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The main purpose of the article is to identify key factors of adaptive potential that can have a significant impact on counteracting crisis situations and increasing the level of financial security and business resilience of enterprises. The object of the study is determination of the factors of adaptive potential that directly affect the system of financial security and business sustainability of a enterprise. The scientific task is to model the hierarchical ordering of the key factors of adaptive potential according to the level of their significance in influencing crisis situations in the context of ensuring the financial security and business sustainability of enterprises. The research methodology involves the use of expert analysis methods with the additional use of the Delphi method, the method of hierarchical analysis, and graph theory. As a result of the study, a list of the most significant factors of adaptive potential for countering crisis situations was presented. As a result, the factors of adaptive potential are hierarchically ordered from the most significant to the least significant in ensuring the financial security of the enterprise. The innovativeness of the results obtained is revealed through the proposed approach to modeling the determination and order of factors of adaptive potential to counteract crisis situations. The study is limited by not taking into account the specifics of specific enterprises. Prospects for further research are aimed at taking into account the specific type of activity of enterprises for a specific country.

The article is devoted to the study of the impact on the development of future social workers’ social skills (soft skills). It is emphasized that today in the Ukrainian society, as a result of geopolitical, economic, demographic changes, as well as the state of war in the country, the level of expectations regarding creative solutions to various social problems by social workers and fast, clear and high-quality provision of social services has significantly increased. Citizens need prompt social support and trustful communicative interaction in social groups. The study used these research methods: analysis and generalisation of normative, psychological, pedagogical and sociological sources alongside educational and scientific programmes of Ukrainian higher education institutions on the investigated problem, including questionnaires intended for future social workers. The article identifies groups of soft skills that are considered by Ukrainian and foreign scholars, as well as by students themselves, as the most relevant for successful social work. We understand soft skills as the skills, abilities and characteristics that allow you to be competitive and successful in your professional activity. The essence of the factors influencing the development of social skills in students in higher education institutions is determined. The factors influencing the development of social skills of a future social worker are understood as the factors of objective and subjective nature belonging to the external and internal environment within which a student exists during curricular and extracurricular activities in a higher education institution; the ones which give impetus to the acquisition or improvement of certain soft skills in order to achieve a productive result in social activities. The external (global challenges and crises in the political, economic, technological, social, value-related, and educational spheres of society's functioning) and internal (ethical and moral life values, mental and motivational orientations, internal readiness for future social activities, social orientation to work with people, individual and personal development, intellectuality, level of professional competence, available experience of social work) factors of soft skills development in future social workers are substantiated and characterised. In the course of summarising the results of the analysis of the studied issues, it was concluded that it is necessary to take into account a set of factors of influence during the educational process in a higher education institution, since different factors actualise the development of different soft skills in students.

The article is devoted to the topical problems of employment modification at both the global and national levels. The aim of the study is to clarify global trends and allocate national features of modification of the structure of employment of the population. In the course of the study, the following methods were used: analysis and synthesis – to clarify the characteristic features of employment at the present stage of civilizational development; general and specific – to define key trends and features of employment modification at the global and national levels; induction and deduction – to identify factors influencing changes in the structure of employment and the content of labor in modern conditions. The key trends in employment modification at the global level are allocated as follows: changes in the content of work under the influence of the latest technologies, remote work, the growth of creative and intellectual industries, the growth of employment in the field of ecology, increase in demand for retraining and training, demographic changes. The author analyses features of modification of the sectoral structure of employment in Ukraine under the influence of globalization factors, world instability, the ongoing war, national features of functioning in an open economy. It is generalized that Industry 4.0 intensifies transformation processes and significantly modifies the structure of employment. The necessity of forming a new system of education and retraining of the workforce for the formation of modern skills and competencies is substantiated.

