage peri-operative COVID-19 risk. Backlogs in cases were reported for all major vascular surgeries.

Published
2022

14. Transplant renal artery stenosis: Study of incidence using doppler ultrasound, risk factors and analysis effect in graft outcomes

Author

Calzas Montalvo, C., primary, Medina Polo, J., additional, Miranda Utrera, N.R., additional, Caro González, M.P., additional, Santos Perez De La Blanca, R., additional, Hernandez Arroyo, M., additional, Peña Vallejo, E., additional, Teigell Tobar, J., additional, Juste Álvarez, S., additional, De La Calle Moreno, A., additional, Rodriguez Antolín, A., additional, Duarte Ojeda, J.M., additional, Pamplona Casamayor, M., additional, Tejido Sánchez, Á., additional, García González, L., additional, Arrébola Pajares, A., additional, and Rodriguez De La Calle, J., additional

Published
2022
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16. Complications urétérales de la transplantation rénale : incidence, caractéristiques et traitement

Author

Santos pérez de la blanca, R., primary, De la rosa kehrman, F., additional, Tejido sánchez, Á., additional, Peña vallejo, E., additional, Hernández arroyo, M., additional, Teigell tobar, J., additional, Arrebola pajares, A., additional, García gonzález, L., additional, Miranda utrera, N., additional, Medina polo, J., additional, Duarte ojeda, J., additional, Pamplona casamayor, M., additional, and Rodriguez antolin, A., additional

Published
2021
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17. Post-COVID-19 syndrome: prospective evaluation of clinical and functional outcomes

Author

Ybarra Falcon, C, primary, Aparisi, A, additional, Garcia Gomez, M, additional, Iglesias Echeverria, C, additional, Tobar, J, additional, Ladron, R, additional, Uribarri, A, additional, Jaurrieta Largo, S, additional, Catala, P, additional, Hinojosa, W, additional, Veras Burgos, C, additional, Marcos Mangas, M, additional, Carrasco Moraleja, M, additional, Amat Santos, I J, additional, and San Roman Calvar, A, additional

Published
2021
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18. Evaluation of the evolution of antibiotic prescription in the treatment of Healthcare-Associated Infections (HAIs) in a urology ward after implementing a treatment optimisation programme

Author

Medina-Polo, J., primary, Abad-López, P., additional, González-Diaz, A., additional, Santos-Pérez De La Blanca, R., additional, Hernández-Arroyo, M., additional, Teigell-Tobar, J., additional, Peña-Vallejo, H., additional, Calzas-Montalvo, C., additional, Caro-González, M.P., additional, Miranda-Uretra, N., additional, Gil-Moradillo, J., additional, and Tejido-Sánchez, Á., additional

Published
2021
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19. Multi-risk assessment and management—a comparative study of the current state of affairs in chile and ecuador

Author

Greiving, S. (Stefan), Schödl, L. (Leonie), Gaudry, K.-H. (Karl-Heinz), Miralles, I.K.Q. (Iris Katherine Quintana), Larraín, B.P. (Benjamín Prado), Fleischhauer, M. (Mark), Guerra, M.M.J. (Myriam Margoth Jácome), Tobar, J. (Jonathan), Greiving, S. (Stefan), Schödl, L. (Leonie), Gaudry, K.-H. (Karl-Heinz), Miralles, I.K.Q. (Iris Katherine Quintana), Larraín, B.P. (Benjamín Prado), Fleischhauer, M. (Mark), Guerra, M.M.J. (Myriam Margoth Jácome), and Tobar, J. (Jonathan)

Abstract

In Chile and Ecuador, multiple hazards and dynamic processes in vulnerability pose a high risk. Spatial planning and emergency management can contribute to disaster risk management but they follow different goals. However, global goals, such as from UN-ISDR (United Nati

Published
2021
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20. Observational study over 8-year period evaluating microbiological characteristics and risk factor for isolation of multidrug-resistant organisms (MDRO) in patients with healthcare-associated infections (HAIs) hospitalized in a urology ward

