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5. FUSION RADIOLOGY FOR ENDOSCOPIC DRAINAGE OF PANCREATIC FLUID COLLECTIONS: AN INNOVATIVE SINGLE CENTER EXPERIENCE

Author

Sassatelli, R, additional, Grillo, S, additional, Cecinato, P, additional, Iori, V, additional, Besutti, G, additional, Ottone, M, additional, Rossi, PG, additional, Sereni, G, additional, Cavina, M, additional, Arona, S, additional, Bassi, F, additional, Campanale, MC, additional, Decembrino, F, additional, Lucarini, M, additional, Mirante, VG, additional, Parmeggiani, F, additional, and Tioli, C, additional

Published
2020
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6. ESD ALLOWS BETTER STRATIFICATION OF METASTATIC RISK IN NON-PEDUNCULATED PT1 COLORECTAL CANCER: A SINGLE CENTRE RETROSPECTIVE STUDY

Author

Sassatelli, R, additional, Lucarini, M, additional, Cecinato, P, additional, Iori, V, additional, Mirante, VG, additional, De Marco, L, additional, Arona, S, additional, Bassi, F, additional, Campanale, M, additional, Cavina, M, additional, Decembrino, F, additional, Grillo, S, additional, Parmeggiani, F, additional, Sereni, G, additional, Tioli, C, additional, and Zecchini, R, additional

Published
2020
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10. Prevalence of nonpolypoid colorectal neoplasia: an italian multicenter observational study

Author

Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Crotta, S, Strini, G, Orsello, M, Ballare, M, Gallo, M, Salacone, P, Asnaghi, G, Manca, A, Rizzi, R, Predebon, S, Quattrone, P, Vanni, R, Di Placido, R, Bastardini, R, Cristoni, Mv, Praiano, F, Meroni, E, Fasoli, A, Coccia, G, Allegretti, A, Manes, G, Cesari, P, Rolfi, F, Zambelli, A, Manfredi, G, Lisi, S, Cestari, R, Lancini, Gp, Crosta, C, Fiori, G, De Roberto, G, Dal Fante, M, Fazzini, L, Dinelli, M, Frego, R, Parente, F, Bargiggia, S, Paggi, S, Viale, E, Testoni, Pa, Iiritano, E, Andrian, G, Dinca, M, Germana, B, Lecis, P, Cappiello, R, Sablich, R, Tonello, C, Buri, L, Cannizzaro, R, Maiero, S, Fasoli, R, Ceroni, L, Eusebi, Lh, Iori, V, Tioli, C, Villani, V, Cortini, C, Maltoni, S, Forti, E, Solmi, L, Giovanardi, M, Calella, F, Tarantino, O, Widmayer, C, Silvestrelli, M, Bou Serhal, T, Feliciangeli, G, Tombesi, G, Anti, M, Pastorelli, A, Costamagna, G, Petruzziello, L, Cesaro, P, De Masi, E, Errico, A, Di Giulio, E, Carnuccio, A, Gabbrielli, Armando, Pandolfi, M, Lamazza, A, Femia, S, Morini, S, Lorenzetti, R, Del Vecchio Blanco, G, Grasso, E, Ferrara, M, Apuzzo, M, Iacopini, F, Milano, A, Balatsinou, C, Spadaccini, A, Silla, M, Ingrosso, M, Pirozzi, Ga, De Luca, L, De Bellis, M, Tempesta, A, De Palma GD, Siciliano, S, Di Giorgio, P, Giannattasio, F, Galloro, G, Grimaldi, E, Ciarleglio, A, Sarrantonio, G, Delle Cave, M, Lamanda, R, De Stefano, S, Labianca, O, Maisto, T, Montanaro, F, Pasquale, L, Di Girolamo, E, Piscopo, R, De Seta, M, Romano, M, Borgheresi, P, Gravina, Ag, Sarracco, P, Scaglione, G, Marmo, R, Salerno, R, Gentile, M, Annese, V, Della Valle, N, Muscatiello, N, Di Matteo, G, Giorgio, P, Fregola, G, Quatraro, F, Pisani, A, Tonti, P, Stoppino, G, Corazza, L, D'Ascoli, B, Ciuffi, M, Ignomirelli, O, Giglio, A, Rodino, S, Scanu, Am, Loriga, P, Murgia, R, Giacobbe, G, Grande, D, Montalbano, L, Linea, C., Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Testoni, PIER ALBERTO, Flat Lesions Italian, Network, DE PALMA, GIOVANNI DOMENICO, Ma, Bianco, L., Cipolletta, G., Rotondano, F., Buffoli, G., Gizzi, F., Tessari, Romano, Marco, Gravina, A. G., Maria Antonia, Bianco, Livio, Cipolletta, Gianluca, Rotondano, Federico, Buffoli, Giuseppe, Gizzi, Francesco, Tessari, and Galloro, Giuseppe

