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Your search keyword '"Tiroke, Andreas"' showing total 13 results
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13 results on '"Tiroke, Andreas"'

1. Severe aortic stenosis management in heart valve centres compared with primary/secondary care centres

Author

Rudolph, Tanja K, primary, Messika-Zeitoun, David, additional, Frey, Norbert, additional, Lutz, Matthias, additional, Krapf, Laura, additional, Passefort, Stephanie, additional, Fryearson, John, additional, Simpson, Helen, additional, Mortensen, Kai, additional, Rehse, Sebastian, additional, Tiroke, Andreas, additional, Dodos, Fotini, additional, Mies, Florian, additional, Deutsch, Cornelia, additional, Kurucova, Jana, additional, Thoenes, Martin, additional, Bramlage, Peter, additional, and Steeds, Richard Paul, additional

Published
2023
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6. Caseload management and outcome of patients with aortic stenosis in primary/secondary versus tertiary care settings—design of the IMPULSE enhanced registry

Author

Rudolph, Tanja K., primary, Messika-Zeitoun, David, additional, Frey, Norbert, additional, Lutz, Matthias, additional, Krapf, Laura, additional, Passefort, Stephanie, additional, Fryearson, John, additional, Simpson, Helen, additional, Mortensen, Kai, additional, Rehse, Sebastian, additional, Tiroke, Andreas, additional, Dodos, Fotini, additional, Mies, Florian, additional, Pohlmann, Christiane, additional, Kurucova, Jana, additional, Thoenes, Martin, additional, Bramlage, Peter, additional, and Steeds, Richard Paul, additional

Published
2019
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11. Gene expression of profibrotic mediators in bronchiolitis obliterans syndrome after lung transplantation.

Author

Bergmann, Martin, Tiroke, Andreas, Schäfer, Heiner, Barth, Jürgen, Haverich, Axel, Bergmann, M, Tiroke, A, Schäfer, H, Barth, J, and Haverich, A

Subjects
*LUNG transplantation, *COMPLICATIONS from organ transplantation, *GENE expression, *RNA analysis, *BODY fluids, *BRONCHOSCOPY, *CLINICAL trials, *COMPARATIVE studies, *CYTOMEGALOVIRUS diseases, *GENES, *GROWTH factors, *RESEARCH methodology, *MEDICAL cooperation, *PLATELET-derived growth factor, *POLYMERASE chain reaction, *PULMONARY fibrosis, *RESEARCH, *ADULT respiratory distress syndrome, *PULMONARY function tests, *RNA, *TRANSPLANTATION immunology, *BRONCHIOLE diseases, *EVALUATION research, *RANDOMIZED controlled trials, *LEUKOCYTE count
Abstract

Bronchiolitis obliterans syndrome (BOS) develops in one-third of lung transplant recipients. A fibroproliferative process involving mesenchymal cells is observed histopathologically. In order further to evaluate the pathomechanisms of BOS, the gene expression of platelet-derived growth factor (PDGF)-B and transforming growth factor (TGF)-beta 1 in bronchoalveolar lavage (BAL) cells of six lung transplant recipients and appropriate controls was studied. Equal amounts of total RNA were submitted to semiquantitative reverse transcription/polymerase chain reaction (RT-PCR), amplifying actin, PDGF-B and TGF-beta 1 using established protocols and primer sets. The signal/actin ratio was calculated based on laser densitometry measurements. TGF-beta 1 transcripts were detected in all samples, and a slight increase in BOS patients was observed. PDGF-B mRNA was increased in BAL samples from BOS patients compared to unaffected recipients and controls. Plotting the FEV1 in percent of vital capacity and the PDGF expression in BOS patients revealed an increased PDGF signal preceding lung function deterioration. The data were consistent with the hypothesis based mainly on in vitro findings that PDGF and TGF-beta contribute to the development of BOS. [ABSTRACT FROM AUTHOR]

Published
1998
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