Author

Medina-Polo, J, Gil-Moradillo, J, González-Díaz, A, Abad-López, P, Santos-Pérez de la Blanca, R, Hernández-Arroyo, M, Peña-Vallejo, H, Téigell-Tobar, J, Calzas-Montalvo, C, Caro-González, P, Miranda-Utrera, N, Tejido-Sánchez, Á, Medina-Polo, J, Gil-Moradillo, J, González-Díaz, A, Abad-López, P, Santos-Pérez de la Blanca, R, Hernández-Arroyo, M, Peña-Vallejo, H, Téigell-Tobar, J, Calzas-Montalvo, C, Caro-González, P, Miranda-Utrera, N, and Tejido-Sánchez, Á

Abstract

Objective: To analyze, in a urology ward, the prevalence and characteristics of healthcare-associated infections (HAIs) due to multidrug-resistant organisms (MDRO).Methods: We carried out an observational study from 2012 to 2019, evaluating MDRO among patients with HAIs, who were hospitalized in the urology ward. MDRO include Pseudomonas spp., resistant to at least three antibiotic groups, extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae or those resistant to carbapenems, and Enterococcus spp. resistant to vancomycin.Results: Among patients with HAIs, MDRO were isolated in 100 out of 438 (22.8%) positive cultures. Univariate and multivariate analyses reported that prior urinary tract infection (UTI) [OR 2.45; 95% CI 1.14-5.36; p=0.021] and immunosuppression [OR 2.13; 95% CI 1.11-4.10; p=0.023] were risk factors for MDRO. A high prevalence of MRDO was found in patients with a catheter in the upper urinary tract; 27.6% for double J stent, 29.6% in those with a nephrostomy tube, and 50% in those with a percutaneous internal/external nephroureteral (PCNU) stent. MDRO were isolated in 28.4% of cultures with Enterobacteriaceae (23.8% and 44.7% in those with E. coli and Klebsiella spp.); 7% of Enterobacteriaceae showed resistance to carbapenems (1.3% and 10% for E. coli and Klebsiella spp., respectively). Three out of 80 Enterococcus spp. were vancomycin-resistant. The rate of Pseudomonas aeruginosa resistant to at least three antibiotic groups was 36.3%.Conclusions: The isolation of MDRO, in up to 25% of positive cultures in a urology ward, constitutes a challenge for the selection of antibiotics. MDRO are more common in immunosuppressed patients, those with previous UTIs, and those with a catheter in the upper urinary tract.

Published
2021

21. Transformations in the Ecuadorian scientific landscape:A bibliometric analysis of the main publications trends and the role of the scientific networks and the public international scholarship program

Author

Chavez, Henry, Gaybor Tobar, J (Jacqueline), Chavez, Henry, and Gaybor Tobar, J (Jacqueline)

Abstract

Like other Latin American countries, Ecuador has undergone major political and economic transformations in the last decade. Science, technology and innovation policies were at the core of some of these transformations. Despite the economic recession since 2015, the local techno-scientific landscape has experienced quantitative and qualitative transformations that need to be analyzed. This paper aims to shed light on these changes and on the Ecuadorian techno-scientific system, which so far remains under-researched. To do so, we first carry out a bibliometric analysis of more than 25,000 records with Ecuadorian affiliation from the Scopus database, published between 1920 and 2019. This allows us to reconstruct the growing complexity of local techno-scientific networks and their connections both inside and outside the country. This analysis shows a strong process of internationalization of local scientific production during the last decade, as well as a shift in research topics from publications focused mainly on health and environmental issues to research with a strong component on data and systems analysis. In a second level of analysis, we explore the relationship between these transformations in techno-scientific production and a postgraduate scholarship policy program which has sponsored Ecuadorians to study abroad over the past two decades. This analysis shows a significant correlation between the number of international scholarships granted and the number of indexed publications. The paper concludes that local transformations in techno-scientific networksarehighlycorrelatedwiththeinternationalizationprocessdrivenbythispostgraduate scholarship program and in general by international scientific research training.

