Search

In the quest for powerful, safe, and storable photoinduced‐electron transfer (PET) donors, the attention is turned to the α‐trihalomethylated amine moiety that is not studied in the context of PET‐reductants. The thermal and photophysical properties of α‐trifluoromethylated quinolines are thus studied and their reducing abilities evaluated as initiators of polymerization reactions. Polymers of high molecular weights are obtained through a radical polymerization process and the PET‐donor can be stored within the monomer for several months without losing its efficiency. Mechanistic investigations, combining spectroscopic analysis and theoretical calculations, confirm the mode of activation of these electron donors and the generation of radical intermediates through single electron transfer. [ABSTRACT FROM AUTHOR]

This article presents a method for synthesizing 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one, an important compound used in the production of pharmaceutical ingredients like Nirmatrelvir. The authors discuss different approaches to synthesizing this compound and propose their own efficient and scalable method involving an organocatalyzed desymmetrization step and a chemoselective reduction. They provide detailed procedures and reaction conditions for each step, along with NMR data and acknowledgments. The synthesis yields the desired compound in good yield and high purity. [Extracted from the article]