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26 results on '"Tkachenko, Svyatoslav"'

8. Measurement of the generalized form factors near threshold via $\gamma^* p \to n\pi^+$ at high $Q^2$

Author

Park, Kijun, Gothe, Ralf, Adhikari, Krishna, Adikaram-Mudiyanselage, Dasuni, Anghinolfi, Marco, Baghdasaryan, Hovhannes, Ball, Jacques, Battaglieri, Marco, Baturin, Vitaly, Bedlinskiy, Ivan, Bennett, Robert, Biselli, Angela, Bookwalter, Craig, Boyarinov, Sergey, Branford, Derek, Briscoe, William, Brooks, William, Burkert, Volker, Carman, Daniel, Celentano, Andrea, Chandavar, Shloka, Charles, Gabriel, Cole, Philip, Contalbrigo, Marco, Crede, Volker, D'Angelo, Annalisa, Daniel, Aji, Dashyan, Natalya, De Vita, Raffaella, De Sanctis, Enzo, Deur, Alexandre, Djalali, Chaden, Doughty, David, Dupre, Raphael, Alaoui, Ahmed El, Elfassi, Lamiaa, Eugenio, Paul, Fedotov, Gleb, Fradi, Ahmed, Gabrielyan, Marianna, Gevorgyan, Nerses, Gilfoyle, Gerard, Giovanetti, Kevin, Girod, Francois-Xavier, Goetz, John, Gohn, Wesley, Golovach, Evgeny, Graham, Lewis, Griffioen, Keith, Guidal, Michel, Guo, Lei, Hafidi, Kawtar, Hakobyan, Hayk, Hanretty, Charles, Heddle, David, Hicks, Kenneth, Holtrop, Maurik, Ilieva, Yordanka, Ireland, David, Ishkhanov, Boris, Isupov, Evgeny, Jenkins, David, Jo, Hyon-Suk, Joo, Kyungseon, Khandaker, Mahbubul, Khetarpal, Puneet, Kim, Andrey, Kim, Wooyoung, Klein, Andreas, Klein, Franz, Kubarovsky, A., Kubarovsky, Valery, Kuhn, Sebastian, Kuleshov, Sergey, Kvaltine, Nicholas, Livingston, Kenneth, Lu, Haiyun, MacGregor, Ian, Markov, Nikolai, Mayer, Michael, McKinnon, Bryan, Mestayer, Mac, Meyer, Curtis, Mineeva, Taisiya, Mirazita, Marco, Mokeev, Viktor, Moutarde, Herve, Espitia, Edwin Munevar, Nadel-Turonski, Pawel, Nasseripour, Rakhsha, Niccolai, Silvia, Niculescu, Gabriel, Niculescu, Maria-Ioana, Osipenko, Mikhail, Ostrovidov, Alexander, Paolone, Michael, Pappalardo, Luciano, Paremuzyan, Rafayel, Park, Seungkyung, Pereira, Sergio, Phelps, Evan, Pisano, Silvia, Pogorelko, Oleg, Pozdnyakov, Sergey, Price, John, Procureur, Sebastien, Prok, Yelena, Ricco, Giovanni, Rimal, Dipak, Ripani, Marco, Ritchie, Barry, Rosner, Guenther, Rossi, Patrizia, Sabatie, Franck, Saini, Mukesh, Salgado, Carlos, Schott, Diane, Schumacher, Reinhard, Seraydaryan, Heghine, Sharabian, Youri, Smith, Elton, Smith, Gregory, Sober, Daniel, Sokhan, Daria, Stepanyan, Samuel, Stepanyan, Stepan, Stoler, Paul, Strakovski, Igor, Strauch, Steffen, Taiuti, Mauro, Tang, Wei, Taylor, Charles, Tian, Ye, Tkachenko, Svyatoslav, Trivedi, Arjun, Ungaro, Maurizio, Vernarsky, Brian, Vlasov, Alexander, Voutier, Eric, Watts, Daniel, Weygand, Dennis, Wood, Michael, Zachariou, Nicholas, Zhao, Bo, Zhao, Zhiwen, Kalantarians, N., and Hyde, C. E.