Published
2021

22. Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Author

Brenner, A., Belli, A., Chaudhri, R., Coats, T., Frimley, L., Jamaluddin, S. F., Jooma, R., Mansukhani, R., Sandercock, P., Shakur-Still, H., Shokunbi, T., Roberts, I., Aeron-Thomas, A., Chaudary, M. A., Jamaluddin, S. F. B., Javaid, K., Kayani, A., Leech, C., Mahmood, K., Noor, J. M., Mejia-Mantilla, J., Moss, P., Pott, J., Vallecilla, L., Hartzenberg, H. B., Joshipura, M., Perel, P., Clarke, M. J., Ohaegbulam, S. C., Rodgers, A., Brady, T., Dewan, Y., Edwards, P., Komolafe, E. O., Arribas, M., Austin, E., Balogun, E., Barneston, L., Barrow, C., Beaumont, D., Benyahia, M., Brooks, I., Cargill, M., Carrington, L., Cook, L., Cornu-Hewitt, B., Geer, A., Gilbert, D., Gilliam, C., Gil-Onandia, J., Hetherington, D., Howe, C., Hughes, C., I'Anson, D., Jackson, R., Joshi, M., Kansagra, S., Kawahara, T., Ker, K., Kostrov, S., Mahmood, A., Miah, H., Ndungu, B., Needham, K., Okusi, C., Outtandy, A., Pardinaz-Solis, R., Pearson, D., Pepple, T., Pisani, C., Prieto-Merino, D., Prowse, D., Quashi, N., Quinn, A., Ramos, M., Reid, M., Roukas, C., Scrapa, G., Squires, C., Tanner, J., Thayne, A., Vidaurre, L., Woods, E., Fawole, B., Adetayo, O., Okunade, O., Gogichaishvili, T., de los Angeles Munoz-Sanchez, M., Olldashi, F., Krishnan, S., Djientcheu, V., Castellanos, J. L., Rasulo, F., Hama, Q., Mulla, Y., Florian, I. S., Tobar, J., Khamis, H., Deasy, C., Wellsh, B., Williams-Johnson, J., Chandra, S., Mutiso, V., Butt, R., Nasir, M. H., Ahmad, S., Aslam, F., Ishaque, K., Usmani, F., Rizvi, S., Ali, F., Sajjad, O., Zunair, A., Rehman, L., Rizvi, R., Javeed, F., Ahmed, S., Abbas, A., Afzal, A., Mikdad, A., Bashir, A., Chaudary, A., Salahuddin, T., Ahemed, B., Aziz, A., Ashraf, N., Hussain, S., Ahmad, U., Asif, M., Adil, M., Rauf, A., Khan, R., Ahmad, B., Afzal, U., Raza, H., Ain, Q., Yaqoob, S., Waseem, Q., Nishat, M., Semvel, S., Iqbal, J., Majeed, S., Zulfiqar, S., Iqbal, M., Majeed, N., Ahmed, M., Akhtar, N., Malik, M., Shehzad, Y., Yousaf, M., Wahid, A., Samad, A., Shah, S., Ali, M., Zeb, J., Khan, A. S., Irfan, A., Sharif, S., Memon, R., Bloom, B., Harris, T., Skene, I., Bellhouse, G., Boulton, O., Ward, G., Jarvis, C., Swann, C., Ratnam, S., Carrera, R., Yakoub, K., Davies, D., Fellows, E., Jarman, H., Rounding, S., Johnson, E., Loughran, C., Lecky, F., Clayton, K., Michael, A., Coumbarides, A., Kendall, J., Faulkner, B., Worner, R., Gendall, E., Hopkins, P., Riozzi, P., Cotton, H., Astin-Chamberlain, R., Wilson, M., Bodnar, J., Williams, R., Rigoni, A., Sattout, A., Fletcher, J., Edge, C., Maryanji, N., Boyle, A., Hardwick, S., Nichols, E., Hayhurst, C., Coffey, F., Gough, C., Miller, P., Ryan, L., Darwent, M., Espinosa, A., Beer, S., Norton, J., Maguire, H., Finney, K., Kehoe, A., Squire, R., Jeffery, A., Vorwerk, C., Foord, D., Wilkinson, E., Kuhrt, A., Ramlakhan, S., Reid, S., Curran, A., Mcmullan, S., Hassan, T., Nuttall, S., Haig, S., Al-Nahhas, S., Bulters, D., Zolnourian, A., Ribbons, T., Mew, I., de