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87 results on '"Tisi, S."'

1. Respiratory Symptoms Present When Assessed for the Summit Study, A Lung Cancer Screening Study

Author

Mullin, M.L., primary, Bhamani, A., additional, Verghese, P., additional, Prendecki, K.R., additional, Khaw, C., additional, Creamer, A., additional, Dickson, J.L., additional, Horst, C., additional, Tisi, S., additional, Hall, H., additional, Gyertson, K., additional, Hacker, A.-M., additional, Farrelly, L., additional, McCabe, J., additional, Hackshaw, A., additional, and Janes, S., additional

Published
2024
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2. The JCMT Gould Belt Survey: A First Look at the Auriga-California Molecular Cloud with SCUBA-2

Author

Broekhoven-Fiene, H., Matthews, B. C., Harvey, P., Kirk, H., Chen, M., Currie, M. J., Pattle, K., Lane, J., Buckle, J., Di Francesco, J., Drabek-Maunder, E., Johnstone, D., Berry, D. S., Fich, M., Hatchell, J., Jenness, T., Mottram, J. C., Nutter, D., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Hogerheijde, M. R., Ward-Thompson, D., Bastien, P., Bresnahan, D., Butner, H., Chrysostomou, A., Coude, S., Davis, C. J., Duarte-Cabral, A., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Moriarty-Schieven, G., Mowat, C., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Rumble, D., Sadavoy, S., Thomas, H., Tothill, N., Viti, S., White, G. J., Wilson, C. D., Wouterloot, J., Yates, J., and Zhu, M.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present 850 and 450 micron observations of the dense regions within the Auriga-California molecular cloud using SCUBA-2 as part of the JCMT Gould Belt Legacy Survey to identify candidate protostellar objects, measure the masses of their circumstellar material (disk and envelope), and compare the star formation to that in the Orion A molecular cloud. We identify 59 candidate protostars based on the presence of compact submillimeter emission, complementing these observations with existing Herschel/SPIRE maps. Of our candidate protostars, 24 are associated with young stellar objects (YSOs) in the Spitzer and Herschel/PACS catalogs of 166 and 60 YSOs, respectively (177 unique), confirming their protostellar nature. The remaining 35 candidate protostars are in regions, particularly around LkHalpha 101, where the background cloud emission is too bright to verify or rule out the presence of the compact 70 micron emission that is expected for a protostellar source. We keep these candidate protostars in our sample but note that they may indeed be prestellar in nature. Our observations are sensitive to the high end of the mass distribution in Auriga-Cal. We find that the disparity between the richness of infrared star forming objects in Orion A and the sparsity in Auriga-Cal extends to the submillimeter, suggesting that the relative star formation rates have not varied over the Class II lifetime and that Auriga-Cal will maintain a lower star formation efficiency., Comment: 39 pages (54 including the Appendix), 9 figures, 3 tables, in press in ApJ

Published
2018
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3. The JCMT Gould Belt Survey: Evidence for Dust Grain Evolution in Perseus Star-forming Clumps

Author

Chen, Michael Chun-Yuan, Di Francesco, J., Johnstone, D., Sadavoy, S., Hatchell, J., Mottram, J. C., Kirk, H., Buckle, J., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Jenness, T., Nutter, D., Pattle, K., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Hogerheijde, M. R., Ward-Thompson, D., Bastien, P., Bresnahan, D., Butner, H., Chrysostomou, A., Coude, S., Davis, C. J., Drabek-Maunder, E., Duarte-Cabral, A., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Matthews, B. C., Moriarty-Schieven, G., Mowat, C., Pezzuto, S., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Rumble, D., Schneider-Bontemps, N., Thomas, H., Tothill, N., Viti, S., White, G. J., Wouterloot, J., Yates, J., and Zhu, M.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

The dust emissivity spectral index, $\beta$, is a critical parameter for deriving the mass and temperature of star-forming structures, and consequently their gravitational stability. The $\beta$ value is dependent on various dust grain properties, such as size, porosity, and surface composition, and is expected to vary as dust grains evolve. Here we present $\beta$, dust temperature, and optical depth maps of the star-forming clumps in the Perseus Molecular Cloud determined from fitting SEDs to combined Herschel and JCMT observations in the 160 $\mu$m, 250 $\mu$m, 350 $\mu$m, 500 $\mu$m, and 850 $\mu$m bands. Most of the derived $\beta$, and dust temperature values fall within the ranges of 1.0 - 2.7 and 8 - 20 K, respectively. In Perseus, we find the $\beta$ distribution differs significantly from clump to clump, indicative of grain growth. Furthermore, we also see significant, localized $\beta$ variations within individual clumps and find low $\beta$ regions correlate with local temperature peaks, hinting at the possible origins of low $\beta$ grains. Throughout Perseus, we also see indications of heating from B stars and embedded protostars, as well evidence of outflows shaping the local landscape., Comment: Accepted to ApJ, 15 figures, 3 tables

Published
2016
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4. The JCMT Gould Belt Survey: Evidence for radiative heating and contamination in the W40 complex

Author

Rumble, D., Hatchell, J., Pattle, K., Kirk, H., Wilson, T., Buckle, J., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Jenness, T., Johnstone, D., Mottram, J. C., Nutter, D., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Walker-Smith, S., Di Francesco, J., Hogerheijde, M. R., Ward-Thompson, D., Bastien, P., Bresnahan, D., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Drabek-Maunder, E., Duarte-Cabral, A., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Matthews, B. C., Moriarty-Schieven, G., Mowat, C., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Sadavoy, S., Thomas, H., Tothill, N., Viti, S., White, G. J., Wouterloot, J., Yates, J., and Zhu, M.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present SCUBA-2 450{\mu}m and 850{\mu}m observations of the W40 complex in the Serpens-Aquila region as part of the James Clerk Maxwell Telescope (JCMT) Gould Belt Survey (GBS) of nearby star-forming regions. We investigate radiative heating by constructing temperature maps from the ratio of SCUBA-2 fluxes using a fixed dust opacity spectral index, {\beta} = 1.8, and a beam convolution kernel to achieve a common 14.8" resolution. We identify 82 clumps ranging between 10 and 36K with a mean temperature of 20{\pm}3K. Clump temperature is strongly correlated with proximity to the external OB association and there is no evidence that the embedded protostars significantly heat the dust. We identify 31 clumps that have cores with densities greater than 105cm{^{-3}}. Thirteen of these cores contain embedded Class 0/I protostars. Many cores are associated with bright-rimmed clouds seen in Herschel 70 {\mu}m images. From JCMT HARP observations of the 12CO 3-2 line, we find contamination of the 850{\mu}m band of up to 20 per cent. We investigate the free-free contribution to SCUBA-2 bands from large-scale and ultracompact H ii regions using archival VLA data and find the contribution is limited to individual stars, accounting for 9 per cent of flux per beam at 450 {\mu}m or 12 per cent at 850 {\mu}m in these cases. We conclude that radiative heating has potentially influenced the formation of stars in the Dust Arc sub-region, favouring Jeans stable clouds in the warm east and fragmentation in the cool west., Comment: 27 pages, 25 figures, 7 tables, 3 online catalogues

