37 results on '"Ting, Yuk"'
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2. Changes in Hong Kong's Economic Structure by the New Crown Epidemic and Its Development Trend
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CHIU TING YUK
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General Medicine - Abstract
This article provides an in-depth analysis of Hong Kong's economic transformation in this COVID-19, using online research and the actual situation in Hong Kong, combined with the characteristics of Hong Kong itself. The four pillar industries of Hong Kong are financial services, tourism, trade and logistics, professional services, and other industrial support services, while in the past the major industrial sectors, except for finance, have encountered bottlenecks in the development of major industries, which have less impact on the development of Hong Kong. The inherent contradictions of our capitalism are becoming increasingly prominent, and our development approach is in urgent need of transformation and upgrading. The violent impact of infectious diseases has caused dramatic changes in the economic structure of Hong Kong. To promote the sustainable development of our economy, it is necessary to improve the rigidity of the industrial structure, reduce the gap between the rich and the poor, and develop an innovative economy.
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- 2023
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3. Energy Extraction from Low Height Sea Wave in Sarawak near Shore Region
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Heng Jong Ngu, Man Djun Lee, and Dennis Ting Yuk Shin
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Shore ,geography ,geography.geographical_feature_category ,business.industry ,Electric potential energy ,Standard deviation ,Power (physics) ,Renewable energy ,Electricity generation ,Environmental science ,Electricity ,business ,Energy (signal processing) ,Marine engineering - Abstract
Generating electricity from wave is predicted to be a new source of renewable energy conversion gaining more attention and is considered in various countries as promising renewable resource. Being surrounded by sea, Malaysia has the advantage of tapping energy from the nearest sea wave. However, Malaysia has low wave climate compared to other regions. On top of that, the technologies available for extracting this energy are still in infancy stage. This study explored the potential of generating electricity from low height wave energy. The recorded average electricity can be generated from the lab scale device which is 0.224 V, 0.175 A and 0.039 W. The data collected from Mukah Beach show that the maximum voltage recorded is 1.021 V, maximum current of 0.86 A and highest power of 0.878 W. By comparing results from both locations, the difference is almost 10-fold which validates the wave maker built in laboratory with 1:10 ratio. The standard deviation of all the outputs is small which indicates that the output generation from low height wave would be consistent. Although the output is small, it could be paired together to make a larger system to generate higher output. This study concludes that the developed lab scale model is useful for harnessing electrical energy from sea wave. The future direction of research would be to optimize the current method to maximize energy capture from sea wave. Another direction for future study is to make a system comprised of a large number of such devices to generate higher output.
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- 2019
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4. Fabrication of ultrahigh-density nanowires by electrochemical nanolithography
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Chen, Feng, Jiang, Hongquan, Kiefer, Arnold M, Clausen, Anna M, Ting, Yuk-Hong, Wendt, Amy E, Ding, Bingjun, and Lagally, Max G
- Published
- 2011
- Full Text
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5. L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression.
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Fang Du, Zhong-ming Qian, Li Zhu, Xiao Mei Wu, Wing-ho Yung, Ting-yuk Tsim, and Ya Ke
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Medicine ,Science - Abstract
BACKGROUND: The mechanisms underlying neurotoxicity caused by L-DOPA are not yet completely known. Based on recent findings, we speculated that the increased expression of divalent metal transporter 1 without iron-response element (DMT1-IRE) induced by L-DOPA might play a critical role in the development of L-DOPA neurotoxicity. To test this hypothesis, we investigated the effects of astrocyte-conditioned medium (ACM) and siRNA DMT-IRE on L-DOPA neurotoxicity in cortical neurons. METHODS AND FINDINGS: We demonstrated that neurons treated with L-DOPA have a significant dose-dependent decrease in neuronal viability (MTT Assay) and increase in iron content (using a graphite furnace atomic absorption spectrophotometer), DMT1-IRE expression (Western blot analysis) and ferrous iron (55Fe(II)) uptake. Neurons incubated in ACM with or without L-DOPA had no significant differences in their morphology, Hoechst-33342 staining or viability. Also, ACM significantly inhibited the effects of L-DOPA on neuronal iron content as well as DMT1-IRE expression. In addition, we demonstrated that infection of neurons with siRNA DMT-IRE led to a significant decrease in DMT1-IRE expression as well as L-DOPA neurotoxicity. CONCLUSION: The up-regulation of DMT1-IRE and the increase in DMT1-IRE-mediated iron influx play a key role in L-DOPA neurotoxicity in cortical neurons.
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- 2009
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6. ANALISIS PENYAJIAN SOAL LATIHAN PELAFALAN BAHASA MANDARIN DALAM BUKU ELEMENTARY COMPREHENSIVE COURSE I
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Ting, Yuk, primary
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- 2020
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7. Clostridium difficile infection outbreak in a male rehabilitation ward, Hong Kong (China), 2011
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Man-ha Wong, Shuk-kwan Chuang, Ngai-chong Tsang, Tsz-sum Lam, and Man-ting Yuk
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Clostridium difficile ,male rehabilitation ward ,Hong Kong ,Medicine ,Public aspects of medicine ,RA1-1270 - Abstract
Clostridium difficile is an anaerobic, gram-positive bacterium, capable of sporulation when environmental conditions no longer support its growth. The sporulation capacity enables the organism to persist in the environment for extended periods of time. Clostridium difficile is the main pathogen accountable for antibiotic-associated colitis and for 15% to 25% of cases of nosocomial antibiotic-associated diarrhoea. Major risk factors such as increased severity of underlying illness, increased age, prior antimicrobial use and gastric acid suppressors have been identified for Clostridium difficile.