Weymarn, T., Hughes, V., Mcvicar, J., Mckiernan, C., Keating, L., Reschreiter, H., Wright, J., Chan, L., Kataria, H., Ireland, A., Body, R., Corfield, A., Francis, S., Townend, W., Gagg, J., Wilson, S., Cottingham, R., Tucker, S., Sutherland, F., Mitchell, L., Parker, L., Afolabi, O., Hunter, F., Jadav, M., Adeboye, K., Grocutt, M., May, G., Watson, D., Wootten, A., Robertshaw, S., Dorrian, S., Perry, R., Choi, H., Mcgroarty, C., Shone, P., Maritz, D., Jamaluddin, S., Noor, J., Rosli, N., Xian, L. L. S., De Jun, Y., Mohamed, F., Song, C. H., Hawari, A., Chin, L. Y., Hussein, H. M., Lotfi, M., Hamid, H., Udin, N., Lian, P., Choo, S., Wong, K., Gani, F., Jusoh, M., Rajakumar, D., Yang, C. B., Dzulkiflee, N. S. B., W. C., Ky, Azman, M. A. B. M., Osman, A. B., Ahmad, A. H., Ismail, R., Lai, S. Q., Mohidin, M. A. B., Deraman, N. B., Selamat, S. B., Abidin, I., Halim, N., Bakar, Z., Ismail, Z. M., Hisham, B., Kamal, R., Effendy, Z., Ismail, M., Azleen, N., Seng, L. Y., Baharuddin, K. A., Kandasamy, R., Kamalludin, A., Asmee, S., Fadzil, M., Basitz, A., Abdullah, N., Ingorokva, G., Ingorokva, S., Agdgomelashvili, I., Mumladze, K., Maisuradze, I., Kugusheva, I., Shalamberidze, B., Tomadze, G., Fernandez-Ortega, J., Seara-Valero, R., Ibanez-Botella, G., Garcia-Martinez, V., Martul, M. G., Ramos, S. F., Preciado, G. L., Garcia-Alfaro, C., Munoz-Sanchez, A., Bellido-Alba, R., Corcobado, C., Bueno, A., Ambros, A., Jimenez, J. T., Ramirez, J. R., Martin, J., Rodriguez, L. I., Fontanals, J., Jimenez-Moragas, J. M., Berbegal, J. P., Oluwole, O., Mahmud, R., Ukwu, N., Bankole, F., Oseni, A., Adebayo, B., Malomo, A., Tiamiyu, L., Adekanmbi, A., Thanni, L., Olubodun, A., Ojeblenu, F., Uwaezuoke, M., Komolafe, E., Owagbemi, O., Ishola, F., Durodola, A., Udoffa, U., James, A., Tella, A., Dongo, A., Ekpemiro, U., Anyanwu, S., Aigoro, N., Mezue, W., Shilong, D., Azeez, A., Babalola, O., Ibrahim, M., Obande, J., Franco, A. C., Salazar, E. V., Londono, S. B., Cardona, V. M., Morales, C., Naranjo, S., Agudelo, J., Carvajal, S., Fajardo-Gaviria, Y., Roka, Y., Ghising, U., Roka, N., Shrestha, M., Devkota, U., Vaidya, B., Nepal, P., Thapa, A., Kc, B., Shrestha, A., Jha, R., Shrestha, P., Hodaj, I., Spaho, E., Selaj, A., Bendo, N., Shoko, T., Endo, H., Senda, A., Hagihara, Y., Fuse, T., Masunaga, N., Otomo, Y., Egashira, R., Ohnuki, T., Almazmi, A., Saha, S., Suvarov, A., Aung, T. L., Tun, K. M., Khaing, T. T., Maw, T., Ndome, O., Moumi, M., Mbida, A., Fondop, J., Sebastien, M., Azim, A., Adil, J., Amiry, Z., Loria-Castellanos, J., Rubio, N. G., Leon, P. O., Estrada, F., de Oca-Garcia, E. M., Sanchez, H., Soria, A., Bonucci, P., Franchi, F., Girardini, A., Hameed, H., Basim, M., Stock, S., Hourt, E., Ilunga, A., Mulenga, J., Ples, H., Danil, A., Gorgan, M., Florian, I., Vlahovic, D., French, J., East, J., Kurniawan, A., and Kiboi, J.