The article is devoted to the problem of developing future social workers’ social skills (soft skills). The relevance of the study is due to the public need for training competent and competitive social workers who are able to solve various social issues in society promptly and in a team, creatively perform social tasks, have motivation for self-development and self-realization. For this purpose, such research methods as the analysis and generalization of normative, literary sources, educational and scientific programs of higher educational institutions on the investigated problem, as well as questionnaires among students of higher education at bachelor's and master's levels – future social workers – were used. We understand soft skills as social skills – skills, abilities and characteristics that allow one to be competitive and successful in professional activities. As a result of the survey conducted among students of 9 institutions of higher education, it was found out that 10 skills are the most important soft skills of future social workers: knowledge of a foreign language, an active civic and life position, analytical thinking, communication skills, the ability to inspire new ideas, time management, the ability to build an algorithm of actions to provide the necessary social assistance to people, the ability to resolve conflicts, leadership qualities and the ability to lead, work organization skills. The necessary socio-pedagogical conditions for the effective development of future social workers’ soft skills at a higher education institution were defined and substantiated: the motivation and readiness of future social workers to develop soft skills necessary for successful social work; integration of the development of the complex of social skills "soft skills" in students in the process of educational work and during extracurricular practical social activities; availability and integrative implementation of various forms of "soft skills" development; use of a complex of innovative technologies and interactive methods of "soft skills" development; self-education through the involvement of students in practical social work beyond school hours. The set of factors affecting the introduction of socio-pedagogical conditions for the development of students’ social skills in institutions of higher education is characterized. Integration forms, innovative technologies and methods are highlighted, which are expedient to use in the educational process of modern institutions of higher education for the effective development of future social workers’ soft skills.

Abstract To date, pulmonary fibrosis remains an unmet medical need. In this study, we evaluated the potency of mesenchymal stromal cell (MSC) secretome components to prevent pulmonary fibrosis development and facilitate fibrosis resolution. Surprisingly, the intratracheal application of extracellular vesicles (MSC-EVs) or the vesicle-depleted secretome fraction (MSC-SF) was not able to prevent lung fibrosis when applied immediately after the injury caused by bleomycin instillation in mice. However, MSC-EV administration induced the resolution of established pulmonary fibrosis, whereas the vesicle-depleted fraction did not. The application of MSC-EVs caused a decrease in the numbers of myofibroblasts and FAPa+ progenitors without affecting their apoptosis. Such a decrease likely occurred due to their dedifferentiation caused by microRNA (miR) transfer by MSC-EVs. Using a murine model of bleomycin-induced pulmonary fibrosis, we confirmed the contribution of specific miRs (miR-29c and miR-129) to the antifibrotic effect of MSC-EVs. Our study provides novel insights into possible antifibrotic therapy based on the use of the vesicle-enriched fraction of the MSC secretome.

The formation of waviness on the working surfaces of bearing parts is associated with fluctuations in the size of the cut layer of metal and changes in the components of the cutting force. Laplace operators were used to model the centerless grinding system based on the construction of the transfer function and the characteristic equation. It was found that the formation of waviness depends on the position of the hodograph of the movement of the vector of the center of the part in the complex plane, which in turn depends on the geometric parameters of the rigid supports of the centerless grinder machine. This makes it possible, based on hodographs and the angular orientation of their asymptotes, to determine the geometric stability of the process depending on the angles of adjustment of the rigid supports of the grinder machine. Two methodological approaches were used to confirm the correctness of the hypotheses. The first one is a multiplication of wave’s hodographs. The second one is regeneration displacement and the coincidence of the combined hodograph of regeneration and waviness displacement mechanisms with the hodograph of infinitely rigid machine displacement. The diagrams which allow choosing geometry of adjustment of rigid support that allows to increase or decrease parameters of certain harmonics are developed. The 3D diagram allows setting the local minima, characterized by acceptable geometric adjustment conditions, providing regulated waviness of the working surfaces of bearing parts.

The entry of domestic products into European markets has set Ukrainian entrepreneurs the task - to increase their production, ensure safety, quality and competitiveness. The purpose of the study is to assess the safety and quality of sweet butter obtained from various domestic producers, and to determine its falsification by the generally accepted method and the developed patented express method. The object of the study was the assessment of organoleptic, physicochemical, microbiological parameters and falsification of sweet butter obtained from various milk processing enterprises of Ukraine: Lustdorf LLC and Fooddevelopment LLC, Vinnytsia region; TDV "Yagotinsky butter factory"; PE "SIMOL", Kyiv region; State Enterprise "Starokostiantyniv Dairy Plant", Khmelnytsky region. Analytical, organoleptic (appearance, color, consistency, smell, taste) were used to achieve the research goal; physicochemical (mass fraction of moisture, mass fraction of fat, titrated acidity of plasma oil and acidity of fatty phase of oil, mass fraction of sodium chloride, determination of margarine and vegetable fats), microbiological (KMAFАNM, the presence of Escherichia coli bacteria, pathogenic microorganisms, in particular genus Salmonella, species Listeria monocytogenes; molds) and variation-statistical research methods. Developed patented express method for detecting adulteration of sweet cream oil using resorcinol solution in benzene with a mass fraction of 5.0% and concentrated hydrochloric acid can be used in production laboratories at milk and dairy products, supermarkets, wholesale bases, shops and public laboratories. in laboratories of veterinary and sanitary examination in agro-industrial markets. The oil produced by different manufacturers according to organoleptic parameters: appearance, color, texture, smell and taste met the requirements of DSTU 4399: 2005. According to physical and chemical parameters, the samples of sweet butter also met DSTU 4399: 2005, except for sample № 5 (SE "Starokostiantyniv Dairy Plant" of Khmelnytsky region), which showed an increase of + 0.6% by weight of sodium chloride. Research has established the falsification of sweet cream oil according to the developed patented method, according to which the probability in the indicators was 99.9%, produced: TDV "Yagotinsky butter factory" - up to 1.5% (light purple color) oil and "Farm Peasant", manufacturer LLC Food Development "- from 1.6 to 5.0% (bright purple color). Microbiological parameters of sweet butter: KMAFANM, bacteria of the Escherichia coli group, bacteria of the genus Salmonella, species Listeria monocytogenes, as well as molds met the requirements of DSTU 4399: 2005.

