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23. Trattamento Radiante Elettivo del Carcinoma Mammario

Author

Carlo Nervi, Creton G, Tirindelli Danesi D, and Giorgio Arcangeli

Subjects
Oncology, Cancer Research, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, General Medicine, medicine.disease, Surgery, Radiation therapy, Breast cancer, Intercurrent disease, Internal medicine, Biopsy, Medicine, Stage (cooking), Segmental resection, business, Breast carcinoma, Subclinical infection
Abstract

From March 1972 to November 1979 a total of 157 patients with stage I to III primary breast cancers have been irradiated after segmental resection (12 cases), tilectomy (89 cases) or biopsy (56 cases). Complete local control was achieved in all Stage I lesions, in 97 % Stage II lesions and in 68 % Stage III lesions. Non recurrence has been observed in patients previously operated by segmental resections, while local failures occurred in 6/89 and in 16/56 patients operated by tilectomy or biopsy, respectively. Of the 28 Stage I patients, 24 (86 %) are alive, one with distant metastases. Four patients of this group are dead, 2 of intercurrent disease and 2 of breast cancer. Of the 61 (Stage II) patients, 38 (62 %) are alive, 5 of these with distant metastases. Twenty-three patients are dead, 15 with active disease, and 8 suffered intercurrent death. Of the 68 Stage III patients, 21 (31 %) are alive, 6 of these with distant metastases. Fourty-seven patients are dead, 43 of breast cancer and 4 of intercurrent disease. The high probability of initial subclinical deposits is evidenced by the fact that 49 of the 68 patients in this group developed distant metastases. The patients with T1 lesions appear to comprise the most favourable group with a relapse free survival at five years of 76 %. The 5 years relapse free survival was 62 % for T2 lesions and 25 % for T3 and T4 lesions. N0 status does not confer the same favourable prognosis as T1 status. N+ status, however, resulted in a definitly negative prognostic factor. Cosmetic results after our treatment approach appear to be extremely good. A marked difference between the irradiated and controlateral breast occurred only in 10 of the 125 patients after a minium of 2 years observation.

Published
1982

30. A new multiparametric classification in lung cancer patients - S.M.I.G

Author

Cicconetti F, Pasquali Lasagni R, Sergio Stipa, Tirindelli Danesi D, Albertucci M, Claudio Modini, Cristiani R, and Claudio Botti

Subjects
Oncology, Cancer Research, Cell type, medicine.medical_specialty, Lung Neoplasms, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Adenocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Text mining, Internal medicine, medicine, Humans, Stage (cooking), Carcinoma, Small Cell, Lung cancer, Neoplasm Staging, Skin Tests, business.industry, General Medicine, medicine.disease, Prognosis, Bronchogenic carcinoma, Carcinoma, Squamous Cell, business
Abstract

The classification of bronchogenic carcinoma as a function of the prognosis is still an open field. The evaluation of stage, by use of the TNM system, and histologic cell type is not sufficient to guarantee a correct prognosis. The growth rate of the neoplasm is another important parameter. We propose a classification that takes into account the stage (S), histologic cell type (M), immune status (I) and the growth rate of the primary tumor (G): S.M.I.G. We studied 90 lung cancer patients according to the S.M.I.G. classification and we observed that their prognoses were directly correlated with their S.M.I.G. scores (the higher the score, the higher the 10-month mortality rate). The mortality rates within the first 10 months of follow-up were respectively 0%, 0%, 36.36%, 68%, 90.9% for the 5 groups obtained by S.M.I.G. The difference is statistically significant (P < 0.0075) and there is a linear correlation between the mortality rate and the score assigned to each group (R = 0.943; P < 0.05). The S.M.I.G. classification can predict the prognosis more efficiently than the usual classification (TNM) and histological cell type.

Published
1983

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