Subjects
medicine.medical_specialty, Tranexamic acid, Traumatic brain injury, Epidemiology, Critical Care and Intensive Care Medicine, Placebo, CRASH-3 trial, Neuroprotection, Intracranial haemorrhage, law.invention, Emergence care, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Medicine, Humans, 030212 general & internal medicine, Randomised controlled trial, business.industry, Multiple Trauma, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Protective Factors, medicine.disease, Polytrauma, Antifibrinolytic Agents, 3. Good health, Neuroprotective Agents, Relative risk, Brain Injuries, business, medicine.drug
Abstract

Background The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, we examined the timing of its effect on death. Methods The CRASH-3 trial randomised 9202 patients within 3 h of injury with a GCS score ≤ 12 or intracranial bleeding on CT scan and no significant extracranial bleeding to receive TXA or placebo. We conducted an exploratory analysis of the effects of TXA on all-cause mortality within 24 h of injury and within 28 days, excluding patients with a GCS score of 3 or bilateral unreactive pupils, stratified by severity and country income. We pool data from the CRASH-2 and CRASH-3 trials in a one-step fixed effects individual patient data meta-analysis. Results There were 7637 patients for analysis after excluding patients with a GCS score of 3 or bilateral unreactive pupils. Of 1112 deaths, 23.3% were within 24 h of injury (early deaths). The risk of early death was reduced with TXA (112 (2.9%) TXA group vs 147 (3.9%) placebo group; risk ratio [RR] RR 0.74, 95% CI 0.58–0.94). There was no evidence of heterogeneity by severity (p = 0.64) or country income (p = 0.68). The risk of death beyond 24 h of injury was similar in the TXA and placebo groups (432 (11.5%) TXA group vs 421 (11.7%) placebo group; RR 0.98, 95% CI 0.69–1.12). The risk of death at 28 days was 14.0% in the TXA group versus 15.1% in the placebo group (544 vs 568 events; RR 0.93, 95% CI 0.83–1.03). When the CRASH-2 and CRASH-3 trial data were pooled, TXA reduced early death (RR 0.78, 95% CI 0.70–0.87) and death within 28 days (RR 0.88, 95% CI 0.82–0.94). Conclusions Tranexamic acid reduces early deaths in non-moribund TBI patients regardless of TBI severity or country income. The effect of tranexamic acid in patients with isolated TBI is similar to that in polytrauma. Treatment is safe and even severely injured patients appear to benefit when treated soon after injury. Trial registration ISRCTN15088122, registered on 19 July 2011; NCT01402882, registered on 26 July 2011.

Published
2020

24. Targeted disease prophylaxis in European fish farming (TargetFish): P-296

Author

Wiegertjes, G., Lorenzen, G., Secombes, C., Collet, B., Fischer, U., Tafalla, C., Parra, D., Scapigliati, G., Boudinot, P., Evensen, Ø., Adams, A., Toffan, A., Buchmann, K., Vesely, T., David, L., Mulero, V., Smith, P., Aspehaug, V., Engell-Sørensen, K., Sober, J., Wallis, T., Rød, T., Flores, M., March, J., Stratmann, A., Christofilogiannis, P., Tobar, J., Henriksen, N. H., Sigholt, T., and de las Heras, A.

Published
2013
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26. Healthcare-associated infections (HAIs) in patients with urinary catheter hospitalized in urology: Analysis of risk factors, microbiological characteristics and the efficacy of preventive measures

Author

Medina-Polo, J., primary, González-Padilla, D.A., additional, García-Rojo, E., additional, González-Díaz, A., additional, Abad-López, P., additional, Santos-Pérez De La Blanca, R., additional, Hernández-Arroyo, M., additional, Peña-Vallejo, H., additional, Téigell-Tobar, J., additional, Calzas-Montalvo, C., additional, Caro-González, M.P., additional, Gil-Moradillo, J., additional, Miranda-Utrera, N., additional, Rodríguez-Antolín, A., additional, and Tejido-Sánchez, Á., additional

Published
2020
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32. A1105 - Transplant renal artery stenosis: Study of incidence using doppler ultrasound, risk factors and analysis effect in graft outcomes

Author

Calzas Montalvo, C., Medina Polo, J., Miranda Utrera, N.R., Caro González, M.P., Santos Perez De La Blanca, R., Hernandez Arroyo, M., Peña Vallejo, E., Teigell Tobar, J., Juste Álvarez, S., De La Calle Moreno, A., Rodriguez Antolín, A., Duarte Ojeda, J.M., Pamplona Casamayor, M., Tejido Sánchez, Á., García González, L., Arrébola Pajares, A., and Rodriguez De La Calle, J.