Subjects
Nuclear Experiment
Abstract

We report the first extraction of the pion-nucleon multipoles near the production threshold for the $n\pi^+$ channel at relatively high momentum transfer ($Q^2$ up to 4.2 $\rm{GeV^2}$). The dominance of the s-wave transverse multipole ($E_{0+}$), expected in this region, allowed us to access the generalized form factor $G_1$ within the light-cone sum rule (LCSR) framework as well as the axial form factor $G_A$. The data analyzed in this work were collected by the nearly $4\pi$ CEBAF Large Acceptance Spectrometer (CLAS) using a 5.754 $\rm{GeV}$ electron beam on a proton target. The differential cross section and the $\pi-N$-multipole $E_{0+}/G_D$ were measured using two different methods, the LCSR and a direct multipole fit. The results from the two methods are found to be consistent and almost $Q^2$ independent., Comment: 17pages, 22 figures, Journal article (Physical Review C)

Published
2012
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17. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy

Author

Harris, Alexandra R., Esparza, Savieay, Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., Munson, Jennifer M., Harris, Alexandra R., Esparza, Savieay, Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., and Munson, Jennifer M.

Abstract

Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence shows it can affect the tumor stroma, unintentionally promoting cancer malignancy. After treatment of primary tumors, remaining drugs drain via lymphatics. Though all drugs interact with the lymphatics, we know little of their impact on them. Here, we show a previously unknown effect of platinums, a widely used class of chemotherapeutics, to directly induce systemic lymphangiogenesis and activation. These changes are dose-dependent, long-lasting, and occur in healthy and cancerous tissue in multiple mouse models of breast cancer. We found similar effects in human ovarian and breast cancer patients whose treatment regimens included platinums. Carboplatin treatment of healthy mice prior to mammary tumor inoculation increased cancer metastasis as compared to no pre-treatment. These platinum-induced phenomena could be blocked by VEGFR3 inhibition. These findings have implications for cancer patients receiving platinums and may support the inclusion of anti-VEGFR3 therapy into treatment regimens or differential design of treatment regimens to alter these potential effects.

Published
2022

19. Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction

Author

Shin, Junchul, primary, Tkachenko, Svyatoslav, additional, Chaklader, Malay, additional, Pletz, Connor, additional, Singh, Kanwardeep, additional, Bulut, Gamze B, additional, Han, Young min, additional, Mitchell, Kelly, additional, Baylis, Richard A, additional, Kuzmin, Andrey A, additional, Hu, Bo, additional, Lathia, Justin D, additional, Stenina-Adognravi, Olga, additional, Podrez, Eugene, additional, Byzova, Tatiana V, additional, Owens, Gary K, additional, and Cherepanova, Olga A, additional

Published
2022
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20. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy

Author

Harris, Alexandra R., primary, Esparza, Savieay, additional, Azimi, Mohammad S., additional, Cornelison, Robert, additional, Azar, Francesca N., additional, Llaneza, Danielle C., additional, Belanger, Maura, additional, Mathew, Alexander, additional, Tkachenko, Svyatoslav, additional, Perez, Matthew J., additional, Rosean, Claire Buchta, additional, Bostic, Raegan R., additional, Cornelison, R. Chase, additional, Tate, Kinsley M., additional, Peirce-Cottler, Shayn M., additional, Paquette, Cherie, additional, Mills, Anne, additional, Landen, Charles N., additional, Saucerman, Jeff, additional, Dillon, Patrick M., additional, Pompano, Rebecca R., additional, Rutkowski, Melanie A., additional, and Munson, Jennifer M., additional

