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2. Positive and negative survivor-specific psychosocial consequences of childhood cancer: the DCCSS-LATER 2 psycho-oncology study

Author

Maas, Anne, Maurice-Stam, Heleen, van der Aa-van Delden, Alied M., van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-Eibrink, Marry M., Janssens, Geert O., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A. B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C. M., van Gorp, Marloes, and Grootenhuis, Martha A.

Published
2024
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3. The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer: results of the DCCSS-LATER study

Author

Maas, Anne, Maurice-Stam, Heleen, Feijen, Lieke E.A.M., Teepen, Jop C., van der Aa-van Delden, Alied M., Streefkerk, Nina, van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-Eibrink, Marry M., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A. B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C. M., and Grootenhuis, Martha

Published
2024
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7. Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue

Author

Kemps, Paul G., Baelde, Hans J., Vorderman, Ruben H. P., Stelloo, Ellen, Swennenhuis, Joost F., Szuhai, Karoly, Lamers, Meindert H., Kenkhuis, Boyd, Al-Hussaini, Maysa, Briaire-de Bruijn, Inge H., Lam, Suk Wai, Bovée, Judith V. M. G., Cleven, Arjen H. G., Verdijk, Robert M., van Noesel, Carel J. M., van Dijk, Marijke R., Scheijde-Vermeulen, Marijn A., Bruggink, Annette H., van Laar, Jan A. M., de Vries, Andrica C. H., Tissing, Wim J. E., van den Bos, Cor, von Deimling, Andreas, van Wezel, Tom, van Halteren, Astrid G. S., and Hogendoorn, Pancras C. W.

Published
2024
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10. Self-reported outcomes on oral health and oral health-related quality of life in long-term childhood cancer survivors—A DCCSS-LATER 2 Study

Author

Stolze, Juliette, Raber-Durlacher, Judith E., Loonen, Jacqueline J., Teepen, Jop C., Ronckers, Cécile M., Tissing, Wim J. E., de Vries, Andrica C. H., Neggers, Sebastian J. C. M. M., Dulmen-den Broeder, Eline, Heuvel-Eibrink, Marry M., van der Pal, Helena J. H., Versluys, A. Birgitta, Heiden-van der Loo, Margriet, Louwerens, Marloes, Kremer, Leontien C. M., Bresters, Dorine, and Brand, Henk S.

Published
2023
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12. Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study

Author

van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J, Pluijm, Saskia M F, Kremer, Leontien C M, Ronckers, Cécile M, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Olsson, Daniel S, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Tissing, Wim J E, Neggers, Sebastian J C M M, and van den Heuvel-Eibrink, Marry M

Published
2023
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14. Psychosocial developmental milestones of young adult survivors of childhood cancer

Author

Maurice-Stam, Heleen, van Erp, Loes M. E., Maas, Anne, van Oers, Hedy A., Kremer, Leontien C. M., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., Beek, Laura R., de Vries, Andrica C. H., van den Heuvel-Eibrink, Marry M., Ronckers, Cécile M., Bresters, Dorine, Louwerens, Marloes, van der Heiden-van der Loo, Margriet, Huizinga, Gea A., and Grootenhuis, Martha A.

Published
2022
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16. Treatments affecting splenic function as a risk factor for valvular heart disease in Childhood Cancer Survivors: A DCCSS‐LATER study.

Author

Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen‐den Broeder, Eline, Tissing, Wim J. E., van den Heuvel‐Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden‐van der Loo, Margriet, Ronckers, Cécile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., and Feijen, E. A. M. Lieke

Published
2024
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17. Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS‐LATER Study.

Author

Maas, Anne, Maurice‐Stam, Heleen, Feijen, E. A. M, Teepen, Jop C., van der Aa‐van Delden, Alied M., Streefkerk, Nina, van Dulmen‐den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel‐Eibrink, Marry M., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A. B., van der Heiden‐van der Loo, Margriet, Kremer, Leontien C. M., and Grootenhuis, Martha

Subjects
PSYCHOSOCIAL functioning, CHILDHOOD cancer, PROTECTIVE factors, QUALITY of life, PSYCHOSOCIAL factors
Abstract