See the retraction notice E3S Web of Conferences 549, 00001 (2024), https://doi.org/10.1051/e3sconf/202454900001

The purpose of the article is to continue the review of private and institutional libraries in the Library Fund of the National Museum of History of Ukraine. The authors introduce into scientific circulation new knowledge about Ukrainian bookplates (stickers) as sources for historical and biographical studies about everyday life and readers preferences of the appropriate period of history and owners of bookplates. Art analysis of samples of book graphics also is among purposes of the study. Research methodology: historical method, de visu, analysis and synthesis, systematization, classification and comparative analysis, problem chronological method, personal approach and description of books. Scientific novelty is realizes via detailed attribution and cataloging of all those bookplates (stickers) that are connected with Ukraine according birth or activity of their private owners and location of foundation of institutional owners, content of plots and their authors. Results of the study are presented in the first catalogue. Conclusions. New knowledge about all Ukrainian bookplates (stickers) (16 units) in the Museum Library Fund has been formed. New biographical and historical material as wellas the new material for Ukrainian studies and book studies has determined the relevance of continue studying of the museum book collections as well as individual study of little-known biographies of bookplates owners and activities of institutions to which libraries they belonged.

The primary task of the livestock industry is to provide the population with high-quality food products, and the industry with raw materials. For this, it is necessary to ensure a high level of productivity and safety of young pigs. Studies carried out in recent years indicate an increase in the incidence of gastrointestinal diseases among young farm animals, leading to a decrease in the immunobiological reactivity of the piglets' organism and significant damage to farms. When performing the research, we used zootechnical, zoohygienic, biochemical, immunological and variational-statistical research methods. Research work was carried out during 2010-2018 at the Department of Animal Hygiene and Fundamentals of Veterinary Medicine of the Bila Tserkva National Agrarian University. Scientific and economic experiments and production tests were carried out in the farms of Progress LLC (Uzin, Bila Tserkva district) and Denisenko LLC (Skvirsky district, Kyiv region). Experimental studies were carried out in the Problem Laboratory of Immunology, Department of Animal Hygiene and Fundamentals of Veterinary Medicine, interfaculty laboratory of biochemical and histochemical research methods. For the first time, the prebiotic Bio-active was used as a feed additive in the diet of young pigs on growing at industrial keeping, its positive effect on the safety, productivity, physiological and immunological state of their body was proved. For the first time, the optimal dose of the prebiotic Bio-active for growing pigs was established and a method of its use was developed. The optimal dose of the prebiotic Bio-active for growing young pigs is 5 g (5x107 CFU) per 10 kg of body weight when fed with compound feed once a day for 30 days, which contributes to an increase in the average daily weight gain of piglets by 17.2 % (P

The article is devoted to highlighting the peculiarities of the evolutionary economy. The characteristic features of evolutionary changes in the economic system are highlighted. Emphasis is placed on the methodological principles of the development of complex systems. The position that the evolution of the economy and society is based on the laws of nonlinear development is substantiated. The peculiarities of the functioning of the modern economic system on the basis of instability and nonlinearity are revealed. It is emphasized that evolutionary economics is a relatively new direction of economic science, which considers economic processes as spontaneous, open, and irreversible, due to the interaction of external and internal factors. Signs of evolutionary economics from the standpoint of a nonlinear paradigm are also highlighted. The author proposes to study the evolution of the banking system from the standpoint of a nonlinear paradigm.

Objective. The cytochrome 11B2 aldosterone synthase gene (CYP11B2) that links to aldosterone synthase enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes.