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- 2012
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8. Management of metastatic germ cell tumors
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Hussain, Syed A, Ting, Yuk, and Cullen, Michael H
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- 2008
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9. Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial
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Jones, Robert P, Psarelli, Eftychia-Eirini, Jackson, Richard, Ghaneh, Paula, Halloran, Christopher M, Palmer, Daniel H, Campbell, Fiona, Valle, Juan W, Faluyi, Olusola, O'Reilly, Derek A, Cunningham, David, Wadsley, Jonathan, Darby, Suzanne, Meyer, Tim, Gillmore, Roopinder, Anthoney, Alan, Lind, Pehr, Glimelius, Bengt, Falk, Stephen, Izbicki, Jakob R, Middleton, Gary William, Cummins, Sebastian, Ross, Paul J, Wasan, Harpreet, McDonald, Alec, Crosby, Tom, Ting, Yuk, Patel, Kinnari, Sherriff, David, Soomal, Rubin, Borg, David, Sothi, Sharmila, Hammel, Pascal, Lerch, Markus M, Mayerle, Julia, Tjaden, Christine, Strobel, Oliver, Hackert, Thilo, Buchler, Markus W, Neoptolemos, John P, Hill, Mark, Corrie, Pippa, Hickish, Tamas, Napier, Mark, Slater, Sarah, Valle, Juan, Shablak, Alaaeldin, Cunnell, Michelle, Guimbaud, Rosine, Roques, Tom, Iveson, Tim, Jamil, Arshad, Robinson, Angus, Garcia-Alonso, Angel, Chang, David, Tsang, David, Wadd, Nick, Wall, Lucy, Nielsen, Niels Hilmer, Lerch, Markus, Mehta, Ajay, Sivaramalingam, Muthiah, Fyfe, David, Osborne, Richard, Blesing, Claire, Bulusu, Venkata Ramesh, Rathbone, Emma, Seitz, Jean-Francois, Beaumont, Erica, Dernedde, Ulrike, McAdam, Karen, Dimopoulos, Prokopios, Cominos, Mathilda, Askill, Colin, Piwowar, Andrzej, Bachet, Jean-Baptiste, Sumpter, Kate, Raouf, Sherif, Nicoll, Jonathan, Rees, Charlotte, Dhinakaran, Kathirvelu, Haux, Johan, Bengrine-Lefevre, Leila, Terrebonne, Eric, Shankland, Catherine, Palmer, Cheryl, Medley, Louise, Toy, Elizabeth, Kaur, Jasvinder, Gupta, Kamalnayan, Cheeseman, Sue, Patterson, Daniel, Candish, Charles, Thompson, Joyce, Coxon, Fareeda, Connolly, Caroline, McPhail, Neil, Williams, Rachel, Flygare, Petra, Elmlund, Mattias, Artru, Pascal, Millat, Bertrand, and Canc, European Study Grp Pancreatic
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medicine.medical_specialty ,Chemotherapy ,Randomization ,business.industry ,medicine.medical_treatment ,030230 surgery ,medicine.disease ,Gastroenterology ,Gemcitabine ,law.invention ,Capecitabine ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,030220 oncology & carcinogenesis ,Internal medicine ,Pancreatic cancer ,medicine ,Carcinoma ,Surgery ,Prospective cohort study ,business ,medicine.drug - Abstract
Importance The patterns of disease recurrence after resection of pancreatic ductal adenocarcinoma with adjuvant chemotherapy remain unclear. Objective To define patterns of recurrence after adjuvant chemotherapy and the association with survival. Design, Setting, and Participants Prospectively collected data from the phase 3 European Study Group for Pancreatic Cancer 4 adjuvant clinical trial, an international multicenter study. The study included 730 patients who had resection and adjuvant chemotherapy for pancreatic cancer. Data were analyzed between July 2017 and May 2019. Interventions Randomization to adjuvant gemcitabine or gemcitabine plus capecitabine. Main Outcomes and Measures Overall survival, recurrence, and sites of recurrence. Results Of the 730 patients, median age was 65 years (range 37-81 years), 414 were men (57%), and 316 were women (43%). The median follow-up time from randomization was 43.2 months (95% CI, 39.7-45.5 months), with overall survival from time of surgery of 27.9 months (95% CI, 24.8-29.9 months) with gemcitabine and 30.2 months (95% CI, 25.8-33.5 months) with the combination (HR, 0.81; 95% CI, 0.68-0.98;P = .03). The 5-year survival estimates were 17.1% (95% CI, 11.6%-23.5%) and 28.0% (22.0%-34.3%), respectively. Recurrence occurred in 479 patients (65.6%); another 78 patients (10.7%) died without recurrence. Local recurrence occurred at a median of 11.63 months (95% CI, 10.05-12.19 months), significantly different from those with distant recurrence with a median of 9.49 months (95% CI, 8.44-10.71 months) (HR, 1.21; 95% CI, 1.01-1.45;P = .04). Following recurrence, the median survival was 9.36 months (95% CI, 8.08-10.48 months) for local recurrence and 8.94 months (95% CI, 7.82-11.17 months) with distant recurrence (HR, 0.89; 95% CI, 0.73-1.09;P = .27). The median overall survival of patients with distant-only recurrence (23.03 months; 95% CI, 19.55-25.85 months) or local with distant recurrence (23.82 months; 95% CI, 17.48-28.32 months) was not significantly different from those with only local recurrence (24.83 months; 95% CI, 22.96-27.63 months) (P = .85 andP = .35, respectively). Gemcitabine plus capecitabine had a 21% reduction of death following recurrence compared with monotherapy (HR, 0.79; 95% CI, 0.64-0.98;P = .03). Conclusions and Relevance There were no significant differences between the time to recurrence and subsequent and overall survival between local and distant recurrence. Pancreatic cancer behaves as a systemic disease requiring effective systemic therapy after resection. Trial Registration ClinicalTrials.gov identifier:NCT00058201, EudraCT 2007-004299-38, and ISRCTN 96397434.
