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3. Opening a new window to other worlds with spectropolarimetry

Author

Mohler, M., Bühl, J., Doherty, S., Eggl, S., Eybl, V. T., Farago, F., Jacimovic, A., Hunger, L., Lauritsen, N. L. B, Ludena, D., Meisnar, M., Reissner, A., Sarda, N., Toullec, B., and Tio, M. Vinas

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

A high level of diversity has already been observed among the planets of our own Solar System. As such, one expects extrasolar planets to present a wide range of distinctive features, therefore the characterisation of Earth- and super Earth-like planets is becoming of key importance in scientific research. The SEARCH (Spectropolarimetric Exoplanet AtmospheRe CHaracerisation) mission proposal of this paper represents one possible approach to realising these objectives. The mission goals of SEARCH include the detailed characterisation of a wide variety of exoplanets, ranging from terrestrial planets to gas giants. More specifically, SEARCH will determine atmospheric properties such as cloud coverage, surface pressure and atmospheric composition, and may also be capable of identifying basic surface features. To resolve a planet with a semi major axis of down to 1.4AU and 30pc distant SEARCH will have a mirror system consisting of two segments, with elliptical rim, cut out of a parabolic mirror. This will yield an effective diameter of 9 meters along one axis. A phase mask coronagraph along with an integral spectrograph will be used to overcome the contrast ratio of star to planet light. Such a mission would provide invaluable data on the diversity present in extrasolar planetary systems and much more could be learned from the similarities and differences compared to our own Solar System. This would allow our theories of planetary formation, atmospheric accretion and evolution to be tested, and our understanding of regions such as the outer limit of the Habitable Zone to be further improved., Comment: 23 pages, accepted for publication in Experimental Astronomy

Published
2010
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15. 21414. REGISTRO MULTICÉNTRICO BARCELONA PSP: FACTORES PRONÓSTICOS Y SUPERVIVENCIA

Author

Painous Martí, C., Cámara, A., Fernández, M., Soto, M., Muñoz, E., Martí, M., Valldeoriola, F., Pérez-Soriano, A., Garrido, A., Sánchez, A., Alba-Arbalat, S., Sánchez, V., Bargalló, N., Tió, M., Martín, N., Basora, M., Buongiorno, M., Pont-Sunyer, M., Delgado, T., Planas, A., Caballol, N., Ávila, A., Vilas, D., Jaumà, S., de Fàbregues, O., Matos, N., Mas, N., Bejr-Kasem, H., and Compta, Y.

Published
2024
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23. PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer

Author

Taylor, AM, Chan, DLH, Tio, M, Patil, SM, Traina, TA, Robson, ME, Khasraw, Mustafa, Taylor, AM, Chan, DLH, Tio, M, Patil, SM, Traina, TA, Robson, ME, and Khasraw, Mustafa

Abstract

Background: Locally advanced and metastatic breast cancer remains a challenge to treat. With emerging study results, it is important to interpret the available clinical data and apply the evidence offering the most effective treatment to the right patient. Poly(ADP Ribose) Polymerase (PARP) inhibitors are a new class of drug and their role in the treatment of locally advanced and metastatic breast cancer is being established. Objectives: To determine the efficacy, safety profile, and potential harms of Poly(ADP-Ribose) Polymerase (PARP) inhibitors in the treatment of patients with locally advanced or metastatic breast cancer. The primary outcome of interest was overall survival; secondary outcomes included progression-free survival, tumour response rate, quality of life, and adverse events. Search methods: On 8 June 2020, we searched the Cochrane Breast Cancer Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE via OvidSP, Embase via OvidSP, World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) search portal and ClinicalTrials.gov. We also searched proceedings from the major oncology conferences as well as scanned reference lists from eligible publications and contacted corresponding authors of trials for further information, where needed. Selection criteria: We included randomised controlled trials on participants with locally advanced or metastatic breast cancer comparing 1) chemotherapy in combination with PARP inhibitors, compared to the same chemotherapy without PARP inhibitors or 2) treatment with PARP inhibitors, compared to treatment with other chemotherapy. We included studies that reported on our primary outcome of overall survival and secondary outcomes including progression-free survival, tumour response rate, quality of life, and adverse events. Data collection and analysis: We used standard methodological procedures defined by Cochrane. Summary statistics for the endpoints us

Published
2021

36. Dietary oxalate intake and kidney outcomes

Author

Bargagli, M., Tio, M. C., Waikar, S. S., Ferraro, Pietro Manuel, Ferraro P. M. (ORCID:0000-0002-1379-022X), Bargagli, M., Tio, M. C., Waikar, S. S., Ferraro, Pietro Manuel, and Ferraro P. M. (ORCID:0000-0002-1379-022X)

Abstract

Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known physiological function in humans. It is predominantly eliminated by the kidneys through glomerular filtration and tubular secretion. Regardless of the cause, the increased load of dietary oxalate presented to the kidneys has been linked to different kidney-related conditions and injuries, including calcium oxalate nephrolithiasis, acute and chronic kidney disease. In this paper, we review the current literature on the association between dietary oxalate intake and kidney outcomes.

Published
2020

38. Malaysias 'nationale Kultur'

Author

Prajs-Tio, M.

Abstract

In kaum einem anderen Land ist das kulturelle und religiöse Leben von einer so großen Vielfalt geprägt wie in Malaysia. Islamische Malayen auf der malaiischen Halbinsel und die Ureinwohner Sarawaks und Sabahs erlebten während der britischen Kolonialherrschaft einen gewaltigen Zustrom von chinesischen und indischen Zuwanderern, so daß heute die 16 Millionen Bevölkerung zu 36% chinesischer und 10% indischer Abstammung sind. Die Briten hatten ihnen klare ökonomische Rollen in der Kolonialwirtschaft zugewiesen - Chinesen als Arbeiter in den Zinnminen und den Hafenstädten, Inder als Arbeiter/innen auf den großen Kautschukplantagen - um den Status der kleinbäuerlichen Malayen nicht zu verändern. (...), südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen

Published
2018
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