The Foresight technology is considered in world practice as an effective forecasting instrument, intended to research the future, or to prognose the future development of economic activities. Most of the authors consider the use of Foresight at national and global levels – through the theoretical or methodological aspects. Much less considered is the practice of applying Foresight at the regional level. Lack of experience on the practical application is one of the problems in increasing the competitiveness of regions in the prevailing conditions. The article considers the results of use of the method of critical technologies of Foresight concerning agricultural sector at the regional level. A region is regarded as a subject of competitive processes in the context of globalization. The purpose of the research is to determine the critical technology in AIC at the regional level, capable to implement in the final phase of the Foresight application to influence the industry production, markets, environment and, ultimately, competitiveness of the industry in the region. Outlining the scope of usage of Foresight, the authors consider the following key issues of the industry, which are: agri-ecological condition of the land; social issues – creation of workplaces in rural areas, provision of food production for the population, according to the medical norms and at affordable prices. The results of the research have found that the technology of keeping the dairy herd pasture-fed can become a critical technology, a potential factor in the revival of cattle breeding in the region. The presented approach will solve the problem of conservation of soil fertility as key competencies in development of the agri-industrial complex in the region, necessary for obtaining high yields of agricultural crops, and also allow to solve social problems with jobs creation, provision of the population with food products, according to the medical standards, and will impact the development of dairy products market.

The article is devoted to the study of the intensity of lead accumulation in the leaf mass and seeds of the milk thistle due to its fertilizers with various minerals. The medicinal properties of milk thistle and the risks that may occur when lead enters the human body are shown. The rate of accumulation and absorption of lead by the leaf mass and seeds of milk thistle was studied for the use of various fertilizer schemes: ammonia, phosphorus, potassium fertilizers, their mixtures and without the use of fertilizers. The obtained indicators are listed to establish the accumulation and hazard factors taking into account the maximum permissible concentrations. It is proved that with the use of fertilizers, less lead is accumulated by the plants of milk thistle using a mixture of ammonium nitrate, superphosphate simple and potassium chloride. The greatest accumulation of lead by seeds is observed when fertilizing milk thistle with spotted ammonium nitrate, and by leaf mass – when fertilizing with potassium chloride. The results of the research revealed intensive absorption and accumulation of leaf mass and seeds of thistle spotted lead in quantities that are significantly higher than the maximum permissible levels and puts the requirements for improving the cultivation of this crop in modern field crop rotation. It was found that the least amount of lead is accumulated in the leaf mass and the seeds of milk thistle in the absence of any fertilization of its crops. At application of fertilizers the least lead accumulates by plants of thistle spotted at application of a mixture of fertilizers of ammonium nitrate, simple phosphate and potassium chloride in application rate N – 60 kg / ha, P – 60 kg / ha, K – 60 kg / ha. The greatest accumulation of lead by seeds is observed in the fertilization of thistle spotted ammonium nitrate, and the leaf mass – in the fertilization of potassium chloride.

The thesis is devoted to the urgency of using structured water in crop production. Positive influence of structured water on germination energy and germination of seeds of radish sowing is shown. Prospects for the use of structured water in crop production have been determined.The stimulating effect of structured water on the germination energy and the laboratory germination of seeds of radish sowing seeds, compared to their germination on ordinary water by 13-20%, were revealed.In terms of its parameters, structured water is close to the physiological fluids of plant tissues. Structured water consists of large and small liquid crystals (clusters), increases its physiological activity in plant tissues, facilitates the penetration of water and ions dissolved in it through membranes and cell walls. The use of structured water can significantly save its amount by irrigation and increase the yield of cultivated crops in drought conditions.However, with the introduction of resource-saving technologies into production, changes in irrigation regimes, there is a need to study the effect of structured water on the germination of crops.Water and its quality play an important role in crop and agriculture. In particular, water is needed by plants as a solvent and transported nutrients for transpiration, plant cooling, etc. Water influences seed germination and determines field germination, also used for irrigation, crop spraying and fertilizer application. Therefore, the quality of the water depends on the quality of the water. Low crop yields can also be a consequence of poor and contaminated water. Water used for irrigation, irrigation, plant germination should carry a complex of nutrients and have a natural structure. The use of such water will facilitate the faster passage of the phenological phases of plant growth and development and, accordingly, a greater yield.