- Published
- 2019
10. Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma : A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial
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Jones, Robert P., Psarelli, Eftychia-Eirini, Jackson, Richard, Ghaneh, Paula, Halloran, Christopher M., Palmer, Daniel H., Campbell, Fiona, Valle, Juan W., Faluyi, Olusola, O'Reilly, Derek A., Cunningham, David, Wadsley, Jonathan, Darby, Suzanne, Meyer, Tim, Gillmore, Roopinder, Anthoney, Alan, Lind, Pehr, Glimelius, Bengt, Falk, Stephen, Izbicki, Jakob R., Middleton, Gary William, Cummins, Sebastian, Ross, Paul J., Wasan, Harpreet, McDonald, Alec, Crosby, Tom, Ting, Yuk, Patel, Kinnari, Sherriff, David, Soomal, Rubin, Borg, David, Sothi, Sharmila, Hammel, Pascal, Lerch, Markus M., Mayerle, Julia, Tjaden, Christine, Strobel, Oliver, Hackert, Thilo, Buchler, Markus W., Neoptolemos, John P., Hill, Mark, Corrie, Pippa, Hickish, Tamas, Napier, Mark, Slater, Sarah, Valle, Juan, Shablak, Alaaeldin, Cunnell, Michelle, Guimbaud, Rosine, Roques, Tom, Iveson, Tim, Jamil, Arshad, Robinson, Angus, Garcia-Alonso, Angel, Chang, David, Tsang, David, Wadd, Nick, Wall, Lucy, Nielsen, Niels Hilmer, Lerch, Markus, Mehta, Ajay, Sivaramalingam, Muthiah, Fyfe, David, Osborne, Richard, Blesing, Claire, Bulusu, Venkata Ramesh, Rathbone, Emma, Seitz, Jean-Francois, Beaumont, Erica, Dernedde, Ulrike, McAdam, Karen, Dimopoulos, Prokopios, Cominos, Mathilda, Askill, Colin, Piwowar, Andrzej, Bachet, Jean-Baptiste, Sumpter, Kate, Raouf, Sherif, Nicoll, Jonathan, Rees, Charlotte, Dhinakaran, Kathirvelu, Haux, Johan, Bengrine-Lefevre, Leila, Terrebonne, Eric, Shankland, Catherine, Palmer, Cheryl, Medley, Louise, Toy, Elizabeth, Kaur, Jasvinder, Gupta, Kamalnayan, Cheeseman, Sue, Patterson, Daniel, Candish, Charles, Thompson, Joyce, Coxon, Fareeda, Connolly, Caroline, McPhail, Neil, Williams, Rachel, Flygare, Petra, Elmlund, Mattias, Artru, Pascal, Millat, Bertrand, Jones, Robert P., Psarelli, Eftychia-Eirini, Jackson, Richard, Ghaneh, Paula, Halloran, Christopher M., Palmer, Daniel H., Campbell, Fiona, Valle, Juan W., Faluyi, Olusola, O'Reilly, Derek A., Cunningham, David, Wadsley, Jonathan, Darby, Suzanne, Meyer, Tim, Gillmore, Roopinder, Anthoney, Alan, Lind, Pehr, Glimelius, Bengt, Falk, Stephen, Izbicki, Jakob R., Middleton, Gary William, Cummins, Sebastian, Ross, Paul J., Wasan, Harpreet, McDonald, Alec, Crosby, Tom, Ting, Yuk, Patel, Kinnari, Sherriff, David, Soomal, Rubin, Borg, David, Sothi, Sharmila, Hammel, Pascal, Lerch, Markus M., Mayerle, Julia, Tjaden, Christine, Strobel, Oliver, Hackert, Thilo, Buchler, Markus W., Neoptolemos, John P., Hill, Mark, Corrie, Pippa, Hickish, Tamas, Napier, Mark, Slater, Sarah, Valle, Juan, Shablak, Alaaeldin, Cunnell, Michelle, Guimbaud, Rosine, Roques, Tom, Iveson, Tim, Jamil, Arshad, Robinson, Angus, Garcia-Alonso, Angel, Chang, David, Tsang, David, Wadd, Nick, Wall, Lucy, Nielsen, Niels Hilmer, Lerch, Markus, Mehta, Ajay, Sivaramalingam, Muthiah, Fyfe, David, Osborne, Richard, Blesing, Claire, Bulusu, Venkata Ramesh, Rathbone, Emma, Seitz, Jean-Francois, Beaumont, Erica, Dernedde, Ulrike, McAdam, Karen, Dimopoulos, Prokopios, Cominos, Mathilda, Askill, Colin, Piwowar, Andrzej, Bachet, Jean-Baptiste, Sumpter, Kate, Raouf, Sherif, Nicoll, Jonathan, Rees, Charlotte, Dhinakaran, Kathirvelu, Haux, Johan, Bengrine-Lefevre, Leila, Terrebonne, Eric, Shankland, Catherine, Palmer, Cheryl, Medley, Louise, Toy, Elizabeth, Kaur, Jasvinder, Gupta, Kamalnayan, Cheeseman, Sue, Patterson, Daniel, Candish, Charles, Thompson, Joyce, Coxon, Fareeda, Connolly, Caroline, McPhail, Neil, Williams, Rachel, Flygare, Petra, Elmlund, Mattias, Artru, Pascal, and Millat, Bertrand
- Abstract
Importance: The patterns of disease recurrence after resection of pancreatic ductal adenocarcinoma with adjuvant chemotherapy remain unclear. Objective: To define patterns of recurrence after adjuvant chemotherapy and the association with survival. Design, Setting, and Participants: Prospectively collected data from the phase 3 European Study Group for Pancreatic Cancer 4 adjuvant clinical trial, an international multicenter study. The study included 730 patients who had resection and adjuvant chemotherapy for pancreatic cancer. Data were analyzed between July 2017 and May 2019. Interventions: Randomization to adjuvant gemcitabine or gemcitabine plus capecitabine. Main Outcomes and Measures: Overall survival, recurrence, and sites of recurrence. Results: Of the 730 patients, median age was 65 years (range 37-81 years), 414 were men (57%), and 316 were women (43%). The median