Published
2016
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5. The JCMT Gould Belt Survey: Dense Core Clusters in Orion B

Author

Kirk, H., Johnstone, D., Di Francesco, J., Lane, J., Buckle, J., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Hatchell, J., Jenness, T., Mottram, J. C., Nutter, D., Pattle, K., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Hogerheijde, M. R., and Ward-Thompson, D.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

The JCMT Gould Belt Legacy Survey obtained SCUBA-2 observations of dense cores within three sub-regions of Orion B: LDN 1622, NGC 2023/2024, and NGC 2068/2071, all of which contain clusters of cores. We present an analysis of the clustering properties of these cores, including the two-point correlation function and Cartwright's Q parameter. We identify individual clusters of dense cores across all three regions using a minimal spanning tree technique, and find that in each cluster, the most massive cores tend to be centrally located. We also apply the independent M-Sigma technique and find a strong correlation between core mass and the local surface density of cores. These two lines of evidence jointly suggest that some amount of mass segregation in clusters has happened already at the dense core stage., Comment: Accepted for publication in ApJ. 22 pages, 11 figures

Published
2016
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6. The JCMT Gould Belt Survey: A First Look at Dense Cores in Orion B

Author

Kirk, H., Di Francesco, J., Johnstone, D., Duarte-Cabral, A., Sadavoy, S., Hatchell, J., Mottram, J. C., Buckle, J., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Jenness, T., Nutter, D., Pattle, K., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Hogerheijde, M. R., Ward-Thompson, D., Bastien, P., Bresnahan, D., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Drabek-Maunder, E., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Matthews, B. C., Moriarty-Schieven, G., Mowat, C., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Rumble, D., Thomas, H., Tothill, N., Viti, S., White, G. J., Wouterloot, J., Yates, J., and Zhu, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

We present a first look at the SCUBA-2 observations of three sub-regions of the Orion B molecular cloud: LDN 1622, NGC 2023/2024, and NGC 2068/2071, from the JCMT Gould Belt Legacy Survey. We identify 29, 564, and 322 dense cores in L1622, NGC 2023/2024, and NGC 2068/2071 respectively, using the SCUBA-2 850 micron map, and present their basic properties, including their peak fluxes, total fluxes, and sizes, and an estimate of the corresponding 450 micron peak fluxes and total fluxes, using the FellWalker source extraction algorithm. Assuming a constant temperature of 20 K, the starless dense cores have a mass function similar to that found in previous dense core analyses, with a Salpeter-like slope at the high-mass end. The majority of cores appear stable to gravitational collapse when considering only thermal pressure; indeed, most of the cores which have masses above the thermal Jeans mass are already associated with at least one protostar. At higher cloud column densities, above 1-2 x 10^23 cm^-2, most of the mass is found within dense cores, while at lower cloud column densities, below 1 x 10^23 cm^-2, this fraction drops to 10% or lower. Overall, the fraction of dense cores associated with a protostar is quite small (<8%), but becomes larger for the densest and most centrally concentrated cores. NGC 2023 / 2024 and NGC 2068/2071 appear to be on the path to forming a significant number of stars in the future, while L1622 has little additional mass in dense cores to form many new stars., Comment: Accepted for publication in ApJ; 28 pages, 19 figures. Data associated with the paper, including the full table 4, can be found at https://doi.org/10.11570/16.0003

Published
2015
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7. The JCMT Gould Belt Survey: SCUBA-2 observations of circumstellar disks in L 1495

Author

Buckle, J. V., Drabek-Maunder, E., Greaves, J., Richer, J. S., Matthews, B. C., Johnstone, D., Kirk, H., Beaulieu, S. F., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Hatchell, J., Jenness, T., Mottram, J. C., Nutter, D., Pattle, K., Pineda, J. E., Salji, C., Tisi, S., Di Francesco, J., Hogerheijde, M. R., Ward-Thompson, D., Bastien, P., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Duarte-Cabral, A., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Moriarty-Schieven, G., Rawlings, J., Rosolowsky, E., Rumble, D., Sadavoy, S., Thomas, H., Tothill, N., Viti, S., White, G. J., Wilson, C. D., Wouterloot, J., Yates, J., and Zhu, M.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present 850$\mu$m and 450$\mu$m data from the JCMT Gould Belt Survey obtained with SCUBA-2 and characterise the dust attributes of Class I, Class II and Class III disk sources in L1495. We detect 23% of the sample at both wavelengths, with the detection rate decreasing through the Classes from I--III. The median disk mask is 1.6$\times 10^{-3}$M$_{\odot}$, and only 7% of Class II sources have disk masses larger than 20 Jupiter masses. We detect a higher proportion of disks towards sources with stellar hosts of spectral type K than spectral type M. Class II disks with single stellar hosts of spectral type K have higher masses than those of spectral type M, supporting the hypothesis that higher mass stars have more massive disks. Variations in disk masses calculated at the two wavelengths suggests there may be differences in dust opacity and/or dust temperature between disks with hosts of spectral types K to those with spectral type M., Comment: 11 pages, 10 figures plus Appendix. MNRAS accepted