The high rate of urbanization in the modern world requires a conscious approach to architectural design. A person needs an environment that fills him with new strength and does not drown out his creative potential with monotonous routine. Due to its natural feature, fractal architecture meets these requirements. The article examines the signs of fractal systems in relation to architecture, highlights the concept - "the principle of fragmentation of a fractal", the term "self-similarity" is broader. In addition, the existing experience of fractal architecture has been analyzed, and the relationship between fractality and the success of the project has been revealed using the example of existing objects. The materials of this article can serve for the further development of the theory of creating fractal architecture.

Information about the worms’ production technology of spiroid cylindrical gears is given. A method of the profile analytical calculation of a disk abrasive tool is proposed, providing the possibility to profile grinding wheels for various types of ruled helical surfaces: Archimedean, convolute, involute, etc. The use of the calculation methodology makes it possible to achieve high accuracy in processing the active (working) side surfaces of a hardened grinding worm; it sharply reduces the wear intensity of the spiroid wheel associated with it, the ring gear of which is made of bronze.

The work represents a preliminary stage of resource research for the Daurian part of Zabaikalsky kray. The XIV edition of the State Pharmacopoeia of the Russian Federation (2018) includes 102 species of medicinal plants, of which 30 species are found in Zabaikalsky kray. Using the method of tentative estimation of the stocks of medicinal raw materials, we preliminarily divided pharmacopeial species into three groups. Raw materials of ten species can be harvested for the needs of the regional pharmacy network, eight species can be used for personal needs of the local population and only five widespread species (Pinus sylvestris, Betula pendula, Padus avium, Vacciniumvitis-idaea, Ledum palustre) can be a resource for the chemical and pharmaceutical industry of the Russian Federation. The remaining species Arctostaphylos uva-ursi, Vaccinium myrtillus, Carum carvi, Dryopteris filix-mas have single localities, and Glycyrrhiza uralensis, Rhodiola rosea, Convallaria keiskei included in the Red Book of the Trans-Baikal Territory (2017). Harvesting of these species is prohibited. It has been established that 15 species of medicinal plants are the most promising in terms of resource studies, and Dauria Yablonovaya and Dauria Argunskaya are the most promising territories for resource studies due to the greatest species diversity of pharmacopoeial medicinal plants in them.

The article is devoted to solving the problem of re-compaction of agricultural soils. The positive effect of growing six species of perennial grasses has been shown: sowing alfalfa, meadow clover, sand sainfoin, white clover, horned clover, eastern goatskin on the creation of an optimal bulk soil mass. The indicated indicator in the dynamics of the four-year period of growing leguminous perennial herbs is analyzed. The minimum period for growing leguminous perennial herbs has been established for which it is possible to achieve a stable and favorable bulk soil mass. The factors providing the optimal soil density during the cultivation of certain types of herbs, including the parameters of the root systems, soil cultivation and weather conditions, are justified. Based on the studies, a technology was developed to optimize the volumetric mass of the soil by selecting certain types of perennial leguminous herbs and the timing of their cultivation. The ability to optimize the bulk soil mass at the level of 1.13 – 1.18 g/cm3 for the third or fourth year of vegetation of leguminous perennial grasses has been proved.Іn the year of sowing of leguminous perennial grasses, the volume of soil mass depends largely on the basic tillage of the grasses under sowing and is determined by the magnitude and nature of precipitation. Since the second year of vegetation of leguminous perennial grasses, the bulk mass of the soil is determined by the peculiarities of propagation in the soil of the root systems of different types of grasses. There is a tendency to decrease the volume of soil under the legume of perennial grasses in the second year of their vegetation, followed by an increase in the third year and stabilize – in the fourth year of vegetation of grasses at an optimal level for the growth and development of cultivated plants. Among the perennial grasses, the soil of alfalfa is sown best, and the worst is sand asparagus.