Published
2022
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34. Outcomes of an observational protocol to prevent healthcare-associated infections (HAIs) in a urology ward

Author

Medina-Polo, J., primary, Justo-Quintas, J., additional, Gil-Moradillo, J., additional, García-Rojo, E., additional, González-Padilla, D.A., additional, Abad-López, P., additional, González-Díaz, A., additional, Santos-De La Blanca, R., additional, Hernández-Arroyo, M., additional, Peña-Vallejo, H., additional, Teigell-Tobar, J., additional, López-Medrano, F., additional, and Tejido-Sánchez, Á., additional

Published
2019
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36. TargetFish - Targeted disease prophylaxis in European fish farming

Author

Wiegertjes, G. F., Lorenzen, N., Secombes, C. J., Collet, B., Fischer, U., Tafalla, C., Parra, D., Scapigliati, G., Boudinot, P., Evensen, O., Adams, A., Toffan, A., Buchmann, K., Vesely, T., Lior David, Mulero, V., Smith, P., Aspehaug, V., Engell-Sorensen, K., Sober, J., Wallis, T., Rod, T., Flores, M., Stratmann, A., Christofilogiannis, P., Tobar, J., Henriksen, N., Sigholt, T., Las Heras, A., Wageningen University and Research Centre (WUR), Aarhus University [Aarhus], University of Aberdeen, Marine Scotland, Friedrich-Loeffler-Institut (FLI), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA), Universitat Autònoma de Barcelona (UAB), Tuscia University, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Norwegian School of Veterinary Science, University of Stirling, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), University of Copenhagen = Københavns Universitet (KU), Veterinary Research Institute, The Hebrew University of Jerusalem (HUJ), Universidad de Murcia, Tethys Aquaculture Limited, Partenaires INRAE, PatoGen Analyses AS, Ridgeway Biologicals Limited, Rossi A/S, Ingeniatrics Tecnologias S.L., W42 Industrial Biotechnology GmbH, Centro Veterinario y Agricola, Danish Trout Association, and BIOMAR S.A.

Subjects
Cell Biology and Immunology, [SDV]Life Sciences [q-bio], WIAS, Life Science, Celbiologie en Immunologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

37. TargetFish - Targeted disease prophylaxis in European fish farming

Author

Wiegertjes, G.F., Lorenzen, N., Secombes, C.J., Collet, B., Fischer, U., Tafalla, C., Parra, D., Scapigliati, G., Boudinot, P., Evensen, Ø., Adams, A., Toffan, A., Buchmann, K., Vesely, T., David, L., Mulero, V., Smith, P., Aspehaug, V., Engell-Sørensen, K., Sober, J., Wallis, T., Rød, T., Flores, M., Stratmann, A., Christofilogiannis, P., Tobar, J., Henriksen, N., Sigholt, T., De Las Heras, A., Wiegertjes, G.F., Lorenzen, N., Secombes, C.J., Collet, B., Fischer, U., Tafalla, C., Parra, D., Scapigliati, G., Boudinot, P., Evensen, Ø., Adams, A., Toffan, A., Buchmann, K., Vesely, T., David, L., Mulero, V., Smith, P., Aspehaug, V., Engell-Sørensen, K., Sober, J., Wallis, T., Rød, T., Flores, M., Stratmann, A., Christofilogiannis, P., Tobar, J., Henriksen, N., Sigholt, T., and De Las Heras, A.

Published
2016

39. Latin American Dialysis and Renal Transplant Registry: 2008 report (data 2006)

Author

Cusumano, A. M., Bedat, M. G., García-García, G., Fernandez, S. M., Jocemir Ronaldo Lugon, Badal, H. P., Miranda, S. E., Gómez, R., Calderón, M. C., López, M. A., Tobar, J. M., Merino, R. L., Polo, J. S., Meda, R. L., Acosta, B. F., Ferrari, R. A., Escudero, E., López, A. S., Castro, E. M., Milanés, C. L., Carlini, R., and Garcia, V. D.