follow-up time from randomization was 43.2 months (95% CI, 39.7-45.5 months), with overall survival from time of surgery of 27.9 months (95% CI, 24.8-29.9 months) with gemcitabine and 30.2 months (95% CI, 25.8-33.5 months) with the combination (HR, 0.81; 95% CI, 0.68-0.98; P=.03). The 5-year survival estimates were 17.1% (95% CI, 11.6%-23.5%) and 28.0% (22.0%-34.3%), respectively. Recurrence occurred in 479 patients (65.6%); another 78 patients (10.7%) died without recurrence. Local recurrence occurred at a median of 11.63 months (95% CI, 10.05-12.19 months), significantly different from those with distant recurrence with a median of 9.49 months (95% CI, 8.44-10.71 months) (HR, 1.21; 95% CI, 1.01-1.45; P=.04). Following recurrence, the median survival was 9.36 months (95% CI, 8.08-10.48 months) for local recurrence and 8.94 months (95% CI, 7.82-11.17 months) with distant recurrence (HR, 0.89; 95% CI, 0.73-1.09; P=.27). The median overall survival of patients with distant-only recurrence (23.03 months; 95% CI, 19.55-25.85 months) or local with distant recurrence (23.82 months; 95% CI, 17.48-28.32
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- 2019
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11. Energy Extraction from Low Height Sea Wave in Sarawak near Shore Region
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Lee, Man Djun, primary, Ngu, Heng Jong, additional, and Shin, Dennis Ting Yuk, additional
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- 2019
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12. Fabrication of ultrahigh-density nanowires by electrochemical nanolithography
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Jiang Hongquan, Kiefer Arnold, Clausen Anna, Ting Yuk-Hong, Wendt Amy, Lagally Max, Chen Feng, and Ding Bingjun
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract An approach has been developed to produce silver nanoparticles (AgNPs) rapidly on semiconductor wafers using electrochemical deposition. The closely packed AgNPs have a density of up to 1.4 × 1011 cm-2 with good size uniformity. AgNPs retain their shape and position on the substrate when used as nanomasks for producing ultrahigh-density vertical nanowire arrays with controllable size, making it a one-step nanolithography technique. We demonstrate this method on Si/SiGe multilayer superlattices using electrochemical nanopatterning and plasma etching to obtain high-density Si/SiGe multilayer superlattice nanowires.
- Published
- 2011
13. An Analytical and Experimental Investigation of Polycal Wire Rope Vibration Isolators for Industrial Equipment
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Ting, Yuk Shyk and Ting, Yuk Shyk
- Abstract
The Polycal Wire Rope Isolator (PWRI) is effective in isolating vibrations for equipment. The proposed work is to perform an analytical and experimental investigation on the PWRI in both vertical and lateral directions. The analytical model of static elastic stiffnesses of polycal WRI were developed using Castigliano’s second theorem and were validated using monotonic loading tests. Meanwhile, the damping characteristics of WRI were studied using the cyclic loading tests.
- Published
- 2018
14. Corynebacterium kroppenstedtii Is an Emerging Cause of Mastitis Especially in Patients With Psychiatric Illness on Antipsychotic Medication
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Ingrid Y.Y. Cheung, Man-Ting Yuk, Sally C. Y. Wong, Janice Y.C. Lo, Herman Tse, Kwok-Yung Yuen, Rosana W.S. Poon, Jonathan H. K. Chen, Wei-Kwang Luk, Tak-Keung Ng, Cindy W. S. Tse, and Jonathan C K Au
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0301 basic medicine ,medicine.medical_specialty ,Corynebacterium kroppenstedtii ,antipsychotics agents ,medicine.medical_treatment ,Granulomatous mastitis ,03 medical and health sciences ,0302 clinical medicine ,medicine ,hyperprolactinaemia ,In patient ,Risk factor ,Psychiatry ,Antipsychotic ,business.industry ,Brief Report ,Hyperprolactinaemia ,Retrospective cohort study ,medicine.disease ,infection ,Mastitis ,030104 developmental biology ,Infectious Diseases ,Oncology ,030220 oncology & carcinogenesis ,business ,granulomatous mastitis - Abstract
This retrospective study of patients with Corynebacterium kroppenstedtii infections revealed a predominance of mastitis and a potential association with psychiatric illnesses. At least one third of our patients with C kroppenstedtii mastitis had psychiatric illness, and >92% received antipsychotic medications. Drug-induced hyperprolactinemia may be an important modifiable risk factor in these patients.