Objective: This study examines the association between psychosocial risk and protective factors and a wide range of psychosocial outcomes including emotional, social, cognitive, and physical domains in childhood cancer survivors (CCS). Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)‐LATER cohort (diagnosed 1963–2001) part 2 (age ≥ 18 years, diagnosed < 18 years, ≥ 5 years since diagnosis) completed questionnaires on psychosocial risk and protective factors (Benefit and Burden Scale, Illness Cognition Questionnaire, Rosenberg Self‐Esteem Scale, and Impact of Cancer Scale), and psychosocial outcomes (Hospital Anxiety and Depression Scale, Self‐Rating Scale for Post‐Traumatic Stress Disorder, TNO‐AZL Questionnaire for Adult Health‐Related Quality of Life, and Short Form‐36). Associations were assessed with regression analysis, adjusting for attained age, sex, number of health conditions, and time since diagnosis, while correcting for multiple testing (p < 0.004). Results: A total of 1382 CCS participated, all diagnosed ≥ 15 years ago. The mean age of participating CCS was 36 years, and 51% were female. Perceived benefit and burden, acceptance, and helplessness, self‐esteem and social support were associated with the psychosocial outcomes. In the models including all psychosocial factors, most associations with psychosocial outcomes were seen for self‐esteem (10×), and perceived burden (9×). Self‐esteem (all β ≤ 0.47) and perceived burden (all β ≤ 0.38) demonstrated strongest associations of medium/large size. Conclusions: Perceptions of childhood cancer, illness cognitions, self‐esteem, and social support play a role in explaining psychosocial functioning in CCS, outweighing the influence of socio‐demographic and medical variables. Addressing negative perceptions and reducing feelings of helplessness, while promoting acceptance, self‐esteem, and social support, could provide intervention targets for CCS who encounter psychosocial challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors

Author

de Baat, Esmée C, primary, Merkx, Remy, additional, Leerink, Jan M, additional, Boerhout, Coen, additional, van der Pal, Heleen J H, additional, van Dalen, Elvira C, additional, Loonen, Jacqueline, additional, Bresters, Dorine, additional, van Dulmen-den Broeder, Eline, additional, van der Heiden-van der Loo, Margriet, additional, van den Heuvel, Marry M, additional, Kok, Judith L, additional, Louwerens, Marloes, additional, Neggers, Sebastian J C M M, additional, Ronckers, Cecline M, additional, Teepen, Jop C, additional, Tissing, Wim J E, additional, de Vries, Andrica C, additional, Kapusta, Livia, additional, Kremer, Leontien C M, additional, Mavinkurve-Groothuis, Annelies M C, additional, Kok, Wouter E M, additional, and Feijen, Elizabeth A M, additional

Published
2024
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21. Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Anderson, Richard A, Barnbrock, Anke, Beck, Joern D, Bos, Annelies M E, Calaminus, Gabriele, Constine, Louis S, Demeestere, Isabelle, Denzer, Christian, Grabow, Desiree, di Iorgi, Natascia, Hoefgen, Holly R, Jahnukainen, Kirsi, Kaatsch, Peter, Kebudi, Rejin, Lambalk, Cornelis, Langer, Thorsten, Loonen, Jacqueline, Lorenzo, Armando, Meacham, Lillian R, Meissner, Andreas, Mitchell, Rod T, Nahata, Leena, Ranft, Andreas, Dinkelman-Smit, Marij, Stern, Catharyn, Stutz-Grunder, Eveline, Tournaye, Herman, van Dorp, Wendy, van Pelt, Ans M M, de Vries, Andrica, Yu, Richard, Mulder, Renée L, Font-Gonzalez, Anna, van Dulmen-den Broeder, Eline, Quinn, Gwendolyn P, Ginsberg, Jill P, Loeffen, Erik A H, Hudson, Melissa M, Burns, Karen C, van Santen, Hanneke M, Berger, Claire, Diesch, Tamara, Dirksen, Uta, Giwercman, Aleksander, Gracia, Clarisa, Hunter, Sarah E, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian J C M M, Peate, Michelle, Phillips, Bob, Reed, Damon R, Tinner, Eva Maria E, Byrne, Julianne, Veening, Margreet, van de Berg, Marleen, Verhaak, Chris M, Anazodo, Antoinette, Rodriguez-Wallberg, Kenny, van den Heuvel-Eibrink, Marry M, Asogwa, Ogechukwu A, Brownsdon, Alexandra, Wallace, W Hamish, Green, Daniel M, Skinner, Roderick, Haupt, Riccardo, Kenney, Lisa B, Levine, Jennifer, van de Wetering, Marianne D, Tissing, Wim J E, Paul, Norbert W, Kremer, Leontien C M, and Inthorn, Julia

Published
2021
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22. Fertility preservation for female patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Berger, Claire, Diesch, Tamara, Dirksen, Uta, Ginsberg, Jill, Giwercman, Aleksander, Grabow, Desiree, Gracia, Clarisa, Hunter, Sarah E, Inthorn, Julia, Kaatsch, Peter, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian JCMM, Paul, Norbert W, Peate, Michelle, Phillips, Bob, Reed, Damon R, Tinner, Eva Maria E, van den Berg, Marleen, Verhaak, Chris, Mulder, Renée L, Font-Gonzalez, Anna, Hudson, Melissa M, van Santen, Hanneke M, Loeffen, Erik A H, Burns, Karen C, Quinn, Gwendolyn P, van Dulmen-den Broeder, Eline, Byrne, Julianne, Haupt, Riccardo, Wallace, W Hamish, van den Heuvel-Eibrink, Marry M, Anazodo, Antoinette, Anderson, Richard A, Barnbrock, Anke, Beck, Joern D, Bos, Annelies M E, Demeestere, Isabelle, Denzer, Christian, Di Iorgi, Natascia, Hoefgen, Holly R, Kebudi, Rejin, Lambalk, Cornelis, Langer, Thorsten, Meacham, Lillian R, Rodriguez-Wallberg, Kenny, Stern, Catharyn, Stutz-Grunder, Eveline, van Dorp, Wendy, Veening, Margreet, Veldkamp, Saskia, van der Meulen, Eline, Constine, Louis S, Kenney, Lisa B, van de Wetering, Marianne D, Kremer, Leontien C M, Levine, Jennifer, and Tissing, Wim J E