Introduction. Obesity is considered a global problem of humanity of the third millennium. According to the World Health Organization, obesity is an epidemic non-infectious disease. About 30.0 % of the planet’s population is overweight or obese. This indicator is progressively increasing, because there is no country in the world where this disease is not registered. Obesity can cause a lot of concomitant diseases. It is not surprising that in patients with obesity the risk of developing acute pancreatitis increases. It is known that acute pancreatitis is an inflammatory disease of the pancreas. People with obesity have a potentially worse prognosis for the course of the disease and the development of complications. Available studies indicate a direct correlation between enlargement of parapancreatic tissue in patients with acute pancreatitis and body mass index (BMI) increase. The aim of the study is to find out the features of clinical indicators, course and complications of acute pancreatitis in patients with comorbid obesity. Materials and methods. In our work, we used a retrospective analysis. We have analyzed medical documentation of 567 patients, diagnosed with acute pancreatitis and treated at the “Kyiv Regional Clinical Hospital” from January 1, 2011 to February 2, 2019. The acute pancreatitis was diagnosed based on the criteria: pain in the epigastrium, nausea or vomiting within 48 hours prior to ingestion and increase in blood amylase more than triple. The study included patients who originally contacted the hospital. Patients with repeated cases of acute pancreatitis or exacerbation of chronic pancreatitis have been excluded from the study. Diagnosis of acute pancreatitis was confirmed by additional instrumental tests: ultrasound and computer tomography. Patients under the age of 18 years, those who were not examined fully and patients with oncological pathology were also excluded from the study. 85 patients were excluded from the study by matching exclusion criteria and 482 patients were analyzed in this study. Anthropometric examination was performed for all parameters, including sex, age, weight (kg), height (m), abdominal circumference (cm). Next concomitant diseases noted in analyzed patients medical records: diabetes type II (CD), arterial hypertension, dyslipidemia, chronic kidney disease, cardiovascular system diseases. Initially, for admitted patients a general blood test, a biochemical assay, the bacterioscopy of liquids, and a measurement of blood pressure were performed. Biliary etiology of acute pancreatitis was confirmed by the presence of concretions according to the results of ultrasound, computer tomography, or magnetic resonance cholangiopancreatography, as well as increased cholestatic enzymes (alkaline phosphatase, gamma-glutamyl trespeptidase). Alcohol genesis of the disease was concluded by the presence of alcohol and the absence of concretions, metabolic disorders (hypertriglyceridemia, hypercalcemia) or other causes that could cause acute pancreatitis (trauma, medicines, etc.). The initial assessment of the prognostic severity of the disease was calculated according to APACHEІI. The scale of assessment included 12 physiological indicators, age and health scores that were translated and summed up. The score ​​equal to or greater than 8 predicted a more severe course of the disease. The CT severity index was also calculated on the basis of computed tomography of the abdominal cavity with intravenous contrast after 7 days of hospitalization. The severity index of CT is the sum of pancreatic inflammation points (Baltаzar scale from 0 to 4) and pancreatic necrosis (from 0 to 6). The total score ranges from 0 to 10, respectively: up to 3 points – mild course, 4-6 points – moderate flow, 7 or more – severe course of acute pancreatitis. The obtained data were statistically processed in Exel 2010 using a descriptive method with relative, absolute numbers, mean square deviations and their errors. A correlation relationship between variables was studied using Pearson’s criterion (R2). The significance differences between the two independent groups were calculated using Students t-criterion. Results. In our study we had 482 patients, 260 patients (54.0 %) had obesity (the study group), for comparison, a control group of patients with normal body weight was chosen, the total number of which was 222 (46.0 %) patients. Obesity patients had a higher average age (55.4 ± 9.4 years, p = 0.01), also they had statistically greater percentage of severe cases of acute pancreatitis (85 (32.7 %) vs 16 (7.2 %); p = 0.01). We note the increase in the percentage of the course of severe pancreatitis in patients with weight gain from 10.20 % to 53.93 % (p = 0.03). Obesity patients had the longer bed-days in the hospital than in patients with normal body weight. In addition, they observed an increase of twice the bed in the reanimation and intensive care unit (5.8 ± 0.8 vs 2.7 ± 0.5 days, p = 0.01). When investigating the mortality rate, it should be noted that the main cause of death was the progression of organ failure of 30 (6.3 %), pulmonary embolism (TB) – 15 (3.1 %) and DIC 18 (3.7 %). Conclusions. The presence of obesity in patients involves a high risk of severe acute pancreatitis, this risk increases with an increase in the body mass index. In addition, obese patients are provided with a higher bed-day in-patient and in-patient-care settings, which increases the total cost of treatment and requires a cost-effective algorithm in the future. A high mortality rate in obese patients requires improved treatment algorithm.

The aim of the article is to investigate the influence of introducing democratic innovations in Ukraine on changes in the methodology for studying civil society finance. The importance of introducing democratic innovations for the democratization of the state and improving the quality of its governance is revealed. It is determined that the main democratic innovations in independent Ukraine were the referendum; creation of public organizations with the support of international funds, apartment building co-owners associations, endowments, the e-government system; introduction of inclusive elements of society management; social networks and groups in them, etc. The reasons for and normative regulation of the introduction of these democratic innovations are characterized. The analysis of the methodology for studying civil society finance in the historical context is carried out. It is noted that 2006 was a turning point both regarding the reasons for introducing the democratic innovations and the methodology for studying civil society finance. The existence of interrelationship between the introduction of the democratic innovations and changes in the methodology for studying civil society finance is substantiated. The basic principles to be observed when carrying out a modern scientific research of civil society finance are described. It is concluded that there are all prerequisites for implementing a high-quality comprehensive study of civil society finance in compliance with them.

