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16. Sur l’encadrement législatif des recherches biomédicales chez l’homme, à l’occasion de la transposition dans le droit français de la directive européenne

Author

Banzet, P., Civatte, J., Darnis, F., Dubousset, J., Küss, R., Laccourreye, H., Launois, B., Picard, J.D., Sureau, C., de Thé, G. Blaudin, Tiollais, P., Tubiana, M., Verhaeghe, M., Aurengo, Messieurs A., Bazex, J., Dubois, G., Rochefort, H., Rouëssé, J., Daurat, Madame V., Genève, MM.M., Henry-Amar, Lemaire, F., Maraninchi, Ménard, J., Michaud, J., and Rouëssé, Jacques

Published
2003
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17. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen

Author

Paterlini, P., Gerken, G., Nakajima, E., Terre, S., D'Errico, W., Grigioni, B., Nalpas, B., Franco, D., Wands, J., Kew, M., Pisi, E., Tiollais, P., and Brechot, C.

Subjects
Hepatitis B virus -- Identification and classification, Hepatitis B -- Diagnosis, Liver cancer -- Causes of, Liver cirrhosis -- Causes of, Hepatitis B -- Complications, Hepatitis associated antigen -- Measurement, Polymerase chain reaction -- Usage
Abstract

Results of epidemiologic studies strongly suggest that chronic infection with hepatitis B virus (HBV) is associated with liver cancer. HBV infection also contributes to liver cirrhosis (a chronic, degenerative disease), and cirrhosis is also correlated with liver cancer. These results are best established in patients who are HBsAg-positive (have antigens associated with hepatitis B virus on the surfaces of their cells), but the possible role of HBV in HBsAg-negative patients with liver cancer has not been as extensively explored. To better evaluate this issue, 28 HBsAg-negative patients with liver cancer were studied, using a highly sensitive assay (the polymerase chain reaction). The patients came from Italy (nine), France (10), South Africa (eight), and Japan (one). Cirrhosis was present in 22 patients. Tumor tissue was evaluated for HBV viral DNA and RNA (genetic material), and blood samples were taken to determine the presence of HBsAg and antibodies against hepatitis B proteins (anti-HBc or anti-HBs). Results showed that 10 of 23 patients had anti-HBc antibodies, anti-HBs, or both, while 13 had no markers for HBV. Eight of these 10 patients were from South Africa. HBV DNA was detected in liver tissue from 17 of the 28 patients; five from Italy, six from South Africa, five from France, and the one patient from Japan. Eight were positive for one of the anti-hepatitis B antibodies, and six had no HBV markers. Fourteen of these HBV DNA-positive tumors were from patients with cirrhosis, and three were associated with normal liver. Of the 22 patients with cirrhosis, HBV DNA was found in 14. Further investigation indicated that in some tumors the viral DNA was partially deleted. The findings suggest that in patients who are positive for anti-HBc or anti-HBs and who develop liver cancer, the viral genome may decline, resulting in HBsAg-negative test results. The persistence of HBV DNA sequences in people who have been exposed to the disease represents a risk for cancer through an unexplained mechanism. Overall, HBV DNA capable of replication was present in patients with liver cancer, even though they tested negative for HBsAg. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

27. Hepatitis B virus.

Author

Tiollais, P. and Buendia, M.

Subjects
*LIVER cancer
Abstract

Contends that new vaccines produced by genetic engineering hold the promise of eradicating liver diseases and a common form of cancer caused by the hepatitis B virus. Explanation of HBV infection; Expression of the various HBV genes; How HBV induces cancers; Molecular hybridization technique; More.

Published
1991
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