Search

Your search keyword '"Tiwari, Satyam"' showing total 100 results
Start Over Author "Tiwari, Satyam"
100 results on '"Tiwari, Satyam"'

2. An Assessment of Available Node-Head Flow Relationships for Pressure Dependent Analysis of Water Distribution Networks

Author

Tiwari, Satyam, Sai Raj, K., Gupta, Rajesh, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Lu, Xinzheng, Series Editor, Pandey, Manish, editor, Jayakumar, K. V., editor, Pal, Manali, editor, and Singh, Vijay P., editor

Published
2025
Full Text
View/download PDF

12. Evaluation of Metal Removal Rate in EDM Machining of AISI P20 Steel

Author

Zafar, Tariq, Rawat, Shivam, Tiwari, Satyam, Singh, Abhishek, Shanu, Anurag, Vidya, Shrikant, Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, di Mare, Francesca, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, Singari, Ranganath M., editor, Kankar, Pavan Kumar, editor, and Moona, Girija, editor

Published
2022
Full Text
View/download PDF

13. Current Research Aspects and Trends in Electrical Discharge Machining: A Review

Author

Rawat, Shivam, Tiwari, Satyam, Zafar, Tariq, Singh, Abhishek, Shanu, Anurag, Vidya, Shrikant, Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, di Mare, Francesca, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, Singari, Ranganath M., editor, Kankar, Pavan Kumar, editor, and Moona, Girija, editor

Published
2022
Full Text
View/download PDF

17. Future of life in the Solar System and beyond

Author

Haqq-Misra, Jacob, primary, Gustafson, Kevin, additional, Tiwari, Satyam, additional, Yazıcı, Ayşe Meriç, additional, Profitiliotis, George, additional, Carneiro, Jéssica, additional, and Herts, Richard, additional

Published
2022
Full Text
View/download PDF

18. Contributors

Author

Benardini, J. Nick, primary, Berea, Anamaria, additional, Camprubi, Eloi, additional, Candian, Alessandra, additional, Carneiro, Jéssica, additional, Chan, Queenie Hoi Shan, additional, Cleaves, H. James, additional, Cockell, Charles S., additional, Ditzler, Mark Adam, additional, Dixit, J., additional, Gustafson, Kevin, additional, Haqq-Misra, Jacob, additional, Herts, Richard, additional, Jagtap, S.S., additional, Kaur, K., additional, Lee, Michael D., additional, Lin, Ying, additional, Liu, Rongrong, additional, Markovitch, Omer, additional, Marlow, Jeffrey, additional, McKay, Christopher P., additional, Méndez, Abel, additional, Moissl-Eichinger, Christine, additional, Muchowska, Kamila B., additional, Otto, Sijbren, additional, Perl, Scott M., additional, Petrignani, Annemieke, additional, Popović, Milena, additional, Profitiliotis, George, additional, Santiago, Ma. Francesca, additional, Seyler, Lauren M., additional, ten Kate, Inge Loes, additional, Thombre, R.S., additional, Tiwari, Satyam, additional, Vaishampayan, P.V., additional, Yazıcı, Ayşe Meriç, additional, Zajkowski, Tomasz, additional, and Zolensky, Michael E., additional

Published
2022
Full Text
View/download PDF

19. Economic Load Dispatch Using PSO

Author

Tiwari, Satyam, Pal, Nidhi Singh, Ansari, M. A., Yadav, Dilip, Singh, Nivedita, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Sharma, Devendra Kumar, editor, Balas, Valentina Emilia, editor, Son, Le Hoang, editor, Sharma, Rohit, editor, and Cengiz, Korhan, editor

Published
2020
Full Text
View/download PDF

30. Biological perspectives in geotechnics: Application and monitoring

Author

Mishra, Partha Narayan, primary, Jain, Surabhi, additional, Bore, Thierry, additional, Chang, Ilhan, additional, Kwon, Yeong-Man, additional, Wang, Yijie, additional, Dash, Hirak Ranjan, additional, Kumar, Ashutosh, additional, Tiwari, Satyam, additional, Jiang, Ningjun, additional, Das, Sarat Kumar, additional, and Scheuermann, Alexander, additional