Subjects
Male, medicine.medical_specialty, Colorectal cancer, Prevalence, Colonic Polyps, Colonoscopy, Colorectal Neoplasm, colonoscopy, flat lesions, colorectal neoplasia, Gastroenterology, Internal medicine, Epidemiology, medicine, Humans, Prospective Studies, Aged, Intraepithelial neoplasia, medicine.diagnostic_test, business.industry, Cancer, Histology, Middle Aged, medicine.disease, Colonic Polyp, Prospective Studie, Italy, Observational study, Female, Colorectal Neoplasms, business, Human
Abstract

BACKGROUND AND STUDY AIM: The aim of this study was to assess the prevalence of nonpolypoid lesions (NPLs) in Italy and their risk of containing neoplasia or advanced histology. PATIENTS AND METHODS: This was a multicenter cross-sectional observational study on consecutive patients undergoing total colonoscopy over a 3-month period in 80 Italian centers. RESULTS: In all, 27,400 total colonoscopies were analyzed. Cancer was diagnosed in 801 patients (2.9 %). A total of 6553 precancerous lesions were detected in 5609 patients. Of these, 4154 patients (74.1 %) had polypoid lesions and 1455 patients (25.9 %) had NPLs. Therefore, the prevalence of NPLs was 5.3 % (95 %CI 5.0 - 5.6). NPLs larger than 10 mm were detected in 254 patients (17.5 %). NPLs were more predominant in the proximal colon (OR 2.92, 95 %CI 2.56 - 3.43; P < 0.0001 vs. polypoid lesions). Neoplastic tissue was diagnosed in 79.0 % and advanced histology (high-grade intraepithelial neoplasia or more) in 20.9 % of resected lesions. The risk of advanced histology was similar for polypoid and nonpolypoid lesions when adjusted for size. Depressed lesions had the highest risk of advanced histology (OR 10.56, 95 %CI 6.02 - 18.55; P < 0.0000 vs. flat-elevated). Age was an independent predictor of both neoplasia and advanced histology ( P = 0.0001). CONCLUSIONS: NPLs are relatively common in the Italian population, with a prevalence similar to that in other Western series. NPLs are not more aggressive than polypoid lesions, except for those with depressed morphology. Georg Thieme Verlag KG Stuttgart. New York.

Published
2010

13. P.14.2 A CAP-ASSISTED RESECTION OF INTRADUCTAL AMPULLOMA

Author

Azzolini, F., primary, Camellini, L., additional, Carella, A., additional, Cassetti, T., additional, Cavina, M., additional, Decembrino, F., additional, Iori, V., additional, Sereni, G., additional, Tioli, C., additional, and Sassatelli, R., additional

Published
2013
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16. P.1.104: A RANDOMIZED CLINICAL TRIAL COMPARING 22G AND 25G NEEDLES IN EUS-GUIDED FNA OF SOLID LESIONS

Author

Camellini, L., primary, Carlinfante, G., additional, Azzolini, F., additional, Iori, V., additional, Cavina, M., additional, Sereni, G., additional, Decembrino, F., additional, Tioli, C., additional, Gallo, C., additional, Tamagnini, I., additional, Valli, R., additional, Piana, S., additional, Campari, C., additional, Gardini, G., additional, and Sassatelli, R., additional

Published
2011
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28. Endoscopic Papillectomy for Ampullary Adenomas: Different Outcomes in Sporadic Tumors and Those Associated with Familial Adenomatous Polyposis.