Published
2015
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8. The JCMT Gould Belt Survey: First results from the SCUBA-2 observations of the Ophiuchus molecular cloud and a virial analysis of its prestellar core population

Author

Pattle, K., Ward-Thompson, D., Kirk, J. M., White, G. J., Drabek-Maunder, E., Buckle, J., Beaulieu, S. F., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Hatchell, J., Kirk, H., Jenness, T., Johnstone, D., Mottram, J. C., Nutter, D., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Walker-Smith, S., Di Francesco, J., Hogerheijde, M. R., André, Ph., Bastien, P., Bresnahan, D., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Duarte-Cabral, A., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Griffin, M. J., Holland, W., Joncas, G., Knee, L. B. G., Könyves, V., Mairs, S., Marsh, K., Matthews, B. C., Moriarty-Schieven, G., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Rumble, D., Sadavoy, S., Spinoglio, L., Thomas, H., Tothill, N., Viti, S., Wouterloot, J., Yates, J., and Zhu, M.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

In this paper we present the first observations of the Ophiuchus molecular cloud performed as part of the James Clerk Maxwell Telescope (JCMT) Gould Belt Survey (GBS) with the SCUBA-2 instrument. We demonstrate methods for combining these data with previous HARP CO, Herschel, and IRAM N$_{2}$H$^{+}$ observations in order to accurately quantify the properties of the SCUBA-2 sources in Ophiuchus. We produce a catalogue of all of the sources found by SCUBA-2. We separate these into protostars and starless cores. We list all of the starless cores and perform a full virial analysis, including external pressure. This is the first time that external pressure has been included in this level of detail. We find that the majority of our cores are either bound or virialised. Gravitational energy and external pressure are on average of a similar order of magnitude, but with some variation from region to region. We find that cores in the Oph A region are gravitationally bound prestellar cores, while cores in the Oph C and E regions are pressure-confined. We determine that N$_{2}$H$^{+}$ is a good tracer of the bound material of prestellar cores, although we find some evidence for N$_{2}$H$^{+}$ freeze-out at the very highest core densities. We find that non-thermal linewidths decrease substantially between the gas traced by C$^{18}$O and that traced by N$_{2}$H$^{+}$, indicating the dissipation of turbulence at higher densities. We find that the critical Bonnor-Ebert stability criterion is not a good indicator of the boundedness of our cores. We detect the pre-brown dwarf candidate Oph B-11 and find a flux density and mass consistent with previous work. We discuss regional variations in the nature of the cores and find further support for our previous hypothesis of a global evolutionary gradient across the cloud from southwest to northeast, indicating sequential star formation across the region., Comment: 34 pages, 20 figures, 5 tables. Accepted for publication in MNRAS

Published
2015
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9. The JCMT Gould Belt Survey: Evidence for radiative heating in Serpens MWC 297 and its influence on local star formation

Author

Rumble, D., Hatchell, J., Gutermuth, R. A., Kirk, H., Buckle, J., Beaulieu, S. F., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Jenness, T., Johnstone, D., Mottram, J. C., Nutter, D., Pattle, K., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Walker-Smith, S., Di Francesco, J., Hogerheijde, M. R., Ward-Thompson, D., Allen, L. E., Cieza, L. A., Dunham, M. M., Harvey, P. M., Stapelfeldt, K. R., Bastien, P., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Drabek-Maunder, E., Duarte-Cabral, A., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Matthews, B. C., Moriarty-Schieven, G., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Sadavoy, S., Thomas, H., Tothill, N., Viti, S., White, G. J., Wilson, C. D., Wouterloot, J., Yates, J., and Zhu, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present SCUBA-2 450micron and 850micron observations of the Serpens MWC 297 region, part of the JCMT Gould Belt Survey of nearby star-forming regions. Simulations suggest that radiative feedback influences the star-formation process and we investigate observational evidence for this by constructing temperature maps. Maps are derived from the ratio of SCUBA-2 fluxes and a two component model of the JCMT beam for a fixed dust opacity spectral index of beta = 1.8. Within 40 of the B1.5Ve Herbig star MWC 297, the submillimetre fluxes are contaminated by free-free emission with a spectral index of 1.03+-0.02, consistent with an ultra-compact HII region and polar winds/jets. Contamination accounts for 73+-5 per cent and 82+-4 per cent of peak flux at 450micron and 850micron respectively. The residual thermal disk of the star is almost undetectable at these wavelengths. Young Stellar Objects are confirmed where SCUBA-2 850micron clumps identified by the fellwalker algorithm coincide with Spitzer Gould Belt Survey detections. We identify 23 objects and use Tbol to classify nine YSOs with masses 0.09 to 5.1 Msun. We find two Class 0, one Class 0/I, three Class I and three Class II sources. The mean temperature is 15+-2K for the nine YSOs and 32+-4K for the 14 starless clumps. We observe a starless clump with an abnormally high mean temperature of 46+-2K and conclude that it is radiatively heated by the star MWC 297. Jeans stability provides evidence that radiative heating by the star MWC 297 may be suppressing clump collapse., Comment: 24 pages, 13 figures, 7 tables

Published
2014
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10. The origin of organic emission in NGC 2071

Author

van Kempen, T. A., McCoey, C., Tisi, S., Johnstone, D., and Fich, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

Context: The physical origin behind organic emission in embedded low-mass star formation has been fiercely debated in the last two decades. A multitude of scenarios have been proposed, from a hot corino to PDRs on cavity walls to shock excitation. Aims: The aim of this paper is to determine the location and the corresponding physical conditions of the gas responsible for organics emission lines. The outflows around the small protocluster NGC 2071 are an ideal testbed to differentiate between various scenarios. Methods: Using Herschel-HIFI and the SMA, observations of CH3OH, H2CO and CH3CN emission lines over a wide range of excitation energies were obtained. Comparisons to a grid of radiative transfer models provide constraints on the physical conditions. Comparison to H2O line shape is able to trace gas-phase synthesis versus a sputtered origin. Results: Emission of organics originates in three spots: the continuum sources IRS 1 ('B') and IRS 3 ('A') as well as a outflow position ('F'). Densities are above 10$^7$ cm$^{-3}$ and temperatures between 100 to 200 K. CH3OH emission observed with HIFI originates in all three regions and cannot be associated with a single region. Very little organic emission originates outside of these regions. Conclusions: Although the three regions are small (<1,500 AU), gas-phase organics likely originate from sputtering of ices due to outflow activity. The derived high densities (>10$^7$ cm$^{-3}$) are likely a requirement for organic molecules to survive from being destroyed by shock products. The lack of spatially extended emission confirms that organic molecules cannot (re)form through gas-phase synthesis, as opposed to H2O, which shows strong line wing emission. The lack of CH3CN emission at 'F' is evidence for a different history of ice processing due to the absence of a protostar at that location and recent ice mantle evaporation., Comment: 10 Pages, 8 figures, Accepted for Astronomy and Astrophysics