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- 2017
15. Experimental study on vertical static stiffnesses of polycal wire rope isolators
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Balaji, P.S., primary, Moussa, Leblouba, additional, Khandoker, Noman, additional, Shyh, Ting Yuk, additional, Rahman, M.E., additional, and Ho, Lau Hieng, additional
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- 2017
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16. Experimental study on vertical static stiffnesses of polycal wire rope isolators
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Lau Hieng Ho, Leblouba Moussa, Ting Yuk Shyh, Muhammad Ekhlasur Rahman, Noman Khandoker, and P. S. Balaji
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Tension (physics) ,business.industry ,Isolator ,H300 ,Stiffness ,H900 ,Wire rope ,Structural engineering ,H700 ,engineering.material ,Width ratio ,Compression (physics) ,Vibration ,engineering ,medicine ,medicine.symptom ,Compressive stiffness ,business - Abstract
Wire rope isolator is one of the most effective isolation system that can be used to attenuate the vibration disturbances and shocks during the operation of machineries. This paper presents the results of investigation on static elastic stiffnesses (both in tension and in compression) of Polycal Wire Rope Isolator (PWRI) under quasi-static monotonic loading conditions. It also studied effect of variations in height and width of PWRI on its static stiffnesses. Suitable experimental setup was designed and manufactured to meet the test conditions. The results show that their elastic stiffnesses for both tension and compression loading conditions are highly influenced by their geometric dimensions. It is found that their compressive stiffness reduced by 55% for an increment of 20% in their height to width ratio. Therefore, the stiffness of PWRI can be fine-tuned by controlling their dimensions according to the requirements of the application.
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- 2017
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17. Clostridium difficile infection outbreak in a male rehabilitation ward, Hong Kong Special Administrative Region (China), 2011
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Tsz-Sum, Lam, Man-Ting, Yuk, Ngai-Chong, Tsang, Man-Ha, Wong, and Shuk-Kwan, Chuang
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Outbreak Investigations in the Western Pacific - Published
- 2013
18. Trends in mortality, morbidity and early neurodevelopment outcomes among infants with extremely low birth weight
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Ting, Yuk, Joseph
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Low birth weight ,Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,medicine.symptom ,business - Published
- 2012
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19. Corynebacterium kroppenstedtii Is an Emerging Cause of Mastitis Especially in Patients With Psychiatric Illness on Antipsychotic Medication.
- Author
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Wong, Sally C. Y., Poon, Rosana W. S., Chen, Jonathan H. K., Tse, Herman, Lo, Janice Y. C., Ng, Tak-Keung, Au, Jonathan C. K., Tse, Cindy W. S., Cheung, Ingrid Y. Y., Man-Ting Yuk, Wei-Kwang Luk, and Kwok-Yung Yuen
- Subjects
CORYNEBACTERIUM diseases ,MASTITIS ,ANTIPSYCHOTIC agents - Abstract
This retrospective study of patients with Corynebacterium kroppenstedtii infections revealed a predominance of mastitis and a potential association with psychiatric illnesses. At least one third of our patients with C kroppenstedtii mastitis had psychiatric illness, and >92% received antipsychotic medications. Drug-induced hyperprolactinemia may be an important modifiable risk factor in these patients. [ABSTRACT FROM AUTHOR]
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- 2017
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20. Bordetella bronchisepticaPneumonia in an Extremely-Low-Birth-Weight Neonate
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Ting, Yuk, primary, Ho, Pak-leung, additional, and Wong, Kar-yin, additional
- Published
- 2011
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21. Gastric Pneumatosis in a Premature Neonate
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Ting, Yuk, primary, Chan, Kwong-leung, additional, Wong, Siu-chun Mabel, additional, Chim, Stella, additional, and Wong, Kar-yin, additional
- Published
- 2011
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22. Surface Roughening of Polystyrene and Poly(methyl methacrylate) in Ar/O2 Plasma Etching
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Ting, Yuk-Hong, primary, Liu, Chi-Chun, additional, Park, Sang-Min, additional, Jiang, Hongquan, additional, Nealey, Paul F., additional, and Wendt, Amy E., additional
- Published
- 2010
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23. Trends in mortality, morbidity and early neurodevelopment outcomes among infants with extremely low birth weight
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Ting, Yuk, Joseph, primary
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24. L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression
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Du, Fang, primary, Qian, Zhong-ming, additional, Zhu, Li, additional, Wu, Xiao Mei, additional, Yung, Wing-ho, additional, Tsim, Ting-yuk, additional, and Ke, Ya, additional
- Published
- 2009
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25. Sub‐micron and nanoscale feature depth modulates alignment of stromal fibroblasts and corneal epithelial cells in serum‐rich and serum‐free media
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Fraser, Sarah A., primary, Ting, Yuk‐Hong, additional, Mallon, Kelly S., additional, Wendt, Amy E., additional, Murphy, Christopher J., additional, and Nealey, Paul F., additional
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- 2008
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26. Plasma etch removal of poly(methyl methacrylate) in block copolymer lithography
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Ting, Yuk-Hong, primary, Park, Sang-Min, additional, Liu, Chi-Chun, additional, Liu, Xiaosong, additional, Himpsel, F. J., additional, Nealey, Paul F., additional, and Wendt, Amy E., additional
- Published
- 2008
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27. Gene expressions during the development of olfactory bulb in rats.
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Tsim, Ting Yuk., Chinese University of Hong Kong Graduate School. Division of Physiology., Tsim, Ting Yuk., and Chinese University of Hong Kong Graduate School. Division of Physiology.