Author

Cecinato P, Parmeggiani F, Braglia L, Carlinfante G, Zecchini R, Decembrino F, Iori V, Sereni G, Tioli C, Cavina M, Camellini L, Azzolini F, Ponz de Leon M, and Sassatelli R

Subjects
Humans, Neoplasm Recurrence, Local epidemiology, Retrospective Studies, Treatment Outcome, Adenomatous Polyposis Coli surgery, Ampulla of Vater surgery, Common Bile Duct Neoplasms surgery
Abstract

Background: Ampullary adenomas are rare and potentially malignant. Surgery was the standard treatment but endoscopic papillectomy (EP) is a possible alternative., Aim: We retrospectively evaluated the principal clinical outcomes of EP in all patients referred to our unit also dividing sporadic ampullary adenoma (SAA) from familial adenomatous polyposis (FAP)-associated adenomas., Methods: All consecutive patients who underwent endoscopic papillectomy because of ampullary adenoma were considered. The primary outcome was the technical success of EP. Secondary outcomes included the number of procedures, the adverse event rate, the recurrence rate, the concordance of histology pre- and post-EP, and the evaluation of factors related to technical success., Results: Between January 2001 and December 2015, sixty-two patients were included (21 FAP and 41 SAA). Technical success was achieved in 75.8% and was different in the two groups (FAP 95.2%, SAA 65.8%, p 0.025). Intraductal invasion was negatively associated with technical success (41.7% vs. 84.0%; p 0.005). The intestinal subtype was predictive of success (79.7% vs. 0%; p 0.012) as well as en bloc resection (90.3% vs. 61.3%; p 0.016). Adverse events were reported in 14 patients (22.6%)., Conclusions: EP is an effective and safe procedure and is a viable alternative to surgery., Trial Registration: ClinicalTrials.gov Identifier: NCT03494543.

Published
2021
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29. Endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction after failed ERCP in low performance status patients.

Author

Sassatelli R, Cecinato P, Lupo M, Azzolini F, Decembrino F, Iori V, Sereni G, Tioli C, Cavina M, Zecchini R, Parmeggiani F, Grillo S, and Camellini L

Subjects
Aged, Aged, 80 and over, Bile Duct Neoplasms complications, Cholangiopancreatography, Endoscopic Retrograde methods, Duodenum, Female, Humans, Jaundice, Obstructive diagnostic imaging, Male, Middle Aged, Retrospective Studies, Stents, Cholangiopancreatography, Endoscopic Retrograde adverse effects, Drainage methods, Endosonography methods, Jaundice, Obstructive surgery, Ultrasonography, Interventional
Abstract

Background: Endoscopic retrograde cholangiopancreatography (ERCP) with the placement of a biliary stent is the treatment of choice for palliation of malignant obstructive jaundice. In 5-10% of cases ERCP fails. In these cases an effective alternative is endoscopic ultrasonography-guided biliary drainage (EUS-BD)., Aim: Evaluation of the principal clinical outcomes of direct transluminal EUS-BD., Patients and Methods: This study is a retrospective analysis. All consecutive patients with malignant obstructive jaundice, in whom ERCP had failed, were enrolled. The primary outcome was the technical success of EUS-BD defined as the correct placement of the metal or plastic stent across the stomach or duodenum to the biliary tree. The most important secondary outcomes were early and late clinical success, both linked to the decrease of bilirubin haematic level., Results: Between January 2011 and November 2017 thirty-six patients were included. Technical success was obtained in 91.6%. A clinical success, early or late was obtained in 75.8%. The ECOG performance status of less than 3 was correlated with clinical success. Adverse events occurred in 30.3% of patients., Conclusions: EUS-BD is an effective and safe procedure., (Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)

Published
2020
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31. Endosonographically guided gallbladder drainage to treat neoplastic jaundice after Roux-en-Y gastric resection.