Published
2014
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11. The abundance of C18O and HDO in the envelope and hot core of the intermediate mass protostar NGC 7129 FIRS 2

Author

Fuente, A., Caselli, P., McCoey, C., Cernicharo, J., Johnstone, D., Fich, M., van Kempen, T., van Dishoeck, E., Yildiz, U., Visser, R., Kristensen, L., Alonso-Albi, T., Herpin, F., and Tisi, S.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

NGC 7129 FIRS 2 is a young intermediate-mass (IM) protostar, which is associated with two energetic bipolar outflows and displays clear signs of the presence of a hot core. It has been extensively observed with ground based telescopes and within the WISH Guaranteed Time Herschel Key Program. We present new observations of the C18O 3-2 and the HDO 3_{12}-2_{21} lines towards NGC 7129 FIRS 2. Combining these observations with Herschel data and modeling their emissions, we constrain the C18O and HDO abundance profiles across the protostellar envelope. In particular, we derive the abundance of C18O and HDO in the hot core. The intensities of the C18O lines are well reproduced assuming that the C18O abundance decreases through the protostellar envelope from the outer edge towards the centre until the point where the gas and dust reach the CO evaporation temperature (~20-25 K) where the C18O is released back to the gas phase. Once the C18O is released to the gas phase, the modelled C18O abundance is found to be ~1.6x10^{-8}, which is a factor of 10 lower than the reference abundance. This result is supported by the non-detection of C18O 9-8, which proves that even in the hot core (T_k>100 K) the CO abundance must be 10 times lower than the reference value. Several scenarios are discussed to explain this C18O deficiency. One possible explanation is that during the pre-stellar and protostellar phase, the CO is removed from the grain mantles by reactions to form more complex molecules. Our HDO modeling shows that the emission of HDO 3_{12}-2_{21} line is maser and comes from the hot core (T_k>100 K). Assuming the physical structure derived by Crimier et al. (2010), we determine a HDO abundance of ~0.4 - 1x10^{-7} in the hot core of this IM protostar, similar to that found in the hot corinos NGC 1333 IRAS 2A and IRAS 16293-2422., Comment: 10 pages, 7 figures

Published
2012
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12. Prevalence and demographics of marijuana users in a Lung Cancer Screening cohort

Author

Bhamani, A, primary, Dickson, J L, additional, Horst, C, additional, Tisi, S, additional, Hall, H, additional, Creamer, A, additional, Prendecki, R, additional, Mccabe, J, additional, Quaife, S L, additional, Bojang, F, additional, Arancon, D, additional, Gyertson, K, additional, Mullin, A, additional, Teague, J, additional, Farrelly, L, additional, Hackshaw, A, additional, and Janes, S M, additional

Published
2022
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14. P100 Impact of the COVID-19 pandemic on health services utilisation in a lung cancer screening cohort

Author

Creamer, AW, primary, Dickson, J, additional, Horst, C, additional, Tisi, S, additional, Hall, H, additional, Verghese, P, additional, Prendecki, R, additional, McCabe, J, additional, Phua, K, additional, Mehta, S, additional, Gyertson, K, additional, Mullin, AM, additional, Teague, J, additional, Farrelly, L, additional, Hackshaw, A, additional, and Janes, S, additional

Published
2021
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15. SUMMIT Study: Quality of Spirometry Performed as Part of a ‘Lung Health Check’ (LHC) Assessment for Inclusion into Low Dose Computed Tomography (LDCT) Lung Cancer Screening (LCS)

Author

Tisi, S., primary, Dickson, J.L., additional, Horst, C., additional, Hall, H., additional, Verghese, P., additional, Creamer, A., additional, Mullin, A.-M., additional, Sarpong, R., additional, Teague, J., additional, Farrelly, L., additional, Gyertson, K., additional, Bowyer, V., additional, Levermore, C., additional, Hackshaw, A., additional, Hurst, J., additional, and Janes, S., additional

Published
2021
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16. P41.04 The SUMMIT Study: Pulmonary Nodule and Incidental Findings in the First 10,000 Participants of a Population-Based Low-Dose CT Screening Study

Author

Horst, C., primary, Dickson, J., additional, Tisi, S., additional, Hall, H., additional, Verghese, P., additional, Mullin, A., additional, Farrelly, L., additional, Levermore, C., additional, Gyertson, K., additional, Clarke, C., additional, Allen, B., additional, Hamilton, S., additional, Hartman, A., additional, Nair, A., additional, Devaraj, A., additional, Hackshaw, A., additional, and Janes, S., additional

Published
2021
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17. P18 The SUMMIT study: uptake from re-invitation

Author

Dickson, JL, primary, Quaife, SL, additional, Horst, C, additional, Tisi, S, additional, Hall, H, additional, Verghese, P, additional, Mullin, A, additional, Sarpong, R, additional, Teague, J, additional, Farrelly, L, additional, Bowyer, V, additional, Gyertson, K, additional, Pervez, H, additional, Bojang, F, additional, Levermore, C, additional, Anastasiadis, T, additional, Sennett, K, additional, Navani, N, additional, Hackshaw, A, additional, and Janes, SM, additional

Published
2021
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18. P17 The SUMMIT study: results processing time

Author

Verghese, P, primary, Horst, C, additional, Dickson, J, additional, Tisi, S, additional, Hall, H, additional, Mullin, A, additional, Sarpong, R, additional, Teague, J, additional, Farrelly, L, additional, Gyertson, K, additional, Bowyer, V, additional, Levermore, C, additional, Nair, A, additional, Devaraj, A, additional, Hackshaw, A, additional, and Janes, S, additional

