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17 results on '"Tiwari, Amrendra K."'

3. Synchronized Codelivery of Combination Chemotherapies Intratumorally Using a Lipidic Lyotropic Liquid Crystal System

Author

Saklani, Ravi, primary, Yadav, Pavan K., additional, Tiwari, Amrendra K, additional, Gawali, Santosh L., additional, Hassan, Puthusserickal A., additional, Yadav, Karan, additional, Mugale, Madhav N., additional, Kalleti, Navodayam, additional, Rath, Srikanta K., additional, Mishra, Durga P., additional, Dierking, Ingo, additional, and Chourasia, Manish K., additional

Published
2024
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4. Magnetic nanoparticles

Author

Tiwari, Amrendra K., primary, Yadav, Pavan K., additional, Mishra, Keerti, additional, Singh, Pankaj Kumar, additional, and Chourasia, Manish K., additional

Published
2022
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5. Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications.

Author

Yadav, Pavan K, Verma, Saurabh, Chauhan, Divya, Yadav, Pooja, Tiwari, Amrendra K, Saklani, Ravi, Gupta, Deepak, Rana, Rafquat, Shah, Aarti Abhishek, Verma, Sonia, Naresh, Kothuri, Gayen, Jiaur R, and Chourasia, Manish K

Abstract

Aim & Objective: This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy. Materials & Methods: The nanoformulation was optimized via Box-Behnken Design (BBD), with method validation adhering to US-FDA guidelines. Results: Multiple reaction monitoring transitions for PTX, BTZ and internal standard were m/z 855.80→286.60, 366.80→226.00 and 179.80→110.00, respectively. Elution done on C18 Luna column with 0.1% FA in MeOH:10 mM ammonium acetate. The size of nanoformulation was 133.9 ± 1.97 nm, PDI 0.19 ± 0.01 and zeta potential -19.20 ± 1.36 mV. Pharmacokinetics showed higher Cmax for PTX-BTZ-NE (313.75 ± 10.71 ng/ml PTX, 11.92 ± 0.53 ng/ml BTZ) versus free PTX-BTZ (104 ± 13.06 ng/ml PTX, 1.9 ± 0.08 ng/ml BTZ). Conclusion: Future findings will contribute to the treatment of breast cancer using PTX and BTZ. Graphical Abstract Article highlights The importance of paclitaxel (PTX) and bortezomib (BTZ) in combination with chemotherapy is demonstrated by recently published studies. An obstacle to measuring the results of translational research is the lack of an analytical or bioanalytical approach for simultaneously estimating PTX and BTZ. A gap in the scientific literature has been filled by the development and validation of an LC-MS/MS method for the co-estimation or simultaneous measurement of PTX and BTZ. Both moieties were resolved in a Phenomenex Luna (C18), (7.5 × 4.6 mm, 3μ) column with a 0.1% FA in MeOH:10 mM ammonium acetate, 80:20 (% v/v) mobile phase at 0.6 ml/min flow rate. According to the US-FDA, the developed method was validated in female Sprague–Dawley rats plasma for different characteristics, such as linearity, precision and accuracy, LLOQ and stability studies. The oral P.K profile of PTX and BTZ co-loaded in a nanoformulation has been investigated in young female Sprague–Dawley rats to support the applicability of the established LC-MS/MS methodology. With an LLOQ of 1.0 ng/ml for each drug and a run time of 6.0 min, the calibration curve was found linear for the 1–600 ng/ml concentration range. The proposed LC-MS/MS method was confirmed to be repeatable, precise and accurate. The developed LC-MS/MS method was successfully illustrated for the co-estimation or simultaneous estimation of both drugs in rat plasma to generate an oral P.K profile. US-FDA Guidance of Industry and Bioanalytical Method Validation criteria was followed for the co-estimation of PTX and BTZ and was applied to nanoformulation development and bioanalytical investigations. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Enhanced apoptosis and mitochondrial cell death by paclitaxel-loaded TPP-TPGS1000-functionalized nanoemulsion