Published
2021
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23. Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Berger, Claire, Diesch, Tamara, Giwercman, Aleksander, Grabow, Desiree, Gracia, Clarisa, Hunter, Sarah E, Inthorn, Julia, Kaatsch, Peter, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian JCMM, Paul, Norbert W, Peate, Michelle, Phillips, Bob, Quinn, Gwendolyn P, Reed, Damon R, Tinner, Eva Maria E, van den Berg, Marleen, Verhaak, Chris, Mulder, Renée L, Font-Gonzalez, Anna, Green, Daniel M, Loeffen, Erik A H, Hudson, Melissa M, Loonen, Jacqueline, Yu, Richard, Ginsberg, Jill P, Mitchell, Rod T, Byrne, Julianne, Skinner, Roderick, Anazodo, Antoinette, Constine, Louis S, de Vries, Andrica, Jahnukainen, Kirsi, Lorenzo, Armando, Meissner, Andreas, Nahata, Leena, Dinkelman-Smit, Marij, Tournaye, Herman, Haupt, Riccardo, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, van Pelt, Ans M M, Dirksen, Uta, den Hartogh, Jaap, van Dulmen-den Broeder, Eline, Wallace, W Hamish, Levine, Jennifer, Tissing, Wim J E, Kremer, Leontien C M, Kenney, Lisa B, and van de Wetering, Marianne D

Published
2021
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24. The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer:results of the DCCSS-LATER study

Author

Maas, Anne, Maurice-Stam, Heleen, Feijen, Lieke E. A. M., Teepen, Jop C., van der Aa-van Delden, Alied M., Streefkerk, Nina, van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-eibrink, Marry M., Ronckers, Cecile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A. B., van der van der Loo, Margriet, Kremer, Leontien C. M., Grootenhuis, Martha, Maas, Anne, Maurice-Stam, Heleen, Feijen, Lieke E. A. M., Teepen, Jop C., van der Aa-van Delden, Alied M., Streefkerk, Nina, van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-eibrink, Marry M., Ronckers, Cecile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A. B., van der van der Loo, Margriet, Kremer, Leontien C. M., and Grootenhuis, Martha

Abstract

Purpose: Investigate the association between presence, number and type of clinically relevant health conditions and a range of psychosocial outcomes (emotional, social, cognitive, physical) in survivors of childhood cancer (CCS). Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963–2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013–2014), and questionnaires on psychosocial outcomes (2017–2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004). Results: A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large. Conclusion and implications: Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.

Published
2024

25. Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE

Author

MS VPG/Gynaecologie, Cancer, Speerpunt, Zorg en O&O, Child Health, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S E, Robison, Leslie L, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J, de Vries, Andrica C H, Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C M, Brooke, Russell J, Wang, Fan, Baedke, Jessica L, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, Ness, Kirsten K, Hudson, Melissa M, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, PanCareLIFE Consortium, MS VPG/Gynaecologie, Cancer, Speerpunt, Zorg en O&O, Child Health, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S E, Robison, Leslie L, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J, de Vries, Andrica C H, Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C M, Brooke, Russell J, Wang, Fan, Baedke, Jessica L, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, Ness, Kirsten K, Hudson, Melissa M, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, and PanCareLIFE Consortium

Published
2024

26. Treatments affecting splenic function as a risk factor for valvular heart disease in Childhood Cancer Survivors:A DCCSS-LATER study

Author

Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., van den Heuvel-Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden-vander Loo, Margriet, Ronckers, Cecile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., Feijen, E. A. M. Lieke, Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., van den Heuvel-Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden-vander Loo, Margriet, Ronckers, Cecile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., and Feijen, E. A. M. Lieke