Published
2021
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20. SUMMIT study: protocolised management of pulmonary nodules in a lung cancer screening cohort

Author

Horst, C., primary, Dickson, J., additional, Tisi, S., additional, Hall, H., additional, Mullin, A.-M., additional, Farrelly, L., additional, Gyertson, K., additional, Levermore, C., additional, Steele, R., additional, Knights, T., additional, Clarke, C., additional, Allen, B., additional, Hamilton, S., additional, Hartmann, A.-R., additional, Nair, A., additional, Devaraj, A., additional, Hackshaw, A., additional, and Janes, S., additional

Published
2020
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21. The SUMMIT study: invitation strategy and screening uptake of the first 36,680 invited

Author

Dickson, J., primary, Quaife, S., additional, Horst, C., additional, Hall, H., additional, Tisi, S., additional, Mullin, A., additional, Farrelly, L., additional, Gyertson, K., additional, Nnorom, S., additional, Levermore, C., additional, Bojang, F., additional, Anastasiadis, T., additional, Sennett, K., additional, Clarke, C., additional, Allen, B., additional, Hamilton, S., additional, Hartmann, A., additional, Hackshaw, A., additional, and Janes, S., additional

Published
2020
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22. SUMMIT study: management of extrapulmonary incidental findings in a lung cancer screening cohort

Author

Hall, H., primary, Horst, C., additional, Dickson, J., additional, Tisi, S., additional, Mullin, A.-M., additional, Farrelly, L., additional, Gyertson, K., additional, Levermore, C., additional, Banka, R., additional, Bhowmik, A., additional, Ekeowa, U., additional, Lock, S., additional, Mangera, Z., additional, Mohammed, A., additional, Navani, N., additional, O’Shaughnessy, T., additional, Patel, A., additional, Ricketts, W., additional, Clarke, C., additional, Allen, B., additional, Hamilton, S., additional, Hartmann, A.-R., additional, Nair, A., additional, Devaraj, A., additional, Hackshaw, A., additional, and Janes, S., additional

Published
2020
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23. SUMMIT study: protocolised management of pulmonary incidental findings in a lung cancer screening cohort

Author

Tisi, S., primary, Dickson, J., additional, Horst, C., additional, Hall, H., additional, Mullin, A., additional, Farrelly, L., additional, Gyertson, K., additional, Levermore, C., additional, Clarke, C., additional, Allen, B., additional, Hamilton, S., additional, Hartmann, A., additional, Nair, A., additional, Devaraj, A., additional, Hackshaw, A., additional, and Janes, S., additional

Published
2020
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24. P78 The role of computer-assisted radiographer reporting in lung cancer screening programmes

Author

Hall, H, primary, Ruparel, M, additional, Quaife, S, additional, Dickson, JL, additional, Horst, C, additional, Tisi, S, additional, Batty, J, additional, Woznitza, N, additional, Ahmed, A, additional, Burke, S, additional, Shaw, P, additional, Soo, MJ, additional, Taylor, M, additional, Navani, N, additional, Bhowmik, A, additional, Baldwin, DR, additional, Duffy, SW, additional, Nair, A, additional, Devaraj, A, additional, and Janes, SM, additional

Published
2019
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25. Prevalence, Symptom Burden and Under-Diagnosis of COPD in a Lung Cancer Screening Cohort

Author

Ruparel, M., primary, Quaife, S.L., additional, Dickson, J.L., additional, Tisi, S., additional, Hall, H., additional, Horst, C., additional, Taylor, M., additional, Ahmed, A., additional, Shaw, P., additional, Burke, S.J., additional, Soo, M.-J., additional, Nair, A., additional, Devaraj, A., additional, Sennett, K., additional, Duffy, S.W., additional, Navani, N., additional, Bhowmik, A., additional, Baldwin, D.R., additional, and Janes, S.M., additional

Published
2019
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26. Optimising nodule management with data from the Lung Screen Uptake Trial

Author

Horst, C., primary, Ruparel, M., additional, Dickson, J., additional, Quaife, S., additional, Hall, H., additional, Tisi, S., additional, Taylor, M., additional, Ahmed, A., additional, Shaw, P., additional, Burke, S., additional, Soo, M., additional, Nair, A., additional, Devaraj, A., additional, Duffy, S., additional, Waller, J., additional, Navani, N., additional, Bhowmik, A., additional, Baldwin, D., additional, and Janes, S., additional

Published
2019
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28. The JCMT Gould Belt Survey: A First Look at the Auriga–California Molecular Cloud with SCUBA-2

Author

Broekhoven-Fiene, H., primary, Matthews, B. C., additional, Harvey, P., additional, Kirk, H., additional, Chen, M., additional, Currie, M. J., additional, Pattle, K., additional, Lane, J., additional, Buckle, J., additional, Francesco, J. Di, additional, Drabek-Maunder, E., additional, Johnstone, D., additional, Berry, D. S., additional, Fich, M., additional, Hatchell, J., additional, Jenness, T., additional, Mottram, J. C., additional, Nutter, D., additional, Pineda, J. E., additional, Quinn, C., additional, Salji, C., additional, Tisi, S., additional, Hogerheijde, M. R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C. J., additional, Duarte-Cabral, A., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Moriarty-Schieven, G., additional, Mowat, C., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Rumble, D., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wilson, C. D., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2018
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29. The JCMT Gould Belt Survey: A First Look at IC 5146

Author

Johnstone, D., primary, Ciccone, S., additional, Kirk, H., additional, Mairs, S., additional, Buckle, J., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Hatchell, J., additional, Jenness, T., additional, Mottram, J. C., additional, Pattle, K., additional, Tisi, S., additional, Francesco, J. Di, additional, Hogerheijde, M. R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coudé, S., additional, Davis, C. J., additional, Drabek-Maunder, E., additional, Duarte-Cabral, A., additional, Fich, M., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Mowat, C., additional, Nutter, D., additional, Pineda, J. E., additional, Salji, C., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Rumble, D., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2017
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30. The JCMT Gould Belt Survey: A First Look at SCUBA-2 Observations of the Lupus I Molecular Cloud