The article presents the theoretical and methodological discourse of the concepts “food security”, “food insecurity”, “malnutrition”, “hunger” and their complementarity. The levels of food security and its range according to the USDA Food Safety Methodology are determined. The economic, social, political, climatic determinants of food insecurity are identified. The problem of prevalence of malnutrition and hunger in the world is considered. The strategic objectives of Global Food Security until 2030 are considered. The international experience of overcoming food insecurity is studied, and the effectiveness of state social programs is investigated. The importance of Ukraine’s participation in international food security programs is emphasized. The tasks and indicators of overcoming food insecurity in Ukraine by 2030 are described in accordance with the goals of sustainable development, in particular: ensuring the availability of balanced nutrition at the level of scientifically based standards for all segments of the population; increasing agricultural productivity, primarily through the use of innovative technologies; ensuring the creation of sustainable food production systems that contribute to the conservation of ecosystems and gradual improvement of soil quality; reducing food price volatility. The driving forces of food insecurity of the population and the possible ways to overcome them are determined.

The article is aimed at considering institutionalism as the basis for researching in the finance of civil society. The causes for emerging of institutionalism are considered and the relevance of its use as the basis of the outlined research is substantiated. The basic theories of civil society are analyzed, and as result the expediency of using the extended functional model developed by Christopher Spark for the civil society research is substantiated. Existing theories of civil society interaction with other sectors are analyzed. It is suggested to consider civil society as a sphere of interactions between the State, family and business. It is recommended that civil society finance research be carried out through an institutional approach, taking into account measurements of the functional impact. A multidisciplinary approach for research in the civil society finance is described.

У статті розглянуто сутність корпоратизації в контексті формування інтеграційної економіки. Акцентовано увагу на інтегративній ознаці економіки. Виявлено теоретичну сутність інтеграції та її економічна природу. Розкрито ознаки економічної системи за системним підходом. Акцентовано увагу на таких властивостях економічної системи, як: цілісність, ієрархічність та інтегративність. З’ясовано, що інтегративність економіки передбачає володіння економічною системою такими властивостями, які не є притаманними окремим її елементам. Підкреслено, що становлення корпоративної форми власності та організація економічних відносин сформували адекватне середовище й поклало початок процесам консолідації в економіці. Доведено, що корпоратизація економіки знімає перешкоди просторовим рамкам і темпам економічного розвитку, формує новий корпоративний вигляд ринкової системи й породжує інтеграційні процеси між компаніями. Аргументовано, що корпоратизація породжує інтеграційні процеси в економічній системі й знаходить вираження в консолідації суб’єктів економічної системи у формі злиття й поглинання. З’ясовано, що консолідація тісно пов’язана з ринкової корпоратизацією. Досліджено причинно-наслідкові зв’язки консолідації з функціонуванням корпоративного бізнесу, що є передумовою розвитку інтеграційної економіки. Підкреслено, що консолідація сприяє інтеграційним процесам зростання економіки держави.

The situation when groundwater considerably rises above the “normal” level, water intake, lowering of groundwater levels and other relevant practical tasks require the drainage facilities. The most effective techniques of numerical studies of the corresponding boundary problems at present time are methods of dealing with inverse boundary value problems (conformal and quasi-conformal mappings). As basis of this research we used the case of combining the fictitious domain methods with quasi-conformal mappings of the solution of nonlinear boundary value problems for the calculation of filtration regimes in environments with free boundary areas (depression curves) and zones of “mountainous” areas.

A new method for evaluating the bone status using the scattering parameter of hardness indexes (Weibull homogeneity coefficient m) is proposed. A comparative analysis of the condition of the bone tissue of birds, depending on age, breed and calcium content, is conducted. It is established that the scattering degree of mechanical properties, in particular, hardness, is a very structure-sensitive parameter.