Abstract

PurposeSplenectomy might be a risk factor for valvular heart disease (VHD) in adult Hodgkin lymphoma survivors. As this risk is still unclear for childhood cancer survivors (CCS), the aim of this study is to evaluate the association between treatments affecting splenic function (splenectomy and radiotherapy involving the spleen) and VHD in CCS.MethodsCCS were enrolled from the DCCSS-LATER cohort, consisting of 6,165 five-year CCS diagnosed between 1963 and 2002. Symptomatic VHD, defined as symptoms combined with a diagnostic test indicating VHD, was assessed from questionnaires and validated using medical records. Differences in the cumulative incidence of VHD between CCS who received treatments affecting splenic function and CCS who did not were assessed using the Gray test. Risk factors were analyzed in a multivariable Cox proportional hazards model.ResultsThe study population consisted of 5,286 CCS, with a median follow-up of 22 years (5-50 years), of whom 59 (1.1%) had a splenectomy and 489 (9.2%) radiotherapy involving the spleen. VHD was present in 21 CCS (0.4%). The cumulative incidence of VHD at the age of 40 years was significantly higher in CCS who received treatments affecting splenic function (2.7%, 95% confidence interval (CI) 0.4%-4.9%) compared with CCS without (0.4%, 95% CI 0.1%-0.7%) (Gray's test, p = 0.003). Splenectomy was significantly associated with VHD in a multivariable analysis (hazard ratio 8.6, 95% CI 3.1-24.1).Conclusions and implicationsSplenectomy was associated with VHD. Future research is needed to determine if CCS who had a splenectomy as part of cancer treatment might benefit from screening for VHD.

Published
2024

27. Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study

Author

Bouwman, Eline, Penson, Adriaan, de Valk, Maud, van den Oever, Selina R., van der Pal, Helena J. H., van Dulmen‐den Broeder, Eline, Blijlevens, Nicole M. A., Bresters, Dorine, Feijen, Elizabeth A. M., van den Heuvel‐Eibrink, Marry M., van der Heiden‐van der Loo, Margriet, Michel, Gisela, Ronckers, Cécile M., Teepen, Jop C., Tissing, Wim J. E., Versluys, Birgitta A. B., Kremer, Leontien C. M., Pluijm, Saskia M. F., Loonen, Jacqueline J., Bouwman, Eline, Penson, Adriaan, de Valk, Maud, van den Oever, Selina R., van der Pal, Helena J. H., van Dulmen‐den Broeder, Eline, Blijlevens, Nicole M. A., Bresters, Dorine, Feijen, Elizabeth A. M., van den Heuvel‐Eibrink, Marry M., van der Heiden‐van der Loo, Margriet, Michel, Gisela, Ronckers, Cécile M., Teepen, Jop C., Tissing, Wim J. E., Versluys, Birgitta A. B., Kremer, Leontien C. M., Pluijm, Saskia M. F., and Loonen, Jacqueline J.

Abstract

Background The objective of this study was to examine the prevalence of unhealthy lifestyle behaviors, overweight, and obesity in Dutch childhood cancer survivors (CCSs) compared with sibling controls and the Dutch general population. Other aims were to assess associated factors of unhealthy lifestyle behaviors, overweight, and obesity and to identify subgroups of CCSs at risk for these unhealthy statuses. Methods The authors included 2253 CCSs and 906 siblings from the Dutch Childhood Cancer Survivor Study-Late Effects After Childhood Cancer cohort, part 1, and added data from the Dutch general population. Questionnaire data were collected on overweight and obesity (body mass index >25.0 kg/m2), meeting physical activity guidelines (>150 minutes per week of moderate or vigorous exercises), excessive alcohol consumption (>14 and >21 alcoholic consumptions per week for women and men, respectively), daily smoking, and monthly drug use. Multivariable logistic regression analyses and two-step cluster analyses were performed to examine sociodemographic-related, health-related, cancer-related, and treatment-related associated factors of unhealthy lifestyle behaviors and to identify subgroups of CCSs at risk for multiple unhealthy behaviors. Results CCSs more often did not meet physical activity guidelines than their siblings (30.0% vs. 19.3%; p < .001). Married as marital status, lower education level, nonstudent status, and comorbidities were common associated factors for a body mass index ≥25.0 kg/m2 and insufficient physical activity, whereas male sex and lower education were shared associated factors for excessive alcohol consumption, daily smoking, and monthly drug use. A subgroup of CCSs was identified as excessive alcohol consumers, daily smokers, and monthly drug users. Conclusions The current results emphasize the factors associated with unhealthy behaviors and the potential identification of CCSs who exhibit multiple unhealthy lifestyle b, + ID der Publikation: unilu_74706 + Sprache: Englisch + Letzte Aktualisierung: 2024-05-29 11:24:41

Published
2024

29. Pain monitoring app leads to less pain in children with cancer at home: Results of a randomized controlled trial.

Author

Simon, Julia D. H. P., Schepers, Sasja A., van Gorp, Marloes, Michiels, Erna M. C., Fiocco, Marta, Grootenhuis, Martha A., and Tissing, Wim J. E.