Subjects
Latin America, Renal Dialysis, Humans, Registries, Kidney Transplantation
Abstract

Between 1991 and 2006, the Latin American Dialysis and Renal Transplantation Registry collected data from 20 countries (Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Cuba, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Puerto Rico, Dominican Republic, Venezuela and Uruguay). Access to RRT was universal in Argentina, Brazil, Chile, Cuba, Puerto Rico, Venezuela and Uruguay, all countries belonging to the medium-high or high income group.Data about patients on renal replacement therapy (RRT) were supplied by national affiliates or the Registry's Coordination Committee. Transplant data were gathered and shared with the Latin American and Caribbean Society of Transplantation.RRT prevalence increased from 162 patients per million population (pmp) in 1991 to 478 pmp in 2005 and 473 pmp in 2006 (59.2% hemodialysis, 20.4% peritoneal dialysis and 20.4% with a functioning kidney allograft). Countries with the highest prevalence were Puerto Rico (1,148.9 pmp), Uruguay (924.5 pmp) and Chile (907.6 pmp). Latin America's (LA) incidence increased from 27.8 pmp in 1992 to 188 pmp in 2006. The LA Kidney transplant rate increased from 3.7 pmp in 1987 to 15,4 pmp in 2006, and 166 combined transplants - kidney and another organ, mainly pancreas - were performed. In the medium-high income group 2006, (Argentina, Brazil, Chile, Costa Rica, Cuba, Mexico, Panama, Uruguay, Venezuela) the prevalence rate was 534.8 pmp vs. 289.5 pmp in the middle-low income group. The transplant rate was 18.4 pmp in the medium-high income group vs. 7 pmp in the middle-low group (p0.01).RRT incidence and prevalence continue to grow steadily. Access to RRT is universal only in some countries included in the medium-high or high income group. It is imperative to accomplish the goal of making RRT available to all who need it.

Published
2010

41. La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas

Author

Kalergis, AM, Fierro, A, Figueroa, C, Gonzalez, P, and Tobar, J

Subjects
T Lymphocytes, Immunity, cellular, Histocompatibility antigens
Abstract

The important role that T lymphocytes play during the immune response against pathogens and tumor cells has encouraged the development of technologies aimed to detect these immune cells in an antigen-specific fashion. Recently, a methodology consisting of the production of soluble ligands that bind the T lymphocyte receptor was developed. Such ligands consist of molecules from the Major Histocompatibility Complex loaded with either pathogen or tumor derived peptides. These molecular complexes are tetramerized to enhance the binding efficiency to the T cell receptor (TCR), which improves the detection sensitivity of antigen specific T lymphocytes. This new technology is currently used successfully during the follow up patients that were vaccinated against certain tumor antigens, to evaluate the expansion of tumor specific T lymphocytes. This methodology is also promising for the detection and specific deletion of autoreactive T lymphocytes as a treatment for autoimmune disorders. In this article we review the molecular components involved in antigen recognition by T lymphocytes, and the potential benefits for Biomedicine that could result from the detection of these cells by soluble specific ligands (Rev Méd Chile 2004; 132: 371-80).

Published
2004

43. Estenosis arterial del injerto renal: evaluación de la incidencia mediante ecografía doppler, factores de riesgo y análisis de las complicaciones que pueden afectar la supervivencia del injerto

Author

Calzas Montalvo, C., Medina-Polo, J., Miranda Utrera, N.R., Juste Álvarez, S., de la Calle Moreno, A., del Prado Caro González, M., Santos Perez de la Blanca, R., Hernández Arroyo, M., Peña Vallejo, E., Teigell Tobar, J., Duarte Ojeda, J.M., Pamplona Casamayor, M., Tejido Sánchez, Á., García González, L., Arrébola Pajares, A., Guerrero González, Á., Rodríguez de la Calle, J., and Rodríguez Antolín, A.

Abstract

La estenosis de la arteria del injerto renal (EAR) es una complicación vascular del trasplante renal cuya incidencia estimada es del 13%, la cual puede causar hipertensión arterial refractaria, disfunción renal y muerte prematura en los receptores de trasplantes.

Published
2023
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45. New splicing mutation of MEN1gene affecting the translocation of menin to the nucleous

Author

Tala, H., Carvajal, C., González, A., Garrido, J., Tobar, J., Solar, A., Campino, C., Arteaga, E., and Fardella, C.