Author

Mowat, C., primary, Hatchell, J., additional, Rumble, D., additional, Kirk, H., additional, Buckle, J., additional, Berry, D.S., additional, Broekhoven-Fiene, H., additional, Currie, M.J., additional, Jenness, T., additional, Johnstone, D., additional, Mottram, J.C., additional, Pattle, K., additional, Tisi, S., additional, Francesco, J. Di, additional, Hogerheijde, M.R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coudé, S., additional, Davis, C.J., additional, Drabek-Maunder, E., additional, Duarte-Cabral, A., additional, Fich, M., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G.A., additional, Graves, S., additional, Greaves, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J.M., additional, Knee, L.B.G., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B.C., additional, Moriarty-Schieven, G., additional, Rawlings, J., additional, Retter, B., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G.J., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2017
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31. The JCMT Gould Belt Survey: first results from SCUBA-2 observations of the Cepheus Flare region

Author

Pattle, K., primary, Ward-Thompson, D., additional, Kirk, J. M., additional, Di Francesco, J., additional, Kirk, H., additional, Mottram, J. C., additional, Keown, J., additional, Buckle, J., additional, Beaulieu, S. F., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Fich, M., additional, Hatchell, J., additional, Jenness, T., additional, Johnstone, D., additional, Nutter, D., additional, Pineda, J. E., additional, Quinn, C., additional, Salji, C., additional, Tisi, S., additional, Walker-Smith, S., additional, Hogerheijde, M. R., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coudé, S., additional, Davis, C. J., additional, Drabek-Maunder, E., additional, Duarte-Cabral, A., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Mowat, C., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Rumble, D., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2016
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32. PYRROLO[3,2-H]QUINAZOLINE AS PHOTOCHEMOTHERAPEUTIC AGENTS

Author

Barraja, Paola, Caracausi, Libero, Diana, Patrizia, Carbone, Anna, Cirrincione, Girolamo, Salvador, A, Brun, P, Tisi, S, Dall'Acqua, F., BARRAJA, P, CARACAUSI, L, DIANA, P, CARBONE, A, CIRRINCIONE, G, SALVADOR, A, BRUN, P, TISI, S, and DALL'ACQUA, F

Subjects
QUINAZOLINE, ANGELICIN, PHOTOCHEMOTHERAPY, Settore CHIM/08 - Chimica Farmaceutica
Published
2010

33. PYRROLO[3,4-H]QUINAZOLINES WITH ANTITUMOR ACTIVITY

Author

Barraja, Paola, Spano', Virginia, Diana, Patrizia, Montalbano, Alessandra, Carbone, Anna, Cirrincione, Girolamo, Vedaldi, D, Tisi, S, Brun, P, Salvador, A., BARRAJA, P, SPANO', V, DIANA, P, MONTALBANO, A, CARBONE, A, CIRRINCIONE, G, VEDALDI, D, TISI, S, BRUN, P, and SALVADOR, A

Subjects
QUINAZOLINE, Settore CHIM/08 - Chimica Farmaceutica, ANTITUMOR ACTIVITY
Published
2010

34. The JCMT andHerschelGould Belt Surveys: a comparison of SCUBA-2 andHerscheldata of dense cores in the Taurus dark cloud L1495

Author

Ward-Thompson, D., primary, Pattle, K., additional, Kirk, J. M., additional, Marsh, K., additional, Buckle, J., additional, Hatchell, J., additional, Nutter, D. J., additional, Griffin, M. J., additional, Di Francesco, J., additional, André, P., additional, Beaulieu, S., additional, Berry, D., additional, Broekhoven-Fiene, H., additional, Currie, M., additional, Fich, M., additional, Jenness, T., additional, Johnstone, D., additional, Kirk, H., additional, Mottram, J., additional, Pineda, J., additional, Quinn, C., additional, Sadavoy, S., additional, Salji, C., additional, Tisi, S., additional, Walker-Smith, S., additional, White, G., additional, Hill, T., additional, Könyves, V., additional, Palmeirim, P., additional, and Pezzuto, S., additional

Published
2016
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35. THE JCMT GOULD BELT SURVEY: EVIDENCE FOR DUST GRAIN EVOLUTION IN PERSEUS STAR-FORMING CLUMPS

Author

Chen, Michael Chun-Yuan, primary, Francesco, J. Di, additional, Johnstone, D., additional, Sadavoy, S., additional, Hatchell, J., additional, Mottram, J. C., additional, Kirk, H., additional, Buckle, J., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Fich, M., additional, Jenness, T., additional, Nutter, D., additional, Pattle, K., additional, Pineda, J. E., additional, Quinn, C., additional, Salji, C., additional, Tisi, S., additional, Hogerheijde, M. R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C. J., additional, Drabek-Maunder, E., additional, Duarte-Cabral, A., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Mowat, C., additional, Pezzuto, S., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Rumble, D., additional, Schneider-Bontemps, N., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2016
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36. The JCMT Gould Belt Survey: evidence for radiative heating and contamination in the W40 complex

Author

Rumble, D., primary, Hatchell, J., additional, Pattle, K., additional, Kirk, H., additional, Wilson, T., additional, Buckle, J., additional, Berry, D.S., additional, Broekhoven-Fiene, H., additional, Currie, M.J., additional, Fich, M., additional, Jenness, T., additional, Johnstone, D., additional, Mottram, J. C., additional, Nutter, D., additional, Pineda, J.E., additional, Quinn, C., additional, Salji, C., additional, Tisi, S., additional, Walker-Smith, S., additional, Francesco, J. Di, additional, Hogerheijde, M.R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C.J., additional, Drabek-Maunder, E., additional, Duarte-Cabral, A., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G.A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Mowat, C., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2016
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37. THE JCMT GOULD BELT SURVEY: A FIRST LOOK AT DENSE CORES IN ORION B