Published
2022
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22. Platinum chemotherapy induces lymphangiogenesis to prime tissues for tumor metastasis

Author

Harris, Alexandra R., Azimi, Mohammad S., Cornelison, Robert, Azar, Francesca N., Llaneza, Danielle C., Belanger, Maura, Mathew, Alexander, Tkachenko, Svyatoslav, Esparza, Savieay, Perez, Matthew J., Rosean, Claire Buchta, Bostic, Raegan R., Cornelison, R. Chase, Tate, Kinsley M., Peirce-Cottler, Shayn M., Paquette, Cherie, Mills, Anne, Landen, Charles N., Saucerman, Jeff, Dillon, Patrick M., Pompano, Rebecca R., Rutkowski, Melanie A., and Munson, Jennifer M.

Abstract

Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence shows it can affect the tumor stroma unintentionally promoting cancer malignancy. After treatment of primary tumors, remaining drug drains via lymphatics. Though all drugs interact with the lymphatics, we know little of their impact on them. Here, we show a previously unknown effect of platinums, a widely used chemotherapeutic, to directly induce systemic VEGFR3-dependent lymphangiogenesis. These changes are dose-dependent, long-lasting, and occur in healthy and cancerous tissue in multiple mouse models of breast cancer. We saw similar effects in human ovarian and breast cancer patients whose treatment regimens included platinums. Carboplatin treatment results in lymphatic hyperplasia and secretion of pro-chemotactic factors in lymph nodes. Carboplatin treatment of healthy mice prior to mammary tumor inoculation increases cancer metastasis. These findings have broad-reaching implications for cancer patients receiving platinums and support the inclusion of anti-VEGFR3 therapy into treatment regimens. Summary Platinum chemotherapy induces lymphangiogenesis priming tissues for metastasis of breast cancer. Inhibition of VEGFR3 via antibody blockade can reverse these effects.

Published
2019
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23. Platinum chemotherapy induces lymphangiogenesis in cancerous and healthy tissues that can be prevented with adjuvant anti-VEGFR3 therapy

Author

Harris, Alexandra R., primary, Esparza, Savieay, additional, Azimi, Mohammad S., additional, Cornelison, Robert, additional, Azar, Francesca N., additional, Llaneza, Danielle C., additional, Belanger, Maura, additional, Mathew, Alexander, additional, Tkachenko, Svyatoslav, additional, Perez, Matthew J., additional, Rosean, Claire Buchta, additional, Bostic, Raegan R., additional, Cornelison, R. Chase, additional, Tate, Kinsley M., additional, Peirce-Cottler, Shayn M., additional, Paquette, Cherie, additional, Mills, Anne, additional, Landen, Charles N., additional, Saucerman, Jeff, additional, Dillon, Patrick M., additional, Pompano, Rebecca R., additional, Rutkowski, Melanie A., additional, and Munson, Jennifer M., additional

Published
2019
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25. Measurement of ep->ep $\pi^0$ beam spin asymmetries above the resonance region