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is a syndrome inherited in an autosomal dominant trait caused by the inactivation of the tumor suppressor gene MEN1. Objective: To communicate a family with a new heterozygous germ line mutation in the intronic region of MEN1gene and to study its influence in the menin expression. Patients and Methods: We studied 5 members of a family with symptomatic hyperparathyroidism (HPT). One of them had also a neuroendocrine pancreatic tumor, and 2 had non-functional multinodular cortical adrenal hyperplasia compatible with the diagnosis of MEN1. After the mutation was identified, HSP92IIrestriction enzyme was used to determine both zygosity and segregation of the mutation. RT-PCR from leukocyte’s isolated mRNA and western blot from pancreatic tumor tissue were performed. In vitrostudies were done in Chinese hamster ovary (CHO) cells transfected with reporter minigenes carrying the coding regions spanning exon (EX)-intron 9 and EX10 with the mutant and the wild type sequences. Results: We identified a heterozygous G-to-T substitution in the intron-EX junction (IVS9-1 G>T) of MEN1gene in the index case and the family members. The mRNA from patient’s leukocytes was larger (934 bp) in comparison to the normal transcript (717 bp). Immunoblot analysis demonstrated that wild type (67 kDa) and two additional mutant proteins (~55 and ~90 kDa) were expressed in the pancreatic tissue. The in vitrostudy showed a 45% nuclear localization of the mutated menin signal and a 95% in the wild type protein. Conclusions: We identified a new intronic heterozygous germ line mutation (IVS9-1G>T) of MEN1gene in a family affected by MEN1 syndrome. This mutation alters the splice acceptor site of intron 9 that promotes an incorrect splicing, generating aberrant proteins without the nuclear localization signals necessary for the normal menin translocation to the nucleus.

Published
2006
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46. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2) a randomised, placebo-controlled trial

Author

Olldashi, F., Kerçi, M., Zhurda, T., Ruçi, K., Banushi, A., Traverso, M. S., Jiménez, J., Balbi, J., Dellera, C., Svampa, S., Quintana, G., Piñero, G., Teves, J., Seppelt, I., Mountain, D., Balogh, Z., Zaman, M., Druwé, P., Rutsaert, R., Mazairac, G., Pascal, F., Yvette, Z., Chancellin, D., Okwen, P., Djokam-Liapoe, J., Jangwa, E., Mbuagbaw, L., Fointama, N., Pascal, N., Baillie, F., Jiang, J. -Y, Gao, G. -Y, Bao, Y. -H, Morales, C., Sierra, J., Naranjo, S., Correa, C., Gómez, C., Herrera, J., Caicedo, L., Rojas, A., Pastas, H., Miranda, H., Constaín, A., Perdomo, M., Muñoz, D., Duarte, Á, Vásquez, E., Ortiz, C., Ayala, B., Delgado, H., Benavides, G., Rosero, L., Mejía-Mantilla, J., Varela, A., Calle, M., Castillo, J., García, A., Ciro, J., Villa, C., Panesso, R., Flórez, L., Gallego, A., Puentes-Manosalva, F., Medina, L., Márquez, K., Romero, A. R., Hernández, R., Martínez, J., Gualteros, W., Urbina, Z., Velandia, J., Benítez, F., Trochez, A., Villarreal, A., Pabón, P., López, H., Quintero, L., Rubiano, A., Tamayo, J., Piñera, M., Navarro, Z., Rondón, D., Bujan, B., Palacios, L., Martínez, D., Hernández, Y., Fernández, Y., Casola, E., Delgado, R., Herrera, C., Arbolaéz, M., Domínguez, M., Iraola, M., Rojas, O., Enseñat, A., Pastrana, I., Rodríguez, D., La Campa, S. 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48. A0138 - Antibiotic prophylaxis before urodynamic studies: Are antibiotics required to decrease infections and for which patients would be prophylaxis the most beneficial?

Author

Juste Alvarez, S., Medina-Polo, J., Arrebola Pajares, A., Teigell Tobar, J., Peña Vallejo, E., Calzas Montalvo, C., Caro González, P., De La Calle Moreno, A., García-Rayo Encina, C., González Ginel, I., and Rodríguez Antolín, A.

Subjects
*ANTIBIOTIC prophylaxis, *ANTIBIOTICS, *PREVENTIVE medicine, *INFECTION
Published
2023
Full Text
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