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1. Long-term myocardial effects of noninvasive ventilation in patients with obesity hypoventilation syndrome

Author: Paranicova, I., Bodnarova, S., Trojova, I., Hertelyova, Z., Gulasova, Z., Cimbolakova, I., Genzor, S., Joppa, P., Tkacova, R., and Pobeha, P.
Published: 2024
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2. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author: Steiropoulos, P., Verbraecken, J., Petiet, E., Trakada, G., Montserrat, J.M., Fietze, I., Penzel, T., Ondrej, L., Rodenstein, D., Masa, J.F., Bouloukaki, I., Schiza, S., Kent, B., McNicholas, W.T., Ryan, S., Riha, R.L., Kvamme, J.A., Hein, H., Schulz, R., Grote, L., Hedner, J., Zou, D., Pépin, J.L., Levy, P., Bailly, S., Lavie, L., Lavie, P., Basoglu, O.K., Tasbakan, M.S., Varoneckas, G., Joppa, P., Tkacova, R., Staats, R., Barbé, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Bonsignore, M.R., Marrone, O., Petitjean, M., Roisman, G., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Pataka, A., Anttalainen, U., Saaresranta, T., Plywaczewski, R., Sliwinski, P., Bielicki, P., Gunduz, Canan, Basoglu, Ozen K., Kvamme, John Arthur, Verbraecken, Johan, Anttalainen, Ulla, Marrone, Oreste, Steiropoulos, Paschalis, Roisman, Gabriel, Joppa, Pavol, Hein, Holger, Trakada, Georgia, Hedner, Jan, and Grote, Ludger
Published: 2020
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3. Inhaled therapies in patients with moderate COPD in clinical practice: current thinking

Author: Ariel A, Altraja A, Belevskiy A, Boros PW, Danila E, Fležar M, Koblizek V, Fridlender ZG, Kostov K, Krams A, Milenkovic B, Somfay A, Tkacova R, Tudoric N, Ulmeanu R, and Valipour A
Subjects: dual bronchodilation, inhaled corticosteroid, LAMA, LABA, tiotropium, anticholinergic, Diseases of the respiratory system, RC705-779
Abstract: Amnon Ariel,1 Alan Altraja,2,3 Andrey Belevskiy,4 Piotr W Boros,5 Edvardas Danila,6 Matjaz Fležar,7 Vladimir Koblizek,8 Zvi G Fridlender,9 Kosta Kostov,10 Alvils Krams,11 Branislava Milenkovic,12 Attila Somfay,13 Ruzena Tkacova,14 Neven Tudoric,15 Ruxandra Ulmeanu,16 Arschang Valipour17 1Emek Medical Center, Clalit Healthcare Services, Afula, Israel; 2Department of Pulmonary Medicine, University of Tartu, 3Lung Clinic, Tartu University Hospital, Tartu, Estonia; 4Department of Pulmonology, Russian National Research Medical University, Moscow, Russia; 5Lung Pathophysiology Department, National TB and Lung Diseases Research Institute, Warsaw, Poland; 6Clinic of Infectious Chest Diseases, Dermatovenereology, and Allergology, Vilnius University, Centre of Pulmonology and Allergology, Vilnius University Hospital, Vilnius, Lithuania; 7University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia; 8Department of Pneumology, University Hospital, Hradec Králové, Czech Republic; 9Institute of Pulmonary Medicine, Hadassah Medical Center, Jerusalem, Israel; 10Clinic of Pulmonary Diseases, Military Medical Academy, Sofia, Bulgaria; 11Medical Faculty of Latvian University, Riga East University Hospital, Riga, Latvia; 12Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 13Department of Pulmonology, University of Szeged, Deszk, Hungary; 14Department of Respiratory Medicine and Tuberculosis, Faculty of Medicine, PJ Safarik University, Košice, Slovakia; 15School of Medicine, Dubrava University Hospital, Zagreb, Croatia; 16Marius Nasta Institute of Pneumology, Bucharest, Romania; 17Department of Respiratory and Critical Care Medicine, Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria Abstract: COPD is a complex, heterogeneous condition. Even in the early clinical stages, COPD carries a significant burden, with breathlessness frequently leading to a reduction in exercise capacity and changes that correlate with long-term patient outcomes and mortality. Implementation of an effective management strategy is required to reduce symptoms, preserve lung function, quality of life, and exercise capacity, and prevent exacerbations. However, current clinical practice frequently differs from published guidelines on the management of COPD. This review focuses on the current scientific evidence and expert opinion on the management of moderate COPD: the symptoms arising from moderate airflow obstruction and the burden these symptoms impose, how physical activity can improve disease outcomes, the benefits of dual bronchodilation in COPD, and the limited evidence for the benefits of inhaled corticosteroids in this disease. We emphasize the importance of maximizing bronchodilation in COPD with inhaled dual-bronchodilator treatment, enhancing patient-related outcomes, and enabling the withdrawal of inhaled corticosteroids in COPD in well-defined patient groups. Keywords: dual bronchodilation, inhaled corticosteroid, LAMA, LABA, tiotropium, anticholinergic
Published: 2017

4. POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe

Author: Zbozinkova Z, Barczyk A, Tkacova R, Valipour A, Tudoric N, Zykov K, Somfay A, Miravitlles M, and Koblizek V
Subjects: COPD, phenotypes, Central Europe, Eastern Europe, study, GOLD, co-morbidity, Diseases of the respiratory system, RC705-779
Abstract: Zuzana Zbozinkova,1 Adam Barczyk,2 Ruzena Tkacova,3 Arschang Valipour,4 Neven Tudoric,5 Kirill Zykov,6 Attila Somfay,7 Marc Miravitlles,8 Vladimir Koblizek91Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 2Department of Pneumology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland; 3Department of Respiratory Medicine, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; 4Department of Respiratory and Critical Care Medicine, Ludwig-Boltzmann-Institute for COPD and Respiratory Epidemiology, Otto-Wagner-Spital, Wien, Austria; 5School of Medicine Zagreb, University Hospital Dubrava, Zagreb, Croatia; 6Laboratory of Pulmonology, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia; 7Department of Pulmonology, University of Szeged, Deszk, Hungary; 8Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain; 9Department of Pneumology, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech RepublicIntroduction: Chronic obstructive pulmonary disease (COPD) constitutes a major health challenge in Central and Eastern European (CEE) countries. However, clinical phenotypes, symptom load, and treatment habits of patients with COPD in CEE countries remain largely unknown. This paper provides a rationale for phenotyping COPD and describes the methodology of a large study in CEE.Methods/design: The POPE study is an international, multicenter, observational cross-sectional survey of patients with COPD in CEE. Participation in the study is offered to all consecutive outpatients with stable COPD in 84 centers across the CEE region if they fulfill the following criteria: age >40 years, smoking history ≥10 pack-years, a confirmed diagnosis of COPD with postbronchodilator FEV1/FVC ,0.7, and absence of COPD exacerbation ≥4 weeks. Medical history, risk factors for COPD, comorbidities, lung function parameters, symptoms, and pharmaceutical and nonpharmaceutical treatment are recorded. The POPE project is registered in ClinicalTrials.gov with the identifier NCT02119494.Outcomes: The primary aim of the POPE study was to phenotype patients with COPD in a real-life setting within CEE countries using predefined classifications. Secondary aims of the study included analysis of differences in symptoms, and diagnostic and therapeutic behavior in participating CEE countries.Conclusion: There is increasing acceptance toward a phenotype-driven therapeutic approach in COPD. The POPE study may contribute to reveal important information regarding phenotypes and therapy in real-life CEE.Keywords: COPD, phenotypes, Central Europe, Eastern Europe, study, GOLD, comorbidity
Published: 2016

5. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author: Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Riha R. L., Kotoulas S. -. C., Pataka A., Kvamme J. A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B. D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Parati G., Penzel T., Pepin J. L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S. E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., Zielinski J., Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Riha R. L., Kotoulas S. -. C., Pataka A., Kvamme J. A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B. D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Parati G., Penzel T., Pepin J. L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S. E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., and Zielinski J.
Abstract: Background: The impact of removing the upper airway lymphoid tissue and in particular, tonsillectomy, in adults with OSA has not been demonstrated in large populations. Aims: To compare the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between patients with OSA who had undergone previous tonsillectomy and those who had not. Methods: The 19,711 participants in this study came from the European sleep apnea database (ESADA) which comprises data from unselected adult patients aged 18–80 years with a history of symptoms suggestive of OSA referred to sleep centers throughout Europe. Results: There were no differences between the two groups in terms of sex ratio and age (146 patients with previous tonsillectomy vs. 19565 patients without). Patients who had undergone tonsillectomy had a lower body mass index (29.3 ± 5.2 kg/m2 vs 32.2 ± 6.6 kg/m2, p < 0.001), lower subjective sleep latency (17.1 ± 17.8 min vs 25.5 ± 30.4 min, p = 0.001), lower ODI (15.7 ± 18.3 events/hour vs 30.7 ± 26.1 events/hour, p < 0.001), and SpO2<90% time during sleep (21.8 ± 47.5 min vs 52.6 ± 80.8 min, p < 0.001). OSA patients with tonsillectomy had a lower prevalence of Type II diabetes mellitus (p = 0.001), hypertension (p < 0.001) and a higher prevalence of hyperlipidemia (p < 0.001) and were less likely to be commenced on CPAP (p < 0.001). Conclusion: In a large population of almost 20,000 OSA patients from across Europe, patients who had undergone tonsillectomy presented with less severe OSA at time of diagnosis, and had a lower prevalence of Type II diabetes mellitus and cardiovascular co-morbidities.
Published: 2021

6. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author: Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., Bielicki P., Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., and Bielicki P.
Abstract: Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies.
Published: 2020

7. Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

Author: Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J. -L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O. K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J. A., Levy P., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Pataka A., Penzel T., Petiet E., Pepin J. L., Plywaczewski R., Pretl M., Riha R. L., Ryan S., Saaresranta T., Schulz R., Tasbakan M. S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Verbraecken J., Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J. -L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O. K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J. A., Levy P., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Pataka A., Penzel T., Petiet E., Pepin J. L., Plywaczewski R., Pretl M., Riha R. L., Ryan S., Saaresranta T., Schulz R., Tasbakan M. S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., and Verbraecken J.
Abstract: Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort. Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency). Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP. Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.
Published: 2020

8. Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

Author: Lombardi C, Parati G, Soranna D, Zambon A, Sliwinski P, Roisman G, Pepin JL, Schiza S, Riha R, Joppa P, Fietze I, Hedner J, Grote L, European Sleep Apnoea Database (ESADA) Collaborators (ESADA Collaborators: Anttalainen U, Barbé F, Bonsignore MR, Basoglu OK, Bielicki P, Dogas Z, Dorkova Z, Escourrou P, Hein H, Kvamme JA, Levy P, Marrone O, Masa JF, McNicholas WT, Montserrat JM, Pataka A, Penzel T, Petiet E, Pépin JL, Plywaczewski R, Pretl M, Riha RL, Ryan S, Saaresranta T, Schulz R, Tasbakan MS, Tkacova R, Staats R, Steiropoulos P, Varoneckas G, Verbraecken J), Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J.-L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M.R., Basoglu O.K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J.A., Levy P., Marrone O., Masa J.F., McNicholas W.T., Montserrat J.M., Pataka A., Penzel T., Petiet E., Pepin J.L., Plywaczewski R., Pretl M., Riha R.L., Ryan S., Saaresranta T., Schulz R., Tasbakan M.S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Verbraecken J., Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Institute of Tuberculosis and Lung Diseases [Warsaw, Poland] (ITLD), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), University of Crete [Heraklion] (UOC), Royal Infirmary of Edinburgh, Univerzitnej nemocnice L. Pasteura Košice [Košice, Slovakia]. (UNLPK), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Gothenburg (GU), Sahlgrenska Academy at University of Gothenburg [Göteborg], European Sleep Apnoea Database (ESADA) Collaborators: Anttalainen U, Barbé F, Bonsignore Mr, Basoglu Ok, Bielicki P, Dogas Z, Dorkova Z, Escourrou P, Fietze I, Grote L, Hedner J, Hein H, Joppa P, Kvamme Ja, Levy P, Lombardi C, Marrone O, Masa Jf, McNicholas Wt, Montserrat Jm, Parati G, Pataka A, Penzel T, Petiet E, Pépin Jl, Plywaczewski R, Pretl M, Riha Rl, Roisman G, Ryan S, Saaresranta T, Schiza S, Schulz R, Sliwinski P, Pepin Jl, Tasbakan Ms, Tkacova R, Staats R, Steiropoulos P, Varoneckas G, Verbraecken J, SALAS, Danielle, Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, and Verbraecken, J
Subjects: Male, Pulmonary and Respiratory Medicine, Multivariate statistics, medicine.medical_specialty, obstructive sleep apnoea, Systole, Movement, [SDV]Life Sciences [q-bio], Blood Pressure, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Cohort Studies, 03 medical and health sciences, Sleep Apnea Syndromes, 0302 clinical medicine, Diastole, cardiovascular disease, Diabetes mellitus, Internal medicine, medicine, Humans, 030212 general & internal medicine, sleep disorder, Sleep disorder, Univariate analysis, business.industry, Confounding, Extremities, clinical epidemiology, Middle Aged, medicine.disease, Sleep in non-human animals, Europe, [SDV] Life Sciences [q-bio], Cross-Sectional Studies, Blood pressure, Databases as Topic, 030228 respiratory system, Cohort, Female, Sleep, business
Abstract: International audience; Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort.Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2 ) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency).Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP.Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.
Published: 2020

9. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

Author: Anttalainen, Ulla, Grote, L., Fietze, I., Riha, R. L., Ryan, S., Staats, R., Hedner, J., Saaresranta, T., Anttalainen, U., Barbe, F., Bonsignore, M. R., Basoglu, O., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I, Esquinas, C., Hayes, L., Joppa, P., Kurki, S., Kvamme, J. A., Tamisier, R., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pepin, J. L., Pretl, M., Roisman, G., Schiza, S. E., Schulz, R., Sliwinski, P., Steiropoulos, P., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vrints, H., Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R.L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M.R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J.A., Tamisier R., Lombardi C., Marrone O., McNicholas W.T., Montserrat J.M., Parati G., Pataka A., Penzel T., Pepin J.L., Pretl M., Roisman G., Schiza S.E., Schulz R., Sliwinski P., Tasbakan M.S., Tkacova R., Varoneckas G., Verbraecken J., Vrints H., Ege Üniversitesi, and ESADA Study Collaborators
Subjects: Adult, Male, medicine.medical_specialty, Insomnia, Neurology, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Nocturnal, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Sleep Initiation and Maintenance Disorders, Internal medicine, mental disorders, Prevalence, Humans, Medicine, Hypoxia, Sleep Apnea, Obstructive, business.industry, Sleep Breathing Physiology and Disorders • Original Article, Sleep apnea, Middle Aged, Cardiovascular disease, Phenotype, Hypoxia (medical), medicine.disease, Circadian Rhythm, nervous system diseases, Europe, 030228 respiratory system, Otorhinolaryngology, Cardiovascular Diseases, Cohort, Female, Human medicine, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: WOS: 000482433800011, PubMed ID: 30467691, Purpose The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m(2)), and ODI (15 vs. 32/h). Conclusion High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms., European Union COST action B26; European Respiratory Society (ERS); ResMed Inc.; Philips Respironics Inc., The ESADA network has received support from the European Union COST action B26. The European Respiratory Society (ERS) supports the ESADA for the second period as a Clinical Research Collaboration (CRC) (2015-2017 and 2018-2020). Unrestricted seeding grants from ResMed Inc. and Philips Respironics Inc. for establishment of the organization and the database are gratefully acknowledged.
Published: 2018

10. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database

Author: Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, Dieltjens M., Verbraecken J. A., Hedner J., Vanderveken O. M., Steiropoulos P., Kvamme J. A., Saaresranta T., Tkacova R., Marrone O., Dogas Z., Schiza S., Grote L., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Hein H., Basoglu O. K., Tasbakan M. S., Varoneckas G., Joppa P., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Escourrou P., Roisman G., Pretl M., Vitols A., Galic T., Pataka A., Anttalainen U., Sliwinski P., Plywaczewski R., Bielicki P., Zielinski J., Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, Dieltjens M., Verbraecken J. A., Hedner J., Vanderveken O. M., Steiropoulos P., Kvamme J. A., Saaresranta T., Tkacova R., Marrone O., Dogas Z., Schiza S., Grote L., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Hein H., Basoglu O. K., Tasbakan M. S., Varoneckas G., Joppa P., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Escourrou P., Roisman G., Pretl M., Vitols A., Galic T., Pataka A., Anttalainen U., Sliwinski P., Plywaczewski R., Bielicki P., and Zielinski J.
Abstract: Objective/Background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA). Patients/Methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Anthropometrics, comorbidities, apnea severity obtained by polygraphy or polysomnography, and daytime sleepiness [Epworth Sleepiness Scale (ESS)] were assessed. The CGI 7-point scale was completed at the end of the diagnostic process (CGI-severity, ie, CGI-S) and, in a subpopulation, at treatment follow-up (CGI-Improvement). Results: CGI-S was rated mild to moderate in 44% of patients. CGI rating at any given apnea intensity was worse in women than in men (p < 0.01). Patients undergoing polygraphy (n = 5075) were more frequently rated as severely ill compared to those studied with polysomnography (19.0% vs 13.0%, p < 0.001). In patients aged ≤65 years, CGI scoring was generally better than in the elderly despite a similar degree of OSA (eg, ‘normal, not ill’ 24.2% vs 15.3%, p < 0.01, respectively). Independent predictors of CGI rating included age, BMI, AHI, ESS, cardio-metabolic comorbidities, and diagnosis based on polygraphy. CGI-improvement rating (Beta = −0.406, p < 0.01) was superior to sleep apnea severity or ESS-score (Beta = 0.052 and −0.021, p = 0.154 and 0.538 respectively) at baseline for prediction of good CPAP compliance at follow-up. Conclusions: CGI rating is confounded by gender, age class and the type of sleep diagnostic method. As OSA phenotypes differ, CGI may contribute as a clinical tool to reflect the significance of clinical disease.
Published: 2019

11. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author: Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., and Bielicki P.
Abstract: Background and objective: Obstructive sleep apnoea (OSA) and hyperlipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and prevalence of hyperlipidaemia in patients of the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 11 892 patients (age 51.9 ± 12.5 years, 70% male, body mass index (BMI) 31.3 ± 6.6 kg/m2, mean oxygen desaturation index (ODI) 23.7 ± 25.5 events/h) investigated for OSA. The independent odds ratio (OR) for hyperlipidaemia in relation to measures of OSA (ODI, apnoea-hypopnoea index, mean and lowest oxygen saturation) was determined by means of general linear model analysis with adjustment for important confounders such as age, BMI, comorbidities and study site. Results: Hyperlipidaemia prevalence increased from 15.1% in subjects without OSA to 26.1% in those with severe OSA, P < 0.001. Corresponding numbers in patients with diabetes were 8.5% and 41.5%, P < 0.001. Compared with ODI quartile I, patients in ODI quartiles II-IV had an adjusted OR (95% CI) of 1.33 (1.15–1.55), 1.37 (1.17–1.61) and 1.33 (1.12–1.58) (P < 0.001), respectively, for hyperlipidaemia. Obesity was defined as a significant risk factor for hyperlipidaemia. Subgroups of OSA patients with cardio-metabolic comorbidities demonstrated higher prevalence of HL. In addition, differences in hyperlipidaemia prevalence were reported in European geographical regions with the highest prevalence in Central Europe. Conclusion: Obstructive sleep apnoea, in particular intermittent hypoxia, was independently associated with the prevalence of hyperlipidaemia diagnosis.
Published: 2019

12. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

Author: Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R. L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J. A., Tamisier R., Lombardi C., Marrone O., McNicholas W. T., Montserrat J. M., Parati G., Pataka A., Penzel T., Pepin J. L., Pretl M., Roisman G., Schiza S. E., Schulz R., Sliwinski P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vrints H., Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R. L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J. A., Tamisier R., Lombardi C., Marrone O., McNicholas W. T., Montserrat J. M., Parati G., Pataka A., Penzel T., Pepin J. L., Pretl M., Roisman G., Schiza S. E., Schulz R., Sliwinski P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., and Vrints H.
Abstract: Purpose: The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods: Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results: The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m2), and ODI (15 vs. 32/h). Conclusion: High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms.
Published: 2019

13. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author: Gunduz, C., Basoglu, O. Kacmaz, Hedner, J., Bonsignore, M. R., Hein, H., Staats, R., Bouloukaki, I, Roisman, G., Pataka, A., Sliwinski, P., Ludka, O., Pepin, J. L., Grote, L., Steiropoulos, P., Verbraecken, Johan, Petiet, E., Trakada, G., Montserrat, J. M., Fietze, I, Penzel, T., Ondrej, L., Rodenstein, D., Masa, J. F., Schiza, S., Kent, B., McNicholas, W. T., Ryan, S., Riha, R. L., Kvamme, J. A., Schulz, R., Zou, D., Pepina, J. L., Levy, P., Bailly, S., Lavie, L., Lavie, P., Basoglu, O. K., Tasbakan, M. S., Varoneckas, G., Joppa, P., Tkacova, R., Barbe, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Marrone, O., Petitjean, M., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Anttalainen, U., Saaresranta, T., Plywaczewski, R., Bielicki, P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Tıp Fakültesi, Gunduz C., Basoglu O.K., Hedner J., Bonsignore M.R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J.L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J.M., Fietze I., Penzel T., Rodenstein D., Masa J.F., Schiza S., Kent B., McNicholas W.T., Ryan S., Riha R.L., Kvamme J.A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M.S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., SALAS, Danielle, Biruni University [Istanbul] (BU), Ege university, University of Gothenburg (GU), Sahlgrenska University Hospital [Gothenburg], Università degli studi di Palermo - University of Palermo, CNR-IBIM : National Research Council-Institute of Biomedicine and Molecular Immunology, St. Adolf-Stift Hospital [Reinbek, Germany] (SASH), Hospital de Santa Maria [Lisboa], University of Crete [Heraklion] (UOC), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), General Hospital of Thessaloniki George Papanikolaou, Institute of Tuberculosis and Lung Diseases [Warsaw, Poland] (ITLD), University Hospital Brno, St. Anne’s University Hospital [Brno], Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), European Sleep Apnoea Database collaborators: P Steiropoulos, J Verbraecken, E Petiet, G Trakada, J M Montserrat, I Fietze, T Penzel, D Rodenstein, J F Masa, S Schiza, B Kent, W T McNicholas, S Ryan, R L Riha, J A Kvamme, R Schulz, D Zou, J L Pépin, P Levy, S Bailly, L Lavie, P Lavie, M S Tasbakan, G Varoneckas, P Joppa, R Tkacova, F Barbé, C Lombardi, G Parati, M Drummond, M van Zeller, O Marrone, M Petitjean, M Pretl, A Vitols, Z Dogas, T Galic, U Anttalainen, T Saaresranta, R Plywaczewski, P Bielicki, and European Sleep Apnoea Database Col
Subjects: Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Polysomnography, Hyperlipidemias, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 030204 cardiovascular system & hematology, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Prevalence, Internal Medicine, Humans, Medicine, cholesterol, hyperlipidaemia, hypoxia, obesity, sleep apnoea, Obesity, Sleep Apnea, Obstructive, Database, business.industry, Confounding, Sleep apnea, Odds ratio, Middle Aged, medicine.disease, respiratory tract diseases, [SDV] Life Sciences [q-bio], Europe, Cross-Sectional Studies, 030104 developmental biology, Quartile, Cardiovascular Diseases, Cohort, Female, Human medicine, business, Body mass index, computer
Abstract: Gunduz C, Basoglu OK, Hedner J, et al; onbehalf of the European Sleep Apnoea Databasecollaborators (Biruni University; Ege University;Gothenburg University; Sahlgrenska UniversityHospital; University of Palermo; CNR Institute ofBiomedicine and Molecular Immunology; St. AdolfStift; Hospital de Santa Maria; University of Crete;Antoine-Beclere Hospital; G. PapanikolaouHospital; Institute of Tuberculosis and LungDiseases; University Hospital Brno; St. Ann’sUniversity Hospital; Universite ́ Grenoble Alpes)Hyperlipidaemia prevalence and cholesterolcontrol in obstructive sleep apnoea: Data from theEuropean sleep apnea database (ESADA).J InternMed2019;286: 676–688.Background and objective.Obstructive sleep apnoea(OSA) and hyperlipidaemia are independent riskfactors for cardiovascular disease. This studyinvestigates the association between OSA andprevalence of hyperlipidaemia in patients of theEuropean Sleep Apnea Database (ESADA) cohort.Methods.The cross-sectional analysis included11 892 patients (age 51.9 12.5 years, 70% male,body mass index (BMI) 31.3 6.6 kg/m2, meanoxygen desaturation index (ODI) 23.7 25.5events/h) investigated for OSA. The independentodds ratio (OR) for hyperlipidaemia in relation tomeasures of OSA (ODI, apnoea-hypopnoea index,mean and lowest oxygen saturation) was deter-mined by means of general linear model analysiswith adjustment for important confounders suchas age, BMI, comorbidities and study site.Results.Hyperlipidaemia prevalence increased from15.1% in subjects without OSA to 26.1% in thosewith severe OSA,P
Published: 2019

14. Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Author: Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., Vitols, A., Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gunduz, C, Hender, J, and Lepin, J
Subjects: Male, obesity, Databases, Factual, cholesterol, dyslipidemia, hypoxia, obesity, sleep apnoea, Gastroenterology, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Hypolipidemic Agents, Oxygen saturation (medicine), Sleep Apnea, Obstructive, medicine.diagnostic_test, Sleep apnea, Middle Aged, Europe, Quartile, Cardiovascular Diseases, Cohort, Female, lipids (amino acids, peptides, and proteins), Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, medicine, Humans, Triglycerides, Dyslipidemias, hypoxia, Cholesterol, business.industry, Cholesterol, HDL, dyslipidemia, cholesterol, Cholesterol, LDL, ta3121, medicine.disease, Obesity, nervous system diseases, respiratory tract diseases, Cross-Sectional Studies, 030228 respiratory system, chemistry, Lipid profile, business, sleep apnoea, 030217 neurology & neurosurgery, Dyslipidemia
Abstract: Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results: There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion: OSA severity was independently associated with cholesterol and TG concentrations.
Published: 2018

15. Breathing Pattern Characteristics and Survival Time during Severe Hypoxia in Cats

Author: Tkáčová, R., Tomori, Z., Acker, Helmut, editor, Trzebski, Andrzej, editor, and O’Regan, Ronan G., editor
Published: 1990
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16. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author: Anttalainen, U., Barbé, F., Bonsignore, M.R., Basoglu, O., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Grote, L., Kent, B.D., Lena, Lavie, Lavie, P., Levy, P., Lombardi, C., Marrone, O., Masa, J.F., McNicholas, W.T., Montserrat, J.M., Parati, G., Penzel, T., Pépin, J.L., Plywaczewski, R., Pretl, M., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S.E., Schulz, R., Sliwinski, P., Staats, R., Steiropoulos, P., Tasbakan, M.S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., Zielinski, J., Riha, Renata L., Kotoulas, Serafeim – Chrysovalantis, Pataka, Athanasia, Kvamme, John Arthur, Joppa, Pavol, and Hedner, Jan
Published: 2021
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17. Effects of Hypoxia on Adipose Tissue Expression of NFκB, IκBα, IKKγ and IKAP in Patients with Chronic Obstructive Pulmonary Disease

Author: Tkacova, R., Ukropec, J., Skyba, P., Ukropcova, B., Pobeha, P., Kurdiova, T., Joppa, P., Klimes, I., Tkac, I., and Gasperikova, D.
Published: 2013
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18. Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort

Author: Bonsignore, Maria R., Pepin, Jean-Louis, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschalis, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B. D., Kumor, M., Kurki, S., Kvamme, J. A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J. F., Montserrat, J. M., Parati, G., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., Zielinski, J., Bonsignore, M, Pepin, J, Anttalainen, U, Schiza, S, Basoglu, O, Pataka, A, Steiropoulos, P, Dogas, Z, Grote, L, Hedner, J, Mcnicholas, W, Marrone, O, Barbé, F, Bielicki, P, Bouloukaki, I, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kent, B, Kumor, M, Kurki, S, Kvamme, J, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Masa, J, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schulz, R, Sliwinski, P, Staats, R, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Bonsignore, Maria R., Pepin, Jean-Loui, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschali, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B.D., Kumor, M., Kurki, S., Kvamme, J.A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J.F., Montserrat, J.M., Parati, G., Penzel, T., Pépin, J.L., Plywaczewski, R., Pretl, M., Riha, R.L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M.S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., and Zielinski, J.
Subjects: Adult, Male, obesity, medicine.medical_specialty, Cognitive Neuroscience, Polysomnography, Population, Settore MED/10 - Malattie Dell'Apparato Respiratorio, ta3111, Cohort Studies, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, obstructive sleep apnea, asthma, ESADA cohort, Internal medicine, Epidemiology, gender, Medicine, Humans, Prospective Studies, education, Physician's Role, Asthma, Aged, education.field_of_study, Sleep Apnea, Obstructive, medicine.diagnostic_test, business.industry, ta1184, sleep-disordered breathing, Sleep apnea, General Medicine, Middle Aged, medicine.disease, Obesity, respiratory tract diseases, Obstructive sleep apnea, Europe, Cross-Sectional Studies, 030228 respiratory system, Cohort, epidemiology, Female, Self Report, business, 030217 neurology & neurosurgery
Abstract: Obstructive sleep apnea (OSA) and asthma are often associated and several studies suggest a bidirectional relationship between asthma and OSA. This study analyzed the characteristics of patients with suspected OSA from the European Sleep Apnea Database according to presence/absence of physician-diagnosed asthma. Cross-sectional data in 16,236 patients (29.1% female) referred for suspected OSA were analyzed according to occurrence of physician-diagnosed asthma for anthropometrics, OSA severity and sleepiness. Sleep structure was assessed in patients studied by polysomnography (i.e. 48% of the sample). The prevalence of physician-diagnosed asthma in the entire cohort was 4.8% (7.9% in women, 3.7% in men, p&nbsp
Published: 2018

19. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database

Author: Dieltjens, M. Verbraecken, J.A. Hedner, J. Vanderveken, O.M. Steiropoulos, P. Kvamme, J.A. Saaresranta, T. Tkacova, R. Marrone, O. Dogas, Z. Schiza, S. Grote, L. Steiropoulos, P. Verbraecken, J. Petiet, E. Trakada, G. Montserrat, J.M. Fietze, I. Penzel, T. Ludka, O. Rodenstein, D. Masa, J.F. Bouloukaki, I. Schiza, S. Kent, B. McNicholas, W.T. Ryan, S. Riha, R.L. Kvamme, J.A. Schulz, R. Grote, L. Hedner, J. Zou, D. Pépin, J.L. Levy, P. Bailly, S. Lavie, L. Lavie, P. Hein, H. Basoglu, O.K. Tasbakan, M.S. Varoneckas, G. Joppa, P. Tkacova, R. Staats, R. Barbé, F. Lombardi, C. Parati, G. Drummond, M. van Zeller, M. Bonsignore, M.R. Marrone, O. Escourrou, P. Roisman, G. Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. Anttalainen, U. Saaresranta, T. Sliwinski, P. Plywaczewski, R. Bielicki, P. Zielinski, J. ESADA collaborators
Subjects: health services administration, mental disorders, humanities
Abstract: Objective/Background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA). Patients/Methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Anthropometrics, comorbidities, apnea severity obtained by polygraphy or polysomnography, and daytime sleepiness [Epworth Sleepiness Scale (ESS)] were assessed. The CGI 7-point scale was completed at the end of the diagnostic process (CGI-severity, ie, CGI-S) and, in a subpopulation, at treatment follow-up (CGI-Improvement). Results: CGI-S was rated mild to moderate in 44% of patients. CGI rating at any given apnea intensity was worse in women than in men (p < 0.01). Patients undergoing polygraphy (n = 5075) were more frequently rated as severely ill compared to those studied with polysomnography (19.0% vs 13.0%, p < 0.001). In patients aged ≤65 years, CGI scoring was generally better than in the elderly despite a similar degree of OSA (eg, ‘normal, not ill’ 24.2% vs 15.3%, p < 0.01, respectively). Independent predictors of CGI rating included age, BMI, AHI, ESS, cardio-metabolic comorbidities, and diagnosis based on polygraphy. CGI-improvement rating (Beta = −0.406, p < 0.01) was superior to sleep apnea severity or ESS-score (Beta = 0.052 and −0.021, p = 0.154 and 0.538 respectively) at baseline for prediction of good CPAP compliance at follow-up. Conclusions: CGI rating is confounded by gender, age class and the type of sleep diagnostic method. As OSA phenotypes differ, CGI may contribute as a clinical tool to reflect the significance of clinical disease. © 2018 Elsevier B.V.
Published: 2019

20. European hospital adherence to GOLD recommendations for chronic obstructive pulmonary disease (COPD) exacerbation admissions

Author: Roberts, C Michael, Lopez-Campos, Jose Luis, Pozo-Rodriguez, Francisco, Hartl, Sylvia, Roberts, CM, Hartl, S, Lopez-Campos, JL, Pozo-Rodríguez, F, López-Campos, JL, Castro-Acosta, A, Abraira-Santos, V, López-Quilez, A, Dorado, J, Burghuber, O, Kohansal, R, Janssens, W, Siggsgaard, T, Heinen, V, Miculinic, N, Puretic, H, Tzanakis, N, Nontas Kosmas, E, Farrugia Jones, C, Chorostowska-Wynimko, J, Sowula, G, McCormack, S, McDonell, T, Mihaltan, F, AlexandruBogdan, M, Munteanu, I, Solovic, I, Tkacova, R, Pozo-Rodríguez, F, Ancochea, J, Stolz, D, Polatli, M, Şen, E, Bucknall, C, Welham, S, Routh, C, Haan, M, Zarelli, M, Lechat, E, Buckingham, RJ, and Joos, G
Published: 2013
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21. Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort

Author: Bonsignore, M, Pepin, J, Anttalainen, U, Schiza, S, Basoglu, O, Pataka, A, Steiropoulos, P, Dogas, Z, Grote, L, Hedner, J, Mcnicholas, W, Marrone, O, Barbé, F, Bielicki, P, Bouloukaki, I, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kent, B, Kumor, M, Kurki, S, Kvamme, J, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Masa, J, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schulz, R, Sliwinski, P, Staats, R, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Bonsignore, Maria R., Pepin, Jean-Louis, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschalis, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B. D., Kumor, M., Kurki, S., Kvamme, J. A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J. F., Montserrat, J. M., Parati, G., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., Zielinski, J., Bonsignore, M, Pepin, J, Anttalainen, U, Schiza, S, Basoglu, O, Pataka, A, Steiropoulos, P, Dogas, Z, Grote, L, Hedner, J, Mcnicholas, W, Marrone, O, Barbé, F, Bielicki, P, Bouloukaki, I, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kent, B, Kumor, M, Kurki, S, Kvamme, J, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Masa, J, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schulz, R, Sliwinski, P, Staats, R, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Bonsignore, Maria R., Pepin, Jean-Louis, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschalis, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B. D., Kumor, M., Kurki, S., Kvamme, J. A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J. F., Montserrat, J. M., Parati, G., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., and Zielinski, J.
Abstract: Obstructive sleep apnea (OSA) and asthma are often associated and several studies suggest a bidirectional relationship between asthma and OSA. This study analyzed the characteristics of patients with suspected OSA from the European Sleep Apnea Database according to presence/absence of physician-diagnosed asthma. Cross-sectional data in 16,236 patients (29.1% female) referred for suspected OSA were analyzed according to occurrence of physician-diagnosed asthma for anthropometrics, OSA severity and sleepiness. Sleep structure was assessed in patients studied by polysomnography (i.e. 48% of the sample). The prevalence of physician-diagnosed asthma in the entire cohort was 4.8% (7.9% in women, 3.7% in men, p < 0.0001), and decreased from subjects without OSA to patients with mild–moderate and severe OSA (p = 0.02). Obesity was highly prevalent in asthmatic women, whereas BMI distribution was similar in men with and without physician-diagnosed asthma. Distribution of OSA severity was similar in patients with and without physician-diagnosed asthma, and unaffected by treatment for asthma or gastroesophageal reflux. Asthma was associated with poor sleep quality and sleepiness. Physician-diagnosed asthma was less common in a sleep clinic population than expected from the results of studies in the general population. Obesity appears as the major factor raising suspicion of OSA in asthmatic women, whereas complaints of poor sleep quality were the likely reason for referral in asthmatic men.
Published: 2018

22. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author: Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., and Vitols, A.
Abstract: The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1,415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non-obese (body mass index <30 kg/m2) patients, positive airway pressure treatment was associated with an increased body mass index and waist circumference (0.4 [0.3–0.5] kg/m2 and 0.8 [0.4–1.2] cm, respectively, all p < 0.05), and weight gain was significantly associated with higher positive airway pressure compliance and longer positive airway pressure treatment duration. In the obese subgroup, body mass index was reduced after positive airway pressure treatment (−0.3 [−0.5 to −0.1] kg/m2, p < 0.05) mainly in patients with a strong reduction in Epworth Sleepiness Scale. In conclusion, positive airway pressure therapy was not found to systematically change body mass index in the European Sleep Apnea Database cohort, but the response was heterogeneous. Our findings suggest that weight gain may be restricted to an obstructive sleep apnea phenotype without established obesity. Lifestyle intervention needs to be considered in both lean and obese patients with obstructive slee
Published: 2018

23. Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Author: Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., Vitols, A., Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., and Vitols, A.
Abstract: Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results: There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion: OSA severity was independently associated with cholesterol and TG concentrations.
Published: 2018

24. Effects of sleep apnea and kidney dysfunction on objective sleep quality in nondialyzed patients with chronic kidney disease: An ESADA study

Author: Marrone, O. Cibella, F. Roisman, G. Sliwinski, P. Joppa, P. Basoglu, O.K. Bouloukaki, I. Schiza, S. Pataka, A. Staats, R. Verbraecken, J. Hedner, J. Grote, L. Bonsignore, M.R. Anttalainen, U. Saaresranta, T. Bailly, S. Pépin, J.-L. Tamisier, R. Basoglu, O.K. Tasbakan, S. Bonsignore, M.R. Cibella, F. Bouloukaki, I. Schiza, S. Dogas, Z. Drummond, M. von Zeller, M. Escourrou, P. Roisman, G. Fietze, I. Penzel, T. Grote, L. Hedner, J. Zou, D. Gouveris, H. Joppa, P. Tkacova, R. Hein, H. Kent, B.D. McNicholas, W.T. Ryan, S. Kvamme, J.A. Lombardi, C. Parati, G. Ludka, O. Mihaicuta, S. Pataka, A. Plywaczewski, R. Sliwinski, P. Pretl, M. Riha, R. Staats, R. Steiropoulos, P. Trakada, G. Verbraecken, J. ESADA study group
Subjects: urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract: Study Objectives: Patients with chronic kidney disease (CKD) often report poor sleep quality, but they commonly exhibit OSA. The aim of this study was to evaluate the influence of OSA severity and of estimated glomerular filtration rate impairment on objective sleep quality in nondialyzed patients with CKD, defined as an estimated glomerular filtration rate
Published: 2020

25. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author: Gunduz, C. Basoglu, O.K. Kvamme, J.A. Verbraecken, J. Anttalainen, U. Marrone, O. Steiropoulos, P. Roisman, G. Joppa, P. Hein, H. Trakada, G. Hedner, J. Grote, L. Steiropoulos, P. Verbraecken, J. Petiet, E. Montserrat, J.M. Fietze, I. Penzel, T. Ludka, O. Rodenstein, D. Masa, J.F. Bouloukaki, I. Schiza, S. Kent, B. McNicholas, W.T. Ryan, S. Riha, R.L. Kvamme, J.A. Hein, H. Schulz, R. Grote, L. Hedner, J. Zou, D. Pépin, J.L. Levy, P. Bailly, S. Lavie, L. Lavie, P. Basoglu, O.K. Tasbakan, M.S. Varoneckas, G. Joppa, P. Tkacova, R. Staats, R. Barbé, F. Lombardi, C. Parati, G. Drummond, M. van Zeller, M. Bonsignore, M.R. Petitjean, M. Roisman, G. Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. Anttalainen, U. Saaresranta, T. Plywaczewski, R. Sliwinski, P. Bielicki, P. the European Sleep Apnea Database collaborators
Abstract: Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies. © 2020 Elsevier B.V.
Published: 2020

26. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author: Riha, Renata L., primary, Kotoulas, Serafeim – Chrysovalantis, additional, Pataka, Athanasia, additional, Kvamme, John Arthur, additional, Joppa, Pavol, additional, Hedner, Jan, additional, Anttalainen, U., additional, Barbé, F., additional, Bonsignore, M.R., additional, Basoglu, O., additional, Bielicki, P., additional, Bouloukaki, I., additional, Dogas, Z., additional, Dorkova, Z., additional, Escourrou, P., additional, Fietze, I., additional, Esquinas, C., additional, Grote, L., additional, Kent, B.D., additional, Lena, Lavie, additional, Lavie, P., additional, Levy, P., additional, Lombardi, C., additional, Marrone, O., additional, Masa, J.F., additional, McNicholas, W.T., additional, Montserrat, J.M., additional, Parati, G., additional, Penzel, T., additional, Pépin, J.L., additional, Plywaczewski, R., additional, Pretl, M., additional, Rodenstein, D., additional, Roisman, G., additional, Ryan, S., additional, Saaresranta, T., additional, Schiza, S.E., additional, Schulz, R., additional, Sliwinski, P., additional, Staats, R., additional, Steiropoulos, P., additional, Tasbakan, M.S., additional, Tkacova, R., additional, Varoneckas, G., additional, Verbraecken, J., additional, Vitols, A., additional, Vrints, H., additional, and Zielinski, J., additional
Published: 2021
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27. Acute hemodynamic effects of non-invasive ventilation in patients with obesity hypoventilation syndrome

Author: Pobeha, P-, primary, Paranicova, I., additional, Trojova, I., additional, Tkacova, R., additional, and Joppa, P., additional
Published: 2021
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28. Clinical presentations of OSA in adults

Author: Tkacova, R., primary and Dorkova, Z., additional
Published: 2010
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29. Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study

Author: Marrone, O, Battaglia, S, Steiropoulos, P, Basoglu, O, Kvamme, J, Ryan, S, Pepin, J, Verbraecken, J, Grote, L, Hedner, J, Bonsignore, M, Anttalainen, U, Saaresranta, T, Barbé, F, Tasbakan, S, Bielicki, P, Kumor, M, Dumitrascu, R, Schulz, R, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Mcnicholas, W, Lévy, P, Pépin, J, Tamisier, R, Lavie, L, Lavie, P, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Rodenstein, D, Tkacova, R, Varoneckas, G, Vrints, H, Vitols, A., LOMBARDI, CAROLINA, PARATI, GIANFRANCO, ESADA Study Grp, Marrone, O., Battaglia, S., Steiropoulos, P., Basoglu, O., Kvamme, J., Ryan, S., Pepin, J., Verbraecken, J., Grote, L., Hedner, J., Bonsignore, M., Marrone, O, Battaglia, S, Steiropoulos, P, Basoglu, O, Kvamme, J, Ryan, S, Pepin, J, Verbraecken, J, Grote, L, Hedner, J, Bonsignore, M, Anttalainen, U, Saaresranta, T, Barbé, F, Tasbakan, S, Bielicki, P, Kumor, M, Dumitrascu, R, Schulz, R, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Mcnicholas, W, Lévy, P, Pépin, J, Tamisier, R, Lavie, L, Lavie, P, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Rodenstein, D, Tkacova, R, Varoneckas, G, Vrints, H, and Vitols, A
Subjects: Male, Comorbidity, Body Mass Index, Cohort Studies, Behavioral Neuroscience, 0302 clinical medicine, Risk Factors, Prevalence, obstructive sleep apnea, Aged, 80 and over, Sex Characteristics, Sleep Apnea, Obstructive, Medicine (all), Sleep apnea, General Medicine, Middle Aged, Europe, Hypertension, Cardiology, nephropathy, epidemiology, Female, Glomerular Filtration Rate, Cohort study, Adult, medicine.medical_specialty, Adolescent, Polysomnography, Cognitive Neuroscience, Renal function, Settore MED/10 - Malattie Dell'Apparato Respiratorio, ta3111, Nephropathy, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Obesity, Renal Insufficiency, Chronic, Aged, Heart Failure, hypoxia, business.industry, medicine.disease, Oxygen, Obstructive sleep apnea, Cross-Sectional Studies, 030228 respiratory system, Heart failure, Physical therapy, Human medicine, business, Body mass index, 030217 neurology & neurosurgery, Kidney disease
Abstract: The cross-sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate = 30) was found in 34% of subjects. The lowest nocturnal oxygen saturation was 81 +/- 10.2%. Chronic kidney disease prevalence in the whole sample was 8.7% or 6.1%, according to the Modification of Diet in Renal Disease or the Chronic Kidney Disease-Epidemiology Collaboration equations, respectively. Subjects with lower estimated glomerular filtration rate were older, more obese, more often female, had worse obstructive sleep apnea and more co-morbidities (P < 0.001, each). With both equations, independent predictors of estimated glomerular filtration rate < 60 were: chronic heart failure; female gender; systemic hypertension; older age; higher body mass index; and worse lowest nocturnal oxygen saturation. It was concluded that in obstructive sleep apnea, chronic kidney disease is largely predicted by co-morbidities and anthropometric characteristics. In addition, severe nocturnal hypoxaemia, even for only a small part of the night, may play an important role as a risk factor for kidney dysfunction.
Published: 2016

30. Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes

Author: Schroner, Z., Javorsky, M., Tkacova, R., Klimcakova, L., Dobrikova, M., Habalova, V., Kozarova, M., Zidzik, J., Rudikova, M., and Tkac, I.
Published: 2011
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31. Superior hypertension control with betablockade in the European Sleep Apnea Database