Author

Masi, Rita, Garcon, Michel, Zhao, Bo, Amaryan, Moscov, Amaryan, Moskov, Ambrozewicz, Pawel, Anghinolfi, Marco, Asryan, Gegham, Avagyan, Harutyun, Baghdasaryan, Hovhannes, Baillie, Nathan, Ball, J. P., Ball, Jacques, Ball, James, Baltzell, Nathan, Baturin, Vitaly, Battaglieri, Marco, Bedlinskiy, Ivan, Bellis, Matthew, Benmouna, Nawal, Berman, Barry, Bertin, Pierre, Biselli, Angela, Blaszczyk, Lukasz, Bouchigny, Sylvain, Boyarinov, Sergey, Bradford, Robert, Branford, Derek, Briscoe, William, Brooks, William, Bultmann, S., Bueltmann, Stephen, Burkert, Volker, Butuceanu, Cornel, Calarco, John, Careccia, Sharon, Carman, Daniel, Casey, Liam, Chen, Shifeng, Cheng, Lu, Cole, Philip, Collins, Patrick, Coltharp, Philip, Crabb, Donald, Crede, Volker, Dashyan, Natalya, Sanctis, Enzo, Vita, Raffaella, Degtiarenko, Pavel, Deur, Alexandre, Dharmawardane, Kahanawita, Dickson, Richard, Djalali, Chaden, Dodge, Gail, Donnelly, Joseph, Doughty, David, Dugger, Michael, Dzyubak, Oleksandr, Egiyan, Hovanes, Egiyan, Kim, Elfassi, Lamiaa, Elouadrhiri, Latifa, Eugenio, Paul, Fedotov, Gleb, Feldman, Gerald, Fradi, Ahmed, Funsten, Herbert, Gavalian, Gagik, Gilfoyle, Gerard, Giovanetti, Kevin, Girod, Francois-Xavier, Goetz, John, Gonenc, Atilla, Gothe, Ralf, Griffioen, Keith, Guidal, Michel, Guler, Nevzat, Guo, Lei, Gyurjyan, Vardan, Hafidi, Kawtar, Hakobyan, Hayk, Hanretty, Charles, Hersman, F., Hicks, Kenneth, Hleiqawi, Ishaq, Holtrop, Maurik, Hyde, Charles, Ilieva, Yordanka, Ireland, David, Ishkhanov, Boris, Isupov, Evgeny, Ito, Mark, Jenkins, David, Jo, Hyon-Suk, Johnstone, John, Joo, Kyungseon, Juengst, Henry, Kalantarians, Narbe, Kellie, James, Khandaker, Mahbubul, Kim, Wooyoung, Klein, Andreas, Klein, Franz, Klimenko, Alexei, Kossov, Mikhail, Krahn, Zebulun, Kramer, Laird, Kubarovsky, Valery, Kuhn, Joachim, Kuhn, Sebastian, Kuleshov, Sergey, Lachniet, Jeff, Laget, Jean, Langheinrich, Jorn, Lawrence, David, Lee, Tsung-Shung, Livingston, Kenneth, Lu, Haiyun, Maccormick, Marion, Markov, Nikolai, Mattione, Paul, Mazouz, Malek, Mckinnon, Bryan, Mecking, Bernhard, Mestayer, Mac, Meyer, Curtis, Mibe, Tsutomu, Michel, Bernard, Mikhaylov, Konstantin, Mirazita, Marco, Miskimen, Rory, Mokeev, Viktor, Moreno, Brahim, Moriya, Kei, Morrow, Steven, Moteabbed, Maryam, Munevar Espitia, Edwin, Mutchler, Gordon, Nadel-Turonski, Pawel, Nasseripour, Rakhsha, Niccolai, Silvia, Niculescu, Gabriel, Niculescu, Maria-Ioana, Niczyporuk, Bogdan, Niroula, Megh, Niyazov, Rustam, Nozar, Mina, Osipenko, Mikhail, Ostrovidov, Alexander, Park, Kijun, Pasyuk, Evgueni, Paterson, Craig, Pereira, Sergio, Pierce, Joshua, Pivnyuk, Nikolay, Pocanic, Dinko, Pogorelko, Oleg, Pozdnyakov, Sergey, Price, John, Procureur, Sebastien, Prok, Yelena, Protopopescu, Dan, Raue, Brian, Ricco, Giovanni, Ripani, Marco, Ritchie, Barry, Ronchetti, Federico, Rosner, Guenther, Rossi, Patrizia, Sabatie, Franck, Salamanca, Julian, Salgado, Carlos, Santoro, Joseph, Sapunenko, Vladimir, Schumacher, Reinhard, Serov, Vladimir, Sharabian, Youri, Sharov, Dmitri, Shvedunov, Nikolay, Smith, Elton, Smith, Lee, Sober, Daniel, Sokhan, Daria, Stavinsky, Aleksey, Stepanyan, Samuel, Stepanyan, Stepan, Stokes, Burnham, Stoler, Paul, Strakovski, Igor, Strauch, Steffen, Taiuti, Mauro, Tedeschi, David, Tkabladze, Avtandil, Tkachenko, Svyatoslav, Tur, Clarisse, Ungaro, Maurizio, Vineyard, Michael, Vlassov, Alexander, Voutier, Eric, Watts, Daniel, Weinstein, Lawrence, Weygand, Dennis, Williams, Michael, Wolin, Elliott, Wood, Michael, Yegneswaran, Amrit, Zana, Lorenzo, Zhang, Jixie, Zhiwen Zhao, Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), CLAS, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)