Subjects
CANCER pain, RANDOMIZED controlled trials, CHILDHOOD cancer, DUTCH people, MOBILE apps
Abstract

Background: The authors developed a pain monitoring app offering educational information, and real‐time health care professional feedback on clinically significant pain (>4 numeric rating scale [NRS]‐11) for children with cancer to reduce pain at home. Methods: This monocenter, nonblinded randomized controlled trial enrolled Dutch children (0–18 years old) receiving cancer treatment (≥3 months after diagnosis, ≥2 months treatment remaining). Children were randomly assigned to use the app or receive usual care (two parallel groups). We assessed whether use of the app yielded less clinically significant pain (aim 1) and whether it affected pain severity, duration, interference, pain management strategies, and parental emotional well‐being (aim 2). The app was also evaluated by families (aim 3). Results: A total of 94 children were randomized to use the app (15 drop‐outs), and 90 were to receive care as usual (11 drop‐outs). The app group (n = 79, mean age: 7.5 [5.1] years, 48% girls, 63% hemato‐oncology diagnosis) reported significantly less clinically significant pain compared to usual care (n = 79, mean age: 7.5 [5.4] years, 52% girls, 65% hemato‐oncology diagnosis) (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.198–0.734]) (aim 1), as well as significantly lower pain severity (β = –0.27; 95% CI, –0.407 to –0.142). No differences were found for duration, interference, or management strategies. Parents in the app group reported significantly less distress compared to usual care (β = –0.84; 95% CI, –1.61 to –0.03]) (aim 2). Families generally evaluated the app positively (aim 3). Conclusions: Use of the app resulted in less clinically significant pain at home. The exact working mechanisms of the app should be further elucidated. Use of a pain monitoring app with educational information on pain (management) and real‐time health care professional feedback reduced clinically significant pain in children with cancer at home. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Different subtypes of chronic fatigue in childhood cancer survivors: A DCCSS LATER study.

Author

Penson, Adriaan, Walraven, Iris, Bronkhorst, Ewald, Grootenhuis, Martha A., Maurice‐Stam, Heleen, Loo, Margriet van der Heiden‐van der, Tissing, Wim J. E., van der Pal, Helena J. H., de Vries, Andrica C. H., Bresters, Dorine, Ronckers, Cécile M., van den Heuvel‐Eibrink, Marry M., Neggers, Sebastian, Versluys, Birgitta A. B., Louwerens, Marloes, Pluijm, Saskia M. F., Blijlevens, Nicole, van Dulmen‐den Broeder, Eline, Kremer, Leontien C. M., and Knoop, Hans

Published
2024
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31. Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer

Author

Penson, Adriaan, van Deuren, Sylvia, Bronkhorst, Ewald, Keizer, Ellen, Heskes, Tom, Coenen, Marieke J. H., Rosmalen, Judith G. M., Tissing, Wim J. E., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-Eibrink, Marry M., Neggers, Sebastian, Versluys, Birgitta A. B., Louwerens, Marloes, van der Heiden-van der Loo, Margriet, Pluijm, Saskia M. F., Grootenhuis, Martha, Blijlevens, Nicole, Kremer, Leontien C. M., van Dulmen-den Broeder, Eline, Knoop, Hans, and Loonen, Jacqueline

Published
2021
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34. Reproductive outcomes and reproductive health care utilization among male survivors of childhood cancer: A DCCSS‐LATER study.

Author

Claessens, Joyce J. M., Penson, Adriaan, Bronkhorst, Ewald M., Kremer, Leontien C. M., van Dulmen‐den Broeder, Eline, van der Heiden‐van der Loo, Margriet, Tissing, Wim J. E., van der Pal, Helena J. H., Blijlevens, Nicole M. A., van den Heuvel‐Eibrink, Marry M., Versluys, A. Birgitta, Bresters, Dorine, Ronckers, Cécile M., Walraven, Iris, Beerendonk, Catharina C. M., and Loonen, Jacqueline J.

Subjects
MEDICAL care use, CHILDHOOD cancer, REPRODUCTIVE technology, REPRODUCTIVE health, CANCER survivors, REPRODUCTIVE health services, FERTILITY clinics, FERTILITY preservation
Abstract