- Abstract
Tsim Ting Yuk., Thesis (M.Phil.)--Chinese University of Hong Kong, 2000., Includes bibliographical references (leaves 119-135)., s in English and Chinese., p.i, 摘要 --- p.iii, 英漢譯名對照 --- p.v, ABBREVIATIONS --- p.vi, ACKNOWLEDGMENTS --- p.viii, Chapter 1. --- Introduction, Chapter 1.1. --- Olfactory system --- p.1, Chapter 1.1.1. --- Olfactory bulb (OB) --- p.1, Chapter 1.1.2. --- Accessory olfactory bulb (AOB) --- p.3, Chapter 1.2. --- Stem cells --- p.5, Chapter 1.3. --- Sexual differentiation --- p.8, Chapter 1.3.1. --- Sexual dimorphic olfactory system --- p.8, Chapter 1.3.2. --- Androgen receptor (AR) & estrogen receptor beta (ERβ) --- p.13, Chapter 1.3.3. --- Aromatase --- p.15, Chapter 1.3.4. --- Oligomycin sensitivity-conferringrotein (OSCP) --- p.18, Chapter 1.4. --- rogrammed cell death (PCD) --- p.18, Chapter 1.4.1. --- CD in the olfactory development --- p.18, Chapter 1.4.2. --- Caspase 3 --- p.22, Chapter 1.4.3. --- B cell leukemia/ Lymphoma 2 (Bcl-2) --- p.23, Chapter 1.5. --- Axon guidance molecules --- p.25, Chapter 1.5.1. --- Growth cone --- p.25, Chapter 1.5.2. --- Mechanisms of growth cone advance --- p.26, Chapter 1.5.3. --- Semaphorins --- p.28, Chapter 1.5.4. --- Neuropilin --- p.31, Chapter 1.5.5. --- lexin --- p.32, Chapter 1.5.6. --- Collapsin response mediatorroteins (CRMPs) --- p.32, Chapter 1.6. --- Olfactory markerroteins --- p.33, Chapter 1.6.1. --- Markerroteins in ORNs --- p.33, Chapter 1.6.2. --- Growth associatedrotein (GAP-43) --- p.34, Chapter 1.6.3. --- Is the expression of GAP-43 in rat OB sexually dimorphic? --- p.36, Chapter 1.6.4. --- Olfactory markerrotein (OMP) --- p.38, Chapter 1.6.5. --- Golf --- p.39, Chapter 1.7. --- Miscellaneous genes --- p.40, Chapter 1.7.1. --- Substance (SP) --- p.40, Chapter 1.7.2. --- Gonadotropin releasing hormone (GnRH) --- p.41, Chapter 1.7.3. --- Metabotropic glutamate receptor 2 (mGluR2) --- p.42, Chapter 1.7.4. --- Insulin-like growth factor binding protein-2 (IGFBP2) --- p.43, Chapter 2. --- Materials and methods, Chapter 2.1. --- Animal study --- p.46, Chapter 2.2. --- RNA extraction --- p.46, Chapter 2.3. --- Quantitation of total RNA --- p.49, Chapter 2.4. --- Reverse Transcription (RT) --- p.50, Chapter 2.5. --- olymerase Chain Reaction (PCR) --- p.51, Chapter 2.6. --- urification ofCRroducts --- p.55, Chapter 2.7. --- Confirmation ofCRroducts --- p.56, Chapter 2.8. --- Quantitation of cDNA --- p.57, Chapter 2.9. --- Radioactive labeledCR --- p.58, Chapter 2.10. --- Electrophoresis ofCRroducts --- p.59, Chapter 2.11. --- Statistical analysis --- p.60, Chapter 3. --- Results, Chapter 3.1. --- Standard curve construction --- p.61, Chapter 3.2. --- β-actin --- p.62, Chapter 3.3. --- Sexual differentiation related genes --- p.64, Chapter 3.3.1. --- AR --- p.64, Chapter 3.3.2. --- ERβ --- p.65, Chapter 3.3.3. --- Aromatase --- p.65, Chapter 3.3.4. --- OSCP --- p.66, Chapter 3.4. --- CD related genes --- p.66, Chapter 3.4.1. --- Bcl-2α --- p.66, Chapter 3.4.2. --- Caspase 3 --- p.67, Chapter 3.5. --- Axon guidance molecules and related genes --- p.67, Chapter 3.5.1. --- SemaIII --- p.67, Chapter 3.5.2. --- Neuropilin-1 --- p.68, Chapter 3.5.3. --- lexin-1 --- p.68, Chapter 3.5.4. --- CRMP-1 --- p.69, Chapter 3.5.5. --- CRMP-2 --- p.70, Chapter 3.5.6. --- CRMP-3 --- p.70, Chapter 3.5.7. --- CRMP-4 --- p.71, Chapter 3.6. --- Olfactory markerrotein genes --- p.71, Chapter 3.6.1. --- GAP-43 --- p.71, Chapter 3.6.2. --- OMP --- p.72, Chapter 3.6.3. --- Golf --- p.72, Chapter 3.7. --- Miscellaneous genes --- p.73, Chapter 3.7.1. --- SubstanceP --- p.73, Chapter 3.7.2. --- GnRH --- p.73, Chapter 3.7.3. --- mGluR2 --- p.74, Chapter 3.7.4. --- IGFBP-2 --- p.74, Chapter 3.8. --- Graphs and tables --- p.75, Chapter 4. --- Discussion, Chapter 4.1. --- Quantitation of cDNA and normalization of CR results --- p.97, Chapter 4.2. --- Sexual differentiation related genes --- p.98, Chapter 4.3. --- CD related genes --- p.100, Chapter 4.4. --- Axon guidance molecule and related genes --- p.103, Chapter 4.5. --- Olfactory markerrotein genes --- p.109, Chapter 4.6. --- Miscellaneous genes --- p.112, Chapter 5. --- References --- p.119, http://library.cuhk.edu.hk/record=b5890486, Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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- 2000
28. L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression
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Xiao Mei Wu, Ya Ke, Ting-yuk Tsim, Fang Du, Zhong-Ming Qian, Li Zhu, and Wing-Ho Yung
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Neurotoxicity Syndrome ,Iron ,lcsh:Medicine ,Response Elements ,Levodopa ,Downregulation and upregulation ,Western blot ,medicine ,Animals ,MTT assay ,Rats, Wistar ,lcsh:Science ,Cation Transport Proteins ,Cells, Cultured ,Cerebral Cortex ,Neurons ,Multidisciplinary ,Physiology/Neuronal Signaling Mechanisms ,Dose-Response Relationship, Drug ,medicine.diagnostic_test ,biology ,Chemistry ,lcsh:R ,digestive, oral, and skin physiology ,fungi ,Neurotoxicity ,Transporter ,DMT1 ,medicine.disease ,Molecular biology ,Rats ,Neurological Disorders/Neuropharmacology ,medicine.anatomical_structure ,Pharmacology/Adverse Reactions ,Cerebral cortex ,Astrocytes ,Culture Media, Conditioned ,biology.protein ,Neurotoxicity Syndromes ,lcsh:Q ,Research Article - Abstract