Subjects
12.40.Vv, 13.40.Gp, 13.60.Hb, 13.60.Le, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Nuclear Experiment
Abstract

5 pages, 6 figures; The beam spin asymmetry (BSA) in the exclusive reaction ep->ep pi0 was measured with the CEBAF 5.77 GeV polarized electron beam and Large Acceptance Spectrometer(CLAS). The xB, Q2, t and phi dependences of the pi0 BSA are presented in the deep inelastic regime. The asymmetries are fitted with a sin(phi) function and their amplitudes are extracted. Overall, they are of the order of 0.04 - 0.11 and roughly independent of t. This is the signature of a non-zero longitudinal-transverse interference. The implications concerning the applicability of a formalism based on generalized parton distributions, as well as the extension of a Regge formalism at high photon virtualities, are discussed.

Published
2008
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26. Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis.

Author

Zhevlakova I, Liu H, Dudiki T, Gao D, Yakubenko V, Tkachenko S, Cherepanova O, Podrez EA, and Byzova TV

Abstract

Aims: In the context of atherosclerosis, macrophages exposed to oxidized low-density lipoprotein (oxLDL) exhibit cellular abnormalities, specifically in adhesome functions, yet the mechanisms and implications of these adhesive dysfunctions remain largely unexplored., Methods and Results: This study reveals a significant depletion of Kindlin3 (K3) or Fermt3, an essential component of the adhesome regulating integrin functions, in macrophages located within atherosclerotic plaques in vivo and following oxLDL exposure in vitro. To examine the effects of K3 deficiency, the study utilized hyperlipidemic bone marrow chimeras devoid of myeloid Kindlin3 expression. Absence of myeloid K3 increased atherosclerotic plaque burden in the aortas in vivo and enhanced lipid accumulation and lipoprotein uptake in macrophages from Kindlin3-null chimeric mice in vitro. Importantly, re-expression of K3 in macrophages ameliorated these abnormalities.RNA sequencing of bone marrow-derived macrophages (BMDM) from K3-deficient mice revealed extensive deregulation in adhesion-related pathways, echoing changes observed in wild-type cells treated with oxLDL. Notably, there was an increase in Olr1 expression (encoding the Lectin-like oxidized LDL receptor-1 or LOX1), a gene implicated in atherogenesis. The disrupted K3-integrin axis in macrophages led to a significant elevation in the LOX1 receptor, contributing to increased oxLDL uptake and foam cell formation. Inhibition of LOX1 normalized lipid uptake in Kindlin3 null macrophages. A similar proatherogenic phenotype, marked by increased macrophage LOX1 expression and foam cell formation, was observed in myeloid-specific Itgβ1-deficient mice but not in Itgβ2-deficient mice, underscoring the critical role of K3/Itgβ1 interaction., Conclusion: This study shows that the loss of Kindlin3 in macrophages upon exposure to oxLDL leads to adhesome dysfunction in atherosclerosis and reveals the pivotal role of Kindlin3 in macrophage function and its contribution to the progression of atherosclerosis, providing valuable insights into the molecular mechanisms that could be targeted for therapeutic interventions., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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