Background: Treatment‐related gonadal dysfunction leading to fertility problems is a frequently encountered late effect in childhood cancer survivors (CCSs). This study evaluated reproductive outcomes and reproductive health care utilization among male CCSs compared with male siblings. Methods: A nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor LATER study part 1, a questionnaire and linkage study. A questionnaire addressing reproductive outcomes and reproductive health care was completed by 1317 male CCSs and 407 male siblings. A total of 491 CCSs and 185 siblings had a previous or current desire for children and were included in this study. Results: Fewer CCSs had biological children compared with siblings (65% vs. 88%; p <.001). The type of conception by men who fathered a child was comparable between CCSs and siblings (spontaneous conception of 90% of both groups; p =.86). The percentage of men who had consulted a reproductive specialist because of not siring a pregnancy was higher in CCSs compared with siblings (34% vs. 12%; p <.001). Following consultation, fewer CCSs underwent assisted reproductive techniques (ART) compared with siblings (41% vs. 77%; p =.001). After ART, fewer CCSs fathered a child compared with siblings (49% vs. 94%; p =.001). Conclusions: More male survivors consult a reproductive specialist, but fewer survivors undergo ART and father a child after ART compared with siblings. This insight is important for understanding potential problems faced by survivors regarding family planning and emphasizes the importance of collaboration between oncologists and reproductive specialists. This study showed that two‐thirds of male survivors of childhood cancer who had a desire for children fathered a biological child and that children of 90% of male survivors were conceived spontaneously. Compared with male siblings, more male survivors consulted a reproductive specialist because of not siring a pregnancy; however, both the application of and birth rates after assisted reproductive techniques in survivors were lower. [ABSTRACT FROM AUTHOR]

Published
2024
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36. The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study

Author

Houtman, Bente M., primary, Walraven, Iris, additional, de Grouw, Elke, additional, van der Maazen, Richard W. M., additional, Kremer, Leontien C. M., additional, van Dulmen-den Broeder, Eline, additional, van den Heuvel-Eibrink, Marry M., additional, Tissing, Wim J. E., additional, Bresters, Dorine, additional, van der Pal, Helena J. H., additional, de Vries, Andrica C. H., additional, Louwerens, Marloes, additional, van der Heiden-van der Loo, Margriet, additional, Neggers, Sebastian J. C., additional, Janssens, Geert O., additional, Blijlevens, Nicole M. A., additional, Lambeck, Annechien J. A., additional, Preijers, Frank, additional, and Loonen, Jacqueline J., additional

Published
2023
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37. Health-related quality of life and its determinants during and after treatment for paediatric acute lymphoblastic leukaemia: a national, prospective, longitudinal study in the Netherlands

Author

Schwartz, Emily R, primary, Rensen, Niki, additional, Steur, Lindsay M H, additional, Gemke, Reinoud, additional, van Eijkelenburg, Natasha K A, additional, van der Sluis, Inge M, additional, Dors, Natasja, additional, van den Bos, Cor, additional, Tissing, Wim J E, additional, Grootenhuis, Martha A, additional, Kaspers, Gertjan J L, additional, and Van Litsenburg, Raphaele R L, additional

Published
2023
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38. Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care

Author

Van Schaik, Jiska, primary, Schouten-van Meeteren, Antoinette Y N, additional, Vos-Kerkhof, Evelien, additional, Janssens, Geert O, additional, Porro, Giorgio L, additional, Fiocco, Marta, additional, Bakker, Boudewijn, additional, Tissing, Wim J E, additional, Hoving, Eelco W, additional, and Santen, Hanneke M. van, additional

Published
2023
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39. Psychosexual development, sexual functioning and sexual satisfaction in long‐term childhood cancer survivors: DCCSS‐LATER 2 sexuality substudy

Author

Priboi, Cristina, primary, van Gorp, Marloes, additional, Maurice‐Stam, Heleen, additional, Michel, Gisela, additional, Kremer, Leontien C. M., additional, Tissing, Wim J. E., additional, Loonen, Jacqueline J., additional, van der Pal, Helena J. H., additional, de Vries, Andrica C. H., additional, van den Heuvel‐Eibrink, Marry M., additional, Ronckers, Cécile M., additional, Bresters, Dorine, additional, Louwerens, Marloes, additional, Neggers, Sebastian J. C. C. M., additional, van der Heiden‐van der Loo, Margriet, additional, van Dulmen‐den Broeder, Eline, additional, and Grootenhuis, Martha, additional

Published
2023
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41. Pharmacokinetic investigations of isavuconazole in paediatric cancer patients show reduced exposure of isavuconazole after opening capsules for administration via a nasogastric tube.

Author

Bury, Didi, Wolfs, Tom F W, Heine, Rob ter, Muilwijk, Eline W, Elst, Kim C M van der, Tissing, Wim J E, and Brüggemann, Roger J M

Subjects
NASOENTERAL tubes, CHILD patients, CHILDHOOD cancer, DRUG dosage, CANCER patients, MONTE Carlo method
Abstract