Background The mechanisms underlying neurotoxicity caused by L-DOPA are not yet completely known. Based on recent findings, we speculated that the increased expression of divalent metal transporter 1 without iron-response element (DMT1−IRE) induced by L-DOPA might play a critical role in the development of L-DOPA neurotoxicity. To test this hypothesis, we investigated the effects of astrocyte-conditioned medium (ACM) and siRNA DMT-IRE on L-DOPA neurotoxicity in cortical neurons. Methods and Findings We demonstrated that neurons treated with L-DOPA have a significant dose-dependent decrease in neuronal viability (MTT Assay) and increase in iron content (using a graphite furnace atomic absorption spectrophotometer), DMT1−IRE expression (Western blot analysis) and ferrous iron (55Fe(II)) uptake. Neurons incubated in ACM with or without L-DOPA had no significant differences in their morphology, Hoechst-33342 staining or viability. Also, ACM significantly inhibited the effects of L-DOPA on neuronal iron content as well as DMT1−IRE expression. In addition, we demonstrated that infection of neurons with siRNA DMT-IRE led to a significant decrease in DMT1−IRE expression as well as L-DOPA neurotoxicity. Conclusion The up-regulation of DMT1−IRE and the increase in DMT1−IRE-mediated iron influx play a key role in L-DOPA neurotoxicity in cortical neurons.
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- 2009
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29. Pattern transfer using poly(styrene-block-methyl methacrylate) copolymer films and reactive ion etching
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Liu, Chi-Chun, primary, Nealey, Paul F., additional, Ting, Yuk-Hong, additional, and Wendt, Amy E., additional
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- 2007
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30. Measurement of plasma potential fluctuations by emissive probes in CF4radio-frequency plasma
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Lee, Dongsoo, primary, Ting, Yuk-Hong, additional, Oksuz, Lutfi, additional, and Hershkowitz, Noah, additional
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- 2006
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31. Bordetella bronchiseptica Pneumonia in an Extremely-Low-Birth-Weight Neonate
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Ting, Yuk Joseph, Ho, Pak-leung, and Wong, Kar-yin
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- 2011
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32. Experimental study on vertical static stiffnesses of polycal wire rope isolators.
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P.S. Balaji, Leblouba Moussa, Noman Khandoker, Ting Yuk Shyh, M.E. Rahman, and Lau Hieng Ho
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- 2017
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33. Clostridium diffi cile infection outbreak in a male rehabilitation ward, Hong Kong (China), 2011.
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Tsz-sum Lam, Man-ting Yuk, Ngai-chong Tsang, Man-ha Wong, and Shuk-kwan Chuang
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- 2012
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34. Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial.
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Jones RP, Psarelli EE, Jackson R, Ghaneh P, Halloran CM, Palmer DH, Campbell F, Valle JW, Faluyi O, O'Reilly DA, Cunningham D, Wadsley J, Darby S, Meyer T, Gillmore R, Anthoney A, Lind P, Glimelius B, Falk S, Izbicki JR, Middleton GW, Cummins S, Ross PJ, Wasan H, McDonald A, Crosby T, Ting Y, Patel K, Sherriff D, Soomal R, Borg D, Sothi S, Hammel P, Lerch MM, Mayerle J, Tjaden C, Strobel O, Hackert T, Büchler MW, and Neoptolemos JP
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- Adult, Aged, Aged, 80 and over, Capecitabine administration & dosage, Carcinoma, Pancreatic Ductal drug therapy, Carcinoma, Pancreatic Ductal mortality, Chemotherapy, Adjuvant, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Disease-Free Survival, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local mortality, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms mortality, Prospective Studies, Treatment Outcome, Gemcitabine, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Pancreatic Ductal surgery, Neoplasm Recurrence, Local etiology, Pancreatic Neoplasms surgery
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Importance: The patterns of disease recurrence after resection of pancreatic ductal adenocarcinoma with adjuvant chemotherapy remain unclear., Objective: To define patterns of recurrence after adjuvant chemotherapy and the association with survival., Design, Setting, and Participants: Prospectively collected data from the phase 3 European Study Group for Pancreatic Cancer 4 adjuvant clinical trial, an international multicenter study. The study included 730 patients who had resection and adjuvant chemotherapy for pancreatic cancer. Data were analyzed between July 2017 and May 2019., Interventions: Randomization to adjuvant gemcitabine or gemcitabine plus capecitabine., Main Outcomes and Measures: Overall survival, recurrence, and sites of recurrence., Results: Of the 730 patients, median age was 65 years (range 37-81 years), 414 were men (57%), and 316 were women (43%). The median follow-up time from randomization was 43.2 months (95% CI, 39.7-45.5 months), with overall survival from time of surgery of 27.9 months (95% CI, 24.8-29.9 months) with gemcitabine and 30.2 months (95% CI, 25.8-33.5 months) with the combination (HR, 0.81; 95% CI, 0.68-0.98; P = .03). The 5-year survival estimates were 17.1% (95% CI, 11.6%-23.5%) and 28.0% (22.0%-34.3%), respectively. Recurrence occurred in 479 patients (65.6%); another 78 patients (10.7%) died without recurrence. Local recurrence occurred at a median of 11.63 months (95% CI, 10.05-12.19 months), significantly different from those with distant recurrence with a median of 9.49 months (95% CI, 8.44-10.71 months) (HR, 1.21; 95% CI, 1.01-1.45; P = .04). Following recurrence, the median survival was 9.36 months (95% CI, 8.08-10.48 months) for local recurrence and 