Author

Cecinato P, Cavina M, Sereni G, Decembrino F, Iori V, Tioli C, and Sassatelli R

Subjects
Adenocarcinoma secondary, Adenocarcinoma surgery, Aged, 80 and over, Anastomosis, Roux-en-Y, Endosonography, Gallbladder, Humans, Jaundice, Obstructive etiology, Male, Pancreatic Neoplasms secondary, Stomach Neoplasms surgery, Ultrasonography, Interventional methods, Adenocarcinoma complications, Drainage methods, Jaundice, Obstructive surgery, Pancreatic Neoplasms complications, Stomach Neoplasms pathology
Abstract

Competing Interests: Competing interests: None

Published
2017
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32. Endoscopic submucosal dissection of an unusual flat rectal neoplasm.

Author

Azzolini F, Cecinato P, Iori V, De Marco L, Zecchini R, Fodero C, Tioli C, and Sassatelli R

Subjects
Dissection methods, Female, Humans, Intestinal Mucosa surgery, Middle Aged, Condylomata Acuminata pathology, Condylomata Acuminata surgery, Human papillomavirus 11, Papillomavirus Infections pathology, Papillomavirus Infections surgery, Proctoscopy, Rectal Diseases pathology, Rectal Diseases surgery, Rectal Neoplasms pathology, Rectal Neoplasms surgery
Published
2015
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33. Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection.

Author

Sereni G, Azzolini F, Camellini L, Formisano D, Decembrino F, Iori V, Tioli C, Cavina M, Di Mario F, Bedogni G, and Sassatelli R

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Breath Tests, Comorbidity, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Helicobacter Infections epidemiology, Humans, Levofloxacin, Male, Middle Aged, Ofloxacin therapeutic use, Retrospective Studies, Tinidazole therapeutic use, Treatment Outcome, Ulcer drug therapy, Ulcer epidemiology, Ulcer microbiology, Young Adult, Amoxicillin therapeutic use, Clarithromycin therapeutic use, Disease Eradication methods, Helicobacter Infections drug therapy, Helicobacter Infections prevention & control, Helicobacter pylori, Proton Pump Inhibitors therapeutic use
Abstract

Aim: To determine the efficacy of our therapeutic strategy for Helicobacter pylori (H. pylori) eradication and to identify predictive factors for successful eradication., Methods: From April 2006 to June 2010, we retrospectively assessed 2428 consecutive patients (1025 men, 1403 women; mean age 55 years, age range 18-92 years) with gastric histology positive for H. pylori infection referred to our unit for 13-C urea breath test (UBT), after first-line therapy with proton pump inhibitor (PPI) b.i.d. + amoxicillin 1 g b.i.d. + clarithromycin 500 mg b.i.d. for 7 d. Patients who were still positive to UBT were recommended a second-line therapy (PPI b.i.d. + amoxicillin 1 g b.i.d. + tinidazole 500 mg b.i.d. for 14 d). Third choice treatment was empirical with PPI b.i.d. + amoxicillin 1 g b.i.d. + levofloxacin 250 mg b.i.d. for 14 d., Results: Out of 614 patients, still H. pylori-positive after first-line therapy, only 326 and 19 patients respectively rechecked their H. pylori status by UBT after the suggested second and third-line regimens. "Per protocol" eradication rates for first, second and third-line therapy were 74.7% (95% CI: 72.7%-76.4%), 85.3% (95% CI: 81.1%-89.1%) and 89.5% (95% CI: 74.9%-103%) respectively. The overall percentage of patients with H. pylori eradicated after two treatments was 97.8% (95% CI: 97.1%-98.4%), vs 99.9% (95% CI: 99.8%-100%) after three treatments. The study found that eradication therapy was most effective in patients with ulcer disease (P < 0.05, P = 0.028), especially in those with duodenal ulcer. Smoking habits did not significantly affect the eradication rate., Conclusion: First-line therapy with amoxicillin and clarithromycin produces an H. pylori eradication rate comparable or superior to other studies and second-line treatment can still be triple therapy with amoxicillin and tinidazole.

Published
2012
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