Objectives To study the isavuconazole pharmacokinetics in a real-life paediatric cohort and confirm whether the isavuconazole exposures are within the adult exposure range. Furthermore, we are the first to describe unbound isavuconazole pharmacokinetics. Methods In this prospective, observational study, the isavuconazole dosing regimen was as follows (IV/oral/nasogastric tube): 5.4 mg/kg isavuconazole (maximum 200 mg/dose) three times daily on Days 1 and 2, followed by 5.4 mg/kg isavuconazole (maximum 200 mg/dose) once daily. At least one pharmacokinetic curve was assessed. Non-linear mixed effects modelling was used for analysis. Monte Carlo simulations were performed with the above mentioned maintenance dose for IV administrations and a weight band dosing regimen for oral/nasogastric tube administrations: I) <18 kg (100 mg daily); II) 18–37 kg (150 mg daily); III)>37 kg (200 mg daily). Results Seventeen paediatric patients with a median age of 9 years (range 1–17) and median weight of 26.0 kg (range 8.4–78.5) were evaluated. A two-compartment model describing linear pharmacokinetics of the unbound concentrations and saturable protein binding fitted the isavuconazole concentrations best. The absolute bioavailability of isavuconazole was 41.0% (95% CI: 32.4%–50.8%). The median (IQR) simulated exposures (AUC0–24h, SS) of the total isavuconazole concentrations after IV and oral/nasogastric tube administration were 87.7 mg·h/L (70.5–105.1) and 50.3 mg·h/L (39.0–62.4), respectively. The unbound isavuconazole fraction (unbound/total) ranged from 0.5% to 2.3%. Conclusions This study revealed low bioavailability after nasogastric tube administration with opened capsules. Isavuconazole exposures were in the expected range following IV administration. Total and unbound isavuconazole pharmacokinetics were reported with a 5-fold range in the unbound fraction. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Psychosexual development, sexual functioning and sexual satisfaction in long-term childhood cancer survivors: DCCSS-LATER 2 sexuality substudy

Author

Priboi, Cristina, van Gorp, Marloes, Maurice-Stam, Heleen, Michel, Gisela, Kremer, Leontien C. M., Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-Eibrink, Marry M., Ronckers, Cécile M., Bresters, Dorine, Louwerens, Marloes, Neggers, Sebastian J. C. C. M., van der Heiden-van der Loo, Margriet, van Dulmen-den Broeder, Eline, and Grootenhuis, Martha

Abstract

Objectives Childhood cancer may negatively impact childhood cancer survivors' (CCS) sexuality. However, this is an understudied research area. We aimed to describe the psychosexual development, sexual functioning and sexual satisfaction of CCS, and identify determinants for these outcomes. Secondarily, we compared the outcomes of a subsample of emerging adult CCS to the Dutch general population. Methods From the Dutch Childhood Cancer Survivor Study LATER cohort (diagnosed 1963?2001), 1912 CCS (18?71 years, 50.8% male) completed questions on sexuality, psychosocial development, body perception, mental and physical health. Multivariable linear regressions were used to identify determinants. Sexuality of CCS age 18?24 (N = 243) was compared to same-aged references using binomial tests and t-tests. Results One third of all CCS reported hindered sexuality due to childhood cancer, with insecure body the most often reported reason (44.8%). Older age at study, lower education, surviving central nervous system cancer, poorer mental health and negative body perception were identified as determinants for later sexual debut, worse sexual functioning and/or sexual satisfaction. CCS age 18?24 showed significantly less experience with kissing (p = 0.014), petting under clothes (p = 0.002), oral (p = 0.016) and anal sex (p = 0.032) when compared to references. No significant differences with references were found for sexual functioning and sexual satisfaction, neither among female CCS nor male CCS age 18?24. Conclusions Emerging adult CCS reported less experience with psychosexual development, but similar sexual functioning and sexual satisfaction compared to references. We identified determinants for sexuality, which could be integrated in clinical interventions for CCS at risk for reduced sexuality., + ID der Publikation: unilu_68954 + Sprache: Englisch + Letzte Aktualisierung: 2023-07-21 15:28:04

Published
2023
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46. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER): a cross-sectional study

Author

van Atteveld, Jenneke E, primary, de Winter, Demi T C, additional, Pluimakers, Vincent G, additional, Fiocco, Marta, additional, Nievelstein, Rutger A J, additional, Hobbelink, Monique G G, additional, Kremer, Leontien C M, additional, Grootenhuis, Martha A, additional, Maurice-Stam, Heleen, additional, Tissing, Wim J E, additional, de Vries, Andrica C H, additional, Loonen, Jacqueline J, additional, van Dulmen-den Broeder, Eline, additional, van der Pal, Helena J H, additional, Pluijm, Saskia M F, additional, van der Heiden-van der Loo, Margriet, additional, Versluijs, A Birgitta, additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, van Santen, Hanneke M, additional, Hoefer, Imo, additional, van den Berg, Sjoerd A A, additional, den Hartogh, Jaap, additional, Hoeijmakers, Jan H J, additional, Neggers, Sebastian J C M M, additional, and van den Heuvel-Eibrink, Marry M, additional

Published
2023
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47. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER):a cross-sectional study

Author

van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, van den Heuvel-Eibrink, Marry M, van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, and van den Heuvel-Eibrink, Marry M