Author

Kirk, H., primary, Francesco, J. Di, additional, Johnstone, D., additional, Duarte-Cabral, A., additional, Sadavoy, S., additional, Hatchell, J., additional, Mottram, J. C., additional, Buckle, J., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Fich, M., additional, Jenness, T., additional, Nutter, D., additional, Pattle, K., additional, Pineda, J. E., additional, Quinn, C., additional, Salji, C., additional, Tisi, S., additional, Hogerheijde, M. R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C. J., additional, Drabek-Maunder, E., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Mowat, C., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Rumble, D., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2016
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38. The JCMT Gould Belt Survey: first results from the SCUBA-2 observations of the Ophiuchus molecular cloud and a virial analysis of its prestellar core population

Author

Pattle, K., primary, Ward-Thompson, D., additional, Kirk, J. M., additional, White, G. J., additional, Drabek-Maunder, E., additional, Buckle, J., additional, Beaulieu, S. F., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Fich, M., additional, Hatchell, J., additional, Kirk, H., additional, Jenness, T., additional, Johnstone, D., additional, Mottram, J. C., additional, Nutter, D., additional, Pineda, J. E., additional, Quinn, C., additional, Salji, C., additional, Tisi, S., additional, Walker-Smith, S., additional, Francesco, J. Di, additional, Hogerheijde, M. R., additional, André, Ph., additional, Bastien, P., additional, Bresnahan, D., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C. J., additional, Duarte-Cabral, A., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Griffin, M. J., additional, Holland, W., additional, Joncas, G., additional, Knee, L. B. G., additional, Könyves, V., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Rumble, D., additional, Sadavoy, S., additional, Spinoglio, L., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2015
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39. The JCMT Gould Belt Survey: SCUBA-2 observations of circumstellar discs in L 1495

Author

Buckle, J. V., primary, Drabek-Maunder, E., additional, Greaves, J., additional, Richer, J. S., additional, Matthews, B.C., additional, Johnstone, D., additional, Kirk, H., additional, Beaulieu, S. F., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Fich, M., additional, Hatchell, J., additional, Jenness, T., additional, Mottram, J. C., additional, Nutter, D., additional, Pattle, K., additional, Pineda, J. E., additional, Salji, C., additional, Tisi, S., additional, Francesco, J. Di, additional, Hogerheijde, M. R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C. J., additional, Duarte-Cabral, A., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Moriarty-Schieven, G., additional, Rawlings, J., additional, Rosolowsky, E., additional, Rumble, D., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wilson, C. D., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2015
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40. The JCMT Gould Belt Survey: constraints on prestellar core properties in Orion A North

Author

Salji, C. J., primary, Richer, J. S., additional, Buckle, J. V., additional, Hatchell, J., additional, Kirk, H., additional, Beaulieu, S. F., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Fich, M., additional, Jenness, T., additional, Johnstone, D., additional, Mottram, J. C., additional, Nutter, D., additional, Pattle, K., additional, Pineda, J. E., additional, Quinn, C., additional, Tisi, S., additional, Walker-Smith, S., additional, Francesco, J. Di, additional, Hogerheijde, M. R., additional, Ward-Thompson, D., additional, Bastien, P., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C. J., additional, Drabek-Maunder, E., additional, Duarte-Cabral, A., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Rawlings, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Rumble, D., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wilson, C. D., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2015
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41. The JCMT Gould Belt Survey: evidence for radiative heating in Serpens MWC 297 and its influence on local star formation

Author

Rumble, D., primary, Hatchell, J., additional, Gutermuth, R. A., additional, Kirk, H., additional, Buckle, J., additional, Beaulieu, S. F., additional, Berry, D. S., additional, Broekhoven-Fiene, H., additional, Currie, M. J., additional, Fich, M., additional, Jenness, T., additional, Johnstone, D., additional, Mottram, J. C., additional, Nutter, D., additional, Pattle, K., additional, Pineda, J. E., additional, Quinn, C., additional, Salji, C., additional, Tisi, S., additional, Walker-Smith, S., additional, Francesco, J. Di, additional, Hogerheijde, M. R., additional, Ward-Thompson, D., additional, Allen, L. E., additional, Cieza, L. A., additional, Dunham, M. M., additional, Harvey, P. M., additional, Stapelfeldt, K. R., additional, Bastien, P., additional, Butner, H., additional, Chen, M., additional, Chrysostomou, A., additional, Coude, S., additional, Davis, C. J., additional, Drabek-Maunder, E., additional, Duarte-Cabral, A., additional, Fiege, J., additional, Friberg, P., additional, Friesen, R., additional, Fuller, G. A., additional, Graves, S., additional, Greaves, J., additional, Gregson, J., additional, Holland, W., additional, Joncas, G., additional, Kirk, J. M., additional, Knee, L. B. G., additional, Mairs, S., additional, Marsh, K., additional, Matthews, B. C., additional, Moriarty-Schieven, G., additional, Rawlings, J., additional, Richer, J., additional, Robertson, D., additional, Rosolowsky, E., additional, Sadavoy, S., additional, Thomas, H., additional, Tothill, N., additional, Viti, S., additional, White, G. J., additional, Wilson, C. D., additional, Wouterloot, J., additional, Yates, J., additional, and Zhu, M., additional

Published
2015
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44. The abundance of C18O and HDO in the envelope and hot core of the intermediate mass protostar NGC 7129 FIRS 2

Author

Fuente, A., primary, Caselli, P., additional, McCoey, C., additional, Cernicharo, J., additional, Johnstone, D., additional, Fich, M., additional, van Kempen, T., additional, van Dishoeck, E., additional, Yıldız, U., additional, Visser, R., additional, Kristensen, L., additional, Alonso-Albi, T., additional, Herpin, F., additional, and Tisi, S., additional

Published
2012
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46. VizieR Online Data Catalog: JCMT Gould Belt Survey: dense cores in Orion B (Kirk+, 2016)

Author

Kirk, H., Di Francesco, J., Doug Johnstone, Duarte-Cabral, A., Sadavoy, S., Hatchell, J., Mottram, J. C., Buckle, J., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Jenness, T., Nutter, D., Pattle, K., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Hogerheijde, M. R., Ward-Thompson, D., Bastien, P., Bresnahan, D., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Drabek-Maunder, E., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Matthews, B. C., Moriarty-Schieven, G., Mowat, C., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Rumble, D., Thomas, H., Tothill, N., Viti, S., White, G. J., Wouterloot, J., Yates, J., and Zhu, M.