8.94 months (95% CI, 7.82-11.17 months) with distant recurrence (HR, 0.89; 95% CI, 0.73-1.09; P = .27). The median overall survival of patients with distant-only recurrence (23.03 months; 95% CI, 19.55-25.85 months) or local with distant recurrence (23.82 months; 95% CI, 17.48-28.32 months) was not significantly different from those with only local recurrence (24.83 months; 95% CI, 22.96-27.63 months) (P = .85 and P = .35, respectively). Gemcitabine plus capecitabine had a 21% reduction of death following recurrence compared with monotherapy (HR, 0.79; 95% CI, 0.64-0.98; P = .03)., Conclusions and Relevance: There were no significant differences between the time to recurrence and subsequent and overall survival between local and distant recurrence. Pancreatic cancer behaves as a systemic disease requiring effective systemic therapy after resection., Trial Registration: ClinicalTrials.gov identifier: NCT00058201, EudraCT 2007-004299-38, and ISRCTN 96397434.
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- 2019
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35. Bordetella bronchiseptica Pneumonia in an Extremely-Low-Birth-Weight Neonate.
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Ting YJ, Ho PL, and Wong KY
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Bordetella bronchiseptica, a gram-negative coccobacillus, is a common veterinary pathogen. In both domestic and wild animals, this bacterium causes respiratory infections including infectious tracheobronchitis in dogs and atrophic rhinitis in swine. Human infections are rare and have been documented in immunocompromised hosts. Here, we describe an extremely-low-birth-weight infant with B. bronchiseptica pneumonia. This is the first report that describes the microorganism's responsibility in causing nosocomial infection in a preterm neonate. He recovered uneventfully after a course of meropenem. It is possible that the bacteria colonize the respiratory tracts of our health care workers or parents who may have had contact with pets and then transmitted the bacterium to our patient. Follow-up until 21 months of age showed normal growth and development. He did not suffer from any significant residual respiratory disease.
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- 2011
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36. Gastric pneumatosis in a premature neonate.
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Ting YJ, Chan KL, Wong SC, Chim S, and Wong KY
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Gastric pneumatosis is extremely rare during infancy. It has been reported in association with necrotizing enterocolitis or congenital abnormalities such as pyloric stenosis. Here, we report a case of gastric pneumatosis in a premature neonate on synchronized nasal intermittent positive pressure ventilation. No pneumatosis was noted in the rest of the bowel or esophagus. There could have been mild damage in the gastric mucosa, either related to the placement of the feeding tube or secondary to the use of indomethacin or both. The condition was further aggravated by noninvasive ventilation. An increase in intragastric pressure resulted in the submucosal dissection of air followed by the development of gastric pneumatosis. Conservative management strategies, including the use of a nasogastric tube for decompression and the withholding of feeding, successfully managed the gastric pneumatosis in our patient. An uneventful recovery was made after conservative management. Prompt recognition and evaluation of this condition were essential for making the diagnosis.
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- 2011
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37. L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression.
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Du F, Qian ZM, Zhu L, Wu XM, Yung WH, Tsim TY, and Ke Y
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- Animals, Astrocytes, Cation Transport Proteins genetics, Cells, Cultured, Cerebral Cortex cytology, Culture Media, Conditioned, Dose-Response Relationship, Drug, Neurons pathology, Rats, Rats, Wistar, Cation Transport Proteins physiology, Iron metabolism, Levodopa toxicity, Neurotoxicity Syndromes etiology, Response Elements
- Abstract
Background: The mechanisms underlying neurotoxicity caused by L-DOPA are not yet completely known. Based on recent findings, we speculated that the increased expression of divalent metal transporter 1 without iron-response element (DMT1-IRE) induced by L-DOPA might play a critical role in the development of L-DOPA neurotoxicity. To test this hypothesis, we investigated the effects of astrocyte-conditioned medium (ACM) and siRNA DMT-IRE on L-DOPA neurotoxicity in cortical neurons., Methods and Findings: We demonstrated that neurons treated with L-DOPA have a significant dose-dependent decrease in neuronal viability (MTT Assay) and increase in iron content (using a graphite furnace atomic absorption spectrophotometer), DMT1-IRE expression (Western blot analysis) and ferrous iron (55Fe(II)) uptake. Neurons incubated in ACM with or without L-DOPA had no significant differences in their morphology, Hoechst-33342 staining or viability. Also, ACM significantly inhibited the effects of L-DOPA on neuronal iron content as well as DMT1-IRE expression. In addition, we demonstrated that infection of neurons with siRNA DMT-IRE led to a significant decrease in DMT1-IRE expression as well as L-DOPA neurotoxicity., Conclusion: The up-regulation of DMT1-IRE and the increase in DMT1-IRE-mediated iron influx play a key role in L-DOPA neurotoxicity in cortical neurons.
- Published
- 2009
- Full Text
- View/download PDF
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