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Older adults with human immunodeficiency virus (HIV) have higher risks for early manifestations of age-related disabilities. The objective of this study was to compare HIV-positive and HIV-negative adults aged ≥50 years in relation to sociodemographic, behavioral, and geriatric characteristics. A case-control study was conducted with a >90% estimated statistical power. A total of 52 individuals living with HIV were matched by age, sex, and neighborhood of residence with 104 community controls. Age-related disabilities were assessed throughout a comprehensive geriatric assessment. Review of medical records and interviews were used to obtain behavioral and clinical covariates. No statistical differences on clinically significant age-related disabilities were found. However, multivariate regression analyses, controlling for education and income, revealed that behavioral (use of condom [odds ratio {OR}: 7.03; 95% confidence intervals {CI}: 2.80–7.65] and number of medical visits [OR: 1.25; 95%CI: 1.09–1.43]), along with faster gait speed (OR: 17.68; 95%CI: 2.55–122.85) and lower body and muscle mass indexes were independently associated with HIV (OR: .88; 95%CI: .79–.98 and OR: .72; 95%CI: .54–.97, respectively). In summary, results on age-related disabilities between groups could mean that public policies on HIV might be contributing to patients’ positive outcomes regardless of the effects of aging, albeit gait speed, body and muscle mass indexes were independently associated with HIV. Screenings for age-related disabilities in specialized HIV services are recommended.

Submitted by Almir Squinsani (almir.squinsani@unioeste.br) on 2020-09-01T17:19:47Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Joana_Titon_2020.pdf: 1913065 bytes, checksum: 059c91188f700274d4c38f6d45c17083 (MD5) Made available in DSpace on 2020-09-01T17:19:47Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Joana_Titon_2020.pdf: 1913065 bytes, checksum: 059c91188f700274d4c38f6d45c17083 (MD5) Previous issue date: 2020-06-18 Introduction: The human immunodeficiency virus (HIV) infection causes depletion of CD4 + T lymphocytes, as well as a telomere shortening of these cells and increase in inflammatory mediators. All these characteristics are also observed in aging. Chronically infected patients have symptoms that resemble geriatric syndromes (GS). There is a higher prevalence of GS in older people and there seems to be a tendency for early appearing of them in HIV patients. However, reviewing literature, we did not identify studies that evaluate more than one GS using the Comprehensive Geriatric Assessment (CGA), comparing people with and without HIV. The objective of this research was to assess the association between the presence of GS and exposure to HIV. Method: Case-control study conducted in 2019 in adults aged 50 years-old or more in a specialized HIV care service and in basic health units in Francisco Beltrão, Brazil. 52 HIV cases and 104 non-HIV controls matched for age, sex and neighborhood were evaluated. A sociodemographic questionnaire and validated CGA tests were applied. The Chisquare test with Yates continuity correction and the Mann-Whitney U test were used for statistical analysis. Results: The mean age of the sample (n=156) was 60 ± 7.8, with 61.5% being female. Cases used fewer medications (p=0.019), have lower abdominal circumference (p=