47. VizieR Online Data Catalog: JCMT Gould Belt Survey: Serpens MWC 297 (Rumble+, 2015)

Author

Rumble, D., Hatchell, J., Gutermuth, R. A., Kirk, H., Buckle, J., Beaulieu, S. F., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Jenness, T., Johnstone, D., Mottram, J. C., Nutter, D., Pattle, K., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Walker-Smith, S., Di, Francesco J., Hogerheijde, M. R., Ward-Thompson, D., Allen, L. E., Cieza, L. A., Dunham, M. M., Harvey, P. M., Stapelfeldt, K. R., Bastien, P., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Drabek-Maunder, E., Duarte-Cabral, A., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Matthews, B. C., Moriarty-Schieven, G., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Sadavoy, S., Holly Thomas, Tothill, N., Viti, S., White, G. J., Wilson, C. D., Wouterloot, J., Yates, J., and Zhu, M.

48. VizieR Online Data Catalog: JCMT Gould Belt Survey: W40 complex (Rumble+, 2016)

Author

Rumble, D., Hatchell, J., Pattle, K., Kirk, H., Wilson, T., Buckle, J., Berry, D. S., Broekhoven-Fiene, H., Currie, M. J., Fich, M., Jenness, T., Doug Johnstone, Mottram, J. C., Nutter, D., Pineda, J. E., Quinn, C., Salji, C., Tisi, S., Walker-Smith, S., Di, Francesco J., Hogerheijde, M. R., Ward-Thompson, D., Bastien, P., Bresnahan, D., Butner, H., Chen, M., Chrysostomou, A., Coude, S., Davis, C. J., Drabek-Maunder, E., Duarte-Cabral, A., Fiege, J., Friberg, P., Friesen, R., Fuller, G. A., Graves, S., Greaves, J., Gregson, J., Holland, W., Joncas, G., Kirk, J. M., Knee, L. B. G., Mairs, S., Marsh, K., Matthews, B. C., Moriarty-Schieven, G., Mowat, C., Rawlings, J., Richer, J., Robertson, D., Rosolowsky, E., Sadavoy, S., Thomas, H., Tothill, N., Viti, S., White, G. J., Wouterloot, J., Yates, J., and Zhu, M.

49. Pyrrolo[3,2-h]quinazolines as Photochemotherapeutic Agents

Author

Anna Carbone, Patrizia Diana, Silvia Tisi, Ignazio Castagliuolo, Libero Caracausi, Girolamo Cirrincione, Alessia Salvador, Francesco Dall'Acqua, Paola Barraja, Daniela Vedaldi, Alessandra Montalbano, Paola Brun, Barraja, P, Caracausi, L, Diana, P, Montalbano, A, Carbone, A, Salvador, A, Brun, P, Castagliuolo, I, Tisi, S, Dall’Acqua, F, Vedaldi, D, and Cirrincione, G

Subjects
Pyrrolo[3, 2-h]quinazolines, Angelicin, Photochemotherapeutic Agents, Ultraviolet Rays, Apoptosis, Mitochondrion, Biochemistry, Jurkat cells, Lipid peroxidation, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Furocoumarins, Drug Discovery, Humans, Pyrrolo[3,2-h]quinazoline, Pyrroles, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, chemistry.chemical_classification, Reactive oxygen species, Photosensitizing Agents, Organic Chemistry, Settore CHIM/08 - Chimica Farmaceutica, chemistry, Cell culture, Quinolines, Molecular Medicine, Drug Screening Assays, Antitumor, Reactive Oxygen Species, Phototoxicity
Abstract

Heteroanalogues of angelicin, pyrrolo[3,2-h]quinazolines, were synthesized with the aim of obtaining new potent photochemotherapeutic agents. Many derivatives caused a significant decrease in cell proliferation in several human tumor cell lines after irradiation with UVA light (GI(50) =15.2-0.2 μM). Their phototoxicity effected apoptosis in Jurkat cells with the involvement of mitochondria (as determined by the loss of mitochondrial membrane potential and production of reactive oxygen species) and lysosomes. The phototoxicity of these compounds could be explained by lipid peroxidation.

Published
2011

50. Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity

Author

Anna Carbone, Girolamo Cirrincione, Silvia Tisi, Ignazio Castagliuolo, Olaf-Georg Issinger, Patrizia Diana, Paola Barraja, Daniela Vedaldi, Virginia Spanò, Alessandra Montalbano, Paola Brun, Irina Primac, Barbara Parrino, Alessia Salvador, Spanò, V, Montalbano, A, Carbone, A, Parrino, B, Diana, P, Cirrincione, G, Castagliuolo, I, Brun, P, Issinger, O-G, Tisi, S, Primac, I, Vedaldi, D, Salvador, A, and Barraja, P

Subjects
Programmed cell death, Mitosis, Antiproliferative activity, Cell Line, Tumor, Drug Discovery, Human Umbilical Vein Endothelial Cells, Pi, Humans, Tubulin polymerization, Pyrroles, Pyrrolo[3, Cell-mediated cytotoxicity, Pyrrolo[3,4-h]quinazolines, Antiproliferative activity, Antimitotic activity, Tubulin polymerization, Vascular disrupting activity, Vascular disrupting activity, Pharmacology, Matrigel, Cell Death, 4-h]quinazolines, Chemistry, Antimitotic activity, Organic Chemistry, General Medicine, Settore CHIM/08 - Chimica Farmaceutica, Mitochondria, Endothelial stem cell, Biochemistry, Cell culture, Apoptosis, Quinazolines, Lysosomes
Abstract

A new series of pyrrolo[3,4- h ]quinazolines was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular cytotoxicity was evaluated in vitro against 5 different human tumor cell lines with GI 50 values reaching the low micromolar level (1.3–19.8 μM). These compounds were able to induce cell death mainly by apoptosis through a mitochondrial dependent pathway. Selected compounds showed antimitotic activity and a reduction of tubulin polymerization in a concentration-dependent manner. Moreover, they showed anti-angiogenic properties since reduced in vitro endothelial cell migration and disrupted HUVEC capillary-like tube network in Matrigel.

Published
2014

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