Author

Yadav, Pavan K, primary, Saklani, Ravi, additional, Tiwari, Amrendra K, additional, Verma, Saurabh, additional, Rana, Rafquat, additional, Chauhan, Divya, additional, Yadav, Pooja, additional, Mishra, Keerti, additional, Kedar, Ashwini S, additional, Kalleti, Navodayam, additional, Gayen, Jiaur R, additional, Wahajuddin, Muhammad, additional, Rath, Srikanta K, additional, Mugale, Madhav N, additional, Mitra, Kalyan, additional, Sharma, Deepak, additional, and Chourasia, Manish K, additional

Published
2023
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10. List of contributors

Author

Abutwaibe, K.A., Ayub, Anjuman, Bajhal, Sakshi, Batra, Sonali, Behera, Chittaranjan, Bhardwaj, Aditya Rattan, Bhattacharya, Diotima, Bosio, Gabriela N., Cabrera-Munguía, Denis A., Cai, Yu, Cancino-Bernardi, Juliana, Castillo-Rivera, F., Chavan, Sachin Ganpat, Chen, Haolin, Chopra, Chirag, Chourasia, Manish K., Claudio-Rizo, Jesús A., Costa, Clara Cardoso, de Camargo Tardio, Amanda, Dhanjal, Daljeet Singh, Díaz, Sandra Mendoza, Díaz-López, O., Dong, Xiaochen, Gao, Fan, Gupta, Prem N., Han, Hyo-Won, Jadav, Mahima, Jang, Eue-Soon, Javaid, Aaqib, Joe, Ara, Kakkar, Vandita, Kaur, Amanpreet, Koyappayil, Aneesh, Kulhari, Hitesh, Kumar, Lalit, Kumari, Parina, Kumari, Parveen, Laura Denise, Lopez-Barrera, Lee, Min-Ho, León-Campos, Maria I., Leung, Franco King-Chi, Li, Fang, Liang, Chen, Liu, Zhiming, López-Romero, José Mauricio, Maddheshiya, Shilpa, Manivasagan, Panchanathan, Manzano-Ramírez, Alejandro, Margatho, Júlia Mendonça, Marisetti, Arya Lakshmi, Mártire, Daniel O., Mendez, Nestor Efren, Mendoza-Villafaña, Juan J., Meza-Pardo, I.G., Mishra, Keerti, Mudavath, Shyam Lal, Mujahid, Haroon, Mujahid, Khizra, Nam, Jutaek, Nara, Seema, Nehru, Sangamithra, P, Prasanth, Patricia, Ramirez-Noguera, Ponpandian, Nagamony, Pooja, Deep, Rai, Divya Bharti, Ramamoorthy, Sharmiladevi, Rana, Isra, Rana, Rafquat, Ren, Yikun, Rivas Aiello, María Belén, Roberto, Diaz-Torres, Salado-Leza, D., Sánchez-Campos, D., Sandha, Kamalpreet Kaur, Sanu, Kumar, Saravanan, Nishakavya, Sawhney, Girish, Seo, Sun-Hwa, Sharma, Sumit, Singh, Manisha, Singh, Munendra, Singh, Reena, Sivaselvam, S., Soto, Karen, Suliman, Ivan Hardianto, Suman, Shikha, Sundaramurthy, Anandhakumar, Tewari, Devesh, Tiwari, Amrendra K., Toldo, Gustavo Silveira, Tripathi, Shourya, Veena, Mounasamy, Venkatesan, Jayachandran, Wani, Atif Khurshid, Wong, Wai-Ki, Xin, Junbo, Xu, Bo, Yadav, Pavan K., and Yadav, Pooja

Published
2025
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13. Enhanced apoptosis and mitochondrial cell death by paclitaxel-loaded TPP-TPGS1000-functionalized nanoemulsion.