The article is devoted to the study of the influence of heavy metals on the chemical composition of the green mass of legume perennial grasses. The accumulation of long-term grass beans with such heavy metals as lead, cadmium, copper and zinc was studied. It is established that the lowest amount of heavy metals in the green mass is accumulated by white clover, and the largest one is gazelle East. The analysis of the chemical composition of the green mass of legume perennial grasses for the content of heavy metals and nutrients. It is established that all the studied types of leguminous perennial grasses are characterized by an increased and balanced content of basic nutrients in conditions of contamination of lands with heavy metals. The regularity of nutrient decrease in feed with increasing concentration in plants of heavy metals is revealed. The most nutritious food in terms of chemical composition in conditions of soil contamination with heavy metals was white clover. A rectilinear relationship between the concentration of cadmium and the proportion of dry matter and BEP in the chemical composition of legume perennial grasses was established

The article analyzes of the problem of blended learning in higher education institutions. In particular, the article analyzes the legislative documents about the implementation of information technologies in the educational process, strategies for higher education, the introduction of distance learning, that determine importance of blended learning. The author also analyzes the concept of blended learning based on the definitions that are considered in the scientific and pedagogical literature. That analysis determines the ambiguity and incorrectness of the different definitions. It was proposed author's definition for this term. For order to identify the benefits of blended learning, it was analyzed of the positive and negative aspects of all technologies that are combined in the system of blended learning. Based on the analysis of different learning models, it was determined that the most optimal models is the station rotation model and the flipped classroom. The article provides an example of the use of a combination of these models for learning the topic "Computer Structure" by the students of the direction of training "Informatics". The education session was taking place in several stages and involves changing the five stations. Based on the conducted research was identified the general didactic and methodical principles of organization of blended learning.

The article is aimed at studying and evaluating competitiveness of the franchising tourism networks by the proposed options with the possibility to define the characteristics of the relevant tourism franchise at the national market of services. The dynamic changes of positions of Ukraine and of the countries-leaders in the ranking of competitiveness of the travel and tourism sector have been analyzed. The actual parameters of an evaluation of competitiveness of the franchising networks, operating at the domestic market of tourism services, have been defined and substantiated. For the implementation of quantitative evaluation of specific parameters, a questionnaire survey along with point rating of 50 tourism franchisee enterprises was conducted. The franchising networks which are leaders at the national tourism market were analyzed and defined. Based on the results obtained by calculations, a parametric model for evaluation of competitiveness of franchising tourism networks has been proposed and the key characteristics of a tourism franchise have been determined. Further researches will focus on the formation of a structured system for increasing the efficiency of interaction between the tourism enterprises in the franchising system and on the basic principles to ensure their competitiveness.

The Sixth Amendment to the United States Constitution enumerates a cluster of rights granted to criminal defendants and is designed to make criminal prosecutions more accurate, fair, and legitimate. The Confrontation Clause, which states that „In all criminal prosecutions, the accused shall enjoy the right…to be confronted with the witness against him” should not be underestimated. This article seeks to analyse the evolution of the Confrontation Clause and the extent of a defendant’s right to face-to-face confrontation. The article analyse the case Crawford v. Washington, which was a key shift in the Supreme Court’s Confrontation Clause jurisprudence.

This article considers different variants of natural gas supply in Ukraine which are based on the main tendencies of natural gas regional markets and some important factors, such as: possibility to use natural gas storage system, different changes in government regulation and innovations in the energy generation and supply sphere. The purpose of this work is to substantiate the current gas supply strategy in Ukraine on the basis of quantitative methods. The main results of the article are: Numerical estimation of the positive effect, gained from the using of natural gas storage system; Numerical estimation of the positive effect from the diversification of the natural gas supply in Ukraine in terms of decreasing the potential role of Gazprom monopoly. The population response evaluation on the gas price rising. This article provides an effective tool for assessing the possible consequences of decisions of state bodies when moving away from the existing monopoly of gas supply system and the macroeconomic effect of different gas supply options. The quantitative assessment of the gradual convergence of regional markets and the creation of a global natural gas market is proposed

The article clarifies the evolution of multiculturalism as a concept in artistic consciousness and fiction. The author pays attention on the fact that in recent decades the multiculturalist context has become widely spread taking into account cultural, philosophical, aesthetic, philosophical, anthropological, literary and other aspects. The generalization of research experience in this direction allows considering the development of multiculturalism concept from the encyclopaedic definition of the term to the philosophical and aesthetic meaning of this phenomenon.

The judge’s job is to achieve a delicate balance between the needs of the public and the rights of the individual. the duty of the judge is to protect the individual from abusive state action and to contribute to the meaning of citizenship and civic entitlement. While the central role of the judge in upholding the rule of law is simply stated, the methods by which this is achieved in our increasingly complex societies are changing and developing. To perform this task, the judiciary must remain independent of inthuence from other branches. this article seeks to analyze the judge’s role in detail at the trial level