Author: Svedmyr, S, primary, Hedner, J, additional, Zou, D, additional, Parati, G, additional, Ryan, S, additional, Hein, H, additional, Pepin, J.L, additional, Tkacova, R, additional, Marrone, O, additional, Schiza, S, additional, Basoglu, O.K, additional, and Grote, L, additional
Published: 2020
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32. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author: Gunduz, Canan, primary, Basoglu, Ozen K., additional, Kvamme, John Arthur, additional, Verbraecken, Johan, additional, Anttalainen, Ulla, additional, Marrone, Oreste, additional, Steiropoulos, Paschalis, additional, Roisman, Gabriel, additional, Joppa, Pavol, additional, Hein, Holger, additional, Trakada, Georgia, additional, Hedner, Jan, additional, Grote, Ludger, additional, Steiropoulos, P., additional, Verbraecken, J., additional, Petiet, E., additional, Trakada, G., additional, Montserrat, J.M., additional, Fietze, I., additional, Penzel, T., additional, Ondrej, L., additional, Rodenstein, D., additional, Masa, J.F., additional, Bouloukaki, I., additional, Schiza, S., additional, Kent, B., additional, McNicholas, W.T., additional, Ryan, S., additional, Riha, R.L., additional, Kvamme, J.A., additional, Hein, H., additional, Schulz, R., additional, Grote, L., additional, Hedner, J., additional, Zou, D., additional, Pépin, J.L., additional, Levy, P., additional, Bailly, S., additional, Lavie, L., additional, Lavie, P., additional, Basoglu, O.K., additional, Tasbakan, M.S., additional, Varoneckas, G., additional, Joppa, P., additional, Tkacova, R., additional, Staats, R., additional, Barbé, F., additional, Lombardi, C., additional, Parati, G., additional, Drummond, M., additional, van Zeller, M., additional, Bonsignore, M.R., additional, Marrone, O., additional, Petitjean, M., additional, Roisman, G., additional, Pretl, M., additional, Vitols, A., additional, Dogas, Z., additional, Galic, T., additional, Pataka, A., additional, Anttalainen, U., additional, Saaresranta, T., additional, Plywaczewski, R., additional, Sliwinski, P., additional, and Bielicki, P., additional
Published: 2020
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33. Erickson Solution-Focused Health Coaching: an Innovative Approach for Sustainable Nutrition

Author: Tkacova, R, primary
Published: 2020
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34. Adipose tissue ageing and inflammation in COPD: obesity versus cachexia: T1:OS4.1

Author: Ukropcova, B, Skyba, P, Pobeha, P, Kurdiova, T, Joppa, P, Klimes, I, Tkac, I, Ukropec, J, Gasperikova, D, and Tkacova, R
Published: 2010

35. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author: Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L, ESADA Study Group., ESADA Study Grp, Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, and Vitols, A
Subjects: Data Analysis, Male, Time Factors, Excessive daytime sleepiness, Weight Gain, excessive daytime sleepine, Body Mass Index, Cohort Studies, Behavioral Neuroscience, 0302 clinical medicine, Positive airway pressure, Medicine, Longitudinal Studies, Prospective Studies, obstructive sleep apnea, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Epworth Sleepiness Scale, Sleep apnea, General Medicine, Middle Aged, weight, central obesity, positive airway pressure, ESADA cohort, Europe, Obesity, Abdominal, Cardiology, Female, Waist Circumference, medicine.symptom, Adult, medicine.medical_specialty, Cognitive Neuroscience, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, Humans, Aged, business.industry, Body Weight, body weight, central obesity, excessive daytime sleepiness, obstructive sleep apnea, positive airway pressure, ta3121, medicine.disease, Obesity, respiratory tract diseases, Obstructive sleep apnea, 030228 respiratory system, Human medicine, business, Body mass index, Weight gain, 030217 neurology & neurosurgery
Abstract: The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non- obese (body mass index
Published: 2018

36. Effects of CPAP on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome: P207

Author: DORKOVA, Z., PETRASOVA, D., MOLCANYIOVA, A., POPOVNAKOVA, M., and TKACOVA, R.
Published: 2008

37. Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

Author: Pataka, Athanasia Bonsignore, Maria R. Ryan, Silke Riha, Renata L. Pepin, Jean-Louis Schiza, Sofia Basoglu, Ozen K. and Sliwinski, Pawel Ludka, Ondrej Steiropoulos, Paschalis and Anttalainen, Ulla McNicholas, Walter T. Hedner, Jan Grote, Ludger Steiropoulos, P. Verbraecken, J. Petiet, E. and Trakada, G. Montserrat, J. M. Fietze, I. Penzel, T. and Ludka, O. Rodenstein, D. Masa, J. F. Bouloukaki, I. and Schiza, S. Kent, B. McNicholas, W. T. Ryan, S. Riha, R. L. Kvamme, J. A. Schulz, R. Grote, L. Hedner, J. and Pepin, J-L. Levy, P. Lavie, L. Lavie, P. Hein, H. and Basoglu, O. K. Tasbakan, M. S. Varoneckas, G. Joppa, P. and Safarik, P. J. Tkacova, R. Staats, R. Barbe, F. and Lombardi, C. Parati, G. Drummond, M. van Zeller, M. and Bonsignore, M. R. Marrone, O. Escourrou, P. Roisman, G. and Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. and Anttalainen, U. Saaresranta, T. Sliwinski, P. Plywaczewski, R. Bielicki, P. ESADA Study Grp
Published: 2019

38. Initiating treatment with auto-CPAP in patients with severe obstructive sleep apnea and arterial hypertension: effects on systemic blood pressure and heart rate: P384

Author: DORKOVA, Z. and TKACOVA, R.
Published: 2006

39. Night-to-night alterations in sleep apnea type in patients with heart failure

Author: TKACOVA, R., WANG, H., and BRADLEY, T. D.
Published: 2006

40. Clinical phenotypes and comorbidity in European sleep apnoea patients

Author: Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., Zielinski J., Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, ESADA Study Group, Ege Üniversitesi, ESADA Study Grp, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Saaresranta, T., Hedner, J., Bonsignore, M., Riha, R., Mcnicholas, W., Penzel, T., Anttalainen, U., Kvamme, J., Pretl, M., Sliwinski, P., Verbraecken, J., Grote, L., Barbé, F., Basoglu, B., Bielicki, P., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kumor, M., Kurki, S., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Marrone, O., Masa, J., Montserrat, J., Parati, G., Pataka, A., Pépin, J., Plywaczewski, R., Rodenstein, D., Roisman, G., Ryan, S., Schulz, R., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Vrints, H., and Zielinski, J.
Subjects: Male, Pulmonology, Physiology, Apnea, medicine.medical_treatment, lcsh:Medicine, Comorbidity, Polysomnography, Cardiovascular Medicine, Medicine (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), THERAPY, Body Mass Index, 0302 clinical medicine, Risk Factors, Positive airway pressure, Medicine and Health Sciences, Insomnia, Medicine, Prospective Studies, Continuous positive airway pressure, lcsh:Science, Prospective cohort study, Clinical Neurophysiology, Aged, 80 and over, Hypersomnia, Multidisciplinary, medicine.diagnostic_test, Sleep apnea, Middle Aged, DEPRESSION, PREVALENCE, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, Phenotype, Neurology, Physiological Parameters, Cardiovascular Diseases, CARDIOVASCULAR-DISEASE, Female, InformationSystems_MISCELLANEOUS, medicine.symptom, Engineering sciences. Technology, Hypopnea, INSOMNIA SYMPTOMS, Research Article, Adult, medicine.medical_specialty, Sleep Apnea, Adolescent, POSITIVE AIRWAY PRESSURE, Settore MED/10 - Malattie Dell'Apparato Respiratorio, White People, Young Adult, 03 medical and health sciences, Sleep Apnea Syndromes, DAYTIME, stomatognathic system, Comorbiditat, Diagnostic Medicine, Internal medicine, mental disorders, Humans, COMMON, Aged, HYPOPNEA, HYPERTENSION, business.industry, lcsh:R, Body Weight, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Biology and Life Sciences, ta3121, medicine.disease, Dyssomnias, respiratory tract diseases, nervous system diseases, ComputingMethodologies_PATTERNRECOGNITION, 030228 respiratory system, Physical therapy, lcsh:Q, Sleep Disorders, Physiological Processes, Sleep, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: PubMed ID: 27701416, Background Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well as impact on adherence to continuous positive airway pressure (CPAP) treatment have not been established. Methods A prospective follow-up cohort of adult patients with OSA (apnoea-hypopnoea index (AHI) of ?5/h) from 17 European countries and Israel (n = 6,555) was divided into four clinical presentation phenotypes based on daytime symptoms labelled as excessive daytime sleepiness ("EDS") and nocturnal sleep problems other than OSA (labelled as "insomnia"): 1) EDS (daytime+/nighttime-), 2) EDS/insomnia (daytime+/nighttime+), 3) non-EDS/noninsomnia (daytime-/nighttime-), 4) and insomnia (daytime-/nighttime+) phenotype. Results The EDS phenotype comprised 20.7%, the non-EDS/non-insomnia type 25.8%, the EDS/ insomnia type 23.7%, and the insomnia phenotype 29.8% of the entire cohort. Thus, clinical presentation phenotypes with insomnia symptoms were dominant with 53.5%, but only 5.6% had physician diagnosed insomnia. Cardiovascular comorbidity was less prevalent in the EDS and most common in the insomnia phenotype (48.9% vs. 56.8%, p
Published: 2016

41. Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

Author: Pataka, Athanasia, Bonsignore, Maria R., Ryan, Silke, Riha, Renata L., Pepin, Jean-Louis, Schiza, Sofia, Basoglu, Ozen K., Sliwinski, Pawel, Ludka, Ondrej, Steiropoulos, Paschalis, Anttalainen, Ulla, McNicholas, Walter T., Hedner, Jan, Grote, Ludger, Steiropoulos, P., Verbraecken, Johan, Petiet, E., Trakada, G., Montserrat, J. M., Fietze, I., Penzel, T., Ludka, O., Rodenstein, D., Masa, J. F., Bouloukaki, I., Schiza, S., Kent, B., McNicholas, W. T., Ryan, S., Riha, R. L., Kvamme, J. A., Schulz, R., Grote, L., Hedner, J., Pepin, J-L., Levy, P., Lavie, L., Lavie, P., Hein, H., Basoglu, O. K., Tasbakan, M. S., Varoneckas, G., Joppa, P., Safarik, P. J., Tkacova, R., Staats, R., Barbe, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Bonsignore, M. R., Marrone, O., Escourrou, P., Roisman, G., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Pataka, A., Anttalainen, U., Saaresranta, T., Sliwinski, P., Plywaczewski, R., Bielicki, P., ESADA Study Grp, Pataka A., Bonsignore M.R., Ryan S., Riha R.L., Pepin J.-L., Schiza S., Basoglu O.K., Sliwinski P., Ludka O., Steiropoulos P., Anttalainen U., McNicholas W.T., Hedner J., Grote L., Aristotle University of Thessaloniki, Università degli studi di Palermo - University of Palermo, University College Dublin [Dublin] (UCD), Royal Infirmary of Edinburgh, Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), University of Crete [Heraklion] (UOC), Ege university, National Institute of Tuberculosis and Lung Diseases, St. Anne’s University Hospital [Brno], Democritus University of Thrace (DUTH), University of Turku, Sahlgrenska University Hospital [Gothenburg], University of Gothenburg (GU), ESADA study group: P Steiropoulos, J Verbraecken, E Petiet, G Trakada, J M Montserrat, I Fietze, T Penzel, O Ludka, D Rodenstein, J F Masa, I Bouloukaki, S Schiza, B Kent, W T McNicholas, S Ryan, R L Riha, J A Kvamme, R Schulz, L Grote, J Hedner, J L Pepin, P Levy, L Lavie, P Lavie, H Hein, O K Basoglu, M S Tasbakan, G Varoneckas, P Joppa, R Tkacova, R Staats, F Barbe, C Lombardi, G Parati, M Drummond, M van Zeller, M R Bonsignore, O Marrone, P Escourrou, G Roisman, M Pretl, A Vitols, Z Dogas, T Galic, A Pataka, U Anttalainen, T Saaresranta, P Sliwinski, R Plywaczewski, P Bielicki, and SALAS, Danielle
Subjects: Male, obesity, Letter, Databases, Factual, Download, [SDV]Life Sciences [q-bio], cigarette smoking, Polysomnography, cancer risk, disease burden, apnea hypopnea index, sleep disordered breathing, study design, 0302 clinical medicine, polysomnography, Risk Factors, Nothing, cancer diagnosis, Neoplasms, middle aged, gender, Prevalence, 030212 general & internal medicine, Sleep study, obstructive sleep apnea, Sleep Apnea, Obstructive, education.field_of_study, anthropometry, quantitative analysis, medicine.diagnostic_test, adult, risk assessment, clinical trial, cohort analysis, prostate cancer, pulse oximetry, [SDV] Life Sciences [q-bio], Europe, not available, comorbidity, aged, female, waist hip ratio, colon cancer, priority journal, risk factor, factual database, disease severity, cerebrovascular accident, Pulmonary and Respiratory Medicine, medicine.medical_specialty, alcohol consumption, intermittent hypoxia, Population, MEDLINE, lymphoma, Settore MED/10 - Malattie Dell'Apparato Respiratorio, malignant neoplasm, cancer growth, 03 medical and health sciences, melanoma, medicine, cancer, cross-sectional study, Humans, controlled study, human, education, Cancer prevalence, hypoxia, business.industry, statistical model, Conflict of interest, prediction, major clinical study, body mass, oxygen saturation, lung cancer, multicenter study, Cross-Sectional Studies, Logistic Models, age, 030228 respiratory system, disease severity assessment, Family medicine, oxygen desaturation index, head and neck cancer, Human medicine, business, neoplasm
Abstract: [No abstract available], ResMed Foundation; Philips; European Respiratory Society, ERS; Fondation Air Liquide, Conflict of interest: A. Pataka has nothing to disclose. M.R. Bonsignore has nothing to disclose. S. Ryan has nothing to disclose. R.L. Riha has nothing to disclose. J-L. Pepin reports grants and research funds from Air Liquide Foundation, Agiradom, AstraZeneca, Fisher and Paykel, Mutualia, Philips, Resmed and Vitalaire, personal fees from Agiradom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed and Sefam. S. Schiza has nothing to disclose. O.K. Basoglu has nothing to disclose. P. Sliwinski has nothing to disclose. O. Ludka has nothing to disclose. P. Steiropoulos has nothing to disclose. U. Anttalainen has nothing to disclose. W.T. McNicholas has nothing to disclose. J. Hedner reports grants from ResMed Foundation, Philips Respironics and the European Respiratory Society, for start-up and conduct of the study. L. Grote reports grants from Resmed Foundation and Respironics Foundation, during the conduct of the study; personal fees for lecturing from Resmed, Philips and Itamar, grants from Resmed, other (equipment) from Itamar, outside the submitted work; in addition, L. Grote has a patent for sleep apnoea treatment pending., Support statement: The ESADA network has received support from the European Union COST action B26 and is currently a Clinical Research Collaboration funded by the European Respiratory Society. Additionally, the ESADA study group has received unrestricted seeding grants from the ResMed and the Philips Respironics Foundation for the establishment of the database in 2007 and 2011. The ESADA has an ongoing collaboration with Bayer AG. Non-financial support was provided by the European Sleep Research Society and the European Respiratory Society for communication, meetings and data presentations for the ESADA collaborators.
Published: 2019

42. Clinical phenotypes and comorbidity in European sleep apnoea patients

Author: Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., Zielinski J., Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., and Zielinski J.
Abstract: Background Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well as impact on adherence to continuous positive airway pressure (CPAP) treatment have not been established. Methods A prospective follow-up cohort of adult patients with OSA (apnoea-hypopnoea index (AHI) of ≥5/h) from 17 European countries and Israel (n = 6,555) was divided into four clinical presentation phenotypes based on daytime symptoms labelled as excessive daytime sleepiness ("EDS") and nocturnal sleep problems other than OSA (labelled as "insomnia"): 1) EDS (daytime+/nighttime-), 2) EDS/insomnia (daytime+/nighttime+), 3) non-EDS/noninsomnia (daytime-/nighttime-), 4) and insomnia (daytime-/nighttime+) phenotype. Results The EDS phenotype comprised 20.7%, the non-EDS/non-insomnia type 25.8%, the EDS/ insomnia type 23.7%, and the insomnia phenotype 29.8% of the entire cohort. Thus, clinical presentation phenotypes with insomnia symptoms were dominant with 53.5%, but only 5.6% had physician diagnosed insomnia. Cardiovascular comorbidity was less prevalent in the EDS and most common in the insomnia phenotype (48.9% vs. 56.8%, p<0.001) despite more severe OSA in the EDS group (AHI 35.0±25.5/h vs. 27.9±22.5/h, p<0.001, respectively). Psychiatric comorbidity was associated with insomnia like OSA phenotypes independent of age, gender and body mass index (HR 1.5 (1.188-1.905), p<0.001). The EDS phenotype tended to associate with higher CPAP usage (22.7 min/d, p = 0.069) when controlled for age, gender, BMI and sleep apnoea severity. Conclusions Phenotypes with insomnia symptoms comprised more than half of OSA patients and were more frequently linked with comorbidity than those with EDS, despite less severe OSA. CPAP usage was slightly higher in phenotypes with EDS.
Published: 2016

43. Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA

Author: Marrone, O, Cibella, F, Pépin, J, Grote, L, Verbraecken, J, Saaresranta, T, Kvamme, J, Basoglu, O, Mcnicholas, W, Hedner, J, Bonsignore, M, Anttalainen, U, Barbè, F, Tasbakan, S, Bielicki, P, Kumor, M, Bouloukaki, I, Schiza, S, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Ryan, S, Lévy, P, Tamisier, R, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Tkacova, R, Varoneckas, G, Pépin, JL, Kvamme, JA, Basoglu, OK, McNicholas, WT, Bonsignore, MR, Kent, BD, Masa, JF, Montserrat, JM, Marrone, O, Cibella, F, Pépin, J, Grote, L, Verbraecken, J, Saaresranta, T, Kvamme, J, Basoglu, O, Mcnicholas, W, Hedner, J, Bonsignore, M, Anttalainen, U, Barbè, F, Tasbakan, S, Bielicki, P, Kumor, M, Bouloukaki, I, Schiza, S, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Ryan, S, Lévy, P, Tamisier, R, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Tkacova, R, Varoneckas, G, Pépin, JL, Kvamme, JA, Basoglu, OK, McNicholas, WT, Bonsignore, MR, Kent, BD, Masa, JF, and Montserrat, JM
Abstract: Background: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. Methods: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 144), patients receiving fixed CPAP (fCPAP) (n = 1,178), and patients on autoadjusting CPAP (APAP) (n = 485). Results: In the whole sample, eGFR decreased over time. The rate of eGFR decline was significantly higher in the subgroup with eGFR above median (91.42 mL/min/1.73 m 2 ) at baseline (P <.0001 for effect of baseline eGFR). This decline was attenuated or absent (P <.0001 for effect of treatment) in the subgroup of patients with OSA treated by using fCPAP. A follow-up duration exceeding the median (541 days) was associated with eGFR decline in the untreated and APAP groups but not in the fCPAP group (P <.0001 by two-way ANOVA for interaction between treatment and follow-up length). In multiple regression analysis, eGFR decline was accentuated by advanced age, female sex, cardiac failure, higher baseline eGFR, and longer follow-up duration, whereas there was a protective effect of fCPAP. Conclusions: fCPAP but not APAP may prevent eGFR decline in OSA.
Published: 2018