Published
2023
Full Text
View/download PDF

41. Repair or Degrade: the Thermodynamic Dilemma of Cellular Protein Quality-Control

Author

Fauvet, Bruno, Rebeaud, Mathieu E., Tiwari, Satyam, De Los Rios, Paolo, Goloubinoff, Pierre, Fauvet, Bruno, Rebeaud, Mathieu E., Tiwari, Satyam, De Los Rios, Paolo, and Goloubinoff, Pierre

Abstract

Life is a non-equilibrium phenomenon. Owing to their high free energy content, the macromolecules of life tend to spontaneously react with ambient oxygen and water and turn into more stable inorganic molecules. A similar thermodynamic picture applies to the complex shapes of proteins: While a polypeptide is emerging unfolded from the ribosome, it may spontaneously acquire secondary structures and collapse into its functional native conformation. The spontaneity of this process is evidence that the free energy of the unstructured state is higher than that of the structured native state. Yet, under stress or because of mutations, complex polypeptides may fail to reach their native conformation and form instead thermodynamically stable aggregates devoid of biological activity. Cells have evolved molecular chaperones to actively counteract the misfolding of stress-labile proteins dictated by equilibrium thermodynamics. HSP60, HSP70 and HSP100 can inject energy from ATP hydrolysis into the forceful unfolding of stable misfolded structures in proteins and convert them into unstable intermediates that can collapse into the native state, even under conditions inauspicious for that state. Aggregates and misfolded proteins may also be forcefully unfolded and degraded by chaperone-gated endo-cellular proteases, and in eukaryotes also by chaperone-mediated autophagy, paving the way for their replacement by new, unaltered functional proteins. The greater energy cost of degrading and replacing a polypeptide, with respect to the cost of its chaperone-mediated repair represents a thermodynamic dilemma: some easily repairable proteins are better to be processed by chaperones, while it can be wasteful to uselessly try recover overly compromised molecules, which should instead be degraded and replaced. Evolution has solved this conundrum by creating a host of unfolding chaperones and degradation machines and by tuning their cellular amounts and activity rates.

Published
2021
Full Text
View/download PDF

50. Interdomain communication suppressing high intrinsic ATPase activity of Sse1 is essential for its co‐disaggregase activity with Ssa1.

Author

Kumar, Vignesh, Peter, Joshua Jebakumar, Sagar, Amin, Ray, Arjun, Jha, Mainak Pratim, Rebeaud, Mathieu E., Tiwari, Satyam, Goloubinoff, Pierre, Ashish, and Mapa, Koyeli

Subjects
NUCLEOTIDE exchange factors, SMALL-angle scattering, PROTEIN stability, MOLECULAR chaperones, CHIMERIC proteins
Abstract

In eukaryotes, Hsp110s are unambiguous cognates of the Hsp70 chaperones, in primary sequence, domain organization, and structure. Hsp110s function as nucleotide exchange factors (NEFs) for the Hsp70s although their apparent loss of Hsp70‐like chaperone activity, nature of interdomain communication, and breadth of domain functions are still puzzling. Here, by combining single‐molecule FRET, small angle X‐ray scattering measurements (SAXS), and MD simulation, we show that yeast Hsp110, Sse1 lacks canonical Hsp70‐like interdomain allostery. However, the protein exhibits unique noncanonical conformational changes within its domains. Sse1 maintains an open‐lid substrate‐binding domain (SBD) in close contact with its nucleotide‐binding domain (NBD), irrespective of its ATP hydrolysis status. To further appreciate such ATP‐hydrolysis‐independent exhaustive interaction between two domains of Hsp110s, NBD‐SBD chimera was constructed between Hsp110 (Sse1) and Hsp70 (Ssa1). In Sse1/Ssa1 chimera, we observed undocking of two domains leading to complete loss of NEF activity of Sse1. Interestingly, chimeric proteins exhibited significantly enhanced ATPase rate of Sse1‐NBD compared to wild‐type protein, implying that intrinsic ATPase activity of the protein remains mostly repressed. Apart from repressing the high ATPase activity of its NBD, interactions between two domains confer thermal stability to Sse1 and play critical role in the (co)chaperoning function of Sse1 in Ssa1‐mediated disaggregation activity. Altogether, Sse1 exhibits a unique interdomain interaction, which is essential for its NEF activity, suppression of high intrinsic ATPase activity, co‐chaperoning activity in disaggregase machinery, and stability of the protein. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results