Author

Yadav, Pavan K, Saklani, Ravi, Tiwari, Amrendra K, Verma, Saurabh, Rana, Rafquat, Chauhan, Divya, Yadav, Pooja, Mishra, Keerti, Kedar, Ashwini S, Kalleti, Navodayam, Gayen, Jiaur R, Wahajuddin, Muhammad, Rath, Srikanta K, Mugale, Madhav N, Mitra, Kalyan, Sharma, Deepak, and Chourasia, Manish K

Abstract

Background: The present research was designed to develop a nanoemulsion (NE) of triphenylphosphine-D-α-tocopheryl-polyethylene glycol succinate (TPP-TPGS1000) and paclitaxel (PTX) to effectively deliver PTX to improve breast cancer therapy. Materials & methods: A quality-by-design approach was applied for optimization and in vitro and in vivo characterization were performed. Results: The TPP-TPGS1000-PTX-NE enhanced cellular uptake, mitochondrial membrane depolarization and G2M cell cycle arrest compared with free-PTX treatment. In addition, pharmacokinetics, biodistribution and in vivo live imaging studies in tumor-bearing mice showed that TPP-TPGS1000-PTX-NE had superior performance compared with free-PTX treatment. Histological and survival investigations ascertained the nontoxicity of the nanoformulation, suggesting new opportunities and potential to treat breast cancer. Conclusion: TPP-TPGS1000-PTX-NE improved the efficacy of breast cancer treatment by enhancing its effectiveness and decreasing drug toxicity. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Contributors

Author

Adler, Anna, Agrawal, Mukta, Al-Jamal, Wafa’ T., Alexander, Amit, Amrahli, M., Antimisiaris, Sophia G., Aroffu, Matteo, Benival, Derajram, Berger, Manon, Bhilare, Neha V., Bonaccorso, Angela, Campani, Virginia, Carbone, Claudia, Castangia, Ines, Chakradhar, J.V.U.S., Chaurasiya, Akash, Cheung, Calvin C.L., Chourasia, Manish K., Cressey, P., Dallas, Paraskevas P., Delma, Kouka Luc, De Rosa, Giuseppe, Ebert, Roland, Ekdahl, Kristina N., Evrard, Brigitte, Fatouros, Dimitrios G., Fromell, Karin, Fulgheri, Federica, Giannopoulos-Dimitriou, Alexandros, Gkartziou, Foteini, Gupta, Raghav, Hemmingsen, Lisa Myrseth, Kannavou, Maria, Kelley, Elizabeth G., Kiranraj, G., Kommineni, Nagavendra, Liu, Xiaoyan, Logigan, Corina L., Ma, Xuejiao, Manca, Maria Letizia, Metsiou, Despoina Nektaria, Mineart, Kenneth P., Mishra, Keerti, Missirlis, Athanassios, Mouzoura, Panagiota, Musumeci, Teresa, Naredla, Manusri, Natsaridis, Evangelos, Nele, Valeria, Nilsson, Bo, Osmani, Riyaz Ali M., Paramshetti, Sharanya, Patel, Pranav, Patravale, Vandana, Penoy, Noémie, Peptu, Cristian, Peptu, Catalina A., Perra, Matteo, Petrou, Anthi, Piel, Géraldine, Pippa, Natassa, Rana, Dhwani, Rekkas, Dimitrios M., Saiti, Aikaterini, Sakai-Kato, Kumiko, Salave, Sagar, Singh, Snigdha, Singh, Ekta, Sofou, Stavroula, Stuart, Marc C.A., Suzuki, Haruna, Teramura, Yuji, Thanou, M., Tiwari, Amrendra K., Škalko-Basnet, Nataša, Verma, Sonia, Vizirianakis, Ioannis S., Wang, Ning, Wang, Ting, Yadav, Pooja, and Yadav, Pavan K.