Abstract

BACKGROUND: Childhood cancer survivors appear to be at increased risk of frailty and sarcopenia, but evidence on the occurrence of and high-risk groups for these aging phenotypes is scarce, especially in European survivors. The aim of this cross-sectional study was to assess the prevalence of and explore risk factors for pre-frailty, frailty, and sarcopenia in a national cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001.METHODS: Eligible individuals (alive at the time of study, living in the Netherlands, age 18-45 years, and had not previously declined to participate in a late-effects study) from the Dutch Childhood Cancer Survivor Study (DCCSS-LATER) cohort were invited to take part in this cross-sectional study. We defined pre-frailty and frailty according to modified Fried criteria, and sarcopenia according to the European Working Group on Sarcopenia in Older People 2 definition. Associations between these conditions and demographic and treatment-related as well as endocrine and lifestyle-related factors were estimated with two separate multivariable logistic regression models in survivors with any frailty measurement or complete sarcopenia measurements.FINDINGS: 3996 adult survivors of the DCCSS-LATER cohort were invited to participate in this cross-sectional study. 1993 non-participants were excluded due to lack of response or a decline to participate and 2003 (50·1%) childhood cancer survivors aged 18-45 years were included. 1114 (55·6%) participants had complete frailty measurements and 1472 (73·5%) participants had complete sarcopenia measurements. Mean age at participation was 33·1 years (SD 7·2). 1037 (51·8%) participants were male, 966 (48·2%) were female, and none were transgender. In survivors with complete frailty measurements or complete sarcopenia measurements, the percentage of pre-frailty was 20·3% (95% CI 18·0-22·7), frailty was 7·4% (6·0-9·0), and sarcopenia was 4·4% (3·5-5·6). In the models for pre-frai

Published
2023

48. Pharmacokinetic investigations of isavuconazole in paediatric cancer patients show reduced exposure of isavuconazole after opening capsules for administration via a nasogastric tube

Author

Infectiezieken, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Apotheek Klinische Farmacie, PMC Medisch specialisten, Bury, Didi, Wolfs, Tom F W, Ter Heine, Rob, Muilwijk, Eline W, van der Elst, Kim C M, Tissing, Wim J E, Brüggemann, Roger J M, Infectiezieken, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Apotheek Klinische Farmacie, PMC Medisch specialisten, Bury, Didi, Wolfs, Tom F W, Ter Heine, Rob, Muilwijk, Eline W, van der Elst, Kim C M, Tissing, Wim J E, and Brüggemann, Roger J M

Published
2023

49. The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study

Author

Zorg en O&O, Cancer, Child Health, Speerpunt, PMC Medisch specialisten, SCT patientenzorg, MS Radiotherapie, Houtman, Bente M, Walraven, Iris, de Grouw, Elke, van der Maazen, Richard W M, Kremer, Leontien C M, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M, Tissing, Wim J E, Bresters, Dorine, van der Pal, Helena J H, de Vries, Andrica C H, Louwerens, Marloes, van der Heiden-van der Loo, Margriet, Neggers, Sebastian J C, Janssens, Geert O, Blijlevens, Nicole M A, Lambeck, Annechien J A, Preijers, Frank, Loonen, Jacqueline J, Zorg en O&O, Cancer, Child Health, Speerpunt, PMC Medisch specialisten, SCT patientenzorg, MS Radiotherapie, Houtman, Bente M, Walraven, Iris, de Grouw, Elke, van der Maazen, Richard W M, Kremer, Leontien C M, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M, Tissing, Wim J E, Bresters, Dorine, van der Pal, Helena J H, de Vries, Andrica C H, Louwerens, Marloes, van der Heiden-van der Loo, Margriet, Neggers, Sebastian J C, Janssens, Geert O, Blijlevens, Nicole M A, Lambeck, Annechien J A, Preijers, Frank, and Loonen, Jacqueline J

Published
2023

50. Prognostic factors for multi-organ dysfunction in pediatric oncology patients admitted to the pediatric intensive care unit

Author

Arts-assistenten Kinderen, Intensive care patientenzorg, Child Health, Other research (not in main researchprogram), MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, Medische staf Anesthesiologie, Cancer, Circulatory Health, PMC Medisch specialisten, Soeteman, Marijn, Fiocco, Marta F, Nijman, Joppe, Bollen, Casper W, Marcelis, Maartje M, Kilsdonk, Ellen, Nieuwenhuis, Edward E S, Kappen, Teus H, Tissing, Wim J E, Wösten-van Asperen, Roelie M, Arts-assistenten Kinderen, Intensive care patientenzorg, Child Health, Other research (not in main researchprogram), MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, Medische staf Anesthesiologie, Cancer, Circulatory Health, PMC Medisch specialisten, Soeteman, Marijn, Fiocco, Marta F, Nijman, Joppe, Bollen, Casper W, Marcelis, Maartje M, Kilsdonk, Ellen, Nieuwenhuis, Edward E S, Kappen, Teus H, Tissing, Wim J E, and Wösten-van Asperen, Roelie M

Published
2023

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