44. Airway Hyperresponsiveness In COPD: A Marker Of Asthma-COPD Overlap Syndrome?

Author: Tkacova, R., Dai, D., Vonk, J.M., Leung, J., Hiemstra, P.S., Berge, M. van den, Kunz, L., Hollander, Z., Tashkin, D.P., Wise, R.A., Connett, J.E., Ng, R.T., McManus, B.M., Man, S., Postma, D.S., and Sin, D.D.
Published: 2016

45. Circulating Lipopolysaccharide-Binding Protein and Carotid Intima-Media Thickness in Obstructive Sleep Apnea

Author: TROJOVA, I., primary, KOZAROVA, M., additional, PETRASOVA, D., additional, MALACHOVSKA, Z., additional, PARANICOVA, I., additional, JOPPA, P., additional, and TKACOVA, R., additional
Published: 2018
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46. OSAS questionnaire to screen for fitness to drive evaluated in Slovakia

Author: Feketeova, E., primary, Mucska, I., additional, Klobucnikova, K., additional, Gresova, S., additional, Paranicova, I., additional, Stimmelova, J., additional, Trojova, I., additional, Rosenberger, J., additional, Dragasek, J., additional, Ferencova, M., additional, Donic, V., additional, and Tkacova, R., additional
Published: 2017
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47. Morbus Crouzon and severe obstructive sleep apnoea – case report

Author: Trojova, I., primary, Paranicova, I., additional, Schejbalova, A., additional, Pobeha, P., additional, Joppa, P., additional, and Tkacova, R., additional
Published: 2017
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48. Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study

Author: Tkacova, R, McNicholas, WT, Javorsky, M, Fietze, I, Sliwinski, P, Parati, G, Grote, L, Hedner, J, European Sleep Apnoea Database study collaborators, BONSIGNORE, Maria Rosaria, Tkacova, R, Mcnicholas, W, Javorsky, M, Fietze, I, Sliwinski, P, Parati, G, Grote, L, Hedner, J, McNicholas, WT, Bonsignore, MR, and European Sleep Apnoea Database study collaborators
Subjects: Pulmonary and Respiratory Medicine, Adult, Male, Adolescent, Databases, Factual, Cross-sectional study, Polysomnography, Settore MED/10 - Malattie Dell'Apparato Respiratorio, computer.software_genre, ta3111, Sleep apnoea, hypoxia, hypertension, Cohort Studies, Young Adult, stomatognathic system, medicine, Prevalence, Humans, apnea hypopnea index, oxygen desaturation index, blood pressure, Hypoxia, Aged, Aged, 80 and over, Sleep Apnea, Obstructive, Database, medicine.diagnostic_test, business.industry, Sleep apnea, Intermittent hypoxia, Cardiorespiratory fitness, Odds ratio, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Middle Aged, medicine.disease, Obesity, nervous system diseases, respiratory tract diseases, Europe, Cross-Sectional Studies, Hypertension, Female, business, computer, Cohort study
Abstract: Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but the pathophysiological mechanisms are incompletely understood. A collaborative European network of 24 sleep centres established a European Sleep Apnoea Database to evaluate cardiovascular morbidity associated with OSAS.11 911 adults referred with suspected OSAS between March 2007 and September 2013 underwent overnight sleep studies, either cardiorespiratory polygraphy or polysomnography. We compared the predictive value of the apnoea–hypopnoea index (AHI) and 4% oxygen desaturation index (ODI) for prevalent hypertension, adjusting for relevant covariates including age, smoking, obesity, dyslipidaemia and diabetes.Among patients (70% male, mean±sd age 52±12 years), 78% had AHI >5 events·h−1 and 41% systemic hypertension. Both AHI and ODI independently related to prevalent hypertension after adjustment for relevant covariates (pversus Q1 regarding ODI were 2.01 (1.61–2.51) and regarding AHI were 0.92 (0.74–1.15) (pThis cross sectional study suggests that chronic intermittent hypoxia plays an important role in OSAS-related hypertension.
Published: 2014

49. Diabetes mellitus prevalence and control in sleep-disordered breathing: The European Sleep Apnea Cohort (ESADA) study

Author: Kent, B, Grote, L, Ryan, S, Pépin, J, Bonsignore, M, Tkacova, R, Saaresranta, T, Verbraecken, J, Lévy, P, Hedner, J, McNicholas, W, Anttalainen, U, Barbe, F, Basoglu, O, Bielicki, P, Escourrou, P, Esquinas, C, Fietze, I, Hayes, L, Kumor, M, Kvamme, J, Lavie, L, Lavie, P, Marrone, O, Masa, J, Montserrat, J, Pataka, A, Penzel, T, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H., LOMBARDI, CAROLINA, PARATI, GIANFRANCO, Kent, B, Grote, L, Ryan, S, Pépin, J, Bonsignore, M, Tkacova, R, Saaresranta, T, Verbraecken, J, Lévy, P, Hedner, J, Mcnicholas, W, Anttalainen, U, Barbe, F, Basoglu, O, Bielicki, P, Escourrou, P, Esquinas, C, Fietze, I, Hayes, L, Kumor, M, Kvamme, J, Lavie, L, Lavie, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Kent, BD, Ryan, S, Pepin, JL, Bonsignore, MR, McNicholas, WT, and European Sleep Apnea Database collaborators
Subjects: Adult, Male, Pulmonary and Respiratory Medicine, Adolescent, Polysomnography, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Critical Care and Intensive Care Medicine, Severity of Illness Index, Regression Analysi, Cohort Studies, intermittent hypoxia, insulin resistance, HbA1C, Young Adult, Sleep Apnea Syndromes, Sleep Apnea Syndrome, Risk Factors, Prevalence, Humans, Prospective Studies, Israel, Aged, Glycated Hemoglobin, Aged, 80 and over, Cross-Sectional Studie, Hemoglobin A, Glycosylated, Risk Factor, Middle Aged, Europe, Prospective Studie, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Regression Analysis, Female, Cohort Studie, Cardiology and Cardiovascular Medicine, Human
Abstract: BACKGROUND: OSA is associated with an increased risk of cardiovascular morbidity. A driver of this is metabolic dysfunction and in particular type 2 diabetes mellitus (T2DM). Prior studies identifying a link between OSA and T2DM have excluded subjects with undiagnosed T2DM, and there is a lack of population-level data on the interaction between OSA and glycemic control among patients with diabetes. We assessed the relationship between OSA severity and T2DM prevalence and control in a large multinational population.METHODS: We performed a cross-sectional analysis of 6,616 participants in the European Sleep Apnea Cohort (ESADA) study, using multivariate regression analysis to assess T2DM prevalence according to OSA severity, as measured by the oxyhemoglobin desaturation index. Patients with diabetes were identified by previous history and medication prescription, and by screening for undiagnosed diabetes with glycosylated hemoglobin (HbA1c) measurement. The relationship of OSA severity with glycemic control was assessed in diabetic subjects.RESULTS: T2DM prevalence increased with OSA severity, from 6.6% in subjects without OSA to 28.9% in those with severe OSA. Despite adjustment for obesity and other confounding factors, in comparison with subjects free of OSA, patients with mild, moderate, or severe disease had an OR (95% CI) of 1.33 (1.04-1.72), 1.73 (1.33-2.25), and 1.87 (1.45-2.42) ( P < .001), respectively, for prevalent T2DM. Diabetic subjects with more severe OSA had worse glycemic control, with adjusted mean HbA1c levels 0.72% higher in patients with severe OSA than in those without sleep-disordered breathing (analysis of covariance, P < .001).CONCLUSIONS: Increasing OSA severity is associated with increased likelihood of concomitant T2DM and worse diabetic control in patients with T2DM.
Published: 2014

50. Consensus document on the management of patients with obstructive sleep apnea and hypertension

Author: Parati, G, Lombardi, C, Hedner, J, Grote, L, Tkacova, R, Levy, P, Riha, R, Bassetti, C, Siccoli, M, Narkievicz, K, Somers, V, Mancia, G, McNicholas, W., BONSIGNORE, Maria Rosaria, Parati, G, Lombardi, C, Hedner, J, Bonsignore, MR, Grote, L, Tkacova, R, Levy, P, Riha, R, Bassetti, C, Siccoli, M, Narkievicz, K, Somers, V, Mancia, G, and McNicholas, W
Subjects: hypertension, sleep disordered breathing, Settore MED/10 - Malattie Dell'Apparato Respiratorio
Published: 2010

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