Published
2024
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16. Contributors

Author

Agrawal, Aashruti, Ahmad, Farhan Jalees, Ali, Faria, Alka, Aqil, Mohd., Babu, M. Arockia, Banala, Venkatesh Teja, Beg, Sarwar, Bhat, Aditi, Bhavana, Valamla, Chary, Padakanti Sandeep, Chaudhary, Vikas, Chaurasiya, Akash, Chourasia, Manish K., Dalvi, Harshita, Fu, Yige, Gorajiya, Amruta, Goyal, Mimansa, Gulati, Monica, Gupta, Vivek, Jain, Harsha, Jain, Dhara, Jain, Nitin, Joshi, Isha, Jyoti, Kiran, Kaur, Manpreet, Khan, Ayesha, Khatri, Dharmendra Kumar, Kumar, Parveen, Kush, Preeti, Lakhera, Praveen, Madan, Jitender, Mahajan, Srushti, Maji, Indrani, Maurya, Priyanka, Mehra, Neelesh Kumar, Misra, Charu, Mishra, Keerti, Mishra, Nidhi, Mukherjee, Dhrubojyoti, Mukker, Jatinder Kaur, Nirmal, Jayabalan, Nisha, Raquibun, Pal, Ravi Raj, Parvathaneni, Vineela, Patel, Ketan, Patki, Manali, Paul, Rakesh Kumar, Pingle, Purva, Prasad Singh, Ravi Shankar, Qadir, Abdul, Rajana, Naveen, Rawat, Manoj, Raza, Kaisar, Sainaga Jyothi, Vaskuri G.S., Saraf, Shubhini A., Saraswat, Aishwarya, Sardana, Satish, Sharma, Deep Shikha, Shubhra, Shukla, Snehal K., Singh, Neelu, Singh, Pankaj Kumar, Singh, Priya, Singh, Sachin Kumar, Singh, Samipta, Singh, Shashi Bala, Singh, Yuvraj, Sodhi, Rupinder Kaur, Sree, Veerabomma Haritha, Sriram, Anitha, Srivastava, Saurabh, Tiwari, Amrendra K., Vartak, Richa, Wadhwa, Sheetu, Wang, Xuechun, Yadav, Pavan K., and Zafar, Sobiya

Published
2022
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17. Enhanced apoptosis and mitochondrial cell death by paclitaxel-loaded TPP-TPGS 1000 -functionalized nanoemulsion.

Author

Yadav PK, Saklani R, Tiwari AK, Verma S, Rana R, Chauhan D, Yadav P, Mishra K, Kedar AS, Kalleti N, Gayen JR, Wahajuddin M, Rath SK, Mugale MN, Mitra K, Sharma D, and Chourasia MK

Subjects
Mice, Animals, Tissue Distribution, Apoptosis, Cell Line, Tumor, Polyethylene Glycols pharmacology, Paclitaxel pharmacology, Vitamin E pharmacology
Abstract

Background: The present research was designed to develop a nanoemulsion (NE) of triphenylphosphine-D-α-tocopheryl-polyethylene glycol succinate (TPP-TPGS 1000 ) and paclitaxel (PTX) to effectively deliver PTX to improve breast cancer therapy. Materials & methods: A quality-by-design approach was applied for optimization and in vitro and in vivo characterization were performed. Results: The TPP-TPGS 1000 -PTX-NE enhanced cellular uptake, mitochondrial membrane depolarization and G 2 M cell cycle arrest compared with free-PTX treatment. In addition, pharmacokinetics, biodistribution and  in vivo live imaging studies in tumor-bearing mice showed that TPP-TPGS 1000 -PTX-NE had superior performance compared with free-PTX treatment. Histological and survival investigations ascertained the nontoxicity of the nanoformulation, suggesting new opportunities and potential to treat breast cancer. Conclusion: TPP-TPGS 1000 -PTX-NE improved the efficacy of breast cancer treatment by enhancing its effectiveness and decreasing drug toxicity.

Published
2023
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